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101. A lethal role for lipid A in Salmonella infections

Author

Khan, Shahid A., Everest, Paul, Servos, Spiros, Foxwell, Neale, Zähringer, Ulrich, Brade, Helmut, Rietschel, Ernst Th., Dougan, Gordon, Charles, Ian G., and Maskell, Duncan J.

Published
1998

104. Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients

Author

Paul Karl, Ballmann Manfred, Schmidt Reinhold, Essl Robert, Griese Matthias, Rietschel Ernst, and Ratjen Felix

Subjects
Surfactant protein, phospholipids, surface activity, pulsating bubble, capillary surfactometer, bronchoalveolar lavage, airway inflammation, lung function, Diseases of the respiratory system, RC705-779
Abstract

Abstract Background In a cross-sectional analysis of cystic fibrosis (CF) patients with mild lung disease, reduced surfactant activity was correlated to increased neutrophilic airway inflammation, but not to lung function. So far, longitudinal measurements of surfactant function in CF patients are lacking and it remains unclear how these alterations relate to the progression of airway inflammation as well as decline in pulmonary function over time. Methods As part of the BEAT trial, a longitudinal study to assess the course of airway inflammation in CF, we studied lung function, surfactant function and endobronchial inflammation using bronchoalveolar lavage fluid from 20 CF patients with normal pulmonary function (median FEV1 94% of predicted) at three times over a three year period. Results There was a progressive loss of surfactant function, assessed as minimal surface tension. The decline in surfactant function was negatively correlated to an increase in neutrophilic inflammation and a decrease in lung function, assessed by FEV1, MEF75/25%VC, and MEF25%VC. The concentrations of the surfactant specific proteins A, C and D did not change, whereas SP-B increased during this time period. Conclusion Our findings suggest a link between loss of surfactant function driven by progressive airway inflammation and loss of small airway function in CF patients with limited lung disease.

Published
2005
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105. Antibiotika-Forschung - 5 Jahre danach: Was hat sich getan, was bleibt zu tun?

Author

Deutsche Akademie Der Naturforscher Leopoldina, Akademie Der Wissenschaften (Hamburg), Addo, Marylyn, Breuer, Constanze, Fleischer, Bernhard, Gr��ger, Thomas, Hammann, Peter, Happe, Kathrin, Hecker, Michael, Lohse, Ansgar, Mettenleiter, Thomas, M��ller, Rolf, Rietschel, Ernst, R��bsamen-Schaeff, Helga, Sahl, Hans-Georg, Solbach, Werner, Wieler, Lothar, Zabel, Peter, and Senne, Elke

Subjects
Pharmazie, Antibiotikaresistenz, Immunologie, Antibiotikum
Abstract

Einer stetig zunehmenden Zahl von Infektionen durch Antibiotika-resistente Bakterien stehen immer weniger neue Antibiotika gegen��ber - das ���Antibiotika-Problem���. Aus diesem Anlass ver��ffentlichten die Leopoldina und die Akademie der Wissenschaften in Hamburg im Jahr 2013 die Stellungnahme ���Antibiotika-Forschung: Probleme und Perspektiven���, die auf einen Workshop 2012 zur��ckging. Mit dem vorliegenden Papier weisen die Akademien nun ��� 5 Jahre nach dem ersten Workshop - auf eine Reihe von Punkten hin, welche aus Sicht der Wissenschaft bei der L��sung des Antibiotika-Problems nicht aus dem Blick geraten d��rfen. Es geht im Wesentlichen um zwei Aspekte: die in vielen L��ndern zunehmende Resistenz von bakteriellen Infektionserregern gegen die verf��gbaren Antibiotika und das Problem fehlender neuer Antibiotika., Diskussion, vol. 12, 2017

Published
2017
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109. Repaglinide versus insulin for newly diagnosed diabetes in patients with cystic fibrosis: a multicentre, open-label, randomised trial

Author

Ballmann, Manfred, primary, Hubert, Dominique, additional, Assael, Baroukh M, additional, Staab, Doris, additional, Hebestreit, Alexandra, additional, Naehrlich, Lutz, additional, Nickolay, Tanja, additional, Prinz, Nicole, additional, Holl, Reinhard W, additional, Staden, Ute, additional, Claßen, Martin, additional, Schuster, Antje, additional, Mellies, Uwe, additional, Posselt, Hans-Georg, additional, Wiebel, Matthias, additional, Rietschel, Ernst, additional, Stern, Martin, additional, Teschler, Helmut, additional, Smaczny, Christina, additional, Köhnlein, Thomas, additional, Wienhausen-Wilke, Vera, additional, Claaß, Andreas, additional, Biedermann, Thomas, additional, Dockter, Gerd, additional, Köster, Holger, additional, Hebestreit, Helge, additional, Ballke, Ernst-Hinrich, additional, Heuer, Hans-Eberhard, additional, Kamin, Wolfgang, additional, Küster, Peter, additional, Szczepanski, Rüdiger, additional, Keller, Klaus-Michael, additional, Generlich, Horst, additional, Bresser, Hans-Georg, additional, Kopp, Matthias, additional, Herting, Egbert, additional, Feickert, Hans-Joachim, additional, Hautz, Jürgen, additional, Schilling, Birgit, additional, Meyer, Egbert, additional, Mall, Marcus A, additional, Wiebicke, Wolfram, additional, Tegtmeyer, Friedrich-Karl, additional, Honer, Marguerite, additional, Mosnier-Pudar, Helen, additional, Lenoir, Gérard, additional, Robert, Jean-Jacques, additional, Kessler, Laurence, additional, Weiss, Laurence, additional, Nove-Josserand, Raphaële, additional, Vantyghem, Marie-Christine, additional, Munck, Anne, additional, Wizla, Nathalie, additional, Leroy, Sylvie, additional, Loeuille, Guy-André, additional, Serreau, Raphaël, additional, Aissat, Fawzia, additional, Thalhammer, Gabriela H, additional, Huttegger, Isidor, additional, Eichler, Irmgard, additional, and Götz, Manfred, additional

Published
2018
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113. Meta-analysis identifies seven susceptibility loci involved in the atopic march

Author

Marenholz, Ingo, Esparza-Gordillo, Jorge, Rüschendorf, Franz, Bauerfeind, Anja, Strachan, David P., Spycher, Ben D., Baurecht, Hansjörg, Margaritte-Jeannin, Patricia, Sääf, Annika, Kerkhof, Marjan, Ege, Markus, Baltic, Svetlana, Matheson, Melanie C., Li, Jin, Michel, Sven, Ang, Wei Q., McArdle, Wendy, Arnold, Andreas, Homuth, Georg, Demenais, Florence, Bouzigon, Emmanuelle, Söderhäll, Cilla, Pershagen, Göran, de Jongste, Johan C., Postma, Dirkje S., Braun-Fahrländer, Charlotte, Horak, Elisabeth, Ogorodova, Ludmila M., Puzyrev, Valery P., Bragina, Elena Yu, Hudson, Thomas J., Morin, Charles, Duffy, David L., Marks, Guy B., Robertson, Colin F., Montgomery, Grant W., Musk, Bill, Thompson, Philip J., Martin, Nicholas G., James, Alan, Sleiman, Patrick, Toskala, Elina, Rodriguez, Elke, Fölster-Holst, Regina, Franke, Andre, Lieb, Wolfgang, Gieger, Christian, Heinzmann, Andrea, Rietschel, Ernst, Keil, Thomas, Cichon, Sven, Nöthen, Markus M., Pennell, Craig E., Sly, Peter D., Schmidt, Carsten O., Matanovic, Anja, Schneider, Valentin, Heinig, Matthias, Hübner, Norbert, Holt, Patrick G., Lau, Susanne, Kabesch, Michael, Weidinger, Stefan, Hakonarson, Hakon, Ferreira, Manuel A. R., Laprise, Catherine, Freidin, Maxim B., Genuneit, Jon, Koppelman, Gerard H., Melén, Erik, Dizier, Marie- Hélène, Henderson, A John, Lee, Young Ae, Gastroenterology & Hepatology, Pediatrics, Erasmus MC other, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
HAY-FEVER, Male, Kinesins, Filaggrin Proteins, FOOD ALLERGY, FILAGGRIN MUTATIONS, immune system diseases, Child, RISK, BIRTH COHORT, Nuclear Proteins, Middle Aged, Neoplasm Proteins, DNA-Binding Proteins, Phenotype, Child, Preschool, Disease Progression, Female, ddc:500, Adult, Adolescent, Genotype, Nerve Tissue Proteins, 610 Medicine & health, Polymorphism, Single Nucleotide, Article, Dermatitis, Atopic, Ikaros Transcription Factor, Young Adult, 360 Social problems & social services, Humans, Genetic Predisposition to Disease, JUVENILE MYOCLONIC EPILEPSY, ddc:610, Receptor, Fibroblast Growth Factor, Type 1, CHROMOSOME 11Q13, Calcium-Binding Proteins, CHILDHOOD ASTHMA, Membrane Proteins, Asthma, Repressor Proteins, DERMATITIS, Adaptor Proteins, Vesicular Transport, Amino Acid Transport Systems, Neutral, Logistic Models, Cardiovascular and Metabolic Diseases, GENOMEWIDE ASSOCIATION, Interleukin-4, Carrier Proteins, Genome-Wide Association Study, Transcription Factors
Abstract

Eczema often precedes the development of asthma in a disease course called the ‘atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10−8) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10−9). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema., The development of asthma following eczema is known as the atopic march. Here the authors conduct a GWAS on affected children and identify two novel loci associated with the disease phenotype.

Published
2015

115. Lung clearance index in alpha-1-antitrypsin deficiency - A follow up

Author

Fuchs, Susanne, primary, Griese, Matthias, additional, Staab, Doris, additional, Pittschieler, Klaus, additional, Ahrens, Frank, additional, Rietschel, Ernst, additional, Schwerk, Nicolaus, additional, Gleiber, Wolfgang, additional, Baden, Winfried, additional, Köhnlein, Thomas, additional, Bals, Robert, additional, and Gappa, Monika, additional

Published
2016
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117. Enhancing actions of peptides derived from the γ-chain of fetal human hemoglobin on the immunostimulant activities of monophosphoryl lipid A

Author

Ulmer, Artur J, primary, Kaconis, Yani, additional, Heinbockel, Lena, additional, Correa, Wilmar, additional, Alexander, Christian, additional, Rietschel, Ernst Th, additional, Mach, Jean-Pierre, additional, Gorczynski, Reginald M, additional, Heini, Adrian, additional, Rössle, Manfred, additional, Richter, Walter, additional, Gutsmann, Thomas, additional, and Brandenburg, Klaus, additional

Published
2016
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125. Aut-idem für Adrenalin-Autoinjektoren?

Author

Klimek, Ludger, primary, Beyer, Kirsten, additional, Biedermann, Tilo, additional, Brockow, Knut, additional, Fischer, J., additional, Jung, Kirsten, additional, von Kopp, Matthias, additional, Lange, Lars, additional, Niggemann, Bodo, additional, Rietschel, Ernst, additional, Ring, Johannes, additional, and Worm, Margitta, additional

Published
2015
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128. Changing the Mindset in Life Sciences Toward Translation: A Consensus

Author

Duda, Georg N., primary, Grainger, David W., additional, Frisk, Megan L., additional, Bruckner-Tuderman, Leena, additional, Carr, Andrew, additional, Dirnagl, Ulrich, additional, Einhäupl, Karl Max, additional, Gottschalk, Stephen, additional, Gruskin, Elliott, additional, Huber, Christoph, additional, June, Carl H., additional, Mooney, David J., additional, Rietschel, Ernst Th., additional, Schütte, Georg, additional, Seeger, Werner, additional, Stevens, Molly M., additional, Urban, Robert, additional, Veldman, Alex, additional, Wess, Günther, additional, and Volk, Hans-Dieter, additional

Published
2014
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136. Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial

Author

Kerem, Eitan, primary, Konstan, Michael W, additional, De Boeck, Kris, additional, Accurso, Frank J, additional, Sermet-Gaudelus, Isabelle, additional, Wilschanski, Michael, additional, Elborn, J Stuart, additional, Melotti, Paola, additional, Bronsveld, Inez, additional, Fajac, Isabelle, additional, Malfroot, Anne, additional, Rosenbluth, Daniel B, additional, Walker, Patricia A, additional, McColley, Susanna A, additional, Knoop, Christiane, additional, Quattrucci, Serena, additional, Rietschel, Ernst, additional, Zeitlin, Pamela L, additional, Barth, Jay, additional, Elfring, Gary L, additional, Welch, Ellen M, additional, Branstrom, Arthur, additional, Spiegel, Robert J, additional, Peltz, Stuart W, additional, Ajayi, Temitayo, additional, and Rowe, Steven M, additional

Published
2014
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137. A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial

Author

Boyle, Michael P, primary, Bell, Scott C, additional, Konstan, Michael W, additional, McColley, Susanna A, additional, Rowe, Steven M, additional, Rietschel, Ernst, additional, Huang, Xiaohong, additional, Waltz, David, additional, Patel, Naimish R, additional, and Rodman, David, additional

Published
2014
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138. Triggers and Treatment of Anaphylaxis

Author

Worm, Margitta, primary, Eckermann, Oliver, additional, Dölle, Sabine, additional, Aberer, Werner, additional, Beyer, Kirsten, additional, Hawranek, Thomas, additional, Hompes, Stephanie, additional, Koehli, Alice, additional, Mahler, Vera, additional, Nemat, Katja, additional, Niggemann, Bodo, additional, Pföhler, Claudia, additional, Rabe, Uta, additional, Reissig, Angelika, additional, Rietschel, Ernst, additional, Scherer, Kathrin, additional, Treudler, Regina, additional, and Ruëff, Franziska, additional

Published
2014
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139. Leitlinie zu Akuttherapie und Management der Anaphylaxie

Author

Ring, Johannes, primary, Beyer, Kirsten, additional, Biedermann, Tilo, additional, Bircher, Andreas, additional, Duda, Dorothea, additional, Fischer, Jörg, additional, Friedrichs, Frank, additional, Fuchs, Thomas, additional, Gieler, Uwe, additional, Jakob, Thilo, additional, Klimek, Ludger, additional, Lange, Lars, additional, Merk, Hans F., additional, Niggemann, Bodo, additional, Pfaar, Oliver, additional, Przybilla, Bernhard, additional, Ruëff, Franziska, additional, Rietschel, Ernst, additional, Schnadt, Sabine, additional, Seifert, Roland, additional, Sitter, Helmut, additional, Varga, Eva-Maria, additional, Worm, Margitta, additional, and Brockow, Knut, additional

Published
2014
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140. Biological activities of lipopolysaccharides are determined by the shape of their lipid a portion

Author

Schromm, Andra B., Brandenburg, Klaus, Loppnow, Harald, Moran, Anthony P., Koch, Michel H. J., Rietschel, Ernst TH., and Seydel, Ulrich

Subjects
phospholipid-membranes, lps, receptor, human monocytes, antagonism, bacterial-endotoxin, macrophages, x-ray diffraction, agonism, binding-protein, molecular shape, lipids (amino acids, peptides, and proteins), molecules, recognition, lipid a, induction
Abstract

Lipopolysaccharide (LPS) represents a major virulence factor of Gram-negative bacteria ('endotoxin') that can cause septic shock in mammals including man. The lipid anchor of LPS to the outer membrane, lipid A, has a peculiar chemical structure, harbours the 'endotoxic principle' of LPS and is responsible for the expression of pathophysiological effects. Chemically modified lipid A can be endotoxically inactive, but may express strong antagonistic activity against LPS, a property that can be utilized in antisepsis treatment. We show here that these different biological activities are directly correlated with the molecular shape of lipid A. Only (hexaacyl) lipid A with a conical/concave shape, the cross-section of the hydrophobic region being larger than that of the hydrophilic region, exhibited strong interleukin-6 (IL-6)-inducing capacity. Most strikingly, a correlation between a cylindrical molecular shape of lipid A and antagonistic activity was established: IL-6 induction by enterobacterial LPS was inhibited by cylindrically shaped lipid A except for compounds with reduced headgroup charge. The antagonistic action is interpreted by assuming that lipid A molecules intercalate into the cytoplasmic membrane of mononuclear cells, and subsequently blocking of the putative signaling protein by the lipid A with cylindrical shape.

Published
2000

141. DifferentFCER1Apolymorphisms influence IgE levels in asthmatics and non-asthmatics

Author

Potaczek, Daniel P., primary, Michel, Sven, additional, Sharma, Vishwas, additional, Zeilinger, Sonja, additional, Vogelberg, Christian, additional, von Berg, Andrea, additional, Bufe, Albrecht, additional, Heinzmann, Andrea, additional, Laub, Otto, additional, Rietschel, Ernst, additional, Simma, Burkhard, additional, Frischer, Thomas, additional, Genuneit, Jon, additional, Illig, Thomas, additional, and Kabesch, Michael, additional

Published
2013
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143. Feasibility and Variability of Measuring the Lung Clearance Index in a Multi-Center Setting

Author

Fuchs, Susanne I., primary, Ellemunter, Helmut, additional, Eder, Johannes, additional, Mellies, Uwe, additional, Grosse-Onnebrink, Jörg, additional, Tümmler, Burkhard, additional, Staab, Doris, additional, Jobst, Andrea, additional, Griese, Matthias, additional, Ripper, Jan, additional, Rietschel, Ernst, additional, Zeidler, Susanne, additional, Ahrens, Frank, additional, and Gappa, Monika, additional

Published
2011
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144. Unifying Candidate Gene and GWAS Approaches in Asthma

Author

Michel, Sven, primary, Liang, Liming, additional, Depner, Martin, additional, Klopp, Norman, additional, Ruether, Andreas, additional, Kumar, Ashish, additional, Schedel, Michaela, additional, Vogelberg, Christian, additional, von Mutius, Erika, additional, von Berg, Andrea, additional, Bufe, Albrecht, additional, Rietschel, Ernst, additional, Heinzmann, Andrea, additional, Laub, Otto, additional, Simma, Burkhard, additional, Frischer, Thomas, additional, Genuneit, Jon, additional, Gut, Ivo G., additional, Schreiber, Stefan, additional, Lathrop, Mark, additional, Illig, Thomas, additional, and Kabesch, Michael, additional

Published
2010
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145. Nahrungsmittelanaphylaxie: Daten aus dem Anaphylaxie-Register

Author

Hompes, Stephanie, primary, Scherer, Karin, additional, Köhli, Alice, additional, Ruëff, Franziska, additional, Mahler, Vera, additional, Lange, Lars, additional, Treudler, Regina, additional, Rietschel, Ernst, additional, Szépfalusi, Zsolt, additional, Lang, Roland, additional, Rabe, Ute, additional, Reese, Thomas, additional, Beyer, Kirsten, additional, Schwerk, Nicolaus, additional, and Worm, Margitta, additional

Published
2010
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147. S3-Leitlinie Allergieprävention — Update 2009

Author

Muche-Borowski, Cathleen, primary, Kopp, Matthias, additional, Reese, Imke, additional, Sitter, Helmut, additional, Werfel, Thomas, additional, Schäfer, Torsten, additional, Beyer, Kirsten, additional, Friedrichs, Frank, additional, Hamelmann, Eckard, additional, Hellermann, Mechthild, additional, Huss-Marp, Johannes, additional, Kleinheinz, Andreas, additional, Lau, Susanne, additional, Rietschel, Ernst, additional, Rudack, Claudia, additional, Schmidt, Sabine, additional, Schnadt, Sabine, additional, and Schnitzer, Sylvia, additional

Published
2009
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150. Hemoglobin Enhances the Biological Activity of Synthetic and Natural Bacterial (Endotoxic) Virulence Factors: A General Principle

Author

Howe, Jorg, primary, Richter, Walter, additional, Hawkins, Lynn, additional, Rossle, Manfred, additional, Alexander, Christian, additional, Fournier, Karin, additional, Mach, Jean, additional, Waelli, Thierry, additional, Gorczynski, Reginald, additional, Ulmer, Artur, additional, Brade, Helmut, additional, Zamyatina, Alla, additional, Kosma, Paul, additional, Rietschel, Ernst Th., additional, and Brandenburg, Klaus, additional

Published
2008
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