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Your search keyword '"Pillai, Radhakrishna G."' showing total 121 results
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121 results on '"Pillai, Radhakrishna G."'

115. Portable Bio-electric Plant

Author

James, M Geo, Suresh, Subin, Abraham, Nikil Thomas, Sitharam, T G, Editor-in-Chief, Drück, Harald, editor, Pillai, Radhakrishna G., editor, Tharian, Manoj G, editor, and Majeed, Aysha Zeneeb, editor

Published
2019
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120. Thixotropic effects during large-scale concrete pump tests on site

Author

De Schutter, Geert, Santhanam, Manu, Gettu, Ravindra, Pillai, Radhakrishna G., and Nayar, Sunitha K.

Subjects
Technology and Engineering, pumping, rheology, thixotropy, Concrete
Abstract

During recent years, the fundamentals of pumping fresh concrete have been intensively studied worldwide. New insights have been gained concerning the important role of the lubrication layer near the surface pipe. The influence of rheological properties of the fresh concrete, like yield stress, viscosity, and shear thickening behavior, is now well understood, and can be fairly accurately modelled. One major challenge is found in the potential effect of thixotropy while pumping fresh concrete, especially in case the pumping operation is temporarily paused and resumed after a while. Due to thixotropic effects, restarting the pumping operation can be a very challenging task. This paper reports on a large-scale concrete pump test on a construction site, specifically focusing on the risk of thixotropy. Fresh concrete has been pumped in a horizontal closed-loop pumping pipe with a total length of 600 meter. In steady-state pumping conditions, the pumping operation was very successful, and in agreement with the expectations. However, the thixotropic effects, occurring during a short stop of the pumping operations, showed to provoke major problems while trying to resume pumping. The lessons-learnt helped to define a successful pumping procedure for this major construction site.

Published
2017

121. Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945.

Author

Pillai RG, Forster M, Perumal M, Mitchell F, Leyton J, Aibgirhio FI, Golovko O, Jackman AL, and Aboagye EO

Subjects
Animals, Chemistry, Pharmaceutical methods, Female, Fluorodeoxyglucose F18 pharmacology, Folate Receptor 1, Folate Receptors, GPI-Anchored, Humans, Mice, Mice, Inbred BALB C, Neoplasm Transplantation, Positron-Emission Tomography methods, Time Factors, Biomarkers, Tumor metabolism, Carrier Proteins metabolism, Quinazolines pharmacology, Receptors, Cell Surface metabolism, Thymidylate Synthase antagonists & inhibitors
Abstract

The assessment of tissue-specific pharmacodynamics is desirable in the development of tumor-targeted therapies. Plasma deoxyuridine (dUrd) levels, a measure of systemic thymidylate synthase (TS) inhibition, has limited application for studying the pharmacodynamics of novel TS inhibitors targeted to the high affinity alpha-folate receptor (FR). Here, we have evaluated the utility of [(18)F]fluorothymidine positron emission tomography ([(18)F]FLT-PET) for imaging the tissue pharmacodynamics of BGC 945, an FR-targeted antifolate TS inhibitor; the nontargeted antifolate BGC 9331 was used for comparison. TS inhibition by both drugs induced a concentration-dependent increase in [(3)H]thymidine uptake in FR-positive human epidermoid KB cells. Membrane-associated equilibrative nucleoside transporter type 1 levels increased from 55,720 +/- 6,101 to 118,700 +/- 5,193 and 130,800 +/- 10,800 per cell at 100 mug/mL of BGC 9331 and BGC 945, respectively, suggesting this as a potential mechanism of increased nucleoside uptake. In keeping with these in vitro findings, tumor [(18)F]FLT accumulation in KB xenografts increased by >/=2-fold after drug treatment with maximal levels at 1 to 4 hours and 4 to 24 hours after BGC 9331 and BGC 945 treatment, respectively. Of interest to FR targeting, BGC 9331, but not BGC 945, induced accumulation of [(18)F]FLT uptake in intestine, a proliferative and TS-responsive tissue. For both drugs, quantitative changes in tumor [(18)F]FLT uptake were associated with increased tumor dUrd levels. In conclusion, we have validated the utility of [(18)F]FLT-PET to image TS inhibition induced by antifolates and shown the tumor-specific activity of BGC 945. This imaging biomarker readout will be useful in the early clinical development of BGC 945.

Published
2008
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