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102. SP696SOLUBLE TLR4 IN HEMODIALYSIS PATIENTS

Author

Esposito, Pasquale, primary, La Porta, Edoardo, additional, Calatroni, Marta, additional, Grignano, Maria Antonietta, additional, Caramella, Elena, additional, Avella, Alessandro, additional, Milanesi, Samantha, additional, Verzola, Daniela, additional, Ansaldo, Francesca, additional, Battaglia, Yuri, additional, Gregorini, Marilena, additional, Libetta, Carmelo, additional, Garibotto, Giacomo, additional, and Rampino, Teresa, additional

Published
2017
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108. Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR

Author

Gregorini, Marilena, primary, Corradetti, Valeria, additional, Rocca, Chiara, additional, Pattonieri, Eleonora Francesca, additional, Valsania, Teresa, additional, Milanesi, Samantha, additional, Serpieri, Nicoletta, additional, Bedino, Giulia, additional, Esposito, Pasquale, additional, Libetta, Carmelo, additional, Avanzini, Maria Antonietta, additional, Mantelli, Melissa, additional, Ingo, Daniela, additional, Peressini, Sabrina, additional, Albertini, Riccardo, additional, Dal Canton, Antonio, additional, and Rampino, Teresa, additional

Published
2016
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109. Pielonefrite Cronica: una Causa Misconosciuta di Perdita del Trapianto di Rene

Author

Corradetti, Valeria, Pattonieri, Eleonora, Rocca, Chiara, Valsania, Teresa, Gregorini, Marilena, Rampino, Teresa, Martinelli, Claudia, Esposito, Pasquale, Dal Canton, Antonio, Corradetti, Valeria, Pattonieri, Eleonora, Rocca, Chiara, Valsania, Teresa, Gregorini, Marilena, Rampino, Teresa, Martinelli, Claudia, Esposito, Pasquale, and Dal Canton, Antonio

Abstract

non disponibile, No Abstract

Published
2015

110. Chronic Pyelonephritis: a Unknown Cause of Kidney Transplant Loss: questionnaire solutions

Author

Corradetti, Valeria, Pattonieri, Eleonora, Rocca, Chiara, Valsania, Teresa, Gregorini, Marilena, Rampino, Teresa, Martinelli, Claudia, Esposito, Pasquale, Dal Canton, Antonio, Corradetti, Valeria, Pattonieri, Eleonora, Rocca, Chiara, Valsania, Teresa, Gregorini, Marilena, Rampino, Teresa, Martinelli, Claudia, Esposito, Pasquale, and Dal Canton, Antonio

Abstract

No Abstract, non disponibile

Published
2015

111. Chronic Pyelonephritis: a Unknown Cause of Kidney Transplant Loss

Author

Corradetti, Valeria, Pattonieri, Eleonora, Rocca, Chiara, Valsania, Teresa, Gregorini, Marilena, Rampino, Teresa, Martinelli, Claudia, Esposito, Pasquale, Dal Canton, Antonio, Corradetti, Valeria, Pattonieri, Eleonora, Rocca, Chiara, Valsania, Teresa, Gregorini, Marilena, Rampino, Teresa, Martinelli, Claudia, Esposito, Pasquale, and Dal Canton, Antonio

Abstract

Chronic pyelonephritis: a misunderstood cause of renal allograft loss Although urinary tract infections (UTI) are the most frequent infections in kidney transplant patients, there are no sufficient data about the prevalence of acute and chronic pyelonephritis and organ or patient survival. We present the clinical case of a young woman with a kidney transplant admitted to our Nephrology Clinic because of an acute worsening of renal function and a history of recurrent UTI. The renal biopsy showed medullary tissue with a severe tubule-interstitial damage, suggestive for acute rejection, insomuch that steroids were prescribed. Due to the lack of any clinical improvement, a second biopsy was performed, showing a histological picture of chronic pyelonephritis with a severe and advanced damage. Subsequently, because of the severe renal failure the patient underwent peritoneal dialysis and transplant nephrectomy. This clinical case is exemplificative of the possible adverse outcomes of recurrent UTI that might lead in a short time to organ failure, highlighting the importance of a definitive histologic diagnosis., non disponibile

Published
2015

113. Sirolimus vs cyclosporine after induction with basiliximab does not promote regulatory T cell expansion in de novo kidney transplantation: Results from a single-center randomized trial

Author

Libetta, Carmelo, primary, Esposito, Pasquale, additional, Gregorini, Marilena, additional, Margiotta, Elisa, additional, Martinelli, Claudia, additional, Borettaz, Ilaria, additional, Canevari, Michele, additional, Rampino, Teresa, additional, Ticozzelli, Elena, additional, Abelli, Massimo, additional, Meloni, Federica, additional, and Dal Canton, Antonio, additional

Published
2015
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116. FP776EFFECTS OF DIALYSIS MODALITY ON MYOSTATIN/HGF BALANCE IN REGULAR HD PATIENTS

Author

Esposito, Pasquale, primary, La Porta, Edoardo, additional, Milanesi, Samantha, additional, Calatroni, Marta, additional, Martinelli, Claudia, additional, Borettaz, Ilaria, additional, Canevari, Michele, additional, Verzola, Daniela, additional, Rampino, Teresa, additional, Libetta, Carmelo, additional, Garibotto, Giacomo, additional, and Dal Canton, Antonio, additional

Published
2015
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117. SP770PRE-CONDITIONING OF RENAL GRAFT WITH MESENCHYMAL STROMAL CELLS PREVENTS ISCHEMIA DAMAGE UPREGULATING GENE INVOLVED IN ENERGY SAVING

Author

Rocca, Chiara, primary, Milanesi, Samantha, additional, Corradetti, Valeria, additional, Pattonieri, Eleonora Francesca, additional, Valsania, Teresa, additional, Gregorini, Marilena, additional, Dugo, Matteo, additional, De Cecco, Loris, additional, Benzoni, Ilaria, additional, Bianco, Carolina, additional, Avanzini, Maria Antonietta, additional, Mantelli, Melissa, additional, Ingo, Daniela, additional, Maestri, Marcello, additional, Cannone, Manuela, additional, Esposito, Pasquale, additional, Rampino, Teresa, additional, and Dal Canton, Antonio, additional

Published
2015
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119. Assessment of physical performance and quality of life in kidney-transplanted patients: a cross-sectional study.

Author

Esposito, Pasquale, Furini, Francesco, Rampino, Teresa, Gregorini, Marilena, Petrucci, Lucia, Klersy, Catherine, Dal Canton, Antonio, and Toffola, Elena Dalla

Subjects
KIDNEY transplantation, QUALITY of life, PHYSICAL fitness testing
Abstract

Background: Information on physical and mentalwellness in renal transplantation is limited. Therefore, we performed a crosssectional study to evaluate and describe the different components of physical performance and quality of life (QoL) in a cohort of kidney-transplanted patients. Methods: Physical performance and QoL were determined through the administration of validated tests and questionnaires [muscle strength, dynamometer handgrip, tactile sensitivity, visual analogue scale (VAS) for pain, Timed Up and Go (TUG) test, Fatigue Severity Scale (FSS) and the 36-item Short Form Health Survey]. The patients were divided into three groups based on time elapsed since transplantation: early (in the first 6 months), middle (from 7 to 60 months) and late (>60 months). Results: Of 132 enrolled patients, 11 patients (8.3%) presented a severe reduction of muscle strength, 63 patients (47%) had significant bilateral impaired handgrip and tactile sensitivity was altered in 23 patients (17.4%). TUG assessment showed significant mobility limitation in 29 patients (21.9%). The FSS presented a pathological value in 50 patients (37.3%), while the mean VAS was 1.8 ± 2.7. There were no significant differences in physical performance parameters among the three patient groups. There were inverse correlations among different components of physical performance and age, comorbidity and dialysis vintage, and therewas a direct correlation with renal function. During the first months after transplantation therewere limitations in physical, social and emotional activities. Overall, the self-perceived physical performancewas significantly lower in transplanted patients with respect to the normal reference level. Conclusion: Kidney-transplanted patientsmay present different degrees of impairment in physical performance and quality of life. Systematic functional assessment is essential to identify patients needing intensive and personalized rehabilitation programmes. [ABSTRACT FROM AUTHOR]

Published
2017
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121. Mesenchymal stromal cells reset the scatter factor system and cytokine network in experimental kidney transplantation

Author

Gregorini, Marilena, primary, Bosio, Francesca, additional, Rocca, Chiara, additional, Corradetti, Valeria, additional, Valsania, Teresa, additional, Pattonieri, Eleonora Francesca, additional, Esposito, Pasquale, additional, Bedino, Giulia, additional, Collesi, Chiara, additional, Libetta, Carmelo, additional, Frassoni, Francesco, additional, Canton, Antonio Dal, additional, and Rampino, Teresa, additional

Published
2014
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122. Trattamento del danno renale da iperbilirubinemia mediante plasma adsorbimento/perfusione

Author

Sileno, Giuseppe, Rampino, Teresa, Marchi, Gianluca, Scaramuzzi, Maria Luisa, Fasoli, Gianluca, Montagna, Francesca, Dal Canton, Antonio, Esposito, Pasquale, Sileno, Giuseppe, Rampino, Teresa, Marchi, Gianluca, Scaramuzzi, Maria Luisa, Fasoli, Gianluca, Montagna, Francesca, Dal Canton, Antonio, and Esposito, Pasquale

Abstract

Severe hyperbilirubinemia is often associated with acute kidney injury (AKT). Considering the potential renal toxicity of bilirubin, it is possible that bilirubin removal per se could represent a way to improve renal function in patients experiencing jaundice-related AKI. Here we present the case of a 47-year-old male patient, who was admitted due to severe jaundice and ascites. The patient presented a history of idiopathic myelofibrosis, associated with liver disease with stable bilirubin values of about 4 mg/dL. At admission, blood tests showed plasma bilirubin of 45 mg/dL, normal liver enzymes and AKI (creatinine 2.1 mg/dL vs a previous value of 0.7 mg/dL). Instrumental examinations and liver biopsy showed a picture of diffuse inflammatory cholangitis. During hospitalization, bilirubin levels further raised (up to 59.7 mg/dL) and, simultaneously, kidney function declined. We excluded functional causes of renal failure and hepatorenal syndrome and thus, suspecting a bilirubin-associated nephrotoxicity, we decided to treat the patient with plasma adsorption perfusion (PAP), a technique based on plasma adsorption by a bilirubin-specific adsorbent. After the treatment plasma bilirubin, as well as creatinine serum levels, progressively decreased. Unfortunately, about 10 days after the beginning of PAP the patient died of septic shock. This case represents an additional proof of the potential nephrotoxicity of bilirubin, suggesting that PAP could be a valuable therapeutic option in patients with jaundice-related AKI., L'iperbilirubinemia severa si associa spesso al danno renale acuto (AKI), soprattutto in pazienti con livelli di bilirubinemia pari a 20–25 mg/dL. Considerando la potenziale tossicità renale della bilirubina, è possibile che la rimozione di tale sostanza dal plasma rappresenti un modo per migliorare la funzione renale nei pazienti con AKI associato a iperbilirubinemia. Qui presentiamo il caso di un uomo di 47 anni, ricoverato per ittero ingravescente e ascite. All'anamnesi il paziente presentava una mielofibrosi idiopatica, associata a epatopatia con valori di bilirubina stabili intorno ai 4 mg/dL. Al momento del ricovero, la bilirubinemia era pari a 45 mg/dL, con valori di creatininemia di 2.1 mg (valore precedente 0.7 mg/dL). La biopsia epatica mostrava un quadro di severa colangite linfogranulocitaria. Per il peggioramento del quadro ematochimico (bilirubinemia 59.7 mg/dL e creatininemia 4 mg/dL), una volta escluse cause funzionali di insufficienza renale e la sindrome epato-renale, sospettando un danno renale da iperbilirubinemia, abbiamo iniziato il trattamento con plasma adsorbimento/perfusione (PAP). Tale metodica si basa sulla rimozione selettiva della bilirubina dal plasma mediante una specifica resina adsorbente. Dopo il trattamento, si assisteva a una riduzione dei livelli di bilirubina sierica fino a 24 mg/dL, associata a un significativo miglioramento della funzione renale. Tuttavia, circa dieci giorni dopo l'inizio della PAP, il paziente decedeva per shock settico. Questo caso rappresenta un'ulteriore prova della potenziale nefrotossicità della bilirubina, suggerendo che la PAP potrebbe essere una valida opzione terapeutica nei pazienti con danno renale acuto secondario a iperbilirubinemia.

Published
2013

123. Selective Bilirubin Removal as Treatment of Jaundice-Related Kidney Injury

Author

Sileno, Giuseppe, Rampino, Teresa, Marchi, Gianluca, Scaramuzzi, Maria Luisa, Fasoli, Gianluca, Montagna, Francesca, Dal Canton, Antonio, Esposito, Pasquale, Sileno, Giuseppe, Rampino, Teresa, Marchi, Gianluca, Scaramuzzi, Maria Luisa, Fasoli, Gianluca, Montagna, Francesca, Dal Canton, Antonio, and Esposito, Pasquale

Abstract

Severe hyperbilirubinemia is often associated with acute kidney injury (AKT). Considering the potential renal toxicity of bilirubin, it is possible that bilirubin removal per se could represent a way to improve renal function in patients experiencing jaundice-related AKI. Here we present the case of a 47-year-old male patient, who was admitted due to severe jaundice and ascites. The patient presented a history of idiopathic myelofibrosis, associated with liver disease with stable bilirubin values of about 4 mg/dL. At admission, blood tests showed plasma bilirubin of 45 mg/dL, normal liver enzymes and AKI (creatinine 2.1 mg/dL vs a previous value of 0.7 mg/dL). Instrumental examinations and liver biopsy showed a picture of diffuse inflammatory cholangitis. During hospitalization, bilirubin levels further raised (up to 59.7 mg/dL) and, simultaneously, kidney function declined. We excluded functional causes of renal failure and hepatorenal syndrome and thus, suspecting a bilirubin-associated nephrotoxicity, we decided to treat the patient with plasma adsorption perfusion (PAP), a technique based on plasma adsorption by a bilirubin-specific adsorbent. After the treatment plasma bilirubin, as well as creatinine serum levels, progressively decreased. Unfortunately, about 10 days after the beginning of PAP the patient died of septic shock. This case represents an additional proof of the potential nephrotoxicity of bilirubin, suggesting that PAP could be a valuable therapeutic option in patients with jaundice-related AKI., L'iperbilirubinemia severa si associa spesso al danno renale acuto (AKI), soprattutto in pazienti con livelli di bilirubinemia pari a 20–25 mg/dL. Considerando la potenziale tossicità renale della bilirubina, è possibile che la rimozione di tale sostanza dal plasma rappresenti un modo per migliorare la funzione renale nei pazienti con AKI associato a iperbilirubinemia. Qui presentiamo il caso di un uomo di 47 anni, ricoverato per ittero ingravescente e ascite. All'anamnesi il paziente presentava una mielofibrosi idiopatica, associata a epatopatia con valori di bilirubina stabili intorno ai 4 mg/dL. Al momento del ricovero, la bilirubinemia era pari a 45 mg/dL, con valori di creatininemia di 2.1 mg (valore precedente 0.7 mg/dL). La biopsia epatica mostrava un quadro di severa colangite linfogranulocitaria. Per il peggioramento del quadro ematochimico (bilirubinemia 59.7 mg/dL e creatininemia 4 mg/dL), una volta escluse cause funzionali di insufficienza renale e la sindrome epato-renale, sospettando un danno renale da iperbilirubinemia, abbiamo iniziato il trattamento con plasma adsorbimento/perfusione (PAP). Tale metodica si basa sulla rimozione selettiva della bilirubina dal plasma mediante una specifica resina adsorbente. Dopo il trattamento, si assisteva a una riduzione dei livelli di bilirubina sierica fino a 24 mg/dL, associata a un significativo miglioramento della funzione renale. Tuttavia, circa dieci giorni dopo l'inizio della PAP, il paziente decedeva per shock settico. Questo caso rappresenta un'ulteriore prova della potenziale nefrotossicità della bilirubina, suggerendo che la PAP potrebbe essere una valida opzione terapeutica nei pazienti con danno renale acuto secondario a iperbilirubinemia.

Published
2013

125. Induction of vesicular trafficking and apoptotic signalling in mononuclear leukocytes sign the “immuno-proteostasis” response to uremic proteins.

Author

Bartolini, Desirée, Grignano, Maria Antonietta, Stabile, Anna Maria, Di Sante, Gabriele, Piroddi, Marta, Chiaradia, Elisabetta, Galeazzi, Gabriele, Ronco, Claudio, Rampino, Teresa, Pistilli, Alessandra, Libetta, Carmelo, Galli, Francesco, and Rende, Mario

Abstract

The article focuses on the impact of uremic retention solutes on cell death and molecular changes in peripheral blood mononuclear leukocytes (PBL), suggesting that these solutes induce apoptosis, oxidative stress, endoplasmic reticulum stress, and autophagy in PBL.

Published
2023

128. Multiple electrolyte disorders in a neurosurgical patient: solving the rebus

Author

Corradetti, Valeria, primary, Esposito, Pasquale, additional, Rampino, Teresa, additional, Gregorini, Marilena, additional, Libetta, Carmelo, additional, Bosio, Francesca, additional, Valsania, Teresa, additional, Pattonieri, Eleonora Francesca, additional, Rocca, Chiara, additional, Bianzina, Stefania, additional, and Dal Canton, Antonio, additional

Published
2013
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141. Mesenchymal stromal cells improve renal injury in anti-Thy 1 nephritis by modulating inflammatory cytokines and scatter factors

Author

Rampino, Teresa, primary, Gregorini, Marilena, additional, Bedino, Giulia, additional, Piotti, Giovanni, additional, Gabanti, Elisa, additional, Ibatici, Adalberto, additional, Sessarego, Nadia, additional, Piacenza, Cristina, additional, Balenzano, Chiara Teresa, additional, Esposito, Pasquale, additional, Bosio, Francesca, additional, Soccio, Grazia, additional, Frassoni, Francesco, additional, and Dal Canton, Antonio, additional

Published
2010
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145. KCNA1 and TRPC6 ion channels and NHE1 exchanger operate the biological outcome of HGF/scatter factor in renal tubular cells

Author

Rampino, Teresa, primary, Gregorini, Marilena, additional, Guidetti, Cristina, additional, Broggini, Massimo, additional, Marchini, Sergio, additional, Bonomi, Riccardo, additional, Maggio, Milena, additional, Roscini, Elisabetta, additional, Soccio, Grazia, additional, Tiboldo, Renza, additional, and Canton, Antonio Dal, additional

Published
2007
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146. Evaluation of Cytomegalovirus DNAaemia versus pp65-Antigenaemia Cutoff for Guiding Preemptive therapy in Transplant Recipients: A Randomized Study

Author

Gerna, Giuseppe, primary, Baldanti, Fausto, additional, Torsellini, Maria, additional, Minoli, Lorenzo, additional, Viganò, Mario, additional, Oggionni, Tiberio, additional, Rampino, Teresa, additional, Castiglioni, Barbara, additional, Goglio, Antonio, additional, Colledan, Michele, additional, Mammana, Carmelo, additional, Nozza, Francesca, additional, and Lilleri, Daniele, additional

Published
2007
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