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439 results on '"Preux, P-M."'

101. Le cancer du sein en Afrique subsaharienne, un nouveau défi sanitaire

Author

Parenté, A., Gnangnon, F., Ivanga, M., Sacca, H., Laleye, A., Darré, T., Ngoungou, E., Houinato, D., Preux, P-M., and Blanquet, V.

Abstract

Les preuves d'une épidémie émergente de cancer du sein en Afrique subsaharienne (ASS) constituent une réalité épidémiologique dont l'ampleur n'a pas encore été évaluée à la mesure de sa gravité. Notre vision à long terme est de contribuer à l'amélioration de la santé de ces populations par une meilleure compréhension de l’épidémiologie et de la génétique du cancer du sein dans cette partie du monde.

Published
2023
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102. Trauma and amyotrophic lateral sclerosis: a case-control study from a population-based registry

Author

Pupillo, E, Messina, P, Logroscino, G, Zoccolella, S, Chiò, A, Calvo, A, Corbo, M, Lunetta, C, Micheli, A, Millul, A, Vitelli, E, Beghi, E, Bissolati, M, Formaglio, F, Gerardi, F, Giussani, G, Maestri, E, Prelle, A, Protti, A, Riva, N, Santoro, D, Al Chalabi, A, Berro, A, De Mercanti, S, Giacone, S, Ilardi, A, Hardiman, O, Capozzo, R, Ludolph, A, Mitchell, D, Preux, P, Swingler, R, van den Berg, L, Alvisi, E, Cereda, C, Ceroni, M, Citterio, A, di Poggio, M, Caponnetto, C, Buzzi, P, Colombo, I, Cotelli, M, Filosto, M, Padovani, A, De Lodovici, L, Ferrarese, C, Tremolizzo, L, Fetoni, V, Palazzini, E, Guaita, M, Perrone, P, Secchi, P, Lorusso, L, Sidoti, V, Perini, M, Tavernelli, F, Rigamonti, A, Berro, AC, Mitchell, Dl, Preux, P. M, di Poggio, MB, Cotelli, MS, Guaita, MC, Rigamonti, A., FERRARESE, CARLO, TREMOLIZZO, LUCIO, Pupillo, E, Messina, P, Logroscino, G, Zoccolella, S, Chiò, A, Calvo, A, Corbo, M, Lunetta, C, Micheli, A, Millul, A, Vitelli, E, Beghi, E, Bissolati, M, Formaglio, F, Gerardi, F, Giussani, G, Maestri, E, Prelle, A, Protti, A, Riva, N, Santoro, D, Al Chalabi, A, Berro, A, De Mercanti, S, Giacone, S, Ilardi, A, Hardiman, O, Capozzo, R, Ludolph, A, Mitchell, D, Preux, P, Swingler, R, van den Berg, L, Alvisi, E, Cereda, C, Ceroni, M, Citterio, A, di Poggio, M, Caponnetto, C, Buzzi, P, Colombo, I, Cotelli, M, Filosto, M, Padovani, A, De Lodovici, L, Ferrarese, C, Tremolizzo, L, Fetoni, V, Palazzini, E, Guaita, M, Perrone, P, Secchi, P, Lorusso, L, Sidoti, V, Perini, M, Tavernelli, F, Rigamonti, A, Berro, AC, Mitchell, Dl, Preux, P. M, di Poggio, MB, Cotelli, MS, Guaita, MC, Rigamonti, A., FERRARESE, CARLO, and TREMOLIZZO, LUCIO

Abstract

BACKGROUND AND PURPOSE: Published reports on the association between amyotrophic lateral sclerosis (ALS) and trauma are controversial suggesting the need for a new case-control study done in a large population. METHODS: A case-control study was undertaken in Italy to assess this association. Cases were patients with newly diagnosed ALS from four population-based registries. For each case, two hospital controls were selected, matched for age, sex, and province of residence, one with a neurological (non-degenerative) disease and one with a non-neurological disease (other than orthopedic or surgical). Traumatic events (defined as accidental events causing injuries requiring medical care) were recorded with details on type, site, timing, severity, and complications. The risks were assessed as odds ratios (ORs) with 95% confidence intervals (CI), crude and adjusted for age, sex, education, interviewee (patient or surrogate), physical activity, smoking, alcohol, and coffee. RESULTS: The study population comprised 377 patients in each of the three groups. One or more traumatic events were reported by 225 cases (59.7%), 191 neurological controls (50.7%), and 179 non-neurological controls (47.5%) (P < 0.01) (OR 1.63; 95% CI 1.25-2.14) (P < 0.01). The ORs were 3.07 (95% CI 1.86-5.05) for patients reporting 3+ traumatic events and 2.44 (95% CI 1.36-4.40) for severe traumatic events. The ORs remained significant when the analysis was limited to events occurred 5+ and 10+ years before ALS onset, to incident ALS, and direct informant. CONCLUSION: Antecedent trauma, repeated trauma, and severe trauma may be risk factors for ALS.

Published
2012

144. Epilepsy and neurocysticercosis in an Andean community

Author

Cruz, M. E., primary, Schantz, P. M., additional, Cruz, I., additional, Espinosa, P., additional, Preux, P. M., additional, Cruz, A., additional, Benitez, W., additional, Tsang, V. C., additional, Fermoso, J., additional, and Dumas, M., additional

Published
1999
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149. Multiple sclerosis and solar exposure before the age of 15 years: case--control study in Cuba, Martinique and Sicily.

Author

Dalmay, F., Bhalla, D., Nicolett, A., Cabrera-Gomez, J. A., Cabre, P., Ruiz5, F., Druet-Cabanac, M., Dumas, M., and Preux, P. M.

Subjects
MULTIPLE sclerosis, EPIDEMIOLOGY, MULTIVARIATE analysis, SUNSHINE, CASE-control method
Abstract

Few studies report a protective role of childhood solar exposure to multiple sclerosis. Our objective was to confirm the protective role of childhood solar exposure in multiple sclerosis in Cuba, Martinique and Sicily. This was a matched case-control study, and cases met Poser criteria for clinically, laboratory (definite, probable) multiple sclerosis. Controls were resident population, without neurological disorder, living close to cases (within 100 km), matched for sex, age (±5 years), residence before age 15. We recruited 551 subjects during a 1-year period (193 cases, Cuba n = 95, Sicily n = 50, Martinique n = 48; 358 controls). Some (89%) met definite clinical multiple sclerosis criteria (relapsing remitting form (with and without sequel) (74%), secondary progressive (21%), primary progressive (5%)). Odds ratios in a univariate analysis were: family history of multiple sclerosis (5.1) and autoimmune disorder (4.0); wearing shirt (3.5), hat (2.7), pants (2.4); sun exposure causing sunburn (1.8); sun exposure duration (1 h more/day; weekends 0.91, weekdays 0.86); bare-chested (0.6); water sports (0.2). Independent factors in the multivariate analysis were family history of multiple sclerosis (4.8 (1.50-15.10)), wearing pants under sunlight (1.9 (1.10-3.20)), sun exposure duration (1 h more/day, weekdays 0.90 (0.85-0.98), weekends 0.93 (0.87-0.99)), water sports (0.23 (0.13-0.40)). We conclude that outdoor leisure activities in addition to sun exposure reports are associated with a reduced multiple sclerosis risk, with evidence of dose response. [ABSTRACT FROM AUTHOR]

Published
2010
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150. Differential transesophageal echocardiographic diagnosis between linear artifacts and intraluminal flap of aortic dissection or disruption.

Author

Vignon P, Spencer KT, Rambaud G, Preux P, Krauss D, Balasia B, Lang RM, Vignon, P, Spencer, K T, Rambaud, G, Preux, P M, Krauss, D, Balasia, B, and Lang, R M

Abstract

Background: The relatively low specificity of transesophageal echocardiography (TEE) for the diagnosis of aortic dissection (AD) or traumatic disruption of the aorta (TDA) has been attributed to linear artifacts. We sought to determine the incidence of intra-aortic linear artifacts in a cohort of patients with suspected AD or TDA, to establish the differential TEE diagnostic criteria between these artifacts and true aortic flaps, and to evaluate their impact on TEE diagnostic accuracy.Methods and Results: During an 8-year period, patients at high risk of AD (n = 261) or TDA (n = 90) who underwent a TEE study and had confirmed final diagnoses were studied. In an initial retrospective series, linear artifacts were observed within the ascending and descending aorta in 59 of 230 patients (26%) and 17 of 230 patients (7%), respectively. TEE findings associated with linear artifacts in the ascending aorta were as follows: displacement parallel to aortic walls; similar blood flow velocities on both sides; angle with the aortic wall > 85 degrees; and thickness > 2.5 mm. Diagnostic criteria of reverberant images in the descending aorta were as follows: displacement parallel to aortic walls, overimposition of blood flow, and similar blood flow velocities on both sides of the image. In a subsequent prospective series (n = 121), systematic use of these diagnostic criteria resulted in improved TEE specificity for the identification of true intra-aortic flaps.Conclusions: Misleading intra-aortic linear artifacts are frequently observed in patients undergoing a TEE study for suspected AD or TDA. Routine use of the herein-proposed diagnostic criteria promises to further improve TEE diagnostic accuracy in the setting of severely ill patients with potential need for prompt surgery. [ABSTRACT FROM AUTHOR]

Published
2001
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