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Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immune cells. Cardiac damage could be prevented by blocking this pathway.

Ettringite binder is widely used in mortars for technical applications such as patching mortars, self-leveling screeds, repair mortars thanks to their fast hardening ability and high early strength. However, depending on the amount and types of raw materials used in the composition, the properties of these types of binder have different behaviors at early-age and at long term. In this work, the influence of the nature and dosage of calcium sulfate in ettringite binder on the long-term strength of mortar in different curing conditions was determined. The results showed that the increase of calcium sulfate content in ettringite binder from 10–25 % improves the strength of mortars regardless of the calcium sulfate nature. In all curing conditions (endogenous, drying, outdoor), the strength of ettringite mortars with anhydrite is smaller than that of mortars containing hemihydrate. There is no major difference in the porosity of the mortars in different types of curing conditions before 28 days. However, after 28 days the porosity of mortar in drying condition is about 2–3 % higher than that of the mortars in endogenous and outdoor conditions.

This article explores how time and space influence the decision-making process (DMP) that hijabis (Muslim women who wear a headscarf or hijab) undergo when deciding whether to disclose their hijab to their manager. Drawing on 40 interviews with hijabis, whose identity is a source of significant stigmatization and discrimination in France, we show that, rather than being constrained by time and space, hijabis take advantage of these elements to foster their own agency. Three contributions to the literature emerge from our findings. First, the decision-making process can be broken down into three phases: conceptualization, planning, and actualization. Over the course of these three phases, specific steps are taken depending on whether or not hijabis wish to include their manager in their DMP. This is how hijabis take control of their disclosure decision, which must take the manager's reaction into account. Second, we demonstrate that hijabis focus on the temporal dimension when selecting the most appropriate point at which to share their decision. For the spatial dimension, we introduce the concept of transition space to convey the way hijabis construct a secure environment in which to make their decision. This space has four key characteristics: It is secluded and offers protection, it is flexible, it is essential, and it is a space of psychological distress. Finally, we show that identity management (IM) decisions incur material costs. [ABSTRACT FROM AUTHOR]

Objective. To compare the prevalence and trajectories of risky health behaviors in sexual minority (SM; lesbian/gay/bisexual/questioning/asexual) versus heterosexual undergraduates across their first year of post-secondary. Participants. First-year undergraduates (N = 704, Mage=17.97 years, 24% SM) from a midsized Canadian university. Methods. Students completed monthly (September-April) online questionnaires assessing substance use (binge drinking, tobacco, cannabis, illicit drug use) and disordered eating (binge eating, fasting, purging). Results. At the outset of the academic year, SM students endorsed more frequent cannabis use, illicit drug use, fasting, and binge eating, but less frequent tobacco use, versus heterosexual students. Over the year, SM students' binge drinking frequency declined less than that of heterosexual students, but their illicit drug use decreased while that of their heterosexual peers increased, and all students reported declining disordered eating frequency. Conclusions. Campus wellness initiatives for SM students should offer prevention and harm-reduction strategies prior to or shortly after their arrival on campus. [ABSTRACT FROM AUTHOR]

Disordered eating refers to a range of eating behaviours and attitudes towards weight and food that can negatively influence physical and psychosocial well-being. The menopausal transition could be a vulnerable period for disordered eating due to major hormonal fluctuations, menopausal symptoms, common body composition shifts, and an increased risk of psychological challenges. This systematic review aimed to summarize evidence on the associations between the menopausal transition and disordered eating. Records published before October 2023 were identified through MEDLINE, PsycINFO, Scopus, Embase, and CINAHL. Studies investigating associations between menopausal status, menopausal symptoms, or reproductive hormone levels, and disordered eating during the menopausal transition were sought. A total of 1301 non-duplicate records were screened, with 10 studies deemed eligible for inclusion. Most included studies used a cross-sectional design (n = 9). Findings include potentially higher levels of binge eating during the perimenopausal stage, whereas restrictive eating behaviours appeared more common during postmenopause compared to premenopause. Both studies investigating menopausal symptoms found strong positive associations with disordered eating. Nonetheless, findings are equivocal with contrasting results and limited methodological quality across studies. Further research is needed to verify these findings and better assist health professionals in supporting healthy eating behaviours in menopausal women during this complex transition. (PROSPERO ID: CRD42021290736) [ABSTRACT FROM AUTHOR]

This open trial evaluated the feasibility, acceptability, and preliminary efficacy of Bootcamp for ADHD (BC-ADHD), a novel, four-session, group intervention designed to prepare caregivers as informed consumers to engage in multimodal evidence-based treatments (EBTs) for ADHD. Participants were 59 primary caregivers (85% biologic mothers) of children recently diagnosed with ADHD within a co-located, subspecialty pediatric clinic (ages 5–11; 73% male). Results indicated BC-ADHD was feasible to deliver, as evidenced by high levels of program usability (i.e. content and process fidelity), and caregiver behavioral engagement (M attendance = 88%; M homework adherence = 2.95 homework, SD = 1.15, 0–4 range). Families were also very satisfied (M = 6.06, 1–7 range). At post-treatment, BC-ADHD resulted in increases in caregiver empowerment and acceptability of behavioral treatment and reductions in concerns about both behavioral (adverse effects and feasibility) and medication (adverse effects) treatments (absolute Cohen's d = 0.27 to 0.35). At 6-month follow-up, effects were sustained for increases in caregiver empowerment and for reductions in concerns about both behavioral and medication treatments (absolute ds = 0.36 to 0.40). Sleeper effects were observed for increased medication acceptability and decreased affiliate stigma (absolute ds = 0.26 to 0.29). Child impairment was also reduced at follow-up (d = -0.58). The percentage of caregivers who initiated behavior therapy (Kendall's w = 0.63) or medication (Kendall's w = 0.15) increased from baseline to 6-month follow-up. These findings provide initial support for BC-ADHD as a promising engagement program to foster positive caregiver attitudes and initiation of EBTs. [ABSTRACT FROM AUTHOR]

In this study, we developed stabilized astaxanthin (AX) nanoparticles (sNP/AX) to improve the physicochemical properties, oral bioavailability, and hepatoprotection of AX. A flash nanoprecipitation technique was used with a multi-inlet vortex mixer to prepare the sNP/AX. Vitamins E (VE) and C (VC) were used as co-stabilizers with poloxamer 407 as a stabilizer to inhibit the oxidative degradation of AX during sNP/AX formation and storage. VC stabilized AX in the aqueous phase during the preparation, whereas VE markedly improved the storage stability of sNP/AX, as evidenced by the AX contents remaining at 94 and 81% after 12 weeks of storage at 4 °C and 25 °C, respectively. The mean sNP/AX diameter was 215 nm, which resulted in higher AX release properties than those of crystalline AX. Rats, orally administered sNP/AX (33.2 mg AX/kg), exhibited higher systemic exposure to AX, whereas oral absorption in the crystalline AX group was negligible. In the rat hepatic injury model, oral pretreatment with sNP/AX (33.2 mg AX/kg) markedly attenuated hepatic damage, as shown by the histopathological analysis and reduced levels of plasma biomarkers for hepatic injury. These findings suggest that strategically including antioxidative additives in the sNP/AX has the potential to improve the physicochemical and nutraceutical properties of AX.

The aim of the proposed scoping review is to describe and summarize studies assessing the associations between diet-related variables and depression in peri- and post-menopausal women. Studies examining the associations between diet-related variables and mental health indicators in women undergoing menopausal transition or in the post-menopausal period will be systematically retrieved via Medline, EMBASE, PsycINFO, Web of Science, and Scopus databases. All articles identified through the database searches will be imported into Covidence. Following the removal of duplicates, two authors will independently perform title and abstract screening, as well as full-text assessment against eligibility criteria. Data will be extracted using tables developed for observational and experimental studies. The methodological quality of randomized trials, cohort and cross-sectional studies, and case–control studies, will be assessed using the Cochrane risk-of-bias (RoB-2) tool, the NHLBI Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies, and the NHLBI Quality Assessment Tool for Case–Control studies, respectively. Data extraction tables will be used to produce two tables summarizing the main characteristics and findings of the studies included in the review. In the proposed review, we will systematically identify and summarize the currently available evidence on the association between diet-related variables and depression in peri- and post-menopausal women. To our knowledge, this is the first review focusing on this subgroup of the population. Protocol registration: osf.io/b89r6.

This article offers a rationale for research and engagement on conceptions of ‘community’ in the twenty-first century in the context of changing conceptions of relationality through the impact of secularisation, social media, and online gaming. It highlights the growing concerns and healthcare outcomes of isolation in the context of shifting perceptions of ‘community’ as the basis for a re-examination of the value of ‘covenant’ as ‘communities of purpose’ in our interdependent world. In so doing, it proposes that covenant communities offer a route through which fundamental relationalities which engender belonging, security, and personal value can be restored at local, national or even trans-national levels.

Background The goal of this study was to determine whether an awake prone position (aPP) reduces the global inhomogeneity (GI) index of ventilation measured by electrical impedance tomography (EIT) in COVID-19 patients with acute respiratory failure (ARF). Methods This prospective crossover study included COVID-19 patients with COVID-19 and ARF defined by arterial oxygen tension:inspiratory oxygen fraction (PaO2:FIO2) of 100–300 mmHg. After baseline evaluation and 30-min EIT recording in the supine position (SP), patients were randomised into one of two sequences: SP-aPP or aPP-SP. At the end of each 2-h step, oxygenation, respiratory rate, Borg scale and 30-min EIT were recorded. Results 10 patients were randomised in each group. The GI index did not change in the SP-aPP group (baseline 74±20%, end of SP 78±23% and end of aPP 72±20%, p=0.85) or in the aPP-SP group (baseline 59±14%, end of aPP 59±15% and end of SP 54±13%, p=0.67). In the whole cohort, PaO2:FIO2 increased from 133±44 mmHg at baseline to 183±66 mmHg in aPP (p=0.003) and decreased to 129±49 mmHg in SP (p=0.03). Conclusion In spontaneously breathing nonintubated COVID-19 patients with ARF, aPP was not associated with a decrease of lung ventilation inhomogeneity assessed by EIT, despite an improvement in oxygenation.