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Ganglioside-induced differentiation associated-protein 1 (GDAP1) mutations are commonly associated with autosomal recessive Charcot-Marie-Tooth (ARCMT) neuropathy; however, in rare instances, they also lead to autosomal dominant Charcot-Marie-Tooth (ADCMT). We aimed to investigate the frequency of disease-causing heterozygous GDAP1mutations in ADCMT and their associated phenotype.

High energy synchrotron X-ray diffraction, transmission electron microscopy and mechanical testing were employed to investigate the evolution of microstructure, texture and functional superelastic properties of 0.1 mm thin as drawn Ni–Tiwires subjected to a nonconventional heat treatment by controlled electric current (FTMT-EC method). As drawn Ni–Tiwires were prestrained in tension and exposed to a sequence of short DC power pulses in the millisecond range. The annealing time in the FTMT-EC processing can be very short but the temperature and force could be very high compared to the conventional heat treatment of SMAs. It is shown that the heavily strained, partially amorphous microstructure of the as drawn Ni–Tiwire transforms under the effect of the DC pulse and tensile stress into a wide range of annealed nanosized microstructures depending on the pulse time. The functional superelastic properties and microstructures of the FTMT-EC treated Ni–Tiwire are comparable to those observed in straight annealed wires.

In order to better understand the unique functional responses of shape memory alloys, improve the currently existing SMA modeling tools and used them beneficially in smart structure applications, it is desirable to investigate the deformation/transformation processes in these materials in action – i.e. under stress and temperature variation. In this work, an overview is presented on the applications of various recently developed or originally employed in-situ experimental methods and approaches to martensitic transformations in SMAs.

In order to better understand the unique functional responses of shape memory alloys, improve the currently existing SMA modeling tools and used them beneficially in smart structure applications, it is desirable to investigate the deformation/transformation processes in these materials in action – i.e. under stress and temperature variation. In this work, an overview is presented on the applications of various recently developed or originally employed in-situ experimental methods and approaches to martensitic transformations in SMAs.