70,807 results on '"Raghavan AS"'
Search Results
102. How does channel integration quality promote omnichannel customer citizenship behavior? The moderating role of the number of channels used and gender
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Natarajan, Thamaraiselvan, Veera Raghavan, Deepak Ramanan, and Jayapal, Jegan
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- 2024
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103. Improving the Robustness of Quantized Deep Neural Networks to White-Box Attacks using Stochastic Quantization and Information-Theoretic Ensemble Training
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Farkya, Saurabh, Raghavan, Aswin, and Ziskind, Avi
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Cryptography and Security ,Computer Science - Machine Learning - Abstract
Most real-world applications that employ deep neural networks (DNNs) quantize them to low precision to reduce the compute needs. We present a method to improve the robustness of quantized DNNs to white-box adversarial attacks. We first tackle the limitation of deterministic quantization to fixed ``bins'' by introducing a differentiable Stochastic Quantizer (SQ). We explore the hypothesis that different quantizations may collectively be more robust than each quantized DNN. We formulate a training objective to encourage different quantized DNNs to learn different representations of the input image. The training objective captures diversity and accuracy via mutual information between ensemble members. Through experimentation, we demonstrate substantial improvement in robustness against $L_\infty$ attacks even if the attacker is allowed to backpropagate through SQ (e.g., > 50\% accuracy to PGD(5/255) on CIFAR10 without adversarial training), compared to vanilla DNNs as well as existing ensembles of quantized DNNs. We extend the method to detect attacks and generate robustness profiles in the adversarial information plane (AIP), towards a unified analysis of different threat models by correlating the MI and accuracy., Comment: 9 pages, 9 figures, 4 tables
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- 2023
104. Unique Factorization For Tensor Products of Parabolic Verma Modules
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Raghavan, K. N., Kumar, V. Sathish, Venkatesh, R., and Viswanath, Sankaran
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Mathematics - Representation Theory ,17B67, 17B10 - Abstract
Let $\mathfrak{g}$ be a symmetrizable Kac-Moody Lie algebra with Cartan subalgebra $\mathfrak{h}$. We prove a unique factorization property for tensor products of parabolic Verma modules. More generally, we prove unique factorization for products of characters of parabolic Verma modules when restricted to certain subalgebras of $\mathfrak{h}$. These include fixed point subalgebras of $\mathfrak{h}$ under subgroups of diagram automorphisms of $\mathfrak{g}$ and twisted graph automorphisms in the affine case., Comment: 20 pages
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- 2023
105. Forward Gradients for Data-Driven CFD Wall Modeling
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Hückelheim, Jan, Kumar, Tadbhagya, Raghavan, Krishnan, and Pal, Pinaki
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Physics - Fluid Dynamics ,Computer Science - Machine Learning - Abstract
Computational Fluid Dynamics (CFD) is used in the design and optimization of gas turbines and many other industrial/ scientific applications. However, the practical use is often limited by the high computational cost, and the accurate resolution of near-wall flow is a significant contributor to this cost. Machine learning (ML) and other data-driven methods can complement existing wall models. Nevertheless, training these models is bottlenecked by the large computational effort and memory footprint demanded by back-propagation. Recent work has presented alternatives for computing gradients of neural networks where a separate forward and backward sweep is not needed and storage of intermediate results between sweeps is not required because an unbiased estimator for the gradient is computed in a single forward sweep. In this paper, we discuss the application of this approach for training a subgrid wall model that could potentially be used as a surrogate in wall-bounded flow CFD simulations to reduce the computational overhead while preserving predictive accuracy.
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- 2023
106. Enhancing Multi-Agent Coordination through Common Operating Picture Integration
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Yu, Peihong, Lee, Bhoram, Raghavan, Aswin, Samarasekara, Supun, Tokekar, Pratap, and Hare, James Zachary
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Computer Science - Multiagent Systems ,Computer Science - Machine Learning ,Computer Science - Robotics - Abstract
In multi-agent systems, agents possess only local observations of the environment. Communication between teammates becomes crucial for enhancing coordination. Past research has primarily focused on encoding local information into embedding messages which are unintelligible to humans. We find that using these messages in agent's policy learning leads to brittle policies when tested on out-of-distribution initial states. We present an approach to multi-agent coordination, where each agent is equipped with the capability to integrate its (history of) observations, actions and messages received into a Common Operating Picture (COP) and disseminate the COP. This process takes into account the dynamic nature of the environment and the shared mission. We conducted experiments in the StarCraft2 environment to validate our approach. Our results demonstrate the efficacy of COP integration, and show that COP-based training leads to robust policies compared to state-of-the-art Multi-Agent Reinforcement Learning (MARL) methods when faced with out-of-distribution initial states., Comment: accepted to OODWorkshop@CoRL23; please see https://openreview.net/forum?id=fADcJl0B0P for the paper
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- 2023
107. Comparative Analysis of Plastid Genomes Using Pangenome Research ToolKit (PGR-TK)
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Jayanti, Richa, Kim, Andrew, Pham, Sean, Raghavan, Athreya, Sharma, Anish, and Samanta, Manoj P.
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Quantitative Biology - Genomics - Abstract
Plastid genomes (plastomes) of angiosperms are of great interest among biologists. High-throughput sequencing is making many such genomes accessible, increasing the need for tools to perform rapid comparative analysis. This exploratory analysis investigates whether the Pangenome Research Tool Kit (PGR-TK) is suitable for analyzing plastomes. After determining the optimal parameters for this tool on plastomes, we use it to compare sequences from each of the genera - Magnolia, Solanum, Fragaria and Cotoneaster, as well as a combined set from 20 rosid genera. PGR-TK recognizes large-scale plastome structures, such as the inverted repeats, among combined sequences from distant rosid families. If the plastid genomes are rotated to the same starting point, it also correctly groups different species from the same genus together in a generated cladogram. The visual approach of PGR-TK provides insights into genome evolution without requiring gene annotations., Comment: 15 pages, 4 figures
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- 2023
108. Uncertainty Quantification-Enabled Inversion of Nuclear Euclidean Responses
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Raghavan, K. and Lovato, A.
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Nuclear Theory ,Nuclear Experiment - Abstract
Nuclear quantum many-body methods rely on integral transform techniques to infer properties of electroweak response functions from ground-state expectation values. Retrieving the energy dependence of these responses is highly non-trivial, especially for quantum Monte Carlo methods, as it requires inverting the Laplace transform -- a notoriously ill-posed problem. In this work, we propose an artificial neural network architecture suitable for accurate response function reconstruction with precise estimation of the uncertainty of the inversion. We demonstrate the capabilities of this new architecture benchmarking it against Maximum Entropy and previously developed neural network methods designed for a similar task, paying particular attention to its robustness against increasing noise in the input Euclidean responses., Comment: 11 pages, 7 figures
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- 2023
109. Content Moderation and the Formation of Online Communities: A Theoretical Framework
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Dwork, Cynthia, Hays, Chris, Kleinberg, Jon, and Raghavan, Manish
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Computer Science - Data Structures and Algorithms ,Computer Science - Computers and Society ,Computer Science - Social and Information Networks - Abstract
We study the impact of content moderation policies in online communities. In our theoretical model, a platform chooses a content moderation policy and individuals choose whether or not to participate in the community according to the fraction of user content that aligns with their preferences. The effects of content moderation, at first blush, might seem obvious: it restricts speech on a platform. However, when user participation decisions are taken into account, its effects can be more subtle $\unicode{x2013}$ and counter-intuitive. For example, our model can straightforwardly demonstrate how moderation policies may increase participation and diversify content available on the platform. In our analysis, we explore a rich set of interconnected phenomena related to content moderation in online communities. We first characterize the effectiveness of a natural class of moderation policies for creating and sustaining stable communities. Building on this, we explore how resource-limited or ideological platforms might set policies, how communities are affected by differing levels of personalization, and competition between platforms. Our model provides a vocabulary and mathematically tractable framework for analyzing platform decisions about content moderation., Comment: 46 pages, 10 figures
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- 2023
110. Self-supervised Learning for Anomaly Detection in Computational Workflows
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Jin, Hongwei, Raghavan, Krishnan, Papadimitriou, George, Wang, Cong, Mandal, Anirban, Deelman, Ewa, and Balaprakash, Prasanna
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Computer Science - Machine Learning ,Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
Anomaly detection is the task of identifying abnormal behavior of a system. Anomaly detection in computational workflows is of special interest because of its wide implications in various domains such as cybersecurity, finance, and social networks. However, anomaly detection in computational workflows~(often modeled as graphs) is a relatively unexplored problem and poses distinct challenges. For instance, when anomaly detection is performed on graph data, the complex interdependency of nodes and edges, the heterogeneity of node attributes, and edge types must be accounted for. Although the use of graph neural networks can help capture complex inter-dependencies, the scarcity of labeled anomalous examples from workflow executions is still a significant challenge. To address this problem, we introduce an autoencoder-driven self-supervised learning~(SSL) approach that learns a summary statistic from unlabeled workflow data and estimates the normal behavior of the computational workflow in the latent space. In this approach, we combine generative and contrastive learning objectives to detect outliers in the summary statistics. We demonstrate that by estimating the distribution of normal behavior in the latent space, we can outperform state-of-the-art anomaly detection methods on our benchmark datasets.
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- 2023
111. A New Spectral Conjugate Subgradient Method with Application in Computed Tomography Image Reconstruction
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Loreto, Milagros, Humphries, Thomas, Raghavan, Chella, Wu, Kenneth, and Kwak, Sam
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Mathematics - Optimization and Control ,90C30, 90C56, 94A08 - Abstract
A new spectral conjugate subgradient method is presented to solve nonsmooth unconstrained optimization problems. The method combines the spectral conjugate gradient method for smooth problems with the spectral subgradient method for nonsmooth problems. We study the effect of two different choices of line search, as well as three formulas for determining the conjugate directions. In addition to numerical experiments with standard nonsmooth test problems, we also apply the method to several image reconstruction problems in computed tomography, using total variation regularization. Performance profiles are used to compare the performance of the algorithm using different line search strategies and conjugate directions to that of the original spectral subgradient method. Our results show that the spectral conjugate subgradient algorithm outperforms the original spectral subgradient method, and that the use of the Polak-Ribiere formula for conjugate directions provides the best and most robust performance., Comment: 23 pages, 7 figures
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- 2023
112. Superconductivity in Compositionally-Complex Cuprates with the YBa$_2$Cu$_3$O$_{7-x}$ Structure
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Raghavan, Aditya, Arndt, Nathan, Morales-Colón, Nayelie, Wennen, Eli, Wolfe, Megan, Gandin, Carolina Oliveira, Nelson, Kade, Nowak, Robert, Dillon, Sam, Sahebkar, Keon, and Need, Ryan F.
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Condensed Matter - Superconductivity ,Condensed Matter - Strongly Correlated Electrons - Abstract
High-temperature superconductivity is reported in a series of compositionally-complex cuprates with varying degrees of size and spin disorder. Three compositions of Y-site alloyed YBa$_2$Cu$_3$O$_{7-x}$, i.e., (5Y)BCO, were prepared using solid-state methods with different sets of rare earth ions on the Y-site. Synchrotron X-ray diffraction and energy-dispersive X-ray spectroscopy confirm these samples have high phase-purity and homogeneous mixing of the Y-site elements. The superconducting phase transition was probed using electrical resistivity and AC magnetometry measurements, which reveal the transition temperature, T$_C$, is greater than 91 K for all series when near optimal oxygen doping. Importantly, these T$_C$ values are only $\approx$1$\%$ suppressed relative to pure YBCO (T$_C$ = 93 K). This result highlights the robustness of pairing in the YBCO structure to specific types of disorder. In addition, the chemical flexibility of compositionally-complex cuprates allows spin and lattice disorder to be decoupled to a degree not previously possible in high-temperature superconductors. This feature makes compositionally-complex cuprates a uniquely well-suited materials platform for studying proposed pairing interactions in cuprates., Comment: 6 pages, 3 figures, 1 table
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- 2023
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113. Unifying inflationary and reheating solution
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Kaur, Manjeet, Nandi, Debottam, and B, Sharath Raghavan
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Astrophysics - Cosmology and Nongalactic Astrophysics ,General Relativity and Quantum Cosmology - Abstract
The conventional background solution for the evolution of a single canonical inflaton field performs admirably in extreme scenarios such as the slow-roll phase (where the slow-roll parameter is much less than one) and the deep reheating era (where the Hubble parameter is much smaller than the effective mass of the potential and the field oscillates around the minimum of the potential), but fails to accurately depict the dynamics of the Universe around the end of inflation and the initial oscillatory phases. This article proposes a single, unified, model-independent, parametrized analytical solution for such models that bridges the gap between these two extremes, providing a near-accurate comprehensive description of the evolution of the Universe. This novel strategy has the potential to substantially enhance both quantitative and qualitative cosmological observational predictions, and, as a consequence, can further constrain the inflationary models more effectively using future observations., Comment: 31 pages, 8 figures, 1 table, Published in JCAP
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- 2023
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114. Self-training Strategies for Sentiment Analysis: An Empirical Study
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Liu, Haochen, Rallabandi, Sai Krishna, Wu, Yijing, Dakle, Parag Pravin, and Raghavan, Preethi
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Computer Science - Computation and Language - Abstract
Sentiment analysis is a crucial task in natural language processing that involves identifying and extracting subjective sentiment from text. Self-training has recently emerged as an economical and efficient technique for developing sentiment analysis models by leveraging a small amount of labeled data and a large amount of unlabeled data. However, given a set of training data, how to utilize them to conduct self-training makes a significant difference in the final performance of the model. We refer to this methodology as the self-training strategy. In this paper, we present an empirical study of various self-training strategies for sentiment analysis. First, we investigate the influence of the self-training strategy and hyper-parameters on the performance of traditional small language models (SLMs) in various few-shot settings. Second, we also explore the feasibility of leveraging large language models (LLMs) to help self-training. We propose and empirically compare several self-training strategies with the intervention of LLMs. Extensive experiments are conducted on three real-world sentiment analysis datasets., Comment: Accepted by EACL Findings 2024
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- 2023
115. Building a Winning Team: Selecting Source Model Ensembles using a Submodular Transferability Estimation Approach
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B, Vimal K, Bachu, Saketh, Garg, Tanmay, Narasimhan, Niveditha Lakshmi, Konuru, Raghavan, and Balasubramanian, Vineeth N
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Estimating the transferability of publicly available pretrained models to a target task has assumed an important place for transfer learning tasks in recent years. Existing efforts propose metrics that allow a user to choose one model from a pool of pre-trained models without having to fine-tune each model individually and identify one explicitly. With the growth in the number of available pre-trained models and the popularity of model ensembles, it also becomes essential to study the transferability of multiple-source models for a given target task. The few existing efforts study transferability in such multi-source ensemble settings using just the outputs of the classification layer and neglect possible domain or task mismatch. Moreover, they overlook the most important factor while selecting the source models, viz., the cohesiveness factor between them, which can impact the performance and confidence in the prediction of the ensemble. To address these gaps, we propose a novel Optimal tranSport-based suBmOdular tRaNsferability metric (OSBORN) to estimate the transferability of an ensemble of models to a downstream task. OSBORN collectively accounts for image domain difference, task difference, and cohesiveness of models in the ensemble to provide reliable estimates of transferability. We gauge the performance of OSBORN on both image classification and semantic segmentation tasks. Our setup includes 28 source datasets, 11 target datasets, 5 model architectures, and 2 pre-training methods. We benchmark our method against current state-of-the-art metrics MS-LEEP and E-LEEP, and outperform them consistently using the proposed approach., Comment: To appear at ICCV 2023
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- 2023
116. An improved framework for mapping and assessment of dynamics in cropping pattern and crop calendar from NDVI time series across a heterogeneous agro-climatic region
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Jeba, R Princy, Kirthiga, S. M., Issac, Annie Maria, Bindhu, V. M., Srinivasan, Raghavan, and Narasimhan, Balaji
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- 2024
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117. Intensive care unit admission rates and factors associated following Autologous stem cell transplantation—real-world experience from a tertiary center in rural India
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Bain, Gourav G., Nair, Chandran K., Shenoy, Praveen K., Raghavan, Vineetha, Menon, Abhilash, and Devi, Nandini
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- 2024
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118. Characterization and quantification of peptaibol produced by novel Trichoderma spp: Harnessing their potential to mitigate moisture stress through enhanced biochemical and physiological responses in black pepper (Piper nigrum L.)
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Valiyambath, Vijayasanthi Kodakkal, Thomas, Titty Anna, George, Priya, Neettiyath Kalathil, Leela, Kaprakkaden, Anees, Subraya, Krishnamurthy Kuntagodu, Raghavan, Dinesh, and Ravindran, Praveena
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- 2024
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119. Dataset Design for Building Models of Chemical Reactivity.
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Raghavan, Priyanka, Haas, Brittany, Ruos, Madeline, Schleinitz, Jules, Reisman, Sarah, Sigman, Matthew, Coley, Connor, and Doyle, Abigail
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Models can codify our understanding of chemical reactivity and serve a useful purpose in the development of new synthetic processes via, for example, evaluating hypothetical reaction conditions or in silico substrate tolerance. Perhaps the most determining factor is the composition of the training data and whether it is sufficient to train a model that can make accurate predictions over the full domain of interest. Here, we discuss the design of reaction datasets in ways that are conducive to data-driven modeling, emphasizing the idea that training set diversity and model generalizability rely on the choice of molecular or reaction representation. We additionally discuss the experimental constraints associated with generating common types of chemistry datasets and how these considerations should influence dataset design and model building.
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- 2023
120. IndicTrans2: Towards High-Quality and Accessible Machine Translation Models for all 22 Scheduled Indian Languages
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Gala, Jay, Chitale, Pranjal A., AK, Raghavan, Gumma, Varun, Doddapaneni, Sumanth, Kumar, Aswanth, Nawale, Janki, Sujatha, Anupama, Puduppully, Ratish, Raghavan, Vivek, Kumar, Pratyush, Khapra, Mitesh M., Dabre, Raj, and Kunchukuttan, Anoop
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Computer Science - Computation and Language - Abstract
India has a rich linguistic landscape with languages from 4 major language families spoken by over a billion people. 22 of these languages are listed in the Constitution of India (referred to as scheduled languages) are the focus of this work. Given the linguistic diversity, high-quality and accessible Machine Translation (MT) systems are essential in a country like India. Prior to this work, there was (i) no parallel training data spanning all 22 languages, (ii) no robust benchmarks covering all these languages and containing content relevant to India, and (iii) no existing translation models which support all the 22 scheduled languages of India. In this work, we aim to address this gap by focusing on the missing pieces required for enabling wide, easy, and open access to good machine translation systems for all 22 scheduled Indian languages. We identify four key areas of improvement: curating and creating larger training datasets, creating diverse and high-quality benchmarks, training multilingual models, and releasing models with open access. Our first contribution is the release of the Bharat Parallel Corpus Collection (BPCC), the largest publicly available parallel corpora for Indic languages. BPCC contains a total of 230M bitext pairs, of which a total of 126M were newly added, including 644K manually translated sentence pairs created as part of this work. Our second contribution is the release of the first n-way parallel benchmark covering all 22 Indian languages, featuring diverse domains, Indian-origin content, and source-original test sets. Next, we present IndicTrans2, the first model to support all 22 languages, surpassing existing models on multiple existing and new benchmarks created as a part of this work. Lastly, to promote accessibility and collaboration, we release our models and associated data with permissive licenses at https://github.com/AI4Bharat/IndicTrans2., Comment: Accepted at TMLR
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- 2023
121. Role of joint interactions in upper limb joint movements: a disability simulation study using wearable inertial sensors for 3D motion capture
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Nishtha Bhagat, Preeti Raghavan, and Vikram Kapila
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Range of motion ,Upper limb ,Joint movement ,Restriction condition ,Disability simulation ,Joint interactions ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Background Restriction of movement at a joint due to disease or dysfunction can alter the range of motion (ROM) at other joints due to joint interactions. In this paper, we quantify the extent to which joint restrictions impact upper limb joint movements by conducting a disability simulation study that used wearable inertial sensors for three-dimensional (3D) motion capture. Methods We employed the Wearable Inertial Sensors for Exergames (WISE) system for assessing the ROM at the shoulder (flexion–extension, abduction–adduction, and internal–external rotation), elbow (flexion–extension), and forearm (pronation-supination). We recruited 20 healthy individuals to first perform instructed shoulder, elbow, and forearm movements without any external restrictions, and then perform the same movements with restriction braces placed to limit movement at the shoulder, elbow, and forearm, separately, to simulate disability. To quantify the extent to which a restriction at a non-instructed joint affected movement at an instructed joint, we computed average percentage reduction in ROM in the restricted versus unrestricted conditions. Moreover, we performed analysis of variance and post hoc Tukey tests (q statistic) to determine the statistical significance (p
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- 2024
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122. Suspension electrospinning of decellularized extracellular matrix: A new method to preserve bioactivity
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Sarah Jones, Sabrina VandenHeuvel, Andres Luengo Martinez, Ruchi Birur, Eric Burgeson, Isabelle Gilbert, Aaron Baker, Matthew Wolf, Shreya A. Raghavan, Simon Rogers, and Elizabeth Cosgriff-Hernandez
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Electrospinning ,Extracellular matrix ,Biological scaffolds ,Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Biology (General) ,QH301-705.5 - Abstract
Decellularized extracellular matrices (dECM) have strong regenerative potential as tissue engineering scaffolds; however, current clinical options for dECM scaffolds are limited to freeze-drying its native form into sheets. Electrospinning is a versatile scaffold fabrication technique that allows control of macro- and microarchitecture. It remains challenging to electrospin dECM, which has led researchers to either blend it with synthetic materials or use enzymatic digestion to fully solubilize the dECM. Both strategies reduce the innate bioactivity of dECM and limit its regenerative potential. Herein, we developed a new suspension electrospinning method to fabricate a pure dECM fibrous mesh that retains its innate bioactivity. Systematic investigation of suspension parameters was used to identify critical rheological properties required to instill “spinnability,” including homogenization, concentration, and particle size. Homogenization enhanced particle interaction to impart the requisite elastic behavior to withstand electrostatic drawing without breaking. A direct correlation between concentration and viscosity was observed that altered fiber morphology; whereas, particle size had minimal impact on suspension properties and fiber morphology. The versatility of this new method was demonstrated by electrospinning dECM with three common decellularization techniques (Abraham, Badylak, Luo) and tissue sources (intestinal submucosa, heart, skin). Bioactivity retention after electrospinning was confirmed using cell proliferation, angiogenesis, and macrophage polarization assays. Collectively, these findings provide a framework for researchers to electrospin dECM for diverse tissue engineering applications.
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- 2024
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123. Epidemiological analysis of Road Accident Data Management System (RADMS) data in Tamil Nadu, India from 2011 to 2016: Future directions for an integrated national database
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Kowshick Raghavan, Sendhilkumar Muthappan, Karunya Ravi, Kathirvel Jothi, Devika Shanmugasundaram, Vettrichelvan Venkatasamy, Ganeshkumar Parasuraman, and Manickam Ponnaiah
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injury surveillance ,radms ,road traffic accidents ,road traffic injuries ,tamil nadu ,Medicine - Abstract
Introduction Globally, road traffic injuries (RTIs) are the eighth leading cause of death, with an estimated 1.35 million deaths yearly. In India, road traffic accidents (RTAs) are one of the major causes of mortality among the younger generation. We analyzed Tamil Nadu’s comprehensive Road Accident Data Management System (RADMS) data and described the epidemiological indicators of RTI in this setting. Methods We obtained the data from the RADMS database for 2011–2016 and used 2011 population census data to project and standardize for different age groups and genders to calculate incidence. We calculated average annual percentage changes (AAPC) with a 95% confidence interval for the whole period. We computed Joinpoint regression analysis for trends and calculated the age-adjusted incidence rate with standard error (SE) using R statistical computing software. Results We included 3,67,094 RTAs and 5,50,447 RTIs. We observed that the incidence of RTAs and RTIs declined between 2011 and 2016. Most injured were males (82%) and aged 20–39 years (49%). The highest number of accidents occurred on the state highways (65.2%) and on Sundays (17%). Age-adjusted incidence (per 1,00,000) declined from 121.87 (SE 0.4) in 2011 to 92.73 (SE 0.34) in 2016 (AAPC = -4.5% (95% CI = -7.8 to -1)). The age groups 30–39 and 20–29 were 9.82 (z = 8.98; P < 0.05) and 9.02 (z = 8.65; P < 0.05) times at a higher risk compared to 0–9 years old. The motorcyclists (14–27 times; P < 0.05) and pedestrians (12–23 times; P < 0.05) had the maximum risk of RTIs. Conclusion Young adults, drivers, motorcyclists, and pedestrians remain vulnerable populations for RTIs. More accidents occurred in the state highways and on Sundays. The analysis provides insights on RTIs and RTAs, which will be used to reduce the burden of RTIs and save millions of lives.
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- 2024
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124. Stress distribution by parafunctional loading on tooth–implant, implant–implant, and tooth–tooth-supported prosthesis: A comparative three-dimensional finite element analysis
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P Ambili Ravindran, Rohit Raghavan, Kiran Christopher, Sethu Sramadathil, Ann George, and Athira Kattachirakunnel Sasi
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dental implant ,finite element analysis ,tooth–implant-supported ,stress distribution ,mandibular molar ,mandibular premolar ,Dentistry ,RK1-715 - Abstract
Aim: The study’s objective was to evaluate the stress distribution in tooth-implant, implant-implant, and tooth-tooth supported prostheses under parafunctional loading in axial and oblique directions employing a 3D finite element analysis in the mandibular posterior region which had D3 bone (porous cortical bone and fine trabecular bone). Setting and Design: In vitro study, Finite element analysis. Meterials and Methods: Cone-beam computed tomography data was used by Mimics software (Materialize Mimics 19) to create a three-dimensional finite element simulation of the jaw. Solid Works 2018 (Dassault Systems) was used to produce a geometric 3D model of the three systems. Each model consisted of a bone, an implant, and teeth (Model I tooth-tooth supported, Model II tooth-implant supported and Model III implant-implant supported). The three models’ geometrical models were transferred to Ansys Workbench (19.2 software) for the analysis portion. A load that mimicked masticatory force was delivered in both axial and oblique directions. Statistical Analysis Used: In the present study, statistical analysis was not required because 3D finite element analysis uses deterministic numerical methods to simulate physical behavior and stress distribution patterns. Result: The results demonstrated that under the parafunctional combined loading process, the implant- implant supported prosthesis showed significantly higher stress concentrations in the bone. It was found that the cortical bone around the crestal region had the highest stresses. Conclusion: Within the constraints of this investigation, we could draw the following conclusion: Of the three models, the tooth-tooth supported prosthesis exhibited the least amount of stress distribution, which was also least when functional loading was applied in the axial direction.
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- 2024
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125. Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis
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Arun Sharma, Neelam Singh, Munmun Bhasin, Prabhakar Tiwari, Pankaj Chopra, Raghavan Varadarajan, and Ramandeep Singh
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Biology (General) ,QH301-705.5 - Abstract
Abstract The expansion of VapBC TA systems in M. tuberculosis has been linked with its fitness and survival upon exposure to stress conditions. Here, we have functionally characterized VapBC13 and VapBC26 TA modules of M. tuberculosis. We report that overexpression of VapC13 and VapC26 toxins in M. tuberculosis results in growth inhibition and transcriptional reprogramming. We have also identified various regulatory proteins as hub nodes in the top response network of VapC13 and VapC26 overexpression strains. Further, analysis of RNA protection ratios revealed potential tRNA targets for VapC13 and VapC26. Using in vitro ribonuclease assays, we demonstrate that VapC13 and VapC26 degrade serT and leuW tRNA, respectively. However, no significant changes in rRNA cleavage profiles were observed upon overexpression of VapC13 and VapC26 in M. tuberculosis. In order to delineate the role of these TA systems in M. tuberculosis physiology, various mutant strains were constructed. We show that in comparison to the parental strain, ΔvapBC13 and ΔvapBC26 strains were mildly susceptible to oxidative stress. Surprisingly, the growth patterns of parental and mutant strains were comparable in aerosol-infected guinea pigs. These observations imply that significant functional redundancy exists for some TA systems from M. tuberculosis.
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- 2024
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126. Broadly potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineages
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Melanie R. Walker, Alexander Underwood, Kasper H. Björnsson, Sai Sundar Rajan Raghavan, Maria R. Bassi, Alekxander Binderup, Long V. Pham, Santseharay Ramirez, Mette Pinholt, Robert Dagil, Anne S. Knudsen, Manja Idorn, Max Soegaard, Kaituo Wang, Andrew B. Ward, Ali Salanti, Jens Bukh, and Lea Barfod
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Biology (General) ,QH301-705.5 - Abstract
Abstract The continuous emergence of SARS-CoV-2 variants of concern has rendered many therapeutic monoclonal antibodies (mAbs) ineffective. To date, there are no clinically authorized therapeutic antibodies effective against the recently circulating Omicron sub-lineages BA.2.86 and JN.1. Here, we report the isolation of broad and potent neutralizing human mAbs (HuMabs) from a healthcare worker infected with SARS-CoV-2 early in the pandemic. These include a genetically unique HuMab, named K501SP6, which can neutralize different Omicron sub-lineages, including BQ.1, XBB.1, BA.2.86 and JN.1, by targeting a highly conserved epitope on the N terminal domain, as well as an RBD-specific HuMab (K501SP3) with high potency towards earlier circulating variants that was escaped by the more recent Omicron sub-lineages through spike F486 and E484 substitutions. Characterizing SARS-CoV-2 spike-specific HuMabs, including broadly reactive non-RBD-specific HuMabs, can give insight into the immune mechanisms involved in neutralization and immune evasion, which can be a valuable addition to already existing SARS-CoV-2 therapies.
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- 2024
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127. Mind the gap in kidney care: Translating what we know into what we do
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Valerie A. Luyckx, Katherine R. Tuttle, Dina Abdellatif, Ricardo Correa-Rotter, Winston W.S. Fung, Agnès Haris, Li-Li Hsiao, Makram Khalife, Latha A. Kumaraswami, Fiona Loud, Vasundhara Raghavan, Stefanos Roumeliotis, Marianella Sierra, Ifeoma Ulasi, Bill Wang, Siu-Fai Lui, Vassilios Liakopoulos, and Alessandro Balducci
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Chronic kidney disease ,Equity ,Kidney care ,Public health ,World kidney day ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Historically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to target. Similarly, the vast majority of people living with kidney disease are unaware of their condition, because in the early stages it is often silent. Even among patients who have been diagnosed, many do not receive appropriate treatment for kidney disease. Considering the serious consequences of kidney disease progression, kidney failure, or death, it is imperative that treatments are initiated early and appropriately. Opportunities to diagnose and treat kidney disease early must be maximized beginning at the primary care level. Many systematic barriers exist, ranging from patient to clinician to health systems to societal factors. To preserve and improve kidney health for everyone everywhere, each of these barriers must be acknowledged so that sustainable solutions are developed and implemented without further delay.
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- 2024
- Full Text
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128. Advanced Abrasive Waterjet for Multimode Machining
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Liu, Peter H.-T., primary, Cutler, Vanessa, additional, Raghavan, Chidambaram, additional, Miles, Peter, additional, Schubert, Ernst, additional, and Webers, Nathan, additional
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- 2024
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129. Engineering good viruses to improve crop performance
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Pasin, Fabio, Uranga, Mireia, Charudattan, Raghavan, and Kwon, Choon-Tak
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- 2024
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130. Atomic-Scale Visualization of a Cascade of Magnetic Orders in the Layered Antiferromagnet $GdTe_{3}$
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Raghavan, Arjun, Romanelli, Marisa, May-Mann, Julian, Aishwarya, Anuva, Aggarwal, Leena, Singh, Anisha G., Bachmann, Maja D., Schoop, Leslie M., Fradkin, Eduardo, Fisher, Ian R., and Madhavan, Vidya
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Condensed Matter - Strongly Correlated Electrons - Abstract
$GdTe_{3}$ is a layered antiferromagnet which has attracted attention due to its exceptionally high mobility, distinctive unidirectional incommensurate charge density wave (CDW), superconductivity under pressure, and a cascade of magnetic transitions between 7 and 12 K, with as yet unknown order parameters. Here, we use spin-polarized scanning tunneling microscopy to directly image the charge and magnetic orders in $GdTe_{3}$. Below 7 K, we find a striped antiferromagnetic phase with twice the periodicity of the Gd lattice and perpendicular to the CDW. As we heat the sample, we discover a spin density wave with the same periodicity as the CDW between 7 and 12 K; the viability of this phase is supported by our Landau free energy model. Our work reveals the order parameters of the magnetic phases in $GdTe_{3}$ and shows how the interplay between charge and spin can generate a cascade of magnetic orders., Comment: 46 pgs.; 4 main figures, 20 supplementary figures
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- 2023
- Full Text
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131. SoK: The Ghost Trilemma
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Mukherjee, Sulagna, Ravi, Srivatsan, Schmitt, Paul, and Raghavan, Barath
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Computer Science - Cryptography and Security ,Computer Science - Computers and Society ,D.4.6 ,H.5 ,K.4 - Abstract
Trolls, bots, and sybils distort online discourse and compromise the security of networked platforms. User identity is central to the vectors of attack and manipulation employed in these contexts. However it has long seemed that, try as it might, the security community has been unable to stem the rising tide of such problems. We posit the Ghost Trilemma, that there are three key properties of identity -- sentience, location, and uniqueness -- that cannot be simultaneously verified in a fully-decentralized setting. Many fully-decentralized systems -- whether for communication or social coordination -- grapple with this trilemma in some way, perhaps unknowingly. In this Systematization of Knowledge (SoK) paper, we examine the design space, use cases, problems with prior approaches, and possible paths forward. We sketch a proof of this trilemma and outline options for practical, incrementally deployable schemes to achieve an acceptable tradeoff of trust in centralized trust anchors, decentralized operation, and an ability to withstand a range of attacks, while protecting user privacy., Comment: 22 pages with 1 figure and 8 tables
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- 2023
132. Efficient Model Adaptation for Continual Learning at the Edge
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Daniels, Zachary A., Hu, Jun, Lomnitz, Michael, Miller, Phil, Raghavan, Aswin, Zhang, Joe, Piacentino, Michael, and Zhang, David
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Most machine learning (ML) systems assume stationary and matching data distributions during training and deployment. This is often a false assumption. When ML models are deployed on real devices, data distributions often shift over time due to changes in environmental factors, sensor characteristics, and task-of-interest. While it is possible to have a human-in-the-loop to monitor for distribution shifts and engineer new architectures in response to these shifts, such a setup is not cost-effective. Instead, non-stationary automated ML (AutoML) models are needed. This paper presents the Encoder-Adaptor-Reconfigurator (EAR) framework for efficient continual learning under domain shifts. The EAR framework uses a fixed deep neural network (DNN) feature encoder and trains shallow networks on top of the encoder to handle novel data. The EAR framework is capable of 1) detecting when new data is out-of-distribution (OOD) by combining DNNs with hyperdimensional computing (HDC), 2) identifying low-parameter neural adaptors to adapt the model to the OOD data using zero-shot neural architecture search (ZS-NAS), and 3) minimizing catastrophic forgetting on previous tasks by progressively growing the neural architecture as needed and dynamically routing data through the appropriate adaptors and reconfigurators for handling domain-incremental and class-incremental continual learning. We systematically evaluate our approach on several benchmark datasets for domain adaptation and demonstrate strong performance compared to state-of-the-art algorithms for OOD detection and few-/zero-shot NAS., Comment: Unpublished White Paper
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- 2023
133. Reconciling the accuracy-diversity trade-off in recommendations
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Peng, Kenny, Raghavan, Manish, Pierson, Emma, Kleinberg, Jon, and Garg, Nikhil
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Computer Science - Information Retrieval ,Computer Science - Social and Information Networks - Abstract
In recommendation settings, there is an apparent trade-off between the goals of accuracy (to recommend items a user is most likely to want) and diversity (to recommend items representing a range of categories). As such, real-world recommender systems often explicitly incorporate diversity separately from accuracy. This approach, however, leaves a basic question unanswered: Why is there a trade-off in the first place? We show how the trade-off can be explained via a user's consumption constraints -- users typically only consume a few of the items they are recommended. In a stylized model we introduce, objectives that account for this constraint induce diverse recommendations, while objectives that do not account for this constraint induce homogeneous recommendations. This suggests that accuracy and diversity appear misaligned because standard accuracy metrics do not consider consumption constraints. Our model yields precise and interpretable characterizations of diversity in different settings, giving practical insights into the design of diverse recommendations., Comment: 34 pages, 5 figures
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- 2023
134. Competing mechanisms govern the thermal rectification behavior in semi-stochastic polycrystalline graphene with graded grain-size distribution
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Lahkar, Simanta and Ranganathan, Raghavan
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Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Thermal rectifiers are devices that have different thermal conductivities in opposing directions of heat flow. The realization of practical thermal rectifiers relies significantly on a sound understanding of the underlying mechanisms of asymmetric heat transport, and two-dimensional materials offer a promising opportunity in this regard owing to their simplistic structures together with a vast possibility of tunable imperfections. However, the in-plane thermal rectification mechanisms in 2D materials like graphene having directional gradients of grain sizes have remained elusive. In fact, understanding the heat transport mechanisms in polycrystalline graphene, which are more practical to synthesize than large-scale single-crystal graphene, could potentially allow a unique opportunity, in principle, to combine with other defects and designs for effective optimization of thermal rectification. In this work, we investigate the thermal rectification behavior in periodic atomistic models of polycrystalline graphene whose grain arrangements were generated semi-stochastically to have different gradient grain-density distributions along the in-plane heat flow direction. We employ the centroidal Voronoi tessellation technique to generate realistic grain boundary structures for graphene, and the non-equilibrium molecular dynamics simulations method is used to calculate the thermal conductivities and rectification values. Additionally, detailed phonon characteristics and propagating phonon spatial energy densities are analyzed based on the fluctuation-dissipation theory to elucidate the competitive interplay between two underlying mechanisms, namely, (1) propagating phonon coupling and (2) temperature-dependence of thermal conductivity that determine the degree of asymmetric heat flow in graded polycrystalline graphene., Comment: This is an early draft. The final paper has been published in the journal 'Carbon'. Link to the published version that includes a new figure on the relative interaction strength of the two mechanisms in graded poly-graphene, as well as other revised text and figures/data: https://authors.elsevier.com/a/1iCb%7E1zUAW0L5 (can be accessed free of cost using this link until January 24, 2024)
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- 2023
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135. Hidden Markov Models with Random Restarts vs Boosting for Malware Detection
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Raghavan, Aditya, Di Troia, Fabio, and Stamp, Mark
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Computer Science - Cryptography and Security ,Computer Science - Machine Learning - Abstract
Effective and efficient malware detection is at the forefront of research into building secure digital systems. As with many other fields, malware detection research has seen a dramatic increase in the application of machine learning algorithms. One machine learning technique that has been used widely in the field of pattern matching in general-and malware detection in particular-is hidden Markov models (HMMs). HMM training is based on a hill climb, and hence we can often improve a model by training multiple times with different initial values. In this research, we compare boosted HMMs (using AdaBoost) to HMMs trained with multiple random restarts, in the context of malware detection. These techniques are applied to a variety of challenging malware datasets. We find that random restarts perform surprisingly well in comparison to boosting. Only in the most difficult "cold start" cases (where training data is severely limited) does boosting appear to offer sufficient improvement to justify its higher computational cost in the scoring phase.
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- 2023
136. Model Adaptation for ASR in low-resource Indian Languages
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Singh, Abhayjeet, Mehta, Arjun Singh, S, Ashish Khuraishi K, G, Deekshitha, Date, Gauri, Nanavati, Jai, Bandekar, Jesuraja, Basumatary, Karnalius, P, Karthika, Badiger, Sandhya, Udupa, Sathvik, Kumar, Saurabh, Savitha, Ghosh, Prasanta Kumar, V, Prashanthi, Pai, Priyanka, Nanavati, Raoul, Saxena, Rohan, Mora, Sai Praneeth Reddy, and Raghavan, Srinivasa
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Electrical Engineering and Systems Science - Audio and Speech Processing ,Computer Science - Computation and Language - Abstract
Automatic speech recognition (ASR) performance has improved drastically in recent years, mainly enabled by self-supervised learning (SSL) based acoustic models such as wav2vec2 and large-scale multi-lingual training like Whisper. A huge challenge still exists for low-resource languages where the availability of both audio and text is limited. This is further complicated by the presence of multiple dialects like in Indian languages. However, many Indian languages can be grouped into the same families and share the same script and grammatical structure. This is where a lot of adaptation and fine-tuning techniques can be applied to overcome the low-resource nature of the data by utilising well-resourced similar languages. In such scenarios, it is important to understand the extent to which each modality, like acoustics and text, is important in building a reliable ASR. It could be the case that an abundance of acoustic data in a language reduces the need for large text-only corpora. Or, due to the availability of various pretrained acoustic models, the vice-versa could also be true. In this proposed special session, we encourage the community to explore these ideas with the data in two low-resource Indian languages of Bengali and Bhojpuri. These approaches are not limited to Indian languages, the solutions are potentially applicable to various languages spoken around the world., Comment: ASRU Special session overview paper
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- 2023
137. Neural Free-Viewpoint Relighting for Glossy Indirect Illumination
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Raghavan, Nithin, Xiao, Yan, Lin, Kai-En, Sun, Tiancheng, Bi, Sai, Xu, Zexiang, Li, Tzu-Mao, and Ramamoorthi, Ravi
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Computer Science - Graphics ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Precomputed Radiance Transfer (PRT) remains an attractive solution for real-time rendering of complex light transport effects such as glossy global illumination. After precomputation, we can relight the scene with new environment maps while changing viewpoint in real-time. However, practical PRT methods are usually limited to low-frequency spherical harmonic lighting. All-frequency techniques using wavelets are promising but have so far had little practical impact. The curse of dimensionality and much higher data requirements have typically limited them to relighting with fixed view or only direct lighting with triple product integrals. In this paper, we demonstrate a hybrid neural-wavelet PRT solution to high-frequency indirect illumination, including glossy reflection, for relighting with changing view. Specifically, we seek to represent the light transport function in the Haar wavelet basis. For global illumination, we learn the wavelet transport using a small multi-layer perceptron (MLP) applied to a feature field as a function of spatial location and wavelet index, with reflected direction and material parameters being other MLP inputs. We optimize/learn the feature field (compactly represented by a tensor decomposition) and MLP parameters from multiple images of the scene under different lighting and viewing conditions. We demonstrate real-time (512 x 512 at 24 FPS, 800 x 600 at 13 FPS) precomputed rendering of challenging scenes involving view-dependent reflections and even caustics., Comment: 13 pages, 9 figures, to appear in cgf proceedings of egsr 2023
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- 2023
138. Robust atmospherically stable hybrid SrVO3/Graphene//SrTiO3 template for fast and facile large-area transfer of complex oxides onto Si
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Haque, Asraful, Mandal, Suman Kumar, Jeyaseelan, Antony, Vura, Sandeep, Nukala, Pavan, and Raghavan, Srinivasan
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Condensed Matter - Materials Science - Abstract
Heterogenous integration of complex epitaxial oxides onto Si and other target substrates is recently gaining traction. One of the popular methods involves growing a water-soluble and highly reactive sacrificial buffer layer, such as Sr3Al2O6 (SAO) at the interface, and a functional oxide on top of this. To improve the versatility of layer transfer techniques, it is desired to utilize stable (less reactive) sacrificial layers, without compromising on the transfer rates. In this study, we utilized a combination of chemical vapor deposited (CVD) graphene as a 2D material at the interface and pulsed laser deposited (PLD) water-soluble SrVO3 (SVO) as a sacrificial buffer layer. We show that the graphene layer enhances the dissolution rate of SVO over ten times without compromising its atmospheric stability. We demonstrate the versatility of our hybrid template by growing ferroelectric BaTiO3 (BTO) via PLD and Pb(Zr, Ti)O3 (PZT) via Chemical Solution Deposition (CSD) technique and transferring them onto the target substrates and establishing their ferroelectric properties. Our hybrid templates allow for the realization of the potential of complex oxides in a plethora of device applications for MEMS, electro-optics, and flexible electronics., Comment: 35 pages, 23 figures
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- 2023
139. Flow-Bench: A Dataset for Computational Workflow Anomaly Detection
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Papadimitriou, George, Jin, Hongwei, Wang, Cong, Mayani, Rajiv, Raghavan, Krishnan, Mandal, Anirban, Balaprakash, Prasanna, and Deelman, Ewa
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Computer Science - Distributed, Parallel, and Cluster Computing - Abstract
A computational workflow, also known as workflow, consists of tasks that must be executed in a specific order to attain a specific goal. Often, in fields such as biology, chemistry, physics, and data science, among others, these workflows are complex and are executed in large-scale, distributed, and heterogeneous computing environments prone to failures and performance degradation. Therefore, anomaly detection for workflows is an important paradigm that aims to identify unexpected behavior or errors in workflow execution. This crucial task to improve the reliability of workflow executions can be further assisted by machine learning-based techniques. However, such application is limited, in large part, due to the lack of open datasets and benchmarking. To address this gap, we make the following contributions in this paper: (1) we systematically inject anomalies and collect raw execution logs from workflows executing on distributed infrastructures; (2) we summarize the statistics of new datasets, and provide insightful analyses; (3) we convert workflows into tabular, graph and text data, and benchmark with supervised and unsupervised anomaly detection techniques correspondingly. The presented dataset and benchmarks allow examining the effectiveness and efficiency of scientific computational workflows and identifying potential research opportunities for improvement and generalization. The dataset and benchmark code are publicly available \url{https://poseidon-workflows.github.io/FlowBench/} under the MIT License., Comment: Work under review, updated with more workflow data
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- 2023
140. StyleTTS 2: Towards Human-Level Text-to-Speech through Style Diffusion and Adversarial Training with Large Speech Language Models
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Li, Yinghao Aaron, Han, Cong, Raghavan, Vinay S., Mischler, Gavin, and Mesgarani, Nima
- Subjects
Electrical Engineering and Systems Science - Audio and Speech Processing ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language ,Computer Science - Machine Learning ,Computer Science - Sound - Abstract
In this paper, we present StyleTTS 2, a text-to-speech (TTS) model that leverages style diffusion and adversarial training with large speech language models (SLMs) to achieve human-level TTS synthesis. StyleTTS 2 differs from its predecessor by modeling styles as a latent random variable through diffusion models to generate the most suitable style for the text without requiring reference speech, achieving efficient latent diffusion while benefiting from the diverse speech synthesis offered by diffusion models. Furthermore, we employ large pre-trained SLMs, such as WavLM, as discriminators with our novel differentiable duration modeling for end-to-end training, resulting in improved speech naturalness. StyleTTS 2 surpasses human recordings on the single-speaker LJSpeech dataset and matches it on the multispeaker VCTK dataset as judged by native English speakers. Moreover, when trained on the LibriTTS dataset, our model outperforms previous publicly available models for zero-shot speaker adaptation. This work achieves the first human-level TTS on both single and multispeaker datasets, showcasing the potential of style diffusion and adversarial training with large SLMs. The audio demos and source code are available at https://styletts2.github.io/., Comment: NeurIPS 2023
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- 2023
141. Towards Efficient Controller Synthesis Techniques for Logical LTL Games
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Samuel, Stanly, D'Souza, Deepak, and Komondoor, Raghavan
- Subjects
Computer Science - Logic in Computer Science ,Computer Science - Formal Languages and Automata Theory ,Computer Science - Symbolic Computation ,Electrical Engineering and Systems Science - Systems and Control - Abstract
Two-player games are a fruitful way to represent and reason about several important synthesis tasks. These tasks include controller synthesis (where one asks for a controller for a given plant such that the controlled plant satisfies a given temporal specification), program repair (setting values of variables to avoid exceptions), and synchronization synthesis (adding lock/unlock statements in multi-threaded programs to satisfy safety assertions). In all these applications, a solution directly corresponds to a winning strategy for one of the players in the induced game. In turn, \emph{logically-specified} games offer a powerful way to model these tasks for large or infinite-state systems. Much of the techniques proposed for solving such games typically rely on abstraction-refinement or template-based solutions. In this paper, we show how to apply classical fixpoint algorithms, that have hitherto been used in explicit, finite-state, settings, to a symbolic logical setting. We implement our techniques in a tool called GenSys-LTL and show that they are not only effective in synthesizing valid controllers for a variety of challenging benchmarks from the literature, but often compute maximal winning regions and maximally-permissive controllers. We achieve \textbf{46.38X speed-up} over the state of the art and also scale well for non-trivial LTL specifications.
- Published
- 2023
142. Auditing for Human Expertise
- Author
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Alur, Rohan, Laine, Loren, Li, Darrick K., Raghavan, Manish, Shah, Devavrat, and Shung, Dennis
- Subjects
Statistics - Machine Learning ,Computer Science - Computers and Society ,Computer Science - Machine Learning - Abstract
High-stakes prediction tasks (e.g., patient diagnosis) are often handled by trained human experts. A common source of concern about automation in these settings is that experts may exercise intuition that is difficult to model and/or have access to information (e.g., conversations with a patient) that is simply unavailable to a would-be algorithm. This raises a natural question whether human experts add value which could not be captured by an algorithmic predictor. We develop a statistical framework under which we can pose this question as a natural hypothesis test. Indeed, as our framework highlights, detecting human expertise is more subtle than simply comparing the accuracy of expert predictions to those made by a particular learning algorithm. Instead, we propose a simple procedure which tests whether expert predictions are statistically independent from the outcomes of interest after conditioning on the available inputs (`features'). A rejection of our test thus suggests that human experts may add value to any algorithm trained on the available data, and has direct implications for whether human-AI `complementarity' is achievable in a given prediction task. We highlight the utility of our procedure using admissions data collected from the emergency department of a large academic hospital system, where we show that physicians' admit/discharge decisions for patients with acute gastrointestinal bleeding (AGIB) appear to be incorporating information that is not available to a standard algorithmic screening tool. This is despite the fact that the screening tool is arguably more accurate than physicians' discretionary decisions, highlighting that -- even absent normative concerns about accountability or interpretability -- accuracy is insufficient to justify algorithmic automation., Comment: 30 pages, 10 figures. To appear in the proceedings of the 37th Conference on Neural Information Processing Systems (NeurIPS 2023)
- Published
- 2023
143. Operational Clarity: Pre and Post Laryngoscope Checklist
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Gaikwad, Sakshi, Kawale, Rajesh, Waknis, Pushkar P., and Raghavan, Ria
- Published
- 2024
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144. Clonal Hematopoiesis of Indeterminate Potential (CHIP) and Incident Type 2 Diabetes Risk.
- Author
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Tobias, Deirdre K, Manning, Alisa K, Wessel, Jennifer, Raghavan, Sridharan, Westerman, Kenneth E, Bick, Alexander G, Dicorpo, Daniel, Whitsel, Eric A, Collins, Jason, Correa, Adolfo, Cupples, L Adrienne, Dupuis, Josée, Goodarzi, Mark O, Guo, Xiuqing, Howard, Barbara, Lange, Leslie A, Liu, Simin, Raffield, Laura M, Reiner, Alex P, Rich, Stephen S, Taylor, Kent D, Tinker, Lesley, Wilson, James G, Wu, Peitao, Carson, April P, Vasan, Ramachandran S, Fornage, Myriam, Psaty, Bruce M, Kooperberg, Charles, Rotter, Jerome I, Meigs, James, and Manson, JoAnn E
- Subjects
Epidemiology ,Biomedical and Clinical Sciences ,Health Sciences ,Prevention ,Cardiovascular ,Precision Medicine ,Stem Cell Research ,Diabetes ,Heart Disease ,Hematology ,Aging ,Obesity ,Genetics ,2.1 Biological and endogenous factors ,Cancer ,Metabolic and endocrine ,Good Health and Well Being ,Humans ,Female ,Middle Aged ,Male ,Clonal Hematopoiesis ,Diabetes Mellitus ,Type 2 ,Prospective Studies ,Hematopoiesis ,Clonal Evolution ,Coronary Disease ,Mutation ,TOPMed Diabetes Working Group and National Heart ,Lung ,and Blood Institute TOPMed Consortium - Abstract
ObjectiveClonal hematopoiesis of indeterminate potential (CHIP) is an aging-related accumulation of somatic mutations in hematopoietic stem cells, leading to clonal expansion. CHIP presence has been implicated in atherosclerotic coronary heart disease (CHD) and all-cause mortality, but its association with incident type 2 diabetes (T2D) is unknown. We hypothesized that CHIP is associated with elevated risk of T2D.Research design and methodsCHIP was derived from whole-genome sequencing of blood DNA in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) prospective cohorts. We performed analysis for 17,637 participants from six cohorts, without prior T2D, cardiovascular disease, or cancer. We evaluated baseline CHIP versus no CHIP prevalence with incident T2D, including associations with DNMT3A, TET2, ASXL1, JAK2, and TP53 variants. We estimated multivariable-adjusted hazard ratios (HRs) and 95% CIs with adjustment for age, sex, BMI, smoking, alcohol, education, self-reported race/ethnicity, and combined cohorts' estimates via fixed-effects meta-analysis.ResultsMean (SD) age was 63.4 (11.5) years, 76% were female, and CHIP prevalence was 6.0% (n = 1,055) at baseline. T2D was diagnosed in n = 2,467 over mean follow-up of 9.8 years. Participants with CHIP had 23% (CI 1.04, 1.45) higher risk of T2D than those with no CHIP. Specifically, higher risk was for TET2 (HR 1.48; CI 1.05, 2.08) and ASXL1 (HR 1.76; CI 1.03, 2.99) mutations; DNMT3A was nonsignificant (HR 1.15; CI 0.93, 1.43). Statistical power was limited for JAK2 and TP53 analyses.ConclusionsCHIP was associated with higher incidence of T2D. CHIP mutations located on genes implicated in CHD and mortality were also related to T2D, suggesting shared aging-related pathology.
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- 2023
145. Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
- Author
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Tobias, Deirdre K, Merino, Jordi, Ahmad, Abrar, Aiken, Catherine, Benham, Jamie L, Bodhini, Dhanasekaran, Clark, Amy L, Colclough, Kevin, Corcoy, Rosa, Cromer, Sara J, Duan, Daisy, Felton, Jamie L, Francis, Ellen C, Gillard, Pieter, Gingras, Véronique, Gaillard, Romy, Haider, Eram, Hughes, Alice, Ikle, Jennifer M, Jacobsen, Laura M, Kahkoska, Anna R, Kettunen, Jarno LT, Kreienkamp, Raymond J, Lim, Lee-Ling, Männistö, Jonna ME, Massey, Robert, Mclennan, Niamh-Maire, Miller, Rachel G, Morieri, Mario Luca, Most, Jasper, Naylor, Rochelle N, Ozkan, Bige, Patel, Kashyap Amratlal, Pilla, Scott J, Prystupa, Katsiaryna, Raghavan, Sridharan, Rooney, Mary R, Schön, Martin, Semnani-Azad, Zhila, Sevilla-Gonzalez, Magdalena, Svalastoga, Pernille, Takele, Wubet Worku, Tam, Claudia Ha-ting, Thuesen, Anne Cathrine B, Tosur, Mustafa, Wallace, Amelia S, Wang, Caroline C, Wong, Jessie J, Yamamoto, Jennifer M, Young, Katherine, Amouyal, Chloé, Andersen, Mette K, Bonham, Maxine P, Chen, Mingling, Cheng, Feifei, Chikowore, Tinashe, Chivers, Sian C, Clemmensen, Christoffer, Dabelea, Dana, Dawed, Adem Y, Deutsch, Aaron J, Dickens, Laura T, DiMeglio, Linda A, Dudenhöffer-Pfeifer, Monika, Evans-Molina, Carmella, Fernández-Balsells, María Mercè, Fitipaldi, Hugo, Fitzpatrick, Stephanie L, Gitelman, Stephen E, Goodarzi, Mark O, Grieger, Jessica A, Guasch-Ferré, Marta, Habibi, Nahal, Hansen, Torben, Huang, Chuiguo, Harris-Kawano, Arianna, Ismail, Heba M, Hoag, Benjamin, Johnson, Randi K, Jones, Angus G, Koivula, Robert W, Leong, Aaron, Leung, Gloria KW, Libman, Ingrid M, Liu, Kai, Long, S Alice, Lowe, William L, Morton, Robert W, Motala, Ayesha A, Onengut-Gumuscu, Suna, Pankow, James S, Pathirana, Maleesa, Pazmino, Sofia, Perez, Dianna, Petrie, John R, Powe, Camille E, Quinteros, Alejandra, Jain, Rashmi, Ray, Debashree, and Ried-Larsen, Mathias
- Subjects
Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Health Services ,Diabetes ,Clinical Research ,Pediatric ,Metabolic and endocrine ,Good Health and Well Being ,Humans ,Precision Medicine ,Consensus ,Diabetes Mellitus ,Evidence-Based Medicine ,Medical and Health Sciences ,Immunology ,Biomedical and clinical sciences ,Health sciences - Abstract
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
- Published
- 2023
146. Quantitative Internal-Ballistics Prediction and Design
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Krishnan, Subramaniam, Raghavan, Jeenu, Krishnan, Subramaniam, and Raghavan, Jeenu
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- 2024
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147. Propulsion System Classification
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Krishnan, Subramaniam, Raghavan, Jeenu, Krishnan, Subramaniam, and Raghavan, Jeenu
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- 2024
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148. Stage Optimization and Trajectories
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Krishnan, Subramaniam, Raghavan, Jeenu, Krishnan, Subramaniam, and Raghavan, Jeenu
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- 2024
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149. History of Rockets
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Krishnan, Subramaniam, Raghavan, Jeenu, Krishnan, Subramaniam, and Raghavan, Jeenu
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- 2024
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150. Qualitative-Performance and Technology
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Krishnan, Subramaniam, Raghavan, Jeenu, Krishnan, Subramaniam, and Raghavan, Jeenu
- Published
- 2024
- Full Text
- View/download PDF
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