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103. The role of flavin mononucleotide (FMN) as a potentially clinically relevant biomarker to predict the quality of kidney grafts during hypothermic (oxygenated) machine perfusion.

Author

van de Leemkolk, Fenna E. M., Lo Faro, M. Letizia, Shaheed, Sadr, Mulvey, John F., Huurman, Volkert A. L., Alwayn, Ian P. J., Putter, Hein, Jochmans, Ina, Lindeman, Jan H. N., and Ploeg, Rutger J.

Subjects
FLAVIN mononucleotide, PERFUSION, KIDNEYS, LIQUID chromatography-mass spectrometry, BIOMARKERS, FLUORESCENCE spectroscopy
Abstract

Hypothermic machine perfusion (HMP) provides preservation superior to cold storage and may allow for organ assessment prior to transplantation. Since flavin mononucleotide (FMN) in perfusate has been proposed as a biomarker of organ quality during HMP of donor livers, the aim of this study was to validate FMN as a biomarker for organ quality in the context of HMP preserved kidneys. Perfusate samples (n = 422) from the paired randomised controlled COPE-COMPARE-trial, comparing HMP with oxygenation (HMPO2) versus standard HMP in kidneys, were used. Fluorescence intensity (FI) was assessed using fluorescence spectroscopy (excitation 450nm; emission 500-600nm) and validated by fluorospectrophotometer and targeted liquid chromatography mass spectrometry (LC-MS/MS). Fluorescence intensity (FI)(ex450;em500-600) increased over time during machine perfusion in both groups (p<0.0001). This increase was similar for both groups (p = 0.83). No correlation, however, was found between FI(ex450;em500-600) and post-transplant outcomes, including day 5 or 7 serum creatinine (p = 0.11; p = 0.16), immediate graft function (p = 0.91), creatinine clearance and biopsy-proven rejection at one year (p = 0.14; p = 0.59). LC-MS/MS validation experiments of samples detected FMN in only one perfusate sample, whilst the majority of samples with the highest fluorescence (n = 37/38, 97.4%) remained negative. In the context of clinical kidney HMP, fluorescence spectroscopy unfortunately appears to be not specific and probably unsuitable for FMN. This study shows that FMN does not classify as a clinically relevant predictive biomarker of kidney graft function after transplantation. [ABSTRACT FROM AUTHOR]

Published
2023
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104. List of Contributors

Author

Abecassis, Michael, primary, Abed, Ahmed, additional, Abelli, Massimo, additional, Ahmad, Sarwat, additional, Alessiani, Mario, additional, Alsharidi, Aynaa, additional, Altruda, Fiorella, additional, Amorese, Gabriella, additional, Angeletti, Andrea, additional, Angelico, Mario, additional, Angelico, Roberta, additional, Angelotti, Maria L., additional, Applegate, Robert J., additional, Atala, Anthony, additional, Attanasio, Chiara, additional, Axelrod, David, additional, Bababekov, Yanik, additional, Basu, Joydeep, additional, Becherucci, Francesca, additional, Belford, P. Matthew, additional, Benedetti, Enrico, additional, Benedetti, Valentina, additional, Benigni, Ariela, additional, Bertram, Timothy A., additional, Bestard, Oriol, additional, Blake, Joshua, additional, Boggi, Ugo, additional, Brasile, Lauren, additional, Bromberg, Jonathan S., additional, Brouard, Sophie, additional, Brovold, Matthew, additional, Burke, George W., additional, Busic, Mirela, additional, Butt, Zeeshan, additional, Caddeo, Silvia, additional, Calzone, Stefano, additional, Campistol, Josep M., additional, Carmagnola, Irene, additional, Carty, Fiona, additional, Castanares-Zapatero, Diego, additional, Chadjichristos, Christos E., additional, Chambers, Brooke E., additional, Chandran, Sindhu, additional, Chatziantoniou, Christos, additional, Chen, Ashton, additional, Chen, Linda, additional, Chen, Xiwu, additional, Chiono, Valeria, additional, Chiusa, Manuel, additional, Ciancio, Gaetano, additional, Ciardelli, Gianluca, additional, Coletti, Gino, additional, Coll, Elisabeth, additional, Collienne, Christine, additional, Colvin, Robert B., additional, Cortinovis, Monica, additional, Cosimi, A. Benedict, additional, Cravedi, Paolo, additional, D’Amico, Giuseppe, additional, Da Sacco, Stefano, additional, Danger, Richard, additional, Dantal, Jacques, additional, Davidson, Alan J., additional, De Chiara, Letizia, additional, De Fijter, Johannes W., additional, de la Rosa, Gloria, additional, Delmonico, Francis L., additional, Deng, Junhong, additional, Deurdulian, Corinne, additional, Dhal, Abritee, additional, Dionigi, Paolo, additional, Domínguez-Gil, Beatriz, additional, Drozdzik, Marek, additional, Dussaule, Jean-Claude, additional, Edgar, Lauren, additional, Egidi, Maria Francesca, additional, El Hennawy, Hany, additional, English, Karen, additional, Everly, Matthew J., additional, Fagoonee, Sharmila, additional, Famulari, Elvira Smeralda, additional, Farney, Alan C., additional, Figliuzzi, Marina, additional, Framarino-dei-Malatesta, Marialuisa, additional, Fumo, David E., additional, Gagliardini, Elena, additional, Gallon, Lorenzo, additional, Gandhi, Sanjay K., additional, Gautreaux, Michael D., additional, Geraedts, Anna, additional, Giannese, Domenico, additional, Giulianotti, Pier C., additional, Goligorsky, Michael S., additional, Griesemar, Adam, additional, Grinyó, Josep M., additional, Gruessner, Angelika C., additional, Gruessner, Rainer W.G., additional, He, Bulang, additional, Heher, Eliot, additional, Ho, Bing, additional, Hosgood, Sarah A., additional, Hotta, Kiyohiko, additional, Humar, Atul, additional, Humes, H. David, additional, Iaria, Giuseppe, additional, Imberti, Barbara, additional, Izpisua Belmonte, Juan Carlos, additional, Jochmans, Ina, additional, Katari, Ravi, additional, Kavvadas, Panagiotis, additional, Kawai, Tatsuo, additional, Kengla, Carlos, additional, Keys, Tristan, additional, Kidiyoor, Amritha, additional, Kidokoro, Kengo, additional, Kumar, Deepali, additional, Kutcher, Michael A., additional, Lai, Quirino, additional, Laterre, Pierre-François, additional, Lebbé, Céleste, additional, Legendre, Christophe, additional, Lennon, Rachel, additional, Li, Peng, additional, Lin, Jen-Jar, additional, Little, Melissa H., additional, Lu, Xiongbing, additional, Ludlow, John W., additional, Mahíllo, Beatriz, additional, Masereeuw, Rosalinde, additional, Matesanz, Rafael, additional, Matovinovic, Mirjana S., additional, Mazzinghi, Benedetta, additional, Mbiandjeu Toya, Serge Cedrick, additional, McEwen, Scott, additional, Melandro, Fabio, additional, Melchiorri, Loredana, additional, Menon, Madhav C., additional, Mirzazadeh, Majid, additional, Montag, Samantha, additional, Montgomery, Robert A., additional, Montiel, Virginie, additional, Montserrat, Nuria, additional, Morigi, Marina, additional, Morrill, Christian C., additional, Mourad, Michel, additional, Murphy, Sean V., additional, Murray, Patricia, additional, Nardo, Tiziana, additional, Netti, Paolo A., additional, Nguyen, Mark, additional, Nicholson, Michael L., additional, O’Callaghan, John M., additional, Ohler, Linda, additional, Orlando, Giuseppe, additional, Osafune, Kenji, additional, Oura, Tetsu, additional, Peired, Anna, additional, Peloso, Andrea, additional, Peng, Zhenzhen, additional, Perico, Norberto, additional, Perin, Laura, additional, Perrone, Vittorio, additional, Persad, Paul, additional, Peti-Peterdi, János, additional, Petrosyan, Astgik, additional, Pietrabissa, Andrea, additional, Pino, Christopher J., additional, Pirenne, Jacques, additional, Pisani, Francesco, additional, Ploeg, Rutger J., additional, Porrini, Esteban, additional, Pozzi, Ambra, additional, Pugliese, Alberto, additional, Pugliese, Luigi, additional, Rabelink, Ton J., additional, Rampino, Teresa, additional, Rees, Michael A., additional, Reinders, Marlies E.J., additional, Remuzzi, Andrea, additional, Remuzzi, Giuseppe, additional, Riquier-Brison, Anne, additional, Roca, Raquel G., additional, Rogers, Jeffrey, additional, Romagnani, Paola, additional, Rosales, Ivy A., additional, Rosenblum, Norman D., additional, Rota, Cinzia, additional, Ruggenenti, Piero, additional, Ruini, Francesca, additional, Sageshima, Junichiro, additional, El Salem, Fadi, additional, Sandal, Shaifali, additional, Sander, Veronika, additional, Santeramo, Ilaria, additional, Santos, Renato M., additional, Sarwal, Minnie, additional, Shah, Jigesh, additional, Shetty, Aneesha A., additional, Silengo, Lorenzo, additional, Siskind, Eric, additional, Skaro, Anton, additional, Snanoudj, Renaud, additional, Soker, Shay, additional, South, Andrew M., additional, Spasovski, Goce, additional, Stratta, Robert J., additional, Strom, Charles, additional, Stubenitsky, Bart, additional, Tamburrini, Riccardo, additional, Tang, Qizhi, additional, Tantissattamo, Ekamol, additional, Tasaki, Masayuki, additional, Tchelepi, Hisham, additional, Ticozzelli, Elena, additional, Traitanon, Opas, additional, Trillini, Matias, additional, Tzvetanov, Ivo, additional, Valentín, María O., additional, Vincenti, Flavio, additional, Vistoli, Fabio, additional, Vriend, Jelle, additional, Walker, Stephen J., additional, Wertheim, Jason A., additional, Williams, David F., additional, Wilm, Bettina, additional, Wilmer, Martijn J., additional, Wingert, Rebecca A., additional, Wittebole, Xavier, additional, Xia, Yun, additional, Xinaris, Christodoulos, additional, Yamada, Kazuhiko, additional, Yokoo, Takashi, additional, Yokote, Shinya, additional, Zandvliet, Maarten L., additional, Zent, Roy, additional, Zhang, Yuanyuan, additional, Zhao, David X., additional, Zhao, Lihui, additional, and Zhao, Susan Y., additional

Published
2017
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105. Kidney Preservation

Author

Jochmans, Ina, primary, O’Callaghan, John M., additional, Ploeg, Rutger J., additional, and Pirenne, Jacques, additional

Published
2017
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110. Incidence, Risk Factors, and Effect on Allograft Survival of Glomerulonephritis Post-transplantation in a United Kingdom Population: Cohort Study

Author

Aguiar, Rute, primary, Bourmpaki, Elli, additional, Bunce, Catey, additional, Coker, Bola, additional, Delaney, Florence, additional, de Jongh, Leonardo, additional, Oliveira, Giovani, additional, Weir, Alistair, additional, Higgins, Finola, additional, Spiridou, Anastasia, additional, Hasan, Syed, additional, Smith, Jonathan, additional, Mulla, Abdulrahim, additional, Glampson, Ben, additional, Mercuri, Luca, additional, Montero, Rosa, additional, Hernandez-Fuentes, Maria, additional, Roufosse, Candice A., additional, Simmonds, Naomi, additional, Clatworthy, Menna, additional, McLean, Adam, additional, Ploeg, Rutger, additional, Davies, Jim, additional, Várnai, Kinga Anna, additional, Woods, Kerrie, additional, Lord, Graham, additional, Pruthi, Rishi, additional, Breen, Cormac, additional, and Chowdhury, Paramit, additional

Published
2022
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111. Kidney Normothermic Machine Perfusion Can Be Used as a Preservation Technique and a Model of Reperfusion to Deliver Novel Therapies and Assess Inflammation and Immune Activation

Author

Mellati, Azita, primary, Lo Faro, Letizia, additional, Dumbill, Richard, additional, Meertens, Pommelien, additional, Rozenberg, Kaithlyn, additional, Shaheed, Sadr, additional, Snashall, Corinna, additional, McGivern, Hannah, additional, Ploeg, Rutger, additional, and Hunter, James, additional

Published
2022
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113. Donor characteristics and their impact on kidney transplantation outcomes:Results from two nationwide instrumental variable analyses based on outcomes of donor kidney pairs accepted for transplantation

Author

Schaapherder, Alexander F., Kaisar, Maria, Mumford, Lisa, Robb, Matthew, Johnson, Rachel, de Kok, Michèle J.C., Bemelman, Frederike J., van de Wetering, Jacqueline, van Zuilen, Arjan D., Christiaans, Maarten H.L., Baas, Marije C., Nurmohamed, Azam S., Berger, Stefan P., Bastiaannet, Esther, de Vries, Aiko P.J., Sharples, Edward, Ploeg, Rutger J., Lindeman, Jan H.N., Schaapherder, Alexander F., Kaisar, Maria, Mumford, Lisa, Robb, Matthew, Johnson, Rachel, de Kok, Michèle J.C., Bemelman, Frederike J., van de Wetering, Jacqueline, van Zuilen, Arjan D., Christiaans, Maarten H.L., Baas, Marije C., Nurmohamed, Azam S., Berger, Stefan P., Bastiaannet, Esther, de Vries, Aiko P.J., Sharples, Edward, Ploeg, Rutger J., and Lindeman, Jan H.N.

Abstract

Background: Donor-characteristics and donor characteristics-based decision algorithms are being progressively used in the decision process whether or not to accept an available donor kidney graft for transplantation. While this may improve outcomes, the performance characteristics of the algorithms remains moderate. To estimate the impact of donor factors of grafts accepted for transplantation on transplant outcomes, and to test whether implementation of donor-characteristics-based algorithms in clinical decision-making is justified, we applied an instrumental variable analysis to outcomes for kidney donor pairs transplanted in different individuals. Methods: This analysis used (dis)congruent outcomes of kidney donor pairs as an instrument and was based on national transplantation registry data for all donor kidney pairs transplanted in separate individuals in the Netherlands (1990-2018, 2,845 donor pairs), and the United Kingdom (UK, 2000-2018, 11,450 pairs). Incident early graft loss (EGL) was used as the primary discriminatory factor. It was reasoned that a scenario with a dominant impact of donor variables on transplantation outcomes would result in high concordance of EGL in both recipients, whilst dominance of asymmetrical outcomes could indicate a more complex scenario, involving an interaction of donor, procedural and recipient factors. Findings: Incidences of congruent EGL (Netherlands: 1·2%, UK: 0·7%) were slightly lower than the arithmetical (stochastic) incidences, suggesting that once a graft has been accepted for transplantation, donor factors minimally contribute to incident EGL. A long-term impact of donor factors was explored by comparing outcomes for functional grafts from donor pairs with asymmetrical vs. symmetrical outcomes. Recipient survival was similar for both groups, but a slightly compromised graft survival was observed for grafts with asymmetrical outcomes in the UK cohort: (10-years Hazard Ratio for graft loss: 1·18 [1·03-1·35] p<0

Published
2022

114. Donor characteristics and their impact on kidney transplantation outcomes: Results from two nationwide instrumental variable analyses based on outcomes of donor kidney pairs accepted for transplantation

Author

MS Nefrologie, Circulatory Health, Schaapherder, Alexander F, Kaisar, Maria, Mumford, Lisa, Robb, Matthew, Johnson, Rachel, de Kok, Michèle J C, Bemelman, Frederike J, van de Wetering, Jacqueline, van Zuilen, Arjan D, Christiaans, Maarten H L, Baas, Marije C, Nurmohamed, Azam S, Berger, Stefan P, Bastiaannet, Esther, de Vries, Aiko P J, Sharples, Edward, Ploeg, Rutger J, Lindeman, Jan H N, MS Nefrologie, Circulatory Health, Schaapherder, Alexander F, Kaisar, Maria, Mumford, Lisa, Robb, Matthew, Johnson, Rachel, de Kok, Michèle J C, Bemelman, Frederike J, van de Wetering, Jacqueline, van Zuilen, Arjan D, Christiaans, Maarten H L, Baas, Marije C, Nurmohamed, Azam S, Berger, Stefan P, Bastiaannet, Esther, de Vries, Aiko P J, Sharples, Edward, Ploeg, Rutger J, and Lindeman, Jan H N

Published
2022

118. Assessment of Mitochondrial Function and Oxygen Consumption Measured During Ex Vivo Normothermic Machine Perfusion of Injured Pig Kidneys Helps to Monitor Organ Viability

Author

Hunter, James P., primary, Faro, Letizia Lo, additional, Rozenberg, Kaithlyn, additional, Dengu, Fungai, additional, Ogbemudia, Anne, additional, Weissenbacher, Annemarie, additional, Mulvey, John F., additional, Knijff, Laura, additional, Gopalakrishnan, Kishore, additional, and Ploeg, Rutger J., additional

Published
2022
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123. Additional file 1 of Integrative omics reveals subtle molecular perturbations following ischemic conditioning in a porcine kidney transplant model

Author

O���Brien, Darragh P., Thorne, Adam M., Huang, Honglei, Pappalardo, Elisa, Yao, Xuan, Thyrrestrup, Peter S��ndergaard, Ravlo, Kristian, Secher, Niels, Norregaard, Rikke, Ploeg, Rutger J., Jespersen, Bente, and Kessler, Benedikt M.

Subjects
hemic and lymphatic diseases
Abstract

Additional file 1: Figure S1. Transcriptomic pathway enrichment analysis reveals subtle alteration of tissue inflammation by RIC. All transcripts (n = 33) which were found to be dysregulated in RIC versus non-RIC controls were searched against the Sus scrofa database in STRING. Only interactions of the highest confidence (scores > 0.90) were included in the analysis. Genes associated with immune regulation are highlighted, with those linked to interleukin biology coloured red, while cytokines are coloured purple. Figure S2. Proteomic pathway enrichment analysis uncovers RIC induced tissue leakage and altered inflammation. Proteins (n = 252) which were found to have the greatest dysregulation in RIC versus non-RIC controls were searched against the Sus scrofa database in STRING. Only interactions of the highest confidence (scores > 0.90) were included in the analysis. Proteins/genes of interest are highlighted, with proteins associated with muscle and ECM coloured in blue, blood coagulation in green, and factors associated with innate immunity coloured red. Figure S3. Kidney tissue phosphoproteomics unaffected by RIC. A) Abundance plots indicate no significant difference in the phosphoproteome between RIC and control groups. B) A Christmas tree plot, with Significance B thresholds colour coded. Minor changes were observed between groups.

Published
2022
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124. Development and Application of a Semi quantitative Scoring Method for Ultrastructural Assessment of Acute Stress in Pancreatic Islet

Author

Dyson, Nicola J. Kattner, Nicole Honkanen-Scott, Minna and Hunter, Bethany Doyle, Jennifer A. White, Kathryn Davey, Tracey S. Ploeg, Rutger J. Bury, Yvonne A. Tiniakos, Dina G. and Shaw, James A. M. Scott, III, William E.

Abstract

Background. Pancreas and islet transplantation outcomes are negatively impacted by injury to the endocrine cells from acute stress during donor death, organ procurement, processing, and transplant procedures. Here, we report a novel electron microscopy scoring system, the Newcastle Pancreas Endocrine Stress Score (NPESS). Methods. NPESS was adapted and expanded from our previously validated method for scoring pancreatic exocrine acinar cells, yielding a 4-point scale (0-3) classifying ultrastructural pathology in endocrine cell nuclei, mitochondria, endoplasmic reticulum, cytoplasmic vacuolization, and secretory granule depletion, with a maximum additive score of 15. We applied NPESS in a cohort of deceased organ donors after brainstem (DBD) and circulatory (DOD) death with a wide range of cold ischemic times (3.6-35.9h) including 3 donors with type 1 and 3 with type 2 diabetes to assess islets in situ (n = 30) in addition to pancreata (n = 3) pre- and postislet isolation. Results. In DBD pancreata, NPESS correlated with cold ischemic time (head: r = 0.55: P = 0.02) and mirrored exocrine score (r = 0.48; P = 0.01). When stratified by endocrine phenotype, cells with granules of heterogeneous morphology had higher scores than alpha, beta, and delta cells (P < 0.0001). Cells of mixed endocrine-exocrine morphology were observed in association with increased NPESS (P = 0.02) . Islet isolation was associated with improved NPESS (in situ: 8.39 +/- 0.77 [Mean +/- SD]; postisolation: 5.44 +/- 0.31; P = 0.04). Conclusions. NPESS provides a robust method for semiquantitative scoring of subcellular ultrastructural changes in human pancreatic endocrine cells in situ and following islet isolation with utility for unbiased evaluation of acute stress in organ transplantation research.

Published
2022

130. Abdominal multiorgan procurement from slaughterhouse pigs: a bespoke model in organ donation after circulatory death for ex vivo organ perfusion compliant with the 3 Rs (Reduction, Replacement & Refinement)

Author

Dengu, Fungai, primary, Neri, Flavia, additional, Ogbemudia, Etohan, additional, Ebeling, Georg, additional, Knijff, Laura, additional, Rozenberg, Kaithlyn, additional, Dumbill, Richard, additional, Branchereau, Julien, additional, Friend, Peter, additional, Ploeg, Rutger, additional, and Hunter, James, additional

Published
2022
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131. Development and Application of a Semi quantitative Scoring Method for Ultrastructural Assessment of Acute Stress in Pancreatic Islets

Author

Dyson, Nicola J., primary, Kattner, Nicole, additional, Honkanen-Scott, Minna, additional, Hunter, Bethany, additional, Doyle, Jennifer A., additional, White, Kathryn, additional, Davey, Tracey S., additional, Ploeg, Rutger J., additional, Bury, Yvonne A., additional, Tiniakos, Dina G., additional, Shaw, James A. M., additional, and Scott, William E., additional

Published
2021
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132. Comparison of SARS‐CoV ‐2 neutralizing antibody testing of convalescent plasma donations in the Netherlands and England: A pilot study

Author

Harvala, Heli, primary, Gopal, Robin, additional, Patel, Monika, additional, Zambon, Maria, additional, Roberts, David, additional, Lamikanra, Abigail, additional, Ploeg, Rutger, additional, Hoogerwerf, Marieke, additional, Zaaijer, Hans, additional, Hogema, Boris, additional, Reusken, Chantal, additional, van der Schoot, Ellen, additional, and Reimerink, Johan, additional

Published
2021
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133. Contributors to Volume 1

Author

Advani, Shailesh, Akdur, Aydincan, Arriola, Kimberly Jacob, Arunachalam, Priya, Axelrod, David, Balamurugan, Appakalai N., Batra, Ramesh, Beebe, David S., Bellin, Melena D., Benedetti, Enrico, Bhardi, Elissa, Birjiniuk, Joav, Boletis, Ioannis N., Brayman, Kenneth L., Bregman, Adam, Burton, Victoria, Caicedo, Juan Carlos, Callender, Clive O., Carpenter, Jennifer, Carpenter, Dustin J., Cherry, Mark J., Cooper, Matthew, Cronin, David C., II, Davis, LaShara, Davis, Earnest J., Delmonico, Francis L., Di Cocco, Pierpaolo, Dor, Frank J.M.F., Downs, Elissa M., Einecke, Gunilla, Emamaullee, Juliet, Erhardt, A.J., Fan, Pang Yen, Farney, Alan, Fratti, Alberto, Freedman, Barry I., Gaber, A.O., Gaines, Malendie T., Gallon, Lorenzo, Ghahramani, Nasrollah, Gill, John S., Gill, Justin, Glannon, Walter, Gruessner, Rainer W.G., Gruessner, Angelika C., Gürlüler, Ercüment, Gutmann, Thomas, Haase-Kromwijk, Bernadette J.J.M., Haberal, Mehmet, Hajjiri, Zahraa Fayez, Halloran, Philip F., Han, Duck J., Hebert, Sean A., Hemke, Aline C., Ho, Erica, Hoitsma, Andries J., Hughes, Nancy Scheper, Ibrahim, Hassan N., Jay, Colleen, Kahn, Jeffrey, Kaisar, Maria, Kamei, Hideya, Kandaswamy, Raja, Kaufman, Dixon B., Kenmochi, Takashi, Kittle, Haley, Kiuchi, Tetsuya, Klitenic, Samantha B., Knight, Richard J., Kocak, Burak, Kodipad, Ahad Ahmed, Kumar, Suresh, Laftavi, Mark R., Land, Walter G., Langer, Robert, Lebovitz, Evan E., Lee-Riddle, Grace S., Levan, Macey L., Leventhal, Joseph R., Liou, H. Peter, Lonze, Bonnie E., Madill-Thomsen, Katelynn S., Maluf, Daniel G., Maple, Hannah, Marinaki, Smaragdi, Mas, Valeria R., Matas, Arthur J., Mathew, James M., Matossian, Debora, Mena-Gutierrez, Alejandra M., Menser, Terri, Modi, Pranjal, Mokshagundam, Sri Prakash L., Montgomery, Robert A., Muench, Dorothy, Mulligan, David, Murad, Dina N., Murillo, Ariana, Nahi, Skylar L., Najarian (deceased), John S., Narayanan, Siddharth, Nathan, Jaimie D., Nguyen, Hana, Nguyen, Anh Vinh T., Nishio-Lucar, Angie, Norin, Allen J., Olausson, Michael, Onishi, Yasuharu, Pankewycz, Oleh G., Papalois, Vassilios, Pengel, Liset, Petrochenkov, Egor, Pirenne, Jacques, Ploeg, Rutger, Radcliffe-Richards, Janet, Ramanathan, Karthik, Ratner, Lloyd E., Reeves-Daniel, Amber M., Ross, Lainie Friedman, Rule, Andrew D., Sakai, Tetsuro, Sakuma, Yasunaru, Samaga, Krishna Kumar, Schold, Jesse D., Schroeter, Andreas, Seth, Abhinav, Shapiro, A. M. James, Shenoy, Surendra, Siegler, Mark, Spaggiari, Mario, Spak, Cedric W., Steiner, Robert, Stern, Jeffrey M., Subba Rao, Budithi, Tanabe, Kazunari, Tantisattamo, Ekamol, Thistlethwaite, J. Richard, Toledo, Alexander H., Troppmann, Christoph, Tullius, Stefan G., Tzvetanov, Ivo, Verghese, Priya S., Wadström, Jonas, Warburton, Karen, Waterman, Amy D., West-Thielke, Patricia, Wood, Emily H., Yi, Stephanie G., and Yu, Jennifer

Published
2024
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144. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial

Author

Besselink, Marc GH, van Santvoort, Hjalmar C, Buskens, Erik, Boermeester, Marja A, van Goor, Harry, Timmerman, Harro M, Nieuwenhuijs, Vincent B, Bollen, Thomas L, van Ramshorst, Bert, Witteman, Ben JM, Rosman, Camiel, Ploeg, Rutger J, Brink, Menno A, Schaapherder, Alexander FM, Dejong, Cornelis HC, Wahab, Peter J, van Laarhoven, Cees JHM, van der Harst, Erwin, van Eijck, Casper HJ, Cuesta, Miguel A, Akkermans, Louis MA, and Gooszen, Hein G

Published
2008
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149. Machine perfusion or cold storage in deceased-donor kidney transplantation

Author

Moers, Cyril, Smits, Jacqueline M., Maathuis, Mark-Hugo J., Treckmann, Jurgen, van Gelder, Frank, Napieralski, Bogdan P., van der Heide, Jaap J. Homan, Van Kasterop-Kutz, Margitta, Squifflet, Jean-Paul, van Heurn, Ernest, Kirste, Gunter R., Rahmel, Axel, Leuvenink, Henri G.D., Paul, Andreas, Pirenne, Jacques, and Ploeg, Rutger J.

Subjects
Homografts -- Usage, Homografts -- Health aspects, Preservation of organs, tissues, etc. -- Methods, Kidneys -- Transplantation, Kidneys -- Health aspects
Abstract

A study was conducted to evaluate whether hypothermic machine perfusion or cold storage of kidney allografts from deceased donors helps reduce risk of delayed graft function and increases graft survival after kidney transplantation. Results confirmed that hypothermic machine perfusion reduces risk and affords a better rate of survival for transplantation patients in the first year after transplantation.

Published
2009

150. Development of ex situ normothermic reperfusion as an innovative method to assess pancreases after preservation

Author

Ogbemudia, Ann Etohan, primary, Hakim, Gabriella, additional, Dengu, Fungai, additional, El‐Gilani, Faysal, additional, Dumbill, Richard, additional, Mulvey, John, additional, Sayal, Karen, additional, Prudhomme, Thomas, additional, Mesnard, Benoit, additional, Rozenberg, Kaithlyn, additional, Lo Faro, Letizia, additional, James, Timothy, additional, Oliver, Joshua, additional, Sharples, Edward, additional, Mittal, Shruti, additional, Johnson, Paul, additional, Friend, Peter J., additional, Ploeg, Rutger, additional, Hunter, James, additional, and Branchereau, Julien, additional

Published
2021
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