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708 results on '"Rifflet A"'

103. Peptidoglycan analysis reveals that synergistic deacetylase activity in vegetative

Author

Héloise, Coullon, Aline, Rifflet, Richard, Wheeler, Claire, Janoir, Ivo G, Boneca, and Thomas, Candela

Subjects
bacterial pathogenesis, Hydrolases, Acylation, Glycobiology and Extracellular Matrices, Kaplan-Meier Estimate, Microbial Sensitivity Tests, Peptidoglycan, Microbiology, Bacterial Proteins, Cell Wall, Cricetinae, Animals, bacteria, lysozyme, N-deacetylase, Glucosamine, Virulence, Clostridioides difficile, bacterial metabolism, Clostridium difficile, Immunity, Innate, Mutagenesis, Host-Pathogen Interactions, Clostridium Infections, Female, Muramidase
Abstract

Clostridium difficile is an anaerobic and spore-forming bacterium responsible for 15–25% of postantibiotic diarrhea and 95% of pseudomembranous colitis. Peptidoglycan is a crucial element of the bacterial cell wall that is exposed to the host, making it an important target for the innate immune system. The C. difficile peptidoglycan is largely N-deacetylated on its glucosamine (93% of muropeptides) through the activity of enzymes known as N-deacetylases, and this N-deacetylation modulates host–pathogen interactions, such as resistance to the bacteriolytic activity of lysozyme, virulence, and host innate immune responses. C. difficile genome analysis showed that 12 genes potentially encode N-deacetylases; however, which of these N-deacetylases are involved in peptidoglycan N-deacetylation remains unknown. Here, we report the enzymes responsible for peptidoglycan N-deacetylation and their respective regulation. Through peptidoglycan analysis of several mutants, we found that the N-deacetylases PdaV and PgdA act in synergy. Together they are responsible for the high level of peptidoglycan N-deacetylation in C. difficile and the consequent resistance to lysozyme. We also characterized a third enzyme, PgdB, as a glucosamine N-deacetylase. However, its impact on N-deacetylation and lysozyme resistance is limited, and its physiological role remains to be dissected. Finally, given the influence of peptidoglycan N-deacetylation on host defense against pathogens, we investigated the virulence and colonization ability of the mutants. Unlike what has been shown in other pathogenic bacteria, a lack of N-deacetylation in C. difficile is not linked to a decrease in virulence.

Published
2019

104. A peptide of a type I toxin-antitoxin system induces Helicobacter pylori morphological transformation from spiral-shape to coccoids

Author

Hilde De Reuse, Lamya El Mortaji, Aline Rifflet, Stéphanie Marsin, J. Pablo Radicella, Ivo G. Boneca, Gérard Pehau-Arnaudet, and Alejandro Tejada-Arranz

Subjects
biology, Toxin, Effector, Helicobacter pylori, biology.organism_classification, medicine.disease_cause, Microbiology, chemistry.chemical_compound, Plasmid, chemistry, medicine, Peptidoglycan, Antitoxin, Pathogen, Bacteria
Abstract

SummaryToxin-antitoxin systems are found in many bacterial chromosomes and plasmids with roles ranging from plasmid stabilization to biofilm formation and persistence. In these systems, the expression/activity of the toxin is counteracted by an antitoxin, which in type I systems is an antisense-RNA. While the regulatory mechanisms of these systems are mostly well-defined, the toxins’ biological activity and expression conditions are less understood. Here, these questions were investigated for a type I toxin-antitoxin system (AapA1-IsoA1) expressed from the chromosome of the human pathogen Helicobacter pylori. We show that expression of the AapA1 toxin in H. pylori causes growth arrest associated with rapid morphological transformation from spiral-shaped bacteria to round coccoid cells. Coccoids are observed in patients and during in vitro growth as a response to different stress conditions. The AapA1 toxin, first molecular effector of coccoids to be identified, targets H. pylori inner membrane without disrupting it, as visualized by Cryo-EM. The peptidoglycan composition of coccoids is modified with respect to spiral bacteria. No major changes in membrane potential or ATP concentration result from AapA1 expression, suggesting coccoid viability. Single-cell live microscopy tracking the shape conversion suggests a possible association of this process with cell elongation/division interference. Oxidative stress induces coccoid formation and is associated with repression of the antitoxin promoter and enhanced processing of its transcript, leading to an imbalance in favor of AapA1 toxin expression.Our data support the hypothesis of viable coccoids with characteristics of dormant bacteria that might be important in H. pylori infections refractory to treatment.Significance StatementHelicobacter pylori, a gastric pathogen causing 800,000 deaths in the world annually, is encountered both in vitro and in patients as spiral-shaped bacteria and as round cells named coccoids. We discovered that the toxin from a chromosomal type I toxin-antitoxin system is targeting H. pylori membrane and acting as an effector of H. pylori morphological conversion to coccoids. We showed that these round cells maintain their membrane integrity and metabolism, strongly suggesting that they are viable dormant bacteria. Oxidative stress was identified as a signal inducing toxin expression and coccoid formation. Our findings reveal new insights into a form of dormancy of this bacterium that might be associated with H. pylori infections refractory to treatment.

Published
2019
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105. The 16 T Dipole Development Program for FCC and HE-LHC

Author

S.A. Gourlay, Massimo Sorbi, Davide Tommasini, Alexander V. Zlobin, Marc Dhalle, Toru Ogitsu, Carmine Senatore, Shlomo Caspi, Helene Felice, F. Toral, Emanuela Barzi, Peng Gao, Frederic Savary, Ignacio Aviles Santillana, Antti Stenvall, L. Tavian, Mariusz Juchno, Soren Prestemon, Pasquale Fabbricatore, Maria Durante, Giovanni Bellomo, Marco Prioli, Bernhard Auchmann, G.V. Velev, Stefania Farinon, R. Valente, C. Pes, Frank Zimmermann, Etienne Rochepault, Christian Scheuerlein, Eric Coatanéa, Susana Izquierdo Bermudez, Sotiris Kokkinos, S. Russenschuck, Luca Bottura, Kari Koskinen, Clement Lorin, Alexandre Louzguiti, Tiina Salmi, Konstantinos Loukas, M. Statera, Pierluigi Bruzzone, Felix Wolf, Maxim Marchevsky, Bernardo Bordini, Samuele Mariotto, Diego Arbelaez, T. Tervoort, Marta Bajko, Barbara Gold, Alessandra Pampaloni, Arjan Verweij, Inigo Sancho Fernandez, Jac Perez, Carlo Petrone, Thodoris Gortsas, Alejandro Fernandez, Alessandro Maria Ricci, Friedrich Lackner, Kari Lyytikainen, Ananda Chakraborti, Michael Benedikt, Demosthenes Polyzos, Lucas Brouwer, Daniel Schoerling, Amalia Ballarino, Igor Novitski, Michel Segreti, Javier Munilla, Vadim Kashikhin, Giuseppe Montenero, J. M. Rifflet, S. Wessel, Gijs de Rijk, Charilaos Kokkinos, Barbara Caiffi, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Energy, Materials and Systems

Subjects
magnet: design, 16 T, 7. Clean energy, 01 natural sciences, chemistry.chemical_compound, storage rings, Superconducting, HE-LHC, Superconducting magnets, Nb3Sn, FCC, center-of-mass energy, Physics, Large Hadron Collider, future circular collider, Nb, 3, Sn, superconducting, common-coil magnet, Condensed Matter Physics, bending magnet, Electronic, Optical and Magnetic Materials, Conductor, Europe, Upgrade, CERN LHC Coll, Nb Sn, niobium: tin, performance, electron volt energy 27.0 TeV, General Physics, size 100.0 km, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Superconducting magnet, ddc:500.2, Nb $_{3}$ Sn, canted-cos-theta magnet, Future Circular Collider, electron volt energy 100.0 TeV, 16 T dipole development program, Apertures, 0103 physical sciences, nb3sn, Aerospace engineering, Niobium-tin, Electrical and Electronic Engineering, 010306 general physics, Electrical conductor, energy upgrade, activity report, bending magnets, conductor stress levels, business.industry, model magnets, Materials Engineering, magnet: superconductivity, 22/4 OA procedure, Magnetoacoustic effects, chemistry, Conductors, block-type magnet, Magnet, Physics::Accelerator Physics, business, accelerator magnets
Abstract

International audience; A future circular collider (FCC) with a center-of-mass energy of 100 TeV and a circumference of around 100 km, or an energy upgrade of the LHC (HE-LHC) to 27 TeV require bending magnets providing 16 T in a 50-mm aperture. Several development programs for these magnets, based on Nb$_3$Sn technology, are being pursued in Europe and in the U.S. In these programs, cos-theta, block-type, common-coil, and canted-cos-theta magnets are explored; first model magnets are under manufacture; limits on conductor stress levels are studied; and a conductor with enhanced characteristics is developed. This paper summarizes and discusses the status, plans, and preliminary results of these programs.

Published
2019
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106. FCC Physics Opportunities

Author

Abada, A., Abbrescia, M., AbdusSalam, S. S., Abdyukhanov, I., Fernandez, J. Abelleira, Abramov, A., Aburaia, M., Acar, A. O., Adzic, P. R., Agrawal, P., Aguilar-Saavedra, J. A., Aguilera-Verdugo, J. J., Aiba, M., Aichinger, I., Aielli, G., Akay, A., Akhundov, A., Aksakal, H., Albacete, J. L., Albergo, S., Alekou, A., Aleksa, M., Aleksan, R., Fernandez, R. M. Alemany, Alexahin, Y., Alía, R. G., Alioli, S., Tehrani, N. Alipour, Allanach, B. C., Allport, P. P., Altınlı, M., Altmannshofer, W., Ambrosio, G., Amorim, D., Amstutz, O., Anderlini, L., Andreazza, A., Andreini, M., Andriatis, A., Andris, C., Andronic, A., Angelucci, M., Antinori, F., Antipov, S. A., Antonelli, M., Antonello, M., Antonioli, P., Antusch, S., Anulli, F., Apolinário, L., Apollinari, G., Apollonio, A., Appelö, D., Appleby, R. B., Apyan, Ara., Apyan, Arm., Arbey, A., Arbuzov, A., Arduini, G., Arı, V., Arias, S., Armesto, N., Arnaldi, R., Arsenyev, S. A., Arzeo, M., Asai, S., Aslanides, E., Aßmann, R. W., Astapovych, D., Atanasov, M., Atieh, S., Attié, D., Auchmann, B., Audurier, A., Aull, S., Aumon, S., Aune, S., Avino, F., Avrillaud, G., Aydın, G., Azatov, A., Azuelos, G., Azzi, P., Azzolini, O., Azzurri, P., Bacchetta, N., Bacchiocchi, E., Bachacou, H., Baek, Y. W., Baglin, V., Bai, Y., Baird, S., Baker, M. J., Baldwin, M. J., Ball, A. H., Ballarino, A., Banerjee, S., Barber, D. P., Barducci, D., Barjhoux, P., Barna, D., Barnaföldi, G. G., Barnes, M. J., Barr, A., García, J. Barranco, da Costa, J. Barreiro Guimarães, Bartmann, W., Baryshevsky, V., Barzi, E., Bass, S. A., Bastianin, A., Baudouy, B., Bauer, F., Bauer, M., Baumgartner, T., Bautista-Guzmán, I., Bayındır, C., Beaudette, F., Bedeschi, F., Béguin, M., Bellafont, I., Bellagamba, L., Bellegarde, N., Belli, E., Bellingeri, E., Bellini, F., Bellomo, G., Belomestnykh, S., Bencivenni, G., Benedikt, M., Bernardi, G., Bernardi, J., Bernet, C., Bernhardt, J. M., Bernini, C., Berriaud, C., Bertarelli, A., Bertolucci, S., Besana, M. I., Besançon, M., Beznosov, O., Bhat, P., Bhat, C., Biagini, M. E., Biarrotte, J.-L., Chevalier, A. Bibet, Bielert, E. R., Biglietti, M., Bilei, G. M., Bilki, B., Biscari, C., Bishara, F., Blanco-García, O. R., Blánquez, F. R., Blekman, F., Blondel, A., Blümlein, J., Boccali, T., Boels, R., Bogacz, S. A., Bogomyagkov, A., Boine-Frankenheim, O., Boland, M. J., Bologna, S., Bolukbasi, O., Bomben, M., Bondarenko, S., Bonvini, M., Boos, E., Bordini, B., Bordry, F., Borghello, G., Borgonovi, L., Borowka, S., Bortoletto, D., Boscherini, D., Boscolo, M., Boselli, S., Bosley, R. R., Bossu, F., Botta, C., Bottura, L., Boughezal, R., Boutin, D., Bovone, G., Jelisavc̆ić, I. Božović, Bozbey, A., Bozzi, C., Bozzini, D., Braccini, V., Braibant-Giacomelli, S., Bramante, J., Braun-Munzinger, P., Briffa, J. A., Britzger, D., Brodsky, S. J., Brooke, J. J., Bruce, R., De Renstrom, P. Brückman, Bruna, E., Brüning, O., Brunner, O., Brunner, K., Bruzzone, P., Buffat, X., Bulyak, E., Burkart, F., Burkhardt, H., Burnet, J.-P., Butin, F., Buttazzo, D., Butterworth, A., Caccia, M., Cai, Y., Caiffi, B., Cairo, V., Cakir, O., Calaga, R., Calatroni, S., Calderini, G., Calderola, G., Caliskan, A., Calvet, D., Calviani, M., Camalich, J. M., Camarri, P., Campanelli, M., Camporesi, T., Canbay, A. C., Canepa, A., Cantergiani, E., Cantore-Cavalli, D., Capeans, M., Cardarelli, R., Cardella, U., Cardini, A., Calame, C. M. Carloni, Carra, F., Carra, S., Carvalho, A., Casalbuoni, S., Casas, J., Cascella, M., Castelnovo, P., Castorina, G., Catalano, G., Cavasinni, V., Cazzato, E., Cennini, E., Cerri, A., Cerutti, F., Cervantes, J., Chaikovska, I., Chakrabortty, J., Chala, M., Chamizo-Llatas, M., Chanal, H., Chanal, D., Chance, S., Chancé, A., Charitos, P., Charles, J., Charles, T. K., Chattopadhyay, S., Chehab, R., Chekanov, S. V., Chen, N., Chernoded, A., Chetvertkova, V., Chevalier, L., Chiarelli, G., Chiarello, G., Chiesa, M., Chiggiato, P., Childers, J. T., Chmielińska, A., Cholakian, A., Chomaz, P., Chorowski, M., Chou, W., Chrzaszcz, M., Chyhyrynets, E., Cibinetto, G., Ciftci, A. K., Ciftci, R., Cimino, R., Ciuchini, M., Clark, P. J., Coadou, Y., Cobal, M., Coccaro, A., Cogan, J., Cogneras, E., Collamati, F., Colldelram, C., Collier, P., Collot, J., Contino, R., Conventi, F., Cook, C. T. A., Cooley, L., Corcella, G., Cornell, A. S., Corral, G. H., Correia-Rodrigues, H., Costanza, F., Pinto, P. Costa, Couderc, F., Coupard, J., Craig, N., Garrido, I. Crespo, Crivellin, A., Croteau, J. F., Crouch, M., Alaniz, E. Cruz, Curé, B., Curti, J., Curtin, D., Czech, M., Dachauer, C., D’Agnolo, R. T., Daibo, M., Dainese, A., Dalena, B., Daljevec, A., Dallapiazza, W., Schwartzentruber, L. D’Aloia, Dam, M., D’Ambrosio, G., Das, S. P., DasBakshi, S., da Silva, W., da Silveira, G. G., D’Auria, V., D’Auria, S., David, A., Davidek, T., Deandrea, A., de Blas, J., Debono, C. J., De Curtis, S., De Filippis, N., de Florian, D., Deghaye, S., de Jong, S. J., Bo, C. Del, Duca, V. Del, Delikaris, D., Deliot, F., Dell’Acqua, A., Rose, L. Delle, Delmastro, M., De Lucia, E., Demarteau, M., Denegri, D., Deniau, L., Denisov, D., Denizli, H., Denner, A., d’Enterria, D., de Rijk, G., De Roeck, A., Derue, F., Deschamps, O., Descotes-Genon, S., Dev, P. S. B., de Vivie de Régie, J. B., Dewanjee, R. K., Ciaccio, A. Di, Cicco, A. Di, Dillon, B. M., Micco, B. Di, Nezza, P. Di, Vita, S. Di, Doblhammer, A., Dominjon, A., D’Onofrio, M., Dordei, F., Drago, A., Draper, P., Drasal, Z., Drewes, M., Duarte, L., Dubovyk, I., Duda, P., Dudarev, A., Dudko, L., Duellmann, D., Dünser, M., Pree, T. du, Durante, M., Yildiz, H. Duran, Dutta, S., Duval, F., Duval, J. M., Dydyshka, Ya., Dziewit, B., Eisenhardt, S., Eisterer, M., Ekelof, T., Khechen, D. El, Ellis, S. A., Ellis, J., Ellison, J. A., Elsener, K., Elsing, M., Enari, Y., Englert, C., Eriksson, H., Eskola, K. J., Esposito, L. S., Etisken, O., Etzion, E., Fabbricatore, P., Falkowski, A., Falou, A., Faltova, J., Fan, J., Fanò, L., Farilla, A., Farinelli, R., Farinon, S., Faroughy, D. A., Fartoukh, S. D., Faus-Golfe, A., Fawcett, W. J., Felici, G., Felsberger, L., Ferdeghini, C., Navarro, A. M. Fernandez, Fernández-Téllez, A., Troitino, J. Ferradas, Ferrara, G., Ferrari, R., Ferreira, L., da Silva, P. Ferreira, Ferrera, G., Ferro, F., Fiascaris, M., Fiorendi, S., Fiorio, C., Fischer, O., Fischer, E., Flieger, W., Florio, M., Fonnesu, D., Fontanesi, E., Foppiani, N., Foraz, K., Forkel-Wirth, D., Forte, S., Fouaidy, M., Fournier, D., Fowler, T., Fox, J., Francavilla, P., Franceschini, R., Franchino, S., Franco, E., Freitas, A., Fuks, B., Furukawa, K., Furuseth, S. V., Gabrielli, E., Gaddi, A., Galanti, M., Gallo, E., Ganjour, S., Gao, Jia., Gao, Jie., Diaz, V. Garcia, Pérez, M. García, Tabarés, L. García, Garion, C., Garzelli, M. V., Garzia, I., Gascon-Shotkin, S. M., Gaudio, G., Gay, P., Ge, S.-F., Gehrmann, T., Genest, M. H., Gerard, R., Gerigk, F., Gerwig, H., Giacomelli, P., Giagu, S., Gianfelice-Wendt, E., Gianotti, F., Giffoni, F., Gilardoni, S. S., Costa, M. Gil, Giovannetti, M., Giovannozzi, M., Giubellino, P., Giudice, G. F., Giunta, A., Gladilin, L. K., Glukhov, S., Gluza, J., Gobbi, G., Goddard, B., Goertz, F., Golling, T., Gonçalves, D., Goncalves, V. P., Gonçalo, R., Gomez, L. A. Gonzalez, Zadeh, S. Gorgi, Gorine, G., Gorini, E., Gourlay, S. A., Gouskos, L., Grancagnolo, F., Grassellino, A., Grau, A., Graverini, E., Gray, H. M., Greco, Ma., Greco, Mi., Grenard, J.-L., Grimm, O., Grojean, C., Gromov, V. A., Grosse-Oetringhaus, J. F., Grudiev, A., Grzanka, K., Gu, J., Guadagnoli, D., Guidi, V., Guiducci, S., Canton, G. Guillermo, Günaydin, Y. O., Gupta, R., Gupta, R. S., Gutierrez, J., Gutleber, J., Guyot, C., Guzey, V., Gwenlan, C., Haberstroh, Ch., Hacışahinoğlu, B., Haerer, B., Hahn, K., Hahn, T., Hammad, A., Han, C., Hance, M., Hannah, A., Harris, P. C., Hati, C., Haug, S., Hauptman, J., Haurylavets, V., He, H-J., Hegglin, A., Hegner, B., Heinemann, K., Heinemeyer, S., Helsens, C., Henriques, Ana., Henriques, And., Hernandez, P., Hernández-Pinto, R. J., Hernandez-Sanchez, J., Herzig, T., Hiekkanen, I., Hillert, W., Hoehn, T., Hofer, M., Höfle, W., Holdener, F., Holleis, S., Holzer, B., Hong, D. K., Honorato, C. G., Hopkins, S. C., Hrdinka, J., Hug, F., Humann, B., Humer, H., Hurth, T., Hutton, A., Iacobucci, G., Ibarrola, N., Iconomidou-Fayard, L., Ilyina-Brunner, K., Incandela, J., Infantino, A., Ippolito, V., Ishino, M., Islam, R., Ita, H., Ivanovs, A., Iwamoto, S., Iyer, A., Bermudez, S. Izquierdo, Jadach, S., Jamin, D. O., Janot, P., Jarry, P., Jeff, A., Jenny, P., Jensen, E., Jensen, M., Jiang, X., Jiménez, J. M., Jones, M. A., Jones, O. R., Jowett, J. M., Jung, S., Kaabi, W., Kado, M., Kahle, K., Kalinovskaya, L., Kalinowski, J., Kamenik, J. F., Kannike, K., Kara, S. O., Karadeniz, H., Karaventzas, V., Karpov, I., Kartal, S., Karyukhin, A., Kashikhin, V., Behr, J. Katharina, Kaya, U., Keintzel, J., Keinz, P. A., Keppel, K., Kersevan, R., Kershaw, K., Khanpour, H., Khatibi, S., Yanehsari, M. Khatiri, Khoze, V. V., Kieseler, J., Kilic, A., Kilpinen, A., Kim, Y.-K., Kim, D. W., Klein, U., Klein, M., Kling, F., Klinkenberg, N., Klöppel, S., Klute, M., Klyukhin, V. I., Knecht, M., Kniehl, B., Kocak, F., Koeberl, C., Kolano, A. M., Kollegger, A., Kołodziej, K., Kolomiets, A. A., Komppula, J., Koop, I., Koppenburg, P., Koratzinos, M., Kordiaczyńska, M., Korjik, M., Kortner, O., Kostka, P., Kotlarski, W., Kotnig, C., Köttig, T., Kotwal, A. V., Kovalenko, A. D., Kowalski, S., Kozaczuk, J., Kozlov, G. A., Kozub, S. S., Krainer, A. M., Kramer, T., Krämer, M., Krammer, M., Krasnov, A. A., Krauss, F., Kravalis, K., Kretzschmar, L., Kriske, R. M., Kritscher, H., Krkotic, P., Kroha, H., Kucharczyk, M., Kuday, S., Kuendig, A., Kuhlmann, G., Kulesza, A., Kumar, Mi., Kumar, Mu., Kusina, A., Kuttimalai, S., Kuze, M., Kwon, T., Lackner, F., Lackner, M., La Francesca, E., Laine, M., Lamanna, G., La Mendola, S., Lançon, E., Landsberg, G., Langacker, P., Lange, C., Langner, A., Lankford, A. J., Lansberg, J. P., Lari, T., Laycock, P. J., Lebrun, P., Lechner, A., Lee, K., Lee, S., Lee, R., Lefevre, T., Guen, P. Le, Lehtinen, T., Leith, S. B., Lenzi, P., Leogrande, E., Leonidopoulos, C., Leon-Monzon, I., Lerner, G., Leroy, O., Lesiak, T., Lévai, P., Leveratto, A., Levichev, E., Li, G., Li, S., Li, R., Liberati, D., Liepe, M., Lissauer, D. A., Liu, Z., Lobko, A., Locci, E., Agaliotis, E. Logothetis, Lombardo, M. P., Long, A. J., Lorin, C., Losito, R., Louzguiti, A., Low, I., Lucchesi, D., Lucchini, M. T., Luciani, A., Lueckhof, M., Lunt, A. J. G., Luzum, M., Lyubimtsev, D. A., Maggiora, M., Magnin, N., Mahmoud, M. A., Mahmoudi, F., Maitre, J., Makarenko, V., Malagoli, A., Malclés, J., Malgeri, L., Mallon, P. J., Maltoni, F., Malvezzi, S., Malyshev, O. B., Mancinelli, G., Mandrik, P., Manfrinetti, P., Mangano, M., Manil, P., Mannelli, M., Marchiori, G., Marhauser, F., Mariani, V., Marinozzi, V., Mariotto, S., Marquard, P., Marquet, C., Marriott-Dodington, T., Martin, R., Martin, O., Camalich, J. Martin, Martinez, T., Bruzual, H. Martinez, Martínez-Hernández, M. I., Martins, D. E., Marzani, S., Marzocca, D., Marzola, L., Masciocchi, S., Masina, I., Massimiliano, A., Massironi, A., Masubuchi, T., Matveev, V. A., Mazzoni, M. A., McCullough, M., McIntosh, P. A., Meade, P., Medina, L., Meier, A., Meignan, J., Mele, B., Saraiva, J. G. Mendes, Menez, F., Mentink, M., Meoni, E., Meridiani, P., Merk, M., Mermod, P., Mertens, V., Mether, L., Métral, E., Migliorati, M., Milanese, A., Milardi, C., Milhano, G., Militsyn, B. L., Millet, F., Minashvili, I., Minervini, J. V., Miralles, L. S., Mirarchi, D., Mishima, S., Missiaen, D. P., Mitselmakher, G., Mitsuhashi, T., Mnich, J., Najafabadi, M. Mohammadi, Mohapatra, R. N., Mokhov, N., Molson, J. G., Monge, R., Montag, C., Montagna, G., Monteil, S., Montenero, G., Montesinos, E., Moortgat, F., Morange, N., Morello, G., Llácer, M. Moreno, Moretti, M., Moretti, S., Morley, A. K., Moros, A., Morozov, I., Morretta, V., Morrone, M., Mostacci, A., Muanza, S., Muchnoi, N., Mühlegger, M., Mulder, M., Mulders, M., Müller, B., Müller, F., Müller, A.-S., Munilla, J., Murray, M. J., Muttoni, Y., Myers, S., Mylona, M., Nachtman, J., Nakamoto, T., Nardecchia, M., Nardini, G., Nason, P., Nergiz, Z., Nesterenko, A. V., Nettsträter, A., Neubüser, C., Neundorf, J., Niccoli, F., Nicrosini, O., Nie, Y., Niedermayer, U., Niedziela, J., Niemi, A., Nikitin, S. A., Nisati, A., No, J. M., Nonis, M., Nosochkov, Y., Novák, M., Novokhatski, A., O’Callaghan, J. M., Ochando, C., Ogur, S., Ohmi, K., Oide, K., Okorokov, V. A., Okumura, Y., Oleari, C., Olness, F. I., Onel, Y., Ortino, M., Osborne, J., Osland, P., Otto, T., Oyulmaz, K. Y., Ozansoy, A., Özcan, V., Özdemir, K., Pagliarone, C. E., da Silva, H. F. Pais, Palmieri, E., Palumbo, L., Pampaloni, A., Pan, R.-Q., Panareo, M., Panella, O., Panico, G., Panizzo, G., Pankov, A. A., Pantsyrny, V., Papadopoulos, C. G., Papaefstathiou, A., Papaphilippou, Y., Parker, M. A., Parma, V., Pasquali, M., Patra, S. K., Patterson, R., Paukkunen, H., Pauss, F., Peggs, S., Penttinen, J.-P., Peón, G., Perepelkin, E. E., Perez, E., Perez, J. C., Perez, G., Pérez, F., Codina, E. Perez, Morales, J. Perez, Perfilov, M., Pernegger, H., Peruzzi, M., Pes, C., Peters, K., Petracca, S., Petriello, F., Pezzotti, L., Pfeiffer, S., Piccinini, F., Pieloni, T., Pierini, M., Pikhartova, H., Pikurs, G., Pilicer, E., Piminov, P., Pira, C., Pittau, R., Płaczek, W., Plagge, M., Plehn, T., Pleier, M.-A., Płoskoń, M., Podeur, M., Podlech, H., Podzorny, T., Poggioli, L., Poiron, A., Polesello, G., Lener, M. Poli, Polini, A., Polinski, J., Polozov, S. M., Ponce, L., Pont, M., Pontecorvo, L., Portaluri, T., Potamianos, K., Prasse, C., Prausa, M., Preinerstorfer, A., Premat, E., Price, T., Primavera, M., Prino, F., Prioli, M., Proudfoot, J., Provino, A., Pugnat, T., Pukhaeva, N., Puławski, S., Pulikowski, D., Punzi, G., Putti, M., Pyarelal, A., Quack, H., Quispe, M., Racioppi, A., Rafique, H., Raginel, V., Raidal, M., Ramírez-Uribe, N. S., Ramsey-Musolf, M. J., Rata, R., Ratoff, P., Ravotti, F., Teles, P. Rebello, Reboud, M., Redaelli, S., Renner, E., Rentería-Olivo, A. E., Rescigno, M., Reuter, J., Ribon, A., Ricci, A. M., Riegler, W., Riemann, S., Riemann, B., Riemann, T., Rifflet, J. M., Rimmer, R. A., Rinaldesi, R., Rinolfi, L., Rubiras, O. Rios, Risselada, T., Rivetti, A., Rivkin, L., Rizzo, T., Robens, T., Robert, F., Robson, A. J., Rochepault, E., Roda, C., Rodrigo, G., Rodríguez-Cahuantzi, M., Rogan, C., Roig, M., Rojas-Torres, S., Rojo, J., Rolandi, G., Rolando, G., Roloff, P., Romanenko, A., Romanov, A., Roncarolo, F., Sanchez, A. Rosado, Rosaz, G., Rossi, L., Rossi, A., Rossmanith, R., Rousset, B., Royon, C., Ruan, X., Ruehl, I., Ruhlmann-Kleider, V., Ruiz, R., Rumyantsev, L., Ruprecht, R., Ryazanov, A. I., Saba, A., Sadykov, R., de Jauregui, D. Saez, Sahin, M., Sailer, B., Saito, M., Sala, F., Salam, G. P., Salfeld-Nebgen, J., Salgado, C. A., Salini, S., Sallese, J. M., Salmi, T., Salzburger, A., Sampayo, O. A., Sanfilippo, S., Santiago, J., Santopinto, E., Santoro, R., Ull, A. Sanz, Sarasola, X., Sarpün, I. H., Sauvain, M., Savelyeva, S., Sawada, R., Sborlini, G. F. R., Schaffer, A., Schaumann, M., Schenk, M., Scheuerlein, C., Schienbein, I., Schlenga, K., Schmickler, H., Schmidt, R., Schoerling, D., Schoning, A., Schörner-Sadenius, T., Schott, M., Schulte, D., Schwaller, P., Schwanenberger, C., Schwemling, P., Schwerg, N., Scibile, L., Sciuto, A., Scomparin, E., Sebastiani, C., Seeber, B., Segreti, M., Selva, P., Selvaggi, M., Senatore, C., Senol, A., Serin, L., Serluca, M., Serra, N., Seryi, A., Sestini, L., Sfyrla, A., Shaposhnikov, M., Shaposhnikova, E., Sharkov, B. Yu., Shatilov, D., Shelton, J., Shiltsev, V., Shipsey, I. P., Shirkov, G. D., Shivaji, A., Shwartz, D., Sian, T., Sidorov, S., Siemko, A., Silvestrini, L., Simand, N., Simon, F., Singh, B. K., Siódmok, A., Sirois, Y., Sirtori, E., Sirvinskaite, R., Sitar, B., Sjöstrand, T., Skands, P., Skordis, E., Skovpen, K., Skrzypek, M., Slade, E., Slavich, P., Slovak, R., Smaluk, V., Smirnov, V., Snoeys, W., Soffi, L., Sollander, P., Solovyanov, O., Soltveit, H. K., Song, H., Sopicki, P., Sorbi, M., Spallino, L., Spannowsky, M., Spataro, B., Sphicas, P., Spiesberger, H., Spiller, P., Spira, M., Srivastava, T., Stachel, J., Stakia, A., Stanyard, J. L., Starchenko, E., Starikov, A. Yu., Staśto, A. M., Statera, M., Steerenberg, R., Steggemann, J., Stenvall, A., Stivanello, F., Stöckinger, D., Stoel, L. S., Stöger-Pollach, M., Strauss, B., Stuart, M., Stupakov, G., Su, S., Sublet, A., Sugita, K., Sulak, L., Sullivan, M. K., Sultansoy, S., Sumida, T., Suzuki, K., Sylva, G., Syphers, M. J., Sznajder, A., Taborelli, M., Tahir, N. A., Hod, E. Tal, Takeuchi, M., Tambasco, C., Tanaka, J., Tang, K., Tapan, I., Taroni, S., Tartarelli, G. F., Tassielli, G., Tavian, L., Taylor, T. M., Taylor, G. N., Teixeira, A. M., Tejeda-Muñoz, G., Telnov, V. I., Tenchini, R., Kate, H. H. J. ten, Terashi, K., Tesi, A., Testa, M., Tetrel, C., Teytelman, D., Thaler, J., Thamm, A., Thomas, S., Tiirakari, M. T., Tikhomirov, V., Tikhonov, D., Timko, H., Tisserand, V., Tkachenko, L. M., Tkaczuk, J., Tock, J. Ph., Todd, B., Todesco, E., Garcia, R. Tomás, Tommasini, D., Tonelli, G., Toral, F., Torims, T., Torre, R., Townsend, Z., Trant, R., Treille, D., Trentadue, L., Tricoli, A., Tricomi, A., Trischuk, W., Tropin, I. S., Tuchming, B., Tudora, A. A., Turbiarz, B., Cakir, I. Turk, Turri, M., Tydecks, T., Usovitsch, J., Uythoven, J., Vaglio, R., Valassi, A., Valchkova, F., Garcia, M. A. Valdivia, Valente, P., Valente, R. U., Valente-Feliciano, A.-M., Valentino, G., Silva, L. Vale, Valet, J. M., Valizadeh, R., Valle, J. W. F., Vallecorsa, S., Vallone, G., Leeuwen, M. van, Rienen, U. H. van, Riesen-Haupt, L. van, Varasteh, M., Vecchi, L., Vedrine, P., Velev, G., Veness, R., Ventura, A., Delsolaro, W. Venturini, Verducci, M., Verhaaren, C. B., Vernieri, C., Verweij, A. P., Verwilligen, O., Viazlo, O., Vicini, A., Viehhauser, G., Vignaroli, N., Vignolo, M., Vitrano, A., Vivarelli, I., Vlachos, S., Vogel, M., Vogt, D. M., Völkl, V., Volkov, P., Volpini, G., Ahnen, J. von, Vorotnikov, G., Voutsinas, G. G., Vysotsky, V., Wagner, U., Wallny, R., Wang, L.-T., Wang, R., Wang, K., Ward, B. F. L., Watson, T. P., Watson, N. K., Wa̧s, Z., Weiland, C., Weinzierl, S., Welsch, C. P., Wenninger, J., Widorski, M., Wiedemann, U. A., Wienands, H.-U., Wilkinson, G., Williams, P. H., Winter, A., Wohlfahrt, A., Wojtoń, T., Wollmann, D., Womersley, J., Woog, D., Wu, X., Wulzer, A., Yanehsari, M. K., Yang, G., Yang, H. J., Yao, W.-M., Yazgan, E., Yermolchik, V., Yilmaz, Ay., Yilmaz, Al., Yoo, H.-D., Yost, S. A., You, T., Young, C., Yu, T.-T., Yu, F., Zaborowska, A., Zadeh, S. G., Zahnd, M., Zanetti, M., Zanotto, L., Zawiejski, L., Zeiler, P., Zerlauth, M., Zernov, S. M., Porta, G. Zevi Dell, Zhang, Z., Zhang, Y., Zhang, C., Zhang, H., Zhao, Z., Zhong, Y.-M., Zhou, J., Zhou, D., Zhuang, P., Zick, G., Zimmermann, F., Zinn-Justin, J., Zivkovic, L., Zlobin, A. V., Zobov, M., Zupan, J., Zurita, J., Uşak Üniversitesi, Fen Edebiyat Fakültesi, Fizik Bölümü, and Şahin, Mehmet

Subjects
CERN, FCC, PHYSICS, HIGH ENERGY PHYSICS, High Energy Physics::Phenomenology, High Energy Physics::Experiment, ddc
Abstract

We review the physics opportunities of the Future Circular Collider, covering its e+e−, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.

Published
2019

107. Supplemental material for Quantification of low abundance Yersinia pestis markers in dried blood spots by immuno-capture and quantitative high-resolution targeted mass spectrometry

Author

Rifflet, Aline, Filali, Sofia, Chenau, Jérôme, Simon, Stéphanie, Fenaille, François, Junot, Christophe, Carniel, Elisabeth, and Becher, François

Subjects
FOS: Materials engineering, 91299 Materials Engineering not elsewhere classified
Abstract

Supplemental Material for Quantification of low abundance Yersinia pestis markers in dried blood spots by immuno-capture and quantitative high-resolution targeted mass spectrometry by Aline Rifflet, Sofia Filali, Jérôme Chenau, Stéphanie Simon, François Fenaille, Christophe Junot, Elisabeth Carniel and François Becher in European Journal of Mass Spectrometry

Published
2019
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108. The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation

Author

Aline Rifflet, Nathalie Rolhion, Pascale Cossart, Adam Redzej, Tiago R. D. Costa, Allison H. Williams, Gabriel Waksman, Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall (BGPB), Institut Pasteur [Paris] (IP), Birkbeck College [University of London], Interactions Bactéries-Cellules (UIBC), Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Imperial College London, This work was funded by Wellcome Trust grant 098302 to G.W. A.H.W. work was supported by Institut Carnot–Pasteur Maladies Infectieuses fellowship and the EMBO long-term fellowship (ALTF 732-2010). P.C. work is supported by the European Research Council (ERC), Advanced Grant BacCellEpi (670823), ANR Investissement d’Avenir Programme (10-LABX-62-IBEID), and the Fondation le Roch les Mousquetaires. P.C. is a Senior International Research Scholar of the Howard Hughes Medical Institute., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), European Project: 670823,H2020,ERC-2014-ADG,BacCellEpi(2015), Institut Pasteur [Paris], Institut National de la Recherche Agronomique (INRA)-Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Lallemant, Pascal, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, and Bacterial, cellular and epigenetic factors that control enteropathogenicity - BacCellEpi - - H20202015-10-01 - 2018-09-30 - 670823 - VALID

Subjects
[SDE] Environmental Sciences, 0301 basic medicine, web server, Cryo-electron microscopy, General Physics and Astronomy, 02 engineering and technology, Protein Structure, Secondary, molecular architecture, Fight-or-flight response, Protein structure, lcsh:Science, rsbr, bacillus-subtilis, Multidisciplinary, output, Chemistry, phosphorylation, 021001 nanoscience & nanotechnology, [SDE]Environmental Sciences, Pathogens, Signal transduction, 0210 nano-technology, Signal Transduction, signaling pathway, Phosphorylation sites, Science, Supramolecular chemistry, Glutamic Acid, Sigma Factor, Protein Serine-Threonine Kinases, system, bcs, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Protein Domains, Multienzyme Complexes, Stress, Physiological, MD Multidisciplinary, Mechanism (biology), Cryoelectron Microscopy, Gene Expression Regulation, Bacterial, General Chemistry, Phosphoproteins, Listeria monocytogenes, 030104 developmental biology, Biophysics, lcsh:Q, A kinase, protein
Abstract

How the stressosome, the epicenter of the stress response in bacteria, transmits stress signals from the environment has remained elusive. The stressosome consists of multiple copies of three proteins RsbR, RsbS and RsbT, a kinase that is important for its activation. Using cryo-electron microscopy, we determined the atomic organization of the Listeria monocytogenes stressosome at 3.38 Å resolution. RsbR and RsbS are organized in a 60-protomers truncated icosahedron. A key phosphorylation site on RsbR (T209) is partially hidden by an RsbR flexible loop, whose “open” or “closed” position could modulate stressosome activity. Interaction between three glutamic acids in the N-terminal domain of RsbR and the membrane-bound mini-protein Prli42 is essential for Listeria survival to stress. Together, our data provide the atomic model of the stressosome core and highlight a loop important for stressosome activation, paving the way towards elucidating the mechanism of signal transduction by the stressosome in bacteria., The bacterial stressosome is a large nanomachine and a key inducer of stress response. Here, the authors present the cryo-EM structure of the stressosome from the bacterial pathogen Listeria monocytogenes at 3.38 Å resolution and discuss its activation mechanism.

Published
2019
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109. Tests of the FRESCA2 100 mm bore Nb$_3$Sn block-coil magnet to a record field of 14.6 T

Author

Maria Durante, Nicolas Bourcey, Paolo Ferracin, Gijs de Rijk, Michal Duda, Etienne Rochepault, Daniel Turi, Douglas Martins Araujo, Pierre Manil, Juan Carlos Perez, J. Feuvrier, Hugo Bajas, Gerard Willering, Carlo Petrone, Marta Bajko, Jean-Michel Rifflet, Franco Mangiarotti, Luca Bottura, Lorenzo Bortot, Philippe Grosclaude, Havard Arnestad, Francoise Rondeaux, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
Materials science, cold powering tests, Aperture, size 100.0 mm, Nuclear engineering, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], FRESCA2 bore, Vibrations, Superconducting magnet, European project EuCARD, Stress, 01 natural sciences, Antenna measurements, magnetic flux density 14.6 T, magnet protection, magnetic flux density 13.3 T, Dipole magnet, 0103 physical sciences, CERN, FRESCA2, Nb3Sn, current 10.6 kA, Training, Electrical and Electronic Engineering, block coil dipole magnet, 010306 general physics, high field Nb3Sn magnet, Magnetic flux, magnet bore, Large Hadron Collider, superconducting coils, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Vibration, magnetic flux density 13 T, Electromagnetic coil, Magnet, CEA Saclay, niobium alloys, Magnetomechanical effects, hotspot temperature, superconducting magnets, FRESCA2 cable test facility, accelerator magnets, tin alloys
Abstract

International audience; The Nb$_3$Sn block coil dipole magnet FRESCA2 was developed within the framework of a collaboration between CEA Saclay and CERN, in the continuity of the European project EuCARD and EuCARD2. With an aperture of 100 mm and a target bore field of 13 T at 10.6 kA, the magnet is required for a new FRESCA2 cable test facility at CERN. In 2017, the magnet was pre-loaded to retain the forces while the magnet was powered to achieve 13.3 T in the magnet bore. Results of these tests were published. In 2018, the loading of the magnet has been increased for powering to higher current. In this paper, the updated results of the cold powering tests are discussed in terms of training, memory, and stable operation. The loading of the magnet and the mechanical measurements during cooldown are shown and compared to the earlier loading steps. The protection of the magnet is further reviewed and measured results are compared to the model simulations.

Published
2019
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111. Implication of NOD-1 receptor in house dust mite (HDM)-induced asthma

Author

Philippe Marquillies, Daniel Alvarez-Simon, S. Ait Yahia, Han Vorng, Camille Audousset, Aline Rifflet, Mathias Chamaillard, Anne Tsicopoulos, Myriam Delacre, and I. Gomperts Boneca

Subjects
Pulmonary and Respiratory Medicine, House dust mite, Chemokine, biology, Kinase, Chemistry, Stimulation, Nod, medicine.disease, biology.organism_classification, respiratory tract diseases, body regions, RIPK2, Immunology, medicine, biology.protein, Receptor, Asthma
Abstract

Introduction NOD1 is an innate pattern-recognition sensor for Gram-negative peptidoglycan (PG) that is involved in the development of allergic asthma and signals through the kinase RIPK2. The aim of this study was to investigate the role of NOD1 in HDM-induced asthma. Methods Nod1-/-, Ripk2-/− and WT mice were subjected to a protocol of HDM-induced asthma. Faecal microbiota transplantation from Nod1-/− and WT was performed in germ free (GF) mice before HDM asthma protocol. HDM content was analysed by mass spectrometry. A NOD1 reporter cell model and the human bronchial epithelial cell line Beas2B were stimulated with HDM. Results Nod1-/− and Ripk2-/− mice exhibited reduced asthma features, including decreased airway hyperresponsiveness (AHR), less pulmonary inflammation and lower levels of Th2-related cytokines and chemokines. However, no differences in any asthma parameters were found between GF mice transplanted with either Nod1-/− or WT microbiota. HDM mass spectrometry analysis evidenced the presence of PG-derived NOD1 ligands, and a PG-dependent activation was found in the NOD1 reporter model. Furthermore, the HDM stimulation of human epithelial Beas2B cells led to NOD1 activation and RIPK2 signalling. Accordingly, when WT mice were subjected to the asthma protocol with PG-depleted HDM, but not to LPS-reduced HDM, asthma features were notably reduced. Conclusions HDM-derived microbiota promotes allergic airway disease through NOD1 sensing, suggesting that this pathway may provide attractive therapeutic targets.

Published
2021
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112. Cryogenic tests of the first two LHC quadrupole prototypes

Author

Genevey, P., Deregel, J., Perot, J., Rifflet, J.M., Vedrine, P., Cortella, J., Coroller, A. Le, Rodriguez-Mateos, F., Tortschanoff, T., Siegel, N., and Verweij, A.P.

Subjects
Superconducting magnets -- Testing, Business, Electronics, Electronics and electrical industries
Abstract

The results of cryogenic, mechanical, pressure and electrical tests on two twin-aperture quadrupole prototypes designed for the Large Hadron Collider are presented. The superconducting magnets, which were built by the European Organization for Nuclear Research and France's CEA Saclay, were tested in their powering, ramping, cool-down, stand-by, quenching and warming-up states. Based on the results, the two quadrupoles can attain a nominal current of 15,060 A with 'little training.'

Published
1995

113. Mechanical tests on the prototype LHC lattice quadrupole

Author

Vedrine, P., Rifflet, J.M., Perot, J., Gallet, B., Lyraud, C., Giovannoni, P., Le Coz, F., Siegel, N., and Tortschanoff, T.

Subjects
Ion accelerators -- Research, Lattice dynamics -- Research, Superconducting magnets -- Research, Business, Electronics, Electronics and electrical industries
Abstract

A prototype twin superconducting quadrupole magnet for the Large Hadron Collider (LHC) is being developed and built at CEN/Saclay in collaboration with CERN. This paper describes the mechanical tests performed to validate the main concepts of the mechanical design in order to meet the requirements of prestress while maintaining a precise geometrical shape of the coils. Moulding tests on samples of superconducting cables have been made in order to evaluate the final size of the coils after curing and under stress. Collaring tests have been made on small length models to verify the process and the resulting prestress. The principal results and conclusions of the tests are summarized.

Published
1994

114. Status of the fabrication and test of the prototype LHC lattice quadrupole magnets

Author

Rifflet, J.M., Giovannoni, P., Le Coz, F., Lyraud, C., Perot, J., Vedrine, P., Siegel, N., and Tortschanoff, T.

Subjects
Magnets -- Research, Ion accelerators -- Research, Business, Electronics, Electronics and electrical industries
Abstract

Within the framework of the Large Hadron Collider (LHC) R&D program, CERN and CEN/Saclay have established a collaboration to carry out, amongst others, the design, building, and testing of a superconducting LHC prototype quadrupole at the Saclay laboratory. The twin aperture prototype, working in liquid helium at 1.8 K, has a gradient of 250 T/m, is about 3.2 m long, with a coil aperture of 56 mm. This paper describes the present state of the R&D work for the quadrupole magnet, reviewing the fabrication and validation tests of the design.

Published
1994

115. Mechanical, thermal and electromagnetic design of a superconducting quadrupole for the SSC

Author

Orrell, D., Turner, J., Giavonnoni, P., Kircher, F., Lyraud, C., Perot, J., Rifflet, J.M., and Vedrine, P.

Subjects
Superconducting magnets -- Research, Business, Electronics, Electronics and electrical industries, Superconducting Super Collider -- Research
Abstract

As part of a collaboration with the SSC, CEA/Saclay has designed a superconducting quadrupole magnet for the High Energy Booster ring. A number of prototypes are being built at Saclay, after which the production will be handed over to an American firm. This paper presents the mechanical, thermal and electromagnetic analyses which have been performed during the design of the magnet.

Published
1994

117. Development of an Innovative Wide Aperture Vector Magnet: WAVE

Author

S. Klimko, F. Nunio, T. Robillard, A. M. Bataille, J. M. Rifflet, A. Peugeot, C. Berriaud, P. Bredy, D. Simon, G. Aubert, A. Dael, J. L. Meuriot, and P. Lavie

Subjects
Physics, Diffraction, Condensed matter physics, 010308 nuclear & particles physics, business.industry, Neutron diffraction, Superconducting magnet, Neutron scattering, Cryocooler, Condensed Matter Physics, 01 natural sciences, Electronic, Optical and Magnetic Materials, Optics, Dipole magnet, Magnet, 0103 physical sciences, Electromagnetic shielding, Electrical and Electronic Engineering, 010306 general physics, business
Abstract

WAVE is a 1-T vector magnet for neutron scattering experiments. It will expand the range of experimental possibilities since applying a 3-D magnetic field and orienting the sample in diffraction conditions will become completely independent. The WAVE magnet is made of 16 coils, all with a vertical axis. The vertical component of the field is produced by four flat coils (two coils in quasi-Helmholtz position and two coils for active shielding), whereas the horizontal components are generated by three sets of four coils each, i.e., two above and two below the diffraction plane connected in an antisymmetric way. The very wide aperture (220° horizontal, ±10° vertical) is crucial for neutron diffraction and inelastic neutron scattering experiments. The homogeneity of the field is in the range of 500 ppm, and the diameter of the sample bore is large (100 mm). The design concepts of WAVE are NbTi solenoids imbedded in an aluminum box, indirectly cooled by liquid helium circulating in a thermosiphon loop and exchanging with a cryocooler. The WAVE coils are energized by four current supplies through HTS current leads. WAVE will be used as a sample environment on neutron scattering instruments relevant for magnetism studies and thus available to a large community of users. This equipment, which is based on an innovative design (Patent FR12 62 070, US extension 14/105,711), is developed with an industrial partner. The magnet will be commissioned in 2017.

Published
2016
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118. Geometrical Behavior of Nb3Sn Rutherford Cables During Heat Treatment

Author

Paolo Ferracin, J. M. Rifflet, F. Rondeaux, Juan Carlos Perez, Maria Durante, Pierre Manil, and Laura Garcia Fajardo

Subjects
Nuclear magnetic resonance, Materials science, Condensed matter physics, 0103 physical sciences, Electrical and Electronic Engineering, 010306 general physics, Condensed Matter Physics, 01 natural sciences, Electronic, Optical and Magnetic Materials
Published
2016
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119. 'Block-Type' Coils Fabrication Procedure for the Nb3Sn Dipole Magnet FRESCA2

Author

Etienne Rochepault, J. M. Rifflet, Paolo Ferracin, G. de Rijk, Marco Durante, Jimena Perez, Remy Gauthier, F. Rondeaux, Pierre Manil, S. Sequeira Tavares, and J. E. Munoz Garcia

Subjects
Large Hadron Collider, Fabrication, Materials science, Aperture, Instrumentation, Mechanical engineering, Superconducting magnet, Condensed Matter Physics, 01 natural sciences, Electronic, Optical and Magnetic Materials, Nuclear magnetic resonance, Dipole magnet, Electromagnetic coil, Magnet, 0103 physical sciences, Physics::Accelerator Physics, Electrical and Electronic Engineering, 010306 general physics
Abstract

The Nb3Sn FRESCA2 dipole magnet is dedicated to upgrade the CERN cable test facility FRESCA. It is also a technological demonstrator of large-aperture Nb3Sn accelerator magnet. It has an aperture of 100 mm and a target bore magnetic field of 13 T. It is composed of four 1.5-m-long double-pancake “block-type” coils, manufactured following the wind, react and impregnation technique. It is developed by CEA and CERN in the framework of a collaboration agreement, in the continuity of the EuCARD program. Through the fabrication of two full-scale copper prototypes, the different steps of the coil fabrication process (winding, heat treatment, splicing, instrumentation, impregnation, and transport) and the corresponding tooling have been adjusted. The final winding and reaction procedure integrates the possibility to open longitudinal gaps in the winding table and in the central post, in order to accommodate partially the longitudinal contraction of the cable during reaction. This new feature has been experienced through full-scale tests using superconducting cable with a reduced number of turns. This paper reports on the fabrication procedure of these coils. The production phase of the superconducting magnets has started in June 2015.

Published
2016
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122. Ultrasonographic diagnosis of hepatic fibrosis or cirrhosis

Author

Aubé, Christophe, Oberti, Frédéric, Korali, Nouri, Namour, Marc-Antoine, Loisel, Didier, Tanguy, Jean-Yves, Valsesia, Emmanuelle, Pilette, Christophe, Rousselet, Marie Christine, Bedossa, Pierre, Rifflet, Hervé, Maïga, Moussa Y., Penneau-Fontbonne, Dominique, Caron, Christine, and Calès, Paul

Published
1999

123. Possible zoonotic transmission of hepatitis E from pet pig to its owner

Author

Renou, Christophe, Cadranel, Jean-Francois, Bourliere, Marc, Halfon, Philippe, Ouzan, Denis, Rifflet, Herve, Carenco, Philippe, Harafa, Abdelouahid, Bertrand, Jean Jacques, Boutrouille, Annie, Muller, Pierre, Igual, Jean-Pierre, Decoppet, Anne, Eloit, Marc, and Pavio, Nicole

Subjects
Pets -- Health aspects, Hepatitis -- Health aspects, Infection -- Health aspects, Swine -- Health aspects
Abstract

Hepatitis E is transmitted mainly by water or food, but in industrialized countries, all routes of transmission have not been identified. We describe possible zoonotic transmission of hepatitis E virus [...]

Published
2007

124. Status of the 16 T Dipole Development Program for a Future Hadron Collider

Author

Fernando Toral, Carlo Petrone, Friedrich Lackner, Bernhard Auchmann, Etienne Rochepault, Giovanni Bellomo, Juan Carlos Perez, Maria Durante, Marco Prioli, Carmine Senatore, Hugues Bajas, Soren Prestemon, Ezio Todesco, Stephan Russenschuck, Paolo Ferracin, Davide Tommasini, Rafal Ortwein, Gijs DeRijk, Susana Izquierdo Bermudez, Toru Ogitsu, Michael Benedikt, Daniel Schoerling, Diego Arbelaez, Barbara Caiffi, Massimo Sorbi, Peng Gao, Shlomo Caspi, Stefania Farinon, Amalia Ballarino, Igor Novitski, Michel Segreti, Javier Munilla, Antti Stenvall, Maxim Marchevsky, Vadim Kashikhin, Clement Lorin, Emanuela Barzi, Teresa Martinez, Marco Buzio, Luca Bottura, Mariusz Juchno, Vittorio Marinozzi, Marc Dhalle, Marta Bajko, Tiina Salmi, Lucas Brower, J. M. Rifflet, S. Wessel, Frederic Savary, S.A. Gourlay, Felix Wolf, Bernardo Bordini, Alexander V. Zlobin, Arjan Verweij, Pasquale Fabbricatore, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Senatore, Carmine, and Energy, Materials and Systems

Subjects
General Physics, magnet: design, superconducting, accelerator, Aperture, Physics::Instrumentation and Detectors, ++%24%5F{3}%24<%2Ftex-math>+<%2Finline-formula>+<%2Fnamed-content>Sn%22">Nb $_{3}$ Sn, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Superconducting magnet, ddc:500.2, 16 T, 7. Clean energy, 01 natural sciences, Future Circular Collider, beam: energy, Nuclear physics, Affordable and Clean Energy, 0103 physical sciences, CERN LHC Coll: upgrade, Future circular collider, Nb3Sn, FCC, Future circular collider (FCC), Electrical and Electronic Engineering, 010306 general physics, activity report, 010302 applied physics, Physics, Large Hadron Collider, beam: width, Materials Engineering, magnet: superconductivity, magnet: technology, Condensed Matter Physics, 22/4 OA procedure, bending magnet, Electronic, Optical and Magnetic Materials, Dipole, Automatic Keywords, Upgrade, quality, Magnet, Physics::Accelerator Physics, High Energy Physics::Experiment, Center of mass, hadron, dipole
Abstract

© 2017 IEEE. Personal use is permitted, but republication/redistribution requires IEEE permission. A next step of energy increase of hadron colliders beyond the LHC requires high-field superconducting magnets capable of providing a dipolar field in the range of 16 T in a 50-mm aperture with accelerator quality. These characteristics could meet the requirements for an upgrade of the LHC to twice the present beam energy or for a 100-TeV center of mass energy future circular collider. This paper summarizes the activities and plans for the development of these magnets, in particular within the 16 T Magnet Technology Program, the WP5 of the EuroCirCol, and the U.S. Magnet Development Program.

Published
2018
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125. Tests of the FRESCA2 100 mm Bore Nb3Sn Block-Coil Magnet to a Record Field of 14.6 T

Author

Willering, Gerard, primary, Arnestad, Havard, additional, Bajko, Marta, additional, Bajas, Hugo, additional, Bortot, Lorenzo, additional, Bottura, Luca, additional, Bourcey, Nicolas, additional, Duda, Michal, additional, Ferracin, Paolo, additional, Feuvrier, Jerome, additional, Grosclaude, Philippe, additional, Mangiarotti, Franco, additional, Martins Araujo, Douglas, additional, Perez, Juan Carlos, additional, Petrone, Carlo, additional, Rochepault, Etienne, additional, de Rijk, Gijs, additional, Turi, Daniel, additional, Durante, Maria, additional, Manil, Pierre, additional, Rondeaux, Francoise, additional, and Rifflet, Jean-Michel, additional

Published
2019
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126. The impact of gut microbiota on depressive-like behaviors and adult hippocampal neurogenesis requires the endocannabinoid system

Author

Chevalier, Grégoire, primary, Siopi, Eleni, additional, Guenin-Macé, Laure, additional, Pascal, Maud, additional, Laval, Thomas, additional, Rifflet, Aline, additional, Boneca, Ivo Gomperts, additional, Demangel, Caroline, additional, Leulier, François, additional, Lepousez, Gabriel, additional, Eberl, Gérard, additional, and Lledo, Pierre-Marie, additional

Published
2019
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135. Mechanical Validation of the Support Structure of the <tex-math notation='TeX'>$\hbox{Nb}_{3}\hbox{Sn}$</tex-math> Magnet FRESCA2

Author

J. C. Perez, J. M. Rifflet, Pierre Manil, D. T. Ziemianski, G. de Rijk, Marta Bajko, Hugues Bajas, Paolo Ferracin, F. Rondeaux, Michael Guinchard, Vladimir Datskov, Marco Durante, M. Charrondiere, and J. E. Munoz Garcia

Subjects
Materials science, Superconducting magnet, Cryogenics, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Cylinder (engine), law.invention, Stress (mechanics), chemistry.chemical_compound, Nuclear magnetic resonance, chemistry, Dipole magnet, law, Magnet, Electrical and Electronic Engineering, Niobium-tin, Composite material, Strain gauge
Abstract

FRESCA2 is a dipole magnet dedicated to upgrade the present CERN cable test station FRESCA to a nominal bore field of 13 Tesla (T) in a 100 mm clear aperture. This paper reports on the assembly process and the three cool-down tests to cryogenic temperature of the support structure of FRESCA2. This structure is based on an aluminum alloy shrinking cylinder pre-loaded through the use of water-pressurized bladders. To verify the assembly and loading processes, this structure was assembled using full block aluminum alloy “dummy coils” standing for the Nb 3 Sn coils. Then, the whole assembled structure was cooled-down to 77 K with liquid nitrogen in a dedicated facility at CERN. The mechanical behavior was monitored at all stages by strain gauges located on different components of the structure. Three cryogenic tests were made by increasing the loading gradually up to values corresponding to the ultimate field of 15 T. The expected stresses within the structure after assembly, loading and cool-down were determined from the 3-D finite-element model of the support structure. A comparison of the model predictions with the strain gauge data is presented.

Published
2015
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136. A Nb-Ti 90 mm Double-Aperture Quadrupole for the High Luminosity LHC Upgrade

Author

J.M. Rifflet, E. Todesco, and M. Segreti

Subjects
Physics, Large Hadron Collider, Luminosity (scattering theory), Physics::Instrumentation and Detectors, Aperture, Magnetic lattice, Superconducting magnet, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, Nuclear physics, Electromagnetic coil, Magnet, Quadrupole, Physics::Accelerator Physics, Electrical and Electronic Engineering
Abstract

The luminosity upgrade of the LHC requires replacing the magnets around the ATLAS and CMS experiments with larger aperture dipoles, quadrupoles and correctors. The goal is to have a magnetic lattice that can allow to halve the beam size in the collision points with respect to present baseline. Within the framework of HiLumi LHC, CEA-Saclay studied the replacement of the 70-mm double aperture quadrupole Q4, with a 90-mm magnet based on Nb-Ti technology. The main challenges are due to the distance between the beams of 194 mm, giving a non-negligible magnetic coupling between the two apertures. The coil chosen to be the baseline is a single layer with 15-mm-width cable of the LHC MQ quadrupole. The mechanical structure is based on stainless steel collars to withstand the Lorentz forces. The iron yoke has a magnetic function, and guarantees the alignment of the two apertures. Electromagnetic and mechanical aspects and effects of unbalanced regimes on the field quality have been analyzed. A 3-D design of the coil ends is obtained by minimizing both the integrated multipoles and the peak field.

Published
2015
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137. Cos- <tex-math notation='TeX'>$\theta$</tex-math> Design of Dipole Inserts Made of REBCO-Roebel or BSCCO-Rutherford Cables

Author

J. M. Rifflet, Luca Bottura, Lucio Rossi, Chhon Pes, Amalia Ballarino, Michel Segreti, Clement Lorin, Philippe Fazilleau, Glyn Kirby, Maria Durante, Jeroen van Nugteren, and J. Fleiter

Subjects
Superconductivity, Insert (composites), High-temperature superconductivity, Materials science, Magnetic moment, Mechanical engineering, Superconducting magnet, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, law.invention, Dipole, Nuclear magnetic resonance, Dipole magnet, law, Magnet, Electrical and Electronic Engineering
Abstract

Next generation of dipole magnets with a field higher than 16 T are considered for future particle colliders. To do so, combined-technology magnets, made of Nb-Ti, Nb3Sn and high-temperature superconductor (HTS) materials, have to be developed to reduce the cost of such a magnet. Therefore, in the framework of the European Coordination for Accelerator Research and Development (EuCARD-2) project, many HTS dipole magnet designs have to be investigated to find the most effective design for the HTS insert in a graded magnet. This paper discusses the cos θ option. A 5-T stand-alone configuration of the HTS accelerator magnet (the first goal of EuCARD-2) appears to be achievable, whereas mechanical stress distribution shows that its use as an insert in a graded magnet is very challenging. This paves the way for alternative designs as the so-called slot or motor-like design, which is briefly introduced here.

Published
2015
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139. Possible Zoonotic Transmission of Hepatitis E from Pet Pig to Its Owner

Author

Christophe Renou, Jean-Francois Cadranel, Marc Bourlière, Philippe Halfon, Denis Ouzan, Hervé Rifflet, Philippe Carenco, Abdelouahid Harafa, Jean Jacques Bertrand, Annie Boutrouille, Pierre Muller, Jean-Pierre Igual, Anne Decoppet, Marc Eloit, and Nicole Pavio

Subjects
Hepatitis E virus, zoonosis, transmission pathway, dispatch, France, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

Hepatitis E is transmitted mainly by water or food, but in industrialized countries, all routes of transmission have not been identified. We describe possible zoonotic transmission of hepatitis E virus that involved direct contact between a pet pig and its owner.

Published
2007
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140. Development of a Nb3Sn quadrupole magnet model

Author

Devred, A., Durante, M., Gourdin, C., Juster, F.P., Peyrot, M., Rey, J.M., Rifflet, J.M., Streiff, F., and Vedrine, P.

Subjects
Superconducting magnets -- Models, Business, Electronics, Electronics and electrical industries
Abstract

The development of a Nb3Sn quadrupole magnet model is described and the results of NbTi-Nb3Sn cable splice tests are presented.

Published
2001

141. Assembly of the Nb$_{3}$Sn dipole magnet FRESCA2

Author

Jose Ferradas, Francois Olivier Pincot, Juan Carlos Perez, Philippe Grosclaude, Gijs de Rijk, Maria Durante, Nicolas Peray, Remy Gauthier, Alejandro Carlon Zurita, Pierre Manil, Paolo Ferracin, Nicolas Bourcey, Etienne Rochepault, J. M. Rifflet, F. Rondeaux, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
Materials science, CERN Lab, magnet: design, Ignition coil, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Mechanical engineering, Superconducting magnet, fabrication, 7. Clean energy, 01 natural sciences, chemistry.chemical_compound, Dipole magnet, 0103 physical sciences, Electrical and Electronic Engineering, Niobium-tin, 010306 general physics, 010302 applied physics, Large Hadron Collider, magnet: superconductivity, Condensed Matter Physics, bending magnet, Electronic, Optical and Magnetic Materials, Dipole, chemistry, Electromagnetic coil, Magnet, niobium: tin
Abstract

International audience; The Nb$_{3}$Sn dipole magnet FRESCA2 has been developed and manufactured within the framework of a collaboration between the Centre for Atomic Energy (CEA Saclay) and the European Organization for Nuclear Research (CERN). The aim of the magnet is to upgrade the superconducting cable test station at CERN with a Nb$_{3}$Sn dipole providing a 13-T magnetic field in a 100-mm aperture. The magnet is composed of four coils in a block-type configuration with flared ends, 1.6 m long, housed in a bladder, and key-type mechanical structure. A first assembly of the magnet, FRESCA2a, has been done at CERN at the end of 2016 with the four first Nb$_{3}$Sn coils fabricated at CEA Saclay and CERN. The coils were dimensionally measured, and tailored shims were fabricated and inserted in the coil pack to improve the contact between layers. In addition, tests with pressure sensitive films were carried out to verify the uniformity of the loading. The magnet was cold tested in February 2017 and dismounted to replace one coil. A second assembly, FRESCA2b, was produced and tested in August 2017. In this paper, we provide a detailed description of the various steps of the assembly from the impregnated coils to the delivery of the dipole to the test facility, with a particular emphasis on the procedures followed and the tooling developed.

Published
2017
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142. Development of MQYY: A 90-mm NbTi Double Aperture Quadrupole Magnet for HL-LHC

Author

Nicolas Bourcey, Ezio Todesco, Damien Simon, O. Dunkel, Pawel Krawcyzk, Patrick Graffin, Arnaud Foussat, Arnaud Madur, Henri Salvador, Lucio Fiscarelli, Hector Garcia Gavela, Denis Bouziat, Helene Felice, Juan Carlos Perez, M. Losasso, Fernando Toral, J. Fleiter, Jean Marc Gheller, Jean Francois Millot, Isabel Bejar Alonso, Michel Segreti, Jean Michel Rifflet, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Département des Accélérateurs, de Cryogénie et de Magnétisme (ex SACM) (DACM), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
Materials science, Fabrication, CERN Lab, Aperture, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], quadrupole lens: design, Mechanical engineering, Context (language use), Superconducting magnet, fabrication, 01 natural sciences, 0103 physical sciences, CERN LHC Coll: upgrade, Electrical and Electronic Engineering, niobium: titanium, 010306 general physics, Quadrupole magnet, 010302 applied physics, Beam diameter, Large Hadron Collider, beam: width, magnet: superconductivity, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, quadrupole lens, Automatic Keywords, CERN LHC Coll, Cold test
Abstract

International audience; In the context of the HL-LHC project, a NbTi double aperture quadrupole magnet called MQYY is being developed. This 90-mm-aperture quadrupole magnet has a magnetic length of 3.67 m and an operating gradient of 120 T/m at 1.9 K. Its development is done along two parallel paths: 1) the design, fabrication, and test of a short model; 2) the design and fabrication of two full-scale prototypes in industry within the H2020 EU Pre-Commercial Procurement project QUACO implemented by CERN, CEA, CIEMAT, and NCBJ. We report here on the short-model design choices the status of its fabrication and the preparation of the tests. In particular, we describe the magnetic and mechanical design relying on self-supporting collars, the protection aspects, the fabrication, and the cold test preparation. Finally, we present the unusual scheme of the QUACO project leading to the prototypes fabrication.

Published
2017
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143. Cold Powering Tests and Protection Studies of the FRESCA2 100 mm Bore Nb$_{3}$Sn Block-Coil Magnet

Author

J. C. Perez, Nicolas Bourcey, F. Rondeaux, L. Bottura, Etienne Rochepault, Michal Duda, Philippe Grosclaude, Carlo Petrone, Franco Mangiarotti, J. Feuvrier, G. de Rijk, Bernardo Bordini, Hugues Bajas, Maria Durante, J. M. Rifflet, Paolo Ferracin, Marta Bajko, Gerard Willering, P. Manil, and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
010302 applied physics, Rutherford cable, Large Hadron Collider, Materials science, Aperture, Nuclear engineering, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Magnetic separation, Superconducting magnet, Condensed Matter Physics, 01 natural sciences, Electronic, Optical and Magnetic Materials, Electromagnetic coil, Dipole magnet, Magnet, 0103 physical sciences, Electrical and Electronic Engineering, 010306 general physics
Abstract

International audience; The Nb3Sn block-coil dipole magnet FRESCA2 was developed within the framework of a collaboration between CEA Saclay and CERN, follow up of the European project EuCARD. The magnet is aimed at upgrading the cable test facility at CERN to a bore field of 13 T at 10.6 kA in an aperture of 100 mm as deliverable. The design features four 1.6-m-long double-layer coils wound with a 40 strand, 21-mm-wide Rutherford cable. The first assembly was limited at 12.2 T with a known production defect of the cable close to a splice in one of the coils. Following replacement of this coil, the second assembly reached the target for this run of 13.3 T. In this paper, the performance of the assemblies in terms of training behavior, quench detection, protection, magnetic measurements, and other cold powering tests will be discussed.

Published
2017
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144. Mechanical Analysis of the FRESCA2 Dipole During Preload, Cool-Down, and Powering

Author

Gerard Willering, Etienne Rochepault, Nicolas Bourcey, Michael Guinchard, Gijs de Rijk, Juan Carlos Perez, Pierre Manil, Philippe Grosclaude, F. Rondeaux, Paolo Ferracin, J. M. Rifflet, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay

Subjects
Materials science, CERN Lab, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Mechanical engineering, Superconducting magnet, 01 natural sciences, Rod, law.invention, Dipole magnet, law, 0103 physical sciences, coil, helium: liquid, Electrical and Electronic Engineering, 010306 general physics, Strain gauge, 010302 applied physics, Large Hadron Collider, Liquid helium, beam: width, temperature, Condensed Matter Physics, magnet, bending magnet, Electronic, Optical and Magnetic Materials, Dipole, Automatic Keywords, Magnet, dipole
Abstract

International audience; The FRESCA2 dipole magnet is being developed within a collaboration between CEA Saclay and CERN. The main goal of the magnet is to provide a 13 T nominal bore field into a clear aperture of 100 mm diameter, for the second generation cable test facility FRESCA2 at CERN. Two magnet assemblies have been done with different coils. The assemblies have been preloaded at room temperature, cooled-down in liquid helium, and powered with several current cycles. The magnet is mechanically instrumented with strain gauges on the external shell, tie rods, and central post of the coils. Strain data are compared with a 3-D mechanical model, in order to validate different assumptions such as friction coefficients, material properties, and prestress levels. This paper reports the results of the mechanical measurements collected during preload, cool-down, powering, and warm-up of the magnet.

Published
2017
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145. LHC IR Upgrade Nb–Ti, 120-mm Aperture Model Quadrupole Test Results at 1.8 K

Author

Ezio Todesco, C. Giloux, T. Sahner, Paolo Fessia, M. Segreti, Pier Paolo Granieri, Marta Bajko, Michael Guinchard, Marco Durante, Bernhard Auchmann, J. M. Rifflet, Glyn Kirby, J. Feuvrier, J. C. Perez, Gerard Willering, Emmanuele Ravaioli, Vladimir Datskov, Pierre Manil, and Stephan Russenschuck

Subjects
Materials science, Large Hadron Collider, Aperture, Instrumentation, Nuclear engineering, Superconducting magnet, Condensed Matter Physics, Accelerators and Storage Rings, Electronic, Optical and Magnetic Materials, Nuclear magnetic resonance, Upgrade, Heat flux, Harmonics, Magnet, Electrical and Electronic Engineering
Abstract

Over the last five years, the model MQXC quadruple, a 120-mm aperture, 120 T/m, 1.8 m long, Nb-Ti version of the LHC insertion upgrade (due in 2021), has been developed at CERN. The magnet incorporates several novel concepts to extract high levels of heat flux and provide high quality field harmonics throughout the full operating current range. Existing LHC-dipole cable with new, open cable and ground insulation was used. Two, nominally identical 1.8-m-long magnets were built and tested at 1.8 K at the CERN SM18 test facility. This paper compares in detail the two magnet tests and presents: quench performance, internal stresses, heat extraction simulating radiation loading in the superconducting coils, and quench protection measurements. The first set of tests highlighted the conflict between high magnet cooling capability and quench protection. The second magnet had additional instrumentation to investigate further this phenomenon. Finally, we present test results from a new type of superconducting magnet protection system.

Published
2014
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146. Development and Coil Fabrication Test of the $ \hbox{Nb}_{3}\hbox{Sn}$ Dipole Magnet FRESCA2

Author

Leticia García, J. C. Perez, S. Clement, S. Pietrowicz, J. M. Rifflet, M. Devaux, Ezio Todesco, G. de Rijk, Paolo Ferracin, Bertrand Baudouy, J. E. Munoz Garcia, Marco Durante, L.R. Oberli, Remy Gauthier, Pierre Manil, F. Rondeaux, Paolo Fessia, and P. Fazilleau

Subjects
Fabrication, Materials science, Aperture, Full scale, Mechanical engineering, Superconducting magnet, Condensed Matter Physics, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, Nuclear magnetic resonance, chemistry, Electromagnetic coil, Dipole magnet, Magnet, Electrical and Electronic Engineering, Niobium-tin
Abstract

The key objective of the High Field Magnet work package of the European Project EuCARD is to design and fabricate the Nb3Sn dipole magnet FRESCA2. It has an aperture of 100 mm and a target bore field of 13 T. The design features four 1.5 m long double-layer coils wound with a 21 mm wide cable. The project has now entered its experimental phase in view of the magnet fabrication. We present the experimental test campaign conducted on cable samples in order to understand and to control better the cable behavior and geometry. One full scale double-layer coil using copper cable with the final dimensions and insulation scheme has been wound and heat treated in order to check the fabrication process. This has given useful feedback on the fabrication procedure and on the expected magnet dimensions, as well as on the tooling itself.

Published
2014
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147. Eradications as scientific experiments: progress in simultaneous eradications of two major invasive taxa from a Mediterranean island

Author

Elise Krebs, Marine Pascal, Coralie Santelli, Frédéric Médail, Lenka Brousset, Laurence Affre, P. Gillet, Patricia Le Quilliec, François Rifflet, Lise Ruffino, Annie Aboucaya, Jean-Yves Meunier, Aurélie Passetti, Yannick Limouzin, Nathalie Bigeard, Elise Buisson, Damien Fourcy, Olivier Lorvelec, Hélène De Meringo, Eric Vidal, Michel Pascal, Philippe Ponel, Alain Barcelo, and Laurence Berville

Subjects
0106 biological sciences, Nature reserve, Mediterranean climate, education.field_of_study, biology, Agroforestry, Ecology, 010604 marine biology & hydrobiology, Biosecurity, Population, Carpobrotus, Biodiversity, General Medicine, 15. Life on land, Native plant, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Carpobrotus edulis, Insect Science, 14. Life underwater, education, Agronomy and Crop Science
Abstract

Black rats, Rattus rattus, and mat-forming iceplants, Carpobrotus aff. acinaciformis and Carpobrotus edulis, are pervasive pests on Mediterranean islands. Their cumulative impacts on native biotas alter the functioning of island ecosystems and threaten biodiversity. A report is given here of the first attempt to eradicate both taxa from a protected nature reserve in south-eastern France (Bagaud Island). In order to minimise unwanted hazardous outcomes and produce scientific knowledge, the operations were embedded in a four-step strategy including initial site assessment, planning, restoration and monitoring.[br/] Trapping, which resulted in the removal of 1923 rats in 21 045 trap-nights, made it possible to eliminate a substantial proportion of the resident rat population and to reduce the amount of rodenticide delivered in the second stage of the operation. Forty tons of Carpobrotus spp. were manually uprooted from a total area of 18 000 m(2) ; yet careful monitoring over a decade is still required to prevent germinations from the seed bank.[br/] Two years after the beginning of the interventions, both eradication operations are still ongoing. Biosecurity measures have been implemented to reduce reinvasion risks of both taxa. With the long-term monitoring of various native plants and animals, Bagaud Island will become a reference study site for scientific purposes.

Published
2014
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149. Cold Powering Tests and Protection Studies of the FRESCA2 100 mm Bore Nb3Sn Block-Coil Magnet

Author

Willering, G., primary, Petrone, C., additional, Bajko, M., additional, Bajas, H., additional, Bordini, B., additional, Bottura, L., additional, Bourcey, N., additional, Duda, M., additional, Ferracin, P., additional, Feuvrier, J., additional, Grosclaude, P., additional, Mangiarotti, F., additional, Perez, J. C., additional, Rochepault, E., additional, de Rijk, G., additional, Durante, M., additional, Manil, P., additional, Rondeaux, F., additional, and Rifflet, J. M., additional

Published
2018
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150. Assembly of the Nb3Sn Dipole Magnet FRESCA2

Author

Bourcey, Nicolas, primary, Zurita, Alejandro Carlon, additional, Durante, Maria, additional, Ferracin, Paolo, additional, Ferradas, Jose, additional, Gauthier, Remy, additional, Grosclaude, Philippe, additional, Manil, Pierre, additional, Peray, Nicolas, additional, Perez, Juan Carlos, additional, Pincot, Francois Olivier, additional, Rifflet, Jean-Michel, additional, de Rijk, Gijs, additional, Rochepault, Etienne, additional, and Rondeaux, Francoise, additional

Published
2018
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