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712 results on '"Phipps, Simon"'

105. RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD

Author

Allam, Venkata Sita Rama Raju, primary, Faiz, Alen, additional, Lam, Maggie, additional, Rathnayake, Senani N. H., additional, Ditz, Benedikt, additional, Pouwels, Simon D., additional, Brandsma, Corry‐Anke, additional, Timens, Wim, additional, Hiemstra, Pieter S., additional, Tew, Gaik W., additional, Neighbors, Margaret, additional, Grimbaldeston, Michele, additional, van den Berge, Maarten, additional, Donnelly, Sheila, additional, Phipps, Simon, additional, Bourke, Jane E., additional, and Sukkar, Maria B., additional

Published
2020
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108. HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

Author

Loh, Zhixuan, primary, Simpson, Jennifer, additional, Ullah, Ashik, additional, Zhang, Vivian, additional, Gan, Wan J., additional, Lynch, Jason P., additional, Werder, Rhiannon B., additional, Sikder, Al Amin, additional, Lane, Katie, additional, Sim, Choon Boon, additional, Porrello, Enzo, additional, Mazzone, Stuart B., additional, Sly, Peter D., additional, Steptoe, Raymond J., additional, Spann, Kirsten M., additional, Sukkar, Maria B., additional, Upham, John W., additional, and Phipps, Simon, additional

Published
2020
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109. Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells

Author

Simpson, Jennifer, primary, Loh, Zhixuan, additional, Ullah, Md Ashik, additional, Lynch, Jason P., additional, Werder, Rhiannon B., additional, Collinson, Natasha, additional, Zhang, Vivian, additional, Dondelinger, Yves, additional, Bertrand, Mathieu J. M., additional, Everard, Mark L., additional, Blyth, Christopher C., additional, Hartel, Gunter, additional, Van Oosterhout, Antoon J., additional, Gough, Peter J., additional, Bertin, John, additional, Upham, John W., additional, Spann, Kirsten M., additional, and Phipps, Simon, additional

Published
2020
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110. Shockwave Lithotripsy Is an Efficacious Treatment Modality for Obese Patients with Upper Ureteral Calculi: Logistic Regression and Matched-Pair Analyses from a Dedicated Center Comparing Treatment Outcomes by Skin-to-Stone Distance

Author

Mains, Edward A.A., primary, Blackmur, James P., additional, Sharma, Abhishek D., additional, Gietzmann, William K., additional, El-Mokadem, Ismail, additional, Stephenson, Carolann, additional, Wallace, Shirley, additional, Phipps, Simon, additional, Thomas, Ben G., additional, Tolley, David A., additional, and Cutress, Mark L., additional

Published
2020
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111. A Simple Clinical Tool for Stratifying Risk of Clinically Significant CKD after Nephrectomy: Development and Multinational Validation

Author

Ellis, Robert J., primary, Del Vecchio, Sharon J., additional, Gallagher, Kevin M.J., additional, Aliano, Danielle N., additional, Barber, Neil, additional, Bolton, Damien M., additional, Chew, Etienne T.S., additional, Coombes, Jeff S., additional, Coory, Michael D., additional, Davis, Ian D., additional, Donaldson, James F., additional, Francis, Ross S., additional, Giles, Graham G., additional, Gobe, Glenda C., additional, Hawley, Carmel M., additional, Johnson, David W., additional, Laird, Alexander, additional, Leung, Steve, additional, Malki, Manar, additional, Marco, David J.T., additional, McNeill, Alan S., additional, Neale, Rachel E., additional, Ng, Keng L., additional, Phipps, Simon, additional, Stewart, Grant D., additional, White, Victoria M., additional, Wood, Simon T., additional, and Jordan, Susan J., additional

Published
2020
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121. Why snafus like HP's keylogger will happen again

Author

Phipps, Simon

Subjects
Hewlett-Packard Co. -- Safety and security measures, Notebook computers -- Safety and security measures, Laptop computers -- Safety and security measures, Computer industry -- Safety and security measures, Access control (Computers) -- Safety and security measures, Laptop/portable computer, Microcomputer industry, Network access, Computer industry, Computers and office automation industries
Abstract

Byline: Simon Phipps As Woody Leonhard explained last week, HP laptops have come with a little added extra ever since Christmas 2015: a keylogger. HP has confirmed to me that [...]

Published
2017

122. A simple clinical tool for stratifying risk of clinically significant CKD after nephrectomy: development and multinational validation

Author

Ellis, Robert J., Del Vecchio, Sharon J., Gallagher, Kevin M.J., Aliano, Danielle N., Barber, Neil, Bolton, Damien M., Chew, Etienne T.S., Coombes, Jeff S., Coory, Michael D., Davis, Ian D., Donaldson, James F., Francis, Ross S., Giles, Graham G., Gobe, Glenda C., Hawley, Carmel M., Johnson, David W., Laird, Alexander, Leung, Steve, Malki, Manar, Marco, David J.T., McNeill, Alan S., Neale, Rachel E., Ng, Keng L., Phipps, Simon, Stewart, Grant D., White, Victoria M., Wood, Simon T., Jordan, Susan J., Ellis, Robert J., Del Vecchio, Sharon J., Gallagher, Kevin M.J., Aliano, Danielle N., Barber, Neil, Bolton, Damien M., Chew, Etienne T.S., Coombes, Jeff S., Coory, Michael D., Davis, Ian D., Donaldson, James F., Francis, Ross S., Giles, Graham G., Gobe, Glenda C., Hawley, Carmel M., Johnson, David W., Laird, Alexander, Leung, Steve, Malki, Manar, Marco, David J.T., McNeill, Alan S., Neale, Rachel E., Ng, Keng L., Phipps, Simon, Stewart, Grant D., White, Victoria M., Wood, Simon T., and Jordan, Susan J.

Published
2020

123. HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

Author

Loh, Zhixuan, Simpson, Jennifer, Ullah, Ashik, Zhang, Vivian, Gan, Wan J., Lynch, Jason P., Werder, Rhiannon B., Sikder, Al Amin, Lane, Katie, Sim, Choon Boon, Porrello, Enzo, Mazzone, Stuart B., Sly, Peter D., Steptoe, Raymond J., Spann, Kirsten M., Sukkar, Maria B., Upham, John W., Phipps, Simon, Loh, Zhixuan, Simpson, Jennifer, Ullah, Ashik, Zhang, Vivian, Gan, Wan J., Lynch, Jason P., Werder, Rhiannon B., Sikder, Al Amin, Lane, Katie, Sim, Choon Boon, Porrello, Enzo, Mazzone, Stuart B., Sly, Peter D., Steptoe, Raymond J., Spann, Kirsten M., Sukkar, Maria B., Upham, John W., and Phipps, Simon

Abstract

Type-2 immunity elicits tissue repair and homeostasis, however dysregulated type-2 responses cause aberrant tissue remodelling, as observed in asthma. Severe respiratory viral infections in infancy predispose to later asthma, however, the processes that mediate tissue damage-induced type-2 inflammation and the origins of airway remodelling remain illdefined. Here, using a preclinical mouse model of viral bronchiolitis, we find that increased epithelial and mesenchymal high-mobility group box 1 (HMGB1) expression is associated with increased numbers of IL-13-producing type-2 innate lymphoid cell (ILC2s) and the expansion of the airway smooth muscle (ASM) layer. Anti-HMGB1 ablated lung ILC2 numbers and ASM growth in vivo, and inhibited ILC2-mediated ASM cell proliferation in a co-culture model. Furthermore, we identified that HMGB1/RAGE (receptor for advanced glycation endproducts) signalling mediates an ILC2-intrinsic IL-13 auto-amplification loop. In summary, therapeutic targeting of the HMGB1/RAGE signalling axis may act as a novel asthma preventative by dampening ILC2-mediated type-2 inflammation and associated ASM remodelling.

Published
2020

124. Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells

Author

Simpson, Jennifer, Loh, Zhixuan, Ullah, Md Ashik, Lynch, Jason P., Werder, Rhiannon B., Collinson, Natasha, Zhang, Vivian, Dondelinger, Yves, Bertrand, Mathieu J.M., Everard, Mark L., Blyth, Christopher C., Hartel, Gunter, Van Oosterhout, Antoon J., Gough, Peter J., Bertin, John, Upham, John W., Spann, Kirsten M., Phipps, Simon, Simpson, Jennifer, Loh, Zhixuan, Ullah, Md Ashik, Lynch, Jason P., Werder, Rhiannon B., Collinson, Natasha, Zhang, Vivian, Dondelinger, Yves, Bertrand, Mathieu J.M., Everard, Mark L., Blyth, Christopher C., Hartel, Gunter, Van Oosterhout, Antoon J., Gough, Peter J., Bertin, John, Upham, John W., Spann, Kirsten M., and Phipps, Simon

Abstract

Rationale: Respiratory syncytial virus (RSV) bronchiolitis causes significant infant mortality. Bronchiolitis is characterized by airway epithelial cell (AEC) death; however, the mode of death remains unknown. Objectives: To determine whether necroptosis contributes to RSV bronchiolitis pathogenesis via HMGB1 (high mobility group box 1) release. Methods: Nasopharyngeal samples were collected from children presenting to the hospital with acute respiratory infection. Primary humanAECs andneonatalmicewere inoculatedwithRSVandmurine Pneumovirus, respectively. Necroptosis was determined via viability assays and immunohistochemistry for RIPK1 (receptor-interacting protein kinase-1), MLKL (mixed lineage kinase domain-like pseudokinase) protein, and caspase-3. Necroptosis was blocked using pharmacological inhibitors and RIPK1 kinase-dead knockin mice. Measurements and Main Results: HMGB1 levels were elevated in nasopharyngeal samples of children with acute RSV infection. RSV-induced epithelial cell death was associated with increased phosphorylated RIPK1 and phosphorylated MLKL but not active caspase-3 expression. Inhibition of RIPK1 or MLKL attenuated RSV-induced HMGB1 translocation and release, and lowered viral load. MLKL inhibition increased active caspase-3 expression in a caspase-8/9 dependent manner. In susceptible mice, Pneumovirus infection upregulated RIPK1 and MLKL expression in the airway epithelium at 8 to 10 days after infection, coinciding with AEC sloughing, HMGB1 release, and neutrophilic inflammation. Genetic or pharmacological inhibition of RIPK1 or MLKL attenuated these pathologies, lowered viral load, and prevented type 2 inflammation and airway remodeling. Necroptosis inhibition in early life ameliorated asthma progression induced by viral or allergen challenge in later life. Conclusions: Pneumovirus infection induces AEC necroptosis. Inhibition of necroptosis may be a viable strategy to limit the severity of viral bronchiolitis and break its nexus

Published
2020

134. PAG1 limits allergen‐induced type 2 inflammation in the murine lung

Author

Ullah, Md Ashik, primary, Vicente, Cristina T., additional, Collinson, Natasha, additional, Curren, Bodie, additional, Sikder, Md Al Amin, additional, Sebina, Ismail, additional, Simpson, Jennifer, additional, Varelias, Antiopi, additional, Lindquist, Jonathan A., additional, Ferreira, Manuel A. R., additional, and Phipps, Simon, additional

Published
2019
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135. Open source uproar as MariaDB goes commercial

Author

Phipps, Simon

Subjects
DBMS software -- Marketing, DBMS, Company marketing practices, DBMS utility, Computers and office automation industries, MariaDB 2.0 (DBMS) -- Marketing
Abstract

Byline: Simon Phipps MariaDB Corp. has announced that release 2.0 of its MaxScale database proxy software is henceforth no longer open source. The organization has made it source-available under a [...]

Published
2016

136. Microsoft loves open source? Only when it's convenient

Author

Phipps, Simon

Subjects
Microsoft Corp. -- Evaluation, Open source software -- Usage -- Social aspects, Software industry -- Evaluation, Open source software, Computers and office automation industries
Abstract

Byline: Simon Phipps Its been a big month for Microsoft and open source. The company joined the Eclipse project and open-sourced some plug-in code. It announced SQL Server will be [...]

Published
2016

137. The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy

Author

McLay, Iain M., Halley, Frank, Souness, John E., McKenna, Jeffrey, Benning, Veronique, Birrell, Mark, Burton, Brenda, Belvisi, Maria, Collis, Alan, Constan, Alex, Foster, Martyn, Hele, David, Jayyosi, Zaid, Kelley, Mike, Maslen, Chris, Miller, Glen, Ouldelhkim, Marie-Claude, Page, Kenneth, Phipps, Simon, Pollock, Kenneth, Porter, Barry, Ratcliffe, Andrew J., Redford, Elisabeth J., Webber, Stephen, Slater, Bryan, Thybaud, Veronique, and Wilsher, Nicola

Published
2001
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138. RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD.

Author

Allam, Venkata Sita Rama Raju, Faiz, Alen, Lam, Maggie, Rathnayake, Senani N. H., Ditz, Benedikt, Pouwels, Simon D., Brandsma, Corry‐Anke, Timens, Wim, Hiemstra, Pieter S., Tew, Gaik W., Neighbors, Margaret, Grimbaldeston, Michele, van den Berge, Maarten, Donnelly, Sheila, Phipps, Simon, Bourke, Jane E., and Sukkar, Maria B.

Subjects
ADVANCED glycation end-products, OBSTRUCTIVE lung diseases, AIRWAY (Anatomy), SMOKING
Abstract

Background: The receptor for advanced glycation end products (RAGE) and Toll‐like receptor 4 (TLR4) is implicated in COPD. Although these receptors share common ligands and signalling pathways, it is not known whether they act in concert to drive pathological processes in COPD. We examined the impact of RAGE and/or TLR4 gene deficiency in a mouse model of COPD and also determined whether expression of these receptors correlates with airway neutrophilia and airway hyperresponsiveness (AHR) in COPD patients. Methods: We measured airway inflammation and AHR in wild‐type, RAGE−/−, TLR4−/− and TLR4−/−RAGE−/− mice following acute exposure to cigarette smoke (CS). We also examined the impact of smoking status on AGER (encodes RAGE) and TLR4 bronchial gene expression in patients with and without COPD. Finally, we determined whether expression of these receptors correlates with airway neutrophilia and AHR in COPD patients. Results: RAGE−/− mice were protected against CS‐induced neutrophilia and AHR. In contrast, TLR4−/− mice were not protected against CS‐induced neutrophilia and had more severe CS‐induced AHR. TLR4−/−RAGE−/− mice were not protected against CS‐induced neutrophilia but were partially protected against CS‐induced mediator release and AHR. Current smoking was associated with significantly lower AGER and TLR4 expression irrespective of COPD status, possibly reflecting negative feedback regulation. However, consistent with preclinical findings, AGER expression correlated with higher sputum neutrophil counts and more severe AHR in COPD patients. TLR4 expression did not correlate with neutrophilic inflammation or AHR. Conclusions: Inhibition of RAGE but not TLR4 signalling may protect against airway neutrophilia and AHR in COPD. [ABSTRACT FROM AUTHOR]

Published
2021
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139. VCs who miss the point of open source shouldn't fund it

Author

Phipps, Simon

Subjects
Venture capital companies -- Investments, Venture capital -- Forecasts and trends, Open source software -- Forecasts and trends -- Economic aspects, Market trend/market analysis, Venture capital, Company investment, Open source software, Computers and office automation industries
Abstract

Byline: Simon Phipps A recent article on TechCrunch provides some worrying insight into the question of the worldview of VC investors in open source businesses. The authors have impeccable credentials. [...]

Published
2016

140. Red Hat and Microsoft cozy up in the Azure cloud

Author

Phipps, Simon

Subjects
Linux (Operating system), Middleware, Linux (Operating system), Middleware, Database middleware, Computers and office automation industries
Abstract

Byline: Simon Phipps It apparently took nearly two years to negotiate, but the sound of a crisp frost was heard in hell this morning as Microsoft and Red Hat announced [...]

Published
2015

141. Sad day for developers: SCOTUS denies Google's appeal on APIs

Author

Phipps, Simon

Subjects
Computers and office automation industries
Abstract

Byline: Simon Phipps In an unsurprising ruling today, the Supreme Court balanced a little of the good it did last week by denying Google's appeal against Oracle in the matter [...]

Published
2015

142. LibreOffice debuts in the Mac App Store

Author

Phipps, Simon

Subjects
Computers and office automation industries
Abstract

Byline: Simon Phipps After years of manual installs and manual updates, open source flagship office suite LibreOffice is now available for installation by Mac users via Apples Mac App Store. [...]

Published
2015

143. Questions loom over 'open source' Swift

Author

Phipps, Simon

Subjects
Computers and office automation industries
Abstract

Byline: Simon Phipps Apples decision to open-source Swift at WWDC surprised some people (though others described it as table stakes). What does it mean for a programming language to be [...]

Published
2015

144. SourceForge commits reputational suicide

Author

Phipps, Simon

Subjects
Malware, Computers and office automation industries
Abstract

Byline: Simon Phipps The venerable project hosting service SourceForge may have finally crossed the line into irrelevance following an abuse of trust related to the GIMP project. Once the darling [...]

Published
2015

145. Oracle v. Google: We're not screwed yet

Author

Phipps, Simon

Subjects
Copyrights, Patent/copyright issue, Computers and office automation industries
Abstract

Byline: Simon Phipps It may have fallen off the radar, but the dispute between Oracle and Google over Android and Java continues. This week saw the delivery of the amicus [...]

Published
2015

146. Google stomps on scammers -- and helps open source

Author

Phipps, Simon

Subjects
Malware, Open source software, Open source software, Computers and office automation industries
Abstract

Byline: Simon Phipps Scammers masquerading their malware as genuine open source downloads may finally face a new challenge finding Windows users to victimize. At the end of April, Google quietly [...]

Published
2015

147. The rise and rise of open source

Author

Phipps, Simon

Subjects
Open source software -- Surveys, Open source software, Computers and office automation industries
Abstract

Byline: Simon Phipps The results from the annual Future Of Open Source survey are in, and they confirm everything we already knew: Open source is now the default. The survey [...]

Published
2015

148. Open source patent protection extended to popular software

Author

Phipps, Simon

Subjects
Patents, Patent law, Patent/copyright issue, Computers and office automation industries
Abstract

Byline: Simon Phipps OIN (the Open Invention Network) has announced important changes to its definition of what constitutes the Linux system.' Licensing community participants were advised yesterday that, as of [...]

Published
2015

149. Facebook gives in on patent grant

Author

Phipps, Simon

Subjects
Patents, Patent law, Patent/copyright issue, Computers and office automation industries
Abstract

Byline: Simon Phipps Late Friday, Facebook announced it's finally giving in to pressure from the open source community and fixed its open source patent grant. While most people felt the [...]

Published
2015

150. Open source is better off without FoundationD

Author

Phipps, Simon

Subjects
Middleware, Middleware, Database middleware, Computers and office automation industries
Abstract

Byline: Simon Phipps Database startup FoundationDB mysteriously vanished at the end of last month, along with both the downloads of its proprietary database and its open source projects. As it [...]

Published
2015

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