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101. Restitution of the K and F Components of the Solar Corona from LASCO-C2 Images over 24 Years [1996--2019]

Author: Hugo Gilardy, A. Llebaria, Philippe Lamy, Jean Loirat, Brice Boclet, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), HELIOS - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), and Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)
Subjects: 010504 meteorology & atmospheric sciences, K-corona, Polarimetry, FOS: Physical sciences, 01 natural sciences, law.invention, law, 0103 physical sciences, 010303 astronomy & astrophysics, Coronagraph, Solar and Stellar Astrophysics (astro-ph.SR), 0105 earth and related environmental sciences, Remote sensing, Physics, Sunspot, Pixel, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Stray light, Astronomy and Astrophysics, Corona, Data set, F-corona, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Radiance
Abstract: We present a photometrically accurate restitution of the K and F coronae from white-light images obtained over 24 Years [1996--2019] by the Large-Angle Spectrometric COronagraph "LASCO-C2" onboard the Solar and Heliospheric Observatory (SOHO). The procedure starts with the data set coming from the polarimetric separation of images of 512 x 512 pixels in which the F-corona and the instrumental stray light are entangled. Disentangling these components proceeds in three stages, each composed of several steps. Stage 1 establishes the distinct variations of the radiance of these components with the Sun--SOHO distance and generate a new data set of median images calculated for each Carrington rotation. Stage 2 achieves the restitution of a set of 36 stray light images reflecting its temporal variation and the periodic rolls of SOHO which started in 2003. Stage 3 achieves the restitution of the F-corona and a time series of daily images is generated. These results allowed us processing the whole set of routine LASCO-C2 images of 1024 x 1024 pixels (approximately 626000 images) and producing calibrated, high resolution images of the K-corona. We extend our past conclusions that the temporal variation of the integrated radiance of the K-corona tracks the solar activity over two solar cycles 23 and 24 and that it is highly correlated with the temporal variation of the total magnetic field. The behaviours of the integrated radiance during the last few years of the declining phases of solar cycles 23 and 24 are remarkably similar, reaching the same floor level and leading to a duration of 11.0 year for the latter cycle, in agreement with the sunspot determination., 1. Added two new Sections 3.5 and 4.2 discussing uncertainties, with new Figures (21 and 23); results unchanged. 2. Added a comparison with the results of Hayes et al. (2001) in Fig. 24
Published: 2020

102. Pervasive chromosomal instability and karyotype order in tumour evolution

Author: Lars Dyrskjøt, Andrew Rowan, Priscilla K. Brastianos, Stuart Horswell, Wei-Ting Lu, Gareth A. Wilson, Mickael Escudero, Francesc Castro-Giner, David Allan Moore, Thanos P. Mourikis, Iver Nordentoft, Dhruva Biswas, Katja Harbst, Ian Tomlinson, Fabrice Andre, Lucy R. Yates, Kerstin Haase, Neeltje Steeghs, Michelle Dietzen, Thomas B.K. Watkins, Raymond J. Cho, Hang Xu, Nicholas McGranahan, Boris C. Bastian, Zoltan Szallasi, Fanny Jaulin, Kevin Litchfield, Peter Savas, Marina Petkovic, Franco Caramia, Jonas Demeulemeester, Philippe Lamy, Lavinia Spain, Stefan C. Dentro, Sergi Elizalde, Emilia L. Lim, Lewis Au, Maise Al Bakir, Eva Grönroos, Sally M. Dewhurst, Sherene Loi, Charles Swanton, George D. Cresswell, Mariam Jamal-Hanjani, Samra Turajlic, Göran Jönsson, Nicolai Juul Birkbak, Cecile Vicier, Samuel F. Bakhoum, Vivianne C. G. Tjan-Heijnen, Peter Van Loo, Nicholas M. Luscombe, Peter J. Campbell, Rachel Rosenthal, Roland F. Schwarz, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), and RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
Subjects: Male, 0301 basic medicine, Loss of Heterozygosity, Chromosomes, Human, Pair 11/genetics, SCNA, Chromosomal Instability/genetics, Loss of heterozygosity, 0302 clinical medicine, Neoplasms, Chromosome instability, Pair 11, Neoplasm Metastasis, Neoplasm Metastasis/genetics, Oncogene Proteins, Multidisciplinary, Karyotype, Neoplasms/genetics, CANCER, Clone Cells/metabolism, Oncogene Proteins/genetics, 030220 oncology & carcinogenesis, Pair 8, Female, Ploidy, Human, Chromosomes, Human, Pair 8, EXPRESSION, GENES, DNA Copy Number Variations, Evolution, General Science & Technology, Locus (genetics), Human leukocyte antigen, DNA Copy Number Variations/genetics, Biology, Chromosomes, Article, Evolution, Molecular, 03 medical and health sciences, Chromosomal Instability, Cyclin E, Genetics, Humans, IDENTIFICATION, Loss of Heterozygosity/genetics, Chromosomes, Human, Pair 11, Human Genome, Molecular, Chromosome, Chromosomes, Human, Pair 8/genetics, Clone Cells, MODEL, 030104 developmental biology, Mutagenesis, METASTASIS, Cancer research, PATTERNS, Cyclin E/genetics
Abstract: Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes(1,2). The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary for tumour evolution(1,3,4). Here we use multi-sample phasing and SCNA analysis of 1,421 samples from 394 tumours across 22 tumour types to show that continuous chromosomal instability results in pervasive SCNA heterogeneity. Parallel evolutionary events, which cause disruption in the same genes (such asBCL9, MCL1,ARNT(also known asHIF1B),TERTandMYC) within separate subclones, were present in 37% of tumours. Most recurrent losses probably occurred before whole-genome doubling, that was found as a clonal event in 49% of tumours. However, loss of heterozygosity at the human leukocyte antigen (HLA) locus and loss of chromosome 8p to a single haploid copy recurred at substantial subclonal frequencies, even in tumours with whole-genome doubling, indicating ongoing karyotype remodelling. Focal amplifications that affected chromosomes 1q21 (which encompassesBCL9, MCL1andARNT), 5p15.33 (TERT), 11q13.3 (CCND1), 19q12 (CCNE1) and 8q24.1 (MYC) were frequently subclonal yet appeared to be clonal within single samples. Analysis of an independent series of 1,024 metastatic samples revealed that 13 focal SCNAs were enriched in metastatic samples, including gains in chromosome 8q24.1 (encompassingMYC) in clear cell renal cell carcinoma and chromosome 11q13.3 (encompassingCCND1) in HER2(+)breast cancer. Chromosomal instability may enable the continuous selection of SCNAs, which are established as ordered events that often occur in parallel, throughout tumour evolution.Chromosomal instability enables the continuous selection of somatic copy number alterations, which are established as ordered events that often occur in parallel, throughout tumour evolution and metastasis.
Published: 2020

103. Binary asteroid (31) Euphrosyne: ice-rich and nearly spherical

Author: Emmanuel Jehin, Josef Hanus, Christophe Dumas, Franck Marchis, Frédéric Vachier, Nicolas Rambaux, Pierre Vernazza, Romain Fétick, Marin Ferrais, Zouhair Benkhaldoun, M. Pajuelo, Paolo Tanga, Bin Yang, A. Marciniak, Olivier Witasse, Matti Viikinkoski, E. Podlewska-Gaca, Fabrice Cipriani, Ondrej Chrenko, Philippe Lamy, Laurent Jorda, François Colas, J. Grice, Tadeusz Michalowski, Julie Castillo-Rogez, Josef Ďurech, Mikko Kaasalainen, Grzegorz Dudziński, Michael Marsset, Patrick Michel, Mirel Birlan, Przemyslaw Bartczak, Alexis Drouard, Toni Santana-Ros, Jérôme Berthier, Miroslav Brož, Arthur Vigan, P. Ševeček, Benoit Carry, Thierry Fusco, Agnieszka Kryszczyńska, European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), Institute of Astronomy [Prague], Charles University [Prague] (CU), Joseph Louis LAGRANGE (LAGRANGE), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Earth, Atmospheric and Planetary Sciences [MIT, Cambridge] (EAPS), Massachusetts Institute of Technology (MIT), University of Tampere [Finland], Space Sciences, Technologies and Astrophysics Research Institute (STAR), Université de Liège, Astronomical Observatory [Poznan], Adam Mickiewicz University in Poznań (UAM), Search for Extraterrestrial Intelligence Institute (SETI), Astronomical Institute of Romanian Academy, Romanian Academy, Oukaimeden Observatory, Université Cadi Ayyad [Marrakech] (UCA), Thirty Meter Telescope Observatory, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), DOTA, ONERA, Université Paris Saclay [Palaiseau], ONERA-Université Paris-Saclay, School of Physical Sciences [Milton Keynes], Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Pontificia Universidad Católica del Perú (PUCP), Universidad de Alicante, Institut de Ciencies del Cosmos (ICCUB), Universitat de Barcelona (UB), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Agence Spatiale Européenne = European Space Agency (ESA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru (PUCP), Czech Science Foundation, Charles University (Czech Republic), Ministry of Education, Youth and Sports (Czech Republic), Centre National de la Recherche Scientifique (France), National Aeronautics and Space Administration (US), Generalitat Valenciana, Ministerio de Economía y Competitividad (España), Fonds de la Recherche Scientifique (Fédération Wallonie-Bruxelles), and Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal
Subjects: individual: (31) Euphrosyne / minor planets [Asteroids], 010504 meteorology & atmospheric sciences, general [Minor planets, asteroids], FOS: Physical sciences, Astrophysics, Asteroids: individual: (31) Euphrosyne / minor planets, 01 natural sciences, Sphericity, law.invention, Techniques: high angular resolution, Impact crater, law, Física Aplicada, 0103 physical sciences, observational [Methods], Circular orbit, 010303 astronomy & astrophysics, individual: (31) Euphrosyne [Minor planets, asteroids], ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Earth and Planetary Astrophysics (astro-ph.EP), Physics, [PHYS]Physics [physics], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Astronomy and Astrophysics, high angular resolution [Techniques], Orbit, Asteroids: general, Methods: observational / minor planets, Space and Planetary Science, Asteroid, Satellite, observational / minor planets [Methods], Hydrostatic equilibrium, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], general [Asteroids], Astrophysics - Earth and Planetary Astrophysics, Shape analysis (digital geometry)
Abstract: Aims. Asteroid (31) Euphrosyne is one of the biggest objects in the asteroid main belt and it is also the largest member of its namesake family. The Euphrosyne family occupies a highly inclined region in the outer main belt and contains a remarkably large number of members, which is interpreted as an outcome of a disruptive cratering event. Methods. The goals of this adaptive-optics imaging study are threefold: to characterize the shape of Euphrosyne, to constrain its density, and to search for the large craters that may be associated with the family formation event. Results. We obtained disk-resolved images of Euphrosyne using SPHERE/ZIMPOL at the ESO 8.2 m VLT as part of our large program (ID: 199.C-0074, PI: Vernazza). We reconstructed its 3D shape via the ADAM shape modeling algorithm based on the SPHERE images and the available light curves of this asteroid. We analyzed the dynamics of the satellite with the Genoid meta-heuristic algorithm. Finally, we studied the shape of Euphrosyne using hydrostatic equilibrium models. Conclusions. Our SPHERE observations show that Euphrosyne has a nearly spherical shape with the sphericity index of 0.9888 and its surface lacks large impact craters. Euphrosyne's diameter is 268 ± 6 km, making it one of the top ten largest main belt asteroids. We detected a satellite of Euphrosyne - S/2019 (31) 1 - that is about 4 km across, on a circular orbit. The mass determined from the orbit of the satellite together with the volume computed from the shape model imply a density of 1665 ± 242 kg m-3, suggesting that Euphrosyne probably contains a large fraction of water ice in its interior. We find that the spherical shape of Euphrosyne is a result of the reaccumulation process following the impact, as in the case of (10) Hygiea. However, our shape analysis reveals that, contrary to Hygiea, the axis ratios of Euphrosyne significantly differ from those suggested by fluid hydrostatic equilibrium following reaccumulation., This work has been supported by the Czech Science Foundation through grant 18-09470S (J. Hanuš, O. Chrenko, P. Ševecˇek) and by the Charles University Research program No. UNCE/SCI/023. M.B. was supported by the Czech Science Foundation grant 18-04514J. Computational resources were supplied by the Ministry of Education, Youth and Sports of the Czech Republic under the projects CESNET (LM2015042) and IT4Innovations National Supercomputing Centre (LM2015070). P. Vernazza, A. Drouard, M. Ferrais and B. Carry were supported by CNRS/INSU/PNP. M.M. was supported by the National Aeronautics and Space Administration under grant No. 80NSSC18K0849 issued through the Planetary Astronomy Program. The work of TSR was carried out through grant APOSTD/2019/046 by Generalitat Valen-ciana (Spain). This work was supported by the MINECO (Spanish Ministry of Economy) through grant RTI2018-095076-B-C21 (MINECO/FEDER, UE). The research leading to these results has received funding from the ARC grant for Concerted Research Actions, financed by the Wallonia-Brussels Federation. TRAPPIST is a project funded by the Belgian Fonds (National) de la Recherche Scientifique (F.R.S.-FNRS) under grant FRFC 2.5.594.09.F. TRAPPIST-North is a project funded by the Université de Liège, and performed in collaboration with Cadi Ayyad University of Marrakesh. E. Jehin is a FNRS Senior Research Associate.
Published: 2020

104. An integrated multi-omics analysis identifies clinically relevant molecular subtypes of non-muscle-invasive bladder cancer

Author: Lars Dyrskjøt, Sia Viborg Lindskrog, Mattias Höglund, Emil Christensen, Margaret A. Knowles, Xiaoqi Lin, Mateo Sokac, Gregers G. Hermann, Danijel Sikic, Francisco X. Real, Jørgen Bjerggaard Jensen, Dejan Dragicevic, Núria Malats, Joshua I. Warrick, Anshita Goel, Ulrika Segersten, Marcus Horstmann, Gottfrid Sjödahl, Veronika Weyerer, Arndt Hartmann, Ellen C. Zwarthoff, Tatjana Simic, Carolyn D. Hurst, Douglas G. Ward, Iver Nordentoft, Ann Taber, Marc-Oliver Grimm, Aurélien de Reyniès, Roman Nawroth, Kim E.M. van Kessel, Per-Uno Malmström, Philippe Lamy, Karin Birkenkamp-Demtröder, Astrid Christine Petersen, Nicolai Juul Birkbak, Frederik Prip, Trine Strandgaard, Brian J. Jordan, Richard T. Bryan, Torben Steiniche, Karin Mogensen, Tobias Maurer, David J. DeGraff, Jay D. Raman, Clarice S. Groeneveld, Lasse Maretty, and Joshua J. Meeks
Subjects: Oncology, 0303 health sciences, medicine.medical_specialty, Bladder cancer, business.industry, Disease, Proteomics, medicine.disease, Subtyping, 3. Good health, Clinical trial, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Chromosome instability, medicine, Biomarker discovery, business, 030304 developmental biology
Abstract: The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we performed a large integrative multi-omics analysis of patients diagnosed with NMIBC (n=834). Transcriptomic analysis identified four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subtyping and the level of chromosomal instability provided independent prognostic value beyond established prognostic clinicopathological parameters. High chromosomal instability, p53-pathway disruption and APOBEC-related mutations were significantly associated with transcriptomic class 2a and poor outcome. RNA-derived immune cell infiltration was associated with chromosomally unstable tumors and enriched in class 2b. Spatial proteomics analysis confirmed the higher infiltration of class 2b tumors and demonstrated an association between higher immune cell infiltration and lower recurrence rates. Finally, a single-sample classification tool was built and the independent prognostic value of the transcriptomic classes was documented in 1306 validation samples. The classifier provides a framework for novel biomarker discovery and for optimizing treatment and surveillance in next-generation clinical trials.
Published: 2020

105. Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue

Author: Richard Marais, Andrew Furness, Thomas B.K. Watkins, Maise Al-Bakir, Dionysis Papadatos-Pastos, Maryam Razaq, Mairead McKenzie, Lisa Pickering, Peter Ellery, Jonathan Ledermann, Andrew V. Biankin, Richard J. Gilbertson, Peter Cockcroft, Mary Mangwende, Sophie Ward, Mary Falzon, Cristina Naceur-Lombardelli, Carlos Caldas, Karla Pearce, Jacqui Shaw, Salma Kadiri, Lars Dyrskjøt, Mark Linch, Daniel Burgess, Nelson Alexander, Christian H. Ottensmeier, Kevin G. Blyth, Lisa L. Gallegos, Rodelaine Wilson, Hayley Bridger, Fiona H Blackhall, Peter J. Parker, Charles Swanton, Allan Hackshaw, Gert Attard, Gordon Stamp, Dean A. Fennell, Debra H. Josephs, Andrew P. Robinson, Kim Edmonds, Tina Mackay, Mita Afroza Akther, Miriam Mitchison, Sam M. Janes, Giorgia Trevisan, Adrienne M. Flanagan, Alison Cluroe, Henning Walczak, Stuart Horswell, Lena Karapagniotou, Simon Tavaré, Sarah Sarker, Teresa Marafioti, Matt Krebs, Anna Green, Philippe Lamy, Reena Khiroya, Samantha M. Hill, Andrew Tutt, Ashish Chandra, Selvaraju Veeriah, Faye Gishen, Lisa Thompson, Sarah Vaughan, Stacey Stanislaw, Kevin Litchfield, Colin Watts, Caroline Dive, Zayd Tippu, Ron Sinclair, Merche Jimenez-Linan, Lavinia Spain, Lizi Manzano, Zoe Rhodes, Caroline Stirling, Elena Provenzano, Andrew Rowan, Katey S. S. Enfield, Vasiliki Michalarea, Nahid Sheikh, Antonia Toncheva, Charlotte Ferris, James Spicer, Kai-Keen Shiu, Aida Murra, Gerald Langman, Scott Thomas Colville Shepherd, Nicholas McGranahan, Fabio Gomes, Daniel Hochhauser, Hang Xu, Sergio A. Quezada, James Larkin, Siow Ming Lee, Chi-wah Lok, Massimo Loda, Gary Middleton, Hollie Bancroft, Jo Dransfield, David Moore, Jennifer Thomas, Rebecca C. Fitzgerald, Peter Colloby, Annika Fendler, Emma Beddowes, Ultan McDermott, Christopher Abbosh, Uzma Asghar, Martin Forster, John Le Quesne, Katherine F. Leith, Paddy Stone, Bernard Olisemeke, Bruce Tanchel, Laura Farrelly, Grant D. Stewart, Justine Korteweg, Sanjay Jogai, Nnenna Kanu, Desiree Schnidrig, Heidi Rosenbaum, Elaine Borg, Mat Carter, Anthony J. Chalmers, Andrew C. Kidd, Alexandre Harlé, Ula Mahadeva, Crispin T. Hiley, Fiona Byrne, Heather Shaw, Mariam Jamal-Hanjani, Karin A. Oien, Ian Proctor, Joanne Webb, Sioban Fraser, Sarah Howlett, Ruby Stewart, Peter Van Loo, Nadia Yousaf, Tanya Ahmad, Martin Collard, Sanjay Popat, James D. Brenton, Sarah Rudman, Lewis Au, David G. Harrison, Elias Pintus, Patricia Roxburgh, Olivia Curtis, Ben Deakin, Ariana Huebner, Debra Enting, Simranpreet Summan, S. Baijal, Iver Nordentoft, Carol Jones, Haixi Yan, Sebastian Brandner, Tariq Enver, Lara-Rose Iredale, Yvonne Summers, Babu Naidu, Abby Sharp, Stephen Hazell, Aoune Barhoumi, Emma Nye, Robert E. Hynds, Sharmistha Ghosh, Emilia L. Lim, Ben Shum, Nikki Hunter, John Bridgewater, Eleanor Carlyle, Stephan Beck, Nicolai Juul Birkbak, Steve Hazell, Samra Turajlic, Amy Kerr, Ian Tomlinson, Adrian Tookman, Litchfield, Kevin [0000-0002-3725-0914], Birkbak, Nicolai J [0000-0003-1613-9587], Nordentoft, Iver [0000-0003-4856-4086], Dyrskjøt, Lars [0000-0001-7061-9851], Apollo - University of Cambridge Repository, Division of genetics and epidemiology, The institute of cancer research [London], The Wellcome Trust Centre for Human Genetics [Oxford], University of Oxford [Oxford], Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), The Royal Marsden, University of Arizona, University of Western Ontario, Physic and Astronomy Department, University of Western Ontario (UWO), Center for Biological Sequence Analysis [Lyngby], Technical University of Denmark [Lyngby] (DTU), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Aarhus University Hospital, Cancer Research UK Lung Cancer Centre of Excellence [Londres, Royaume-Uni], University College of London [London] (UCL), Comprehensive Cancer Center, UCL Cancer Institute [University College London], The Wellcome Trust Sanger Institute [Cambridge], Research Department of Pathology, Innovation North - Faculty of Information and Technology, Leeds Metropolitan University, Department of histopathology, University College Hospital, Mammalian Genetics Laboratory, Centre for Research on Adaptive Nanostructures and Nanodevices, Trinity College Dublin, Cancer Research UK London Research Institute, Guy's and St Thomas' Hospital [London], Breakthrough Breast Cancer Centre, London Institute of Cancer, Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, University of Cambridge [UK] (CAM), Cancer Division [Sydney, Australia] (The Kinghorn Cancer Centre), Garvan Institute of Medical Research [Sydney, Australia], Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, University of Manchester, University of Leicester, Experimental Cancer Medicine Centre, University of Southampton-Faculty of Medicine, Moses, Wittemyer, Harrison and Woodruff, P.C., University of Oxford, Danmarks Tekniske Universitet = Technical University of Denmark (DTU), and Garvan Institute of medical research
Subjects: 0301 basic medicine, tumor sequencing, medicine.medical_specialty, Sampling protocol, tumor mutational burden, tumor sampling, Lung Neoplasms, molecular profiling, Biopsy, homogenization, Tissue sample, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, medicine, Biomarkers, Tumor, Humans, Solid tumor, lcsh:QH301-705.5, Representative sampling, medicine.diagnostic_test, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Clonal structure, biomarkers, High-Throughput Nucleotide Sequencing, Tumor tissue, tumor hetereogeneity, Tumor Burden, 030104 developmental biology, lcsh:Biology (General), representative sampling, Urinary Bladder Neoplasms, Mutation, Radiology, 030217 neurology & neurosurgery
Abstract: International audience; Although thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias isinherent in current methodologies. This is caused by a tissue sample input of fixed dimensions (e.g., 6 mmbiopsy), which becomes grossly under-powered as tumor volume scales. Here, we demonstrate representative sequencing (Rep-Seq) as a new method to achieve unbiased tumor tissue sampling. Rep-Seq uses fixed residual tumor material, which is homogenized and subjected to next-generation sequencing. Analysis of intratumor tumor mutation burden (TMB) variability shows a high level of misclassification using current single-biopsy methods, with 20% of lung and 52% of bladder tumors having at least one biopsy with high TMB butlow clonal TMB overall. Misclassification rates by contrast are reduced to 2% (lung) and 4% (bladder) when a more representative sampling methodology is used. Rep-Seq offers an improved sampling protocol for tumor profiling, with significant potential for improved clinical utility and more accurate deconvolution of clonal structure.
Published: 2020

106. Improving social function with real-world social-cognitive remediation in schizophrenia: Results from the RemedRugby quasi-experimental trial

Author: Isabelle Chereau, Fanny Melis, Pierre-Michel Llorca, Motassem Bakri, Thierry Lucas, Yohan Souchet, Emmanuelle Pages, Sophie Morel, F. Gabayet, Celine Roussel, Catherine Massoubre, Romain Rey, Julien Dubreucq, Mégane Faraldo, Titaua Challe, Bernard Ycart, B. Arnaud, Florian Carmona, G Legrand, Sylvie Pires, Philippe Lamy, Gentiane Cambier, Romain Pommier, Mickael Bacconnier, Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (CNC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Centre Référent de Réhabilitation Psychosociale [CH Alpes Isère], Centre Hospitalier Alpes Isère, Fondation FondaMental [Créteil], Réseau Handicap Psychique RéHPSY, Statistique pour le Vivant et l’Homme (SVH), Laboratoire Jean Kuntzmann (LJK), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), CHU Clermont-Ferrand, Etablissement médical de La Teppe, Centre de Réhabilitation Psychosociale et de Remédiation Cognitive, CH Drome Vivarais, Centre Hospitalier Spécialisé de la Savoie, REHALise, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre Départemental de Réhabilitation Psychosociale des Glières, Centre Hospitalier le Vinatier [Bron], Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 (ISC-MJ), and Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)
Subjects: Adult, Male, Physical fitness, Psychological intervention, social cognitive remediation, Social Skills, 03 medical and health sciences, 0302 clinical medicine, touchrugby, Medicine, Humans, Social Behavior, Positive and Negative Syndrome Scale, business.industry, Aggression, Physical activity, Cognition, medicine.disease, Combined Modality Therapy, Cognitive Remediation, 030227 psychiatry, 3. Good health, Exercise Therapy, schizophrenia, Psychiatry and Mental health, Schizophrenia, social function, Female, medicine.symptom, business, Psychosocial, 030217 neurology & neurosurgery, Social cognitive theory, [MATH.MATH-NA]Mathematics [math]/Numerical Analysis [math.NA], Clinical psychology, Follow-Up Studies, Research Article
Abstract: Background.Functional capacity (FC) has been identified as a key outcome to improve real-world functioning in schizophrenia. FC is influenced by cognitive impairments, negative symptoms, self-stigma and reduced physical activity (PA). Psychosocial interventions targeting FC are still under-developed.Methods.we conducted a quasi-experimental study evaluating the effects of an exercise-enriched integrated social cognitive remediation (SCR) intervention (RemedRugby [RR]) compared with an active control group practicing Touch Rugby (TR). To our knowledge, this is the first trial to date evaluating the effectiveness of such a program provided in a real-life environment.Results.Eighty-seven people with schizophrenia were included and allocated to either the RR group (n= 57) or the TR group (n= 30) according to the routine clinical practice of the recruiting center. Outcomes were evaluated at baseline and post-treatment in both groups and after 6 months of follow-up in the RR group using standardized scales for symptom severity, social functioning, self-stigma, and a large cognitive battery. After treatment we observed moderate to large improvements in social function (Personal and Social Performance Scale [PSP],p< 0.001,d= 1.255), symptom severity (Positive and Negative Syndrome Scale [PANSS] negative,p< 0.001,d= 0.827; PANSS GP,p< 0.001,d= 0.991; PANSS positive,p= 0.009,d= 0.594), verbal abstraction (p= 0.008,d= 0.554), aggression bias (p= 0.008,d= 0.627), and self-stigma (stereotype endorsement,p= 0.019,d= 0.495; discrimination experiences,p= 0.047;d= 0.389) that were specific to the RR group and were not observed in participants playing only TR. Effects were persistent over time and even larger between post-treatment and follow-up.Conclusions.Exercise-enriched integrated SCR appears promising to improve real-life functioning in schizophrenia. Future research should investigate the potential effects of this intervention on neuroplasticity and physical fitness.
Published: 2020

107. The violent collisional history of aqueously evolved (2) Pallas

Author: Alexis Drouard, Franck Marchis, Romain Fétick, Arthur Vigan, Miroslav Brož, Julie Castillo-Rogez, Herve Le Coroller, Christophe Dumas, Josef Hanus, Toni Santana-Ros, Paolo Tanga, Patrick Michel, Matti Viikinkoski, Mirel Birlan, E. Podlewska-Gaca, Fabrice Cipriani, Bin Yang, Nicolas Rambaux, Mikko Kaasalainen, Thierry Fusco, Grzegorz Dudziński, Tadeusz Michalowski, Benoit Carry, Agnieszka Kryszczyńska, Przemyslaw Bartczak, P. Ševeček, Jérôme Berthier, Laurent Jorda, Josef Ďurech, Michael Marsset, François Colas, Derek C. Richardson, Marin Ferrais, A. Marciniak, Frédéric Vachier, Erik Asphaug, Pierre Vernazza, Emmanuel Jehin, Olivier Witasse, Philippe Lamy, European Commission, National Aeronautics and Space Administration (US), Generalitat Valenciana, Astrophysics Research Centre [Belfast] (ARC), Queen's University [Belfast] (QUB), Astronomical Institute of Charles University, Charles University [Prague] (CU), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Department of Mathematics [Tampere], Tampere University of Technology [Tampere] (TUT), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Search for Extraterrestrial Intelligence Institute (SETI), Astronomical Observatory [Poznan], Adam Mickiewicz University in Poznań (UAM), Lunar and Planetary Laboratory [Tucson] (LPL), University of Arizona, European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Faculty of Mathematics and Physics [Praha/Prague], Université de Liège, Les Afriques dans le monde (LAM), Sciences Po Bordeaux - Institut d'études politiques de Bordeaux (IEP Bordeaux)-Institut de Recherche pour le Développement (IRD)-Institut d'Études Politiques [IEP] - Bordeaux-Université Bordeaux Montaigne-Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay [Châtillon], ONERA-Université Paris-Saclay, Space Sciences, Technologies and Astrophysics Research Institute (STAR), Observatoire de Haute-Provence (OHP), Institut Pythéas (OSU PYTHEAS), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Amgen (Europe) GmbH, De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics (LESIA), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Agence Spatiale Européenne = European Space Agency (ESA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Sciences Po Bordeaux - Institut d'études politiques de Bordeaux (IEP Bordeaux)-Institut de Recherche pour le Développement (IRD)-Institut d'Études Politiques [IEP] - Bordeaux-Université Bordeaux Montaigne (UBM)-Centre National de la Recherche Scientifique (CNRS), and Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal
Subjects: Very Large Telescope, 010504 meteorology & atmospheric sciences, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Asteroid (2) Pallas, Violent collisional history, Astronomy and Astrophysics, Orbital eccentricity, Astrophysics, Aqueous alteration, Albedo, 01 natural sciences, Orbital inclination, Bright spot, Impact crater, 13. Climate action, Chondrite, Asteroid, Física Aplicada, 0103 physical sciences, 010303 astronomy & astrophysics, Geology, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: et al., Asteroid (2) Pallas is the largest main-belt object not yet visited by a spacecraft, making its surface geology largely unknown and limiting our understanding of its origin and collisional evolution. Previous ground-based observational campaigns returned different estimates of its bulk density that are inconsistent with one another, one measurement1 being compatible within error bars with the icy Ceres (2.16 ± 0.01 g cm−3)2 and the other3 compatible within error bars with the rocky Vesta (3.46 ± 0.03 g cm−3)4. Here we report high-angular-resolution observations of Pallas performed with the extreme adaptive optics-fed SPHERE imager5 on the Very Large Telescope. Pallas records a violent collisional history, with numerous craters larger than 30 km in diameter populating its surface and two large impact basins that could be related to a family-forming impact. Monte Carlo simulations of the collisional evolution of the main belt correlate this cratering record to the high average impact velocity of ~11.5 km s−1 on Pallas—compared with an average of ~5.8 km s−1 for the asteroid belt—induced by Pallas’s high orbital inclination (i = 34.8°) and orbital eccentricity (e = 0.23). Compositionally, Pallas’s derived bulk density of 2.89 ± 0.08 g cm−3 (1σ uncertainty) is fully compatible with a CM chondrite-like body, as suggested by its spectral reflectance in the 3 μm wavelength region6. A bright spot observed on its surface may indicate an enrichment in salts during an early phase of aqueous alteration, compatible with Pallas’s relatively high albedo of 12–17% (refs. 7,8), although alternative origins are conceivable., Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere under ESO programme 199.C-0074 (principal investigator: P.V.). This research has made use of the Keck Observatory Archive (KOA), which is operated by the W. M. Keck Observatory and the NASA Exoplanet Science Institute (NExScI), under contract with NASA. M.M. was supported by the National Aeronautics and Space Administration under grant number 80NSSC18K0849 issued through the Planetary Astronomy Program. This work was supported by the French Direction Générale de l’Armement (DGA) and Aix-Marseille Université (AMU). P.V., A.D. and B.C. were supported by CNRS/INSU/PNP. J.H., J.D. and P.S. were supported by the grant 18-09470S of the Czech Science Foundation and by the Charles University Research Programme number UNCE/SCI/023. M.Brož was supported by the grant 18-04514J of the Czech Science Foundation. E.J. is a F.R.S.-FNRS Senior Research Associate. The work of T.S.-R. was carried out through grant APOSTD/2019/046 by Generalitat Valenciana (Spain). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement number 730890.
Published: 2020

108. Coronal Photopolarimetry with the LASCO-C2 Coronagraph over 24 Years [1996-2019] -- Application to the K/F Separation and to the Determination of the Electron Density

Author: Hugo Gilardy, A. Llebaria, Brice Boclet, Olivier Floyd, Michael Burtin, and Philippe Lamy
Subjects: Physics, 010504 meteorology & atmospheric sciences, Stray light, Polarimetry, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Polarizer, Polarization (waves), 01 natural sciences, Corona, law.invention, Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, law, 0103 physical sciences, Physics::Space Physics, Astrophysics::Solar and Stellar Astrophysics, Mueller calculus, 010303 astronomy & astrophysics, Coronagraph, Solar and Stellar Astrophysics (astro-ph.SR), 0105 earth and related environmental sciences, Eclipse
Abstract: We present an in-depth characterization of the polarimetric channel of the Large-Angle Spectrometric COronagraph LASCO-C2 onboard the Solar and Heliospheric Observatory (SoHO). The polarimetric analysis of the white-light images makes use of polarized sequences composed of three images obtained though three polarizers oriented at +60{\deg}, 0{\deg} and -60{\deg}, complemented by a neighboring unpolarized image, and relies on the formalism of Mueller. The Mueller matrix characterizing the C2 instrument was obtained through extensive ground-based calibrations of the optical components and global laboratory tests. Additional critical corrections were derived from in-flight tests relying prominently on roll sequences and on consistency criteria, mainly the tangential direction of polarization. Our final results encompass the characterization of the polarization of the white-light corona, of its polarized radiance, of the two-dimensional electron density, and of the K-corona over two solar cycles. They are in excellent agreement with measurements obtained at several solar eclipses except for slight discrepancies affecting the innermost part of the C2 field-of-view, probably resulting from an imperfect removal of the bright diffraction fringe surrounding the occulter., Comment: 72 pages, 51 figures
Published: 2020
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109. Validation of the Alfvén Wave Solar Atmosphere Model (AWSoM) with Observations from the Low Corona to 1 au

Author: Alberto M. Vásquez, Bart van der Holst, Gabor Toth, Hsiu-Shan Yu, Bernard V. Jackson, Nishtha Sachdeva, Julien Wojak, D. G. Lloveras, Ward B. Manchester, Carl J. Henney, Yuxi Chen, Philippe Lamy, Department of Climate and Space Sciences and Engineering (CLaSP), University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Instituto de Astronomía y Física del Espacio [Buenos Aires] (IAFE), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad de Buenos Aires [Buenos Aires] (UBA), Departamento de Ciencia y Tecnología [Buenos Aires], Universidad Nacional de Quilmes (UNQ), HELIOS - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Center for Astrophysics and Space Sciences [La Jolla] (CASS), University of California [San Diego] (UC San Diego), University of California-University of California, AFRL Space Vehicles Directorate, Air Force Research Laboratory (AFRL), United States Air Force (USAF)-United States Air Force (USAF), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and University of California (UC)-University of California (UC)
Subjects: Physics, 010504 meteorology & atmospheric sciences, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Interplanetary medium, Astronomy and Astrophysics, Solar atmosphere, 01 natural sciences, Corona, Computational physics, Alfvén wave, Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics, 13. Climate action, Space and Planetary Science, Physics::Space Physics, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, Magnetohydrodynamics, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: We perform a validation study of the latest version of the Alfv\'{e}n Wave Solar atmosphere Model (AWSoM) within the Space Weather Modeling Framework (SWMF). To do so, we compare the simulation results of the model with a comprehensive suite of observations for Carrington rotations representative of the solar minimum conditions extending from the solar corona to the heliosphere up to the Earth. In the low corona ($r < 1.25$ \Rs), we compare with EUV images from both STEREO-A/EUVI and SDO/AIA and to three-dimensional (3-D) tomographic reconstructions of the electron temperature and density based on these same data. We also compare the model to tomographic reconstructions of the electron density from SOHO/LASCO observations ($2.55 < r < 6.0$\Rs). In the heliosphere, we compare model predictions of solar wind speed with velocity reconstructions from InterPlanetary Scintillation (IPS) observations. For comparison with observations near the Earth, we use OMNI data. Our results show that the improved AWSoM model performs well in quantitative agreement with the observations between the inner corona and 1 AU. The model now reproduces the fast solar wind speed in the polar regions. Near the Earth, our model shows good agreement with observations of solar wind velocity, proton temperature and density. AWSoM offers an extensive application to study the solar corona and larger heliosphere in concert with current and future solar missions as well as being well suited for space weather predictions.
Published: 2019

110. Polarimetric Reconstruction of Coronal Mass Ejections from LASCO-C2 Observations

Author: Olivier Floyd, Philippe Lamy, HELIOS - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), and Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)
Subjects: Solar System, 010504 meteorology & atmospheric sciences, Thomson scattering, media_common.quotation_subject, Polarimetry, Astrophysics, 01 natural sciences, law.invention, law, 0103 physical sciences, Coronal mass ejection, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, Coronagraph, 0105 earth and related environmental sciences, media_common, Physics, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Astronomy and Astrophysics, Polarization (waves), Corona, Space and Planetary Science, Sky, Physics::Space Physics, Coronal Mass Ejections
Abstract: International audience; The three-dimensional morphology and direction of propagation of coronal mass ejections (CMEs) are essential information for identifying their source on the solar disk, for understanding the processes of their ejection and propagation in the corona, and for forecasting their possible impact with the Earth or any other objects in the solar system. The polarization of the Thomson scattering by an electron is known to provide information on its position with respect to the plane of the sky. This polarimetric technique is applied to reconstruct 15 CMEs on the basis of white-light polarized images obtained with the Large Angle Spectrometric Coronagraph (LASCO) C2, which have been extensively corrected for instrumental effects. It does provide valuable results in spite of the time delays between the three observations required to build the polarization maps. Most of these CMEs exhibit complex structures making a classification in terms of simple shapes such as arcade of loops or flux rope difficult or even questionable. Three of these CMEs benefited from multiple observations allowing us to follow their three-dimensional development as they propagated outward. All CMEs are tracked back to the solar surface and in several instances, active regions are identified as the probable sources. Finally, the projected speeds and masses derived from white-light unpolarized observations have been corrected for the projection angle to produce unbiased values.
Published: 2019

111. Metis: the Solar Orbiter visible light and ultraviolet coronal imager

Author: Ernesto Massa, Udo Schühle, Stefano Pieraccini, Pilar García Parejo, Stefano Cesare, Sami K. Solanki, Roberto Boccardo, Vito Centonze, Danilo Morea, Gianalfredo Nicolini, Maurizio Pancrazzi, Federico Landini, Daniele Quattropani, A. Berlicki, Hardi Peter, Felice Del Forno, Luca Poletto, Joachim Woch, Barbara Negri, Thimo Meierdierks, Vania Da Deppo, Ester Antonucci, A. M. Malvezzi, Rita Ventura, Tiziano Schillaci, María Cebollero, Enrico Magli, Luca Teriaca, Arianna Pandi, Giampiero Naletto, Mauro Montabone, Silvano Fineschi, Rita Carpentiero, Jean-Claude Vial, J. Daniel Moses, Mauro Messerotti, German Fernandez Rico, R. Enge, Paolo Sarra, Marco Castronuovo, Paola Zuppella, Sébastien Vivès, K. Heerlein, Giancarlo Noci, Alberto Álvarez-Herrero, F. Marliani, R. Bertacin, Silvia Natalucci, Cristian Baietto, Gerardo Capobianco, Giuseppe Crescenzio, Thomas Straus, Marta Casti, Maria G. Pelizzo, Fabio Frassetto, Jan Staub, Lucia Abbo, Clementina Sasso, Giuseppe Massone, Marco Velli, Paolo Radaelli, Philippe Lamy, Alessio Gravina, Marco Ricci, Frédéric Auchère, Alessandro Gabrielli, Rosario Brando, Marco Romoli, Petr Heinzel, Vincenzo Andretta, Philippe Laget, Radek Melich, Antonio Volpicelli, Regina Aznar Cuadrado, Piergiorgio Nicolosi, Giuseppe Tondello, Kanaris Tsinganos, Catia Grimani, Daniele Telloni, Alessandro Bemporad, Riccardo Bertone, Roberto Bruno, Alain Jody Corso, Michela Uslenghi, Mauro Focardi, Enrico Verroi, Andreas Zerr, M.G. Sertsu, Sergio Mottini, D. Spadaro, Stephan Werner, Marco Cesa, Paolo Sandri, Mauro Amoruso, Miguel Alvarez Copano, A. C. Lanzafame, Ioanna Papagiannaki, Raffaella D'Amicis, Sonja Jejčič, Roberto Susino, Angela Ciaravella, S. Dolei, Leonard Strachan, Laboratoire d'Astrophysique de Marseille (LAM), and Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Sun. corona, Sun: atmosphere, Sun: corona, Sun: UV radiation, FOS: Physical sciences, Astrophysics, 01 natural sciences, Sun: atmosphere – Sun: corona – Sun: UV radiation, law.invention, 010309 optics, Orbiter, Sun. atmosphere, Sun. UV radiation, law, 0103 physical sciences, Coronal mass ejection, Astrophysics::Solar and Stellar Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Coronagraph, Solar and Stellar Astrophysics (astro-ph.SR), Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Solar energetic particles, Astronomy, Astronomy and Astrophysics, Solar physics, Corona, Solar wind, Astrophysics - Solar and Stellar Astrophysics, [SDU]Sciences of the Universe [physics], Space and Planetary Science, Physics::Space Physics, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Heliosphere
Abstract: Aims. Metis is the first solar coronagraph designed for a space mission and is capable of performing simultaneous imaging of the off-limb solar corona in both visible and UV light. The observations obtained with Metis aboard the Solar Orbiter ESA-NASA observatory will enable us to diagnose, with unprecedented temporal coverage and spatial resolution, the structures and dynamics of the full corona in a square field of view (FoV) of ±2.9° in width, with an inner circular FoV at 1.6°, thus spanning the solar atmosphere from 1.7R⊙to about 9R⊙, owing to the eccentricity of the spacecraft orbit. Due to the uniqueness of the Solar Orbiter mission profile, Metis will be able to observe the solar corona from a close (0.28 AU, at the closest perihelion) vantage point, achieving increasing out-of-ecliptic views with the increase of the orbit inclination over time. Moreover, observations near perihelion, during the phase of lower rotational velocity of the solar surface relative to the spacecraft, allow longer-term studies of the off-limb coronal features, thus finally disentangling their intrinsic evolution from effects due to solar rotation.Methods. Thanks to a novel occultation design and a combination of a UV interference coating of the mirrors and a spectral bandpass filter, Metis images the solar corona simultaneously in the visible light band, between 580 and 640 nm, and in the UV H ILyman-αline at 121.6 nm. The visible light channel also includes a broadband polarimeter able to observe the linearly polarised component of the K corona. The coronal images in both the UV H ILyman-αand polarised visible light are obtained at high spatial resolution with a spatial scale down to about 2000 km and 15 000 km at perihelion, in the cases of the visible and UV light, respectively. A temporal resolution down to 1 s can be achieved when observing coronal fluctuations in visible light.Results. The Metis measurements, obtained from different latitudes, will allow for complete characterisation of the main physical parameters and dynamics of the electron and neutral hydrogen/proton plasma components of the corona in the region where the solar wind undergoes the acceleration process and where the onset and initial propagation of coronal mass ejections (CMEs) take place. The near-Sun multi-wavelength coronal imaging performed with Metis, combined with the unique opportunities offered by the Solar Orbiter mission, can effectively address crucial issues of solar physics such as: the origin and heating/acceleration of the fast and slow solar wind streams; the origin, acceleration, and transport of the solar energetic particles; and the transient ejection of coronal mass and its evolution in the inner heliosphere, thus significantly improving our understanding of the region connecting the Sun to the heliosphere and of the processes generating and driving the solar wind and coronal mass ejections.Conclusions. This paper presents the scientific objectives and requirements, the overall optical design of the Metis instrument, the thermo-mechanical design, and the processing and power unit; reports on the results of the campaigns dedicated to integration, alignment, and tests, and to the characterisation of the instrument performance; describes the operation concept, data handling, and software tools; and, finally, the diagnostic techniques to be applied to the data, as well as a brief description of the expected scientific products. The performance of the instrument measured during calibrations ensures that the scientific objectives of Metis can be pursued with success.
Published: 2019

112. Spectrophotometric variegation of the layering in comet 67P/Churyumov-Gerasimenko as seen by OSIRIS

Author: Cesare Barbieri, W-H. Ip, Pedro J. Gutiérrez, Jakob Deller, Björn Davidsson, D. Bodewits, Gloria Tognon, R. Rodrigo, F. La Forgia, V. Petropoulou, Philippe Lamy, Prasanna Deshapriya, H. U. Keller, Cecilia Tubiana, M. A. Barucci, Holger Sierks, V. Da Deppo, Carsten Güttler, Matteo Massironi, Marco Fulle, Imre Toth, Michel Franceschi, Sabrina Ferrari, Giampiero Naletto, Alice Lucchetti, Detlef Koschny, M. De Cecco, E. Frattin, Sonia Fornasier, J. J. Lopez-Moreno, Monica Lazzarin, Maurizio Pajola, Ivano Bertini, Luca Penasa, Luisa Lara, Francesca Ferri, Francesco Marzari, Pamela Cambianica, Jean-Loup Bertaux, Gabriele Cremonese, Stefano Debei, Xian Shi, Stefano Mottola, Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Universita degli Studi di Padova, Dipartimento di Fisica e Astronomia 'Galileo Galilei', Dipartimento di Geoscienze [Padova], CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), International Space Science Institute [Bern] (ISSI), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Department of Physics [Auburn], Auburn University (AU), CNR Institute for Photonics and Nanotechnologies (IFN), Department of Industrial Engineering [Padova], University of Trento [Trento], INAF - Osservatorio Astronomico di Trieste (OAT), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Università degli Studi di Padova = University of Padua (Unipd), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), NASA-California Institute of Technology (CALTECH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Agence Spatiale Européenne = European Space Agency (ESA), German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), IMPEC - LATMOS, Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Technische Universität Braunschweig [Braunschweig], Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Tognon, Gloria, Ferrari, S., Penasa, L., La Forgia, F., Massironi, M., Naletto, G., Lazzarin, M., Cambianica, P., Lucchetti, A., Pajola, M., Ferri, F., Güttler, C., Davidsson, B., Deshapriya, P., Fornasier, S., Mottola, S., Tóth, I., Sierks, H., Lamy, P. L., Rodrigo, R., Koschny, D., Barbieri, C., Barucci, M. A., Bertaux, J. -L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, V., Debei, S., De Cecco, M., Deller, J., Franceschi, M., Frattin, E., Fulle, M., Gutiérrez, P. J., Ip, W. -H., Keller, H. U., Lara, L. M., López-Moreno, J. J., Marzari, F., Petropoulou, V., Shi, X., and Tubiana, C.
Subjects: Brightness, 010504 meteorology & atmospheric sciences, Outcrop, Multispectral image, Narrow angle, Astrophysics, 01 natural sciences, WATER ICE, NUCLEUS, individual: 67P/Churyumov-Gerasimenko [Comets], Methods: data analysis, 0103 physical sciences, data analysis [methods], medicine, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Comets: individual: 67P/Churyumov-Gerasimenko, Physics, Multispectral data, biology, general [Comets], Astronomy and Astrophysics, biology.organism_classification, Lobe, Comets: general, medicine.anatomical_structure, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], comets: general – comets: individual: 67P/Churyumov-Gerasimenko – methods: data analysis, Osiris, Layering, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Between August 2014 and September 2016, the ESA space mission Rosetta escorted comet 67P/Churyumov-Gerasimenko (67P) during its perihelion passage. The onboard OSIRIS Narrow Angle Camera (NAC) acquired high-resolution multispectral images of the cometary surface. These datasets allowed a characterization of the spectrophotometric variegation of the layering of the large lobe, correlated with the layer structural elevation. Aims. We perform a spectrophotometric characterization of the outcropping stratification of the small lobe of 67P as a function of its structural elevation, and consequently, a spectrophotometric comparison of the layered outcrops of the two lobes. Methods. We selected two sequences of post-perihelion OSIRIS NAC images (similar to 2.4 au outbound to the Sun), from which we built up two multispectral images, framing an extended geological section of the onion-like stratification of the small lobe. Then we classified the consolidated areas of the outcropping and the relative coarse deposits that were identified in the multispectral data with a two-class maximum likelihood method. For this, we defined the classes as a function of the structural elevation of the surface. Results. As a result, we identified a brightness variegation of the surface reflectance that is correlated with the structural elevation. The outer class, which is located at higher elevations, appears darker than the inner class. This fits previously obtained results for the large lobe. The reflectance values of the nucleus of 67P tend to decrease with increasing structural elevation. Conclusions. The observed spectrophotometric variegation can be due to a different texture as well as to a different content of volatiles and refractories. We suggest that the outer outcrops appear darker because they have been exposed longer, and the inner outcrops appear brighter because the surface has been more effectively rejuvenated. We interpret this variegation as the result of an evolutionary process.© ESO 2019, We are grateful to Andrea Longobardo for suggestions and corrections that improved our paper. OSIRIS was built by a consortium of the Max-Planck-Institut fur Sonnensystemforschung, Gottingen, Germany, CISAS - University of Padova, Italy, the Laboratoire d'Astrophysique de Marseille, France, the Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, the Research and Scientific Support Department of the European Space Agency, Noordwijk, The Netherlands, the Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, the Universidad Politechnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut fur Datentechnik und Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged.
Published: 2019

113. Validation of MHD Model Predictions of the Corona with LASCO-C2 Polarized Brightness Images

Author: Pete Riley, Philippe Lamy, Zoran Mikic, Olivier Floyd, HELIOS - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), and Predictive Science, Inc.
Subjects: Physics, Electron density, Brightness, Solar observatory, 010504 meteorology & atmospheric sciences, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Astronomy and Astrophysics, Astrophysics, 01 natural sciences, Corona, law.invention, Photometry (optics), Space and Planetary Science, law, 0103 physical sciences, Radiance, Magnetohydrodynamics, 010303 astronomy & astrophysics, Coronagraph, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract: Progress in our understanding of the solar corona requires that the results of advanced magnetohydrodynamic models driven by measured magnetic fields, and particularly the underlying heating models, be thoroughly compared with coronal observations. The comparison has so far mainly concerned the global morphology of the corona, synthetic images calculated from the models being compared with observed images. We go one step further by performing detailed quantitative comparisons between the calculated polarized radiance $pB$ using the three-dimensional electron density produced by MHD models and well calibrated polarized images obtained by the Large Angle Spectrometric Coronagraph LASCO-C2 coronagraph complemented by ground-based images when available from the Mauna Loa Solar Observatory Mark IV and K-Cor instruments to extend the comparison to the inner coronal region 1.0 – 2.5 $\mbox{R}_{\odot }$, which is inaccessible to C2. We take advantage of the high-resolution and high-quality MHD predictions performed for several solar eclipses (1 August 2008, 11 July 2010, 13 November 2012, and 21 August 2017) and for the first perihelion passage of the Parker Solar Probe (5 November 2018) using two different three-dimensional MHD models relying on either a thermodynamic or a wave-turbulence-driven methodologies to heat the corona. Both models are generally able to match the observed structure and photometry of the corona albeit with various degrees of fidelity for which there is no obvious explanation. However, two limitations emerge, the complexity of coronae of the maximum type and the time lapse between the completion of the magnetograph measurements and the prediction.
Published: 2019

114. Monitoring Treatment Response and Metastatic Relapse in Advanced Bladder Cancer by Liquid Biopsy Analysis

Author: Michael Knudsen, Emil Christensen, Jørgen Bjerggaard Jensen, Søren Høyer, Lars Dyrskjøt, Philippe Lamy, Iver Nordentoft, Mads Agerbæk, Ann Taber, and Karin Birkenkamp-Demtröder
Subjects: Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Class I Phosphatidylinositol 3-Kinases, Urology, medicine.medical_treatment, Urinary Bladder, Antineoplastic Agents, Disease, Cystectomy, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Internal medicine, Biomarkers, Tumor, Humans, Receptor, Fibroblast Growth Factor, Type 3, Medicine, Neoplasm Invasiveness, Neoplasm Metastasis, Liquid biopsy, Exome, Polymerase chain reaction, Neoplasm Staging, Bladder cancer, business.industry, Liquid Biopsy, DNA, Neoplasm, Middle Aged, medicine.disease, Neoadjuvant Therapy, Surgery, Treatment Outcome, 030104 developmental biology, Urinary Bladder Neoplasms, Cell-free fetal DNA, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, Neoplasm Recurrence, Local, business
Abstract: Of the patients undergoing radical cystectomy, 20-80% experience relapse. Minimally invasive methods for early detection of metastatic relapse after cystectomy and for monitoring ongoing therapy are urgently needed to improve individualised follow-up and treatment. Therefore, we evaluated the use of circulating tumour DNA (ctDNA) in plasma and urine to detect metastatic relapse after cystectomy and measure treatment efficacy. We exome sequenced tumour and germline DNA from patients with muscle-invasive bladder cancer and monitored ctDNA in 370 liquid biopsies throughout the disease courses by 84 personalised digital droplet polymerase chain reaction assays targeting 61 genes. Patients were prospectively recruited between 2013 and 2017. Patients with metastatic relapse had significantly higher ctDNA levels compared with disease-free patients (p
Published: 2018

115. A Hidden Markov Model to estimate population mixture and allelic copy-numbers in cancers using Affymetrix SNP arrays.

Author: Philippe Lamy, Claus L. Andersen, Lars Dyrskjot, Niels Torring, and Carsten Wiuf
Published: 2007
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116. Spatio-temporal analysis and forward modeling of solar polar plumes in white light.

Author: Antoine Llebaria, O. Morillot, Yannick Boursier, and Philippe Lamy
Published: 2011
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117. Restitution of multiple overlaid components on extremely long series of solar corona images.

Author: Antoine Llebaria, J. Loirat, and Philippe Lamy
Published: 2010
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118. OASIS: a simulator to prepare and interpret remote imaging of solar system bodies.

Author: Laurent Jorda, S. Spjuth, H. Uwe Keller, Philippe Lamy, and Antoine Llebaria
Published: 2010
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119. Rseg - an R package to optimize segmentation of SNP array data.

Author: Philippe Lamy, Carsten Wiuf, Torben F. ørntoft, and Claus L. Andersen
Published: 2011
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120. Separation of limb and terminator on apparent contours of solar system small bodies.

Author: Antoine Llebaria, Laurent Jorda, O. Groussin, Gilles Gesquière, and Philippe Lamy
Published: 2009
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121. Clinical Implications of Monitoring Circulating Tumor DNA in Patients with Colorectal Cancer

Author: Hans Jørgen Nielsen, Thomas Reinert, Katrine Stribolt, Ditte Andreasen, Lone V. Schøler, Michael Knudsen, Mai-Britt Worm Ørntoft, Torben F. Ørntoft, Philippe Lamy, Iver Nordentoft, Frank Viborg Mortensen, Peter Mouritzen, Anders Riegels Knudsen, Sigrid S. Árnadóttir, Søren Laurberg, Kim Sivesgaard, Christine Gaasdal Kassentoft, Søren Vang, and Claus L. Andersen
Subjects: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Neoplasm, Residual, Colorectal cancer, Memory, Episodic, Disease, Circulating Tumor DNA, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Recurrence, Internal medicine, Biomarkers, Tumor, Journal Article, medicine, Humans, Prospective Studies, Neoplasm Metastasis, Prospective cohort study, Neoplasm Staging, business.industry, Liquid Biopsy, Cancer, Prognosis, medicine.disease, Minimal residual disease, Confidence interval, Surgery, 030104 developmental biology, 030220 oncology & carcinogenesis, Localized disease, Colorectal Neoplasms, Tomography, X-Ray Computed, business
Abstract: Purpose: We investigated whether detection of ctDNA after resection of colorectal cancer identifies the patients with the highest risk of relapse and, furthermore, whether longitudinal ctDNA analysis allows early detection of relapse and informs about response to intervention. Experimental Design: In this longitudinal cohort study, we used massively parallel sequencing to identify somatic mutations and used these as ctDNA markers to detect minimal residual disease and to monitor changes in tumor burden during a 3-year follow-up period. Results: A total of 45 patients and 371 plasma samples were included. Longitudinal samples from 27 patients revealed ctDNA postoperatively in all relapsing patients (n = 14), but not in any of the nonrelapsing patients. ctDNA detected relapse with an average lead time of 9.4 months compared with CT imaging. Of 21 patients treated for localized disease, six had ctDNA detected within 3 months after surgery. All six later relapsed compared with four of the remaining patients [HR, 37.7; 95% confidence interval (CI), 4.2–335.5; P < 0.001]. The ability of a 3-month ctDNA analysis to predict relapse was confirmed in 23 liver metastasis patients (HR 4.9; 95% CI, 1.5–15.7; P = 0.007). Changes in ctDNA levels induced by relapse intervention (n = 19) showed good agreement with changes in tumor volume (κ = 0.41; Spearman ρ = 0.4). Conclusions: Postoperative ctDNA detection provides evidence of residual disease and identifies patients at very high risk of relapse. Longitudinal surveillance enables early detection of relapse and informs about response to intervention. These observations have implications for the postoperative management of colorectal cancer patients. Clin Cancer Res; 23(18); 5437–45. ©2017 AACR.
Published: 2017

122. Long-term monitoring of comet 67P/Churyumov–Gerasimenko’s jets with OSIRIS onboard Rosetta

Author: Holger Sierks, Ekkehard Kührt, Philippe Lamy, L. M. Lara, Marco Fulle, M. De Cecco, Monica Lazzarin, H. U. Keller, A. Gicquel, M. I. Schmitt, Dennis Bodewits, Xian Shi, Jessica Agarwal, J. J. López-Moreno, Imre Toth, M. F. A'Hearn, Stefano Mottola, Olivier Groussin, Sonia Fornasier, R. Rodrigo, J. L. Bertaux, Frank Scholten, Cesare Barbieri, D. Prasanna, Jörg Knollenberg, Stefano Debei, Jakob Deller, Wing-Huen Ip, Stubbe F. Hviid, Carsten Güttler, Björn Davidsson, Cecilia Tubiana, Laurent Jorda, Nilda Oklay, Ivano Bertini, Michael Küppers, Detlef Koschny, Nicolas Thomas, G. Cremonese, Francesco Marzari, J.-B. Vincent, V. Da Deppo, Mohamed Ramy El-Maarry, Marc Hofmann, Maurizio Pajola, Hans Rickman, J.-R. Kramm, P. J. Gutierrez, M. A. Barucci, Giampiero Naletto, Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Dipartimento di Fisica e Astronomia 'Galileo Galilei', Università degli Studi di Padova = University of Padua (Unipd), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), Department of Physics and Astronomy [Uppsala], Uppsala University, Space Research Centre of Polish Academy of Sciences (CBK), Polska Akademia Nauk = Polish Academy of Sciences (PAN), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), CNR Institute for Photonics and Nanotechnologies (IFN), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Department of Industrial Engineering [Padova], University of Trento [Trento], INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Institute of Space Science [Taiwan], National Central University [Taiwan] (NCU), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Operations Department (ESAC), European Space Astronomy Centre (ESAC), Agence Spatiale Européenne = European Space Agency (ESA)-Agence Spatiale Européenne = European Space Agency (ESA), Department of Information Engineering [Padova] (DEI), NASA Ames Research Center (ARC), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Center for Space and Habitability (CSH), University of Bern, Physikalisches Institut [Bern], Universität Bern [Bern] (UNIBE), Max-Planck-Institut für Sonnensystemforschung (MPS), Universita degli Studi di Padova, European Space Agency (ESA), Consiglio Nazionale delle Ricerche [Roma] (CNR), California Institute of Technology (CALTECH)-NASA, European Space Agency (ESA)-European Space Agency (ESA), Universität Bern [Bern], Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), ITA, USA, GBR, FRA, and DEU
Subjects: 67P/Churyumov-Gerasimenko, 010504 meteorology & atmospheric sciences, Epoch (astronomy), Comet, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Equinox, 01 natural sciences, Latitude, 0103 physical sciences, comets, Comets: individual: 67P/Churyumov, Gerasimenko, 010303 astronomy & astrophysics, Southern Hemisphere, 0105 earth and related environmental sciences, [PHYS]Physics [physics], Physics, Jet (fluid), biology, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], 520 Astronomy, Northern Hemisphere, Astronomy, Astronomy and Astrophysics, 620 Engineering, biology.organism_classification, 13. Climate action, Space and Planetary Science, Osiris, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: International audience; We used the OSIRIS camera system onboard the Rosetta spacecraft to monitor jet activity of comet 67P/Churyumov-Gerasimenko. With a monthly cadence, we covered an epoch from December 2014 to October 2015, thereby including the first equinox and the perihelion passage. Jet features were measured in individual images, which were used to perform a statistical inversion. The study provides maps for the locations of likeliest sources of jet activity on the comet’s surface as a function of time. The sources follow the sub-solar latitude, show clustering and a broadening of the activity band with time in the Northern hemisphere. On the Southern hemisphere they are not clustered but show a broader spread over all longitudes which is either related to the north-south dichotomy of the comet’s topography or due to a higher insolation during southern summer.
Published: 2017

123. Evidence of sub-surface energy storage in comet 67P from the outburst of 2016 July 03

Author: M. A. Barucci, Eberhard Grün, Giampiero Naletto, Ivano Bertini, M. De Cecco, Pedro Hasselmann, S. Mottola, Wing-Huen Ip, Laurent Jorda, Bernhard Geiger, Xian Shi, Maurizio Pajola, Jouni Rynö, Gabriele Cremonese, Oliver Stenzel, J. J. Lopez Moreno, J. L. Bertaux, J. Kissel, S. Höfner, M. F. A'Hearn, Olivier Groussin, Martin Hilchenbach, B. Zaprudin, Steve Boudreault, V. Da Deppo, Alessandra Rotundi, Ludmilla Kolokolova, Dennis Bodewits, Philippe Lamy, Jessica Agarwal, Marc Hofmann, Paul D. Feldman, Horst Uwe Keller, Stefano Debei, Sihane Merouane, J. Wm. Parker, Monica Lazzarin, Stubbe F. Hviid, Michael Küppers, Stavro Ivanovski, Cesare Barbieri, Jean-Baptiste Vincent, Francesco Marzari, Detlef Koschny, Yves Langevin, Sonia Fornasier, N. Oklay, L. M. Lara, Jakob Deller, Zhong-Yi Lin, A. Koch, Andrew J. Steffl, R. Rodrigo, Björn Davidsson, J.-R. Kramm, Carsten Güttler, E. Kührt, Cecilia Tubiana, Klaus Hornung, P. J. Gutierrez, Stephen C. Lowry, Jörg Knollenberg, Holger Sierks, Henning Fischer, Marco Fulle, V. Della Corte, A. Gicquel, Harold A. Weaver, Nicolas Thomas, Lori M. Feaga, Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Dipartimento di Scienze e Tecnologie [Napoli] (DIST), Università degli Studi di Napoli 'Parthenope' = University of Naples (PARTHENOPE), Department of Physics and Astronomy [Baltimore], Johns Hopkins University (JHU), European Space Astronomy Centre (ESAC), Agence Spatiale Européenne = European Space Agency (ESA), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Università degli Studi di Padova = University of Padua (Unipd), Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Kernphysik (MPIK), Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], Istituto di Astrofisica Spaziale e Fisica cosmica - Roma (IASF-Roma), Istituto Nazionale di Astrofisica (INAF), NASA Ames Research Center (ARC), Department of Space Studies [Boulder], Southwest Research Institute [Boulder] (SwRI), Physikalisches Institut [Bern], Universität Bern [Bern] (UNIBE), Dipartimento di Fisica e Astronomia 'Galileo Galilei', PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Padova (OAPD), CNR Institute for Photonics and Nanotechnologies (IFN), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Department of Industrial Engineering [Padova], INAF - Osservatorio Astronomico di Trieste (OAT), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Universität der Bundeswehr München [Neubiberg], DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], von Hoerner und Sulger GmbH, European Space Research and Technology Centre (ESTEC), Research and Scientific Support Department, ESTEC (RSSD), Agence Spatiale Européenne = European Space Agency (ESA)-Agence Spatiale Européenne = European Space Agency (ESA), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Centre for Astrophysics and Planetary Science [Canterbury] (CAPS), University of Kent [Canterbury], CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), Finnish Meteorological Institute (FMI), Johns Hopkins University Applied Physics Laboratory [Laurel, MD] (APL), Tuorla Observatory, University of Turku, Lowry, S.C., ITA, FRA, DEU, ESP, Centre National de la Recherche Scientifique (France), German Centre for Air and Space Travel, Agenzia Spaziale Italiana, Swedish National Space Board, Ministerio de Economía y Competitividad (España), European Space Agency, Max-Planck-Institut für Sonnensystemforschung (MPS), Universita degli studi di Napoli 'Parthenope' [Napoli], European Space Agency (ESA), Universita degli Studi di Padova, Universität Bern [Bern], Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Consiglio Nazionale delle Ricerche [Roma] (CNR), California Institute of Technology (CALTECH)-NASA, European Space Agency (ESA)-European Space Agency (ESA), and Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Asteroiden und Kometen, Solid state: refractory, Acceleration of particles, 010504 meteorology & atmospheric sciences, 01 natural sciences, law.invention, Astrobiology, Scattering, individual: 67P/Churyumov-Gerasimenko [Comets], law, Rosetta, 0103 physical sciences, Surface change, Astrophysics::Solar and Stellar Astrophysics, Sunrise, OSIRIS, Solid state: volatile, Crystallization, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Comets: individual: 67P/Churyumov-Gerasimenko, [PHYS]Physics [physics], Physics, ta115, 520 Astronomy, volatile [Solid state], general [Comets], Astronomy and Astrophysics, Solar illumination, 620 Engineering, Surface energy, Amorphous solid, Comets: general, On board, 13. Climate action, Space and Planetary Science, acceleration of particles, scattering, solid state: refractory, solid state: volatile, comets: general, comets: individual: 67P/Churyumov-Gerasimenko, Physics::Space Physics, Sublimation (phase transition), QB651, Astrophysics::Earth and Planetary Astrophysics, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], refractory [Solid state]
Abstract: On 2016 July 03, several instruments onboard ESA's Rosetta spacecraft detected signs of an outburst event on comet 67P, at a heliocentric distance of 3.32 au from the Sun, outbound from perihelion. We here report on the inferred properties of the ejected dust and the surface change at the site of the outburst. The activity coincided with the local sunrise and continued over a time interval of 14-68 min. It left a 10-m-sized icy patch on the surface. The ejected material comprised refractory grains of several hundred microns in size, and sub-micron-sized water ice grains. The high dust mass production rate is incompatible with the free sublimation of crystalline water ice under solar illumination as the only acceleration process. Additional energy stored near the surface must have increased the gas density. We suggest a pressurized sub-surface gas reservoir, or the crystallization of amorphous water ice as possible causes.© 2015 The Authors., The support of the national funding agencies of Germany (DLR, grant 50 QP 1302), France (CNES), Austria, Finland and the ESA Technical Directorate is gratefully acknowledged.
Published: 2017

124. Long-term survival of surface water ice on comet 67P

Author: Alice Lucchetti, M. De Cecco, R. Rodrigo, Michael Küppers, Laurent Jorda, Ivano Bertini, Nilda Oklay, W-H. Ip, Detlef Koschny, Marc Hofmann, J. L. Bertaux, Frank Scholten, Nicolas Thomas, J.-R. Kramm, V. Da Deppo, Clement Feller, P. J. Gutierrez, Dennis Bodewits, Sonia Fornasier, Carsten Güttler, I. Hall, Maurizio Pajola, Nafiseh Masoumzadeh, Francesco Marzari, Marco Fulle, A. Gicquel, M. A. Barucci, Jörg Knollenberg, Holger Sierks, Cesare Barbieri, Monica Lazzarin, Jakob Deller, Zhong-Yi Lin, David Kappel, Olivier Groussin, J. J. Lopez Moreno, Jean-Baptiste Vincent, Horst Uwe Keller, Michael F. A'Hearn, Luisa Lara, Giampiero Naletto, Pedro Hasselmann, Björn Davidsson, Cecilia Tubiana, Philippe Lamy, Antoine Pommerol, Stubbe F. Hviid, Hans Rickman, Frank Preusker, Xian Shi, Stefano Mottola, Gábor L. Kovács, Gabriele Cremonese, Ekkehard Kührt, J. D. P. Deshapriya, Stefano Debei, DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), NASA Ames Research Center (ARC), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Dipartimento di Fisica e Astronomia 'Galileo Galilei', Università degli Studi di Padova = University of Padua (Unipd), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), Department of Physics and Astronomy [Uppsala], Uppsala University, Space Research Centre of Polish Academy of Sciences (CBK), Polska Akademia Nauk = Polish Academy of Sciences (PAN), Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), CNR Institute for Photonics and Nanotechnologies (IFN), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Department of Industrial Engineering [Padova], University of Trento [Trento], INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Space Science [Taiwan], National Central University [Taiwan] (NCU), Operations Department (ESAC), European Space Astronomy Centre (ESAC), Agence Spatiale Européenne = European Space Agency (ESA)-Agence Spatiale Européenne = European Space Agency (ESA), Department of Information Engineering [Padova] (DEI), Physikalisches Institut [Bern], Universität Bern [Bern] (UNIBE), Max-Planck-Institut für Sonnensystemforschung (MPS), Universita degli Studi di Padova, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), European Space Agency (ESA), Consiglio Nazionale delle Ricerche [Roma] (CNR), European Space Agency (ESA)-European Space Agency (ESA), Universität Bern [Bern], and California Institute of Technology (CALTECH)-NASA
Subjects: Asteroiden und Kometen, 010504 meteorology & atmospheric sciences, Infrared, Comet, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Techniques: image processing, Narrow angle, Astrophysics, 01 natural sciences, Methods: data analysis, 0103 physical sciences, Long term survival, Techniques: imaging spectroscopy, Variation (astronomy), 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Comets: individual: 67P/Churyumov-Gerasimenko, Physics, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], 520 Astronomy, Leitungsbereich PF, Planetengeodäsie, Astronomy and Astrophysics, 620 Engineering, 13. Climate action, Space and Planetary Science, Water ice, Surface water
Abstract: Numerous water-ice-rich deposits surviving more than several months on comet 67P/Churyumov-Gerasimenko were observed during the Rosetta mission. We announce the first-time detection of water-ice features surviving up to 2 yr since their first observation via OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) NAC (narrow angle camera). Their existence on the nucleus of comet 67P at the arrival of the Rosetta spacecraft suggests that they were exposed to the surface during the comet's previous orbit. We investigated the temporal variation of large water-ice patches to understand the long-term sustainability of water ice on cometary nuclei on time-scales of months and years. Large clusters are stable over typical periods of 0.5 yr and reduce their size significantly around the comet's perihelion passage, while small exposures disappear. We characterized the temporal variation of their multispectral signatures. In large clusters, dust jets were detected, whereas in large isolated ones no associated activity was detected. Our thermal analysis shows that the long-term sustainability of water-ice-rich features can be explained by the scarce energy input available at their locations over the first half year. However, the situation reverses for the period lasting several months around perihelion passage. Our two end-member mixing analysis estimates a pure water-ice equivalent thickness up to 15 cm within one isolated patch, and up to 2 m for the one still observable through the end of the mission. Our spectral modelling estimates up to 48 per cent water-ice content for one of the large isolated feature, and up to 25 per cent water ice on the large boulders located within clusters.
Published: 2017

125. Modelling of the outburst on 2015 July 29 observed with OSIRIS cameras in the Southern hemisphere of comet 67P/Churyumov–Gerasimenko

Author: N. Oklay, Holger Sierks, Stefano Mottola, F. Preusker, Ivano Bertini, J.-R. Kramm, Géza Kovács, Jessica Agarwal, Michael Küppers, Nicolas Fougere, Giampiero Naletto, Matteo Massironi, F. Moreno, Mohamed Ramy El-Maarry, Hans Rickman, Sebastien Besse, Stephen C. Lowry, Stubbe F. Hviid, Monica Lazzarin, Xian Shi, L. M. Lara, A. Gicquel, Marco Fulle, S. Höfner, M. A. Barucci, J. B. Vincent, Jörg Knollenberg, M. F. A'Hearn, V. Da Deppo, Olivier Groussin, P. Gutiérrez-Marquez, Rafael Rodrigo, Francesco Marzari, Nafiseh Masoumzadeh, X. Hu, M. De Cecco, M. Rose, Ekkehard Kührt, Stefano Debei, Imre Toth, Cesare Barbieri, Björn Davidsson, Sonia Fornasier, Cecilia Tubiana, Jakob Deller, Gabriele Cremonese, Maurizio Pajola, Zhong-Yi Lin, F. Scholten, Wing-Huen Ip, Laurent Jorda, Detlef Koschny, Nicolas Thomas, P. J. Gutierrez, Marc Hofmann, Steve Boudreault, J. J. Lopez Moreno, Philippe Lamy, Dennis Bodewits, E. Frattin, Carsten Güttler, H. U. Keller, J. L. Bertaux, Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, PI-DSMC software package, DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Department of Climate and Space Sciences and Engineering (CLaSP), University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Università degli Studi di Padova = University of Padua (Unipd), Institute of Space Science [Taiwan], National Central University [Taiwan] (NCU), Dipartimento di Fisica e Astronomia 'Galileo Galilei', Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), International Space Science Institute [Bern] (ISSI), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), Space Research Centre of Polish Academy of Sciences (CBK), Polska Akademia Nauk = Polish Academy of Sciences (PAN), Department of Physics and Astronomy [Uppsala], Uppsala University, Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Research and Scientific Support Department, ESTEC (RSSD), Agence Spatiale Européenne = European Space Agency (ESA)-Agence Spatiale Européenne = European Space Agency (ESA), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), CNR Institute for Photonics and Nanotechnologies (IFN), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Department of Industrial Engineering [Padova], University of Trento [Trento], Physikalisches Institut [Bern], Universität Bern [Bern] (UNIBE), INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Department of Mechatronics, Optics and Mechanical Engineering Informatics (MOMEI), Budapest University of Technology and Economics [Budapest] (BME), European Space Astronomy Centre (ESAC), School of Physical Sciences [Canterbury], University of Kent [Canterbury], Department of Information Engineering [Padova] (DEI), NASA Ames Research Center (ARC), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), ITA, USA, GBR, FRA, DEU, Max-Planck-Institut für Sonnensystemforschung (MPS), Universita degli Studi di Padova, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), European Space Agency (ESA), European Space Agency (ESA)-European Space Agency (ESA), Consiglio Nazionale delle Ricerche [Roma] (CNR), Universität Bern [Bern], and California Institute of Technology (CALTECH)-NASA
Subjects: 010504 meteorology & atmospheric sciences, Infrared, Comet, Data analysis, Comets: individual: 67P/Churyumov-Gerasimenko, Methods: data analysis, Methods: numerical, Methods: observational, 67P/Churyumov, Coma (optics), Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, 01 natural sciences, modelling, comet, Rosetta, 0103 physical sciences, Comets, High spatial resolution, Astrophysics::Solar and Stellar Astrophysics, OSIRIS, 010303 astronomy & astrophysics, Southern Hemisphere, Observations, Astrophysics::Galaxy Astrophysics, Gerasimenko, 0105 earth and related environmental sciences, Numerical, [PHYS.PHYS.PHYS-AO-PH]Physics [physics]/Physics [physics]/Atmospheric and Oceanic Physics [physics.ao-ph], [PHYS]Physics [physics], Physics, 67P, biology, 520 Astronomy, outburt, Astronomy, Astronomy and Astrophysics, Radius, 620 Engineering, biology.organism_classification, Outgassing, 13. Climate action, Space and Planetary Science, Astrophysics::Earth and Planetary Astrophysics, Osiris, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: International audience; Images of the nucleus and the coma (gas and dust) of comet 67P/Churyumov– Gerasimenko have been acquired by the OSIRIS (Optical, Spectroscopic and Infrared Remote Imaging System) cameras since 2014 March using both the wide-angle camera and the narrow-angle camera (NAC). We use images from the NAC camera to study a bright outburst observed in the Southern hemisphere on 2015 July 29. The high spatial resolution of the NAC is needed to localize the source point of the outburst on the surface of the nucleus. The heliocentric distance is 1.25 au and the spacecraft–comet distance is 186 km. Aiming to better understand the physics that led to the outgassing, we used the Direct Simulation Monte Carlo method to study the gas flow close to the nucleus and the dust trajectories. The goal is to understand the mechanisms producing the outburst. We reproduce the opening angle of the outburst in the model and constrain the outgassing ratio between the outburst source and the local region. The outburst is in fact a combination of both gas and dust, in which the active surface is approximately 10 times more active than the average rate found in the surrounding areas. We need a number of dust particles 7.83 × 1011 to 6.90 × 1015 (radius 1.97–185 μm), which correspond to a mass of dust (220–21) × 103 kg.
Published: 2017

126. Gas outflow and dust transport of comet 67P/Churyumov–Gerasimenko

Author: Francesco Marzari, Wing-Huen Ip, Laurent Jorda, J. Rainer Kramm, Hans Rickman, Gábor L. Kovács, Marc Hofmann, I. L. Lai, Philippe Lamy, Detlef Koschny, Jong-Shinn Wu, Mariolino De Cecco, Nilda Oklay, Ivano Bertini, Michael Küppers, Xian Shi, Nicolas Thomas, Stubbe F. Hviid, Jean-Loup Bertaux, Holger Sierks, C. Güttler, Olivier Groussin, Vania Da Deppo, Marco Fulle, Steven Boudreault, Pedro J. Gutiérrez, Giampiero Naletto, M. A. Barucci, Horst Uwe Keller, Michael F. A'Hearn, Jose J. Lopez Moreno, Jui Chi Lee, Ying Liao, Cesare Barbieri, Luisa Lara, Monica Lazzarin, Cheng Chin Su, Jean-Baptiste Vincent, Jakob Deller, Gabriele Cremonese, Ekkehard Kührt, Zhong-Yi Lin, Björn Davidsson, Cecilia Tubiana, Stefano Debei, Jessica Agarwal, Sonia Fornasier, Jörg Knollenberg, Rafael Rodrigo, Institute of Space Science [Taiwan], National Central University [Taiwan] (NCU), Institute of Astronomy [Taiwan] (IANCU), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Department of Mechanical Engineering [NCTU], National Chiao Tung University (NCTU), Department of Atmospheric Sciences [Taoyuan City], Physikalisches Institut [Bern], Universität Bern [Bern], Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Dipartimento di Fisica e Astronomia 'Galileo Galilei', Universita degli Studi di Padova, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Department of Physics and Astronomy [Uppsala], Uppsala University, Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), CNR Institute for Photonics and Nanotechnologies (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), Department of Industrial Engineering [Padova], University of Trento [Trento], INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), European Space Astronomy Centre (ESAC), Department of Information Engineering [Padova] (DEI), Universität Bern [Bern] (UNIBE), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Università degli Studi di Padova = University of Padua (Unipd), Agence Spatiale Européenne = European Space Agency (ESA), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), ITA, USA, GBR, FRA, and DEU
Subjects: individual: comet 67P/Churyumov-Gerasimenko [comets], 010504 meteorology & atmospheric sciences, Astrophysics::High Energy Astrophysical Phenomena, Comet dust, Irregular shape, Comet, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, general [comets], methods: numerical, Astronomi, astrofysik och kosmologi, 0103 physical sciences, Comets: general, Comets: individual: comet 67P/Churyumov-Gerasimenko, Methods: numerical, Astronomy and Astrophysics, Space and Planetary Science, Astronomy, Astrophysics and Cosmology, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Physics, Jet (fluid), [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Comet tail, 520 Astronomy, comets: general, Thermal cycle, Astronomy, numerical [methods], comets: individual: comet 67P/Churyumov-Gerasimenko, 620 Engineering, 13. Climate action, Outflow, Astrophysics::Earth and Planetary Astrophysics
Abstract: International audience; Because of the diurnal thermal cycle and the irregular shape of the nucleus, gas outflow of comet 67P/Churyumov–Gerasimenko could be highly anisotropic as indicated by the colliminated dust jet structures on the sunlit side. Based on the OSIRIS imaging observations of the outgassing effect, a simple model of surface sublimation can be constructed by taking into account the dependence on the solar insolation. With preliminary information on the time variability of the global gas production rate, a sequence of gas coma models can be generated at different epochs before and after perihelion. We also investigate different patterns of dust particle dynamics under the influences of nuclear rotation and gas drag. From these considerations, a consistent picture of the spatial distribution of dusty materials across the surface of comet 67P as it moves around the perihelion can be developed. It is found that because of the redeposition of the ejected dust from the Southern hemisphere to the Northern hemisphere during the southern summer season the Hapi region could gain up to 0.4 m while the Wosret region would lose up to 1.8 m of dust mantle per orbit.
Published: 2016

127. Coronal Mass Ejections over Solar Cycles 23 and 24

Author: Philippe Lamy, Julien Wojak, Brice Boclet, Olivier Floyd, T. Barlyaeva, Hugo Gilardy, HELIOS - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Institut FRESNEL (FRESNEL), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Centro de Investigação da Terra e do Espaço da UC (CITEUC), Universidade de Coimbra [Coimbra], Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Physics, Sunspot, education.field_of_study, 010504 meteorology & atmospheric sciences, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Population, Sun, Northern Hemisphere, Astronomy and Astrophysics, Astrophysics, Kinetic energy, 01 natural sciences, Solar prominence, Bimodality, Latitude, Space and Planetary Science, 0103 physical sciences, Coronal mass ejections, Coronal mass ejection, Corona, education, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences
Abstract: International audience; We present a statistical analysis of solar coronal mass ejections (CMEs) based on 23 years of quasi-continuous observations with the LASCO coronagraph, thus covering two complete Solar Cycles (23 and 24). We make use of five catalogs, one manual (CDAW) and four automated (ARTEMIS, CACTus, SEEDS, and CORIMP), to characterize the temporal evolutions and distributions of their properties: occurrence and mass rates, waiting times, periodicities, angular width, latitude, speed, acceleration and kinetic energy. Our analysis points to inevitable discrepancies between catalogs due to the complex nature of CMEs and to the different techniques implemented to detect them, but also to large areas of convergence that are critically important to ascertain the reliability of the results. The temporal variations of these properties are compared to four indices/proxies of solar activity: the radio flux at 10.7 cm (F10.7), the international sunspot number (SSN), the sunspot area (SSA), and the total magnetic field (TMF), either globally or separately in the northern and southern hemispheres in the case of the last three. We investigate the association of CMEs with flares, erupting prominences, active regions and streamers. We find that the CME occurrence and mass rates globally track the indices/proxies of solar activity with no time lag, prominently the radio flux F10.7, but the linear relationships were different during the two solar cycles, implying that the CME rates were relatively larger during SC 24 than during SC 23. However, there exists a pronounced divergence of the CME rates in the northern hemisphere during SC 24 as these rates were substantially larger than predicted by the temporal variation of the sunspot number. The distribution of kinetic energy follows a log-normal law and that of angular width follows an exponential law implying that they are random and independent. The distribution of waiting time (WTD) has a long power-law tail extending from 3 to 100 hr with a power-law index which varies with the solar cycle, thus reflecting the temporal variability of the process of CME formation. There is very limited evidence for periodicities in the occurrence and mass rates of CMEs, a striking feature being the dichotomy between the two hemispheres. Rather weak correlations are present among the various CME parameters and particularly none between speed and acceleration. The association of CMEs with flares and erupting prominences involves only a few percents of the overall population of CMEs but the associated CMEs have distinctly larger mass, speed, kinetic energy and angular width. A more pronounced association is found with active regions but the overwhelming one is with streamers further confirmed by the similarity between the heliolatitudinal distribution of CMEs and that of the electron density reconstructed from time-dependent tomographic inversion. We find no evidence of bimodality in the distributions of physical parameters that would support the existence of two classes, particularly that based on speed and acceleration, the distributions thus favoring a continuum of properties. There exists an excess of narrows CMEs which however does not define a special class. These narrow CMEs are likely associated with the ubiquitous mini-filaments eruptions and with mini flux ropes originating from small magnetic bipoles, the disruption mechanisms being similar to those launching larger CMEs. This supports the concept that CMEs at large arise from closed-field coronal regions at both large and small scales.
Published: 2019

128. Tomography of the Solar Corona with the Wide-Field Imager for the Parker Solar Probe

Author: Bart van der Holst, Alberto M. Vásquez, Angelos Vourlidas, Ward B. Manchester, Philippe Lamy, Russell A. Howard, Richard A. Frazin, Instituto de Astronomía y Física del Espacio [Buenos Aires] (IAFE), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)-Universidad de Buenos Aires [Buenos Aires] (UBA), Department of Climate and Space Sciences and Engineering (CLaSP), University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Johns Hopkins University Applied Physics Laboratory [Laurel, MD] (APL), Space Science Division [Washington], Naval Research Laboratory (NRL), HELIOS - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), and Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)
Subjects: Brightness, Electron density, Spectrum visible, 010504 meteorology & atmospheric sciences, Astrophysics, Solar cycle, 01 natural sciences, models, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, Physics, Tomographic reconstruction, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Astronomy and Astrophysics, Corona, Orbit, Cover (topology), Space and Planetary Science, Physics::Space Physics, Astrophysics::Earth and Planetary Astrophysics, Tomography
Abstract: The Wide-field Imager for the Parker Solar Probe (PSP/WISPR) comprises two telescopes that record white-light total brightness $[B]$ images of the solar corona. Their fields of view cover a widely changing range of heliocentric heights over the 24 highly eccentric orbits planned for the mission. In this work, the capability of PSP/WISPR data to carry out tomographic reconstructions of the three-dimensional (3D) distribution of the coronal electron density is investigated. Based on the precise orbital information of the mission, $B$-images for Orbits 1, 12, and 24 are synthesized from a 3D magnetohydrodynamic model of the corona. For each orbit, the time series of synthetic images is used to carry out a tomographic reconstruction of the coronal electron density and results are compared with the model. As the PSP perihelion decreases, the range of heights that can be tomographically reconstructed progressively shifts to lower values, and the period required to gather the data decreases. For Orbit 1 tomographic reconstruction is not possible. For Orbit 12, tomographic reconstruction is possible in the heliocentric height range ${\approx}\, 5\,\mbox{--}\,15~\mathrm{{R}_{\odot}}$, over a region spanning up to ${\approx}\,160^{\circ}$ in Carrington longitude, with data gathered over a ${\approx}\, 3.4$ day-long period. For Orbit 24, tomographic reconstruction is possible in the heliocentric height range ${\approx}\,3\,\mbox{--}\,10~\mathrm {R}_{\odot}$, over a region spanning up to ${\approx} \,170^{\circ}$ in Carrington longitude, with data gathered over a ${\approx}\, 2.8$ day-long period.
Published: 2019

129. Early Detection of Metastatic Relapse and Monitoring of Therapeutic Efficacy by Ultra-Deep Sequencing of Plasma Cell-Free DNA in Patients With Urothelial Bladder Carcinoma

Author: Ryan Swenerton, Lars Dyrskjøt, Dina Hafez, Zoe June Assaf, Alexey Aleshin, Mads Agerbæk, Samantha Navarro, Hsin-Ta Wu, Claus L. Andersen, Ramya Srinivasan, Emil Christensen, Antony Tin, Scott Dashner, Iver Nordentoft, Mustafa Balcioglu, Jørgen Bjerggaard Jensen, Karin Birkenkamp-Demtröder, Styrmir Sigurjonsson, Michael Knudsen, Sia Viborg Lindskrog, Bernhard Zimmermann, Philippe Lamy, Cheng-Ho Jimmy Lin, Ann Taber, Søren Vang, Alexander Olson, Thomas Reinert, Raheleh Salari, Svetlana Shchegrova, Himanshu Sethi, Shruti Sharma, Rosalyn Ram, Matthew Rabinowitz, and Paul Billings
Subjects: 0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, MEDLINE, Early detection, SOMATIC ERCC2 MUTATIONS, Plasma cell, Free dna, 03 medical and health sciences, CISPLATIN, NEOADJUVANT CHEMOTHERAPY, 0302 clinical medicine, Text mining, Recurrence, Internal medicine, medicine, Carcinoma, Humans, In patient, Longitudinal Studies, Neoplasm Metastasis, RECURRENCE, Early Detection of Cancer, TREATMENT RESPONSE, business.industry, CIRCULATING TUMOR DNA, Ultra deep sequencing, medicine.disease, Prognosis, CANCER, CLONAL EVOLUTION, Editorial Commentary, 030104 developmental biology, medicine.anatomical_structure, Urinary Bladder Neoplasms, 030220 oncology & carcinogenesis, Female, Neoplasm Recurrence, Local, business, LIQUID BIOPSIES, Cell-Free Nucleic Acids
Abstract: PURPOSE Novel sensitive methods for early detection of relapse and for monitoring therapeutic efficacy may have a huge impact on risk stratification, treatment, and ultimately outcome for patients with bladder cancer. We addressed the prognostic and predictive impact of ultra-deep sequencing of cell-free DNA in patients before and after cystectomy and during chemotherapy. PATIENTS AND METHODS We included 68 patients with localized advanced bladder cancer. Patient-specific somatic mutations, identified by whole-exome sequencing, were used to assess circulating tumor DNA (ctDNA) by ultra-deep sequencing (median, 105,000×) of plasma DNA. Plasma samples (n = 656) were procured at diagnosis, during chemotherapy, before cystectomy, and during surveillance. Expression profiling was performed for tumor subtype and immune signature analyses. RESULTS Presence of ctDNA was highly prognostic at diagnosis before chemotherapy (hazard ratio, 29.1; P = .001). After cystectomy, ctDNA analysis correctly identified all patients with metastatic relapse during disease monitoring (100% sensitivity, 98% specificity). A median lead time over radiographic imaging of 96 days was observed. In addition, for high-risk patients (ctDNA positive before or during treatment), the dynamics of ctDNA during chemotherapy was associated with disease recurrence ( P = .023), whereas pathologic downstaging was not. Analysis of tumor-centric biomarkers showed that mutational processes (signature 5) were associated with pathologic downstaging ( P = .024); however, no significant correlation for tumor subtypes, DNA damage response mutations, and other biomarkers was observed. Our results suggest that ctDNA analysis is better associated with treatment efficacy compared with other available methods. CONCLUSION ctDNA assessment for early risk stratification, therapy monitoring, and early relapse detection in bladder cancer is feasible and provides a basis for clinical studies that evaluate early therapeutic interventions.
Published: 2019

130. Multidisciplinary analysis of the Hapi region located on Comet 67P/Churyumov–Gerasimenko

Author: Wing-Huen Ip, Philippe Lamy, Carsten Güttler, F. La Forgia, Nilda Oklay, R. Rodrigo, Z. Y. Lin, Dennis Bodewits, Stefano Debei, V. Da Deppo, H. U. Keller, Luca Penasa, Jakob Deller, Maurizio Pajola, Alice Lucchetti, Gabriele Cremonese, Giampiero Naletto, Sonia Fornasier, Detlef Koschny, Marco Fulle, P. J. Gutierrez, M. De Cecco, Holger Sierks, J. J. Lopez Moreno, Francesco Marzari, J.-C. Lee, Matteo Massironi, F. Preusker, Ivano Bertini, Stubbe F. Hviid, Sabrina Ferrari, Imre Tóth, Jessica Agarwal, Pamela Cambianica, Xian Shi, Frank Scholten, Lorenza Giacomini, Jean-Loup Bertaux, M. A. Barucci, Stefano Mottola, Luisa Lara, Björn Davidsson, M. R. El Maarry, Clement Feller, Cecilia Tubiana, Monica Lazzarin, Jean-Baptiste Vincent, INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Department of Atmospheric Sciences [Taoyuan City], National Central University [Taiwan] (NCU), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Universita degli Studi di Padova, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Dipartimento di Geoscienze [Padova], Dipartimento di Fisica e Astronomia 'Galileo Galilei', CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), Institute of Space Science [Taiwan], Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), IMPEC - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centro de Astrobiologia [Madrid] (CAB), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), International Space Science Institute [Bern] (ISSI), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Space Research Institute of the Russian Academy of Sciences (IKI), Russian Academy of Sciences [Moscow] (RAS), Department of Physics [Auburn], Auburn University (AU), Department of Mechanical Engineering [Padova], Department of Industrial Engineering [Padova], Universita degli Studi di Padova-Universita degli Studi di Padova, University of Trento [Trento], Laboratory for Atmospheric and Space Physics [Boulder] (LASP), University of Colorado [Boulder], INAF - Osservatorio Astronomico di Trieste (OAT), Institut d'Astronomie et d'Astrophysique [Bruxelles] (IAA), Université Libre de Bruxelles [Bruxelles] (ULB), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), European Space Agency, Swedish National Space Board, Ministerio de Educación y Ciencia (España), Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, German Centre for Air and Space Travel, Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737, Pajola, M. [0000-0002-3144-1277], Penasa, L. [0000-0002-6394-3108], Fornasier, S. [0000-0001-7678-3310], Lucchetti, A. [0000-0001-7413-3058], Vicent, J. B. [0000-0001-6575-3079], Naletto, G. [0000-0003-2007-3138], Barucci, M. A. [0000-0002-1345-0890], Bertaux, J. L. [0000-0003-0333-229X], Deller, J. [0000-0001-8341-007X], Fulle, M. [0000-0001-8435-5287], Güttler, C. [0000-0003-4277-1738], Tubiana, C. [0000-0001-8475-9898], Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), California Institute of Technology (CALTECH)-NASA, PLANETO - LATMOS, Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Université libre de Bruxelles (ULB), Agenzia Spaziale Italiana (ASI), Swedish National Space Agency (SNSA), Deutsches Zentrum für Luft- und Raumfahrt (DLR), and Centre National D'Etudes Spatiales (CNES)
Subjects: Asteroiden und Kometen, statistical [Methods], Comet, individual (67P C-G) [Comets], Comets: individual (67P C-G), Methods: data analysis, Methods: statistical, 01 natural sciences, Methods statistical, Gravitational potential, 0103 physical sciences, data analysis [Methods], 010303 astronomy & astrophysics, Southern Hemisphere, Physics, geography, geography.geographical_feature_category, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 010308 nuclear & particles physics, Multidisciplinary analysis, Planetengeodäsie, 67P/Churyumov–Gerasimenko Comets Rosetta Hapi, Northern Hemisphere, Astronomy, Astronomy and Astrophysics, methods: data analysis –methods: statistical – comets: individual (67P C-G), Space and Planetary Science, Ridge, individual: 67P C-G [Comets], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: By using the Rosetta/OSIRIS-NAC data set taken in 2014 August, we focus on the neck region, called Hapi, located on 67P Churyumov-Gerasimenko's Northern hemisphere. The gravitational potential and slopes of Hapi, coupled with the geological unit identification and the boulder size-frequency distributions, support the interpretation that both taluses and gravitational accumulation deposits observable on Hapi are the result of multiple cliff collapses that occurred at different times. By contrast, the fine-particle deposits observable in the central part of the study area are made of aggregates coming from the Southern hemisphere and deposited during each perihelion passage. Both the consolidated terrains on the western part of Hapi, as well as the centrally aligned ridge made of boulder-like features, suggest that Hapi is in structural continuity with the onion-like structure of the main lobe of 67P. Despite the dusty blanket observable on Hapi, its terrains are characterized by water-ice-rich components that, once repeatedly and rapidly illuminated, sublimate, hence resulting in the strong jet activity observed in 2014 August.© 2019 The Author(s)., The support of the national funding agencies of Germany (DLR), Italy (ASI), France (CNES), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged.
Published: 2019

131. The shape of (7) Iris as evidence of an ancient large impact?

Author: Miroslav Brož, Philippe Lamy, Anna Marciniak, Josef Ďurech, J. Grice, M. Pajuelo, Paolo Tanga, Patrick Michel, Benoit Carry, Marin Ferrais, Emmanuel Jehin, Bin Yang, Alexis Drouard, Toni Santana-Ros, Frédéric Vachier, Franck Marchis, Michael Marsset, Matti Viikinkoski, Josef Hanus, Romain Fétick, Olivier Witasse, Christophe Dumas, J. Berthier, François Colas, Julie Castillo-Rogez, Agnieszka Kryszczyńska, Tadeusz Michalowski, Mikko Kaasalainen, Grzegorz Dudziński, Pierre Vernazza, Przemyslaw Bartczak, E. Podlewska-Gaca, Mirel Birlan, Thierry Fusco, H. Le Coroller, Arthur Vigan, Laurent Jorda, Fabrice Cipriani, Astronomical Institute of Charles University, Charles University [Prague] (CU), Department of Earth, Atmospheric and Planetary Sciences [MIT, Cambridge] (EAPS), Massachusetts Institute of Technology (MIT), Astrophysics Research Centre [Belfast] (ARC), Queen's University [Belfast] (QUB), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Department of Mathematics [Tampere], Tampere University of Technology [Tampere] (TUT), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), DOTA, ONERA, Université Paris Saclay (COmUE) [Châtillon], ONERA-Université Paris Saclay (COmUE), Search for Extraterrestrial Intelligence Institute (SETI), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Astronomical Observatory [Poznan], Adam Mickiewicz University in Poznań (UAM), West Pomeranian University of Technology in Szczecin (ZUT), Institut d'Astrophysique et de Géophysique [Liège], Université de Liège, The Open University [Milton Keynes] (OU), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), TMT International Observatory, Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru (PUCP), European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Technical University of Szczecin (TUNIV), Technical university of Szczecin, European Space Agency (ESA), TMT Observatory, and Pontificia Universidad Católica del Perú (PUCP)
Subjects: Solar System, Planetesimal, 010504 meteorology & atmospheric sciences, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], FOS: Physical sciences, Context (language use), Astrophysics, 01 natural sciences, methods: numerical, Impact crater, Angular diameter, 0103 physical sciences, medicine, Iris (anatomy), 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Physics, Earth and Planetary Astrophysics (astro-ph.EP), [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Collisional family, Astronomy and Astrophysics, 15. Life on land, medicine.anatomical_structure, 13. Climate action, Space and Planetary Science, Asteroid, [SDU]Sciences of the Universe [physics], minor planets, asteroids: individual: 7 Iris, methods: observational, Astrophysics - Earth and Planetary Astrophysics
Abstract: Asteroid (7) Iris is an ideal target for disk-resolved imaging owing to its brightness (V$\sim$7-8) and large angular size of 0.33 arcsec during its apparitions. Iris is believed to belong to the category of large unfragmented asteroids that avoided internal differentiation, implying that its current shape and topography may record the first few 100 Myr of the solar system's collisional evolution. We recovered information about the shape and surface topography of Iris from disk-resolved VLT/SPHERE/ZIMPOL images acquired in the frame of our ESO large program. We used the All-Data Asteroid Modeling (ADAM) shape reconstruction algorithm to model the 3D shape of Iris, using optical disk-integrated data and disk-resolved images from SPHERE as inputs. We analyzed the SPHERE images to infer the asteroid's global shape and the morphology of its main craters. We present the volume-equivalent diameter D$_{{\rm eq}}$=214$\pm$5 km, and bulk density $\rho$=2.7$\pm$0.3 g cm$^{-3}$ of Iris. Its shape appears to be consistent with that of an oblate spheroid with a large equatorial excavation. We identified eight putative surface features 20--40 km in diameter detected at several epochs, which we interpret as impact craters. Craters on Iris have depth-to-diameter ratios that are similar to those of analogous 10 km craters on Vesta. The bulk density of Iris is consistent with that of its meteoritic analog, namely LL ordinary chondrites. Considering the absence of a collisional family related to Iris and the number of large craters on its surface, we suggest that its equatorial depression may be the remnant of an ancient (at least 3 Gyr) impact. Iris's shape further opens the possibility that large planetesimals formed as almost perfect oblate spheroids. Finally, we attribute the difference in crater morphology between Iris and Vesta to their different surface gravities., Comment: Accepted for publication in Astronomy and Astrophysics
Published: 2019

132. APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer

Author: Isabelle Bernard-Pierrot, Lars Dyrskjøt, François Radvanyi, Jie Yang, Chun-Long Chen, Ludmila Prokunina-Olsson, Philippe Lamy, Aura Moreno-Vega, A. Rouf Banday, Ming Jun Shi, Xiang Yu Meng, Compartimentation et dynamique cellulaires (CDC), Institut Curie-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay, Génomique Fonctionnelle des Tumeurs Solides (U1162), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dynamique de l'information génétique : bases fondamentales et cancer (DIG CANCER), Aarhus University Hospital, PSL Research University (PSL), This work was supported by a grant from Ligue Nationale Contre le Cancer (IBP, FR, MJS, XYM, AMV) as an associated team (Equipe labellisée). MJS was supported by a scholarship from China Scholarship Council. XYM was supported by a fellowship from AVIESAN ITMO-cancer INSERM. ARB and LPO were supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, USA. PL and LD were supported by Aarhus University, Denmark., Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Sorbonne Université (SU), and Université Paris sciences et lettres (PSL)
Subjects: APOBEC, Urology, 030232 urology & nephrology, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Minor Histocompatibility Antigens, Upper urinary tract cancer, 03 medical and health sciences, 0302 clinical medicine, Aminohydrolases, Cytidine Deaminase, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], APOBEC Deaminases, Humans, Receptor, Fibroblast Growth Factor, Type 3, Medicine, Gene family, Neoplasm Invasiveness, Gene, Genetics, Bladder cancer, Sequence Analysis, RNA, business.industry, FGFR3 mutation, Proteins, upper urinary tract cancer, medicine.disease, Lynch syndrome, In vitro, 3. Good health, Urinary Bladder Neoplasms, Mutagenesis, 030220 oncology & carcinogenesis, Coding strand, Mutation, business
Abstract: FGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most common recurrent FGFR3 mutation, S249C (TCC → TGC), represents an APOBEC-type motif and is probably caused by the APOBEC-mediated mutagenic process, accounting for its over-representation. We observed significant enrichment of the APOBEC mutational signature and overexpression of AID/APOBEC gene family members in bladder tumors with S249C compared to tumors with other recurrent FGFR3 mutations. Analysis of replication fork directionality suggests that the coding strand of FGFR3 is predominantly replicated as a lagging strand template that could favor the formation of hairpin structures, facilitating mutagenic activity of APOBEC enzymes. In vitro APOBEC deamination assays confirmed S249 as an APOBEC target. We also found that the FGFR3 S249C mutation was common in three other cancer types with an APOBEC mutational signature, but rare in urothelial tumors without APOBEC mutagenesis and in two diseases probably related to aging. Patient summary: We propose that APOBEC-mediated mutagenesis can generate clinically relevant driver mutations even within suboptimal motifs, such as in the case of FGFR3 S249C, one of the most common mutations in bladder cancer. Knowledge about the etiology of this mutation will improve our understanding of the molecular mechanisms of bladder cancer. We propose that APOBEC-mediated mutagenesis can generate clinically relevant driver mutations, even within suboptimal motifs, such as in the case of FGFR3 S249C, one of the most common mutations in bladder cancer. Knowledge about the etiology of this mutation will improve our understanding of molecular mechanisms of bladder cancer.
Published: 2019

133. Pronounced morphological changes in a southern active zone on comet 67P/Churyumov-Gerasimenko

Author: Pedro Hasselmann, Giampiero Naletto, Carsten Güttler, Horst Uwe Keller, Detlef Koschny, Philippe Lamy, J. M. Sunshine, J. D. P. Deshapriya, L. M. Lara, Francesco Marzari, M. De Cecco, S. Fornasier, R. Rodrigo, Holger Sierks, V. Da Deppo, Monica Lazzarin, G. Cremonese, Marco Fulle, Ivano Bertini, Björn Davidsson, Dennis Bodewits, P. J. Gutierrez, Cecilia Tubiana, Stefano Debei, Van H. Hoang, Xian Shi, M. A. Barucci, W-H. Ip, Clement Feller, J.-L. Bertaux, Dominique Bockelée-Morvan, J. J. Lopez-Moreno, Jakob Deller, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Institute of Physics [Hanoi], Vietnam Academy of Science and Technology (VAST), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Università degli Studi di Padova = University of Padua (Unipd), Dipartimento di Fisica e Astronomia 'Galileo Galilei', CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), Research and Scientific Support Department, ESTEC (RSSD), European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA)-Agence Spatiale Européenne = European Space Agency (ESA), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Department of Physics [Auburn], Auburn University (AU), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), CNR Institute for Photonics and Nanotechnologies (IFN), Department of Industrial Engineering [Padova], INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Planetary Science Institute [Tucson] (PSI), University of Trento [Trento], ANR-17-CE31-0004,CLASSY,Composition des surfaces du Système Solaire de bas albédo(2017), German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Sonnensystemforschung (MPS), Universita degli Studi di Padova, Consiglio Nazionale delle Ricerche [Roma] (CNR), IMPEC - LATMOS, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), European Space Agency (ESA)-European Space Agency (ESA), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Technische Universität Braunschweig [Braunschweig], Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), and California Institute of Technology (CALTECH)-NASA
Subjects: 67P/Churyumov-Gerasimenko - methods, 010504 meteorology & atmospheric sciences, Comet, Individual, Astrophysics, Fault scarp, 01 natural sciences, Indirect evidence, individual: 67P/Churyumov-Gerasimenko [Comets], 0103 physical sciences, High spatial resolution, Comets, Active zone, miscellaneous [methods], 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Miscellaneous, Physics, Comets: individual: 67P/Churyumov-Gerasimenko, [PHYS]Physics [physics], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Astronomy and Astrophysics, Geodesy, 13. Climate action, Space and Planetary Science, methods: miscellaneous, Falling (sensation), [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Production rate
Abstract: Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., A smooth deposit in the southern Khonsu region has been seen in ESA/Rosetta observations as active during the second half of 2015, when the southern summer coincided with the perihelion passage of 67P/Churyumov-Gerasimenko (67P). Image color sequences acquired by the OSIRIS instrument in the period of January 2015 to July 2016, pre- and post-perihelion, show the occurrence of several small transient events as well as three massive outbursts (-10 to 1500 tons). High spatial resolution images taken one year and a half apart allowed us to track a variety of sources: the formation of cavities that are 1.3-14 m deep, ice-enriched patches, scarp retraction, and a second 50 m-wide boulder. We then estimated their masses and the dust mass of their corresponding plumes and outbursts. In particular, the deformation left by that boulder and its lack of talus may provide evidence for the lifting and subsequent falling back to the surface of large blocks. We calculate that a minimum vapor production rate of 1.4 x 10(24) m(-2) s(-1) is required to lift such an object. The comparison of the masses that are lost in the new cavities to the dust mass of outbursts gives indirect evidence of highly volatile ice pockets underneath. The spectrophotometric analysis and boulder counting also provides evidence for cavities that formed only 30 m apart with different spectral slopes, two long-standing ice patches, and local variations in the boulder-size frequency distribution. All this points to sub-surface ice pockets with different degrees of depth. Finally, the total mass of the morphological changes compared to most recent calculations of the total released mass by activity on 67P is estimated to be between 1.5 and 4.2%. This means that as many as about 25 similar active zones across the nucleus would be enough to sustain the entire cometary activity.© P. H. Hasselmann et al. 2019, P.H.H. would like to thank Alice Bernard for her support. This work was funded by the DIM-ACAV project (Ile-de-France). OSIRIS was built by a consortium of the Max-Planck-Institut fur Sonnensystemforschung, Gottingen, Germany, CISAS-University of Padova, Italy, the Laboratoire d'Astrophysique de Marseille, France, the Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, the Research and Scientific Support Department of the European Space Agency, Noordwijk, The Netherlands, the Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, the Universidad Politechnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut fur Datentechnik und Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged. We acknowledge the financial support from the France Agence Nationale de la Recherche (programme Classy, ANR-17-CE31-0004).
Published: 2019

134. The backscattering ratio of comet 67P/Churyumov-Gerasimenko dust coma as seen by OSIRIS onboard Rosetta

Author: Pamela Cambianica, F. La Forgia, Jean-Loup Bertaux, P. J. Gutierrez, Alice Lucchetti, E. Frattin, Alessandra Rotundi, Detlef Koschny, Pedro Hasselmann, Xian Shi, Wing-Huen Ip, Giovanna Rinaldi, Philippe Lamy, Carsten Güttler, Giampiero Naletto, Stefano Mottola, Monica Lazzarin, Marco Fulle, J. J. Lopez Moreno, Sabrina Ferrari, Nafiseh Masoumzadeh, M. A. Barucci, H. U. Keller, D. Guirado, Imre Toth, V. Petropoulou, Gábor L. Kovács, Holger Sierks, Gabriele Cremonese, M. De Cecco, Cesare Barbieri, L. M. Lara, Björn Davidsson, Jakob Deller, Dennis Bodewits, S. Ivanovsky, Francesca Ferri, Cecilia Tubiana, Luca Penasa, Jessica Agarwal, Stefano Debei, Ivano Bertini, Maurizio Pajola, Olga Muñoz, Francesco Marzari, S. Fornasier, Matteo Massironi, F. Moreno, R. Rodrigo, V. Da Deppo, German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Ministerio de Educación y Ciencia (España), Swedish National Space Agency, European Space Agency, Dipartimento di Fisica e Astronomia 'Galileo Galilei', Universita degli Studi di Padova, INAF - Osservatorio Astronomico di Trieste (OAT), Istituto Nazionale di Astrofisica (INAF), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Dipartimento di Scienze e Tecnologie [Napoli] (DIST), Universita degli studi di Napoli 'Parthenope' [Napoli], INAF - Osservatorio Astronomico di Padova (OAPD), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Department of Physics [Auburn], Auburn University (AU), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CNR Institute for Photonics and Nanotechnologies (IFN), Department of Industrial Engineering [Padova], University of Trento [Trento], Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Dipartimento di Geoscienze [Padova], Fulle, M. [0000-0001-8435-5287], Tubiana, C. [0000-0001-8475-9898], Güttler, C. [0000-0003-4277-1738], Pajola, M. [0000-0002-3144-1277], Rinaldi, G. [0000-0002-2968-0455], Naletto, G. [0000-0003-2007-3138], Barucci, M. A. [0000-0002-1345-0890], Bertaux, J. L. [0000-0003-0333-229X], Deller, J. [0000-0001-8341-007X], Fornasier, S. [0000-0001-7678-3310], Penasa, L. [0000-0002-6394-3108], Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), IMPEC - LATMOS, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), NASA-California Institute of Technology (CALTECH), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Technische Universität Braunschweig [Braunschweig], Università degli Studi di Padova = University of Padua (Unipd), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Università degli Studi di Napoli 'Parthenope' = University of Naples (PARTHENOPE), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Agence Spatiale Européenne = European Space Agency (ESA), and Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737
Subjects: 67P/Churyumov-Gerasimenko, Asteroiden und Kometen, 010504 meteorology & atmospheric sciences, photometry, Comet, data analysis, scattering –methods: data analysis – techniques: image processing – techniques: photometric – comets: individual: 67P/Churyumov-Gerasimenko, techniques: image processing, Astrophysics, 01 natural sciences, Photometry (optics), Scattering, techniques: photometric, individual: 67P/Churyumov-Gerasimenko [Comets], 0103 physical sciences, Churyumov–Gerasimenko, image processing [Techniques], data analysis [Methods], 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Physics, biology, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], scattering, methods: data analysis, techniques: image processing, techniques: photometric, comets: individual: 67P/Churyumov-Gerasimenko, Phase angle, scattering, photometric [Techniques], comets: individual: 67P/Churyumov-Gerasimenko, Astronomy and Astrophysics, biology.organism_classification, methods: data analysis, image processing, 13. Climate action, Space and Planetary Science, Drag, Temporal resolution, Inverse scattering problem, Osiris, individual: 67P [Comets], [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: Remote sensing observations of dust particles ejected from comets provide important hints on the intimate nature of the materials composing these primitive objects. The measurement of dust coma backscattering ratio, BSR, defined as the ratio of the reflectance at phase angle 0 ◦ and 30 ◦ , helps tuning theoretical models aimed at solving the inverse scattering problem deriving information on the nature of the ejected particles. The Rosetta/OSIRIS camera sampled the coma phase function of comet 67P, with four series acquired at low phase angles from 2015 January to 2016 May. We also added previously published data to our analysis to increase the temporal resolution of our findings. We measured a BSR in the range ∼ [1.7-3.6], broader than the range found in literature from ground-based observations of other comets. We found that during the post-perihelion phase, the BSR is systematically larger than the classical cometary dust values only for nucleocentric distances smaller than ∼ 100 km. We explain this trend in terms of a cloud of chunks orbiting the nucleus at distances < 100 km ejected during perihelion and slowly collapsing on the nucleus over a few months because of the coma gas drag. This also implies that the threshold particle size for the dust phase function to become similar to the nucleus phase function is between 2.5 mm and 0.1 m, taking into account previous Rosetta findings. © 2018 The Author(s)., The support of the national funding agencies of Germany (DLR: Deutschen Zentrums fur Luft-und Raumfahrt), France (CNES: Centre national d' etudes spatiales), Italy (ASI: Agenzia Spaziale Italiana), Spain (MEC: Ministry of Education& Science), Sweden (SNSB: Swedish National Space Board), and the European Space Agency (ESA) Technical Directorate is gratefully acknowledged.
Published: 2019

135. Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue

Author: Charles Swanton, Thomas B.K. Watkins, Zayd Tippu, Stacey Stanislaw, Nelson Alexander, Lisa L. Gallegos, Carol Jones, Jennifer Thomas, Lars Dyrskjøt, Lavinia Spain, Aoune Barhoumi, Philippe Lamy, Heidi Rosenbaum, Nicolai Juul Birkbak, Hang Xu, Mariam Jamal-Hanjani, Samantha M. Hill, Desiree Schnidrig, Katherine F. Leith, Kevin Litchfield, Iver Nordentoft, Lewis Au, Stephen Hazell, Samra Turajlic, Emilia L. Lim, Daniel Burgess, Stuart Horswell, James Larkin, Alexandre Harlé, and Andrew Rowan
Subjects: medicine.diagnostic_test, Melanoma, Biopsy, medicine, Cancer, Cancer biomarkers, Context (language use), Computational biology, Biology, Lung cancer, medicine.disease, DNA sequencing, Sampling bias
Abstract: While hundreds of thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias is inherent in current methodologies. This is caused by a tissue sample input of fixed dimensions (e.g. 6mm punch) from a single spatial location, which becomes grossly under-powered as tumor volume scales. Indeed our analysis of current clinical and research practice shows that existing protocols sample from only 0.0005% to 2.0% of the total tumor mass, raising the prospect of considerable sampling bias. Failure to address this bias risks undermining the clinical utility of genomic medicine in cancer; through lack of sensitivity to detect actionable mutations, miss-assignment of subclonal variants as clonal, and unreliable estimate of tumor mutational burden (TMB). Here we demonstrate Representative Sequencing (Rep-Seq), as a novel method to achieve unbiased sampling of solid tumor tissue. The Rep-Seq protocol comprises homogenization of all residual tumor material not taken for pathology into a well-mixed solution, coupled with next generation sequencing. Rep-Seq was implemented on a proof of concept basis, and benchmarked against current methods across multiple solid tumor types including renal cell carcinoma, lung cancer, melanoma, breast and colorectal cancer. Analysis of intra-tumor TMB variability showed a high level of misclassification with current single biopsy methods, with 20% of lung tumors, and 52% of bladder tumors, having ≥1 biopsy with high-TMB, but low clonal TMB overall (based on 10.0 mutations/Mb threshold for immune checkpoint inhibitor therapy (CPI)). Misclassification rates by contrast were reduced to 2% (lung) and 4% (bladder) when a more representative sampling frame was used. Clonal clustering analysis revealed rapid convergence of cancer cell fraction estimates in Rep-Seq towards true values, as validated in >60 biopsies, and >5ctDNA samples, taken from a single tumor. As a consequence 100% of variants were correctly classified as clonal by Rep-Seq, compared to ~85% in single biopsy sequencing. In terms of subclonal mutation detection, Rep-Seq achieved a greater sensitivity to detect variants, as compared to single-biopsy sequencing at equivalent depth (p=6.6x10-11). Finally, in a rapid autopsy setting Rep-Seq was able to accurately reconstruct the clonal phylogeny of advanced stage disease, correctly identifying polyclonal metastases, whereas single biopsy sequencing predicted monoclonal disease. Clinically this case showed lack of response to three lines of immune CPI therapy, which was observed in the context of a heterogeneous subclonal neoantigen repertoire. In conclusion, Rep-Seq effectively implements an unbiased tumor sampling approach, drawing DNA molecules from a well-mixed solution of the entire tumor mass, hence removing spatial bias inherent in current approaches. As a result Rep-Seq detects more mutations, achieves greater accuracy in determining clonal from subclonal variants. Rep-Seq offers an improved sampling protocol for tumor profling, with the same equivalent sequencing costs as current methods (single biopsy sequencing), but with significant potential for improved clinical utility.
Published: 2019

136. Diurnal variation of dust and gas production in comet 67P/Churyumov-Gerasimenko at the inbound equinox as seen by OSIRIS and VIRTIS-M on board Rosetta

Author: D. Bodewits, Lyn R. Doose, Giovanna Rinaldi, U. Fink, M. De Cecco, Ivano Bertini, Marco Fulle, Maria Teresa Capria, Anny Chantal Levasseur-Regourd, D. Bockelée-Morvan, Imre Toth, Luisa Lara, Sonia Fornasier, H. Krueger, Mauro Ciarniello, Vladimir E. Zakharov, Holger Sierks, Alessandra Migliorini, Gabriele Arnold, Andrea Longobardo, Carsten Güttler, X. Hu, Michelangelo Formisano, Francesco Marzari, Xian Shi, Wing-Huen Ip, Philippe Lamy, F. La Forgia, Stefano Mottola, Gabriele Cremonese, Detlef Koschny, Zhong-Yi Lin, David Kappel, Raphael Marschall, Fredric W. Taylor, V. Da Deppo, S. Ivanovski, J. J. López-Moreno, Fabrizio Capaccioni, Gianrico Filacchione, H. U. Keller, Stéphane Erard, M. C. De Sanctis, Jean-Loup Bertaux, J. Deller, Pedro J. Gutiérrez, Stefano Debei, R. Rodrigo, Jacques Crovisier, Giampiero Naletto, Björn Davidsson, Cecilia Tubiana, M. A. Barucci, Colin Snodgrass, Monica Lazzarin, Ludmilla Kolokolova, Agenzia Spaziale Italiana, German Research Foundation, Centre National de la Recherche Scientifique (France), Ministerio de Economía y Competitividad (España), Government of Sweden, European Space Agency, l'Observatoire de Paris, Science and Technology Facilities Council (UK), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Istituto Nazionale di Astrofisica (INAF), Institute for Astronomy [Edinburgh] (IfA), University of Edinburgh, Institut für Geodäsie und Geoinformationstechnik, Technische Universität Berlin (TU), International Space Science Institute [Bern] (ISSI), INAF - Osservatorio Astronomico di Trieste (OAT), Dipartimento di Fisica e Astronomia 'Galileo Galilei', Universita degli Studi di Padova, DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Department of Physics [Auburn], Auburn University (AU), INAF - Osservatorio Astronomico di Padova (OAPD), CNR Institute for Photonics and Nanotechnologies (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), Department of Industrial Engineering [Padova], University of Trento [Trento], Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Lunar and Planetary Laboratory [Tucson] (LPL), University of Arizona, Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Institut für Physik und Astrophysik [Potsdam], Universität Potsdam, Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Research and Scientific Support Department, ESTEC (RSSD), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA)-European Space Agency (ESA), Universita degli studi di Napoli 'Parthenope' [Napoli], Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Department of Physics [Oxford], University of Oxford [Oxford], Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Technische Universität Berlin (TUB), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), NASA-California Institute of Technology (CALTECH), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Technische Universität Braunschweig [Braunschweig], and Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)
Subjects: Asteroiden und Kometen, 67P/Churyumov-Gerasimenko, Brightness, 010504 meteorology & atmospheric sciences, Comet, Comets, Data analysis, General, Individual, Methods, FOS: Physical sciences, Coma (optics), Spatial distribution, Atmospheric sciences, 01 natural sciences, 7. Clean energy, Methods: data analysis, individual: 67P/Churyumov-Gerasimenko [Comets], 0103 physical sciences, data analysis [methods], ddc:530, 010303 astronomy & astrophysics, Southern Hemisphere, Comet: individual: 67P/Churyumov-Gerasimenko, 0105 earth and related environmental sciences, Earth and Planetary Astrophysics (astro-ph.EP), [PHYS]Physics [physics], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Diurnal temperature variation, Leitungsbereich PF, comets: individual: 67P/Churyumov-Gerasimenko, Institut für Physik und Astronomie, general [Comets], Astronomy and Astrophysics, Comets: general, 13. Climate action, Space and Planetary Science, astro-ph.EP, Environmental science, Spatial variability, Longitude, Astrophysics - Earth and Planetary Astrophysics
Abstract: Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Open Access funding provided by Max Planck Society., On 27 April 2015, when comet 67P/Churyumov-Gerasimenko was at 1.76 au from the Sun and moving toward perihelion, the OSIRIS and VIRTIS-M instruments on board the Rosetta spacecraft simultaneously observed the evolving dust and gas coma during a complete rotation of the comet.© C. Tubiana et al. 2019, OSIRIS was built by a consortium led by the Max-Planck-Institut fur Sonnensystemforschung, Gottingen, Germany, in collaboration with CISAS, University of Padova, Italy, the Laboratoire d'Astrophysique de Marseille, France, the Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, the Scientific Support Office of the European Space Agency, Noordwijk, The Netherlands, the Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, the Universidad Politechnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut fur Daten-technik und Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged. We thank the Rosetta Science Ground Segment at ESAC, the Rosetta Mission Operations Centre at ESOC and the Rosetta Project at ESTEC for their outstanding work enabling the science return of the Rosetta Mission. VIRTIS was built by a consortium, which includes Italy, France, and Germany, under the scientific responsibility of the Istituto di Astrofisica e Planetologia Spaziali of INAF, Italy, which also guides the scientific operations. The VIRTIS instrument development, led by the prime contractor Leonardo-Finmeccanica (Florence, Italy), has been funded and managed by ASI, with contributions from Observatoire de Meudon financed by CNES, and from DLR. We thank the Rosetta Science Ground Segment and the Rosetta Mission Operations Centre for their support throughout all the phases of the mission. The VIRTIS calibrated data will be available through the ESA's Planetary Science Archive Website (www.rssd.esa.int) and is available upon request until posted to the archive. We thank the following institutions and agencies for support of this work: Italian Space Agency (ASI, Italy) contract number I/024/12/1, Centre National d'Etudes Spatiales (CNES, France), DLR (Germany), NASA (USA) Rosetta Program, and Science and Technology Facilities Council (UK).
Published: 2019

137. Quantitative analysis of isolated boulder fields on comet 67P/Churyumov-Gerasimenko

Author: Philippe Lamy, G. Cremonese, W.-H. Ip, Pamela Cambianica, Marco Fulle, Sabrina Ferrari, Dennis Bodewits, Matteo Massironi, Alice Lucchetti, Frank Scholten, Jean-Loup Bertaux, P. J. Gutierrez, F. La Forgia, Björn Davidsson, Francesco Marzari, Carsten Güttler, Z. Y. Lin, Jakob Deller, Cecilia Tubiana, Ivano Bertini, Detlef Koschny, M. De Cecco, Monica Lazzarin, M. A. Barucci, Holger Sierks, Emanuele Simioni, H. U. Keller, S. Fornasier, R. Rodrigo, Stefano Debei, L. M. Lara, V. Da Deppo, Xian Shi, Stefano Mottola, J.-B. Vincent, Giampiero Naletto, Luca Penasa, Maurizio Pajola, Imre Tóth, J. J. Lopez-Moreno, Cambianica, P. [https://orcid.org/0000-0002-8091-4915], European Space Agency (ESA), Centre National D'Etudes Spatiales (CNES), Agencia Estatal de Investigación (AEI), Deutsches Zentrum für Luft- und Raumfahrt (DLR), Agenzia Spaziale Italiana (ASI), Swedish National Space Agency (SNSA), German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737, Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Universita degli Studi di Padova, INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Dipartimento di Fisica e Astronomia 'Galileo Galilei', CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), Dipartimento di Geoscienze [Padova], Department of Physics [Auburn], Auburn University (AU), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), European Space Research and Technology Centre (ESTEC), Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Industrial Engineering [Padova], University of Trento [Trento], INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), IMPEC - LATMOS, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), NASA-California Institute of Technology (CALTECH), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), and Technische Universität Braunschweig [Braunschweig]
Subjects: 67P/Churyumov-Gerasimenko, 010504 meteorology & atmospheric sciences, Comets, Data analysis, General, Individual, Methods, Population, Comet, Narrow angle, Geometry, Astrophysics, 01 natural sciences, Power law, Fractal, individual: 67P/Churyumov-Gerasimenko [Comets], Power index, 0103 physical sciences, education, data analysis [Methods], 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, [PHYS]Physics [physics], Physics, Comets: individual: 67P/Churyumov-Gerasimenko, education.field_of_study, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], general [Comets], Astronomy and Astrophysics, methods: data analysis, Comets: general, Space and Planetary Science, Spatial ecology, comets: general – comets: individual: 67P/Churyumov-Gerasimenko – methods: data analysis, Sublimation (phase transition), [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract: We provide a detailed quantitative analysis of isolated boulder fields situated in three different regions of comet 67P/Churyumov-Gerasimenko: Imhotep, Hapi, and Hatmehit. This is done to supply a useful method for analyzing the morphology of the boulders and to characterize the regions themselves. Methods. We used OSIRIS Narrow Angle Camera images with a spatial scale smaller than 2 mpx(-1) and analyzed the size-frequency distribution and the cumulative fractional area per boulder population. In addition, we correlated shape parameters, such as circularity and solidity, with both the spatial and the size-frequency distribution of the three populations. Results. We identified 11 811 boulders in the Imhotep, Hapi, and Hatmehit regions. We found that the Hatmehit and Imhotep areas show power indices in the range of -2.3/-2.7. These values could represent a transition between gravitational events caused by thermal weathering and sublimation, and material formed during collapses that has undergone sublimation. The Hapi area is characterized by a lower power index (-1.2/-1.7), suggesting that those boulders have a different origin. They can be the result of material formed during gravitational events and collapses that has undergone continuous fragmentation. We calculated the cumulative fractional area (CFA) in order to investigate how the area is covered by boulders as a function of their sizes. The Hatmehit and Imhotep regions show a CFA that is well fit by a power law. In contrast, the Hapi area does not show the same trend. We analyzed the fractal distributions, finding that the populations seem to be fractal at all dimensions, except for the Hapi distribution, which shows a possible fractal behavior for small dimensions only. Finally, the average values of the shape parameters reveal solid and roundish boulders in all populations we studied.© ESO 2019, OSIRIS was built by a consortium of the Max-Planck Institut fur Sonnensystemforschung, in Guttingen, Germany, CISAS University of Padova, Italy, the Laboratoire de Astrophysique de Marseille, France, the Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, the Research and Scientific Support Department of the European Space Agency, Noordwijk, The Netherlands, the Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, the Universidad Politechnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut fur Datentechnik und Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged. We thank the ESA teams at ESAC, ESOC and ESTEC for their work in support of the Rosetta mission. We made use of Arcgis 10.3.1 software together with the Matlab, Java, and ImageJ software to perform our analysis. I thank Frederic Moisy for sharing the box-count work.
Published: 2019

138. Rosetta/OSIRIS observations of the 67P nucleus during the April 2016 flyby: High-resolution spectrophotometry

Author: H. U. Keller, Alice Lucchetti, M. De Cecco, Giampiero Naletto, D. Bodewits, Monica Lazzarin, Francesco Marzari, R. Rodrigo, P. J. Gutiérrez, Maurizio Pajola, Sonia Fornasier, J. D. P. Deshapriya, Stefano Debei, F. La Forgia, A. Barucci, J. J. López-Moreno, V. Da Deppo, Frank Preusker, Wing-Huen Ip, Philippe Lamy, Matteo Massironi, C. Feller, Holger Sierks, Pedro Hasselmann, Gabriele Cremonese, Björn Davidsson, Cecilia Tubiana, Luisa Lara, B. Gaskell, Carsten Güttler, Frank Scholten, Ivano Bertini, Marco Fulle, Sabrina Ferrari, Xian Shi, Stefano Mottola, Jean-Loup Bertaux, Detlef Koschny, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Universita degli Studi di Padova, Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Dipartimento di Fisica e Astronomia 'Galileo Galilei', CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), International Space Science Institute [Bern] (ISSI), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Research and Scientific Support Department, ESTEC (RSSD), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA)-European Space Agency (ESA), Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Department of Physics [Auburn], Auburn University (AU), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), CNR Institute for Photonics and Nanotechnologies (IFN), Department of Industrial Engineering [Padova], University of Trento [Trento], INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Planetary Science Institute [Tucson] (PSI), Feller, C. [0000-0002-2941-3875], Unidad de Excelencia Científica María de Maeztu Centro de Astrobiología del Instituto Nacional de Técnica Aeroespacial y CSIC, MDM-2017-0737, German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), NASA-California Institute of Technology (CALTECH), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), and Technische Universität Braunschweig [Braunschweig]
Subjects: Asteroiden und Kometen, 67P/Churyumov-Gerasimenko, 010504 meteorology & atmospheric sciences, techniques: image processing, Astrophysics, 01 natural sciences, individual: 67P/Churyumov-Gerasimenko [Comets], Frost line, Spectrophotometry, Spectral slope, Methods, Churyumov–Gerasimenko, image processing [Techniques], space vehicles: instruments, data analysis [Methods], 010303 astronomy & astrophysics, Earth and Planetary Astrophysics (astro-ph.EP), Comets: individual: 67P/Churyumov-Gerasimenko, Physics, [PHYS]Physics [physics], biology, medicine.diagnostic_test, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Resolution (electron density), Comets, Data analysis, Image processing, Individual, Instruments, Space vehicles, Techniques, individual: 67P [Comets], Comet, FOS: Physical sciences, Terrain, Context (language use), instruments [Space vehicles], 0103 physical sciences, medicine, 0105 earth and related environmental sciences, Planetengeodäsie, space vehicles – space vehicles: instruments – comets: individual: 67P/Churyumov–Gerasimenko – techniques: image processing – methods: data analysis, Astronomy and Astrophysics, biology.organism_classification, methods: data analysis, 13. Climate action, Space and Planetary Science, Osiris, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Earth and Planetary Astrophysics
Abstract: From August 2014 to September 2016, the Rosetta spacecraft followed comet 67P/Churyumov-Gerasimenko along its orbit. After the comet passed perihelion, Rosetta performed a flyby manoeuvre over the Imhotep-Khepry transition in April 2016. The OSIRIS/Narrow-Angle-Camera (NAC) acquired 112 observations with mainly three broadband filters (centered at 480, 649, and 743 nm) at a resolution of up to 0.53 m/px and for phase angles between 0.095 degrees and 62 degrees. Aims. We have investigated the morphological and spectrophotometrical properties of this area using the OSIRIS/NAC high-resolution observations. Methods. We assembled the observations into coregistered color cubes. Using a 3D shape model, we produced the illumination conditions and georeference for each observation. We mapped the observations of the transition to investigate its geomorphology. Observations were photometrically corrected using the Lommel-Seeliger disk law. Spectrophotometric analyses were performed on the coregistered color cubes. These data were used to estimate the local phase reddening. Results. The Imhotep-Khepry transition hosts numerous and varied types of terrains and features. We observe an association between a feature's nature, its reflectance, and its spectral slopes. Fine material deposits exhibit an average reflectance and spectral slope, while terrains with diamictons, consolidated material, degraded outcrops, or features such as somber boulders present a lower-than-average reflectance and higher-than-average spectral slope. Bright surfaces present here a spectral behavior consistent with terrains enriched in water-ice. We find a phase-reddening slope of 0.064 +/- 0.001%/100 nm/degrees at 2.7 au outbound, similar to the one obtained at 2.3 au inbound during the February 2015 flyby. Conclusions. Identified as the source region of multiple jets and a host of water-ice material, the Imhotep-Khepry transition appeared in April 2016, close to the frost line, to further harbor several potential locations with exposed water-ice material among its numerous different morphological terrain units.© ESO 2019, OSIRIS was built by a consortium of the Max-Planck-Institut fur Sonnensystemforschung, Gottingen, Germany, CISAS-University of Padova, Italy, Laboratoire d'Astrophysique de Marseille, France, Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, Research and Scientific Support Department of the European Space Agency, Noordwijk, The Netherlands, Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, Universidad Politechnica de Madrid, Spain, Department of Physics and Astronomy of Uppsala University, Sweden, and Institut fur Datentechnik und Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged. Rosetta is an ESA mission with contributions from its member states and NASA. Rosetta's Philae lander is provided by a consortium led by DLR, MPS, CNES, and ASI. The SPICE libraries and PDS resources are developed and maintained by NASA. The authors thank the referee and editors for their questions, remarks, and advices for the improvement of this article.
Published: 2019

139. Spitzer Space Telescope observations of bilobate comet 8P/Tuttle

Author: Olivier Groussin, Hal Weaver, Imre Toth, Michael S. P. Kelley, Laurent Jorda, Philippe Lamy, Yanga R. Fernandez, Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Department of Physics [Orlando] (UCF | Physics), University of Central Florida [Orlando] (UCF), Johns Hopkins University Applied Physics Laboratory [Laurel, MD] (APL), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Rotation period, Physics, Earth and Planetary Astrophysics (astro-ph.EP), 010504 meteorology & atmospheric sciences, Infrared, Comet, Ecliptic, Flux, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Albedo, 01 natural sciences, 7. Clean energy, Spitzer Space Telescope, 13. Climate action, Space and Planetary Science, Geometric albedo, [SDU]Sciences of the Universe [physics], 0103 physical sciences, 010303 astronomy & astrophysics, Astrophysics - Earth and Planetary Astrophysics, 0105 earth and related environmental sciences
Abstract: Comet 8P/Tuttle is a Nearly Isotropic Comet (NIC), whose physical properties are poorly known and could be different from those of Ecliptic Comets (EC) owing to their different origin. Two independent observations have shown that 8P has a bilobate nucleus. Our goal is to determine the physical properties of the nucleus (size, shape, thermal inertia, albedo) and coma (water and dust) of 8P/Tuttle. We observed the inner coma of 8P with the infrared spectrograph (IRS) and the infrared camera (MIPS) of the Spitzer Space Telescope (SST). We obtained one spectrum (5-40 $\mu$m) on 2 November 2007 and a set of 19 images at 24 $\mu$m on 22-23 June 2008 sampling the nucleus rotational period. The data were interpreted using thermal models for the nucleus and the dust coma, and considering 2 possible shape models of the nucleus derived from respectively Hubble Space Telescope visible and Arecibo radar observations. We favor a nucleus shape model composed of 2 contact spheres with respective radii of 2.7+/-0.1 km and 1.1+/-0.1 km and a pole orientation with RA=285+/-12 deg and DEC=+20+/-5 deg. The nucleus has a thermal inertia in the range 0-100 J/K/m^2/s^0.5 and a R-band geometric albedo of 0.042+/-0.008. The water production rate amounts to 1.1+/-0.2x10^28~molecules/s at 1.6 AU from the Sun pre-perihelion, which corresponds to an active fraction of 9%. At the same distance, the $\epsilon f \rho$ quantity amounts to 310+/-34 cm at 1.6~AU, and reaches 325+/-36 cm at 2.2~AU post-perihelion. The dust grain temperature is estimated to 258+/-10 K, which is 37 K larger than the thermal equilibrium temperature at 1.6 AU. This indicates that the dust grains contributing to the thermal infrared flux have a typical size of 10 $\mu$m. The dust spectrum exhibits broad emissions around 10 $\mu$m (1.5-sigma confidence level) and 18 $\mu$m (5-sigma confidence level) that we attribute to amorphous pyroxene., Comment: Accepted by Astronomy & Astrophysics. 14 pages, 11 figures, 6 tables
Published: 2019

140. Linking surface morphology, composition, and activity on the nucleus of 67P/Churyumov-Gerasimenko

Author: Jessica Agarwal, J. Deller, Pedro J. Gutiérrez, R. Rodrigo, Monica Lazzarin, Gabriele Cremonese, Holger Sierks, J. D. P. Deshapriya, Stefano Debei, D. Bodewits, Björn Davidsson, Cecilia Tubiana, Imre Toth, Pedro Hasselmann, Giampiero Naletto, Marco Fulle, Sabrina Ferrari, M. A. Barucci, Sonia Fornasier, Carsten Güttler, J. J. Lopez Moreno, Wing-Huen Ip, Philippe Lamy, Cesare Barbieri, Jean-Loup Bertaux, M. De Cecco, F. La Forgia, M. Küppers, Z. Y. Lin, Maurizio Pajola, M. L. Lara, Ivano Bertini, H. U. Keller, V. Da Deppo, Francesco Marzari, C. Feller, Van H. Hoang, Detlef Koschny, Xian Shi, Stefano Mottola, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institute of Physics [Hanoi], Vietnam Academy of Science and Technology (VAST), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Universita degli Studi di Padova, Dipartimento di Fisica e Astronomia 'Galileo Galilei', CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), Research and Scientific Support Department, ESTEC (RSSD), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA)-European Space Agency (ESA), Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), CNR Institute for Photonics and Nanotechnologies (IFN), Department of Mechanical Engineering [Padova], Department of Industrial Engineering [Padova], Universita degli Studi di Padova-Universita degli Studi di Padova, University of Trento [Trento], Dipartimento di Geoscienze [Padova], INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Space Science [Taiwan], National Central University [Taiwan] (NCU), Institute of Astronomy [Taiwan] (IANCU), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], European Space Astronomy Centre (ESAC), European Space Agency (ESA), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), NASA-California Institute of Technology (CALTECH), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Technische Universität Braunschweig [Braunschweig], ITA, USA, GBR, FRA, DEU, Federal Ministry of Education and Research (Germany), Agence Nationale de la Recherche (France), Agenzia Spaziale Italiana, Ministerio de Ciencia, Innovación y Universidades (España), and Government of Sweden
Subjects: Asteroiden und Kometen, 67P/Churyumov-Gerasimenko, 010504 meteorology & atmospheric sciences, Astrophysics::High Energy Astrophysical Phenomena, Comet, observational [methods], Data analysis, FOS: Physical sciences, Coma (optics), Individual, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Photometric, 01 natural sciences, photometric [techniques], techniques: photometric, individual: 67P/Churyumov-Gerasimenko [Comets], Comet nucleus, 0103 physical sciences, medicine, data analysis [methods], Comets, Methods, 010303 astronomy & astrophysics, Observational, Optical depth, 0105 earth and related environmental sciences, Physics, Comets: individual: 67P/Churyumov-Gerasimenko, Earth and Planetary Astrophysics (astro-ph.EP), [PHYS]Physics [physics], [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Techniques, Resolution (electron density), Astronomy and Astrophysics, methods: data analysis, Plume, medicine.anatomical_structure, 13. Climate action, Space and Planetary Science, comets: individual: 67P/Churyumov-Gerasimenko – methods: data analysis – methods: observational – techniques: photometric, Radiance, Astrophysics::Earth and Planetary Astrophysics, methods: observational, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Nucleus, Astrophysics - Earth and Planetary Astrophysics
Abstract: Open Access article, published by EDP Sciences, under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited., The Rosetta space probe accompanied comet 67P/Churyumov-Gerasimenko for more than two years, obtaining an unprecedented amount of unique data of the comet nucleus and inner coma. This has enabled us to study its activity almost continuously from 4 au inbound to 3.6 au outbound, including the perihelion passage at 1.24 au. This work focuses identifying the source regions of faint jets and outbursts and on studying the spectrophotometric properties of some outbursts. We use observations acquired with the OSIRIS/NAC camera during July-October 2015, that is, close to perihelion. Methods. We analyzed more than 2000 images from NAC color sequences acquired with 7-11 filters covering the 250-1000 nm wavelength range. The OSIRIS images were processed with the OSIRIS standard pipeline up to level 3, that is, converted in radiance factor, then corrected for the illumination conditions. For each color sequence, color cubes were produced by stacking registered and illumination-corrected images. Results. More than 200 jets of different intensities were identified directly on the nucleus. Some of the more intense outbursts appear spectrally bluer than the comet dark terrain in the visible-to-near-infrared region. We attribute this spectral behavior to icy grains mixed with the ejected dust. Some of the jets have an extremely short lifetime. They appear on the cometary surface during the color sequence observations, and vanish in less than some few minutes after reaching their peak. We also report a resolved dust plume observed in May 2016 at a resolution of 55 cm pixel(-1), which allowed us to estimate an optical depth of similar to 0.65 and an ejected mass of similar to 2200 kg, assuming a grain bulk density of similar to 800 kg m(-3). We present the results on the location, duration, and colors of active sources on the nucleus of 67P from the medium-resolution (i.e., 6-10 m pixel(-1)) images acquired close to perihelion passage. The observed jets are mainly located close to boundaries between different morphological regions. Some of these active areas were observed and investigated at higher resolution (up to a few decimeter per pixel) during the last months of operations of the Rosetta mission. Conclusions. These observations allow us to investigate the link between morphology, composition, and activity of cometary nuclei. Jets depart not only from cliffs, but also from smooth and dust-covered areas, from fractures, pits, or cavities that cast shadows and favor the recondensation of volatiles. This study shows that faint jets or outbursts continuously contribute to the cometary activity close to perihelion passage, and that these events are triggered by illumination conditions. Faint jets or outbursts are not associated with a particular terrain type or morphology.© S. Fornasier et al. 2019, OSIRIS was built by a consortium led by the Max-Planck-Institut fur Sonnensystemforschung, Goettingen, Germany, in collaboration with CISAS, University of Padova, Italy, the Laboratoire d'Astrophysique de Marseille, France, the Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, the Scientific Support Office of the European Space Agency, Noordwijk, the Netherlands, the Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, the Universidad Politechnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut fur Datentechnik und Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged. We thank the Rosetta Science Ground Segment at ESAC, the Rosetta Mission Operations Centre at ESOC and the Rosetta Project at ESTEC for their outstanding work enabling the science return of the Rosetta Mission. S.F. acknowledges the financial support from the France Agence Nationale de la Recherche (programme Classy, ANR-17-CE31-0004). The authors thank H. Campins for his comments that helped us improve this article. The authors would like to thank Andrew Cooper and Marco Parigi for spotting the inconsistencies in regional boundaried of Fig. 1 in the online preprint version of the paper.
Published: 2019

141. Near-Sun observations of an F-corona decrease and K-corona fine structure

Author: A. K. Higginson, Alexis P. Rouillard, Paulette C. Liewer, Robin C. Colaninno, Dennis G. Socker, Philippe Lamy, Jon A. Linker, N. Rich, B. Gallagher, Volker Bothmer, Mark G. Linton, Russell A. Howard, Athanasios Kouloumvakos, Pierre Rochus, N.-E. Raouafi, Clarence M. Korendyke, Nicolas Poirier, A. Thernisien, Craig DeForest, Guillermo Stenborg, Paulo Penteado, Jeffrey R. Hall, Nicholeen M. Viall, Angelos Vourlidas, Phillip Hess, and Simon Plunkett
Subjects: Physics, Multidisciplinary, Zodiacal light, 010504 meteorology & atmospheric sciences, Scattering, Astronomical unit, Astrophysics, Electron, Solar physics, 01 natural sciences, Corona, Instability, Current sheet, 13. Climate action, Physics::Space Physics, 0103 physical sciences, Astrophysics::Solar and Stellar Astrophysics, Astrophysics::Earth and Planetary Astrophysics, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences
Abstract: Remote observations of the solar photospheric light scattered by electrons (the K-corona) and dust (the F-corona or zodiacal light) have been made from the ground during eclipses1 and from space at distances as small as 0.3 astronomical units2–5 to the Sun. Previous observations6–8 of dust scattering have not confirmed the existence of the theoretically predicted dust-free zone near the Sun9–11. The transient nature of the corona has been well characterized for large events, but questions still remain (for example, about the initiation of the corona12 and the production of solar energetic particles13) and for small events even its structure is uncertain14. Here we report imaging of the solar corona15 during the first two perihelion passes (0.16–0.25 astronomical units) of the Parker Solar Probe spacecraft13, each lasting ten days. The view from these distances is qualitatively similar to the historical views from ground and space, but there are some notable differences. At short elongations, we observe a decrease in the intensity of the F-coronal intensity, which is suggestive of the long-sought dust free zone9–11. We also resolve the fine-scale plasma structure of very small eruptions, which are frequently ejected from the Sun. These take two forms: the frequently observed magnetic flux ropes12,16 and the predicted, but not yet observed, magnetic islands17,18 arising from the tearing-mode instability in the current sheet. Our observations of the coronal streamer evolution confirm the large-scale topology of the solar corona, but also reveal that, as recently predicted19, streamers are composed of yet smaller substreamers channelling continual density fluctuations at all visible scales. Observations of the solar corona by the Parker Solar Probe reveal evidence for the predicted dust-free zone and confirm that streamers comprise smaller substreamers that channel continuous multiscale density fluctuations.
Published: 2019
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142. (16) Psyche: A mesosiderite-like asteroid?

Author: Tadeusz Michalowski, P. Bartczak, J. Grice, Brian D. Warner, Christophe Dumas, Frédéric Vachier, Laurent Jorda, Josef Hanus, Olivier Witasse, Alexis Drouard, E. Podlewska-Gaca, Fabrice Cipriani, Romain Fétick, François Colas, Julie Castillo-Rogez, Philippe Lamy, F. Marchis, Marin Ferrais, Emmanuel Jehin, Jérôme Berthier, Josef Ďurech, P. Michel, A. Marciniak, Arthur Vigan, Pierre Vernazza, H. Le Coroller, Thierry Fusco, Bin Yang, Michael Marsset, Mirel Birlan, Toni Santana-Ros, Benoit Carry, Matti Viikinkoski, Agnieszka Kryszczyńska, Mikko Kaasalainen, K. Tazhenova, M. Pajuelo, Paolo Tanga, Tampere University of Technology [Tampere] (TUT), Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Astronomical Institute of Charles University, Charles University [Prague] (CU), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Astrophysics Research Centre [Belfast] (ARC), Queen's University [Belfast] (QUB), Search for Extraterrestrial Intelligence Institute (SETI), DOTA, ONERA, Université Paris Saclay (COmUE) [Châtillon], ONERA-Université Paris Saclay (COmUE), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Faculty of Physics [Poznań], Adam Mickiewicz University in Poznań (UAM), TMT International Observatory, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), Institut d'Astrophysique et de Géophysique [Liège], Université de Liège, Open University (School of Physical Sciences), Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Pontificia Universidad Católica del Perú = Pontifical Catholic University of Peru (PUCP), University of Szczecin, Center for Solar System Studies (CS3), European Southern Observatory [Santiago] (ESO), European Southern Observatory (ESO), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), TMT Observatory, European Space Agency (ESA), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), and Pontificia Universidad Católica del Perú (PUCP)
Subjects: Physics, Earth and Planetary Astrophysics (astro-ph.EP), 010504 meteorology & atmospheric sciences, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Spectral properties, FOS: Physical sciences, Astronomy and Astrophysics, Context (language use), Astrophysics, 01 natural sciences, Parent body, Psyche, Mesosiderite, Meteorite, Space and Planetary Science, Asteroid, [SDU]Sciences of the Universe [physics], 0103 physical sciences, Hill sphere, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Astrophysics - Earth and Planetary Astrophysics
Abstract: Asteroid (16) Psyche is the target of the NASA Psyche mission. It is considered one of the few main-belt bodies that could be an exposed proto-planetary metallic core and that would thus be related to iron meteorites. Such an association is however challenged by both its near- and mid-infrared spectral properties and the reported estimates of its density. Here, we aim to refine the density of (16) Psyche to set further constraints on its bulk composition and determine its potential meteoritic analog. We observed (16) Psyche with ESO VLT/SPHERE/ZIMPOL as part of our large program (ID 199.C-0074). We used the high angular resolution of these observations to refine Psyche's three-dimensional (3D) shape model and subsequently its density when combined with the most recent mass estimates. In addition, we searched for potential companions around the asteroid. We derived a bulk density of 3.99\,$\pm$\,0.26\,g$\cdot$cm$^{-3}$ for Psyche. While such density is incompatible at the 3-sigma level with any iron meteorites ($\sim$7.8\,g$\cdot$cm$^{-3}$), it appears fully consistent with that of stony-iron meteorites such as mesosiderites (density $\sim$4.25\,$\cdot$cm$^{-3}$). In addition, we found no satellite in our images and set an upper limit on the diameter of any non-detected satellite of 1460\,$\pm$\,200}\,m at 150\,km from Psyche (0.2\%\,$\times$\,R$_{Hill}$, the Hill radius) and 800\,$\pm$\,200\,m at 2,000\,km (3\%\,$\times$\,$R_{Hill}$). Considering that the visible and near-infrared spectral properties of mesosiderites are similar to those of Psyche, there is merit to a long-published initial hypothesis that Psyche could be a plausible candidate parent body for mesosiderites., 16 pages
Published: 2018

143. Periodic behaviour of coronal mass ejections, eruptive events, and solar activity proxies during solar cycles 23 and 24

Author: Brice Boclet, Imre Tóth, Philippe Lamy, Tatiana Barlyaeva, Julien Wojak, Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), HELIOS - LATMOS, Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Atmospheric Science, 010504 meteorology & atmospheric sciences, Solar cycle 23, FOS: Physical sciences, Astrophysics, Atmospheric sciences, 01 natural sciences, Solar prominence, Physics - Space Physics, 0103 physical sciences, Coronal mass ejection, 010303 astronomy & astrophysics, Southern Hemisphere, Solar and Stellar Astrophysics (astro-ph.SR), 0105 earth and related environmental sciences, Sunspot, Solar flare, integumentary system, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], Northern Hemisphere, Space Physics (physics.space-ph), Solar cycle, Geophysics, Astrophysics - Solar and Stellar Astrophysics, 13. Climate action, Space and Planetary Science, Physics - Data Analysis, Statistics and Probability, Geology, Data Analysis, Statistics and Probability (physics.data-an)
Abstract: We report on the parallel analysis of the periodic behaviour of coronal mass ejections (CMEs) based on 21 years [1996 -- 2016] of observations with the SOHO/LASCO--C2 coronagraph, solar flares, prominences, and several proxies of solar activity. We consider values of the rates globally and whenever possible, distinguish solar hemispheres and solar cycles 23 and 24. Periodicities are investigated using both frequency (periodogram) and time-frequency (wavelet) analysis. We find that these different processes, in addition to following the $\approx$11-year Solar Cycle, exhibit diverse statistically significant oscillations with properties common to all solar, coronal, and heliospheric processes: variable periodicity, intermittence, asymmetric development in the northern and southern solar hemispheres, and largest amplitudes during the maximum phase of solar cycles, being more pronounced during solar cycle 23 than the weaker cycle 24. However, our analysis reveals an extremely complex and diverse situation. For instance, there exists very limited commonality for periods of less than one year. The few exceptions are the periods of 3.1--3.2 months found in the global occurrence rates of CMEs and in the sunspot area (SSA) and those of 5.9--6.1 months found in the northern hemisphere. Mid-range periods of $\approx$1 and $\approx$2 years are more wide spread among the studied processes, but exhibit a very distinct behaviour with the first one being present only in the northern hemisphere and the second one only in the southern hemisphere. These periodic behaviours likely results from the complexity of the underlying physical processes, prominently the emergence of magnetic flux., Comment: 33 pages, 15 figures, 2 tables
Published: 2018

144. A Beta-Mixture Model for Dimensionality Reduction, Sample Classification and Analysis.

Author: Kirsti Laurila, Bodil Oster, Claus L. Andersen, Philippe Lamy, Torben F. ørntoft, Olli Yli-Harja, and Carsten Wiuf
Published: 2011
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145. Spatial and temporal clonal evolution during development of metastatic urothelial carcinoma

Author: Michael Borre, Lars Dyrskjøt, Philippe Lamy, Iver Nordentoft, Søren Høyer, Torben F. Ørntoft, Mathilde Borg Houlberg Thomsen, Søren Vang, Jørgen Bjerggaard Jensen, and Jakob Hedegaard
Subjects: 0301 basic medicine, Cancer Research, Pathology, medicine.medical_specialty, Time Factors, Metastatic Urothelial Carcinoma, Tumour heterogeneity, medicine.medical_treatment, Biology, Models, Biological, Somatic evolution in cancer, Metastasis, Targeted therapy, Clonal Evolution, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Genetics, medicine, Humans, APOBEC Deaminases, Neoplasm Metastasis, Phylogeny, Research Articles, Exome sequencing, Bladder cancer, Sequence Analysis, DNA, General Medicine, medicine.disease, 030104 developmental biology, Urinary Bladder Neoplasms, Oncology, Mutagenesis, 030220 oncology & carcinogenesis, Mutation, Cancer cell, Disease Progression, Cancer research, Molecular Medicine, Urothelium
Abstract: Patients with metastatic bladder cancer have a median survival of only 13-14 months. Precision medicine using targeted therapy may improve survival. Here we investigated spatial and temporal tumour evolution and tumour heterogeneity in order to evaluate the potential use of targeted treatment of metastatic bladder cancer. We performed a proof-of-concept study by whole exome sequencing of multiple tumour regions (n = 22) from three patients with metastatic bladder cancer. DNA from primary and metastatic tumour biopsies was analysed for mutations using Mutect and potential therapeutic targets were identified. We identified 256, 265 and 378 somatic mutations per patient, encompassing mutations with an estimated functional impact in 6-12 known disease driver genes per patient. Disease driver mutations present in all tumour regions could be identified in all cases, however, over time metastasis specific driver mutations emerged. For each patient we identified 6-10 potentially therapeutic targets, however very few targets were present in all regions. Low mutational allele frequencies were observed in most regions suggesting a complex mixture of different cancer cells with no spatial demarcation of subclones. In conclusion, primary bladder tumours and metastatic lesions showed heterogeneity at the molecular level, but within the primary tumour the heterogeneity appeared low. The observed lack of potential therapeutic targets common to all cancer cells in primary tumours and metastases emphasizes the challenges in designing rational targeted therapy solely based on analysis of the primary tumours.
Published: 2016

146. Meter-scale thermal contraction crack polygons on the nucleus of comet 67P/Churyumov-Gerasimenko

Author: Cesare Barbieri, Jessica Agarwal, Monica Lazzarin, Ekkehard Kührt, J. J. Lopez Moreno, Pedro J. Gutiérrez, M. A. Barucci, Detlef Koschny, Björn Davidsson, Nicolas Thomas, Claire Capanna, Cecilia Tubiana, J.-R. Kramm, Simone Marchi, Michael Küppers, Harald Michalik, Antoine Pommerol, Antoine Séjourné, Marco Fulle, Matteo Massironi, Philippe Lamy, M. F. A'Hearn, Nilda Oklay, Robert Gaskell, Stubbe F. Hviid, S. Höfner, Francesco Marzari, Mohamed Ramy El-Maarry, Olivier Groussin, Sylvain Bouley, Sonia Fornasier, Holger Sierks, Stefano Debei, Jean-Loup Bertaux, L. Sabau, K. P. Wenzel, Hans Rickman, Giampiero Naletto, V. Da Deppo, Ivano Bertini, J. B. Vincent, Gabriele Cremonese, Rafael Rodrigo, Luisa Lara, M. De Cecco, Wing-Huen Ip, Laurent Jorda, A.-T. Auger, J. Knollenberg, H. U. Keller, Carsten Güttler, Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Géosciences Paris Sud (GEOPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU), Physikalisches Institut [Bern], Universität Bern [Bern] (UNIBE), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Planetary Science Institute [Tucson] (PSI), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Solar System Exploration Research Virtual Institute (SSERVI), Southwest Research Institute [Boulder] (SwRI), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, Dipartimento di Fisica e Astronomia 'Galileo Galilei', Università degli Studi di Padova = University of Padua (Unipd), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), Space Research Centre of Polish Academy of Sciences (CBK), Polska Akademia Nauk = Polish Academy of Sciences (PAN), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Department of Industrial Engineering [Padova], Laboratory for Ultraviolet and X-ray Optical Research [Padova] (LUXOR), CNR Institute for Photonics and Nanotechnologies (IFN), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR)-National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), University of Trento [Trento], INAF - Osservatorio Astronomico di Trieste (OAT), Istituto Nazionale di Astrofisica (INAF), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Institute of Space Science [Taiwan], National Central University [Taiwan] (NCU), European Space Astronomy Centre (ESAC), INAF - Osservatorio Astronomico di Padova (OAPD), Institut für Datentechnik und Kommunikationsnetze, Department of Information Engineering [Padova] (DEI), Instituto Nacional de Técnica Aeroespacial (INTA), Research and Scientific Support Department, ESTEC (RSSD), Agence Spatiale Européenne = European Space Agency (ESA)-Agence Spatiale Européenne = European Space Agency (ESA), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Universität Bern [Bern], PSL Research University (PSL)-PSL Research University (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Sonnensystemforschung (MPS), Universita degli Studi di Padova, Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), European Space Agency (ESA), Polska Akademia Nauk (PAN), Technische Universität Braunschweig [Braunschweig], PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, Consiglio Nazionale delle Ricerche [Roma] (CNR)-Consiglio Nazionale delle Ricerche [Roma] (CNR), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), European Space Agency (ESA)-European Space Agency (ESA), German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, ITA, USA, GBR, FRA, DEU, and Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA)
Subjects: Solar System, 010504 meteorology & atmospheric sciences, Comet, [SDU.ASTR.EP]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Earth and Planetary Astrophysics [astro-ph.EP], Geometry, Trough (economics), 01 natural sciences, Nucleus, Latitude, Jupiter, Comets, Geological processes, 0103 physical sciences, Thermal, Thermal analysis, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Remote sensing, Astronomy and Astrophysics, Space and Planetary Science, [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], 520 Astronomy, Atmospheric temperature range, 620 Engineering, Geology
Abstract: We report on the detection and characterization of more than 6300 polygons on the surface of the nucleus of comet 67P/Churyumov-Gerasimenko, using images acquired by the OSIRIS camera onboard Rosetta between August 2014 and March 2015. They are found in consolidated terrains and grouped in localized networks. They are present at all latitudes (from North to South) and longitudes (head, neck, and body), sometimes on pit walls or following lineaments. About 1.5% of the observed surface is covered by polygons. Polygons have an homogeneous size across the nucleus, with 90% of them in the size range 1 – 5 m and a mean size of 3.0 ± 1.4 m. They show different morphologies, depending on the width and depth of their trough. They are found in networks with 3- or 4-crack intersection nodes. The polygons observed on 67P are consistent with thermal contraction crack polygons formed by the diurnal or seasonal temperature variations in a hard (MPa) and consolidated sintered layer of water ice, located a few centimeters below the surface. Our thermal analysis shows an evolution of thermal contraction crack polygons according to the local thermal environment, with more evolved polygons (i.e. deeper and larger troughs) where the temperature and the diurnal and seasonal temperature range are the highest. Thermal contraction crack polygons are young surface morphologies that probably formed after the injection of 67P in the inner solar system, typically 100,000 years ago, and could be as young as a few orbital periods, following the decreasing of its perihelion distance in 1959 from 2.7 to 1.3 a.u. Meter scale thermal contraction crack polygons should be common features on the nucleus of Jupiter family comets.© 2017 Elsevier Inc., OSIRIS was built by a consortium of the Max-Planck-Institut fur Sonnensystemforschung, Gottingen, Germany, CISAS-University of Padova, Italy, the Laboratoire d'Astrophysique de Marseille, France, the Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, the Research and Scientific Support Department of the European Space Agency, Noordwijk, The Netherlands, the Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, the Universidad Politechnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut fur Datentechnik and Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged.
Published: 2018

147. The big lobe of 67P/Churyumov–Gerasimenko comet: morphological and spectrophotometric evidences of layering as from OSIRIS data

Author: P. J. Gutierrez, Xian Shi, Carsten Güttler, Pedro Hasselmann, J. J. López-Moreno, Matteo Massironi, Monica Lazzarin, Detlef Koschny, Stubbe F. Hviid, M. A. Barucci, Björn Davidsson, Cecilia Tubiana, Ivano Bertini, Pamela Cambianica, Nicolas Thomas, Michael Küppers, Francesca Ferri, Luca Penasa, Francesco Marzari, M. De Cecco, W-H. Ip, J. L. Bertaux, Marco Franceschi, Laurent Jorda, Holger Sierks, J.-B. Vincent, Olivier Groussin, E. Frattin, F. La Forgia, Stefano Debei, Philippe Lamy, Jakob Deller, Maurizio Pajola, Nilda Oklay, Giampiero Naletto, Ekkehard Kührt, Sonia Fornasier, L. M. Lara, V. Da Deppo, Marco Fulle, Jörg Knollenberg, Emanuele Simioni, Sabrina Ferrari, R. Rodrigo, Gabriele Cremonese, Alice Lucchetti, H. U. Keller, Dennis Bodewits, Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Universita degli Studi di Padova, Dipartimento di Fisica e Astronomia 'Galileo Galilei', CNR Istituto di Fotonica e Nanotecnologie [Padova] (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Research and Scientific Support Department, ESTEC (RSSD), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA)-European Space Agency (ESA), Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Fundacion Galileo Galilei, Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, CNR Institute for Photonics and Nanotechnologies (IFN), Department of Industrial Engineering [Padova], Dipartimento di Geoscienze [Padova], INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Operations Department (ESAC), European Space Astronomy Centre (ESAC), Physikalisches Institut [Bern], Universität Bern [Bern], Center for Space and Habitability (CSH), University of Bern, German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Ferrari, Sabrina, Penasa, L., La Forgia, F., Massironi, M., Naletto, G., Lazzarin, M., Fornasier, S., Hasselmann, P. H., Lucchetti, A., Pajola, M., Ferri, F., Cambianica, Pamela, Oklay, N., Tubiana, C., Sierks, H., Lamy, P. L., Rodrigo, R., Koschny, D., Davidsson, B., Barucci, M. A., Bertaux, J. -L., Bertini, I., Bodewits, D., Cremonese, G., Da Deppo, V., Debei, S., De Cecco, M., Deller, J., Franceschi, M., Frattin, Elisa, Fulle, M., Groussin, O., Gutiérrez, P. J., Güttler, C., Hviid, S. F., Ip, W. -H., Jorda, L., Keller, H. U., Knollenberg, J., Kührt, E., Küppers, M., Lara, L. M., López-Moreno, J. J., Marzari, F., Shi, X., Simioni, E., Thomas, N., Vincent, J. -B., Università degli Studi di Padova = University of Padua (Unipd), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Agence Spatiale Européenne = European Space Agency (ESA)-Agence Spatiale Européenne = European Space Agency (ESA), NASA-California Institute of Technology (CALTECH), Universität Bern [Bern] (UNIBE), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), and Technische Universität Braunschweig [Braunschweig]
Subjects: 67P/Churyumov-Gerasimenko, Brightness, Comets: general, Comets: individual: 67P/Churyumov-Gerasimenko, Methods: data analysis, Techniques: image processing, Astronomy and Astrophysics, Space and Planetary Science, 010504 meteorology & atmospheric sciences, Multispectral image, Comet, Data analysis, Mineralogy, Spatial distribution, 01 natural sciences, Texture (geology), Image processing, individual: 67P/Churyumov-Gerasimenko [Comets], 0103 physical sciences, medicine, Comets, image processing [Techniques], spectral variegation, 010303 astronomy & astrophysics, 0105 earth and related environmental sciences, Physics, [PHYS]Physics [physics], biology, OSIRIS cameras, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], 520 Astronomy, general [Comets], Astronomy and Astrophysic, biology.organism_classification, 620 Engineering, Lobe, data analysi [Methods], medicine.anatomical_structure, multiple-filters, Variegation (histology), Osiris
Abstract: Between 2014 and 2016, ESA's Rosetta OSIRIS cameras acquired multiple-filters images of the layered nucleus of comet 67P/Churyumov-Gerasimenko, ranging from ultraviolet to near-infrared wavelengths. No correlation between layers disposition and surface spectral variegation has been observed so far. This paper investigates possible spectral differences among decametre-thickness outcropping layers of the biggest lobe of the comet by means of OSIRIS image dataset. A two-classes maximum likelihood classification was applied on consolidated outcrops and relative deposits identified on post-perihelion multispectral images of the big lobe. We distinguished multispectral data on the basis of the structural elevation of the onion-shell Ellipsoidal Model of 67P. The spatial distribution of the two classes displays a clear dependence on the structural elevation, with the innermost class resulting over 50 per cent brighter than the outermost one. Consolidated cometarymaterials located at different structural levels are characterized by different brightness and revealed due to the selective removal of large volumes. This variegation can be attributed to a different texture of the outcrop surface and/or to a different content of refractory materials.© 2018 The Author(s) Published by Oxford University Press on behalf of the Royal Astronomical Society., We are grateful to Paul Helfenstein for corrections that improved our paper. OSIRIS was built by a consortium of the Max-Planck-Institut fur Sonnensystemforschung, in Goottingen, Germany, CISAS-University of Padova, Italy, the Laboratoire d'Astrophysique de Marseille, France, the Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, the Research and Scientific Support Department of the European Space Agency, Noordwijk, The Netherlands, the Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, the Universidad Politechnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut fur Datentechnik und Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), Italy (ASI), France (CNES), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged. We thank the ESA teams at ESAC, ESOC, and ESTEC for their work in support of the Rosetta mission.
Published: 2018

148. Coma morphology of comet 67P controlled by insolation over irregular nucleus

Author: Nilda Oklay, Jessica Agarwal, V. Da Deppo, M. De Cecco, Philippe Lamy, J.-B. Vincent, Laurent Jorda, G. Cremonese, X. Hu, Steve Boudreault, Carsten Güttler, M. A. Barucci, W-H. Ip, Marco Fulle, M. Rose, Imre Toth, Stefano Debei, Detlef Koschny, Sonia Fornasier, Ekkehard Kührt, Cesare Barbieri, L. M. Lara, Jakob Deller, P. J. Gutierrez, Francesco Marzari, Holger Sierks, Xian Shi, Jörg Knollenberg, Stefano Mottola, Maurizio Pajola, Géza Kovács, R. Rodrigo, Giampiero Naletto, J. J. López-Moreno, Olivier Groussin, J.-R. Kramm, Jean-Loup Bertaux, Dennis Bodewits, H. U. Keller, Ivano Bertini, Michael Küppers, Stubbe F. Hviid, Björn Davidsson, Cecilia Tubiana, Monica Lazzarin, Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Max-Planck-Gesellschaft, DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], PI-DSMC software package, INAF - Osservatorio Astronomico di Trieste (OAT), Istituto Nazionale di Astrofisica (INAF), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), NASA Ames Research Center (ARC), Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Dipartimento di Fisica e Astronomia 'Galileo Galilei', Università degli Studi di Padova = University of Padua (Unipd), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), European Space Research and Technology Centre (ESTEC), Agence Spatiale Européenne = European Space Agency (ESA), CNR Institute for Photonics and Nanotechnologies (IFN), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Department of Industrial Engineering [Padova], University of Trento [Trento], Laboratoire d'Astrophysique de Marseille (LAM), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Astronomy [Taiwan] (IANCU), National Central University [Taiwan] (NCU), European Space Astronomy Centre (ESAC), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Dipartimento di Fisica [Politecnico Milano] (POLIMI), Politecnico di Milano [Milan] (POLIMI), Konkoly Observatory, Research Centre for Astronomy and Earth Sciences [Budapest], Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Agencia Estatal de Investigación (España), European Space Agency, Swedish National Space Agency, Max-Planck-Institut für Sonnensystemforschung (MPS), Universita degli Studi di Padova, Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), European Space Agency (ESA), Consiglio Nazionale delle Ricerche [Roma] (CNR), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Dipartimento di Fisica [Politecnico Milano], Technische Universität Braunschweig [Braunschweig], PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), and Dipartimento di Fisica [Milano]
Subjects: Brightness, 010504 meteorology & atmospheric sciences, Comet, structural complexity, Coma (optics), Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, cometary comae, dust jets, 0103 physical sciences, Rosetta, medicine, Sunrise, surface, Surface layer, 010303 astronomy & astrophysics, Astrophysics::Galaxy Astrophysics, 0105 earth and related environmental sciences, Physics, Spacecraft, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], business.industry, Astronomy and Astrophysics, dust coma, Outgassing, medicine.anatomical_structure, 13. Climate action, Astrophysics::Earth and Planetary Astrophysics, business, Nucleus, Comet 67/P
Abstract: While the structural complexity of cometary comae is already recognizable from telescopic observations, the innermost region, within a few radii of the nucleus, was not resolved until spacecraft exploration became a reality. The dust coma displays jet-like features of enhanced brightness superposed on a diffuse background . Some features can be traced to specific areas on the nucleus, and result conceivably from locally enhanced outgassing and/or dust emission. However, diffuse or even uniform activity over topographic concavity can converge to produce jet-like features. Therefore, linking observed coma morphology to the distribution of activity on the nucleus is difficult. Here, we study the emergence of dust activity at sunrise on comet 67P/Churyumov-Gerasimenko using high-resolution, stereo images from the OSIRIS camera onboard the Rosetta spacecraft, where the sources and formation of the jet-like features are resolved. We perform numerical simulations to show that the ambient dust coma is driven by pervasive but non-uniform water outgassing from the homogeneous surface layer. Physical collimations of gas and dust flows occur at local maxima of insolation and also via topographic focusing. Coma structures are projected to exhibit jet-like features that vary with the perspective of the observer. For an irregular comet such as 67P/Churyumov-Gerasimenko, near-nucleus coma structures can be concealed in the shadow of the nucleus, which further complicates the picture.© 2018 The Author(s)., OSIRIS was built by a consortium led by the Max-Planck-Institut fur Sonnensystemforschung, Gottingen, Germany, in collaboration with CISAS, University of Padova, Italy, the Laboratoire d'Astrophysique de Marseille, France, the Instituto de Astrofisica de Andalucia, CSIC, Granada, Spain, the Scientific Support Office of the European Space Agency, Noordwijk, The Netherlands, the Instituto Nacional de Tecnica Aeroespacial, Madrid, Spain, the Universidad Politechnica de Madrid, Spain, the Department of Physics and Astronomy of Uppsala University, Sweden, and the Institut fur Datentechnik und Kommunikationsnetze der Technischen Universitat Braunschweig, Germany. The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB) and the ESA Technical Directorate is gratefully acknowledged.
Published: 2018

149. The phase function and density of the dust observed at comet 67P/Churyumov-Gerasimenko

Author: P. J. Gutierrez, W-H. Ip, F. Moreno, Monica Lazzarin, F. La Forgia, Ivano Bertini, Xian Shi, V. Da Deppo, Cesare Barbieri, Stefano Mottola, Holger Sierks, Giampiero Naletto, Pasquale Palumbo, M. A. Barucci, Jakob Deller, Stavro Ivanovski, H. S. Hviid, J. Lasue, Giovanna Rinaldi, Marco Fulle, Michael Küppers, Philippe Lamy, Hans Rickman, Stefano Debei, Ekkehard Kührt, Alessandra Rotundi, Detlef Koschny, Nicolas Thomas, R. Rodrigo, M. De Cecco, J.-R. Kramm, Björn Davidsson, Cecilia Tubiana, Laurent Jorda, G. Cremonese, Carsten Güttler, J. L. Bertaux, Anny Chantal Levasseur-Regourd, M. L. Lara, Olivier Groussin, Sonia Fornasier, Jörg Knollenberg, V. Della Corte, J. J. López-Moreno, H. U. Keller, Francesco Marzari, Dennis Bodewits, Agenzia Spaziale Italiana, INAF - Osservatorio Astronomico di Trieste (OAT), Istituto Nazionale di Astrofisica (INAF), Helmholtz zentrum für Schwerionenforschung GmbH (GSI), Dipartimento di Fisica e Astronomia 'Galileo Galilei', Universita degli Studi di Padova, Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Dipartimento di Scienze e Tecnologie [Napoli] (DIST), Universita degli studi di Napoli 'Parthenope' [Napoli], Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Department of Physics and Astronomy [Uppsala], Uppsala University, Space Research Centre of Polish Academy of Sciences (CBK), Polska Akademia Nauk = Polish Academy of Sciences (PAN), Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, INAF - Osservatorio Astronomico di Padova (OAPD), Laboratory for Ultraviolet and X-ray Optical Research [Padova] (LUXOR), CNR Institute for Photonics and Nanotechnologies (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR)-Consiglio Nazionale delle Ricerche [Roma] (CNR), Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Department of Industrial Engineering [Padova], University of Trento [Trento], Institute of Space Science [Taiwan], National Central University [Taiwan] (NCU), Space Science Institute [Macau] (SSI), Macau University of Science and Technology (MUST), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], European Space Astronomy Centre (ESAC), Physikalisches Institut [Bern], Universität Bern [Bern], Università degli Studi di Padova = University of Padua (Unipd), Università degli Studi di Napoli 'Parthenope' = University of Naples (PARTHENOPE), Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Agence Spatiale Européenne = European Space Agency (ESA), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR)-National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), NASA-California Institute of Technology (CALTECH), Universität Bern [Bern] (UNIBE), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Polska Akademia Nauk (PAN), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Technische Universität Braunschweig [Braunschweig], INAF - Osservatorio Astronomico di Trieste ( OAT ), Istituto Nazionale di Astrofisica ( INAF ), Istituto di Astrofisica e Planetologia Spaziali ( IAPS ), Dipartimento di Scienze e Tecnologie [Napoli] ( DIST ), Max-Planck-Institut für Sonnensystemforschung ( MPS ), Institut de recherche en astrophysique et planétologie ( IRAP ), Université Paul Sabatier - Toulouse 3 ( UPS ) -Observatoire Midi-Pyrénées ( OMP ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Atmosphères, Milieux, Observations Spatiales ( LATMOS ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Instituto de Astrofísica de Andalucía ( IAA ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), Deutsches Zentrum für Luft- und Raumfahrt [Berlin] ( DLR ), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' ( CISAS ), Laboratoire d'Astrophysique de Marseille ( LAM ), Aix Marseille Université ( AMU ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National d'Etudes Spatiales ( CNES ) -Centre National de la Recherche Scientifique ( CNRS ), Centro de Astrobiologia [Madrid] ( CAB ), Instituto Nacional de Técnica Aeroespacial ( INTA ) -Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), International Space Science Institute ( ISSI ), European Space Research and Technology Centre ( ESTEC ), European Space Agency ( ESA ), Space Research Centre [Warsaw] ( CBK ), Polska Akademia Nauk ( PAN ), Laboratoire d'études spatiales et d'instrumentation en astrophysique ( LESIA ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), INAF - Osservatorio Astronomico di Padova ( OAPD ), Laboratory for Ultraviolet and X-ray Optical Research [Padova] ( LUXOR ), CNR Institute for Photonics and Nanotechnologies ( IFN ), Consiglio Nazionale delle Ricerche [Roma] ( CNR ) -Consiglio Nazionale delle Ricerche [Roma] ( CNR ), Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), National Central University [Taiwan] ( NCU ), Space Science Institute [Macau] ( SSI ), Macau University of Science and Technology ( MUST ), Aix Marseille Université ( AMU ), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] ( IGEP ), and European Space Astronomy Center ( ESAC )
Subjects: 67P/Churyumov-Gerasimenko, Brightness, comets: individual: 67P/Churyumov- Gerasimenko, 010504 meteorology & atmospheric sciences, Comet, Dust particles, Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, space vehicles, comets: general, comets: individual: 67P/Churyumov-Gerasimenko, 01 natural sciences, Astronomi, astrofysik och kosmologi, individual: 67P/Churyumov-Gerasimenko [Comets], 0103 physical sciences, Astronomy, Astrophysics and Cosmology, Phase function, Astrophysics::Solar and Stellar Astrophysics, comets, Particle density, 010303 astronomy & astrophysics, [ SDU.ASTR ] Sciences of the Universe [physics]/Astrophysics [astro-ph], Astrophysics::Galaxy Astrophysics, Comets: individual: 67P/Churyumov, Gerasimenko, 0105 earth and related environmental sciences, Physics, 520 Astronomy, comets: general, comets: individual: 67P/Churyumov-Gerasimenko, general [Comets], Astronomy and Astrophysics, Space vehicles, 620 Engineering, Bulk density, space vehicles, comets: general, comets: individual: 67P/Churyumov- Gerasimenko, Density distribution, 13. Climate action, Space and Planetary Science, [SDU]Sciences of the Universe [physics], space vehicles, Astrophysics::Earth and Planetary Astrophysics, Mass fraction
Abstract: The OSIRIS camera onboard Rosetta measured the phase function of both the coma dust and the nucleus. The two functions have a very different slope versus the phase angle. Here, we show that the nucleus phase function should be adopted to convert the brightness to the size of dust particles larger than 2.5 mm only. This makes the dust bursts observed close to Rosetta by OSIRIS, occurring about every hour, consistent with the fragmentation on impact with Rosetta of parent particles, whose flux agrees with the dust flux observed by GIADA. OSIRIS also measured the antisunward acceleration of the fragments, thus providing the first direct measurement of the solar radiation force acting on the dust fragments and thus of their bulk density, excluding any measurable rocket effect by the ice sublimation from the dust. The obtained particle density distribution has a peak matching the bulk density of most COSIMA particles, and represents a subset of the density distribution measured by GIADA. This implies a bias in the elemental abundances measured by COSIMA, which thus are consistent with the 67P dust mass fractions inferred by GIADA, i.e. (38 ± 8) per cent of hydrocarbons versus the (62 ± 8) per cent of sulphides and silicates.© 2018 The Author(s).Published by Oxford University Press on behalf of the Royal Astronomical Society., We thank the anonymous referee for having significantly improved the paper; and the Rosetta Science Ground Segment at ESAC, the Rosetta Mission Operations Centre at ESOC, and the Rosetta Project at ESTEC for their outstanding work enabling the science return of the Rosetta Mission. All GIADA data presented here are available on request before archiving in the PSA. This research was supported by the Italian Space Agency (ASI) within the ASI-INAF agreements I/032/05/0 and I/024/12/0.
Published: 2018

150. Exposed bright features on the comet 67P/Churyumov-Gerasimenko: distribution and evolution

Author: J. L. Bertaux, L. Jorda, Carsten Güttler, Francesco Marzari, Monica Lazzarin, D. Bodewits, Holger Sierks, V. Da Deppo, Jörg Knollenberg, Nafiseh Masoumzadeh, Giampiero Naletto, Maurizio Pajola, H. U. Keller, Björn Davidsson, Ivano Bertini, Philippe Lamy, Steve Boudreault, O. Groussin, Detlef Koschny, Michael Küppers, Nicolas Thomas, Cecilia Tubiana, J. D. P. Deshapriya, Stefano Debei, M. De Cecco, J. J. Lopez Moreno, Sonia Fornasier, Xian Shi, J. B. Vincent, Stefano Mottola, Pedro J. Gutiérrez, L. M. Lara, Alice Lucchetti, M. A. Barucci, J. Rainer Kramm, R. Rodrigo, N. Oklay, Gabriele Cremonese, Stubbe F. Hviid, Pedro Hasselmann, H. V. Hoang, Marco Fulle, Hans Rickman, F. Preusker, W-H. Ip, Clement Feller, Ekkehard Kührt, Cesare Barbieri, Jakob Deller, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Max-Planck-Institut für Sonnensystemforschung (MPS), Max-Planck-Gesellschaft, INAF - Osservatorio Astronomico di Padova (OAPD), Istituto Nazionale di Astrofisica (INAF), Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' (CISAS), Universita degli Studi di Padova, NASA Ames Research Center (ARC), DLR Institut für Planetenforschung, Deutsches Zentrum für Luft- und Raumfahrt [Berlin] (DLR), Dipartimento di Fisica e Astronomia 'Galileo Galilei', Laboratoire d'Astrophysique de Marseille (LAM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Centre National d'Études Spatiales [Toulouse] (CNES), PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Centro de Astrobiologia [Madrid] (CAB), Instituto Nacional de Técnica Aeroespacial (INTA)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), International Space Science Institute [Bern] (ISSI), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Department of Physics and Astronomy [Uppsala], Uppsala University, Space Research Centre of Polish Academy of Sciences (CBK), Polska Akademia Nauk = Polish Academy of Sciences (PAN), Department of Astronomy [College Park], University of Maryland [College Park], University of Maryland System-University of Maryland System, Laboratory for Ultraviolet and X-ray Optical Research [Padova] (LUXOR), CNR Institute for Photonics and Nanotechnologies (IFN), Consiglio Nazionale delle Ricerche [Roma] (CNR)-Consiglio Nazionale delle Ricerche [Roma] (CNR), Jet Propulsion Laboratory (JPL), California Institute of Technology (CALTECH)-NASA, Department of Industrial Engineering [Padova], University of Trento [Trento], INAF - Osservatorio Astronomico di Trieste (OAT), Instituto de Astrofísica de Andalucía (IAA), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Institute of Space Science [Taiwan], National Central University [Taiwan] (NCU), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] (IGEP), Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], European Space Astronomy Centre (ESAC), Physikalisches Institut [Bern], Universität Bern [Bern], German Centre for Air and Space Travel, Centre National D'Etudes Spatiales (France), Agenzia Spaziale Italiana, Ministerio de Educación y Ciencia (España), European Space Agency, Swedish National Space Board, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), IMPEC - LATMOS, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Instituto Nacional de Técnica Aeroespacial (INTA), Polska Akademia Nauk (PAN), NASA-California Institute of Technology (CALTECH), Consejo Superior de Investigaciones Científicas [Spain] (CSIC), Technische Universität Braunschweig [Braunschweig], Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research (MPS), Università degli Studi di Padova = University of Padua (Unipd), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS), Agence Spatiale Européenne = European Space Agency (ESA), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR)-National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Universität Bern [Bern] (UNIBE), Laboratoire d'études spatiales et d'instrumentation en astrophysique ( LESIA ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Max-Planck-Institut für Sonnensystemforschung ( MPS ), INAF - Osservatorio Astronomico di Padova ( OAPD ), Istituto Nazionale di Astrofisica ( INAF ), NASA Ames Research Center ( ARC ), Deutsches Zentrum für Luft- und Raumfahrt [Berlin] ( DLR ), Laboratoire Atmosphères, Milieux, Observations Spatiales ( LATMOS ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National de la Recherche Scientifique ( CNRS ), Centro de Astrobiologia [Madrid] ( CAB ), Instituto Nacional de Técnica Aeroespacial ( INTA ) -Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), International Space Science Institute ( ISSI ), European Space Research and Technology Centre ( ESTEC ), European Space Agency ( ESA ), Space Research Centre [Warsaw] ( CBK ), Polska Akademia Nauk ( PAN ), Laboratory for Ultraviolet and X-ray Optical Research [Padova] ( LUXOR ), CNR Institute for Photonics and Nanotechnologies ( IFN ), Consiglio Nazionale delle Ricerche [Roma] ( CNR ) -Consiglio Nazionale delle Ricerche [Roma] ( CNR ), Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), INAF - Osservatorio Astronomico di Trieste ( OAT ), Laboratoire d'Astrophysique de Marseille ( LAM ), Aix Marseille Université ( AMU ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Centre National d'Etudes Spatiales ( CNES ) -Centre National de la Recherche Scientifique ( CNRS ), Instituto de Astrofísica de Andalucía ( IAA ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ), National Central University [Taiwan] ( NCU ), Institut für Geophysik und Extraterrestrische Physik [Braunschweig] ( IGEP ), European Space Astronomy Center ( ESAC ), and Centro di Ateneo di Studi e Attività Spaziali 'Giuseppe Colombo' ( CISAS )
Subjects: 010504 meteorology & atmospheric sciences, Comet, Data analysis, 67P/Churyumov–Gerasimenko, Context (language use), Astrophysics, 01 natural sciences, individual: 67P/Churyumov-Gerasimenko [Comets], Methods: data analysis, 0103 physical sciences, Comets: individual: 67P/Churyumov-Gerasimenko, Techniques: photometric, Photometric techniques, data analysis [Methods], 010303 astronomy & astrophysics, [ SDU.ASTR ] Sciences of the Universe [physics]/Astrophysics [astro-ph], 0105 earth and related environmental sciences, Physics, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], biology, photometric [Techniques], Astronomy, Astronomy and Astrophysics, Albedo, biology.organism_classification, Reflectivity, On board, 13. Climate action, Space and Planetary Science, Osiris
Abstract: Context. Since its arrival at the comet 67P/Churyumov-Gerasimenko in August 2014, the Rosetta spacecraft followed the comet as it went past the perihelion and beyond until September 2016. During this time there were many scientific instruments operating on board Rosetta to study the comet and its evolution in unprecedented detail. In this context, our study focusses on the distribution and evolution of exposed bright features that have been observed by OSIRIS, which is the scientific imaging instrument aboard Rosetta. Aims. We envisage investigating various morphologies of exposed bright features and the mechanisms that triggered their appearance. Methods. We co-registered multi-filter observations of OSIRIS images that are available in reflectance. The Lommel-Seeliger disk function was used to correct for the illumination conditions and the resulting colour cubes were used to perform spectrophotometric analyses on regions of interest. Results. We present a catalogue of 57 exposed bright features observed on the nucleus of the comet, all of which are attributed to the presence of HO ice on the comet. Furthermore, we categorise these patches under four different morphologies and present geometric albedos for each category. Conclusions. Although the nucleus of 67P/Churyumov-Gerasimenko appears to be dark in general, there are localised HO ice sources on the comet. Cometary activity escalates towards the perihelion passage and reveals such volatile ices. We propose that isolated HO ice patches found in smooth terrains in regions, such as Imhotep, Bes, and Hapi, result from frost as an aftermath of the cessation of the diurnal water cycle on the comet as it recedes from perihelion. Upon the comet's return to perihelion, such patches are revealed when sublimation-driven erosion removes the thin dust layers that got deposited earlier. More powerful activity sources such as cometary outbursts are capable of revealing much fresher, less contaminated HO ice that is preserved with consolidated cometary material, as observed on exposed patches resting on boulders. This is corroborated by our albedo calculations that attribute higher albedos for bright features with formations related to outbursts.© ESO 2018., The support of the national funding agencies of Germany (DLR), France (CNES), Italy (ASI), Spain (MEC), Sweden (SNSB), and the ESA Technical Directorate is gratefully acknowledged.
Published: 2018

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