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565 results on '"Piattelli M"'

124. A randomized controlled trial of pegylated interferonα-2a (40 KD) or interferonα-2a plus ribavirin and amantadinevsinterferonα-2a and ribavirin in treatment-naïve patients with chronic hepatitis C.

Author

Mangia, A., Ricci, G. L., Persico, M., Minerva, N., Carretta, V., Bacca, D., Cela, M., Piattelli, M., Annese, M., Maio, G., Conte, D., Guadagnino, V., Pazienza, V., Festi, D., Spirito, F., and Andriulli, A.

Subjects
HEPATITIS C virus, AMANTADINE, RIBAVIRIN, INTERFERONS, ANTIVIRAL agents, HEPATITIS C, IMMUNOTHERAPY
Abstract

We determined whether triple therapy comprising amantadine (AMA), ribavirin (RBV) and either peginterferon (PEG-IFN)α-2a or conventional IFNα-2a would improve sustained virological response (SVR) rates over dual therapy with IFNα-2a and RBV in patients with chronic HCV infection. A total of 362 treatment-naïve patients were randomized to 48 weeks of treatment with: PEG-IFNα-2a 180 μg/week (group A) or IFNα-2a 3 MU tiw (groups B and C). All patients received RBV 1000 or 1200 mg/day and those in groups A and B received AMA 200 mg/day. SVR was defined as an undetectable HCV RNA after 24 weeks of untreated follow-up. At the end of therapy, 74.4% (95% CI 0.66–0.82) of patients in group A were HCV RNA-negative compared with 42.5% (95% CI 0.33–0.50) of those in group B (P = 0.0001) and 48.8% (95% CI 0.40–0.56) of those in group C. SVR was achieved in a significantly greater proportion of patients in group A compared with groups B and C: 65.3% (95% CI 0.53–0.56), 33.3% (95% CI 0.25–0.41) and 44.6% (95% CI 0.36–0.53;P = 0.0001) respectively. In patients with genotype 1, SVR rates were 55.2, 22.8 and 28.8% with the three regimens respectively. Factors independently associated with SVR were HCV genotype 2 or 3, therapy with PEG-IFN, female gender and age. In treatment-naïve patients with chronic hepatitis C, triple therapy with PEG-IFNα-2a, RBV and AMA produces higher SVR than dual or triple therapy with conventional IFNα-2a. [ABSTRACT FROM AUTHOR]

Published
2005
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129. Aminoacids, sugar and sterols of some mediterraneau brown algae

Author

AMICO V., ORIENTE G., PIATTELLI M., TRINGALI C., FATTORUSSO E., MAGNO S., SANTACROCE C., SICA D., MAYOL, LUCIANO, Amico, V., Oriente, G., Piattelli, M., Tringali, C., Fattorusso, E., Magno, S., Mayol, Luciano, Santacroce, C., and Sica, D.

Published
1976

131. Futher perhydrazulene diterpenes from marine organisms

Author

DANISE B., MINALE L., RICCIO R., AMICO V., ORIENTE G., PIATTELLI M., TRINGALI C., FATTORUSSO E., MAGNO S., MAYOL, LUCIANO, Danise, B., Minale, L., Riccio, R., Amico, V., Oriente, G., Piattelli, M., Tringali, C., Fattorusso, E., Magno, S., and Mayol, Luciano

Published
1977

139. Absolute Configuration of Some Marine Metabolites from Cystoseira spp.

Author

Amico, V., Piattelli, M., Bizzini, M., and Neri, P.

Abstract

The absolute configuration of meroditerpenoid metabolites isolated from Mediterranean brown algae of the genus Cystoseira has been determined using a recent modification of Mosher's method. The data obtained suggest that the compounds examined are interconnected through a stereocontrolled enzymatic reaction. This constitutes another confirmatory step in the validation of a previously proposed biosynthetic pathway for Cystoseira metabolites.

Published
1997

141. Previously unreported p-terphenyl derivatives with antibiotic properties from the fruiting bodies of Sarcodonleucopus(Basidiomycetes). A two-dimensional nuclear magnetic resonance study

Author

Tringali, C., Piattelli, M., Geraci, C., Nicolosi, G., and Rocco, C.

Abstract

Two previously unreported antibiotic metabolites, 2′,3′,4″-triacetoxy-3,4,5′,6′-tetrahydroxy-p-terphenyl (10) and 2′,3′-diacetoxy-3,4,5′,6′,4″-pentahydroxy-p-terphenyl (11), have been isolated from the basidiomycete Sarcodonleucopus. Their structures have been determined by chemical transformations and spectral analysis, including heteronuclear two-dimensional nuclear magnetic resonance methods.

Published
1987
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