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Automatic delineation of organ-at-risk (OAR) and gross-tumor-volume (GTV) is of great significance for radiotherapy planning. However, it is a challenging task to learn powerful representations for accurate delineation under limited pixel (voxel)-wise annotations. Contrastive learning at pixel-level can alleviate the dependency on annotations by learning dense representations from unlabeled data. Recent studies in this direction design various contrastive losses on the feature maps, to yield discriminative features for each pixel in the map. However, pixels in the same map inevitably share semantics to be closer than they actually are, which may affect the discrimination of pixels in the same map and lead to the unfair comparison to pixels in other maps. To address these issues, we propose a separated region-level contrastive learning scheme, namely SepaReg, the core of which is to separate each image into regions and encode each region separately. Specifically, SepaReg comprises two components: a structure-aware image separation (SIS) module and an intra- and inter-organ distillation (IID) module. The SIS is proposed to operate on the image set to rebuild a region set under the guidance of structural information. The inter-organ representation will be learned from this set via typical contrastive losses cross regions. On the other hand, the IID is proposed to tackle the quantity imbalance in the region set as tiny organs may produce fewer regions, by exploiting intra-organ representations. We conducted extensive experiments to evaluate the proposed model on a public dataset and two private datasets. The experimental results demonstrate the effectiveness of the proposed model, consistently achieving better performance than state-of-the-art approaches. Code is available at https://github.com/jcwang123/Separate_CL., Comment: Accepted in AAAI-22 (Oral)

We propose a novel shape-aware relation network for accurate and real-time landmark detection in endoscopic submucosal dissection (ESD) surgery. This task is of great clinical significance but extremely challenging due to bleeding, lighting reflection, and motion blur in the complicated surgical environment. Compared with existing solutions, which either neglect geometric relationships among targeting objects or capture the relationships by using complicated aggregation schemes, the proposed network is capable of achieving satisfactory accuracy while maintaining real-time performance by taking full advantage of the spatial relations among landmarks. We first devise an algorithm to automatically generate relation keypoint heatmaps, which are able to intuitively represent the prior knowledge of spatial relations among landmarks without using any extra manual annotation efforts. We then develop two complementary regularization schemes to progressively incorporate the prior knowledge into the training process. While one scheme introduces pixel-level regularization by multi-task learning, the other integrates global-level regularization by harnessing a newly designed grouped consistency evaluator, which adds relation constraints to the proposed network in an adversarial manner. Both schemes are beneficial to the model in training, and can be readily unloaded in inference to achieve real-time detection. We establish a large in-house dataset of ESD surgery for esophageal cancer to validate the effectiveness of our proposed method. Extensive experimental results demonstrate that our approach outperforms state-of-the-art methods in terms of accuracy and efficiency, achieving better detection results faster. Promising results on two downstream applications further corroborate the great potential of our method in ESD clinical practice.

Skin lesion segmentation from dermoscopy images is of great importance for improving the quantitative analysis of skin cancer. However, the automatic segmentation of melanoma is a very challenging task owing to the large variation of melanoma and ambiguous boundaries of lesion areas. While convolutional neutral networks (CNNs) have achieved remarkable progress in this task, most of existing solutions are still incapable of effectively capturing global dependencies to counteract the inductive bias caused by limited receptive fields. Recently, transformers have been proposed as a promising tool for global context modeling by employing a powerful global attention mechanism, but one of their main shortcomings when applied to segmentation tasks is that they cannot effectively extract sufficient local details to tackle ambiguous boundaries. We propose a novel boundary-aware transformer (BAT) to comprehensively address the challenges of automatic skin lesion segmentation. Specifically, we integrate a new boundary-wise attention gate (BAG) into transformers to enable the whole network to not only effectively model global long-range dependencies via transformers but also, simultaneously, capture more local details by making full use of boundary-wise prior knowledge. Particularly, the auxiliary supervision of BAG is capable of assisting transformers to learn position embedding as it provides much spatial information. We conducted extensive experiments to evaluate the proposed BAT and experiments corroborate its effectiveness, consistently outperforming state-of-the-art methods in two famous datasets.

Performing a real-time and accurate instrument segmentation from videos is of great significance for improving the performance of robotic-assisted surgery. We identify two important clues for surgical instrument perception, including local temporal dependency from adjacent frames and global semantic correlation in long-range duration. However, most existing works perform segmentation purely using visual cues in a single frame. Optical flow is just used to model the motion between only two frames and brings heavy computational cost. We propose a novel dual-memory network (DMNet) to wisely relate both global and local spatio-temporal knowledge to augment the current features, boosting the segmentation performance and retaining the real-time prediction capability. We propose, on the one hand, an efficient local memory by taking the complementary advantages of convolutional LSTM and non-local mechanisms towards the relating reception field. On the other hand, we develop an active global memory to gather the global semantic correlation in long temporal range to current one, in which we gather the most informative frames derived from model uncertainty and frame similarity. We have extensively validated our method on two public benchmark surgical video datasets. Experimental results demonstrate that our method largely outperforms the state-of-the-art works on segmentation accuracy while maintaining a real-time speed.

Convolution on 3D point clouds that generalized from 2D grid-like domains is widely researched yet far from perfect. The standard convolution characterises feature correspondences indistinguishably among 3D points, presenting an intrinsic limitation of poor distinctive feature learning. In this paper, we propose Adaptive Graph Convolution (AdaptConv) which generates adaptive kernels for points according to their dynamically learned features. Compared with using a fixed/isotropic kernel, AdaptConv improves the flexibility of point cloud convolutions, effectively and precisely capturing the diverse relations between points from different semantic parts. Unlike popular attentional weight schemes, the proposed AdaptConv implements the adaptiveness inside the convolution operation instead of simply assigning different weights to the neighboring points. Extensive qualitative and quantitative evaluations show that our method outperforms state-of-the-art point cloud classification and segmentation approaches on several benchmark datasets. Our code is available at https://github.com/hrzhou2/AdaptConv-master., Comment: Camera-ready, to be published in ICCV 2021

Labeling is onerous for crowd counting as it should annotate each individual in crowd images. Recently, several methods have been proposed for semi-supervised crowd counting to reduce the labeling efforts. Given a limited labeling budget, they typically select a few crowd images and densely label all individuals in each of them. Despite the promising results, we argue the None-or-All labeling strategy is suboptimal as the densely labeled individuals in each crowd image usually appear similar while the massive unlabeled crowd images may contain entirely diverse individuals. To this end, we propose to break the labeling chain of previous methods and make the first attempt to reduce spatial labeling redundancy for semi-supervised crowd counting. First, instead of annotating all the regions in each crowd image, we propose to annotate the representative ones only. We analyze the region representativeness from both vertical and horizontal directions, and formulate them as cluster centers of Gaussian Mixture Models. Additionally, to leverage the rich unlabeled regions, we exploit the similarities among individuals in each crowd image to directly supervise the unlabeled regions via feature propagation instead of the error-prone label propagation employed in the previous methods. In this way, we can transfer the original spatial labeling redundancy caused by individual similarities to effective supervision signals on the unlabeled regions. Extensive experiments on the widely-used benchmarks demonstrate that our method can outperform previous best approaches by a large margin., Comment: 8 pages, 6 figures

Single image dehazing is a challenging task, for which the domain shift between synthetic training data and real-world testing images usually leads to degradation of existing methods. To address this issue, we propose a novel image dehazing framework collaborating with unlabeled real data. First, we develop a disentangled image dehazing network (DID-Net), which disentangles the feature representations into three component maps, i.e. the latent haze-free image, the transmission map, and the global atmospheric light estimate, respecting the physical model of a haze process. Our DID-Net predicts the three component maps by progressively integrating features across scales, and refines each map by passing an independent refinement network. Then a disentangled-consistency mean-teacher network (DMT-Net) is employed to collaborate unlabeled real data for boosting single image dehazing. Specifically, we encourage the coarse predictions and refinements of each disentangled component to be consistent between the student and teacher networks by using a consistency loss on unlabeled real data. We make comparison with 13 state-of-the-art dehazing methods on a new collected dataset (Haze4K) and two widely-used dehazing datasets (i.e., SOTS and HazeRD), as well as on real-world hazy images. Experimental results demonstrate that our method has obvious quantitative and qualitative improvements over the existing methods., Comment: 8 pages, 6 figures, ACMMM 2021

Recently the shape-restricted inference has gained popularity in statistical and econometric literature in order to relax the linear or quadratic covariate effect in regression analyses. The typical shape-restricted covariate effect includes monotonic increasing, decreasing, convexity or concavity. In this paper, we introduce the shape-restricted inference to the celebrated Cox regression model (SR-Cox), in which the covariate response is modeled as shape-restricted additive functions. The SR-Cox regression approximates the shape-restricted functions using a spline basis expansion with data driven choice of knots. The underlying minimization of negative log-likelihood function is formulated as a convex optimization problem, which is solved with an active-set optimization algorithm. The highlight of this algorithm is that it eliminates the superfluous knots automatically. When covariate effects include combinations of convex or concave terms with unknown forms and linear terms, the most interesting finding is that SR-Cox produces accurate linear covariate effect estimates which are comparable to the maximum partial likelihood estimates if indeed the forms are known. We conclude that concave or convex SR-Cox models could significantly improve nonlinear covariate response recovery and model goodness of fit., Comment: Updated with new latex template, 33 pages

We present a novel direction-aware feature-level frequency decomposition network for single image deraining. Compared with existing solutions, the proposed network has three compelling characteristics. First, unlike previous algorithms, we propose to perform frequency decomposition at feature-level instead of image-level, allowing both low-frequency maps containing structures and high-frequency maps containing details to be continuously refined during the training procedure. Second, we further establish communication channels between low-frequency maps and high-frequency maps to interactively capture structures from high-frequency maps and add them back to low-frequency maps and, simultaneously, extract details from low-frequency maps and send them back to high-frequency maps, thereby removing rain streaks while preserving more delicate features in the input image. Third, different from existing algorithms using convolutional filters consistent in all directions, we propose a direction-aware filter to capture the direction of rain streaks in order to more effectively and thoroughly purge the input images of rain streaks. We extensively evaluate the proposed approach in three representative datasets and experimental results corroborate our approach consistently outperforms state-of-the-art deraining algorithms.