Search

Your search keyword '"Rasul, Azhar"' showing total 612 results
Start Over Author "Rasul, Azhar"
612 results on '"Rasul, Azhar"'

102. Cross-Talk between Obesity and Diabetes: Introducing Polyphenols as an Effective Phytomedicine to Combat the Dual Sword Diabesity

Author

Shah, Muhammad Ajmal, primary, Haris, Muhammad, additional, Faheem, Hafiza Ishmal, additional, Hamid, Ayesha, additional, Yousaf, Rimsha, additional, Rasul, Azhar, additional, Shah, Ghulam Mujtaba, additional, Khalil, Atif Ali Khan, additional, Wahab, Abdul, additional, Khan, Haroon, additional, Alhasani, Reem Hasaballah, additional, and Althobaiti, Norah A., additional

Published
2022
Full Text
View/download PDF

112. Enhanced Solubility and Biological Activity of Dexibuprofen-Loaded Silica-Based Ternary Solid Dispersions.

Author

Asim, Muhammad, Nazir, Marriam, Chauhdary, Zunera, Irfan, Muhammad, Khalid, Syed Haroon, Asghar, Sajid, Usra, Felimban, Raed I., Majrashi, Mohammed A, Hazzazi, Mohannad S., Alissa, Mohammed, Qahl, Safa H, Hussain, Ghulam, Rasul, Azhar, Chatha, Shahzad Ali Shahid, and Khan, Ikram Ullah

Subjects
SOLUBILITY, DISPERSION (Chemistry), ANTI-inflammatory agents, DRUG solubility
Abstract

The current study was designed to formulate ternary solid dispersions (TSDs) of dexibuprofen (Dex) by solvent evaporation to augment the solubility and dissolution profile, in turn providing gastric protection and effective anti-inflammatory activity. Initially, nine formulations (S1 to S9) of binary solid dispersions (BSDs) were developed. Formulation S1 comprising a 1:1 weight ratio of Dex and Syloid 244FP® was chosen as the optimum BSD formulation due to its better solubility profile. Afterward, 20 TSD formulations were developed using the optimum BSD. The formulation containing Syloid 244FP® with 40% Gelucire 48/16® (S18) and Poloxamer 188® (S23) successfully enhanced the solubility by 28.23 and 38.02 times, respectively, in pH 6.8, while dissolution was increased by 1.99- and 2.01-fold during the first 5 min as compared to pure drug. The in vivo gastroprotective study in rats suggested that the average gastric lesion index was in the order of pure Dex (8.33 ± 2.02) > S1 (7 ± 1.32) > S18 (2.17 ± 1.61) > S23 (1.83 ± 1.04) > control (0). The in vivo anti-inflammatory study in rats revealed that the percentage inhibition of swelling was in the order of S23 (71.47 ± 2.16) > S18 (64.8 ± 3.79) > S1 (54.14 ± 6.78) > pure drug (18.43 ± 2.21) > control (1.18 ± 0.64) after 6 h. ELISA results further confirmed the anti-inflammatory potential of the developed formulation, where low levels of IL-6 and TNF alpha were reported for animals treated with S23. Therefore, S23 could be considered an effective formulation that not only enhanced the solubility and bioavailability but also reduced the gastric irritation of Dex. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

113. Identification of Lignan Compounds as New 6-Phosphogluconate Dehydrogenase Inhibitors for Lung Cancer.

Author

Khan, Gul Bushra, Qasim, Muhammad, Rasul, Azhar, Ashfaq, Usman Ali, and Alnuqaydan, Abdullah M.

Subjects
LUNG cancer, PENTOSE phosphate pathway, CANCER cells, DRUG discovery, MOLECULAR dynamics, BINDING sites, NEOLIGNANS, LIGNANS
Abstract

Targeting pentose phosphate pathway (PPP) enzymes has emerged as a promising strategy to combat cancer. 6-Phosphogluconate dehydrogenase (6-PGD), the third critical enzyme of the PPP, catalyzes oxidative decarboxylation of 6-phosphogluconate (6-PG) to produce ribulose-5-phosphate (Ru-5-P) and CO2. Overexpression of 6-PGD has been reported in multiple cancers and is recognized as a potential anticancer drug target. The current study is focused on the utilization of indispensable virtual screening tools for structure-based drug discovery. During the study, 17,000 natural compounds were screened against the 3-phosphoglycerate (3-PG) binding site of 6-PGD through a molecular operating environment (MOE), which revealed 115 inhibitors with higher selectivity and binding affinity. Out of the 115 best-fit compounds within the 6-PGD binding cavity, 15 compounds were selected and optimized through stringent in silico ADMET assessment models that justified the desirable pharmacokinetic, pharmacodynamic and physicochemical profiles of 5 ligands. Further protein–ligand stability assessment through molecular dynamics (MD) simulation illustrated three potential hits, secoisolariciresinol, syringaresinol and cleomiscosin A, with stable confirmation. Moreover, 6-PGD inhibitor validation was performed by an in vitro enzymatic assay using human erythrocytes purified 6-PGD protein and A549 cell lysate protein. The results of the in vitro assays supported the in silico findings. In order to gain insight into the anticancer activity of the aforementioned compounds, they were subjected to CLC-Pred, an in silico cytotoxicity browsing tool, which proved their anticancer activity against several cancer cell lines at Pa > 0.5. Additionally, a confirmation for in silico cytotoxicity was made by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for commercially available hits syringaresinol and cleomiscosin A against lung cancer (A549) cells. The results demonstrated that syringaresinol has an IC50 value of 36.9 μg/mL, while cleomiscosin A has an IC50 value of 133 μg/mL. After MTT, flow cytometry analysis confirmed that compounds induced apoptosis in A549 cells in a dose-dependent manner. This study suggested that the respective lignan compounds can serve as lead candidates for lung cancer therapy via 6-PGD inhibition. Furthermore, in vivo experiments need to be conducted to confirm their efficacy. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

115. Dietary biomolecules as promising regenerative agents for peripheral nerve injury: An emerging nutraceutical‐based therapeutic approach

Author

Anwar, Haseeb, primary, Rasul, Azhar, additional, Iqbal, Javed, additional, Ahmad, Nazir, additional, Imran, Ali, additional, Malik, Shoaib Ahmad, additional, Ijaz, Fazeela, additional, Akram, Rabia, additional, Maqbool, Javeria, additional, Sajid, Faiqa, additional, Sun, Tao, additional, Hussain, Ghulam, additional, and Manzoor, Muhammad Faisal, additional

Published
2021
Full Text
View/download PDF

126. Calotropis procera(leaves) supplementation exerts curative effects on promoting functional recovery in a mouse model of peripheral nerve injury

Author

Zafar, Shamaila, primary, Rasul, Azhar, additional, Iqbal, Javed, additional, Anwar, Haseeb, additional, Imran, Ali, additional, Jabeen, Farhat, additional, Shabbir, Asghar, additional, Akram, Rabia, additional, Maqbool, Javeria, additional, Sajid, Faiqa, additional, Arshad, Muhammad Umair, additional, Hussain, Ghulam, additional, and Islam, Saiful, additional

Published
2021
Full Text
View/download PDF

127. sj-pdf-1-tih-10.1177_07482337211034711 – Supplemental Material for Nickel nanoparticles induce hepatotoxicity via oxidative and nitrative stress-mediated apoptosis and inflammation

Author

Iqbal, Shabnoor, Jabeen, Farhat, Peng, Cheng, Shah, Muhammad Ajmal, Ijaz, Muhammad Umar, Rasul, Azhar, Ali, Shujat, Rauf, Abdur, Batiha, Gaber ES, and Kłodzińska, Ewa

Subjects
FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, sj-pdf-1-tih-10.1177_07482337211034711 for Nickel nanoparticles induce hepatotoxicity via oxidative and nitrative stress-mediated apoptosis and inflammation by Shabnoor Iqbal, Farhat Jabeen, Cheng Peng, Muhammad Ajmal Shah, Muhammad Umar Ijaz, Azhar Rasul, Shujat Ali, Abdur Rauf, Gaber ES Batiha and Ewa Kłodzińska in Toxicology and Industrial Health

Published
2021
Full Text
View/download PDF

129. Maternotoxicity and fetotoxicity in Rattus norvegicus albinus exposed to tramadol during the late phase of pregnancy

Author

Akhtar, Muhammad Furqan, Younas, Sobia, Saleem, Ammara, Baig, Mirza Muhammad Faran Ashraf, Sharif, Ali, Abdel-Daim, Mohamed M., Rasul, Azhar, Saleem, Mohammad, Akhtar, Muhammad Furqan, Younas, Sobia, Saleem, Ammara, Baig, Mirza Muhammad Faran Ashraf, Sharif, Ali, Abdel-Daim, Mohamed M., Rasul, Azhar, and Saleem, Mohammad

Abstract

Objectives: Tramadol, an atypical opioid, is clinically efficacious in treating moderate to severe pain. The aim of current study was to find out the toxicological effects of tramadol exposure to pregnant rats and fetuses during the late phase of pregnancy. Methods: Wistar pregnant rats were exposed to 1.25, 2.5, or 5 mg/kg/day tramadol from 14th to 20th day of pregnancy. The same therapy was given to nonpregnant rats for 7 days. The body weight, oral glucose and lipid tolerance tests, and effect on complete blood parameters in both pregnant and nonpregnant rats were determined. On 20th day, maternal placentas were excised and weighed while fetuses were observed for any deformity and growth retardation. Oxidative stress biomarkers were estimated in the liver and kidney tissue homogenates of the pregnant and nonpregnant rats while the whole fetus homogenate was processed for the same. Moreover, histopathology of the liver and kidney of pregnant and nonpregnant rats were carried out. Results: Tramadol administration did not significantly alter the area under curve of the blood glucose and triglyceride levels in both the pregnant and nonpregnant rats. It reduced the live fetuses, placental weights, fetal length, and fetal weights. Tramadol treated pregnant rats showed significantly (p <.05) reduced red blood cells, hematocrit, hemoglobin, and platelets with reference to control group. Similarly, structural abnormalities and malfunctioning of the liver and kidney of pregnant rats were instituted; however, it did not affect the structural integrity of nonpregnant rats. A substantial (p <.001–.0001) altered glutathione and malondialdehyde levels in the fetuses, pregnant, and nonpregnant animals (tissue homogenates) at all dosage levels were indicative of tramadol induced oxidative stress. Furthermore, tramadol exposure resulted in more significant (p <.01–.001) alteration of lipid profile in the pregnant than the nonpregnant animals. Conclusion: Acquired results suggested

Published
2021

135. House Fly, Musca domestica (Diptera: Muscidae) Acts as a Mechanical Vector for Newcastle Disease of Poultry in Faisalabad, Pakistan.

Author

Fayyaz, Aqsa, Zahoor, Muhammad Kashif, Ashraf, Asma, Zahoor, Muhammad Asif, Rasul, Azhar, Majeed, Humara Naz, Zulhussnain, Muhammad, Ranian, Kanwal, Riaz, Bushra, Khalil, Nazia, and Attaullah

Abstract

Newcastle disease virus (NDV) is a highly contagious virus of domesticated (i.e. chickens, peacock, pet birds) and wild birds, which is excreted in the fecal material of infected birds. The house fly, Musca domestica L. can gain entry into the poultry flocks and will feed on poultry droppings and potentially serves as a mechanical vector for Newcastle disease. During the current study, houseflies were captured and examined for the presence of NDV. A total of 80 samples were collected from eight different poultry farms located around Faisalabad city with ten samples from each farm viz. Khurrianwala road, Shahkot road, Faisalabad road, Satyana road, Jhumra road, Nankana sahib road, Lahore road and Jaranwala road. Homogenate from house flies was first harvested in 11 day old embryonated chicken eggs to propagate the NDV, which was then titrated using haemagglutination inhibition assay for quantification of NDV. Polyclonal antibodies were produced in experimental rabbits followed by titration. These antibodies were then used to detect the presence of NDV. Sixteen samples were found positive (20%), 62 negative (77.5 %) and two unreactive (2.5 %) for NDV. All of the poultry farms around Faisalabad showed positive NDV (ranging from 1 to 4 samples). We conclud that house flies can play a role in the mechanical transmission of ND virus. Moreover, it is also suggested that positive poultry farms are likely to cause NDV infection to other farms in the vicinity due to the house fly flight range. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

137. Physcion and Physcion 8-O-β-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities

Author

Adnan, Muhammad, primary, Rasul, Azhar, additional, Hussain, Ghulam, additional, Shah, Muhammad Ajmal, additional, Sarfraz, Iqra, additional, Nageen, Bushra, additional, Riaz, Ammara, additional, Khalid, Rida, additional, Asrar, Muhammad, additional, Selamoglu, Zeliha, additional, Adem, Şevki, additional, and Sarker, Satyajit D., additional

Published
2021
Full Text
View/download PDF

138. Chemical characterisation, in vitro antioxidant, cytotoxicity and safety evaluation of Polystichum braunii (Spenn.) fee roots

Author

Saleem, Ammara, Saleem, Mohammad, Akhtar, Muhammad Furqan, Rasul, Azhar, and Baig, Mirza Muhammad Faran Ashraf

Abstract

The study was intended to find in vitro antioxidant, cytotoxicity and safety profile of Polystichum braunii roots extracts and chemically characterise it by GC–MS and FTIR spectroscopy. Acute and sub-chronic (90-day oral repeated dose at 150, 300 and 600 mg/kg) toxicity studies of P. braunii methanol extract (PBME) were performed in Wistar rats by adopting OECD guidelines. The PBME exerted the highest in vitro antioxidant potential. There was no substantial change in blood parameters and body weight except a notable (p < 0.01) rise in ALT, ALP, MDA and HDL, and decrease in cholesterol and LDL (p < 0.05) in animals sub-chronically treated with PBME at 600 mg/kg dose. The IC50 in HepG2 was more than 1000 µg/ml. The GC–MS analysis revealed Pentadecanoic acid and 9,12-Octadecadienoic acid in PBME. The P. braunii might be safe in acute usage, however, monitoring of liver function tests should be carried out during long-term use.

Published
2020
Full Text
View/download PDF

141. Phytochemical and Molecular Dynamic Analysis of Novel Biomolecule Lancifotarene Extracted From Conocarpus Lancifolius as Cytotoxic, Antiurease and Antidiabetic Agent

Author

Saadullah, Malik, primary, Asif, Muhammad, additional, Bibi, Shabana, additional, Shah, Muhammad Ajmal, additional, Chohan, Tahir Ali, additional, Rasul, Azhar, additional, Uzair, Muhammad, additional, Alqarni, Mohammed, additional, Elazab, Sara T., additional, and El-saber, Gaber, additional

Published
2021
Full Text
View/download PDF

145. Radioprotective Role of Natural Polyphenols: From Sources to Mechanisms

Author

Hussain, Syed M., primary, Adnan, Muhammad, additional, Rasul, Azhar, additional, Shah, Muhammad A., additional, Hussain, Ghulam, additional, Asrar, Muhammad, additional, Riaz, Ammara, additional, Sarfraz, Iqra, additional, Hussain, Arif, additional, Khorsandi, Khatereh, additional, and Lai, Ngit S., additional

Published
2021
Full Text
View/download PDF

146. The association between serum cortisol, thyroid profile, paraoxonase activity, arylesterase activity and anthropometric parameters of undergraduate students under examination stress

Author

Anjum, Armghan, primary, Anwar, Haseeb, additional, Sohail, Muhammad Umar, additional, Ali Shah, Syed Muhammad, additional, Hussain, Ghulam, additional, Rasul, Azhar, additional, Ijaz, Muhammad Umar, additional, Nisar, Jaweria, additional, Munir, Naveed, additional, and Shahzad, Asif, additional

Published
2021
Full Text
View/download PDF

147. Potential role of probiotic species in ameliorating oxidative stress, effect on liver profile and hormones in male albino rat model

Author

Anwar, Haseeb, primary, Hussain, Ghulam, additional, Rasul, Azhar, additional, Ali Shah, Syed Muhammad, additional, Naqvi, Syed Ali Raza, additional, Bukhari, Shazia Anwer, additional, Sohail, Muhammad Umar, additional, Faisal, Muhammad Naeem, additional, Mustafa, Imtiaz, additional, Munir, Naveed, additional, Nisar, Jaweria, additional, Shaukat, Arslaan, additional, and Muzaffer, Humaira, additional

Published
2021
Full Text
View/download PDF

149. Effect of Nano-Se Particles Supplemented Sunflower Meal Based Diets on Mineral Absorption and Carcass Composition of Cirrhinus mrigala Fingerlings.

Author

Ahmad, Nisar, Hussain, Syed Makhdoom, Rasul, Azhar, Shahzad, M. Mudassar, Javid, Arshad, Azmat, Hamda, Arsalan, M. Zubair ul Hassan, Tabassum, Sadia, and Ahmad, Bilal

Abstract

The research was conducted to estimate the efficacy of Se nanoparticles on mineral absorption and carcass composition of C. mrigala fingerlings fed nano-Se particles supplemented sunflower meal based diets. The experiment was consisted on seven test diets on the basis of supplementation of nano Se graded levels (0, 0.5, 1, 1.5, 2, 2.5 and 3 mg/kg). Chromic oxide was added as an inert marker. Fingerlings were fed at the rate of 5% of their live wet weight. Maximum improvement in mineral absorption (Ca, Na, K, Cu, P and Al) was observed at test diet with 1.5 mg/kg supplementation of Se nanoparticles. Maximum Fe, Mn and Cr absorption was noted at 2 mg/kg supplementation of nano Se. The highest absorption of Mg and Zn was found in the fingerlings fed at test diet with 1 mg/kg supplementation of nano Se particles. The best results in regard of body composition (CP; 61% and EE; 14%) were noted in fingerlings when fed 1.5 mg/kg levels of Se-nano particles based diets. It was concluded from the results of current study that supplementation of Se NPs (1.5 mg/kg) in sunflower meal based diet improves the mineral absorption and body composition of C. mrigala fingerlings. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

150. Contributors

Author

Abbasi-Kolli, Mohammad, Abdullah, Ahmad, Saeed, Ahmed, Imad, Akhtar, Muhammad Furqan, Al-Ghamdi, Mariam S., Al-Harrasi, Ahmed, Alam, Waqas, Ali, Arif, Ali, Gowhar, Ali, Mubarika, Alothaim, Abdul Aziz S., Althobaiti, Nora A., Aly, Shaza H., Aman, Waqar, Asif, Muhammad, Azhdari, Sara, Bayat, Mobina, Blundell, Renald, Chauhdary, Zunera, Ebrahimi, Mohammad Saeid, Eldahshan, Omayma A., Fayed, Marwa A.A., Hosseini, Zohreh, Hussain, Yaseen, Islam, Waseem ul, Kabir, Md. Tanvir, Khan, Faizullah, Khan, Fazlullah, Khan, Haroon, Khatami, Alireza, Khayami, Reza, Kouchaki, Ebrahim, Mahjoubin-Tehran, Maryam, Malik, Abd, Martins, Alice Maria Costa, Mirzaei, Hamed, Modiri, Navid, Moghoofei, Mohsen, Morshedi, Korosh, Mostafa, Nada M., Naveed, Aamir, Qasim, Muhammad, Rahman, Md. Habibur, Rahman, Shaikh Mizanoor, Rashad, Muhammad, Rasul, Azhar, Refaey, Mohamed S., Rezaei, Samaneh, Saadullah, Malik, Sadri Nahand, Javid, Saleem, Ammara, Saleem, Mohammad, Saleem, Uzma, Salmaninejad, Arash, Samadi-khouzani, Abbas, Shafabakhsh, Rana, Shah, Muhammad Ajmal, Siddique, Rida, Siddiqui, Muhammad Faisal, Taghizadieh, Mohammad, Taheri, Forough, ur Rehman, Maqsood, and Waqas, Muhammad

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results