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609 results on '"Qin, Lu-Ping"'

102. Monotropein attenuates ovariectomy and LPS-induced bone loss in mice and decreases inflammatory impairment on osteoblast through blocking activation of NF-κB pathway

Author

He, Yu-Qiong, primary, Yang, Hua, additional, Shen, Yi, additional, Zhang, Jian-Hua, additional, Zhang, Zhi-Guo, additional, Liu, Lin-Lin, additional, Song, Hong-Tao, additional, Lin, Bin, additional, Hsu, Hsien-Yeh, additional, Qin, Lu-Ping, additional, Han, Ting, additional, Xin, Hai-Liang, additional, and Zhang, Qiao-Yan, additional

Published
2018
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108. Flavonoids from Caragana pruinosa roots

Author

Peng, Wei, primary, Wang, Liang, additional, Qiu, Xu-Hui, additional, Jiang, Yi-Ping, additional, Pan, Lan, additional, Jia, Xiao-Guang, additional, Qin, Lu-Ping, additional, and Zheng, Cheng-Jian, additional

Published
2016
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111. Coordinate regulatory osteogenesis effects of icariin, timosaponin B II and ferulic acid from traditional Chinese medicine formulas on UMR-106 osteoblastic cells and osteoblasts in neonatal rat calvaria cultures

Author

Li, Mei, primary, Zhang, Nai-Dan, additional, Wang, Yin, additional, Han, Ting, additional, Jiang, Yi-Ping, additional, Rahman, Khalid, additional, Qin, Lu-Ping, additional, Xin, Hai-Liang, additional, and Zhang, Qiao-Yan, additional

Published
2016
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118. Potential Antiosteoporotic Agents from Plants: A Comprehensive Review

Author

Jia, Min, Nie, Yan, Cao, Da-Peng, Xue, Yun-Yun, Wang, Jie-Si, Zhao, Lu, Rahman, Khalid, Zhang, Qiao-Yan, and Qin, Lu-Ping

Subjects
Article Subject, food and beverages
Abstract

Osteoporosis is a major health hazard and is a disease of old age; it is a silent epidemic affecting more than 200 million people worldwide in recent years. Based on a large number of chemical and pharmacological research many plants and their compounds have been shown to possess antiosteoporosis activity. This paper reviews the medicinal plants displaying antiosteoporosis properties including their origin, active constituents, and pharmacological data. The plants reported here are the ones which are commonly used in traditional medical systems and have demonstrated clinical effectiveness against osteoporosis. Although many plants have the potential to prevent and treat osteoporosis, so far, only a fraction of these plants have been thoroughly investigated for their physiological and pharmacological properties including their mechanism of action. An attempt should be made to highlight plant species with possible antiosteoporosis properties and they should be investigated further to help with future drug development for treating this disease.

Published
2012
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123. The regulatory mechanism of fungal elicitor-induced secondary metabolite biosynthesis in medical plants.

Author

Zhai, Xin, Jia, Min, Chen, Ling, Zheng, Cheng-jian, Rahman, Khalid, Han, Ting, and Qin, Lu-ping

Subjects
ELICITORS (Botany), METABOLITE synthesis, MEDICINAL plants, CELLULAR signal transduction, GENE expression
Abstract

A wide range of external stress stimuli trigger plant cells to undergo complex network of reactions that ultimately lead to the synthesis and accumulation of secondary metabolites. Accumulation of such metabolites often occurs in plants subjected to stresses including various elicitors or signal molecules. Throughout evolution, endophytic fungi, an important constituent in the environment of medicinal plants, have known to form long-term stable and mutually beneficial symbiosis with medicinal plants. The endophytic fungal elicitor can rapidly and specifically induce the expression of specific genes in medicinal plants which can result in the activation of a series of specific secondary metabolic pathways resulting in the significant accumulation of active ingredients. Here we summarize the progress made on the mechanisms of fungal elicitor including elicitor signal recognition, signal transduction, gene expression and activation of the key enzymes and its application. This review provides guidance on studies which may be conducted to promote the efficient synthesis and accumulation of active ingredients by the endogenous fungal elicitor in medicinal plant cells, and provides new ideas and methods of studying the regulation of secondary metabolism in medicinal plants. [ABSTRACT FROM AUTHOR]

Published
2017
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137. Plants and cervical cancer: an overview

Author

Wang, Su-Juan, primary, Zheng, Cheng-Jian, additional, Peng, Cheng, additional, Zhang, Hong, additional, Jiang, Yi-Ping, additional, Han, Ting, additional, and Qin, Lu-Ping, additional

Published
2013
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142. Endophytic fungi with antitumor activities: Their occurrence and anticancer compounds.

Author

Chen, Ling, Zhang, Qiao-Yan, Jia, Min, Ming, Qian-Liang, Yue, Wei, Rahman, Khalid, Qin, Lu-Ping, and Han, Ting

Subjects
PHYTOPATHOGENIC fungi, BIOACTIVE compounds, PLANT products, ANTINEOPLASTIC agents, MYCOLOGISTS, ASPERGILLUS
Abstract

Plant endophytic fungi have been recognized as an important and novel resource of natural bioactive products, especially in anticancer application. This review mainly deals with the research progress on the production of anticancer compounds by endophytic fungi between 1990 and 2013. Anticancer activity is generally associated with the cytotoxicity of the compounds present in the endophytic fungi. All strains of endophytes producing antitumor chemicals were classified taxonomically and the genera of Pestalotiopsis and Aspergillus as well as the taxol producing endophytes were focused on. Classification of endophytic fungi producing antitumor compounds has received more attention from mycologists, and it can also lead to the discovery of novel compounds with antitumor activity due to phylogenetic relationships. In this review, the structures of the anticancer compounds isolated from the newly reported endophytes between 2010 and 2013 are discussed including strategies for the efficient production of the desired compounds. The purpose of this review is to provide new directions in endophytic fungi research including integrated information relating to its anticancer compounds. [ABSTRACT FROM AUTHOR]

Published
2016
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143. Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites.

Author

Yue, Wei, Ming, Qian-liang, Lin, Bing, Rahman, Khalid, Zheng, Cheng-Jian, Han, Ting, and Qin, Lu-ping

Subjects
MEDICINAL plants, CELL suspensions, PLANT cell culture, METABOLITES, PLANT tissue culture
Abstract

The development of plant tissue (including organ and cell) cultures for the production of secondary metabolites has been underway for more than three decades. Plant cell cultures with the production of high-value secondary metabolites are promising potential alternative sources for the production of pharmaceutical agents of industrial importance. Medicinal plant cell suspension cultures (MPCSC), which are characterized with the feature of fermentation with plant cell totipotency, could be a promising alternative “chemical factory”. However, low productivity becomes an inevitable obstacle limiting further commercialization of MPCSC and the application to large-scale production is still limited to a few processes. This review generalizes and analyzes the recent progress of this bioproduction platform for the provision of medicinal chemicals and outlines a range of trials taken or underway to increase product yields from MPCSC. The scale-up of MPCSC, which could lead to an unlimited supply of pharmaceuticals, including strategies to overcome and solution of the associated challenges, is discussed. [ABSTRACT FROM PUBLISHER]

Published
2016
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