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101. Body size and weight change over adulthood and risk of breast cancer by menopausal and hormone receptor status : a pooled analysis of 20 prospective cohort studies

Author

van den Brandt, Piet A, Ziegler, Regina G, Wang, Molin, Hou, Tao, Li, Ruifeng, Adami, Hans-Olov, Agnoli, Claudia, Bernstein, Leslie, Buring, Julie E, Chen, Yu, Connor, Avonne E, Eliassen, A Heather, Genkinger, Jeanine M, Gierach, Gretchen, Giles, Graham G, Goodman, Gary G, Håkansson, Niclas, Krogh, Vittorio, Le Marchand, Loic, Lee, I-Min, Liao, Linda M, Martinez, M Elena, Miller, Anthony B, Milne, Roger L, Neuhouser, Marian L, Patel, Alpa V, Prizment, Anna, Robien, Kim, Rohan, Thomas E, Sawada, Norie, Schouten, Leo J, Sinha, Rashmi, Stolzenberg-Solomon, Rachael Z, Teras, Lauren R, Tsugane, Shoichiro, Visvanathan, Kala, Weiderpass, Elisabete, White, Kami K, Willett, Walter C, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Smith-Warner, Stephanie A, van den Brandt, Piet A, Ziegler, Regina G, Wang, Molin, Hou, Tao, Li, Ruifeng, Adami, Hans-Olov, Agnoli, Claudia, Bernstein, Leslie, Buring, Julie E, Chen, Yu, Connor, Avonne E, Eliassen, A Heather, Genkinger, Jeanine M, Gierach, Gretchen, Giles, Graham G, Goodman, Gary G, Håkansson, Niclas, Krogh, Vittorio, Le Marchand, Loic, Lee, I-Min, Liao, Linda M, Martinez, M Elena, Miller, Anthony B, Milne, Roger L, Neuhouser, Marian L, Patel, Alpa V, Prizment, Anna, Robien, Kim, Rohan, Thomas E, Sawada, Norie, Schouten, Leo J, Sinha, Rashmi, Stolzenberg-Solomon, Rachael Z, Teras, Lauren R, Tsugane, Shoichiro, Visvanathan, Kala, Weiderpass, Elisabete, White, Kami K, Willett, Walter C, Wolk, Alicja, Zeleniuch-Jacquotte, Anne, and Smith-Warner, Stephanie A

Abstract

Associations between anthropometric factors and breast cancer (BC) risk have varied inconsistently by estrogen and/or progesterone receptor (ER/PR) status. Associations between prediagnostic anthropometric factors and risk of premenopausal and postmenopausal BC overall and ER/PR status subtypes were investigated in a pooled analysis of 20 prospective cohorts, including 36,297 BC cases among 1,061,915 women, using multivariable Cox regression analyses, controlling for reproductive factors, diet and other risk factors. We estimated dose-response relationships and tested for nonlinear associations using restricted cubic splines. Height showed positive, linear associations for premenopausal and postmenopausal BC risk (6-7% RR increase per 5 cm increment), with stronger associations for receptor-positive subtypes. Body mass index (BMI) at cohort baseline was strongly inversely associated with premenopausal BC risk, and strongly positively-and nonlinearly-associated with postmenopausal BC (especially among women who never used hormone replacement therapy). This was primarily observed for receptor-positive subtypes. Early adult BMI (at 18-20 years) showed inverse, linear associations for premenopausal and postmenopausal BC risk (21% and 11% RR decrease per 5 kg/m2, respectively) with stronger associations for receptor-negative subtypes. Adult weight gain since 18-20 years was positively associated with postmenopausal BC risk, stronger for receptor-positive subtypes, and among women who were leaner in early adulthood. Women heavier in early adulthood generally had reduced premenopausal BC risk, independent of later weight gain. Positive associations between height, baseline (adult) BMI, adult weight gain and postmenopausal BC risk were substantially stronger for hormone receptor-positive versus negative subtypes. Premenopausal BC risk was positively associated with height, but inversely with baseline BMI and weight gain (mostly in receptor-positive subtypes). Inverse associ

Published
2021
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102. Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium

Author

Jordan, Susan J., Jordan, Susan J., Na, Renhua, Weiderpass, Elisabete, Adami, Hans-Olov, Anderson, Kristin E., van den Brandt, Piet A., Brinton, Louise A., Chen, Chu, Cook, Linda S., Doherty, Jennifer A., Du, Mengmeng, Friedenreich, Christine M., Gierach, Gretchen L., Goodman, Marc T., Krogh, Vittorio, Levi, Fabio, Lu, Lingeng, Miller, Anthony B., McCann, Susan E., Moysich, Kirsten B., Negri, Eva, Olson, Sara H., Petruzella, Stacey, Palmer, Julie R., Parazzini, Fabio, Pike, Malcolm C., Prizment, Anna E., Rebbeck, Timothy R., Reynolds, Peggy, Ricceri, Fulvio, Risch, Harvey A., Rohan, Thomas E., Sacerdote, Carlotta, Schouten, Leo J., Serraino, Diego, Setiawan, Veronica W., Shu, Xiao-Ou, Sponholtz, Todd R., Spurdle, Amanda B., Stolzenberg-Solomon, Rachael Z., Trabert, Britton, Wentzensen, Nicolas, Wilkens, Lynne R., Wise, Lauren A., Yu, Herbert, La Vecchia, Carlo, De Vivo, Immaculata, Xu, Wanghong, Zeleniuch-Jacquotte, Anne, Webb, Penelope M., Jordan, Susan J., Jordan, Susan J., Na, Renhua, Weiderpass, Elisabete, Adami, Hans-Olov, Anderson, Kristin E., van den Brandt, Piet A., Brinton, Louise A., Chen, Chu, Cook, Linda S., Doherty, Jennifer A., Du, Mengmeng, Friedenreich, Christine M., Gierach, Gretchen L., Goodman, Marc T., Krogh, Vittorio, Levi, Fabio, Lu, Lingeng, Miller, Anthony B., McCann, Susan E., Moysich, Kirsten B., Negri, Eva, Olson, Sara H., Petruzella, Stacey, Palmer, Julie R., Parazzini, Fabio, Pike, Malcolm C., Prizment, Anna E., Rebbeck, Timothy R., Reynolds, Peggy, Ricceri, Fulvio, Risch, Harvey A., Rohan, Thomas E., Sacerdote, Carlotta, Schouten, Leo J., Serraino, Diego, Setiawan, Veronica W., Shu, Xiao-Ou, Sponholtz, Todd R., Spurdle, Amanda B., Stolzenberg-Solomon, Rachael Z., Trabert, Britton, Wentzensen, Nicolas, Wilkens, Lynne R., Wise, Lauren A., Yu, Herbert, La Vecchia, Carlo, De Vivo, Immaculata, Xu, Wanghong, Zeleniuch-Jacquotte, Anne, and Webb, Penelope M.

Abstract

A full-term pregnancy is associated with reduced endometrial cancer risk; however, whether the effect of additional pregnancies is independent of age at last pregnancy is unknown. The associations between other pregnancy-related factors and endometrial cancer risk are less clear. We pooled individual participant data from 11 cohort and 19 case-control studies participating in the Epidemiology of Endometrial Cancer Consortium (E2C2) including 16 986 women with endometrial cancer and 39 538 control women. We used one- and two-stage meta-analytic approaches to estimate pooled odds ratios (ORs) for the association between exposures and endometrial cancer risk. Ever having a full-term pregnancy was associated with a 41% reduction in risk of endometrial cancer compared to never having a full-term pregnancy (OR = 0.59, 95% confidence interval [CI] 0.56-0.63). The risk reduction appeared the greatest for the first full-term pregnancy (OR = 0.78, 95% CI 0.72-0.84), with a further similar to 15% reduction per pregnancy up to eight pregnancies (OR = 0.20, 95% CI 0.14-0.28) that was independent of age at last full-term pregnancy. Incomplete pregnancy was also associated with decreased endometrial cancer risk (7%-9% reduction per pregnancy). Twin births appeared to have the same effect as singleton pregnancies. Our pooled analysis shows that, while the magnitude of the risk reduction is greater for a full-term pregnancy than an incomplete pregnancy, each additional pregnancy is associated with further reduction in endometrial cancer risk, independent of age at last full-term pregnancy. These results suggest that the very high progesterone level in the last trimester of pregnancy is not the sole explanation for the protective effect of pregnancy.

Published
2021

103. Smoking Behavior and Prognosis after Colorectal Cancer Diagnosis : A Pooled Analysis of 11 Studies

Author

Alwers, Elizabeth, Carr, Prudence R., Banbury, Barbara, Walter, Viola, Chang-Claude, Jenny, Jansen, Lina, Drew, David A., Giovannucci, Edward, Nan, Hongmei, Berndt, Sonja I., Huang, Wen-Yi, Prizment, Anna, Hayes, Richard B., Sakoda, Lori C., White, Emily, Labadie, Julia, Slattery, Martha, Schoen, Robert E., Diergaarde, Brenda, van Guelpen, Bethany, Campbell, Peter T., Peters, Ulrike, Chan, Andrew T., Newcomb, Polly A., Hoffmeister, Michael, Brenner, Hermann, Alwers, Elizabeth, Carr, Prudence R., Banbury, Barbara, Walter, Viola, Chang-Claude, Jenny, Jansen, Lina, Drew, David A., Giovannucci, Edward, Nan, Hongmei, Berndt, Sonja I., Huang, Wen-Yi, Prizment, Anna, Hayes, Richard B., Sakoda, Lori C., White, Emily, Labadie, Julia, Slattery, Martha, Schoen, Robert E., Diergaarde, Brenda, van Guelpen, Bethany, Campbell, Peter T., Peters, Ulrike, Chan, Andrew T., Newcomb, Polly A., Hoffmeister, Michael, and Brenner, Hermann

Abstract

Background: Smoking has been associated with colorectal cancer (CRC) incidence and mortality in previous studies, but current evidence on smoking in association with survival after CRC diagnosis is limited. Methods: We pooled data from 12 345 patients with stage I-IV CRC from 11 epidemiologic studies in the International Survival Analysis in Colorectal Cancer Consortium. Cox proportional hazards regression models were used to evaluate the associations of prediagnostic smoking behavior with overall, CRC-specific, and non-CRC-specific survival. Results: Among 12 345 patients with CRC, 4379 (35.5%) died (2515 from CRC) over a median follow-up time of 7.5years. Smoking was strongly associated with worse survival in stage I-III patients, whereas no associa-tion was observed among stage IV patients. Among stage I-III patients, clear dose-response relationships with all survival outcomes were seen for current smokers. For example, current smokers with 40 or more pack-years had statistically significantly worse over-all, CRC-specific, and non-CRC-specific survival compared with never smokers (hazard ratio [HR] 1/41.94, 95% confidence interval [CI] 1/41.68 to 2.25; HR = 1.41, 95% CI = 1.12 to 1.78; and HR = 2.67, 95% CI = 2.19 to 3.26, respectively). Similar associations with all sur-vival outcomes were observed for former smokers who had quit for less than 10years, but only a weak association with non-CRC-specific survival was seen among former smokers who had quit for more than 10years. Conclusions: This large consortium of CRC patient studies provides compelling evidence that smoking is strongly associated with worse survival of stage I-III CRC patients in a clear dose-response manner. The detrimental effect of smoking was primarily related to noncolorectal cancer events, but current heavy smoking also showed an association with CRC-specific survival.

Published
2021
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104. Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status : a pooled analysis of 21 cohort studies

Author

Wu, You, Huang, Ruyi, Wang, Molin, Bernstein, Leslie, Bethea, Traci N., Chen, Chu, Chen, Yu, Eliassen, A. Heather, Freedman, Neal D., Gaudet, Mia M., Gierach, Gretchen L., Giles, Graham G., Krogh, Vittorio, Larsson, Susanna C., Liao, Linda M., McCullough, Marjorie L., Miller, Anthony B., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., Palmer, Julie R., Prizment, Anna, Reynolds, Peggy, Robien, Kim, Rohan, Thomas E., Sandin, Sven, Sawada, Norie, Sieri, Sabina, Sinha, Rashmi, Stolzenberg-Solomon, Rachael Z., Tsugane, Shoichiro, van den Brandt, Piet A., Visvanathan, Kala, Weiderpass, Elisabete, Wilkens, Lynne R., Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Ziegler, Regina G., Smith-Warner, Stephanie A., Wu, You, Huang, Ruyi, Wang, Molin, Bernstein, Leslie, Bethea, Traci N., Chen, Chu, Chen, Yu, Eliassen, A. Heather, Freedman, Neal D., Gaudet, Mia M., Gierach, Gretchen L., Giles, Graham G., Krogh, Vittorio, Larsson, Susanna C., Liao, Linda M., McCullough, Marjorie L., Miller, Anthony B., Milne, Roger L., Monroe, Kristine R., Neuhouser, Marian L., Palmer, Julie R., Prizment, Anna, Reynolds, Peggy, Robien, Kim, Rohan, Thomas E., Sandin, Sven, Sawada, Norie, Sieri, Sabina, Sinha, Rashmi, Stolzenberg-Solomon, Rachael Z., Tsugane, Shoichiro, van den Brandt, Piet A., Visvanathan, Kala, Weiderpass, Elisabete, Wilkens, Lynne R., Willett, Walter C., Wolk, Alicja, Zeleniuch-Jacquotte, Anne, Ziegler, Regina G., and Smith-Warner, Stephanie A.

Abstract

Background: Epidemiologic studies examining the relations between dairy product and calcium intakes and breast cancer have been inconclusive, especially for tumor subtypes. Objective: To evaluate the associations between intakes of specific dairy products and calcium and risk of breast cancer overall and for subtypes defined by estrogen receptor (ER) status. Method: We pooled the individual-level data of over 1 million women who were followed for a maximum of 8-20 years across studies. Associations were evaluated for dairy product and calcium intakes and risk of incident invasive breast cancer overall (n = 37,861 cases) and by subtypes defined by ER status. Study-specific multivariable hazard ratios (HRs) were estimated and then combined using random-effects models. Results: Overall, no clear association was observed between the consumption of specific dairy foods, dietary (from foods only) calcium, and total (from foods and supplements) calcium, and risk of overall breast cancer. Although each dairy product showed a null or very weak inverse association with risk of overall breast cancer (P, test for trend >0.05 for all), differences by ER status were suggested for yogurt and cottage/ricotta cheese with associations observed for ER-negative tumors only (pooled HR = 0.90, 95% CI: 0.83, 0.98 comparing >= 60 g/d with <1 g/d of yogurt and 0.85, 95% CI: 0.76, 0.95 comparing >= 25 g/d with <1 g/d of cottage/ricotta cheese). Dietary calcium intake was only weakly associated with breast cancer risk (pooled HR = 0.98, 95% CI: 0.97, 0.99 per 350 mg/d). Conclusion: Our study shows that adult dairy or calcium consumption is unlikely to associate with a higher risk of breast cancer and that higher yogurt and cottage/ricotta cheese intakes were inversely associated with the risk of ER-negative breast cancer, a less hormonally dependent subtype with poor prognosis. Future studies on fermented dairy products, earlier life exposures, ER-negative breast cancer, and di

Published
2021
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105. Association of the Age at Menarche with Site-Specific Cancer Risks in Pooled Data from Nine Cohorts

Author

Fuhrman, Barbara J, Moore, Steven C, Byrne, Celia, Makhoul, Issam, Kitahara, Cari M, Berrington de González, Amy, Linet, Martha S, Weiderpass, Elisabete, Adami, Hans-Olov, Freedman, Neal D, Liao, Linda M, Matthews, Charles E, Stolzenberg-Solomon, Rachael Z, Gaudet, Mia M, Patel, Alpa V, Lee, I-Min, Buring, Julie E, Wolk, Alicja, Larsson, Susanna C., Prizment, Anna E, Robien, Kim, Spriggs, Michael, Check, David P, Murphy, Neil, Gunter, Marc J, Van Dusen, Harold L, Ziegler, Regina G, Hoover, Robert N, Fuhrman, Barbara J, Moore, Steven C, Byrne, Celia, Makhoul, Issam, Kitahara, Cari M, Berrington de González, Amy, Linet, Martha S, Weiderpass, Elisabete, Adami, Hans-Olov, Freedman, Neal D, Liao, Linda M, Matthews, Charles E, Stolzenberg-Solomon, Rachael Z, Gaudet, Mia M, Patel, Alpa V, Lee, I-Min, Buring, Julie E, Wolk, Alicja, Larsson, Susanna C., Prizment, Anna E, Robien, Kim, Spriggs, Michael, Check, David P, Murphy, Neil, Gunter, Marc J, Van Dusen, Harold L, Ziegler, Regina G, and Hoover, Robert N

Abstract

The average age at menarche declined in European and U.S. populations during the 19th and 20th centuries. The timing of pubertal events may have broad implications for chronic disease risks in aging women. Here we tested for associations of recalled menarcheal age with risks of 19 cancers in 536,450 women [median age, 60 years (range, 31-39 years)] in nine prospective U.S. and European cohorts that enrolled participants from 1981 to 1998. Cox regression estimated multivariable-adjusted HRs and 95% confidence intervals (CI) for associations of the age at menarche with risk of each cancer in each cohort and random-effects meta-analysis was used to generate summary estimates for each cancer. Over a median 10 years of follow-up, 60,968 women were diagnosed with a first primary incident cancer. Inverse linear associations were observed for seven of 19 cancers studied. Each additional year in the age at menarche was associated with reduced risks of endometrial cancer (HR = 0.91; 95% CI, 0.89-0.94), liver cancer (HR = 0.92; 95% CI, 0.85-0.99), melanoma (HR = 0.95; 95% CI, 0.93-0.98), bladder cancer (HR = 0.96; 95% CI, 0.93-0.99), and cancers of the colon (HR = 0.97; 95% CI, 0.96-0.99), lung (HR = 0.98; 95% CI, 0.96-0.99), and breast (HR = 0.98; 95% CI, 0.93-0.99). All but one of these associations remained statistically significant following adjustment for baseline body mass index. Similarities in the observed associations between menarche and seven cancers suggest shared underlying causes rooted early in life. We propose as a testable hypothesis that early exposure to sex hormones increases mid-life cancer risks by altering functional capacities of stem cells with roles in systemic energy balance and tissue homeostasis. SIGNIFICANCE: Age at menarche is associated with risk for seven cancers in middle-aged women, and understanding the shared underlying causal pathways across these cancers may suggest new avenues for cancer prevention.

Published
2021
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109. Association of the Age at Menarche with Site-Specific Cancer Risks in Pooled Data from Nine Cohorts

Author

Fuhrman, Barbara J., primary, Moore, Steven C., additional, Byrne, Celia, additional, Makhoul, Issam, additional, Kitahara, Cari M., additional, Berrington de González, Amy, additional, Linet, Martha S., additional, Weiderpass, Elisabete, additional, Adami, Hans-Olov, additional, Freedman, Neal D., additional, Liao, Linda M., additional, Matthews, Charles E., additional, Stolzenberg-Solomon, Rachael Z., additional, Gaudet, Mia M., additional, Patel, Alpa V., additional, Lee, I-Min, additional, Buring, Julie E., additional, Wolk, Alicja, additional, Larsson, Susanna C., additional, Prizment, Anna E., additional, Robien, Kim, additional, Spriggs, Michael, additional, Check, David P., additional, Murphy, Neil, additional, Gunter, Marc J., additional, Van Dusen, Harold L., additional, Ziegler, Regina G., additional, and Hoover, Robert N., additional

Published
2021
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112. Salad/Vegetable Versus Red/Processed Meat-Dominant Diet And Outcomes of Hematopoietic Cell Transplantation

Author

Haugen, Katie, primary, Hoeschen, Andrea, additional, Kennedy, Jessica, additional, Hillman, Benjamin, additional, Turner, Gavin, additional, Smith, Madeline, additional, Shields-Cutler, Robin, additional, Wilson, Jessica, additional, Cao, Qing, additional, Robien, Kim, additional, Prizment, Anna, additional, Jurdi, Najla El, additional, MacMillan, Margaret L., additional, Weisdorf, Daniel J., additional, Betts, Brian Christopher, additional, Arora, Mukta, additional, Blazar, Bruce R., additional, Rashidi, Armin, additional, Brunstein, Claudio G., additional, Khoruts, Alexander, additional, Knights, Daniel, additional, and Holtan, Shernan, additional

Published
2021
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118. Associations of Novel Lifestyle- and Whole Foods-Based Inflammation Scores with Incident Colorectal Cancer Among Women.

Author

Gao, Yasheen, Byrd, Doratha A., Prizment, Anna, Lazovich, DeAnn, and Bostick, Roberd M.

Subjects
LIFESTYLES, FOOD habits, BIOMARKERS, CONFIDENCE intervals, INFLAMMATION, MULTIVARIATE analysis, REGRESSION analysis, COLORECTAL cancer, DESCRIPTIVE statistics, DATA analysis software, WOMEN'S health, PROPORTIONAL hazards models
Abstract

Chronic inflammation, associated with lifestyle and dietary factors, may contribute to colorectal carcinogenesis. To address this, we investigated associations of previously validated, inflammation biomarker panel-weighted, novel, 4-component lifestyle (LIS) and 19-component predominately whole foods-based dietary (DIS) inflammation scores with incident colorectal cancer (CRC) in the prospective Iowa Women's Health Study (IWHS; 1986–2012; n = 34,254, of whom 1,632 developed CRC). We applied the published scores' components' weights, summed the weighted components to constitute the scores (higher scores reflect a higher balance of pro-inflammatory exposures), and investigated LIS- and DIS-CRC associations using multivariable Cox proportional hazards regression. The multivariable-adjusted hazards ratios (HR) and their 95% confidence intervals (CI) for CRC among participants in the highest relative to the lowest LIS and DIS quintiles were 1.47 (1.26, 1.72; Ptrend < 0.01) and 1.07 (0.91, 1.25; Ptrend = 0.22), respectively. The corresponding findings for distal colon cancers were HR 1.78 (1.29, 2.47) and HR 1.34 (0.98, 1.84), respectively. Among those in the highest relative to the lowest joint LIS/DIS quintile, the HR for CRC was 1.60 (95% CI 1.30, 1.98). Our results suggest that a more pro-inflammatory lifestyle, alone and jointly with a more pro-inflammatory diet, may be associated with higher CRC risk. [ABSTRACT FROM AUTHOR]

Published
2022
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122. Associations between tissue‐based CD3+ T‐lymphocyte count and colorectal cancer survival in a prospective cohort of older women

Author

Oyenuga, Mosunmoluwa, primary, Vierkant, Robert A., additional, Lynch, Charles F., additional, Pengo, Thomas, additional, Tillmans, Lori S., additional, Cerhan, James R., additional, Church, Timothy R., additional, Lazovich, DeAnn, additional, Anderson, Kristin E., additional, Limburg, Paul J., additional, and Prizment, Anna E., additional

Published
2020
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123. Pregnancy outcomes and risk of endometrial cancer: A pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium

Author

Jordan, Susan J., primary, Na, Renhua, additional, Weiderpass, Elisabete, additional, Adami, Hans‐Olov, additional, Anderson, Kristin E., additional, Brandt, Piet A., additional, Brinton, Louise A., additional, Chen, Chu, additional, Cook, Linda S., additional, Doherty, Jennifer A., additional, Du, Mengmeng, additional, Friedenreich, Christine M., additional, Gierach, Gretchen L., additional, Goodman, Marc T., additional, Krogh, Vittorio, additional, Levi, Fabio, additional, Lu, Lingeng, additional, Miller, Anthony B., additional, McCann, Susan E., additional, Moysich, Kirsten B., additional, Negri, Eva, additional, Olson, Sara H., additional, Petruzella, Stacey, additional, Palmer, Julie R., additional, Parazzini, Fabio, additional, Pike, Malcolm C., additional, Prizment, Anna E., additional, Rebbeck, Timothy R., additional, Reynolds, Peggy, additional, Ricceri, Fulvio, additional, Risch, Harvey A., additional, Rohan, Thomas E., additional, Sacerdote, Carlotta, additional, Schouten, Leo J., additional, Serraino, Diego, additional, Setiawan, Veronica W., additional, Shu, Xiao‐Ou, additional, Sponholtz, Todd R., additional, Spurdle, Amanda B., additional, Stolzenberg‐Solomon, Rachael Z., additional, Trabert, Britton, additional, Wentzensen, Nicolas, additional, Wilkens, Lynne R., additional, Wise, Lauren A., additional, Yu, Herbert, additional, La Vecchia, Carlo, additional, De Vivo, Immaculata, additional, Xu, Wanghong, additional, Zeleniuch‐Jacquotte, Anne, additional, and Webb, Penelope M., additional

Published
2020
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124. Body size and weight change over adulthood and risk of breast cancer by menopausal and hormone receptor status: a pooled analysis of 20 prospective cohort studies

Author

van den Brandt, Piet A., primary, Ziegler, Regina G., additional, Wang, Molin, additional, Hou, Tao, additional, Li, Ruifeng, additional, Adami, Hans-Olov, additional, Agnoli, Claudia, additional, Bernstein, Leslie, additional, Buring, Julie E., additional, Chen, Yu, additional, Connor, Avonne E., additional, Eliassen, A. Heather, additional, Genkinger, Jeanine M., additional, Gierach, Gretchen, additional, Giles, Graham G., additional, Goodman, Gary G., additional, Håkansson, Niclas, additional, Krogh, Vittorio, additional, Le Marchand, Loic, additional, Lee, I-Min, additional, Liao, Linda M., additional, Martinez, M. Elena, additional, Miller, Anthony B., additional, Milne, Roger L., additional, Neuhouser, Marian L., additional, Patel, Alpa V., additional, Prizment, Anna, additional, Robien, Kim, additional, Rohan, Thomas E., additional, Sawada, Norie, additional, Schouten, Leo J., additional, Sinha, Rashmi, additional, Stolzenberg-Solomon, Rachael Z., additional, Teras, Lauren R., additional, Tsugane, Shoichiro, additional, Visvanathan, Kala, additional, Weiderpass, Elisabete, additional, White, Kami K., additional, Willett, Walter C., additional, Wolk, Alicja, additional, Zeleniuch-Jacquotte, Anne, additional, and Smith-Warner, Stephanie A., additional

Published
2020
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127. Abstract A25: Collecting gut microbiome in the 10,000 Families Study

Author

Prizment, Anna, primary, Gabrielson, Deanna, additional, Lazovich, DeAnn, additional, Minnerath, Sharon, additional, Nelson, Heather H., additional, Poynter, Jenny N., additional, Reilly, Cavan, additional, Roesler, Michelle, additional, Spector, Logan G., additional, and Thyagarajan, Bharat, additional

Published
2020
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128. Abstract A26: Pilot trial to examine the effect of ginger on the gut microbiome: The Minnesota Cancer Clinical Trials Network

Author

Prizment, Anna, primary, Church, Timothy R., additional, Hatsukami, Dorothy, additional, Madoff, Robert, additional, Staley, Christopher, additional, Straka, Robert J., additional, Iwan, Allison, additional, Stromberg, Jenn, additional, Wen, Ya-Feng, additional, Stibbe, Cheryl, additional, and Rahne, Marie, additional

Published
2020
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131. Randomised clinical study: oral aspirin 325 mg daily vs placebo alters gut microbial composition and bacterial taxa associated with colorectal cancer risk

Author

Prizment, Anna E., primary, Staley, Christopher, additional, Onyeaghala, Guillaume C., additional, Vivek, Sithara, additional, Thyagarajan, Bharat, additional, Straka, Robert J., additional, Demmer, Ryan T., additional, Knights, Dan, additional, Meyer, Katie A., additional, Shaukat, Aasma, additional, Sadowsky, Michael J., additional, and Church, Timothy R., additional

Published
2020
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134. Field Application of Digital Technologies for Health Assessment in the 10,000 Families Study

Author

Thyagarajan, Bharat, primary, Nelson, Heather H., additional, Poynter, Jenny N., additional, Prizment, Anna E., additional, Roesler, Michelle A., additional, Cassidy, Erin, additional, Putnam, Sara, additional, Amos, Laura, additional, Hickle, Andrea, additional, Reilly, Cavan, additional, Spector, Logan G., additional, and Lazovich, DeAnn, additional

Published
2020
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136. Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines and colorectal cancer incidence among African Americans and whites: The Atherosclerosis Risk in Communities study

Author

Onyeaghala, Guillaume, primary, Lintelmann, Anna K., additional, Joshu, Corrine E., additional, Lutsey, Pamela L., additional, Folsom, Aaron R., additional, Robien, Kimberly, additional, Platz, Elizabeth A., additional, and Prizment, Anna E., additional

Published
2019
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137. Sucrose Intakes and Incident Colorectal Cancer Risk among Women.

Author

Kiran, Nfn, Prizment, Anna E., Lazovich, DeAnn, Mao, Ziling, and Bostick, Roberd M.

Abstract

Background: High sucrose intakes are hypothesized to increase colorectal cancer (CRC) risk by several mechanisms, and sucrose intakes have been consistently positively associated with CRC risk in case-control studies. However, all but one prospective study reported a null sucrose-CRC association. The only prospective study to report a positive association was the Iowa Women’s Health Study (IWHS) of 35,221 cancer-free Iowa women, aged 55(69 years old at baseline in 1986, after four years of follow up. Materials and methods: To address the discrepant findings in the literature, after 26 years of follow up in the IWHS, we updated and expanded on our earlier reported analyses. During follow up through 2012, 1,731 women were diagnosed with CRC. Baseline dietary intakes were assessed with a Willett semiquantitative food frequency questionnaire. We used multivariable Cox proportional hazards regression models to estimate adjusted hazards ratios (HRs) and their 95% confidence intervals (CI). Results: For those in the highest relative to the lowest intake quintiles, the adjusted HRs (95% CI) for CRC were 1.04 (0.87-1.23; Ptrend ¼ 0.59) for sucrose, 1.00 (0.82-1.21; Ptrend ¼ 0.67) for sucrosecontaining foods, and 1.01, (0.83-1.22; Ptrend ¼ 0.56) for nondairy sucrose-containing foods, respectively. These findings did not differ substantially by colorectal site or according to categories of selected participant characteristics. Conclusions: Our findings do not support that intakes of sucrose or sucrose-containing foods are substantially associated with CRC risk among older women. [ABSTRACT FROM AUTHOR]

Published
2022
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138. Dietary and Lifestyle Oxidative Balance Scores and Incident Colorectal Cancer Risk among Older Women; the Iowa Women's Health Study.

Author

Mao, Ziling, Prizment, Anna E., Lazovich, DeAnn, Gibbs, David C., and Bostick, Roberd M.

Subjects
*LIFESTYLES, *CONFIDENCE intervals, *MULTIVARIATE analysis, *DIET, *REGRESSION analysis, *COLORECTAL cancer, *OXIDATIVE stress, *RISK assessment, *QUESTIONNAIRES, *PROPORTIONAL hazards models, *DISEASE risk factors, *OLD age
Abstract

Basic science literature strongly supports a role of oxidative stress in colorectal cancer (CRC) etiology, but in epidemiologic studies, associations of most individual exposures with CRC have been weak or inconsistent. However, recent epidemiologic evidence suggests that the collective effects of these exposures on oxidative balance and CRC risk may be substantial. Using food frequency and lifestyle questionnaire data from the prospective Iowa Women's Health Study (1986-2012), we investigated associations of 11-component dietary and 4-component lifestyle oxidative balance scores (OBS) with incident CRC using multivariable Cox proportional hazards regression. Of the 33,736 cancer-free women aged 55-69 years at baseline, 1,632 developed CRC during follow-up. Among participants in the highest relative to the lowest dietary and lifestyle OBS quintiles (higher anti-oxidant relative to pro-oxidant exposures), the adjusted hazard ratios (HRs) and their 95% confidence intervals (CI) were, respectively, 0.77 (0.63, 0.94) (Ptrend=0.02) and 0.61 (0.52, 0.71) (Ptrend<0.0001). Among those in the highest relative to the lowest joint lifestyle/dietary OBS quintile, the HR was 0.45 (95% CI 0.26, 0.77). Our findings suggest that a predominance of antioxidant over pro-oxidant dietary and lifestyle exposures—separately and especially jointly—may be inversely associated with CRC risk among older women. [ABSTRACT FROM AUTHOR]

Published
2021
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139. Efficacy and Adverse Events of Docetaxel for Metastatic, Hormone-sensitive Prostate Cancer Among Elderly Men: A Post Hoc Analysis of the CHAARTED Trial.

Author

Li, Eric V., Siddiqui, Mohammad R., Weiner, Adam B., Prizment, Anna E., Ryan, Charles J., and Morgans, Alicia K.

Subjects
DOCETAXEL, PROSTATE cancer, ANDROGEN deprivation therapy, PROGRESSION-free survival, KAPLAN-Meier estimator
Abstract

This post hoc analysis of the CHAARTED trial compared efficacy/adverse events in different age groups for docetaxel/androgen deprivation therapy vs. androgen deprivation therapy alone. We found no significant difference in efficacy among age groups, but men > 70 years were more likely to have adverse events. Treatment benefit must be weighed with toxicity in geriatric patients, particularly in real-world settings. Background: Combination therapy with docetaxel and androgen deprivation therapy (ADT) prolongs overall survival (OS) in men with metastatic hormone-sensitive prostate cancer. We assessed the benefits and adverse effects of docetaxel and ADT in relation to advancing age. Methods: We performed a post hoc analysis of the CHAARTED trial comparing docetaxel and ADT vs. ADT alone (n = 773). Patients were stratified in age groups <60, 60-70, and >70 years old. Multivariable-adjusted progression-free survival (PFS) and OS were assessed using Kaplan-Meier curves and compared using multivariable Cox regressions with calculated interaction terms between age group and treatment arm. In the combination arm, the incidence of ≥1 adverse event (grade ≥3) and the number of adverse events per patient were compared for each age group using multivariable logistic and linear regressions, respectively. Results: After adjusting for clinical variables, docetaxel's effect did not vary by age group for PFS and OS. There was no significant difference in the odds ratio of ≥1 adverse event (P > .1 for age groups 60-70 and >70 years old compared with <60 years old). However, men age >70 years old experienced +0.37 more adverse events per patient compared with men age <60 years old (95% CI, 0.11-0.64; P = .006). Conclusions: PFS and OS were similar across age groups for the combination of docetaxel and ADT compared with ADT. Older men experienced a modest increase in adverse events per patient, highlighting the importance of balancing treatment benefits and adverse effects in this age group. [ABSTRACT FROM AUTHOR]

Published
2021
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140. Abstract PR09: Field application of digital technologies for health assessment in the 10,000 Families Study

Author

Bharat Thyagarajan, Lazovich DeAnn, Nelson H. Heather, Poynter Jen, Prizment Anna, Roesler Michelle, Cassidy Erin, Putnam Sara, Reilly Cavan, and Spector Logan

Subjects
Oncology, Epidemiology
Abstract

The 10,000 Families Study (10KFS) is a Minnesota-based cohort study designed to study longitudinal changes in health. Here we report our efforts from a pilot study of 10KFS. During health fairs hosted by the study, we measured anthropometrics, blood pressure, and grip strength; collected biospecimens; performed vision and hearing assessments; and measured lung function and cognitive function. We describe the field deployment of digital applications for measurement of cognitive function, lung function, and hearing assessment in 10KFS. We measure cognitive function using the Digital Clock Drawing (dDCT) test (Cognition Technologies Inc.), a multidimensional task that evaluates spatial skills, semantic knowledge, planning, and motor functioning. We perform spirometry to assess lung function using an Air Smart Spirometer (Pond Healthcare Innovation) that uses a spirometry app (NuvoAir) to estimate forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and peak expiratory flow (PEF). We measure hearing using an iPad-enabled audiometry device (Shoebox, Inc.) that allows us to estimate air conduction and bone conduction over a range of tones from 500-8000 Hertz. These digital devices are low cost and the measurements are readily implemented with minimal training of study staff (training time 2-3 hours). To date, we have performed these measurements on 139 10KFS participants (age range: 5 years–100 years) during an in-person clinic visit. A vast majority (88%; n=123) of eligible 10KFS participants successfully completed all these measurements; participants across the age spectrum were comfortable using these digital technologies during their clinic visit. The Digital Clock Drawing test was administered only to adults >40 years old and completion rates were 92% (n=34) for participants between 41-64 years old and 95% (n=35) for those over 65 years old. The Air Smart Spirometer was administered to participants over 4 years old without a contraindication and completion rates were 96% (n=22) for children 5-17 years old, 98% (n=64) for adults 18-64 years old, and 100% (n=36) for adults over the age of 65 years. The audiometry test was administered to participants >3 years old and completion rates were 87% (n=20) for children 4-17 years old, 100% (n=67) for adults 18-64 years old, and 100% (n=37) for adults over the age of 65 years. As compared to traditional methods for collecting information on cognitive function, lung function, and hearing, these devices allow for real-time monitoring of quality-control measures and allow deployment of standardized methods of data collection in a variety of settings that do not require specialized equipment or have space constraints. In the future we anticipate deploying these methods to a broader range of data collection venues that may include in-home visits, remote assessments, and clinic visits. This abstract is also being presented as Poster A28. Citation Format: Bharat Thyagarajan, Lazovich DeAnn, Nelson H. Heather, Poynter Jen, Prizment Anna, Roesler Michelle, Cassidy Erin, Putnam Sara, Reilly Cavan, Spector Logan. Field application of digital technologies for health assessment in the 10,000 Families Study [abstract]. In: Proceedings of the AACR Special Conference on Modernizing Population Sciences in the Digital Age; 2019 Feb 19-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(9 Suppl):Abstract nr PR09.

Published
2020

141. Analgesic Use and Ovarian Cancer Risk

Author

Trabert, Britton, Poole, Elizabeth M, White, Emily, Visvanathan, Kala, Adami, Hans-Olov, Anderson, Garnet L, Brasky, Theodore M, Brinton, Louise A, Fortner, Renee T, Gaudet, Mia, Hartge, Patricia, Hoffman-Bolton, Judith, Jones, Michael, Lacey, James V, Larsson, Susanna C, Mackenzie, Gerardo G, Schouten, Leo J, Sandler, Dale P, O'Brien, Katie, Patel, Alpa V, Peters, Ulrike, Prizment, Anna, Robien, Kim, Setiawan, Wendy V, Swerdlow, Anthony, van den Brandt, Piet A, Weiderpass, Elisabete, Wilkens, Lynne R, Wolk, Alicja, Wentzensen, Nicolas, and Tworoger, Shelley S

Subjects
Paediatrics and Reproductive Medicine, Obstetrics & Reproductive Medicine, Cancer
Published
2018

146. Abstract 5060: Effect of aspirin on gut microbiome in a pilot randomized double-blind trial

Author

Prizment, Anna E., primary, Menk, Jeremiah, additional, Staley, Christopher, additional, Vivek, Sithara, additional, Onyeaghala, Guillaume, additional, Thyagarajan, Bharat, additional, Demmer, Ryan, additional, Knights, Dan, additional, Meyer, Kathie, additional, Shaukat, Aasma, additional, Khorutz, Alexander, additional, Sadowsky, Michael J., additional, Straka, Robert J., additional, and Church, Timothy, additional

Published
2019
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