Search

According to recent research from Trondheim, Norway, 'BE-14106 is a macrocyclic lactam with an acyl side chain previously identified in a marine-derived Streptomyces sp. The gene cluster for BE-14106 biosynthesis [...]

'iso-Migrastatin and related glutarimide-containing polyketides are potent inhibitors of tumor cell migration and their implied potential as antimetastatic agents for human cancers has garnered significant attention. Genome scanning of Streptomyces [...]

'Malonylation of an acyl carrier protein (ACP) by malonyl Coenzyme A-ACP transacylase (MCAT) is fundamental to bacteria( fatty acid biosynthesis. Here, we report the structure of the Steptomyces coelicolor (Sc) [...]

'The last steps of the biosynthesis of mycolic acids, essential and specific lipids of Mycobacterium tuberculosis and related bacteria, are catalyzed by proteins encoded by the fadD32-pks13-accD4 cluster. Here, we [...]

According to recent research published in the Journal of Bacteriology, 'Type III polyketide synthases (PKSs) synthesize a variety of aromatic polyketides in plants, fungi, and bacteria. The bacterial genome projects [...]

According to recent research published in the Journal of Biological Chemistry, 'The biosynthesis of the enediyne moiety of the antitumor natural product calicheamicin involves an iterative polyketide synthase (CalE8) and [...]

New investigation results, 'Transfer, stable maintenance and expression of the mycolactone polyketide megasynthase mls genes in a recombination-impaired Mycobacterium marinum,' are detailed in a study published in Microbiology. "The human [...]

'Natural product chemical diversity is fuelled by the emergence and ongoing evolution of biosynthetic pathways in secondary metabolism(1). However, co-evolution of enzymes for metabolic diversification is not well understood, especially [...]

Fresh data on enzyme research are presented in the report 'fabC of Streptomyces lydicus involvement in the biosynthesis of streptolydigin.' According to a study from People's Republic of China, 'Streptolydigin, [...]

According to a study from the United States, "Fumonisins are polyketide-derived mycotoxins produced by several plant pathogenic fungi. The toxins cause several fatal diseases in domestic animals and are associated [...]

'2,6-Disubstituted dihydropyrans are a common feature in many bioactive polyketides, including the anticancer marine polyketide laulimalide. While much of the uncharacterized biosynthetic pathway for laulimalide can be confidently postulated, the [...]

'Type II thioesterases (TE IIs) were shown to maintain the efficiency of polyketide synthases (PKSs) by removing acyl residues blocking extension modules. However, the substrate specificity and kinetic parameters of [...]

According to recent research published in the journal Chembiochem, 'Lasalocid is a highly atypical polyether ionophoric antibiotic, firstly because it contains a type of aromatic ring normally associated with fungal [...]

'Although bacterial iterative Type I polyketide synthases are now known to participate in the biosynthesis of a small set of diverse natural products, the subsequent downstream modification of the resulting [...]

'Multiple versions of the DEBS 1-TE gene, which encodes a truncated bimodular polyketide synthase (PKS) derived from the erythromycin-producing PKS, were created by replacing the DNA encoding the ketoreductase (KR) [...]

According to recent research from Bristol, the United Kingdom, 'The actinorhodin (act) synthase acyl carrier protein (ACP) from Streptomyces coelicolor plays a central role in polyketide biosynthesis. Polyketide intermediates are [...]

'The final step in polyketide synthase-mediated biosynthesis of macrocyclic polyketides is thioesterase (TE)-catalyzed cyclization of a linear polyketide acyl chain. TEs are highly specific in the chemistry they catalyze,' investigators [...]

'The polyketide signaling metabolites bacillaene and dihydrobacillaene are biosynthesized in Bacillus subtilis on an enzymatic assembly line with both nonribosomal peptide synthetase (NRPS) and polyketide synthase (IRKS) modules acting along [...]

A new study, 'Localization of the ActIII actinorhodin polyketide ketoreductase to the cell wall,' is now available. 'Structurally diverse polyketides provide a rich reservoir of bioactive molecules. Actinorhodin, a model [...]

'Tylactone synthase (TYLS) is a modular polyketide synthase that catalyzes the formation of tylactone (1), the parent aglycone precursor of the macrolide antibiotic tylosin. TYLS modules 1 and 2 are [...]

'Resorcylic acid lactones represent a unique class of fungal polyketides and display a wide range of biological activities, such as nanomolar inhibitors of Hsp90 and MAP kinase. The biosynthesis of [...]

Scientists discuss in 'Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation' new findings in life sciences (see also Life Sciences). "Phenolic glycolipids (PGLs) are [...]

New investigation results, 'Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene,' are detailed in a study published in Applied Microbiology and Biotechnology (see also [...]

"An unexpected biochemical strategy for chain initiation is described for the loading module of the polyketide synthase of curacin A, an anticancer lead derived from the marine cyanobacterium Lyngbya majuscula [...]

Current study results from the report, 'Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway,' have been published (see also Biological Chemistry). According to a study from the United [...]

Current study results from the report, "Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140. Discrete, monofunctional adenylation enzyme and peptidyl carrier protein that directly load [...]

Scientists from Mississippi State University, U.S., publish new research findings. This trend article about Mississippi State University, U.S., is an immediate alert from NewsRx to identify developing directions of research. [...]

New investigation results, "Biochemical characterization of the minimal polyketide synthase domains in the lovastatin nonaketide synthase LovB," are detailed in a study published in FEBS Journal. According to recent research [...]

Investigators publish new data in the report "Biogeography of actinomycete communities and type II polyketide synthase genes in soils collected in New Jersey and Central Asia." According to recent research [...]

Research findings, "Substrate tolerance of module 6 of the epothilone synthetase," are discussed in a new report. According to recent research from the United States, "The epothilone synthetase is a [...]

New studies from University of Cape Town, South Africa, outlined. This trend article about University of Cape Town, South Africa, is an immediate alert from NewsRx to identify developing directions [...]

Investigators publish new data in the report "Characterization of a large, stable, high-copy-number Streptomyces plasmid that requires stability and transfer functions for heterologous polyketide overproduction." According to recent research from [...]

A report, "Catalytic relationships between type I and type II iterative polyketide synthases: The Aspergillus parasiticus norsolorinic acid synthase," is newly published data in ChemBioChem. "Norsolorinic acid synthase (NSAS) is [...]

New research, "Novel benzene ring biosynthesis from C(3) and C(4) primary metabolites by two enzymes," is the subject of a report. "The shikimate pathway, including seven enzymatic steps for production [...]

Seoul National University, South Korea, describe new medical findings. This trend article about Seoul National University, South Korea, is an immediate alert from NewsRx to identify developing directions of research. [...]

Privately-held UK-based biotechnology firm Biotica Technology and the University of Cambridge have secured funding for a collaborative research initiative into into new heterologous expression systems for the production of polyketides, [...]

* Biotics Technology, of Cambridge, UK, filed a patent on a novel version of the polyketide borrelidin, which it has engineered to be an anti-angiogenic and cytotoxic agent. The company [...]