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498 results on '"Petrakis, Ismene L."'

103. Contributors

Author

Acheson, Ashley, Addolorato, Giovanni, Antonelli, Mariangela, Arnaout, Bachaar, Atkinson, David L., Baldwin, Jeffrey N., Baldwin, Peter A., Bardo, Michael T., Balodis, Iris M., Barry, Danielle, Barry, Kristen Lawton, Beech, Robert, Bernstein, Amit, Bierer, Michael F., Black, David S., Blevins, Derek, Blow, Frederic C., Bonci, Antonello, Bonn-Miller, Marcel O., Breton, Marc D., Brower, Kirk J., Brown, Qiana L., Buelt, Eliza, Caputo, Fabio, Cardullo, Stefano, Carter, Jacqueline C., Chang, Joy, Cheer, Joseph F., Chen, Shih-Fen, Cinciripini, Paul M., Clark, H. Westley, Coleman, Leon G., Jr., Collins, Gregory T., Corno, Catherine, Covey, Dan P., Crews, Fulton T., Cropsey, Karen L., Cservenka, Anita, Cushenberry, Leon, Cristina d’Angelo, Dantrassy, Hannah M., Davis, Caroline, Davis, Matt, Diazgranados, Nancy, Deitch, David A., Gomez-Perez, Luis J., DiClemente, Carlo C., Dionisi, Tommaso, Dodge, Brian M., Drago, Liliane, Dwoskin, Linda P., Eldridge, Gloria D., Elkashef, Ahmed, Ertelt, Troy W., Eyrich-Garg, Karin M., Farris, Samantha G., Fernandez, Francisco, Ferrulli, Anna, Forcehimes, Alyssa A., Fuller, Shauna, Gallimberti, Luigi, Gasbarrini, Antonio, Gendel, Michael H., Gerak, Lisa R., Ginsburg, Brett C., Gipson, Cassandra D., Glaser, Paul E.A., Goldman, David, Goodkin, Karl, Grant, Jon E., Graydon, Meagan, Grisham, Jessica R., Guàrdia, Marc Grifell, Halpern, John H., Hankosky, Emily R., Hart, Carl L., Hasin, Deborah, Hawken, Angela, Hemby, Scott E., Holmgren Shaw, Meredith A., Hove, M. Christina, Huang, Hanyun, Huertas, Pedro E., Hulse, Gary K., Hutchison, Kent E., Ingersoll, Karen S., Jackson, Dorothy O., James, Jack E., Javors, Martin A., Johnson, Bankole A., Johnson, Jeannette L., Kadib, Raja, Karam-Hage, Maher, Keller, Asaf, Kendell, Steven F., Kenny, Therese E., Keyes, Katherine, Khanna, Surbhi, King, Thomas S., Knoblach, Daniel, Koob, George F., Kovatchev, Boris P., Kulick, Jonathan D., Kumpfer, Karol L., Kushner, Howard I., Lancaster, Kathy, Langdon, Kirsten J., Latt, Noeline C., Lawson, William B., Lee, Nicole, Leggio, Lorenzo, Lev-Ran, Shaul, Lewis, David C., Leyro, Teresa M., Lobo, Mary Kay, Lovinger, David M., Luoma, Jason B., Lynch, Wendy J., Madeo, Graziella, Malcolm, Robert, Marinoa, Joanna M., Marzani, Gabrielle, McBride, Kimberly R., Minnix, Jennifer, Mirijello, Antonio, Mitchell, James E., Moos, Rudolf H., Mosoni, Carolina, Neighbors, Clayton, Nesil, Tanseli, North, Carol S., Olive, M. Foster, Ornoy, Asher, Pachano, Gabriela, Penberthy, J. Kim, Penberthy, J. Morgan, Petersen, Daena L., Petrakis, Ismene L., Petry, Nancy M., Pokhrel, Pallav, Pollio, David E., Potenza, Marc N., Rando, Maria Margherita, Ray, Lara A., Reece, Michael, Renner, John A., Riggs, Nathaniel R., Roache, John D., Rounsaville, Daniel, Saitz, Richard, Saunders, John B., Schiavon, Samantha P., Schnoll, Sidney H., Seneviratne, Chamindi, Sestito, Luisa, Shen, Yu-Chih, Singh, Shiva M., Sinha, Rajita, Spanagel, Rainer, Stoltenberg, Scott F., Sussman, Steve, Suzuki, Joji, Tait, Robert, Tannu, Nilesh S., Tarli, Claudia, Taxman, Faye S., Terraneo, Alberto, Timko, Christine, Daoud Tiouririne, Nassima Ait, Tonigan, J. Scott, Trinkoff, Alison, Uddin, Raihan K., Vassallo, Gabriele Angelo, Vaughan, Michelle, Vocci, Frank, Wagner, Christopher C., Weaver, Michael F., Welsh, Christopher, Westreich, Laurence M., Williams, Alishia D., Wiprovnick, Alicia, Yacobi, Sarah, Young, Chelsie M., Young, L. Brendan, Zaman, Adnin, and Zvolensky, Michael J.

Published
2020
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104. Schizophrenia and Substance Abuse: Is There a Role for Atypical Antipsychotics?

Author

Petrakis, Ismene L.

Subjects
Comorbidity -- Patient outcomes -- Drug therapy, Schizophrenics -- Drug therapy -- Patient outcomes, Antipsychotic drugs -- Dosage and administration -- Patient outcomes, Substance abusers -- Drug therapy -- Patient outcomes, Health, Psychology and mental health
Abstract

Byline: Ismene L. Petrakis, MD The prevalence of substance use disorders in patients with schizophrenia is greater than the rate observed in the general population,1 with a dramatic increase since [...]

Published
2007

108. Sex differences in cocaine-dependent individuals' response to disulfiram treatment

Author

Nich, Carla, McCance-Katz, Elinore F., Petrakis, Ismene L., Cubells, Joseph F., Rounsaville, Bruce J., and Carroll, Kathleen M.

Subjects
Cocaine abuse -- Care and treatment, Drug addicts -- Sexual behavior, Health, Sociology and social work
Abstract

The differential response to disulfiram treatment of cocaine dependence on the basis of sex is evaluated through randomized clinical trials with one hundred and ninety-one cocaine-dependent subjects. The men undergoing disulfiram treatment showed good results as compared to those without the disulfiram treatment, whereas the women showed intermediate outcomes irrespective of the disulfiram treatment.

Published
2004

114. Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism

Author

Petrakis, Ismene L, Kerfoot, Karin, Pittman, Brian, Perrino, Albert, Koretski, Julia, Newcomb, Jenelle, Limoncelli, Diana, Acampora, Gregory, and Ralevski, Elizabeth

Subjects
Article
Abstract

The development of alcohol use disorders is genetically influenced, and may be mediated through differences in the subjective response to alcohol. There is some evidence to suggest that response differences to alcohol could be conveyed by heritable differences in GABA73 subjects (24 FHP and 49 FHN) between the ages of 21 and 30 years were administered sub-anesthetic doses of the GABASub-anesthetic doses of thiopental produced alcohol-like subjective effects, as well as alcohol-like impaired coordination and cognition in healthy subjects. While there were no significant main effects in subjective, coordination, or cognitive effects between FHP and FHN individuals, analysis of peak effects suggested FHP had blunted sedative, but not stimulant effects compared to FHN.Thiopental produced alcohol-like effects and perceived similarities to alcohol in healthy individuals. Subtle differences in sedative effects are consistent with reports of blunted FHP response to the negative but not stimulant effects of alcohol. Future studies are needed to better understand how this insight informs our understanding of the heritable risk for alcoholism and the treatment of alcohol use disorders.

Published
2012

116. Prazosin for Treatment of Patients with PTSD and Comorbid Alcohol Dependence

Author

YALE UNIV NEW HAVEN CT, Petrakis, Ismene L, Ralevski, Elizabeth, YALE UNIV NEW HAVEN CT, Petrakis, Ismene L, and Ralevski, Elizabeth

Abstract

There is a high rate of comorbidity with alcohol dependence (AD) and post traumatic stress disorder (PTSD). The rates of TSD among individuals with AD are at least twice as high as those in the general population. In addition, alcohol dependence is the most common comorbid condition in men with PTSD. Despite this, little is known about how to best treat individuals with comorbid AD and PTSD. The use of an alpha-1 adrenergic receptor antagonist represents a novel approach to treatment that may target symptoms of both AD and PTSD. There is evidence of common neurobiological mechanisms that underlie both AD and PTSD. Prazosin is an alpha-1 adrenergic receptor antagonist that has been used successfully in the treatment of trauma nightmares and sleep disturbance in combat veterans with TSD, and alcohol dependence. Objective: The objective of this study is to evaluate the efficacy of prazosis (16mg) versus placebo in reducing alcohol consumption and increasing symptoms of PTSD in patients with comorbid AD and PTSD. Methods: One hundred and twenty participants with a current diagnosis of AD and PTSD will be enrolled in a 13-week trial. They will be assigned, in a double-blind fashion, to either prazosin or placebo. findings: No fmdings are yet available for this study. Significance: This project will be the first to compare prazosin to placebo as effective treatments for reducing alcohol consumption and PTSD symptoms in patients with both AD and PTSD., The original document contains color images.

Published
2014

117. Altered NMDA Glutamate Receptor Antagonist Response in Individuals With a Family Vulnerability to Alcoholism

Author

Trevisan, Louis, Limoncelli, Diana, Gueorguieva, Ralitza, Frances, R. J., Jatlow, Peter, Petrakis, Ismene L., Boutros, Nashaat N., Gelernter, Joel, and Krystal, John H.

Abstract

OBJECTIVE: A family history of alcoholism is a risk factor for the development of ethanol dependence. Ethanol is an antagonist of the N-methyl-d-aspartate (NMDA) glutamate receptor, and alterations in NMDA receptor function are thought to be involved in ethanol abuse and dependence. The purpose of this study was to determine in healthy individuals with no ethanol dependence whether response to the NMDA receptor antagonist ketamine would differentiate those with a family history of ethanol dependence from those without such a family history. METHOD: Healthy subjects between the ages of 21 and 30 received 40-minute intravenous infusions of saline, low-dose ketamine (0.1 mg/kg), and high-dose ketamine (0.5 mg/kg) on three separate test days in a randomized order under double-blind conditions. The healthy individuals with at least one first-degree relative and another first- or second-degree relative with ethanol dependence (N=16) were compared with those who had no family history of ethanol dependence in any first- or second-degree relative (N=29). Outcome measures included the Brief Psychiatric Rating Scale, Clinician-Administered Dissociative States Scale, verbal fluency, Hopkins Verbal Learning Test, a biphasic alcohol effects scale, visual analog scales of mood states, and ketamine levels. RESULTS: During ketamine infusion, individuals with a family history of ethanol dependence showed an attenuated response in terms of perceptual alterations and dysphoric mood relative to those without such a family history. CONCLUSIONS: These data suggest that alterations in NMDA receptor function may contribute to subjective response to ethanol and therefore also to the risk of developing alcoholism.

Published
2006

120. Prazosin for Treatment of Patients With PTSD and Comorbid Alcohol Dependence

Author

YALE UNIV NEW HAVEN CT, Petrakis, Ismene L, Ralevski, Elizabeth, YALE UNIV NEW HAVEN CT, Petrakis, Ismene L, and Ralevski, Elizabeth

Abstract

There is a high rate of comorbidity with alcohol dependence (AD) and post traumatic stress disorder (PTSD). The rates of PTSD among individuals with AD are at least twice as high as those in the general population. In addition, alcohol dependence is the most common comorbid condition in men with PTSD. Despite this, little is known about how to best treat individuals with comorbid AD and PTSD. The use of an alpha-1 adrenergic receptor antagonist represents a novel approach to treatment that may target symptoms of both AD nd PTSD. There is evidence of common neurobiological mechanisms that underlie both AD and PTSD. Prazosin is an alpha-1 adrenergic receptor antagonist that has been used successfully in the treatment of trauma nightmares and sleep disturbance in combat veterans with PTSD, and alcohol dependence. Objective: The objective of this study is to evaluate the efficacy of prazosis (16mg) versus placebo in reducing alcohol consumption and decreasing symptoms of PTSD in patients with comorbid AD and PTSD. Methods: One hundred and twenty participants with a current diagnosis of AD and PTSD will be enrolled in a 13-week trial. They will be assigned, in a double-blind fashion, to either prazosin or placebo. Findings: No findings are yet available for this study. Significance: This project will be the first to compare prazosin to placebo as effective treatments for reducing alcohol consumption and PTSD symptoms in patients with both AD and PTSD., The original document contains color images.

Published
2013

121. GRIK1and GABRA2Variants Have Distinct Effects on the Dose‐Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers

Author

Yang, Bao‐Zhu, Arias, Albert J., Feinn, Richard, Krystal, John H., Gelernter, Joel, and Petrakis, Ismene L.

Abstract

The heritable risk for alcohol use disorder (AUD) is expressed partly through alterations in subjective alcohol response. In this study, we investigated the effects of 2 AUD‐risk‐associated single nucleotide polymorphisms, GABRA2rs279858 and GRIK1rs2832407, on the subjective response to alcohol administered intravenously to healthy social drinkers in a laboratory setting. In total, 93 self‐identified European American social drinkers underwent 3 blinded laboratory sessions in which they received intravenous infusions of ethanol at 3 target blood alcohol levels (0.00 mg%, 40 mg%, and 100 mg%) using a “clamp” procedure. The self‐reported Biphasic Alcohol Effects Scale (BAES) stimulation and sedation subscales were the primary outcome measures. We examined the effects of these 2 genetic variants on subjective response to alcohol. For the BAESstimulation subscale scores, adjusting for age, baseline scores, and time effects, individuals with 2 copies of the GABRA2rs279858 C “risk” allele for AUDexhibited the greatest stimulant responses to high‐dose alcohol compared to the other risk allele counts (dose‐by‐allele count interaction effect, p = 0.001, post hoc contrast for C‐allele, p =0.012). For the BAESsedation subscale scores, adjusting for the same covariates, we detected a dose‐by‐allele count interaction effect (p =0.0044) such that subjects with 2 copies of the GRIK1C “risk” allele reported the greatest sedative response to the higher alcohol dose. This study suggests that gene variants contributing to the risk for AUDmay alter features of the alcohol dose–response relationship in specific ways. GABRA2rs279858*C enhances stimulant responses to higher levels of alcohol, while the GRIK1rs2832407*C‐allele increases sedative responses. In summary, GRIK1and GABRA2variants have distinct effects on the dose‐related subjective response to intravenous alcohol in humans. We investigated the effects of two alcohol use disorder (AUD) risk‐associated genetic variants, GABRA2rs279858 and GRIK1rs2832407, on the subjective response to alcohol in social drinkers. Individuals carrying the GABRA2rs279858 C “risk” allele exhibited the greatest stimulant responses to high dose alcohol. Subjects with two copies of the GRIK1C “risk” allele reported the greatest sedative response. The altered responses in persons with these variants may increase the reward from drinking, perhaps conveying increased risk of AUD.

Published
2017
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122. Intravenous Ethanol Infusion Decreases Human Cortical γ-Aminobutyric Acid and N-Acetylaspartate as Measured with Proton Magnetic Resonance Spectroscopy at 4 Tesla

Author

Gomez, Rosane, primary, Behar, Kevin L., additional, Watzl, June, additional, Weinzimer, Stuart A., additional, Gulanski, Barbara, additional, Sanacora, Gerard, additional, Koretski, Julia, additional, Guidone, Elizabeth, additional, Jiang, Lihong, additional, Petrakis, Ismene L., additional, Pittman, Brian, additional, Krystal, John H., additional, and Mason, Graeme F., additional

Published
2012
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127. Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers

Author

McKee, Sherry A., primary, Harrison, Emily L.R., additional, O'Malley, Stephanie S., additional, Krishnan-Sarin, Suchitra, additional, Shi, Julia, additional, Tetrault, Jeanette M., additional, Picciotto, Marina R., additional, Petrakis, Ismene L., additional, Estevez, Naralys, additional, and Balchunas, Erika, additional

Published
2009
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130. Absence of Significant Interactive Effects of High-Dose d-Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors

Author

Trevisan, Louis, primary, Petrakis, Ismene L., additional, Pittman, Brian, additional, Gueorguieva, Ralitza, additional, D’Souza, D. Cyril, additional, Perry, Edward, additional, Limoncelli, Diana, additional, and Krystal, John H., additional

Published
2007
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135. Mazindol Augmentation of Antipsychotic Treatment for Schizophrenic Patients with Comorbid Cocaine Abuse or Dependence

Author

Perry, Edward B., primary, Gil, Roberto, additional, Miles, Deborah, additional, Brenner, Louise, additional, Macdougall, Lisa, additional, Johnson, Robin, additional, Degen, Kathleen, additional, Gueorguieva, Ralitza, additional, Petrakis, Ismene L., additional, Krystal, John H., additional, and D'Souza, D. Cyril, additional

Published
2005
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137. Sedative-Hypnotics and Anxiolytics.

Author

Arnaout, Bachaar and Petrakis, Ismene L.

Abstract

The sedative-hypnotics and anxiolytics are central nervous system depressants that have a wide array of uses in psychiatry, neurology, anesthesiology, and general medicine. These medications include the benzodiazepines, the new-generation non-benzodiazepine hypnotics, the barbiturates, and other agents. Despite their therapeutic value, they have been associated with misuse, abuse, and dependence, and may cause an array of medical and psychiatric adverse events. In this chapter, we introduce this group of medications and discuss the epidemiology of their non-medical use, as well as recommendations pertaining to the prevention and management of their deleterious effects, including: intoxication and overdose, tolerance and withdrawal, abuse and dependence, mood and anxiety disorders, cognitive disorders, psychotic manifestations, sleep disorders, and sexual dysfunction. [ABSTRACT FROM AUTHOR]

Published
2011
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143. Correction to: Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial

Author

Abdallah, Chadi G., Roache, John D., Gueorguieva, Ralitza, Averill, Lynnette A., Young-McCaughan, Stacey, Shiroma, Paulo R., Purohit, Prerana, Brundige, Antoinette, Murff, William, Ahn, Kyung-Heup, Sherif, Mohamed A., Baltutis, Eric J., Ranganathan, Mohini, D’Souza, Deepak, Martini, Brenda, Southwick, Steven M., Petrakis, Ismene L., Burson, Rebecca R., Guthmiller, Kevin B., López-Roca, Argelio L., Lautenschlager, Karl A., McCallin, John P., Hoch, Matthew B., Timchenko, Alexandar, Souza, Sergio E., Bryant, Charles E., Mintz, Jim, Litz, Brett T., Williamson, Douglas E., Keane, Terence M., Peterson, Alan L., and Krystal, John H.

Published
2022
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147. Preliminary Evidence of Low Cortical GABA Levels in Localized1H-MR Spectra of Alcohol-Dependent and Hepatic Encephalopathy Patients

Author

Behar, Kevin L., primary, Rothman, Douglas L., additional, Petersen, Kitt F., additional, Hooten, Michael, additional, Delaney, Richard, additional, Petroff, Ognen A.C., additional, Shulman, Gerald I., additional, Navarro, Victor, additional, Petrakis, Ismene L., additional, Charney, Dennis S., additional, and Krystal, John H., additional

Published
1999
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148. Naltrexone Augmentation of Neuroleptics in Schizophrenia

Author

Sernyak, Michael J., primary, Glazer, William M., additional, Heninger, George R., additional, Charney, Dennis S., additional, Woods, Scott W., additional, Petrakis, Ismene L., additional, Krystal, John H., additional, and Price, Lawrence H., additional

Published
1998
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