649 results on '"Peter J Hutchinson"'
Search Results
102. Variability of the Optic Nerve Sheath Diameter on the Basis of Sex and Age in a Cohort of Healthy Volunteers
- Author
-
Francesco Corradi, Anna Di Noto, Marek Czosnyka, Peter J. Hutchinson, Alessandro Bertuccio, Danilo Cardim, Paolo Pelosi, Karthikka Chandrapatham, Chiara Robba, and Joseph Donnelly
- Subjects
medicine.medical_specialty ,Optic nerve sheath ,integumentary system ,business.industry ,Healthy population ,Age and sex ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Ophthalmology ,Cohort ,Healthy volunteers ,medicine ,Ultrasonography ,business ,Pathological ,030217 neurology & neurosurgery ,Intracranial pressure - Abstract
Many studies have demonstrated that the optic nerve sheath diameter (ONSD) is a good indicator of intracranial pressure (ICP). There are uncertainties regarding the optimal ONSD threshold, considering age and sex differences in the healthy population, and these differences could lead to uncertainties in evaluation of ONSD in pathological conditions.
- Published
- 2021
103. Elective cancer surgery in COVID-19–Free surgical pathways during the SARS-cov-2 pandemic: An international, multicenter, comparative cohort study
- Author
-
James C Glasbey, Dmitri Nepogodiev, Joana Ff Simoes, Omar Omar, Elizabeth Li, Mary L Venn, Mohammad Abou Chaar, Vita Capizzi, Daoud Chaudhry, Anant Desai, Jonathan G Edwards, Jonathan P Evans, Marco Fiore, Jose Flavio Videria, Samuel J Ford, Ian Ganyli, Ewen A Griffiths, Rohan R Gujjuri, Angelos G Kolias, Haytham Ma Kaafarani, Ana Minaya-Bravo, Siobhan C McKay, Helen M Mohan, Keith Roberts, Carlos San Miguel-Méndez, Peter Pockney, Richard Shaw, Neil J Smart, Grant D Stewart, Sudha Sundar, Raghavan Vidya, Aneel A Bhangu, James C Glasbey, Omar Omar, Aneel A Bhangu, Kwabena Siaw-Acheampong, Ruth A Benson, Edward Bywater, Daoud Chaudhry, Brett E Dawson, Jonathan P Evans, James C Glasbey, Rohan R Gujjuri, Emily Heritage, Conor S Jones, Sivesh K Kamarajah, Chetan Khatri, Rachel A Khaw, James M Keatley, Andrew Knight, Samuel Lawday, Elizabeth Li, Harvinder S Mann, Ella J Marson, Kenneth A McLean, Siobhan C McKay, Emily C Mills, Dmitri Nepogodiev, Gianluca Pellino, Maria Picciochi, Elliott H Taylor, Abhinav Tiwari, Joana Ff Simoes, Isobel M Trout, Mary L Venn, Richard Jw Wilkin, Aneel A Bhangu, James C Glasbey, Neil J Smart, Ana Minaya-Bravo, Jonathan P Evans, Gaetano Gallo, Susan Moug, Francesco Pata, Peter Pockney, Salomone Di Saverio, Abigail Vallance, Dale Vimalchandran, Ewen A Griffiths, Sivesh K Kamarajah, Richard Pt Evans, Philip Townend, Keith Roberts, Siobhan McKay, John Isaac, Sohei Satoi, John Edwards, Aman S Coonar, Adrian Marchbank, Edward J Caruana, Georgia R Layton, Akshay Patel, Alessandro Brunelli, Samuel Ford, Anant Desai, Alessandro Gronchi, Marco Fiore, Max Almond, Fabio Tirotta, Sinziana Dumitra, Angelos Kolias, Stephen J Price, Daniel M Fountain, Michael D Jenkinson, Peter Hutchinson, Hani J Marcus, Rory J Piper, Laura Lippa, Franco Servadei, Ignatius Esene, Christian Freyschlag, Iuri Neville, Gail Rosseau, Karl Schaller, Andreas K Demetriades, Faith Robertson, Alex Alamri, Richard Shaw, Andrew G Schache, Stuart C Winter, Michael Ho, Paul Nankivell, Juan Rey Biel, Martin Batstone, Ian Ganly, Raghavan Vidya, Alex Wilkins, Jagdeep K Singh, Dinesh Thekinkattil, Sudha Sundar, Christina Fotopoulou, Elaine Leung, Tabassum Khan, Luis Chiva, Jalid Sehouli, Anna Fagotti, Paul Cohen, Murat Gutelkin, Rahel Ghebre, Thomas Konney, Rene Pareja, Rob Bristow, Sean Dowdy, T S Shylasree, R Kottayasamy Seenivasagam, Joe Ng, Keiiji Fujiwara, Grant D Stewart, Benjamin Lamb, Krishna Narahari, Alan McNeill, Alexandra Colquhoun, John McGrath, Steve Bromage, Ravi Barod, Veeru Kasivisvanathan, Tobias Klatte, Joana Ff Simoes, Tom Ef Abbott, Sadi Abukhalaf, Michel Adamina, Adesoji O Ademuyiwa, Arnav Agarwal, Murat Akkulak, Ehab Alameer, Derek Alderson, Felix Alakaloko, Markus Albertsmeiers, Osaid Alser, Muhammad Alshaar, Sattar Alshryda, Alexis P Arnaud, Knut Magne Augestad, Faris Ayasra, José Azevedo, Brittany K Bankhead-Kendall, Emma Barlow, David Beard, Ruth A Benson, Ruth Blanco-Colino, Amanpreet Brar, Ana Minaya-Bravo, Kerry A Breen, Chris Bretherton, Igor Lima Buarque, Joshua Burke, Edward J Caruana, Mohammad Chaar, Sohini Chakrabortee, Peter Christensen, Daniel Cox, Moises Cukier, Miguel F Cunha, Giana H Davidson, Anant Desai, Salomone Di Saverio, Thomas M Drake, John G Edwards, Muhammed Elhadi, Sameh Emile, Shebani Farik, Marco Fiore, J Edward Fitzgerald, Samuel Ford, Tatiana Garmanova, Gaetano Gallo, Dhruv Ghosh, Gustavo Mendonça Ataíde Gomes, Gustavo Grecinos, Ewen A Griffiths, Madalegna GrÜndl, Constantine Halkias, Ewen M Harrison, Intisar Hisham, Peter J Hutchinson, Shelley Hwang, Arda Isik, Michael D Jenkinson, Pascal Jonker, Haytham Ma Kaafarani, Debby Keller, Angelos Kolias, Schelto Kruijff, Ismail Lawani, Hans Lederhuber, Sezai Leventoglu, Andrey Litvin, Andrew Loehrer, Markus W Löffler, Maria Aguilera Lorena, Maria Marta Modolo, Piotr Major, Janet Martin, Hassan N Mashbari, Dennis Mazingi, Symeon Metallidis, Ana Minaya-Bravo, Helen M Mohan, Rachel Moore, David Moszkowicz, Susan Moug, Joshua S Ng-Kamstra, Mayaba Maimbo, Ionut Negoi, Milagros Niquen, Faustin Ntirenganya, Maricarmen Olivos, Kacimi Oussama, Oumaima Outani, Marie Dione Parreno-Sacdalanm, Francesco Pata, Carlos Jose Perez Rivera, Thomas D Pinkney, Willemijn van der Plas, Peter Pockney, Ahmad Qureshi, Dejan Radenkovic, Antonio Ramos-De la Medina, Keith Roberts, April C Roslani, Martin Rutegård, Juan José Segura-Sampedro, Irène Santos, Sohei Satoi, Raza Sayyed, Andrew Schache, Andreas A Schnitzbauer, Justina O Seyi-Olajide, Neil Sharma, Richard Shaw, Sebastian Shu, Kjetil Soreide, Antonino Spinelli, Grant D Stewart, Malin Sund, Sudha Sundar, Stephen Tabiri, Philip Townend, Georgios Tsoulfas, Gabrielle H van Ramshorst, Raghavan Vidya, Dale Vimalachandran, Oliver J Warren, Duane Wedderburn, Naomi Wright, C Allemand, L Boccalatte, M Figari, M Lamm, J Larrañaga, C Marchitelli, F Noll, D Odetto, M Perrotta, J Saadi, L Zamora, C Alurralde, E L Caram, D Eskinazi, J P Mendoza, M Usandivaras, R Badra, A Esteban, J S García, P M García, J I Gerchunoff, S M Lucchini, M A NIgra, L Vargas, T Hovhannisyan, A Stepanyan, T Gould, R Gourlay, B Griffiths, S Gananadha, M McLaren, J Cecire, N Joshi, S Salindera, A Sutherland, J H Ahn, G Charlton, S Chen, N Gauri, R Hayhurst, S Jang, F Jia, C Mulligan, W Yang, G Ye, H Zhang, M Ballal, D Gibson, D Hayne, J Moss, T Richards, P Viswambaram, U G Vo, J Bennetts, T Bright, M Brooke-Smith, R Fong, B Gricks, Y H Lam, B S Ong, M Szpytma, D Watson, K Bagraith, S Caird, E Chan, C Dawson, D Ho, E Jeyarajan, S Jordan, A Lim, G J Nolan, A Oar, D Parker, H Puhalla, A Quennell, L Rutherford, P Townend, M Von Papen, M Wullschleger, A Blatt, D Cope, N Egoroff, M Fenton, J Gani, N Lott, P Pockney, N Shugg, M Elliott, D Phung, D Phan, D Townend, C Bong, J Gundara, A Frankel, S Bowman, G R Guerra, J Bolt, K Buddingh, N N Dudi-Venkata, S Jog, H M Kroon, T Sammour, R Smith, C Stranz, M Batstone, K Lah, W McGahan, D Mitchell, A Morton, A Pearce, M Roberts, G Sheahan, B Swinson, N Alam, S Banting, L Chong, P Choong, S Clatworthy, D Foley, A Fox, M W Hii, B Knowles, J Mack, M Read, A Rowcroft, S Ward, G Wright, M Lanner, I Königsrainer, M Bauer, C Freyschlag, M Kafka, F Messner, D Öfner, I Tsibulak, K Emmanuel, M Grechenig, R Gruber, M Harald, L Öhlberger, J Presl, A Wimmer, I Namazov, E Samadov, D Barker, R Boyce, S Corbin, A Doyle, A Eastmond, R Gill, A Haynes, S Millar, M O'Shea, G Padmore, N Paquette, E Phillips, S St John, K Walkes, N Flamey, P Pattyn, W Oosterlinck, J Van den Eynde, R Van den Eynde, A Gatti, C Nardi, R Oliva, R De Cicco, I Cecconello, P Gregorio, L Pontual Lima, U Ribeiro Junior, F Takeda, R M Terra, M Sokolov, B Kidane, S Srinathan, M Boutros, N Caminsky, G Ghitulescu, G Jamjoum, J Moon, J Pelletier, T Vanounou, S Wong, M Boutros, S Dumitra, A Kouyoumdjian, B Johnston, C Russell, M Boutros, S Demyttenaere, R Garfinkle, J Abou-Khalil, C Nessim, J Stevenson, F Heredia, A Almeciga, A Fletcher, A Merchan, L O Puentes, J Mendoza Quevedo, G Bacic, D Karlovic, D Krsul, M Zelic, I Luksic, M Mamic, B Bakmaz, I Coza, E Dijan, Z Katusic, J Mihanovic, I Rakvin, K Frantzeskou, N Gouvas, G Kokkinos, P Papatheodorou, I Pozotou, O Stavrinidou, A Yiallourou, L Martinek, M Skrovina, I Szubota, J Žatecký, V Javurkova, J Klat, T Avlund, P Christensen, J L Harbjerg, L H Iversen, D W Kjaer, Hø Kristensen, M Mekhael, A L Ebbehøj, P Krarup, N Schlesinger, H Smith, A Abdelsamed, A Y Azzam, H Salem, A Seleim, A Abdelmajeed, M Abdou, N E Abosamak, M Al Sayed, F Ashoush, R Atta, E Elazzazy, M Elhoseiny, M Elnemr, M S Elqasabi, M E Elsayed Hewalla, I Elsherbini, E Essam, M Eweda, I Ghallab, E Hassan, M Ibrahim, M Metwalli, M Mourad, M S Qatora, M Ragab, A Sabry, H Saifeldin, M Saleh Mesbah Mohamed Elkaffas, A Samih, A Samir Abdelaal, S Shehata, K Shenit, D Attia, N Kamal, N Osman, A M Abbas, Has Abd Elazeem, M M Abdelkarem, S Alaa, A K Ali, A Ayman, M G Azizeldine, H Elkhayat, S M Elghazaly, F A Monib, M A Nageh, M M Saad, M Salah, M Shahine, E A Yousof, A Youssef, A Eldaly, M ElFiky, A Nabil, G Amira, I Sallam, M Sherief, A Sherif, A Abdelrahman, H Aboulkassem, G Ghaly, R Hamdy, A Morsi, H Salem, G Sherif, H Abdeldayem, I Abdelkader Salama, M Balabel, Y Fayed, A E Sherif, D Bekele, J Kauppila, E Sarjanoja, O Helminen, H Huhta, J H Kauppila, C Beyrne, L Jouffret, L Lugans, L Marie-Macron, E Chouillard, B De Simone, J Bettoni, S Dakpé, B Devauchelle, N Lavagen, S Testelin, S Boucher, R Breheret, A Gueutier, A Kahn, J KÜn-Darbois, A Barrabe, Z Lakkis, A Louvrier, S Manfredelli, P Mathieu, A Chebaro, V Drubay, M El Amrani, C Eveno, K Lecolle, G Legault, L Martin, G Piessen, F R Pruvot, S Truant, P Zerbib, Q Ballouhey, B Barrat, J Laloze, H Salle, A Taibi, J Usseglio, D Bergeat, A Merdrignac, Roy B Le, L O Perotto, A Scalabre, A Aimé, A Ezanno, B Malgras, P Bouche, S Tzedakis, E Cotte, O Glehen, V Kepenekian, J Lifante, G Passot, A D'Urso, E Felli, D Mutter, P Pessaux, B Seeliger, J Bardet, R Berry, G Boddaert, S Bonnet, E Brian, C Denet, D Fuks, D Gossot, M Grigoroiu, A Laforest, Y Levy-Zauberman, C Louis-Sylvestre, A Moumen, G Pourcher, A Seguin-Givelet, E Tribillon, E Duchalais, F Espitalier, C Ferron, O Malard, U Bork, M Distler, J Fritzmann, J Kirchberg, C Praetorius, C Riediger, J Weitz, T Welsch, P Wimberger, K Beyer, C Kamphues, J Lauscher, F N Loch, C Schineis, M Albertsmeier, M Angele, A Kappenberger, H Niess, T Schiergens, J Werner, R Becker, J Jonescheit, I Pergolini, D Reim, C Boeker, I Hakami, J Mall, P Liokatis, W Smolka, K Nowak, T Reinhard, F Hölzle, A Modabber, P Winnand, M Knitschke, P Kauffmann, S Wolfer, J Kleeff, K Lorenz, C Michalski, U Ronellenfitsch, R Schneider, E Bertolani, A Königsrainer, M W Löffler, M Quante, C Steidle, L ÜberrÜck, C Yurttas, C S Betz, J Bewarder, A Böttcher, S Burg, C Busch, M Gosau, A Heuer, J Izbicki, T O Klatte, D Koenig, N Moeckelmann, C Nitschke, M Priemel, R Smeets, U Speth, S Thole, F G Uzunoglu, T Vollkommer, N Zeller, M J Battista, K Gillen, A Hasenburg, S Krajnak, V Linz, R Schwab, K Angelou, D Haidopoulos, A Rodolakis, P Antonakis, K Bramis, L Chardalias, I Contis, N Dafnios, D Dellaportas, G Fragulidis, A Gklavas, M Konstadoulakis, N Memos, I Papaconstantinou, A Polydorou, T Theodosopoulos, A Vezakis, M I Antonopoulou, D K Manatakis, N Tasis, N Arkadopoulos, N Danias, P Economopoulou, P Kokoropoulos, A Larentzakis, N Michalopoulos, J Selmani, T Sidiropoulos, V Tsaousis, P Vassiliu, K Bouchagier, S Klimopoulos, D Paspaliari, G Stylianidis, K Baxevanidou, K Bouliaris, P Chatzikomnitsa, M Efthimiou, A Giaglaras, C Kalfountzos, G Koukoulis, A M Ntziovara, K Petropoulos, K Soulikia, I Tsiamalou, K Zervas, S Zourntou, I Baloyiannis, A Diamantis, E Gkrinia, J Hajiioannou, C Korais, O Koukoura, K Perivoliotis, A Saratziotis, C Skoulakis, D Symeonidis, K Tepetes, G Tzovaras, D Zacharoulis, V Alexoudi, K Antoniades, I Astreidis, P Christidis, D Deligiannidis, T Grivas, O Ioannidis, I Kalaitsidou, L Loutzidou, A Mantevas, D Michailidou, K Paraskevopoulos, S Politis, A Stavroglou, D Tatsis, I Tilaveridis, K Vahtsevanos, G Venetis, I Karaitianos, T Tsirlis, A Charalabopoulos, T Liakakos, E Mpaili, D Schizas, E Spartalis, A Syllaios, C Zografos, C Anthoulakis, C Christou, V Papadopoulos, A Tooulias, D Tsolakidis, G Tsoulfas, D Zouzoulas, E Athanasakis, E Chrysos, J Tsiaoussis, S Xenaki, E Xynos, K Futaba, M F Ho, S F Hon, Twc Mak, Ssm Ng, C C Foo, B Banky, N Suszták, M Aremu, A Canas-Martinez, O Cullivan, C Murphy, P Owens, L Pickett, L Akmenkalne, J Byrne, M Corrigan, C Cullinane, A Daly, C Fleming, P Jordan, S Killeen, N Lynch, A McCarthy, H Mustafa, S O'Brien, P O'Leary, Was Syed, L Vernon, D Callanan, L Huang, A Ionescu, P Sheahan, I Balasubramanian, M Boland, K Conlon, D Evoy, N Fearon, T Gallagher, J Geraghty, H Heneghan, N Kennedy, D Maguire, D McCartan, E W McDermott, R S Prichard, D Winter, D Alazawi, C Barry, T Boyle, W Butt, E M Connolly, N Donlon, C Donohue, B A Fahey, R Farrell, C Fitzgerald, J Kinsella, J O Larkin, P Lennon, P J Maguire, P Mccormick, B J Mehigan, H Mohan, T Nugent, H O'Sullivan, N Ravi, J V Reynolds, A Rogers, P Shokuhi, J Smith, L A Smith, C Timon, Y Bashir, G Bass, T Connelly, B Creavin, H Earley, J A Elliott, A Gillis, D Kavanagh, P Neary, J O'riordan, I S Reynolds, D Rice, P Ridgway, M Umair, M Whelan, P Carroll, C Collins, K Corless, L Finnegan, A Fowler, A Hogan, M Kerin, A Lowery, P McAnena, K McKevitt, K Nizami, É Ryan, A Samy, J C Coffey, R Cunningham, M Devine, D Nally, C Peirce, S Tormey, N Hardy, P Neary, S O'Malley, M Ryan, S Macina, N M Mariani, E Opocher, A Pisani Ceretti, F Ferrari, F Odicino, E Sartori, C Cotsoglou, S Granieri, F Bianco, A Camillo, M Colledan, S Tornese, M F Zambelli, G Bissolotti, S Fusetti, F Lemma, M V Marino, A Mirabella, G Vaccarella, C Agostini, G Alemanno, I Bartolini, C Bergamini, A Bruscino, C Checcucci, R De Vincenti, A Di Bella, M Fambrini, L Fortuna, G Maltinti, P Muiesan, F Petraglia, P Prosperi, M N Ringressi, M Risaliti, F Sorbi, A Taddei, R Tucci, C Bassi, L Bortolasi, T Campagnaro, L Casetti, M De Pastena, A Esposito, M Fontana, A Guglielmi, L Landoni, G Malleo, G Marchegiani, S Nobile, S Paiella, C Pedrazzani, S Rattizzato, A Ruzzenente, R Salvia, G Turri, M Tuveri, P Bellora, G D'Aloisio, M Ferrari, E Francone, S Gentilli, H Nikaj, M Bianchini, M Chiarugi, F Coccolini, G Di Franco, N Furbetta, D Gianardi, S Guadagni, L Morelli, M Palmeri, D Tartaglia, G Anania, P Carcoforo, M Chiozza, A De Troia, M Koleva Radica, M Portinari, M G Sibilla, A Urbani, N Fabbri, C V Feo, S Gennari, S Parini, E Righini, L Ampollini, L Bellanti, M Bergonzani, G Bertoli, G Bocchialini, G D'Angelo, D Lanfranco, L Musini, T Poli, G P Santoro, A Varazzani, L Aguzzoli, G Borgonovo, C Castro Ruiz, S Coiro, G Falco, V D Mandato, V Mastrofilippo, M T Montella, V Annessi, M Zizzo, U Grossi, S Novello, M Romano, S Rossi, G Zanus, G Esposito, F Frongia, A Pisanu, M Podda, C Belluco, A Lauretta, G Montori, L Moras, M Olivieri, F Bussu, A G Carta, M L Cossu, P Cottu, A Fancellu, C F Feo, G C Ginesu, G Giuliani, M Madonia, T Perra, A Piras, A Porcu, D Rizzo, A M Scanu, A Tedde, M Tedde, P Delrio, D Rega, G Badalamenti, G Campisi, A Cordova, M Franza, G Maniaci, G Rinaldi, F Toia, M Calabrò, F Farnesi, E G Lunghi, A Muratore, N S Pipitone Federico, F Bàmbina, G D'Andrea, P Familiari, V Picotti, G De Palma, G Luglio, G Pagano, F P Tropeano, L Baldari, G A Beltramini, L Boni, E Cassinotti, A Gianni, L Pignataro, S Torretta, C Abatini, M Baia, D Biasoni, G Bogani, P Cadenelli, V Capizzi, Spb Cioffi, D Citterio, L V Comini, M Cosimelli, M Fiore, S Folli, M Gennaro, L Giannini, A Gronchi, M Guaglio, A Macchi, F Martinelli, V Mazzaferro, A Mosca, S Pasquali, C Piazza, F Raspagliesi, L Rolli, R Salvioni, G Sarpietro, C Sarre, L Sorrentino, A Agnes, S Alfieri, F Belia, A Biondi, V Cozza, A D'Amore, D D'Ugo, V De Simone, A Fagotti, G Gasparini, L Gordini, F Litta, C P Lombardi, L Lorenzon, A A Marra, F Marzi, A Moro, A Parello, E Perrone, R Persiani, C Ratto, F Rosa, G Saponaro, G Scambia, O Scrima, G Sganga, R Tudisco, A Belli, V Granata, F Izzo, R Palaia, R Patrone, F M Carrano, M M Carvello, A De Virgilio, F Di Candido, F Ferreli, F Gaino, G Mercante, V Rossi, A Spinelli, G Spriano, D M Donati, T Frisoni, E Palmerini, A Aprile, F Barra, P Batistotti, S Ferrero, P Fregatti, S Scabini, M Sparavigna, E Asti, D Bernardi, L Bonavina, A Lovece, L Adamoli, M Ansarin, S Cenciarelli, F Chu, R De Berardinis, U Fumagalli Romario, F Mastrilli, G Pietrobon, M Tagliabue, E Badellino, A Ferrero, R Massobrio, A De Manzoni Garberini, P Federico, P Maida, E Marra, G Marte, A Petrillo, T Tammaro, A Tufo, M Berselli, G Borroni, E Cocozza, L Conti, M Desio, L Livraghi, V Quintodei, A Rizzi, A Zullo, C Baldi, C Corbellini, G M Sampietro, P Cellerino, E Baldini, P Capelli, L Conti, S M Isolani, M Ribolla, A Bondurri, F Colombo, L Ferrario, C Guerci, A Maffioli, T Armao, M Ballabio, P Bisagni, A Gagliano, M Longhi, M Madonini, P PizziCni, A M Baietti, M Biasini, P Maremonti, F Neri, G M Prucher, S Ricci, F Ruggiero, A G Zarabini, R Barmasse, S Mochet, L Morelli, A Usai, F Bianco, P Incollingo, S Mancini, L Marino Cosentino, A Sagnotta, R Fruscio, T Grassi, L C Nespoli, N Tamini, A Anastasi, B Bartalucci, A Bellacci, G Canonico, L Capezzuoli, C Di Martino, P Ipponi, C Linari, M Montelatici, T Nelli, G Spagni, L Tirloni, A Vitali, E Abate, M Casati, T Casiraghi, L Laface, M Schiavo, A Arminio, A Cotoia, V Lizzi, F Vovola, R Vergari, S D'Ugo, N Depalma, M G Spampinato, P Bartolucci, G Brachini, P Bruzzaniti, A Chiappini, V Chiarella, F Ciccarone, P M Cicerchia, B Cirillo, G De Toma, A Di Bartolomeo, E Fiori, G B Fonsi, G Franco, A Frati, M Giugliano, I Iannone, F La Torre, P Lapolla, C Leonardo, G Marruzzo, S Meneghini, A Mingoli, D Ribuffo, M Salvati, A Santoro, P Sapienza, A K Scafa, L Simonelli, M Zambon, G T Capolupo, F Carannante, M Caricato, G Mascianà, E Mazzotta, A Gattolin, M Migliore, R Rimonda, D Sasia, E Travaglio, M Cervellera, A Gori, L Sartarelli, V Tonini, M Giacometti, S Zonta, A Chessa, A Fiorini, C Norcini, G Colletti, M Confalonieri, A Costanzi, C Frattaruolo, G Mari, M Monteleone, A Bandiera, L Bocciolone, G Bonavina, M Candiani, G Candotti, P De Nardi, F Gagliardi, M Medone, P Mortini, G Negri, P Parise, M Piloni, P Sileri, A Vignali, A Belvedere, P Bernante, P Bertoglio, S Boussedra, E Brunocilla, R Cipriani, G Cisternino, E De Crescenzo, P De Iaco, G Dondi, F Frio, E Jovine, F Mineo Bianchi, J Neri, D Parlanti, A M Perrone, A P Pezzuto, M Pignatti, V Pinto, G Poggioli, M Ravaioli, M Rottoli, R Schiavina, M Serenari, M Serra, P Solli, M Taffurelli, M Tanzanu, M Tesei, T Violante, S Zanotti, F Borghi, D Cianflocca, S Di Maria Grimaldi, D Donati, E Gelarda, P Geretto, G Giraudo, M C Giuffrida, A Marano, S Palagi, L Pellegrino, C Peluso, V Testa, F Agresta, D Prando, M Zese, F Aquila, C Gambacciani, L Lippa, F Pieri, O S Santonocito, G Armatura, G Bertelli, A Frena, P Marinello, F Notte, S Patauner, G Scotton, S F Fulginiti, G Gallo, G Sammarco, G Vescio, P Balercia, L Catarzi, G Consorti, F Di Marzo, T Fontana, H Daiko, M Ishikawa, K Ishiyama, S Iwata, K Kanematsu, Y Kanemitsu, T Kato, A Kawai, E Kobayashi, M Kobayashi Kato, K Moritani, F Nakatani, J Oguma, Y Tanase, M Uno, M Al Abdallah, F Ayasra, Y Ayasra, A Qasem, F J Abu Za'nouneh, T Fahmawee, A Hmedat, A Ibrahim, K Obeidat, S Abdel Al, R Abdel Jalil, M K Abou Chaar, M Al-Masri, H Al-Najjar, F Alawneh, O Alsaraireh, M Elayyan, R Ghanem, I Lataifeh, G Z Alkadeeki, F S Al Maadany, N Aldokali, O Senossi, M T Subhi, D Burgan, E Kamoka, A I Kilani, A Salamah, M Salem, A Shuwayyah, E Abdulwahed, E Alshareea, N Aribi, S Aribi, M Biala, R Ghamgh, M Morgom, Z Aldayri, I Ellojli, A Kredan, S Bradulskis, E Dainius, E Kubiliute, J Kutkevicius, A Parseliunas, A Subocius, D Venskutonis, F Rasoaherinomenjanahary, J B Razafindrahita, L H Samison, E C Ong, K H Hamdan, M R Ibrahim, J A Tan, M R Thanapal, N Amin Sahid, F Hayati, J Jayasilan, R K Sriram, S Subramaniam, A Che Jusoh, A H Hussain, A S Mohamed Sidek, M F Mohd Yunus, J Y Soh, Mpk Wong, A D Zakaria, Z Zakaria, A Fadzli, N Q Fathi, P S Koh, Y T Liew, A C Roslani, C Y Tang, L Y Teoh, W J Wong, A S Yahaya, M R Alvarez, R Arrangoiz, F Cordera, M A De la Rosa Abaroa, A Gómez-Pedraza, R Hernandez, A Maffuz-Aziz, J A Posada, F C Becerra García, A Alfaro-Goldaracena, G A Buerba, R A Castillejos-Molina, C Chan, I Dominguez-Rosado, H Medina-Franco, Má Mercado, M Oropeza-Aguilar, E Peña Gómez Portugal, O E Posadas-Trujillo, F Rodriguez-Covarrubias, N Salgado-Nesme, C Sarre, M Vilatoba, Y Arkha, H Bechri, A El Ouahabi, M Y Oudrhiri, F Derkaoui Hassani, N El Abbadi, L Amrani, Z H Belkhadir, A Benkabbou, O Chakib, B El Ahmadi, Y El Bouazizi, H Essangri, A Ghannam, A M Majbar, R Mohsine, A Souadka, R Hompes, E M Meima-van Praag, Ajm Pronk, S Sharabiany, B Grotenhuis, L Hartveld, S Reijers, W Van Houdt, J Baaij, M Bolster-van Eenennaam, M De Graaff, D Sloothaak, P Van Duijvendijk, L Posma-Bouman, T Derksen, J Franken, S Oosterling, R De Bree, J Konsten, M Van Heinsbergen, L Fidelis, T T Sholadoye, M A Tolani, J Olaogun, I K Egbuchulem, T A Lawal, O Ogundoyin, D I Olulana, L Abdur-Rahman, A Adeyeye, I Aremu, J Bello, O Olasehinde, A Popoola, J Massoud, R Massoud, T M Sorour, A Jamal, A A Kerawala, A S Memon, R Nafees Ahmed, L Rai, B Ayub, N Hassan, R S Martins, P Ramesh, R Sayyed, U Butt, M Kashif, M Kashif, W H Khan, A Qureshi, M Umar, M Waris Farooka, T Wasim, A Ayubi, I Rashid, S H Waqar, G M Falcon, R Robles, R Jocson, C Teh, P Major, M Bobinski, J Kotarski, K Rasoul-Pelinska, C Azevedo, D Machado, F Mendes, X De Sousa, U Fernandes, C Ferreira, G Guidi, C Leal, A Marçal, R Marques, D Martins, A Melo, N Tenreiro, R Vaz Pereira, B Vieira, J I Almeida, T Correia de Sá, Mjma Costa, V Fernandes, I Ferraz, C G Gil, C Lima da Silva, L Lopes, N Machado, J Marialva, M Nunes Coelho, J Pedro, C Pereira, R Reis, A Ribeiro, R Santos, P Saraiva, R Silva, F Tavares, M Teixeira, A C Almeida, M J Amaral, R Andrade, R Athayde Nemésio, D Breda, C Camacho, C Canhoto, M Colino, S Correia, M Costa, J De Barros, A L De Oliveira López, M Duque, S Garrido, P Guerreiro, A Guimarães, A Lázaro, C Lopes, R Martins, O Nogueira, A Oliveira, J M Oliveira, M Rodrigues, A Ruivo, E Santos, M Silva, J Simões, A Valente da Costa, A Almeida, S Cavaleiro, V Devezas, C S Faria, F Jácome, M Magalhães Maia, J Nogueiro, A Pereira, A Pereira-Neves, T Pina-Vaz, H Santos-Sousa, H Silveira, S Vaz, P Vieira, A Gomes da Costa, I Lobo Antunes, J Pinto, A Tojal, N Cardoso, P Cardoso, J C Domingues, P Henriques, M I Manso, G Martins Dos Santos, R Martins, H Morais, R Pereira, T Revez, R Ribeiro, V I Ribeiro, A Soares, S Sousa, J Teixeira, E Amorim, V H Baptista, B Cunha MFDias, A Fazenda, J P Melo Neves, F Policarpo, I I Sampaio da Nóvoa Gomes Miguel, D Veiga, A K Andrade, J P Bandovas, N Borges, A Branquinho, B Chumbinho, J Correia, H Fidalgo, I Figueiredo de Barros, S Frade, J Gomes, J Maciel, S Pina, A Rodrigues, N Silva, I Silveira Nunes, R Sousa, J Ascensão, P Azevedo, B Costeira, C Cunha, R Garrido, H Gomes, I Lourenço, G Mendinhos, P Miranda, A Nobre Pinto, M Peralta Ferreira, J Ribeiro, L Rio Rodrigues, M Sousa Fernandes, J Azevedo, D Galvão, A C Soares, A Vieira, B Vieira, B Patrício, Pmdd Santos, A C Vieira Paiva Lopes, R Cunha, A Faustino, A Freitas, J R Martins ABMendes, R Parreira, J Rosa, M Teves, A Abreu da Silva, M Claro, D Costa Santos, A C Deus, J V Grilo, F Borges, J Corte Real, S Henriques, M J Lima, P Matos Costa, F Brito da Silva, A Caiado, F Fonseca, M Ângelo, J M Baiao, D Martins Jordão, T Vieira Caroço, J Messias, A Millan, I Salgado, P Santos, C Baía, R Canotilho, A M Correia, A P Ferreira Pinto, M Peyroteo, J F Videira, P Escobar, M Maldonado Santiago, R Kassir, F Sauvat, C Bezede, A Chitul, E Ciofic, D Cristian, F Grama, L Pirtea, C Secosan, E Bonci, V Gata, S Titu, O Ginghina, N Iordache, R V Iosifescu, T Garmanova, E Kazachenko, D Markaryan, S Rodimov, P Tsarkov, I Tulina, Y Litvina, A Provozina, M Agapov, E Galliamov, V Kakotkin, V Kubyshkin, А Kamalov, M Alshahrani, F Alsharif, M Eskander, R Al Raddadi, S Majrashi, A Mashat, N Akeel, M Alharthi, M Aljiffry, M Basendowah, A Farsi, M Ghunaim, A Khoja, A Maghrabi, N Malibary, M Nassif, A Nawawi, A Saleem, A Samkari, N Trabulsi, S Al Awwad, M Alghamdi, T Alnumani, M Nasser, A Said Bayazeed, A Alhefdhi, O Almalik, A Alomair, N Alotaibi, F Alresaini, R Alsalamah, S Alsobhi, Z Mahasin, E Othman, S Velagapudi, S Ghedan, R Alharthi, S Awad, M I Sharara, S Abdelrahman, W Althobaiti, H Al Habes, A Alamri, S Alkarak, M Alqannas, M Alyami, M Alzamanan, D Cortés Guiral, A Elawad, O AlAamer, L Alriyees, N Alselaim, A Abdulkareem, A Ajlan, K Akkour, A Al-Habib, K Al-Khayal, A Alatar, A Alburakan, H Alhalal, B Alhassan, N Alhassan, O Alobeed, A Alsaif, F Alsaif, S Alshammari, I Alshaygy, M Barry, A Bin Nasser, T Bin Traiki, A Bokhari, S Elwatidy, H Helmi, A Madkhali, T Nouh, P D Rabah, A Zubaidi, I Paunovic, N Slijepcevic, L Aleksic, A Antic, G Barisic, M Ceranic, D Galun, Ž Grubac, J Jelenkovic, D Kecmanovic, S Kmezic, D Knezevic, Z Krivokapic, S Latincic, V Markovic, S Matic, M Miladinov, M Pavlov, I Pejovic, D Radenkovic, B Tadic, J Vasljevic, D Velickovic, M Zivanovic, M Perovic, L Srbinovic, S Andrijasevic, T Bozanovic, R Cerovic Popovic, M Dokic, T Janjic, K Jeremic, S Kadija, I Ladjevic Likic, L Mirkovic, S Pantovic, I Pilic, M Radojevic, A Stefanovic, S Vidakovic, Z Vilendecic, S Antic, D Dunderovic, D Jelovac, Z Jezdic, V Konstantinovic, B Kotlar, C Kuzmanovic, M Lazic, M Petrovic, F Popovic, A Pucar, M Romic, S Sumrak, V Vujanac, V Bascarevic, I Bogdanovic, D Grujicic, R Ilic, M Milicevic, F Milisavljevic, A Miljkovic, A Paunovic, V Scepanovic, A Stanimirovic, M Todorovic, A Jotic, J Milovanovic, A Trivic, U Bumbasirevic, Z Dzamic, B Kajmakovic, N Prijovic, M Zivkovic, M Buta, A Cvetkovic, I Djurisic, S Gacic, M Goran, Z Inic, N Jeftic, M Jevric, V Jokic, I Markovic, M Milanovic, S Nikolic, L Pejnovic, N Savkovic, I Spurnic, D Stevic, D Stojiljkovic, N Vucic, M Zegarac, A Karamarkovic, M Kenic, B Kovacevic, I Krdzic, V Milutinovic, C W Chan, B Lieske, B Gális, K Šimko, N Almgla, M Bernon, A Boutall, L Cairncross, A Herman, T Hilton, E Jonas, C Kloppers, F Malherbe, W Mugla, D Nel, S Rayamajhi, T Van Wyngaard, J Vogel, A M Castaño-Leon, J Delgado Fernandez, C Eiriz Fernandez, M Espino Segura-Illa, O Esteban Sinovas, D Garcia Perez, P Gomez, L Jimenez-Roldan, A Lagares, L Moreno-Gomez, I Paredes, A Pérez Núñez, G Sánchez Aniceto, M Santas, P Fernández Rodríguez, M Paniagua García Señorans, R Sanchez-Santos, V Vigorita, E Acrich, E Baena Sanfeliu, O Barrios, T Golda, C Santanach, M Serrano-Navidad, M Sorribas Grifell, R V Vives, D Escolà, A Jiménez, L Cayetano Paniagua, L Gómez Fernández, E Artigues, J C Bernal-Sprekelsen, J C Catalá Bauset, P Collera, L Diaz De, R Gobbo, R Farre Font, R Flores Clotet, C J Gómez Díaz, N Guàrdia, C A Guariglia, A Osorio, R Sanchez Jimenez, L Sanchon, C Soto Montesinos, B Albi Martin, J E García Villayzán, L Alonso-Lamberti, M Assaf, N Baeza Pintado, A Carabias, J García-Quijada, M A Huertas Fernandez, J Jimenez Miramón, V Jimenez, J M Jover, S A Landeo AgÜero, R Leon, M B Martín Salamanca, V Pérez Simón, S Ponce, J L Rodriguez, A Salazar, A Valle Rubio, H Aguado, I Aldecoa Ansorregui, R Bravo Infante, F B De Lacy, A Di Somma, B Díaz-Feijoo, J Enseñat Nora, N Fabregas, A Ferrés, B Gil Ibañez, J J Gonzalez Sanchez, I Gracia, J A Hoyos Castro, A M Lacy, C Langdon, D Momblán, X Morales, L Oleaga, A Otero, L Pedrosa, J Poblete Carrizo, L A Reyes Figueroa, P Roldan Ramos, J Rumia-Arboix, A I Tercero-Uribe, T E Topczewski, J Torales, A Torne, R Torné, V Turrado-Rodriguez, R Valero, S Valverde, R Anula, O Cano-Valderrama, M Del Campo Martín, L Díez-Valladares, I Domínguez, J Dziakova, M García Alonso, E García Romero, L Gómez Latorre, J M Muguerza, M J Pizarro, P Saez Carlin, C Sánchez Del Pueblo, A Sánchez-Pernaute, G Sanz Ortega, R Sanz-Lopez, A Torres, M Garcés-Albir, F Lopez, J Martín-Arévalo, D Moro-Valdezate, V Pla-Marti, J Beltrán de Heredia, B De Andrés Asenjo, T Gómez Sanz, C Jezieniecki, H Nuñez Del Barrio, F J Ortiz de Solórzano Aurusa, A Romero de Diego, M Ruiz Soriano, J Trujillo Díaz, A Vazquez Fernandez, P Lora-Cumplido, M V Sosa, E Gonzalez-Gonzalez, A M Minaya Bravo, N Alonso de la Fuente, M Cazador Labat, L Cecchini, C A Espinosa, M Jimenez Toscano, A López Campillo, G Mancebo, P Martorell, M Munarriz, E J Grau-Talens, B Martin-Perez, J A Benavides Buleje, M Carrasco Prats, P V Fernández, A Fernández-López, D García Escudero, V J García Porcel, V Garcia Soria, C Giménez Francés, F M González Valverde, E Gurrea, P López-Morales, A Marco Garrido, J A Martínez Alonso, E Medina, J M Muñoz Camarena, P A Parra Baños, E Peña Ros, M Ramirez Faraco, M Ruiz-Marín, C Sanchez Rodriguez, M Valero Soriano, M Estaire Gómez, Á Fernández Camuñas, E P Garcia Santos, E Jimenez Higuera, C Martínez-Pinedo, V Muñoz-Atienza, D Padilla-Valverde, R Picón Rodríguez, F J Redondo Calvo, S Sánchez-García, D Sanchez-Pelaez, R C Colombari, E Del Valle, M Fernández, P Lozano Lominchar, L Martín, C Rey Valcarcel, M A Steiner, M Tudela, J Zorrilla Ortúzar, F Alcaide Matas, J M García Pérez, P Troncoso Pereira, I Mora-Guzmán, M Abellán, M Achalandabaso Boira, R Jorba, R Memba Ikuga, C Olona, R Sales Mallafré, P Cavallé Busquets, Mgp Gavalda Pellice, J Salinas Peña, E J Aragon Achig, L Barbier, P Caja Vivancos, A Gainza, J J García Gutierrez, G Mallabiabarrena Ormaechea, H Marín, P Martin Playa, I Melchor Corcóstegui, M Prieto Calvo, A Rodriguez Fraga, I Villalabeitia Ateca, U De Andres Olabarria, M Durán Ballesteros, F J Fernández Pablos, F J Ibáãez-Aguirre, A Sanz Larrainzar, B Ugarte-Sierra, Á De la Hoz Rodríguez, M Di Martino, J García Septiem, E Martin-Perez, J L Muñoz de Nova, P Calvo Espino, P Guillamot Ruano, L Colao García, D Díaz Pérez, E Esteban Agustí, P Galindo Jara, M Gutierrez Samaniego, M A Hernandez Bartolome, J Serrano González, A Alonso Poza, B Diéguez, M García-Conde, M Hernández-García, M Losada, C M Chiesa-Estomba, Já González García, E Larruscain, J A Sistiaga-Suárez, E Alvarez, N Chavarrias, L Frías, V García Pineda, A Gegúndez Simón, S Gortázar, M Gracia, J Guevara, A Hernández Gutierrez, A Loayza, D T María Dolores, C Martí, M Melendez, E Moreno-Palacios, Y Perez, M I Prieto Nieto, P Ramos-Martín, I Rubio-Perez, J Saavedra, J I Sanchez-Mendez, J Siegrist Ridruejo, A Urbieta, I Zapardiel, M Cantalejo Diaz, Mdc De Miguel Ardevines, V Duque-Mallén, I Gascon Ferrer, M T González-Nicolás Trébol, C Gracia-Roche, M Herrero Lopez, U M Jariod Ferrer, A Lanzon, A Martinez German, M Matute, C Redondo, N Sánchez Fuentes, M Sánchez-Rubio, M S Santero-Ramirez, S Saudí, M V Simón Sanz, T Uson-Bouthelier, A Blazquez Martin, M Diez Alonso, E García Rico, E Garcia-Loarte Gomez, F Garcia-Moreno Nisa, A Gutierrez Calvo, P Hernandez, I Lasa, F Mendoza-Moreno, N Morales Palacios, E Ovejero Merino, C Vera Mansilla, F Acebes García, M Bailón, A D Bueno Cañones, E Choolani Bhojwani, P Marcos-Santos, T Miguel, D Pacheco Sánchez, B Pérez-Saborido, J Sanchez Gonzalez, F J Tejero-Pintor, F Alconchel, A Conesa, J Gil Martínez, A I Gutiérrez Fernández, A Lopez Abad, T Nicolás-López, P Ramirez Romero, M J Roca Calvo, K Rodrigues, J J Ruiz Manzanera, A I Soriano, A Cano, L Capitan-Morales, J Cintas Catena, J Gomez-Rosado, F Oliva Mompean, M A Pérez Sánchez, F D Río Lafuente, C Torres Arcos, J Valdes-Hernandez, H Cholewa, S Domingo, M Frasson, V Lago, T Marina Martin, C Martínez Chicote, J Sancho-Muriel, A Landaluce-Olavarria, D Lecumberri, A Abad Gurumeta, A Abad-Motos, E Martínez-Hurtado, J Ripollés-Melchor, A Ruiz Escobar, A Cuadrado-García, L Garcia-Sancho Tellez, J Heras Aznar, P Maté, I Ortega Vázquez, A L Picardo, J A Rojo López, F Sanchez Cabezudo Noguera, D Serralta de Colsa, J Anchuelo Latorre, C Cagigas Fernandez, R Caiña Ruiz, M Gomez Ruiz, F Hernanz, J Jimeno Fraile, P Martínez-Pérez, C Poch, S Santarrufina Martinez, V Valbuena Jabares, C Moliner-Sánchez, L Pingarron-Martin, J Rey-Biel, I Ruiz Martin, J L Blas Laina, B Cros, J Escartin, J Garcia Egea, A Nogués, I Talal El-Abur, C Yánez, E P Cagigal Ortega, I Cervera, P Díaz Peña, Gdcr Elena, D Enjuto, P Fernández Bernabé, R Garcés García, J Gonzalez, I Hernández, N Herrera-Merino, M Marqueta De Salas, P Martinez Pascual, M Perez Gonzalez, A Ramos Bonilla, L Rodríguez Gómez, C Bescós, R Blanco-Colino, I Brana, B Caimari, A De Pablo García-Cuenca, F Duran-Valles, E Espin-Basany, J Giralt Lóez de Sagredo, J Pamias, G Pellino, N Prat, R Pujol Pina, M Saez Barba, A Arulanantham, Gbk Bandara, U Jayarajah, S Ravindrakumar, V S Rodrigo, S Srishankar, A A Ali Karar, P Elbe, E K Lindqvist, H Taflin, A Älgå, G Heinius, M Nordberg, E Pieniowski, I Gkekas, N Löfgren, M Rutegård, M Sund, M Arigoni, M Bernasconi, D Christoforidis, M Di Giuseppe, D La Regina, F Mongelli, M Chevallay, O Dwidar, E Gialamas, M Sauvain, F Klenke, A Kollàr, C Kurze, M Adamina, T Bächler, A S Crugnale, M Giardini, L Guglielmetti, G Peros, F Solimene, A Aghayeva, I Hamzaoglu, I Sahin, E Akaydin, Z Aliyeva, E Aytac, B Baca, O DÜlgeroğlu, V Ozben, B B Ozmen, C Uras, A E Arikan, I A Bilgin, B Bozkirli, G O Ceyhan, H Kara, T Karahasanoglu, C Uras, H Celik, M M Meydanli, H Akilli, A Ayhan, E Kuscu, M A Onan, U Akgor, H A Dincer, T Erol, M Gultekin, N Orhan, N Ozgul, M C Salman, B Soyak, A Alhamed, S ErgÜn, M F OZcelik, A N Sanli, S S Uludag, M Velidedeoglu, A K Zengin, M A Bozkurt, Y Kara, A Kocatas, B Cimenoglu, R Demirhan, K Saracoglu, I F Azamat, E Balik, D Bugra, B Giray, C B Kulle, C Taskiran, D Vatansever, K Gözal, S A GÜler, H Köken, O C Tatar, N Z Utkan, A Yildirim, E YÜksel, E Akin, F Altintoprak, Z Bayhan, G Cakmak, R Çapoglu, F Çelebi, H Demir, E Dikicier, N Firat, E GönÜllÜ, M B Kamburoglu, B Kocer, I F KÜçÜk, B Mantoglu, E Çolak, G O Kucuk, M S Uyanik, B Göksoy, E Bozkurt, B Citgez, M Mihmanli, M Tanal, G Yetkin, M Akalin, C Arican, E K Avci, C Aydin, S Demirli Atici, M Emiroglu, T Kaya, E Kebabçi, G Kilinc, Y Kirmizi, H Ogucu, S Salimoglu, I Sert, C Tugmen, K Tuncer, G Uslu, D Yesilyurt, E Karaman, A Kolusari, A Yildiz, O Benson, H Lule, J Agilinko, A Ahmeidat, M Barabasz, M Bekheit, L K Cheung, T Colloc, W Cymes, M Elhusseini, G Gradinariu, A Hannah, B S Kamera, G Mignot, S Shaikh, P Sharma, I Abu-Nayla, A Agrawal, A Al-Mohammad, S Ali, J Ashcroft, A Azizi, O Baker, A Balakrishnan, M Byrne, A Colquhoun, A Cotter, P Coughlin, R J Davies, A Durrani, M Elshaer, S Fordington, P Forouhi, F Georgiades, H Grimes, A Habeeb, V Hudson, P Hutchinson, E Irune, A Jah, D Z Khan, A Kolias, H Kyriacou, B Lamb, S Liau, L Luke, R Mahmoud, R Mannion, L Masterson, C G Mitrofan, M Mohan, A Morris, S Murphy, R O'Neill, S Price, J Pushpa-Rajah, W Raby-Smith, J Ramzi, S Rooney, T Santarius, A Singh, G D Stewart, X S Tan, A Townson, E Tweedle, C Walker, S Waseem, S Yordanov, T Jones, A Kattakayam, C Loh, R Lunevicius, S Pringle, A Schache, R Shaw, A Sheel, C Rossborough, D Angelou, M Choynowski, B McAree, A McCanny, D Neely, G Tutoveanu, S Ahad, Mfi De La Cruz Monroy, F Mosley, V Oktseloglou, A Alanbuki, M Patel, A Shabana, E Perera, D Raveendran, K Ravi-Shankar, J Thiruchelvam, L Arrowsmith, W Campbell, T Grove, C Kontovounisios, O Warren, P Rolland, A Aggarwal, S Brown, C Jelley, N Neal, R Clifford, N Eardley, E Krishnan, N Manu, E Martin, S Roy Mahapatra, O L Serevina, C Smith, D Vimalachandran, M Bordenave, R Houston, G Putnam, A Robson, H Tustin, K Emslie, P L Labib, A Marchbank, D Miller, G Minto, J Natale, H Nwinee, P Panahi, L Rogers, A Abubakar, M M Akhter Rahman, E Chan, Kyk Ko, H O'Brien, K Sasapu, H Woodun, R Inglis, H J Ng, A De Gea Rico, N Ghazali, J Lambert, G Markose, S Math, I Sarantitis, D Shrestha, A Sultana, M Taggarsi, S Timbrell, O P Vaz, L Vitone, A Day, H Dent, M Fahim, S Waheed, A Hunt, N Laskar, A Gupta, J Steinke, S Thrumurthy, E Massie, K McGivern, D Rutherford, M Wilson, J Hardie, S Kazzaz, S Handa, M Kaushal, A Kler, P Patel, J Redfern, S Tezas, Y Aawsaj, S Amonkar, C Barry, L Blackwell, D Blake, J Carter, H Emerson, A Fisher, M Katory, P Korompelis, W McCormick, A Mustafa, L Pearce, N Ratnavelu, R Reehal, L Kretzmer, L Lalou, B Manku, I Parwaiz, J Stafford, M Abdelkarim, A Asqalan, T Gala, S Ibrahim, A Maw, R Mithany, R Morgan, G Sundaram Venkatesan, K Ang, E J Caruana, M F Chowdhry, A Mohammad, A Nakas, S Rathinam, M Boal, O Brown, S Dwerryhouse, S Higgs, A Vallance, E Boyd, V Irvine, A Kirk, G Bakolas, A Boulton, A Chandock, T Khan, M Kumar, P Agoston, A Bille, B Challacombe, S Fraser, K Harrison-Phipps, J King, G Mehra, L Mills, M Najdy, R Nath, L Okiror, J Pilling, V Rizzo, T Routledge, A Sayasneh, L Stroman, A Wali, M Fehervari, C Fotopoulou, N Habib, S Hamrang-Yousefi, Z Jawad, L Jiao, M Pai, J Ploski, P Rajagopal, S Saso, M Sodergren, D Spalding, S Laws, C Hardie, C McNaught, R Alam, A Budacan, J Cahill, M Kalkat, S Karandikar, L Kenyon, D Naumann, A Patel, J Ayorinde, T Chase, T Cuming, A Ghanbari, L Humphreys, S Tayeh, A Aboelkassem Ibrahim, R Bichoo, H Cao, Akw Chai, J Choudhury, C Evans, H Fitzjohn, H Ikram, M Langstroth, M Loubani, A McMillan, S Nazir, Ssa Qadri, A Robinson, E Ross, T Sehgal, A Wilkins, J Dixon, J Dunning, K Freystaetter, M Jha, S Lester, A Madhavan, S V Thulasiraman, Y Viswanath, T Curl-Roper, C Delimpalta, Ccl Liao, V Velchuru, E Westwood, E Belcher, G Bond-Smith, S Chidambaram, F Di Chiara, K Fasanmade, L Fraser, H Fu, M Ganau, S Gore, J Graystone, D Jeyaretna, H Khatkar, M Lami, M Maher, S Mastoridis, R Mihai, R Piper, S Prabhu, Obf Risk, U Selbong, K Shah, R Smillie, H Soleymani Majd, S Sravanam, D Stavroulias, G D Tebala, M Vatish, C Verberne, K Wallwork, S Winter, M I Bhatti, H Boyd-Carson, E Elsey, E Gemmill, P Herrod, M Jibreel, E Lenzi, T Saafan, D Sapre, T Sian, N Watson, A Athanasiou, G Bourke, L Bradshaw, A Brunelli, J Burke, P Coe, F Costigan, H Elkadi, M Ho, J Johnstone, A Kanatas, V Kantola, A Kaufmann, A Laios, S Lam, E MacInnes, S Munot, C Nahm, M Otify, C Pompili, I Smith, G Theophilou, G Toogood, R Wade, D Ward, C West, S Annamalai, C Ashmore, A Boddy, T Hossain, A Kourdouli, A Gvaramadze, A Jibril, L Prusty, D Thekkinkattil, A Harky, M Shackcloth, A Askari, C Chan, N Cirocchi, S Kudchadkar, K Patel, J Sagar, S Shaw, R Talwar, M Abdalla, R Edmondson, O Ismail, D Jones, K Newton, N Stylianides, A Aderombi, U Andaleeb, O Bajomo, K Beatson, W Garrett, M Mehmood, V Ng, R Al-Habsi, G S Divya, B Keeler, B Al-Sarireh, R Egan, R Harries, A Henry, M Kittur, Z Li, K Parkins, F Soliman, N Spencer, D Thompson, C Burgess, C Gemmell, C Grieco, M Hollyman, L Hunt, J Morrison, S Ojha, N Ryan, F Abbadessa, S Barnard, C Chan, N Dawe, J Hammond, Ali F Mahmoud, I McPherson, C Mellor, J Moir, S Pandanaboyana, J Powell, B Rai, A Rogers, C Roy, A Sachdeva, C Saleh, S Tingle, T Williams, J Manickavasagam, C McDonald, N McGrath, N McSorley, K Ragupathy, L Ramsay, A Solth, O Kakisi, K Seebah, I Shaikh, L Sreedharan, M Youssef, J Shah, P Ameerally, N McLarty, S Mills, A Shenfine, K Sahnan, J Abu, E Addae-Boateng, D Bratt, L Brock, N Burnside, S Cadwell-Sneath, K Gajjar, C Gan, C Grundy, K Hallam, K Hassell, M Hawari, A Joshi, H Khout, K Konstantinidi, Rxn Lee, D Nunns, R Schiemer, T Walton, H Weaver, L Whisker, K Williamson, J McVeigh, R Myatt, M A Williams, R Kaur, E Leung, S Sundar, M Michel, S Patil, S Ravindran, J Sarveswaran, L Scott, M Edmond, E King, M Almond, A Bhangu, O Breik, L D Cato, A Desai, S Ford, E Griffiths, M Idle, M Kamal, A Kisiel, R Kulkarni, Jkc Mak, T Martin, P Nankivell, A Parente, S Parmar, A M Pathanki, L Phelan, P Praveen, S Saeed, N Sharma, J Singh, F Tirotta, D Vijayan, A Geddes, J McCaul, J McMahon, A H Khan, F Khan, A Mansuri, S Mukherjee, M Patel, M Sarigul, S Singh, K L Tan, A Woodham, A Adiamah, H Brewer, A Chowdhury, J Evans, D Humes, J Jackman, A Koh, C Lewis-Lloyd, O Oyende, J Reilly, D Worku, P Cool, G Cribb, K Shepherd, C Bisset, S Moug, N Elson, G Faulkner, P Saleh, C Underwood, G Brixton, L Findlay, T Klatte, A Majkowska, J Manson, R Potter, A Bhalla, Z Chia, P Daliya, A Goyal, E Grimley, A Hamad, A Kumar, F L Malcolm, E Theophilidou, J Bowden, N Campain, I Daniels, C Evans, G Fowler, J John, L Massey, F McDermott, J McGrath, A McLennan, M Ng, J Pascoe, N Rajaretnam, S Bulathsinhala, B Davidson, G Fusai, C Hidalgo Salinas, N Machairas, T Pissanou, J M Pollok, D A Raptis, F Soggiu, H Tzerbinis, S E Xyda, A Beamish, E Davies, R Foulkes, D Magowan, H Nassa, R Ooi, C Price, L Smith, F Solari, A Tang, G Williams, Y Al-Tamimi, A Bacon, N Beasley, D Chew, M Crank, N Ilenkovan, M Macdonald, B Narice, O Rominiyi, A Thompson, I Varley, T Drake, E Harrison, G Linder, J Mayes, R McGregor, R Skipworth, V Zamvar, E Davies, P Hawkin, T Raymond, O Ryska, R Baron, D Dunne, S Gahunia, C Halloran, N Howes, R McKinney, F McNicol, J Russ, P Szatmary, J R Tan, A Thomas, P Whelan, A Anzak, A Banerjee, O Fuwa, F Hughes, J D Jayasinghe, C Knowles, H Kocher, I Leal Silva, F S Ledesma, A Minicozzi, L Navaratne, R Rahman, R Ramamoorthy, C Sohrabi, M Thaha, B Thakur, M Venn, V Yip, R Baumber, J Parry, S Evans, L Jeys, G Morris, M Parry, J Stevenson, N Ahmadi, G Aresu, Z M Barrett-Brown, A S Coonar, H Durio Yates, D Gearon, J Hogan, M King, A Peryt, I S Pradeep, C Smith, M Adishesh, R Atherton, K Baxter, M Brocklehurst, M Chaudhury, N Krishnamohan, J McAleer, G Owens, E Parkin, P Patkar, I Phang, A Aladeojebi, M Ali, B Barmayehvar, A Gaunt, M Gowda, E Halliday, M Kitchen, F Mansour, M Thomas, D Zakai, N Abbassi-Ghadi, H Assalaarachchi, A Currie, M Flavin, A Frampton, M Hague, C Hammer, J Hopper, J Horsnell, S Humphries, A Kamocka, T K Madhuri, S Preston, P Singh, J Stebbing, A Tailor, D Walker, F Aljanadi, M Jones, P Mhandu, C O'Donnell, R Turkington, Z Al-Ishaq, S Bhasin, A S Bodla, A Burahee, A Crichton, R Fossett, N Pigadas, S Pickford, E Rahman, D Snee, R Vidya, N Yassin, F Colombo, D Fountain, M T Hasan, K Karabatsou, R Laurente, O Pathmanaban, A Al-Mukhtar, S Brown, J Edwards, A Giblin, C Kelty, M Lee, G Lye, T Newman, A Sharkey, C Steele, N Sureshkumar Shah, E Whitehall, R Athwal, A Baker, L Jones, C Konstantinou, S Ramcharan, S Singh, J Vatish, R Wilkin, M Ethunandan, G K Sekhon, H Shields, R Singh, F Wensley, S Lawday, A Lyons, T Abbott, S Anwar, K Ghufoor, C Sohrabi, E Chung, R Hagger, A Hainsworth, A Karim, H Owen, A Ramwell, K Williams, C Baker, A Davies, J Gossage, M Kelly, W Knight, J Hall, G Harris, G James, C Kang, D J Lin, A D Rajgor, T Royle, R Scurrah, B Steel, L J Watson, D Choi, R Hutchison, A Jain, V Luoma, H Marcus, R May, A Menon, B Pramodana, L Webber, I A Aneke, P Asaad, B Brown, J Collis, S Duff, A Khan, F Moura, B Wadham, H Warburton, T Elmoslemany, M Jenkinson, C Millward, R Zakaria, S Mccluney, C Parmar, S Shah, J Allison, M S Babar, B Collard, S Goodrum, K Lau, A Patel, R Scott, E Thomas, H Whitmore, D Balasubramaniam, B Jayasankar, S Kapoor, A Ramachandran, A Elhamshary, Smb Imam, K Kapriniotis, V Kasivisvanathan, J Lindsay, S Rakhshani-Moghadam, N Beech, M Chand, L Green, N Kalavrezos, H Kiconco, R McEwen, C Schilling, D Sinha, J Pereca, J Singh, S Chopra, D Egbeare, R Thomas, T Combellack, Sef Jones, M Kornaszewska, M Mohammed, A Sharma, G Tahhan, V Valtzoglou, J Williams, P Eskander, K Gash, L Gourbault, M Hanna, T Maccabe, C Newton, J Olivier, S Rozwadowski, E Teh, D West, H Al-Omishy, M Baig, H Bates, G Di Taranto, K Dickson, N Dunne, C Gill, D Howe, D Jeevan, A Khajuria, K Martin-Ucar AMcEvoy, P Naredla, V Ng, S Robertson, M Sait, D R Sarma, S Shanbhag, T Shortland, S Simmonds, J Skillman, N Tewari, G Walton, M A Akhtar, A Brunt, J McIntyre, K Milne, M M Rashid, A Sgro, K E Stewart, A Turnbull, M Aguilar Gonzalez, S Talukder, C Boyle, D Fernando, K Gallagher, A Laird, D Tham, M Bath, P Patki, C Sohrabi, C Tanabalan, T Arif, C Magee, T Nambirajan, S Powell, R Vinayagam, I Flindall, A Hanson, V Mahendran, S Green, M Lim, L MacDonald, V Miu, L Onos, K Sheridan, R Young, F Alam, O Griffiths, C Houlden, R Jones, V S Kolli, A K Lala, S Leeson, R Peevor, Z Seymour, L Chen, E Henderson, A Loehrer, K Brown, D Fleming, A Haynes, C Heron, C Hill, H Kay, E Leede, K McElhinney, K Olson, E C Osterberg, C Riley, P Srikanth, M Thornhill, D Blazer, G DiLalla, E S Hwang, W Lee, M Lidsky, J Plichta, L Rosenberger, R Scheri, K Shah, K Turnage, J Visgauss, S Zani, J Farma, J Clark, D Kwon, E Etchill, H E Gabre-Kidan AJenny, A Kent, M Ladd, C Long, H Malapati, A Margalit, S Rapaport, J Rose, K Stevens, L Tsai, D Vervoort, P Yesantharao, A Dehal, D Klaristenfeld, K Huynh, L Brown, I Ganly, J Mullinax, N Gusani, J Hazelton, J Maines, J S Oh, A Ssentongo, P Ssentongo, M Azam, A Choudhry, W Marx, J Fleming, A Fuson, J Gigliotti, A Ovaitt, Y Ying, M K Abel, V Andaya, K Bigay, M A Boeck, L Chen, H Chern, C Corvera, I El-Sayed, A Glencer, P Ha, Bcs Hamilton, C Heaton, K Hirose, D M Jablons, K Kirkwood, L Z Kornblith, J R Kratz, R Lee, P N Miller, E Nakakura, B Nunez-Garcia, R O'Donnell, D Ozgediz, P Park, B Robinson, A Sarin, B Sheu, M Varma, K Wai, R Wustrack, M J Xu, D Beswick, J Goddard, J Manor, J Song, T Fullmer, C Gaskill, N Gross, K Kiong, C L Roland, S N Zafar, M Abdallah, A Abouassi, M Almasri, G Kulkarni, H Marwan, M Mehdi, S Aoun, V S Ban, H H Batjer, J Caruso, D Abbott, A Acher, T Aiken, J Barrett, E Foley, P Schwartz, S N Zafar, A Hawkins, A Maiga, J Laufer, S Scasso
- Subjects
Aged, 80 and over ,Male ,Critical Care ,SARS-CoV-2 ,International Cooperation ,COVID-19 ,Middle Aged ,Cohort Studies ,Logistic Models ,Postoperative Complications ,Elective Surgical Procedures ,Neoplasms ,Outcome Assessment, Health Care ,Humans ,Female ,Epidemics ,Aged - Abstract
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
- Published
- 2021
104. An Update on the COGiTATE Phase II Study: Feasibility and Safety of Targeting an Optimal Cerebral Perfusion Pressure as a Patient-Tailored Therapy in Severe Traumatic Brain Injury
- Author
-
Manuel Cabeleira, C. R. van Kaam, Erta Beqiri, David K. Menon, Ari Ercole, D. Bruyninckx, Peter Smielewski, Geert Meyfroidt, Jeanette Tas, Bart Depreitere, Cornelia W. E. Hoedemaekers, Joseph Donnelly, Peter J. Hutchinson, Annalisa Liberti, Gert Bellen, Marta Fedriga, Joanne G. Outtrim, C. Robba, Marcel J.H. Aries, and Marek Czosnyka
- Subjects
Tailored therapy ,Traumatic brain injury ,business.industry ,Phases of clinical research ,Precision medicine ,medicine.disease ,Cerebral autoregulation ,030218 nuclear medicine & medical imaging ,Retrospective data ,03 medical and health sciences ,0302 clinical medicine ,nervous system ,Anesthesia ,medicine ,In patient ,Cerebral perfusion pressure ,business ,030217 neurology & neurosurgery - Abstract
Introduction: Monitoring of cerebral autoregulation (CA) in patients with a traumatic brain injury (TBI) can provide an individual ‘optimal’ cerebral perfusion pressure (CPP) target (CPPopt) at which CA is best preserved. This potentially offers an individualized precision medicine approach. Retrospective data suggest that deviation of CPP from CPPopt is associated with poor outcomes. We are prospectively assessing the feasibility and safety of this approach in the COGiTATE [CPPopt Guided Therapy: Assessment of Target Effectiveness] study. Its primary objective is to demonstrate the feasibility of individualizing CPP at CPPopt in TBI patients. The secondary objectives are to investigate the safety and physiological effects of this strategy.
- Published
- 2021
105. Cerebrovascular Consequences of Elevated Intracranial Pressure After Traumatic Brain Injury
- Author
-
Joseph Donnelly, Peter J. Hutchinson, Andras Czigler, Andrea Lavinio, Marek Czosnyka, Leanne Calviello, Frederick A. Zeiler, and Peter Smielewski
- Subjects
Mean arterial pressure ,medicine.medical_specialty ,business.industry ,Cerebral autoregulation ,Critical closing pressure ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,Cerebral blood flow ,Internal medicine ,Cardiology ,medicine ,Autoregulation ,Cerebral perfusion pressure ,business ,030217 neurology & neurosurgery ,Intracranial pressure - Abstract
We compared various descriptors of cerebral hemodynamics in 517 patients with traumatic brain injury (TBI) who had, on average, elevated (>23 mmHg) or normal (
- Published
- 2021
106. Persistent postconcussive symptoms in children and adolescents with mild traumatic brain injury receiving initial head computed tomography
- Author
-
Lennart Riemann, Daphne C. Voormolen, Katrin Rauen, Klaus Zweckberger, Andreas Unterberg, Alexander Younsi, Cecilia Åkerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Anna Antoni, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Pál Barzó, Romuald Beauvais, Ronny Beer, Bo-Michael Bellander, Antonio Belli, Habib Benali, Maurizio Berardino, Luigi Beretta, Morten Blaabjerg, Peter Bragge, Alexandra Brazinova, Vibeke Brinck, Joanne Brooker, Camilla Brorsson, Andras Buki, Monika Bullinger, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Iris Ceyisakar, Hans Clusmann, Mark Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Amra Čović, Nicola Curry, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Helen Dawes, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Ðula Ðilvesi, Abhishek Dixit, Emma Donoghue, Jens Dreier, Guy-Loup Dulière, Ari Ercole, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Valery L. Feigin, Kelly Foks, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Dashiell Gantner, Guoyi Gao, Pradeep George, Alexandre Ghuysen, Lelde Giga, Ben Glocker, Jagoš Golubovic, Pedro A. Gomez, Johannes Gratz, Benjamin Gravesteijn, Francesca Grossi, Russell L. Gruen, Deepak Gupta, Juanita A. Haagsma, Iain Haitsma, Raimund Helbok, Eirik Helseth, Lindsay Horton, Jilske Huijben, Peter J. Hutchinson, Bram Jacobs, Stefan Jankowski, Mike Jarrett, Ji-yao Jiang, Faye Johnson, Kelly Jones, Mladen Karan, Angelos G. Kolias, Erwin Kompanje, Daniel Kondziella, Evgenios Koraropoulos, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Linda Lanyon, Steven Laureys, Fiona Lecky, Didier Ledoux, Rolf Lefering, Valerie Legrand, Aurelie Lejeune, Leon Levi, Roger Lightfoot, Hester Lingsma, Andrew I. R. Maas, Ana M. Castaño-León, Marc Maegele, Marek Majdan, Alex Manara, Geoffrey Manley, Costanza Martino, Hugues Maréchal, Julia Mattern, Catherine McMahon, Béla Melegh, David Menon, Tomas Menovsky, Ana Mikolic, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Daan Nieboer, József Nyirádi, Otesile Olubukola, Matej Oresic, Fabrizio Ortolano, Aarno Palotie, Paul M. Parizel, Jean-François Payen, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Matti Pirinen, Horia Ples, Suzanne Polinder, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Malinka Rambadagalla, Jonathan Rhodes, Sylvia Richardson, Sophie Richter, Samuli Ripatti, Saulius Rocka, Cecilie Roe, Olav Roise, Jonathan Rosand, Jeffrey V. Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Daniel Rueckert, Martin Rusnák, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Janos Sandor, Nadine Schäfer, Silke Schmidt, Herbert Schoechl, Guus Schoonman, Rico Frederik Schou, Elisabeth Schwendenwein, Charlie Sewalt, Toril Skandsen, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Simon Stanworth, Robert Stevens, William Stewart, Ewout W. Steyerberg, Nino Stocchetti, Nina Sundström, Anneliese Synnot, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Mark Steven Taylor, Braden Te Ao, Olli Tenovuo, Alice Theadom, Matt Thomas, Dick Tibboel, Marjolein Timmers, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Peter Vajkoczy, Shirley Vallance, Egils Valeinis, Zoltán Vámos, Mathieu van der Jagt, Gregory Van der Steen, Joukje van der Naalt, Jeroen T. J. M. van Dijck, Thomas A. van Essen, Wim Van Hecke, Caroline van Heugten, Dominique Van Praag, Thijs Vande Vyvere, Roel P. J. van Wijk, Alessia Vargiolu, Emmanuel Vega, Kimberley Velt, Jan Verheyden, Paul M. Vespa, Anne Vik, Rimantas Vilcinis, Victor Volovici, Nicole von Steinbüchel, Daphne Voormolen, Petar Vulekovic, Kevin K. W. Wang, Eveline Wiegers, Guy Williams, Lindsay Wilson, Stefan Winzeck, Stefan Wolf, Zhihui Yang, Peter Ylén, Frederick A. Zeiler, Veronika Zelinkova, Agate Ziverte, Tommaso Zoerle, Riemann, L, Voormolen, D, Rauen, K, Zweckberger, K, Unterberg, A, Younsi, A, Citerio, G, Public Health, Riemann, L., Voormolen, D. C., Rauen, K., Zweckberger, K., Unterberg, A., Younsi A., (CENTER-TBI Investigators and Participants), Beretta, Luigi, University of Zurich, Younsi, Alexander, and Molecular Neuroscience and Ageing Research (MOLAR)
- Subjects
Male ,Pediatrics ,Neurologi ,Health-related quality of life ,Computed tomography ,law.invention ,0302 clinical medicine ,Quality of life ,law ,Prevalence ,Child ,Pediatric ,medicine.diagnostic_test ,Post-Concussion Syndrome ,11359 Institute for Regenerative Medicine (IREM) ,General Medicine ,Rivermead post-concussion symptoms questionnaire ,Intensive care unit ,2746 Surgery ,health-related quality of life ,HRQOL ,2728 Neurology (clinical) ,trauma ,Post concussion ,Neurology ,Postconcussive symptom ,Child, Preschool ,030220 oncology & carcinogenesis ,CT imaging ,Postconcussive symptoms ,Female ,medicine.medical_specialty ,Adolescent ,Traumatic brain injury ,610 Medicine & health ,Neuroimaging ,Trauma ,RPQ ,Young Adult ,03 medical and health sciences ,mild traumatic brain injury ,medicine ,Humans ,In patient ,2735 Pediatrics, Perinatology and Child Health ,Mild traumatic brain injury ,Brain Concussion ,business.industry ,postconcussive symptoms ,Glasgow Coma Scale ,medicine.disease ,pediatric ,Quality of Life ,Rivermead Post Concussion Symptoms Questionnaire ,Tomography, X-Ray Computed ,business ,030217 neurology & neurosurgery - Abstract
OBJECTIVE: The aim of this paper was to evaluate the prevalence of postconcussive symptoms and their relation to health-related quality of life (HRQOL) in pediatric and adolescent patients with mild traumatic brain injury (mTBI) who received head CT imaging during initial assessment. METHODS: Patients aged between 5 and 21 years with mTBI (Glasgow Coma Scale scores 13-15) and available Rivermead Post Concussion Questionnaire (RPQ) at 6 months of follow-up in the multicenter, prospectively collected CENTER-TBI (Collaborative European NeuroTrauma Effectiveness Research in TBI) study were included. The prevalence of postconcussive symptoms was assessed, and the occurrence of postconcussive syndrome (PSC) based on the ICD-10 criteria, was analyzed. HRQOL was compared in patients with and without PCS using the Quality of Life after Brain Injury (QOLIBRI) questionnaire. RESULTS: A total of 196 adolescent or pediatric mTBI patients requiring head CT imaging were included. High-energy trauma was prevalent in more than half of cases (54%), abnormalities on head CT scans were detected in 41%, and admission to the regular ward or intensive care unit was necessary in 78%. Six months postinjury, 36% of included patients had experienced at least one moderate or severe symptom on the RPQ. PCS was present in 13% of adolescents and children when considering symptoms of at least moderate severity, and those patients had significantly lower QOLIBRI total scores, indicating lower HRQOL, compared with young patients without PCS (57 vs 83 points, p < 0.001). CONCLUSIONS: Adolescent and pediatric mTBI patients requiring head CT imaging show signs of increased trauma severity. Postconcussive symptoms are present in up to one-third of those patients, and PCS can be diagnosed in 13% 6 months after injury. Moreover, PCS is significantly associated with decreased HRQOL., Funding Agencies: OneMind (USA) Hannelore Kohl Stiftung (Germany)
- Published
- 2021
107. Single Center Experience in Cerebrospinal Fluid Dynamics Testing
- Author
-
Peter J. Hutchinson, Eva Nabbanja, Eric A. Schmidt, Nicole C Keong, Piotr Smielewski, Gianpaolo Petrella, Slawomir Barszcz, Magda Kasprowicz, Shahan Momjian, Brian Owler, John D. Pickard, Afroditi D Lalou, Zofia Czosnyka, Marek Czosnyka, and Matthew R. Garnett
- Subjects
business.industry ,medicine.disease ,Single Center ,030218 nuclear medicine & medical imaging ,Shunt (medical) ,Hydrocephalus ,Shunting ,03 medical and health sciences ,0302 clinical medicine ,Cerebrospinal fluid ,Cerebral blood flow ,Normal pressure hydrocephalus ,Anesthesia ,medicine ,Autoregulation ,business ,030217 neurology & neurosurgery - Abstract
Normal pressure hydrocephalus is more complex than a simple disturbance of the cerebrospinal fluid (CSF) circulation. Nevertheless, an assessment of CSF dynamics is key to making decisions about shunt insertion, shunt malfunction, and for further management if a patient fails to improve. We summarize our 25 years of single center experience in CSF dynamics assessment using pressure measurement and analysis. 4473 computerized infusion tests have been performed. We have shown that CSF infusion studies are safe, with incidence of infection at less than 1%. Raised resistance to CSF outflow positively correlates (p < 0.014) with improvement after shunting and is associated with disturbance of cerebral blood flow and its autoregulation (p < 0.02). CSF infusion studies are valuable in assessing possible shunt malfunction in vivo and for avoiding unnecessary revisions. Infusion tests are safe and provide useful information for clinical decision-making for the management of patients suffering from hydrocephalus.
- Published
- 2021
108. A concussion education programme for motorsport drivers:A field-based exploratory pilot study
- Author
-
John Sproule, Peter J. Hutchinson, Anthony P. Turner, Stephanie A. Adams, and Hugh Richards
- Subjects
Adult ,Gerontology ,Health Knowledge, Attitudes, Practice ,knowledge ,Adolescent ,Neuroscience (miscellaneous) ,Exploratory research ,Poison control ,Pilot Projects ,Suicide prevention ,Occupational safety and health ,Young Adult ,Surveys and Questionnaires ,Injury prevention ,Concussion ,Developmental and Educational Psychology ,health education ,Humans ,Medicine ,Brain Concussion ,attitudes ,business.industry ,traumatic brain injury ,Human factors and ergonomics ,need for cognition ,medicine.disease ,Athletic Injuries ,Health education ,Neurology (clinical) ,business - Abstract
Objective: Concussion education strategies that improve knowledge and attitudes long term are needed. This exploratory study piloted an interactive concussion education program, adopting concepts from the learning sciences and attitude change literature, for the underserved and high-risk population of motorsports.Method: Forty UK motorsport drivers (ages 16-20 years) participated. The workshop group received a two-phased workshop-based program. The comparison group received a concussion leaflet. Participants completed an adapted version of the Rosenbaum Concussion Knowledge and Attitudes Survey (RoCKAS-ST) at pre-, post- and 2-month follow-up. Within-group analysis for the workshop group explored the differential effect of the individual difference variable, Need for Cognition (NfC), and effectiveness was explored through post-workshop questionnaires and interviews.Results: Unlike the comparison group, the workshop group showed a significant improvement in knowledge over time (F(2,58) = 45.49, p < .001, η2p = .61). Qualitative data indicated workshop-program participants developed safer attitudes toward concussion following programming. Preliminary evidence suggested individuals' responses to concussion education aligned with differences in NfC.Conclusion: This study piloted the first concussion education program for motorsport drivers and explored whether aligning educational provision with the NfC construct may help to improve program effectiveness. Findings are relevant to addressing the public health issue of concussion through educational approaches.
- Published
- 2021
109. External Hydrocephalus After Traumatic Brain Injury: Retrospective Study of 102 Patients
- Author
-
Angelos G. Kolias, Peter Smielewski, Marek Czosnyka, Romain Manet, Peter J. Hutchinson, Afroditi-Despina Lalou, Zofia Czosnyka, and Laurent Gergelé
- Subjects
medicine.medical_specialty ,External hydrocephalus ,Traumatic brain injury ,business.industry ,Large population ,Retrospective cohort study ,medicine.disease ,nervous system diseases ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Subdural hygroma ,Concomitant ,Anesthesia ,Epidemiology ,medicine ,Subarachnoid space ,business ,030217 neurology & neurosurgery - Abstract
Introduction: External hydrocephalus (EH) refers to impairment of extra-axial cerebrospinal fluid flow with enlargement of the subarachnoid space (SAS) and concomitant raised intracranial pressure (ICP). It is often confused with a subdural hygroma and overlooked, particularly when there is no ventricular enlargement. In this study, we aimed to describe the epidemiology of EH in a large population of adults with traumatic brain injury (TBI).
- Published
- 2021
110. Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations
- Author
-
J. Russell Huie, Stefania Mondello, Christopher J. Lindsell, Luca Antiga, Esther L. Yuh, Elisa R. Zanier, Serge Masson, Bedda L. Rosario, Adam R. Ferguson, Opeolu Adeoye, Neeraj Badjatia, Kim Boase, Yelena Bodien, M. Ross Bullock, Randall Chesnut, John D. Corrigan, Karen Crawford, Ramon Diaz-Arrastia, Sureyya Dikmen, Ann-Christine Duhaime, Richard Ellenbogen, V. Ramana Feeser, Brandon Foreman, Raquel Gardner, Etienne Gaudette, Joseph Giacino, Dana Goldman, Luis Gonzalez, Shankar Gopinath, Rao Gullapalli, J. Claude Hemphill, Gillian Hotz, Sonia Jain, Frederick Korley, Joel Kramer, Natalie Kreitzer, Harvey Levin, Joan Machamer, Christopher Madden, Geoffrey T. Manley, Alastair Martin, Thomas McAllister, Michael McCrea, Randall Merchant, Pratik Mukherjee, Lindsay Nelson, Laura B. Ngwenya, Florence Noel, David Okonkwo, Daniel Perl, Ava Puccio, Miri Rabinowitz, Claudia Robertson, Jonathan Rosand, Angelle Sander, David Schnyer, Seth Seabury, Murray Stein, Sabrina Taylor, Nancy Temkin, Arthur Toga, Alex Valadka, Mary Vassar, Paul Vespa, Kevin Wang, John K. Yue, Ross Zafonte, Cecilia Ackerlund, Hadie Adams, Vanni Agnoletti, Judith Allanson, Krisztina Amrein, Norberto Andaluz, Nada Andelic, Lasse Andreassen, Audny Anke, Azasevac Antun, Anna Antoni, Hilko Ardon, Kaspars Auslands, Philippe Azouvi, Maria Luisa Azzolini, Camelia Baciu, Rafael Badenes, Ronald Bartels, Pál Barzó, Ursula Bauerfeind, Romuald Beauvais, Ronny Beer, Francisco Javier Belda, Bo Michael Bellander, Antonio Belli, Rémy Bellier, Habib Benali, Thierry Benard, Maurizio Berardino, Luigi Beretta, Christopher Beynon, Federico Bilotta, Harald Binder, Erta Biqiri, Morten Blaabjerg, Hugo den Boogert, Peter Bragge, Alexandra Brazinova, Vibeke Brinck, Joanne Brooker, Camilla Brorsson, Andras Buki, Monika Bullinger, Manuel Cabeleira, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Lozano Guillermo Carbayo, Marco Carbonara, Elsa Carise, K. Carpenter, Ana M. Castaño León, Francesco Causin, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Maryse Cnossen, Mark Coburn, Jonathan Coles, Lizzie Coles-Kemp, Johnny Collett, Jamie D. Cooper, Marta Correia, Amra Covic, Nicola Curry, Endre Czeiter, Marek Czosnyka, Claire Dahyot Fizelier, François Damas, Pierre Damas, Helen Dawes, Véronique De Keyser, Francesco Della Corte, Bart Depreitere, Godard C.W. de Ruiter, Dula Dilvesi, Shenghao Ding, Diederik Dippel, Abhishek Dixit, Emma Donoghue, Jens Dreier, Guy Loup Dulière, Heiko Engemann, Ari Ercole, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Valery L. Feigin, Junfeng Feng, Kelly Foks, Francesca Fossi, Gilles Francony, Ulderico Freo, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Dashiell Gantner, Guoyi Gao, Karin Geleijns, Pradeep George, Alexandre Ghuysen, Lelde Giga, Benoit Giraud, Ben Glocker, Jagos Golubovic, Pedro A. Gomez, Benjamin Gravesteijn, Francesca Grossi, Russell L. Gruen, Deepak Gupta, Juanita A. Haagsma, Asta Kristine Håberg, Bram Jacobs, Iain Haitsma, Jed A. Hartings, Raimund Helbok, Eirik Helseth, Daniel Hertle, Astrid Hoedemaekers, Stefan Hoefer, Lindsay Horton, Jilske Huijben, Peter J. Hutchinson, Stefan Jankowski, Mike Jarrett, Bojan Jelaca, Ji yao Jiang, Kelly Jones, Konstantinos Kamnitsas, Mladen Karan, Ari Katila, Maija Kaukonen, Thomas Kerforne, Riku Kivisaari, Angelos G. Kolias, Bálint Kolumbán, Erwin Kompanje, Ksenija Kolundzija, Daniel Kondziella, Lars Owe Koskinen, Noémi Kovács, Alfonso Lagares, Linda Lanyon, Steven Laureys, Fiona Lecky, Christian Ledig, Rolf Lefering, Valerie Legrand, Jin Lei, Leon Levi, Roger Lightfoot, Hester Lingsma, Dirk Loeckx, Angels Lozano, Andrew I.R. Maas, Stephen MacDonald, Marc Maegele, Majdan Marek, Sebastian Major, Alex Manara, Geoffrey Manley, Didier Martin, Leon Francisco Martin, Costanza Martino, Hugues Maréchal, Armando Maruenda, Alessandro Masala, Julia Mattern, Charles McFadyen, Catherine McMahon, Béla Melegh, David Menon, Tomas Menovsky, Cristina Morganti Kossmann, Davide Mulazzi, Holger Mühlan, Visakh Muraleedharan, Lynnette Murray, Nandesh Nair, Ancuta Negru, David Nelson, Virginia Newcombe, Daan Nieboer, Quentin Noirhomme, József Nyirádi, Mauro Oddo, Annemarie Oldenbeuving, Matej Oresic, Fabrizio Ortolano, Aarno Palotie, Paul M. Parizel, Adriana Patruno, Jean François Payen, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Floury Sébastien Pili, Matti Pirinen, Horia Ples, Maria Antonia Poca, Suzanne Polinder, Inigo Pomposo, Jussi Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Malinka Rambadagalla, Ruben Real, Veronika Rehorčíková, Jonathan Rhodes, Samuli Ripatti, Saulius Rocka, Cecilie Roe, Olav Roise, Gerwin Roks, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Daniel Rueckert, Martin Rusnák, Marco Sacchi, Barbara Sahakian, Juan Sahuquillo, Oliver Sakowitz, Francesca Sala, Renan Sanchez Porras, Janos Sandor, Edgar Santos, Luminita Sasu, Davide Savo, Nadine Schäffer, Inger Schipper, Barbara Schlößer, Silke Schmidt, Herbert Schoechl, Guus Schoonman, Rico Frederik Schou, Elisabeth Schwendenwein, Michael Schöll, Charlie Sewalt, Özcan Sir, Toril Skandsen, Lidwien Smakman, Dirk Smeets, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Simon Stanworth, Nicole Steinbüchel, Ana Stevanovic, Robert Stevens, William Stewart, Ewout W. Steyerberg, Nino Stocchetti, Nina Sundström, Anneliese Synnot, Fabio Silvio Taccone, Riikka Takala, Viktória Tamás, Päivi Tanskanen, Mark Steven Taylor, Braden Te Ao, Olli Tenovuo, Ralph Telgmann, Guido Teodorani, Alice Theadom, Matt Thomas, Dick Tibboel, Christos Tolias, Jean Flory Luaba Tshibanda, Tony Trapani, Cristina Maria Tudora, Peter Vajkoczy, Shirley Vallance, Egils Valeinis, Gregory Van der Steen, Mathieu van der Jagt, JV de Naalt, Jeroen T.J.M. van Dijck, Thomas A. van Essen, Wim Van Hecke, Caroline van Heugten, Dominique Van Praag, Thijs Vande Vyvere, Julia Van Waesberghe, Audrey Vanhaudenhuyse, Alessia Vargiolu, Emmanuel Vega, Kimberley Velt, Jan Verheyden, Paul M. Vespa, Anne Vik, Rimantas Vilcinis, Giacinta Vizzino, Carmen Vleggeert Lankamp, Victor Volovici, Daphne Voormolen, Peter Vulekovic, Zoltán Vámos, Derick Wade, Kevin K.W. Wang, Lei Wang, Lars Wessels, Eveline Wiegers, Eno Wildschut, Guy Williams, Lindsay Wilson, Maren K.L. Winkler, Stefan Wolf, Peter Ylén, Alexander Younsi, Menashe Zaaroor, Frederik Zeiler, Yang Zhihui, Agate Ziverte, Fabrizio Zumbo, Huie, J Russell, Mondello, Stefania, Lindsell, Christopher J, Antiga, Luca, Yuh, Esther L, Zanier, Elisa R, Masson, Serge, Rosario, Bedda L, Ferguson, Adam R (Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Participants and Investigators), Beretta, Luigi, Huie, J, Mondello, S, Lindsell, C, Antiga, L, Yuh, E, Zanier, E, Masson, S, Rosario, B, Ferguson, A, Citerio, G, and Molecular Neuroscience and Ageing Research (MOLAR)
- Subjects
Traumatic ,030506 rehabilitation ,Data Interpretation ,Data management ,data sharing ,TERMINAL HYDROLASE-L1 ,Big data ,Poison control ,0302 clinical medicine ,Brain Injuries, Traumatic ,TBI ,Medicine ,Biomarker discovery ,Common Data Elements ,traumatic brain injury ,Injuries and accidents ,Statistical ,Reference Standards ,NET RECLASSIFICATION INDEX ,Data Interpretation, Statistical ,Biomarker (medicine) ,biomarker ,0305 other medical science ,Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators ,CT ,The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators ,medicine.medical_specialty ,Physical Injury - Accidents and Adverse Effects ,Clinical Sciences ,Context (language use) ,Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0] ,Traumatic Brain Injury (TBI) ,Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Participants and Investigators ,03 medical and health sciences ,MICROARRAY ,Special Section: Statistical Methods in Tbi Research ,Humans ,biomarkers ,Intensive care medicine ,Traumatic Head and Spine Injury ,Neurology & Neurosurgery ,business.industry ,Information Dissemination ,OUTCOME PREDICTION ,Neurosciences ,COMMON DATA ELEMENTS ,Precision medicine ,Brain Disorders ,DIFFUSE AXONAL INJURY ,Data sharing ,Good Health and Well Being ,Brain Injuries ,DISCOVERY ,TRACK ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Contains fulltext : 238746.pdf (Publisher’s version ) (Closed access) Recent biomarker innovations hold potential for transforming diagnosis, prognostic modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many biomarkers, including brain imaging, genomics, and proteomics, involve vast quantities of high-throughput and high-content data. Management, curation, analysis, and evidence synthesis of these data are not trivial tasks. In this review, we discuss data management concepts and statistical and data sharing strategies when dealing with biomarker data in the context of TBI research. We propose that application of biomarkers involves three distinct steps-discovery, evaluation, and evidence synthesis. First, complex/big data has to be reduced to useful data elements at the stage of biomarker discovery. Second, inferential statistical approaches must be applied to these biomarker data elements for assessment of biomarker clinical utility and validity. Last, synthesis of relevant research is required to support practice guidelines and enable health decisions informed by the highest quality, up-to-date evidence available. We focus our discussion around recent experiences from the International Traumatic Brain Injury Research (InTBIR) initiative, with a specific focus on four major clinical projects (Transforming Research and Clinical Knowledge in TBI, Collaborative European NeuroTrauma Effectiveness Research in TBI, Collaborative Research on Acute Traumatic Brain Injury in Intensive Care Medicine in Europe, and Approaches and Decisions in Acute Pediatric TBI Trial), which are currently enrolling subjects in North America and Europe. We discuss common data elements, data collection efforts, data-sharing opportunities, and challenges, as well as examine the statistical techniques required to realize successful adoption and use of biomarkers in the clinic as a foundation for precision medicine in TBI.
- Published
- 2021
111. Analysis of the Association Between Lung Function and Brain Tissue Oxygen Tension in Severe Traumatic Brain Injury
- Author
-
Rafael Badenes, Joseph Donnelly, Peter J. Hutchinson, Arun K. Gupta, Erta Beqiri, Chiara Robba, Shadnaz Asgari, Amit Gupta, Mypinder S. Sekhon, and Paolo Pelosi
- Subjects
medicine.medical_specialty ,business.industry ,Traumatic brain injury ,Haemoglobin levels ,Brain tissue ,Oxygenation ,medicine.disease ,Independent factor ,030218 nuclear medicine & medical imaging ,Oxygen tension ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Cardiology ,Cerebral perfusion pressure ,business ,030217 neurology & neurosurgery ,Lung function - Abstract
Introduction: Low brain tissue oxygen tension (PbtO2) has been shown to be an independent factor associated with unfavourable outcomes in traumatic brain injury (TBI). Although PbtO2 provides clinicians with an understanding of ischaemic and non-ischaemic derangements of brain physiology, the value alone can be the result of several factors, including partial arterial oxygenation pressure (PaO2), haemoglobin levels (Hb) and cerebral perfusion pressure (CPP).
- Published
- 2021
112. Decompressive Craniectomy in the Management of Traumatic Brain Injury
- Author
-
Peter J. Hutchinson, Angelos G. Kolias, and Sara Venturini
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Traumatic brain injury ,business.industry ,medicine.medical_treatment ,medicine ,Decompressive craniectomy ,medicine.disease ,business ,humanities ,Surgery - Abstract
This chapter aims to summarise the current evidence on the role of decompressive craniectomy (DC) in the management of patients suffering from traumatic brain injury (TBI).
- Published
- 2021
113. Elective Cancer Surgery in COVID-19-Free Surgical Pathways during the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
- Author
-
Writing Group (denotes joint first author) James, C Glasbey (UK), Dmitri Nepogodiev (UK), Joana FF Simoes (Portugal), Omar Omar (UK), Elizabeth Li (UK), Mary, L Venn (UK), Mohammad Abou Chaar (Jordan), Vita Capizzi (Italy), Daoud Chaudhry (UK), Anant Desai (UK), Jonathan, G Edwards (UK), Jonathan, P Evans (UK), Marco Fiore (Italy), Jose Flavio Videria (Portugal), Samuel, J Ford (UK), Ian Ganyli (USA), Ewen, A Griffiths (UK), Rohan, R Gujjuri (UK), Angelos, G Kolias (UK), Haytham MA Kaafarani (USA), Ana Minaya-Bravo (Spain), Siobhan, C McKay (UK), Helen, M Mohan (Ireland), Keith Roberts (UK), Carlos San Miguel-Mé, ndez (Spain), Peter Pockney (Australia), Richard Shaw (UK), Neil, J Smart (UK), Grant, D Stewart (UK), Sudha Sundar (UK), Raghavan Vidya (UK), Aneel, A Bhangu (UK, Statistical analysis Glasbey JC, Overall guarantor)., Omar, O (Lead statistician), Bhangu, A CovidSurg Operations Committee Kwabena Siaw-Acheampong, Ruth, A Benson, Edward, Bywater, Daoud, Chaudhry, Brett, E Dawson, Jonathan, P Evans, James, C Glasbey, Rohan, R Gujjuri, Emily, Heritage, Conor, S Jones, Sivesh, K Kamarajah, Chetan, Khatri, Rachel, A Khaw, James, M Keatley, Andrew, Knight, Samuel, Lawday, Elizabeth, Li, Harvinder, S Mann, Ella, J Marson, Kenneth, A McLean, Siobhan, C Mckay, Emily, C Mills, Dmitri, Nepogodiev, Gianluca, Pellino, Maria, Picciochi, Elliott, H Taylor, Abhinav, Tiwari, Joana FF Simoes, Isobel, M Trout, Mary, L Venn, Richard JW Wilkin, International Cancer Leads (denotes specialty Principal Investigators) James C Glasbey (Chair), Aneel Bhangu., Colorectal: Neil, J Smart, Ana, Minaya-Bravo, Susan, Moug, Dale, Vimalchandran, Abigail, Vallance, Peter, Pockney, Oesophagogastric: Ewen, A Griffiths, Richard PT Evans, Philip, Townend, Hepatopancreatobilary: Keith Roberts, Siobhan, McKay, John, Isaac, Sohei, Satoi, Thoracic: John Edwards, Aman, S Coonar, Adrian, Marchbank, Edward, J Caruana, Georgia, R Layton, Akshay, Patel, Alessandro, Brunelli, Sarcoma: Samuel Ford, Anant, Desai, Alessandro, Gronchi, Marco, Fiore, Max, Almond, Fabio, Tirotta, Sinziana, Dumitra, Neurosurgery: Angelos Kolias, Stephen, J Price, Daniel, M Fountain, Michael, D Jenkinson, Peter, Hutchinson, Hani, J Marcus, Rory, J Piper, Laura, Lippa, Franco, Servadei, Ignatius, Esene, Christian, Freyschlag, Iuri, Neville, Gail, Rosseau, Karl, Schaller, Andreas, K Demetriades, Faith, Robertson, Alex, Alamri, Head and neck: Richard Shaw, Andrew, G Schache, Stuart, C Winter, Michael, Ho, Paul, Nankivell, Juan Rey Biel, Martin, Batstone, Ian, Ganly, Breast: Raghavan Vidya, Alex, Wilkins, Jagdeep, K Singh, Dinesh, Thekinkattil, Gynaecology: Sudha Sundar, Christina, Fotopoulou, Elaine, Leung, Tabassum, Khan, Luis, Chiva, Jalid, Sehouli, Anna, Fagotti, Paul, Cohen, Murat, Gutelkin, Rahel, Ghebre, Thomas, Konney, Rene, Pareja, Rob, Bristow, Sean, Dowdy, Shylasree TS Rajkumar, Joe, Ng, Keiiji, Fujiwara, Urology: Grant, D Stewart, Benjamin, Lamb, Krishna, Narahari, Alan, McNeill, Alexandra, Colquhoun, John, McGrath, Steve, Bromage, Ravi, Barod, Veeru, Kasivisvanathan, Dissemination Committee Joana FF Simoes (Chair), Tobias Klatte., Tom EF Abbott, Michel, Adamina, Adesoji, O Ademuyiwa, Arnav, Agarwal, Ehab, Alameer, Derek, Alderson, Felix, Alakaloko, Markus, Albertsmeiers, Osaid, Alser, Muhammad, Alshaar, Sattar, Alshryda, Alexis, P Arnaud, Knut Magne Augestad, Faris, Ayasra, José, Azevedo, Brittany, K Bankhead-Kendall, Emma, Barlow, Ruth, Blanco-Colino, Amanpreet, Brar, Kerry, A Breen, Chris, Bretherton, Igor Lima Buarque, Joshua, Burke, Mohammad, Chaar, Sohini, Chakrabortee, Peter, Christensen, Daniel, Cox, Moises, Cukier, Miguel, F Cunha, Giana, H Davidson, Salomone Di Saverio, Thomas, M Drake, John, G Edwards, Muhammed, Elhadi, Sameh, Emile, Shebani, Farik, J Edward Fitzgerald, Samuel, Ford, Tatiana, Garmanova, Gaetano, Gallo, Dhruv, Ghosh, Gustavo Mendonç, a Ataí, de Gomes, Gustavo, Grecinos, Ewen, A Griffiths, Madalegna, Grü, ndl, Constantine, Halkias, Ewen, M Harrison, Intisar, Hisham, Peter, J Hutchinson, Shelley, Hwang, Arda, Isik, Pascal, Jonker, Haytham MA Kaafarani, Angelos, Kolias, Schelto, Kruijff, Ismail, Lawani, Hans, Lederhuber, Sezai, Leventoglu, Andrey, Litvin, Andrew, Loehrer, Markus, W Lö, ffler, Maria Aguilera Lorena, Maria Marta Madolo, Piotr, Major, Janet, Martin, Hassan, N Mashbari, Dennis, Mazingi, Symeon, Metallidis, Helen, M Mohan, Rachel, Moore, David, Moszkowicz, Joshua, S Ng-Kamstra, Mayaba, Maimbo, Milagros, Niquen, Faustin, Ntirenganya, Maricarmen, Olivos, Kacimi, Oussama, Oumaima, Outani, Marie Dione Parreno-Sacdalanm, Francesco, Pata, Carlos Jose Perez Rivera, Thomas, D Pinkney, Willemijn van der Plas, Ahmad, Qureshi, Dejan, Radenkovic, Antonio Ramos- De la Medina, Keith, Roberts, April, C Roslani, Martin, Rutegå, Irè, ne, Santos, Raza, Sayyed, Andrew, Schache, Andreas, A Schnitzbauer, Seyi-Olajide, Justina O., Neil, Sharma, Richard, Shaw, Sebastian, Shu, Kjetil, Soreide, Antonino, Spinelli, Grant, D Stewart, Malin, Sund, Sudha, Sundar, Stephen, Tabiri, Georgios, Tsoulfas, Gabrielle, H van Ramshorst, Raghavan, Vidya, Dale, Vimalachandran, Oliver, J Warren, Duane, Wedderburn, Naomi, Wright, EuroSurg, European Society of Coloproctology (ESCP), Global Initiative for Children’, s Surgery (GICS), GlobalSurg, GlobalPaedSurg, ItSURG, PTSurg, SpainSurg, Italian Society of Colorectal Surgery (SICCR), Association of Surgeons in Training (ASiT), Irish Surgical Research Collaborative (ISRC), Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG), Collaborators (denotes Site Principal Investigators) Argentina: Allemand C, Italian Society of Surgical Oncology (SICO)., Boccalatte, L, Figari, M, Lamm, M, Larrañ, aga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L (Hospital Italiano De Buenos Aires), Alurralde, C, Caram, El, Eskinazi, D, Mendoza, Jp, Usandivaras M (Sanatorio, 9 De Julio Sa), Badra, R, Esteban, A, Garcí, a, Js, a, Pm, Gerchunoff, Ji, Lucchini, Sm, NIgra, Ma, Armenia: Hovhannisyan T, Vargas L (Sanatorio Allende)., Australia: Gould T, Stepanyan A (Nairi Medical Center)., Gourlay, R, Griffiths, B (Calvary Mater Newcastle), Gananadha S, McLaren M (Canberra Hospital), Cecire, J, Joshi, N, Salindera, S, Sutherland, A (Coffs Harbour Health Campus), Ahn, Jh, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H (Concord Repatriation General Hospital), Ballal, M, Gibson, D, Hayne, D, Moss, J, Richards, T, Viswambaram, P, Vo UG (Fiona Stanley Hospital), Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Lam, Yh, Ong, Bs, Szpytma, M, Watson, D (Flinders Medical Centre), Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Jeyarajan, E, Jordan, S, Lim, A, Nolan, Gj, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Townend, P, Von Papen, M, Wullschleger, M (Gold Coast University Hospital), Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N (John Hunter Hospital), Elliott M, Phung D (Lifehouse), Phan D, Townend D (Lismore Base Hospital), Bong C, Gundara J (Logan Hospital), Frankel, A (Princess Alexandra Hospital), Bowman S, Guerra GR (Queen Elizabeth Ii Jubilee Hospital), Bolt, J, Buddingh, K, Dudi-Venkata, Nn, Jog, S, Kroon, Hm, Sammour, T, Smith, R, Stranz, C (Royal Adelaide Hospital), Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Roberts, M, Sheahan, G, Swinson, B (Royal Brisbane And Women’, s Hospital), Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, Mw, Knowles, B, Mack, J, Read, M, Rowcroft, A, Ward, S, Austria: Lanner M (Kardinal Schwarzenberg Klinikum), Wright G (St Vincent’, s Hospital)., Kö, nigsrainer, I (Landeskrankenhaus Feldkirch), Bauer, M, Freyschlag, C, Kafka, M, Messner, F, 214, fner, D, Tsibulak, I (Medical University Of Innsbruck), Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, hlberger, L, Presl, J, Azerbaijan: Namazov İ, Wimmer A (Paracelsus Medical University Salzburg)., Barbados: Barker D, Samadov E (Leyla Medical Centerl)., Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O’, Shea, M, Padmore, G, Paquette, N, Phillips, E, John S, St., Belgium: Flamey N, Walkes K (Queen Elizabeth Hospital)., Pattyn, P (Az Delta), Oosterlinck, W, Van den Eynde, J, Brazil: Gatti A, Van den Eynde R (Uz Leuven)., Nardi, C, Oliva, R (Hospital Geral De Pirajussara), De Cicco, R (Instituto De Câ, ncer Dr Arnaldo Vieira De Carvalho), Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, F, Canada: Kidane B, Terra RM (Instituto Do Câ, ncer De Estado De Sã, o Paulo). Bulgaria: Sokolov M (University Hospital Alexandrovska)., Srinathan, S (Health Sciences Centre), Boutros, M, Caminsky, N, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S (Jewish General Hospital), Dumitra, S, Kouyoumdjian, A (Mcgill University Health Center), Johnston B, Russell C (Saint John Regional Hospital), Demyttenaere, S, Mary’, s Hospital), Garfinkle R (St., Abou-Khalil, J, Nessim, C, Colombia: Almeciga A, Stevenson J (The Ottawa Hospital). Chile: Heredia F (Clí, nica Universitaria De Concepció, n)., Fletcher, A, Merchan A (Centro De Investigaciones Oncoló, gicas Clí, nica San Diego, - Ciosad), Puentes LO (Hospital San José, Croatia: Bač, ić, G, Mendoza Quevedo J (Subred Sur Occidente De Kennedy (Hospital De Kennedy))., Karlović, D, Krš, ul, D, Zelić, M (University Hospital Center Rijeka), Luksic I, Mamic M (University Hospital Dubrava), Bakmaz, B, 262, oza, I, Dijan, E, Katusic, Z, Mihanovic, J, Cyprus: Frantzeskou K, Rakvin I (Zadar General Hospital)., Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Czechia: Martinek L, Yiallourou A (Nicosia General Hospital)., Skrovina, M, Szubota, I (Hospital &, amp, Oncological Centre Novy Jicin), 381, atecký, J (Slezská, Nemocnice V Opavě, P. o. ), Javurkova, V, Denmark: Avlund T, Klat J (University Hospital Ostrava)., Christensen, P, Harbjerg, Jl, Iversen, Lh, Kjaer, Dw, Kristensen, Hø, Mekhael, M (Aarhus University Hospital), Ebbehø, j, Al, Krarup, P, Schlesinger, N, Egypt: Abdelsamed A, Smith H (Bispebjerg Hospital)., Azzam, Ay, Salem, H, Seleim, A (Al Azhar University Hospitals), Abdelmajeed, A, Abdou, M, Abosamak, Ne, AL Sayed, M, Ashoush, F, Atta, R, Elazzazy, E, Elhoseiny, M, Elnemr, M, Elqasabi, Ms, Elsayed Hewalla ME, Elsherbini, I, Essam, E, Eweda, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, Qatora, Ms, Ragab, M, Sabry, A, Saifeldin, H, Saleh Mesbah Mohamed Elkaffas, M, Samih, A, Samir Abdelaal, A, Shehata, S, Shenit, K (Alexandria Main University Hospital), Attia, D, Kamal, N, Osman, N (Alexandria Medical Research Institute), Abbas, Am, Abd Elazeem HAS, Abdelkarem, Mm, Alaa, S, Ali, Ak, Ayman, A, Azizeldine, Mg, Elkhayat, H, elghazaly S, M., Monib, Fa, Nageh, Ma, Saad, Mm, Salah, M, Shahine, M, Yousof, Ea, Youssef, A (Assiut University Hospital), Eldaly, A (El-Menshawy Hospital), ElFiky, M, Nabil, A (Kasr Alainy Faculty Of Medicine, Cairo, University), Amira, G, Sallam, I, Sherief, M, Sherif, A (Misr Cancer Center), Abdelrahman, A, Aboulkassem, H, Ghaly, G, Hamdy, R, Morsi, A, Sherif, G (National Cancer Institute), Abdeldayem, H, Abdelkader Salama, I, Balabel, M, Fayed, Y, Sherif AE (National Liver Institute, Finland: Kauppila J, Menoufia University). Ethiopia: Bekele D (Maddawalabu University Goba Referral Hospital)., Sarjanoja, E (Lä, nsi-Pohja Central Hospital), Helminen, O, Huhta, H, France: Beyrne C, Kauppila JH (Oulu University Hospital)., Jouffret, L, Lugans, L, Marie-Macron, L (Centre Hospitalier Avignon), Chouillard E, De Simone B (Centre Hospitalier Intercommunal Poissy Saint Germain En Laye), Bettoni, J, Dakpé, S, Devauchelle, B, Lavagen, N, Testelin, S (Chu Amiens), Boucher, S, Breheret, R, Gueutier, A, Kahn, A, Kü, n-Darbois, J (Chu Angers), Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P (Chu Besanç, on), Chebaro, A, Drubay, V, El amrani, M, Eveno, C, Lecolle, K, Legault, G, Martin, L, Piessen, G, Pruvot, Fr, Truant, S, Zerbib, P (Chu Lille), Ballouhey, Q, Barrat, B, Laloze, J, Salle, H, Taibi, A, Usseglio, J (Chu Limoges), Bergeat D, Merdrignac A (Chu Rennes - General Surgery), Le Roy, B, Perotto, Lo, Scalabre, A (Chu Saint Etienne), Aimé, A, Ezanno, A, Malgras, B (Hia Begin), Bouche P, Tzedakis S (Hô, pital Cochin - Aphp), Cotte, E, Glehen, O, Lifante, J (Hopital Lyon Sud), D’, Urso, A, Felli, E, Mutter, D, Pessaux, P, Seeliger, B (Hus, Pole Hé, pato-Digestif, / Ihu- Strasbourg), Bardet, J, Berry, R, Boddaert, G, Bonnet, S, Brian, E, Denet, C, Fuks, D, Gossot, D, Grigoroiu, M, Laforest, A, Levy-Zauberman, Y, Louis-Sylvestre, C, Moumen, A, Pourcher, G, Seguin-givelet, A, Tribillon, E (Institut Mutualiste Montsouris), Duchalais, E, Espitalier, F, Ferron, C, Germany: Bork U, Malard O (Nantes University Hospital)., Distler, M, Fritzmann, J, Kirchberg, J, Praetorius, C, Riediger, C, Weitz, J, Welsch, T, Wimberger, P (Carl-Gustav-Carus University, Dresden), Tu, Beyer, K, Kamphues, C, Lauscher, J, Loch, Fn, Schineis, C (Charité, University Medicine, Campus Benjamin Franklin), Albertsmeier, M, Angele, M, Kappenberger, A, Niess, H, Schiergens, T, Werner, J (Department of General, Visceral and Transplantation Surgery, Ludwig- Maximilians-Universitat Munich), Becker R, Jonescheit J (Heilig-Geist Hospital Bensheim), Pergolini I, Reim D (Klinikum Rechts Der Isar Tum School Of Medicine), Boeker, C, Hakami, I, Mall, J (Krh Nordstadt-Siloah Hospitals), Liokatis P, Smolka W (LMU Klinikum Campus Innenstadt), Nowak K, Reinhard T (Romed Klinikum Rosenheim), Hö, lzle, F, Modabber, A, Winnand, P (University Hospital Aachen), Knitschke, M (University Hospital Giessen And Marburg), Kauffmann P, Wolfer S (University Hospital Goettingen / Universitä, tsmedizin Goettingen), Kleeff, J, Lorenz, K, Michalski, C, Ronellenfitsch, U, Schneider, R (University Hospital Halle (Saale)), Bertolani, E, nigsrainer, A, Lö, ffler, Mw, Quante, M, Steidle, C, 220, berrü, ck, L, Yurttas, C (University Hospital Tuebingen), Betz, Cs, Bewarder, J, Bö, ttcher, A, Burg, S, Busch, C, Gosau, M, Heuer, A, Izbicki, J, Klatte, To, Koenig, D, Moeckelmann, N, Nitschke, C, Priemel, M, Smeets, R, Speth, U, Thole, S, Uzunoglu, Fg, Vollkommer, T, Zeller, N (University Medical Center Hamburg- Eppendorf), Battista, Mj, Gillen, K, Hasenburg, A, Krajnak, S, Linz, V, Schwab, R (University Of Mainz, Greece: Angelou K, Department Of Gynaecology And Obstetrics)., Haidopoulos, D, Rodolakis, A (Alexandra General Hospital), Antonakis, P, Bramis, K, Chardalias, L, Contis, I, Dafnios, N, Dellaportas, D, Fragulidis, G, Gklavas, A, Konstadoulakis, M, Memos, N, Papaconstantinou, I, Polydorou, A, Theodosopoulos, T, Vezakis, A (Aretaieion Hospital), Antonopoulou, Mi, Manatakis, Dk, Tasis, N (Athens Naval And Veterans Hospital), Arkadopoulos, N, Danias, N, Economopoulou, P, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N, Selmani, J, Sidiropoulos, T, Tsaousis, V, Vassiliu, P (Attikon University General Hospital), Bouchagier, K, Klimopoulos, S, Paspaliari, D, Stylianidis, G (Evaggelismos General Hospital), Baxevanidou, K, Bouliaris, K, Chatzikomnitsa, P, Efthimiou, M, Giaglaras, A, Kalfountzos, C, Koukoulis, G, Ntziovara, Am, Petropoulos, K, Soulikia, K, Tsiamalou, I, Zervas, K, Zourntou, S (General Hospital Of Larissa “, Koutlimpaneio And Triantafylleio”, Baloyiannis, I, Diamantis, A, Gkrinia, E, Hajiioannou, J, Korais, C, Koukoura, O, Perivoliotis, K, Saratziotis, A, Skoulakis, C, Symeonidis, D, Tepetes, K, Tzovaras, G, Zacharoulis, D (General University Hospital Of Larissa), Alexoudi, V, Antoniades, K, Astreidis, I, Christidis, P, Deligiannidis, D, Grivas, T, Ioannidis, O, Kalaitsidou, I, Loutzidou, L, Mantevas, A, Michailidou, D, Paraskevopoulos, K, Politis, S, Stavroglou, A, Tatsis, D, Tilaveridis, I, Vahtsevanos, K, Venetis, G (George Papanikolaou General Hospital Of Thessaloniki), Karaitianos I, Tsirlis T (Henry Dunant Hospital Center), Charalabopoulos, A, Liakakos, T, Mpaili, E, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C (Laiko University Hospital), Anthoulakis, C, Christou, C, Papadopoulos, V, Tooulias, A, Tsolakidis, D, Tsoulfas, G, Zouzoulas, D (Papageorgiou General Hospital), Athanasakis, E, Chrysos, E, Tsiaousis, J, Xenaki, S, Hong Kong: Futaba K, Xynos E (University Hospital Of Heraklion Crete And Interclinic Hospital Of Crete)., Ho, Mf, Hon, Sf, Mak, Twc, Ng SSM (Prince Of Wales Hospital), Hungary: Banky B, Foo CC (Queen Mary Hospital)., Ireland: Aremu M, Susztá, k N (Szent Borbá, la Kó, rhá, z)., Canas-Martinez, A, Cullivan, O, Murphy, C, Owens, P, Pickett, L (Connolly Hospital Blanchardstown), Akmenkalne, L, Byrne, J, Corrigan, M, Cullinane, C, Daly, A, Fleming, C, Jordan, P, Killeen, S, Lynch, N, McCarthy, A, Mustafa, H, Brien, S, Leary, P, Syed, Was, Vernon, L (Cork University Hospital), Callanan, D, Huang, L, Ionescu, A, Sheahan, P (South Infirmary Victoria University Hospital), Balasubramanian, I, Boland, M, Conlon, K, Evoy, D, Fearon, N, Gallagher, T, Geraghty, J, Heneghan, H, Kennedy, N, Maguire, D, McCartan, D, McDermott, Ew, Prichard, Rs, Winter, D (St Vincent’, s University Hospital), Alazawi, D, Barry, C, Boyle, T, Butt, W, Connolly, Em, Donlon, N, Donohue, C, Fahey, Ba, Farrell, R, Fitzgerald, C, Kinsella, J, Larkin, Jo, Lennon, P, Maguire, Pj, Mccormick, P, Mehigan, Bj, Mohan, H, Nugent, T, Sullivan, H, Ravi, N, Reynolds, Jv, Rogers, A, Shokuhi, P, Smith, J, Smith, La, James’, s Hospital), Timon C (St., Bashir, Y, Bass, G, Connelly, T, Earley, H, Elliott, Ja, Gillis, A, Kavanagh, D, Neary, P, riordan, J, Reynolds, Is, Rice, D, Ridgway, P, Umair, M, Whelan, M (Tallaght Hospital), Carroll, P, Collins, C, Corless, K, Finnegan, L, Fowler, A, Hogan, A, Kerin, M, Lowery, A, McAnena, P, McKevitt, K, Nizami, K, Ryan, É, Samy, A (University Hospital Galway), Coffey, Jc, Cunningham, R, Devine, M, Nally, D, Peirce, C, Tormey, S (University Hospital Limerick), Hardy, N, Malley, S, Italy: Macina S (Asst Mantua), Ryan M (University Hospital Waterford/University College Cork)., Mariani, Nm, Opocher, E, Pisani Ceretti A (Asst Santi Paolo, E Carlo), Ferrari, F, Odicino, F, Sartori, E (Asst Spedali Civili, Ospedale Di Brescia), Cotsoglou C, Granieri S (Asst Vimercate), Bianco, F, Camillo’, Colledan, M, Tornese, S, Zambelli MF (Asst-Papa Giovanni Xxiii- Bergamo), Bissolotti, G, Fusetti, S, Lemma, F (Azienda Ospedaliera Di Padova), Marino, M, Mirabella, A, Vaccarella, G (Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo), Agostini, C, Alemanno, G, Bartolini, I, Bergamini, C, Bruscino, A, Checcucci, C, De Vincenti, R, Di Bella, A, Fambrini, M, Fortuna, L, Maltinti, G, Muiesan, P, Petraglia, F, Prosperi, P, Ringressi, Mn, Risaliti, M, Sorbi, F, Taddei, A, Tucci, R (Azienda Ospedaliera Universitaria Careggi), Bassi, C, Campagnaro, T, Casetti, L, De Pastena, M, Esposito, A, Fontana, M, Guglielmi, A, Landoni, L, Malleo, G, Marchegiani, G, Nobile, S, Paiella, S, Pedrazzani, C, Rattizzato, S, Ruzzenente, A, Salvia, R, Turri, G, Tuveri, M (Azienda Ospedaliera Universitaria Integrata Di Verona), Bellora, P, Aloisio, G, Ferrari, M, Francone, E, Gentilli, S, Nikaj, H (Azienda Ospedaliero Universitaria Maggiore Della Carità, Bianchini, M, Chiarugi, M, Coccolini, F, Di Franco, G, Furbetta, N, Gianardi, D, Guadagni, S, Morelli, L, Palmeri, M, Tartaglia, D (Azienda Ospedaliero Universitaria Pisana), Anania, G, Carcoforo, P, Chiozza, M, De Troia, A, Koleva Radica, M, Portinari, M, Sibilla, Mg, Urbani, A (Azienda Ospedaliero Universitaria Sant’, anna), Fabbri, N, Feo, Cv, Gennari, S, Parini, S, Righini E (Azienda Unità, Sanitaria Locale di Ferrara, - University of Ferrara), Ampollini, L, Bellanti, L, Bergonzani, M, Bertoli, G, Bocchialini, G, Angelo, G, Lanfranco, D, Musini, L, Poli, T, Santoro, Gp, Varazzani, A (Azienda Ospedaliero-Universitaria Di Parma), Aguzzoli, L, Borgonovo, G, Castro Ruiz, C, Coiro, S, Falco, G, Mandato, Vd, Mastrofilippo, V, Montella, Mt, Annessi, V, Zizzo M (Azienda Unità, Sanitaria Locale, - Irccs Di Reggio Emilia), Grossi, U, Novello, S, Romano, M, Rossi, S, Zanus, G (Ca’, Foncello Treviso-DISCOG-Universit Di Padova), Esposito, G, Frongia, F, Pisanu, A, Podda, M (Cagliari University Hospital), Belluco, C, Lauretta, A, Montori, G, Moras, L, Olivieri, M (Centro Di Riferimento Oncologico Di Aviano (Cro) Irccs), Bussu, F, Carta, Ag, Cossu, Ml, Cottu, P, Fancellu, A, Feo, Cf, Ginesu, Gc, Giuliani, G, Madonia, M, Perra, T, Piras, A, Porcu, A, Rizzo, D, Scanu, Am, Tedde, A, Tedde, M (Cliniche San Pietro, Sassari), A. o. u., Delrio, P, Rega D (Colorectal Surgical Oncology Unit, - Istituto Nazionale Tumori Fondazione, Pascale-I. r. c. c. s., ), Badalamenti, G, Campisi, G, Cordova, A, Franza, M, Maniaci, G, Rinaldi, G, Toia, F (Department Of Surgical, University Of Palermo), Oncological And Oral Sciences., Calabrò, M, Farnesi, F, Lunghi, Eg, Muratore, A, Pipitone Federico NS (Edoardo Agnelli), Bà, mbina, F, Andrea, G, Familiari, P, Picotti, V (Fabrizio Spaziani), De Palma, G, Luglio, G, Pagano, G, Tropeano FP (Federico Ii University Hospital), Baldari, L, Beltramini, Ga, Boni, L, Cassinotti, E, Gianni’, Pignataro, L, Torretta S (Fondazione Irccs Ca’, Granda, - Ospedale Maggiore Policlinico), Abatini, C, Baia, M, Biasoni, D, Bogani, G, Cadenelli, P, Capizzi, V, Cioffi, Spb, Citterio, D, Comini, Lv, Cosimelli, M, Fiore, M, Folli, S, Gennaro, M, Giannini, L, Gronchi, A, Guaglio, M, Macchi, A, Martinelli, F, Mazzaferro, V, Mosca, A, Pasquali, S, Piazza, C, Raspagliesi, F, Rolli, L, Salvioni, R, Sarpietro, G, Sarre, C, Sorrentino, L (Fondazione Irccs Istituto Nazionale Dei Tumori, Milano), Agnes, A, Alfieri, S, Belia, F, Biondi, A, Cozza, V, Amore, A, Ugo, D, De Simone, V, Fagotti, A, Gasparini, G, Gordini, L, Litta, F, Lombardi, Cp, Lorenzon, L, Marra, Aa, Marzi, F, Moro, A, Parello, A, Perrone, E, Persiani, R, Ratto, C, Rosa, F, Saponaro, G, Scambia, G, Scrima, O, Sganga, G, Tudisco, R (Fondazione Policlinico Universitario Agostino Gemelli), Belli, A, Granata, V, Izzo, F, Palaia, R, Patrone R (Hpb Surgical Oncology Unit, - Istituto Nazionale Tumori Fondazione, Pascale- I. r. c. c. s., ), Carrano, Fm, Carvello, Mm, De Virgilio, A, Di Candido, F, Ferreli, F, Gaino, F, Mercante, G, Rossi, V, Spinelli, A, Spriano, G (Humanitas Clinical And Research Center Irccs, Rozzano (Mi) &, Humanitas, University, Department Of Biomedical Sciences, Pieve Emanuele (Mi)), Donati, Dm, Frisoni, T, Palmerini, E (Irccs Istituto Ortopedico Rizzoli), Aprile, A, Barra, F, Batistotti, P, Ferrero, S, Fregatti, P, Scabini, S, Sparavigna, M (Irccs Ospedale Policlinico San Martino), Asti, E, Bernardi, D, Bonavina, L, Lovece, A (University of Milan, IRCCS Policlinico San Donato), Adamoli, L, Ansarin, M, Cenciarelli, S, Chu, F, De Berardinis, R, Fumagalli Romario, U, Mastrilli, F, Pietrobon, G, Tagliabue M (Istituto Europeo Di Oncologia, - Irccs -Milano), Badellino, E, Ferrero, A, Massobrio, R (Mauriziano Hospital Torino, Italy), De Manzoni Garberini, A (Ospedale Civile Spirito Santo), Federico, P, Maida, P, Marra, E, Marte, G, Petrillo, A, Tammaro, T, Tufo, A (Ospedale Del Mare), Berselli, M, Borroni, G, Cocozza, E, Conti, L, Desio, M, Livraghi, L, Quintodei, V, Rizzi, A, Zullo A (Ospedale Di Circolo, E Fondazione Macchi (Varese)), Baldi, C, Corbellini, C, Sampietro GM (Ospedale Di Rho, - Asst Rhodense), Cellerino P (Ospedale Fatebenefratelli, E Oftalmico), Baldini, E, Capelli, P, Isolani, Sm, Ribolla, M (Ospedale Guglielmo Da Saliceto Piacenza), Bondurri, A, Colombo, F, Ferrario, L, Guerci, C, Maffioli, A (Ospedale Luigi Sacco Milano), Armao, T, Ballabio, M, Bisagni, P, Gagliano, A, Longhi, M, Madonini, M, Pizzini, P (Ospedale Maggiore Di Lodi), Baietti, Am, Biasini, M, Maremonti, P, Neri, F, Prucher, Gm, Ricci, S, Ruggiero, F, Zarabini AG (Ospedale Maggiore/Bellaria Carlo Alberto Pizzardi Ausl Bologna), Barmasse, R, Mochet, S, Usai, A (Ospedale Regionale Umberto Parini), Leonardo - Asl Napoli 3 Sud, Incollingo P (Ospedale S., Castellammare Di Stabia), Mancini, S, Marino Cosentino, L, Sagnotta, A (Ospedale San Filippo Neri), Fruscio, R, Grassi, T, Nespoli, Lc, Tamini, N (Ospedale San Gerardo), Anastasi, A, Bartalucci, B, Bellacci, A, Canonico, G, Capezzuoli, L, Di Martino, C, Ipponi, P, Linari, C, Montelatici, M, Nelli, T, Spagni, G, Tirloni, L, Vitali, A (Ospedale San Giovanni Di Dio), Abate, E, Casati, M, Casiraghi, T, Laface, L, Schiavo M (Ospedale Vittorio Emanuele Iii, - Carate Brianza), Arminio, A, Cotoia, A, Lizzi, V, Vovola, F (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia), Vergari, R (Ospedali Riuniti Di Ancona), Ugo, S, Depalma, N, 8220, Vito Fazzi”, Spampinato MG (P. o., Bartolucci, P, Brachini, G, Bruzzaniti, P, Chiappini, A, Chiarella, V, Ciccarone, F, Cicerchia, Pm, Cirillo, B, De Toma, G, Di bartolomeo, A, Fiori, E, Fonsi, Gb, Franco, G, Frati, A, Giugliano, M, Iannone, I, La Torre, F, Lapolla, P, Leonardo, C, Marruzzo, G, Meneghini, S, Mingoli, A, Ribuffo, D, Salvati, M, Santoro, A, Sapienza, P, Scafa, Ak, Simonelli, L, Zambon M (Policlinico Umberto, I Sapienza University Of Rome), Capolupo, Gt, Carannante, F, Caricato, M, Mascianà, G, Mazzotta, E (Policlinico Universitario Campus Bio Medico Of Rome), Gattolin, A, Migliore, M, Rimonda, R, Sasia, D, Travaglio, E (Regina Montis Regalis Hospital, Mondovì, Cervellera, M, Gori, A, Sartarelli, L, orsola-Malpighi Hospital), Tonini V (S., Giacometti, M, Zonta, S (Ospedale San Biagio, Asl, VCO), Chessa, A, Fiorini, A, Norcini, C (San Giovanni Di Dio), Colletti, G, Confalonieri, M, Costanzi, A, Frattaruolo, C, Mari, G, Monteleone, M (San Leopoldo Mandic), Bandiera, A, Bocciolone, L, Bonavina, G, Candiani, M, De Nardi, P, Gagliardi, F, Medone, M, Mortini, P, Negri, G, Ottolina, J, Parise, P, Piloni, M, Sileri, P, Vignali, A (San Raffaele Scientific Institute, Milan), Belvedere, A, Bernante, P, Bertoglio, P, Boussedra, S, Brunocilla, E, Cipriani, R, Cisternino, G, De Crescenzo, E, De Iaco, P, Dondi, G, Frio, F, Jovine, E, Mineo Bianchi, F, Neri, J, Parlanti, D, Perrone, Am, Pezzuto, Ap, Pignatti, M, Pinto, V, Poggioli, G, Ravaioli, M, Rottoli, M, Schiavina, R, Serenari, M, Serra, M, Solli, P, Taffurelli, M, Tanzanu, M, Tesei, M, Violante, T, Zanotti, S (Sant’, orsola Hospital, Alma Mater Studiorum University Of Bologna, Borghi, F, Cianflocca, D, Di Maria Grimaldi, S, Donati, D, Gelarda, E, Geretto, P, Giraudo, G, Giuffrida, Mc, Marano, A, Palagi, S, Pellegrino, L, Peluso, C, Testa V (Santa Croce, E Carle Hospital, Cuneo), Agresta, F, Prando, D, Zese M (Santa Maria Degli Angeli Hospital Ulss5, - Adria), Aquila, F, Gambacciani, C, Lippa, L, Pieri, F, Santonocito OS (Spedali Riuniti Di Livorno), Armatura, G, Bertelli, G, Frena, A, Marinello, P, Notte, F, Patauner, S, Moritz Hospital), Scotton G (St., Fulginiti, Sf, Gallo, G, Sammarco, G, Vescio, G (University ‘, Magna Graecia’, Of Catanzaro), Balercia, P, Catarzi, L, Consorti G (University Hospital Umberto, I Ancona), Di Marzo, F (Valtiberina), Japan: Daiko H, Fontana T (Vittorio Emanuele)., Ishikawa, M, Ishiyama, K, Iwata, S, Kanematsu, K, Kanemitsu, Y, Kato, T, Kawai, A, Kobayashi, E, Kobayashi Kato, M, Moritani, K, Nakatani, F, Oguma, J, Tanase, Y, Jordan: Al Abdallah M, Uno M (National Cancer Center Hospital)., Ayasra, F, Ayasra, Y, Qasem, A (Al-Basheer Hospital), Abu Za’, nouneh FJ, Fahmawee, T, Hmedat, A, Ibrahim, A, Obeidat, K (King Abdullah University Hospital), Abdel Al, S, Abdel Jalil, R, Abou Chaar MK, Al-Masri, M, Al-Najjar, H, Alawneh, F, Alsaraireh, O, Elayyan, M, Ghanem, R, Libya: Alkadeeki G (Al-Jalaa Hospital), Lataifeh I (King Hussein Cancer Center)., Aldokali, N, Senossi, O, Subhi MT (Alkhadra Hospital), Burgan, D, Kamoka, E, Kilani, Ai, Salamah, A, Salem, M, Shuwayyah, A (National Cancer Institute, Sabratha, - Libya), Abdulwahed, E, Alshareea, E, Aribi, N, Aribi, S, Biala, M, Ghamgh, R, Morgom, M (Tripoli Central Hospital), Aldayri, Z, Ellojli, I, Lithuania: Bradulskis S, Kredan A (Tripoli University Hospital)., Dainius, E, Kubiliute, E, Kutkevič, ius, J, Parseliunas, A, Subocius, A, Madagascar: Rasoaherinomenjanahary F, Venskutonis D (Lithuanian University Of Health Sciences Kaunas Clinical Hospital)., Razafindrahita, Jb, Malaysia: Ong EC (Bintulu), Samison LH (Joseph Ravoahangy Andrianavalona Hospital)., Hamdan, Kh, Ibrahim, Mr, Tan, Ja, Thanapal MR (Hospital Kuala Lumpur), Amin Sahid, N, Hayati, F, Jayasilan, J, Sriram, Rk, Subramaniam, S (Queen Elizabeth Hospital &, Universiti Malaysia Sabah, Kota, Kinabalu, Sabah, Malaysia), Che Jusoh, A, Hussain, Ah, Mohamed Sidek AS, Mohd Yunus MF, Soh, Jy, Wong, Mpk, Zakaria, Ad, Zakaria, Z (School Of Medical Sciences &, Hospital, Universiti Sains Malaysia), Fadzli, A, Fathi, Nq, Koh, Ps, Liew, Yt, Roslani, Ac, Tang, Cy, Teoh, Ly, Wong, Wj, Mexico: Alvarez MR, Yahaya AS (University Malaya Medical Centre)., Arrangoiz, R, Cordera, F, De la Rosa Abaroa MA, Gó, mez-Pedraza, A, Hernandez, R, Maffuz-Aziz, A, Posada JA (Abc Medical Center), Becerra Garcí, a FC (Hospital San Á, ngel Inn Chapultepec), Alfaro-Goldaracena, A, Buerba, Ga, Castillejos- Molina RA, Chan, C, Dominguez-Rosado, I, Medina-Franco, H, Mercado, Má, Oropeza- Aguilar, M, Peñ, a Gó, mez Portugal, E, Posadas-Trujillo, Oe, Rodriguez-Covarrubias, F, Salgado-Nesme, N, Morocco: Arkha Y, Vilatoba M (Instituto Nacional De Ciencias Mé, dicas Y Nutrició, n “, Salvador Zubirá, n”, Bechri, H, El Ouahabi, A, Oudrhiri MY (Centre Hospitalier Universitaire Ibn Sina Rabat), Derkaoui hassani F, El abbadi N (Cheikh Zaid International University Hospital), Amrani, L, Belkhadir, Zh, Benkabbou, A, Chakib, O, El Ahmadi, B, El Bouazizi, Y, Essangri, H, Ghannam, A, Majbar, Am, Mohsine, R, Netherlands: Hompes R, Souadka A (Institut National D’, oncologie)., Meima-van Praag, E, Pronk, Ajm, Sharabiany, S (Amsterdam Umc, University Of Amsterdam), Grotenhuis, B, Hartveld, L, Reijers, S, Van Houdt, W (Antoni Van Leeuwenhoek Ziekenhuis), Baaij, J, Bolster-van Eenennaam, M, De Graaff, M, Sloothaak, D, Van Duijvendijk, P (Gelre Ziekenhuis), Posma-Bouman, L (Slingeland Ziekenhuis), Derksen, T, Franken, J, Oosterling, S (Spaarne Gasthuis), De Bree, R (University Medical Center Utrecht), Konsten, J, Nigeria: Fidelis L, Van Heinsbergen M (Viecuri Medisch Centrum)., Sholadoye, Tt, Tolani, M (Ahmadu Bello University Teaching Hospital), Olaogun, J (Ekiti State University Teaching Hospital), Egbuchulem, Ik, Lawal, Ta, Ogundoyin, O, Olulana DI (University College Hospital), Abdur-Rahman, L, Adeyeye, A, Aremu, I, Bello, J, Olasehinde, O, Oman: Massoud J, Popoola A (University Of Ilorin Teaching Hospital)., Massoud, R, Pakistan: Jamal A, Sorour TM (Khoula Hospital)., Kerawala AA (Cancer Foundation Hospital), Memon, As, Nafees Ahmed, R, Pfau Civil Hospital), Rai L (Dr Ruth K. m., Ayub, B, Hassan, N, Martins, Rs, Ramesh, P, Sayyed, R (Patel Hospital), Butt, U, Kashif, M, Khan, Wh, Qureshi, A, Umar, M, Waris Farooka, M, Wasim, T (Services Hospital Lahore), Ayubi, A, Rashid, I, Peru: Falcon GM, Waqar SH (The Pakistan Institute Of Medical Sciences)., Philippines: Jocson R, Robles R (Instituto Regional De Enfermedades Neoplá, sicas Del Sur)., Teh, C (National Kidney &, Poland: Major P (Jagiellonian University Medical College), Transplant Institute)., Bobiń, ski, M, Kotarski, J, Rasoul-Peliń, ska, K (Medical University Of Lublin, Portugal: Azevedo C, Chair And Department Of Gynaecological Oncology And Gynaecology)., Machado, D, Mendes, F (Centro Hospitalar Cova Da Beira), De Sousa, X (Centro Hospitalar De Setú, bal), Fernandes, U, Ferreira, C, Guidi, G, Leal, C, Març, al, A, Marques, R, Martins, D, Melo, A, Tenreiro, N, Vaz Pereira, R, Vieira B (Centro Hospitalar De Trá, s-Os-Montes, E Alto Douro, E. p. e., ), Almeida, Ji, Correia de Sá, T, Costa, Mjma, Fernandes, V, Ferraz, I, Gil, Cg, Lima da Silva, C, Lopes, L, Machado, N, Marialva, J, Nunes Coelho, M, Pedro, J, Pereira, C, Reis, R, Ribeiro, A, Santos, R, Saraiva, P, Silva, R, Tavares, F, Teixeira M (Centro Hospitalar Do Tamega, E Sousa), Almeida, Ac, Amaral, Mj, Andrade, R, Athayde Nemé, sio, R, Breda, D, Camacho, C, Canhoto, C, Colino, M, Correia, S, Costa, M, De Barros, J, De Oliveira Ló, pez AL, Duque, M, Garrido, S, Guerreiro, P, Guimarã, es, A, Lá, zaro, A, Lopes, C, Martins, R, Nogueira, O, Oliveira, A, Oliveira, Jm, Rodrigues, M, Ruivo, A, Santos, E, Silva, M, Simõ, es, J, Valente da Costa A (Centro Hospitalar, E Universitá, rio De Coimbra), Almeida, A, Cavaleiro, S, Devezas, V, Faria, Cs, Já, come, F, Magalhã, es Maia, M, Nogueiro, J, Pereira, A, Pereira-Neves, A, Pina-Vaz, T, Santos-Sousa, H, Silveira, H, Vaz, S, Vieira P (Centro Hospitalar, E Universitá, rio De Sã, o Joã, Gomes da Costa A, Lobo Antunes I (Centro Hospitalar Lisboa Norte), Pinto J, Tojal A (Centro Hospitalar Tondela-Viseu), Cardoso, N, Cardoso, P, Domingues, Jc, Henriques, P, Manso, Mi, Martins dos Santos, G, Morais, H, Pereira, R, Revez, T, Ribeiro, R, Ribeiro, Vi, Soares, A, Sousa, S, Teixeira J (Centro Hospitalar Universitá, rio Do Algarve, - Unidade De Faro), Amorim, E, Baptista, Vh, Cunha, Mf, Dias, B, Fazenda, A, Melo Neves JP, Policarpo, F, Sampaio da Nó, voa Gomes Miguel II, Veiga D (Centro Hospitalar Universitario Do Algarve, - Unidade De Portimã, Andrade, Ak, Bandovas, Jp, Borges, N, Branquinho, A, Chumbinho, B, Correia, J, Fidalgo, H, Figueiredo de Barros, I, Frade, S, Gomes, J, Maciel, J, Pina, S, Rodrigues, A, Silva, N, Silveira Nunes, I, Sousa, R (Centro Hospitalar Universitá, rio Lisboa Central), Ascensã, o, J, Azevedo, P, Costeira, B, Cunha, C, Garrido, R, Gomes, H, Lourenç, o, I, Mendinhos, G, Miranda, P, Nobre Pinto, A, Peralta Ferreira, M, Ribeiro, J, Rio Rodrigues, L, Sousa Fernandes, M (Hospital Beatriz Angelo), Azevedo J (Hospital Da Horta, E. p. e. ), Galvã, o, D, Soares, Ac, Vieira, A, Vieira, B (Hospital De Santo Espirito Da Ilha Terceira), Patrí, cio, B, Santos, Pmdd, Vieira Paiva Lopes AC (Hospital De Torres Vedras, - Centro Hospitalar Do Oeste), Cunha, R, Faustino, A, Freitas, A, Martins, Ab, Mendes, Jr, Parreira, R, Rosa, J, Teves, M (Hospital Do Divino Espí, rito Santo), Abreu da Silva, A, Claro, M, Costa Santos, D, Deus, Ac, Grilo JV (Hospital Do Litoral Alentejano), Borges, F, Corte Real, J, Henriques, S, Lima, Mj, Matos Costa, P (Hospital Garcia De Orta), Brito da Silva, F, Caiado, A, Fonseca, F (Instituto Portuguê, s De Oncologia De Lisboa Francisco Gentil), 194, ngelo, M, Baiao, Jm, Martins Jordã, Vieira Caroç, o, T (Ipo Coimbra), Messias, J, Millan, A, Salgado, I, Santos, P (Ipo Lisboa), Baí, a, C, Canotilho, R, Correia, Am, Ferreira Pinto AP, Peyroteo, M, Puerto Rico: Escobar P, Videira JF (Ipo Porto)., Ré, union: Kassir R, Maldonado Santiago M (Instituto Gineco Oncologico)., Romania: Bezede C, Sauvat F (Chu Reunion)., Chitul, A, Ciofic, E, Cristian, D, Grama, F (Coltea Clinical Hospital), Pirtea L, Secosan C (Emergency Clinical City Hospital), Bonci, E, Gata, V, Ion Chiricuta Institute Of Oncology), Titu S (Prof. Dr., Ginghina, O, Iordache, N, Russia: Garmanova T, Iosifescu RV (Saint John Emergency Hospital)., Kazachenko, E, Markaryan, D, Rodimov, S, Tsarkov, P, Tulina, I (Clinic Of Coloproctology And Minimally Invasive Surgery, Sechenov Medical State University), Litvina, Y, Provozina, A (Immanuel Kant Baltic Federal University, Regional Clinical Hospital), Agapov, M, Galliamov, E, Kakotkin, V, Kubyshkin, V, 1050, 1072, 1084, 1083, 1086, 1074, А, (Moscow Research And Educational Center, Saudi Arabia: Alshahrani M, Lomonosov Moscow State University)., Alsharif, F, Eskander, M (Aseer Central Hospital), Al Raddadi, R, Majrashi, S, Mashat, A (East Jeddah General Hospital), Akeel, N, Alharthi, M, Aljiffry, M, Basendowah, M, Farsi, A, Ghunaim, M, Khoja, A, Maghrabi, A, Malibary, N, Nassif, M, Nawawi, A, Saleem, A, Samkari, A, Trabulsi, N (King Abdulaziz University Hospital), Al Awwad, S, Alghamdi, M, Alnumani, T, Nasser, M, Said bayazeed, A (King Fahad General Hospital), Alhefdhi, A, Almalik, O, Alomair, A, Alotaibi, N, Alresaini, F, Alsalamah, R, Alsobhi, S, Mahasin, Z, Othman, E, Velagapudi, S (King Faisal Specialist Hospital), Al Habes, H, Alamri, A, Alkarak, S, Alqannas, M, Alyami, M, Alzamanan, M, Corté, s Guiral, D, Elawad, A (King Khalid Hospital), AlAamer, O, Alriyees, L, Alselaim, N (King Saud Bin Abdulaziz University For Health Sciences, King Abdullah International Medical Research Center, Ministry Of National Guard, Health, Affairs, General Surgery Department., ), Abdulkareem, A, Ajlan, A, Akkour, K, Al-Habib, A, Al-Khayal, K, Alatar, A, Alburakan, A, Alhalal, H, Alhassan, B, Alhassan, N, Alobeed, O, Alsaif, A, Alsaif, F, Alshammari, S, Alshaygy, I, Barry, M, Bin Nasser, A, Bin Traiki, T, Bokhari, A, Elwatidy, S, Helmi, H, Madkhali, A, Nouh, T, Rabah, Pd, Serbia: Paunovic I, Zubaidi A (King Saud University)., Slijepcevic, N (Centre For Endocrine Surgery, Clinical Centre Of Serbia), Aleksić, L, Antic, A, Barisic, G, Ceranic, M, Galun, D, Grubač, Ž, Jelenkovic, J, Kecmanović, Kmezić, Knezevic, D, Krivokapic, Z, Latinč, Markovic, V, Matić, Miladinov, M, Pavlov, M, Pejovic, I, Radenkovic, D, Tadic, B, Vasljević, J, Velickovic, D, Zivanovic, M (Clinic For Digestive Surgery, Perovic M, Srbinovic L (Clinic For Gynecology And Obstetrics Narodni Front), Andrijasevic, S, Bozanovic, T, Cerovic Popovic, R, Dokic, M, Janjic, T, Jeremic, K, Kadija, S, Ladjevic Likic, I, Mirkovic, L, Pantovic, S, Pilic, I, Radojevic, M, Stefanovic, A, Vidakovic, S, Vilendecic, Z (Clinic For Gynecology And Obstetrics, Clinical Center Of Serbia), Antic, S, Dunđ, erović, Jelovac, D, Jezdic, Z, Konstantinovic, V, Kotlar, B, Kuzmanovic, C, Lazić, Petrovic, M, Popovic, F, Pucar, A, Romic, M, Sumrak, S, Vujanac, V (Clinic For Maxillofacial Surgery, School Of Dental Medicine, University Of Belgrade), Bascarevic, V, Bogdanović, I, Grujič, Ilic, R, Milić, ević, Milisavljević, F, Miljković, Paunovic, A, 352, 263, epanović, V, Stanimirovic, A, Todorovic, M (Clinic For Neurosurgery, Jotic, A, Milovanovic, J, Trivic, A (Clinic For Otorhinolaryngology And Maxillofacial Surgery, Bumbasirevic, U, Dzamic, Z, Kajmaković, B, Prijović, N, Zivkovic, M (Clinic Of Urology, Buta, M, Cvetkovic, A, Djurisic, I, Gacic, S, Goran, M, Inic, Z, Jeftic, N, Jevric, M, Jokic, V, Markovic, I, Milanović, Nikolic, S, Pejnovic, L, Savković, Spurnic, I, Stevic, D, Stojiljkovic, D, Vucic, N, Zegarac, M (Institute For Oncology And Radiology Of Serbia), Karamarkovic, A, Kenic, M, Kovacevic, B, Krdzic, I, Singapore: Chan CW, Milutinović, V (Zvezdara University Medical Center)., Slovakia: Gá, lis B, Lieske B (National University Hospital)., South Africa: Almgla N, Š, imko K (University Hospital Bratislava)., Bernon, M, Boutall, A, Cairncross, L, Herman, A, Hilton, T, Jonas, E, Kloppers, C, Malherbe, F, Mugla, W, Nel, D, Rayamajhi, S, Van Wyngaard, T, Spain: Castañ, o-Leon AM, Vogel J (Groote Schuur Hospital)., Delgado Fernandez, J, Eiriz Fernandez, C, Espino Segura-Illa, M, Esteban Sinovas, O, Garcia Perez, D, Gomez, P, Jimenez-Roldan, L, Lagares, A, Moreno- Gomez, L, Paredes, I, Pé, rez Nú, 241, ez, A, Sá, nchez Aniceto, G, Santas, M (12 De Octubre University Hospital), Ferná, ndez Rodrí, guez, P, Paniagua Garcí, a Señ, orans, M, Sanchez- Santos, R, Vigorita, V (Á, lvaro Cunqueiro Hospital), Acrich, E, Baena Sanfeliu, E, Barrios, O, Golda, T, Santanach, C, Serrano-Navidad, M, Sorribas Grifell, M, Vives RV (Bellvitge University Hospital), Escolà, D, Jimé, nez A (Comarcal Alt Penedé, Cayetano Paniagua L, Gó, mez Ferná, ndez L (Consorci Sanitari De Terrassa), Artigues, E, Bernal-Sprekelsen, Jc, Catalá, Bauset JC (Consorcio Hospital General Universitario), Collera, P, Diaz Del Gobbo, R, Farre Font, R, Flores Clotet, R, mez Dí, az CJ, Guà, rdia, N, Guariglia, Ca, Osorio, A, Sanchez Jimenez, R, Sanchon, L, Soto Montesinos C (Fundació, Althaia, - Xarxa Assistencial Università, ria De Manresa), Albi Martin B, Garcí, a Villayzá, n JE (Fundació, n Jimenez Diaz University Hospital), Alonso-Lamberti, L, Assaf, M, Baeza Pintado, N, Carabias, A, a-Quijada, J, Huertas Fernandez MA, Jimenez Miramó, n, J, Jimenez, V, Jover, Jm, Landeo Agü, ero SA, Leon, R, Martí, n Salamanca MB, rez Simó, n, V, Ponce, S, Rodriguez, Jl, Salazar, A, Valle Rubio, A (Getafe University Hospital), Aguado, H (Hellí, n Hospital), Aldecoa Ansorregui, I, Bravo Infante, R, De Lacy FB, Di Somma, A, Dí, az-Feijoo, B, Enseñ, at Nora, J, Fabregas, N, Ferré, s, A, Gil Ibañ, ez, B, Gonzalez Sanchez JJ, Gracia, I, Hoyos Castro JA, Lacy, Am, Langdon, C, Momblá, n, D, Morales, X, Oleaga, L, Otero, A, Pedrosa, L, Poblete Carrizo, J, Reyes Figueroa LA, Roldan Ramos, P, Rumia-Arboix, J, Tercero-Uribe, Ai, Topczewski, Te, Torales, J, Torne, A, Torné, R, Turrado-Rodriguez, V, Valero, R, Valverde, S (Hospital Clinic Barcelona), Anula, R, Cano-Valderrama, O, Del Campo Martí, n, M, ez-Valladares, L, Domí, nguez, I, Dziakova, J, a Alonso, M, a Romero, E, mez Latorre, L, Muguerza, Jm, Pizarro, Mj, Saez Carlin, P, nchez del Pueblo, C, nchez-Pernaute, A, Sanz Ortega, G, Sanz-Lopez, R, Torres, A (Hospital Clí, nico De Madrid), Garcé, s-Albir, M, Lopez, F, n-Aré, valo, J, Moro-Valdezate, D, Pla-Marti, V (Hospital Clí, nico Universitario De Valencia), Beltrá, n de Heredia, J, De André, s Asenjo, B, mez Sanz, T, Jezieniecki, C, Nuñ, ez Del Barrio, H, Ortiz de Soló, rzano Aurusa FJ, Romero de Diego, A, Ruiz Soriano, M, Trujillo Dí, az, J, Vazquez fernandez, A (Hospital Clí, nico Universitario De Valladolid), Lora-Cumplido P, Sosa MV (Hospital De Cabueñ, es), Gonzalez-Gonzalez E, Minaya Bravo AM (Hospital Del Henares), Alonso de la Fuente, N, Cazador Labat, M, Cecchini, L, Espinosa, Ca, Jimenez Toscano, M, Ló, pez Campillo, A, Mancebo, G, Martorell, P, Munarriz, M (Hospital Del Mar), Grau-Talens EJ, Martin-Perez B (Hospital Don Benito-Villanueva), Benavides Buleje JA, Carrasco Prats, M, ndez, Pv, ndez-Ló, pez, A, a Escudero, D, a Porcel VJ, Garcia Soria, V, Gimé, nez Francé, s, C, Gonzá, lez Valverde FM, Gurrea, E, pez-Morales, P, Marco Garrido, A, nez Alonso JA, Medina, E, Muñ, oz Camarena JM, Parra Bañ, os PA, a Ros, E, Ramirez Faraco, M, Ruiz-Marí, Sanchez Rodriguez, C, Valero Soriano, M (Hospital General Reina Sofí, Estaire Gó, mez, M, ndez Camuñ, as, Á, Garcia Santos EP, Jimenez Higuera, E, nez-Pinedo, C, oz-Atienza, V, Padilla-Valverde, D, Picó, n Rodrí, guez, R, Redondo Calvo FJ, nchez-Garcí, a, S, Sanchez-Pelaez, D (Hospital General Universitario De Ciudad Real), Colombari, Rc, Del valle, E, ndez, M, Lozano Lominchar, P, n, L, Rey Valcarcel, C, Steiner, Ma, Tudela, M, Zorrilla Ortú, zar, J (Hospital General Universitario Gregorio Marañ, 243, Alcaide Matas, F, a Pé, rez JM, Troncoso Pereira, P (Hospital Mateu Orfila), Mora-Guzmá, n, I (Hospital Santa Bá, rbara), Abellá, Achalandabaso Boira, M, Jorba, R, Memba Ikuga, R, Olona, C, Sales Mallafré, R (Hospital Universitari De Tarragona Joan Xxiii), Cavallé, Busquets, P, Gavalda Pellice MGP, Salinas Peñ, a, J (Hospital Universitari Sant Joan), Aragon Achig EJ, Barbier, L, Caja Vivancos, P, Gainza, A, a Gutierrez JJ, Mallabiabarrena Ormaechea, G, Marí, n, H, Martin Playa, P, Melchor Corcó, stegui, I, Prieto Calvo, M, Rodriguez Fraga, A, Villalabeitia Ateca, I (Hospital Universitario Cruces), De Andres Olabarria, U, Durá, n Ballesteros, M, ndez Pablos FJ, Ibá, ez-Aguirre, Fj, Sanz Larrainzar, A, Ugarte-Sierra, B (Hospital Universitario De Galdakao), De la Hoz Rodrí, guez, Á, Di Martino, M, a Septiem, J, Martin-Perez, E, oz de Nova JL (Hospital Universitario De La Princesa), Calvo Espino P, Guillamot Ruano P (Hospital Universitario De Mó, stoles), Colao Garcí, a, L, az Pé, rez, D, Esteban Agustí, E, Galindo Jara, P, Gutierrez Samaniego, M, Hernandez Bartolome MA, Serrano Gonzá, lez, J (Hospital Universitario De Torrejó, n De Ardoz), Alonso Poza, A, Dié, guez, B, a-Conde, M, Herná, ndez-Garcí, a, M, Losada, M (Hospital Universitario Del Sureste), Chiesa-Estomba, Cm, lez Garcí, a JÁ, Larruscain, E, Sistiaga-Suá, rez JA (Hospital Universitario Donostia), Alvarez, E, Chavarrias, N, Frí, as, L, a Pineda, V, Gegú, ndez Simó, n, A, Gortá, zar, S, Gracia, M, Guevara, J, ndez Gutierrez, A, Loayza, A, a Dolores DT, C, Melendez, M, Moreno-Palacios, E, Perez, Y, Prieto Nieto MI, Ramos- Martí, n, P, Rubio-Perez, I, Saavedra, J, Sanchez-Mendez, Ji, Siegrist Ridruejo, J, Urbieta, A, Zapardiel, I (Hospital Universitario La Paz), Cantalejo diaz, M, De Miguel Ardevines MDC, Duque-Mallé, Gascon Ferrer, I, lez-Nicolá, s Tré, bol MT, Gracia-Roche, C, Herrero Lopez, M, Jariod Ferrer UM, Lanzon, A, Martinez German, A, Matute, M, Redondo, C, nchez Fuentes, N, nchez-Rubio, M, Santero-Ramirez, Ms, Saudí, Simó, n Sanz MV, Uson-Bouthelier, T (Hospital Universitario Miguel Servet), Blazquez Martin, A, Diez Alonso, M, a Rico, E, Garcia-Loarte Gomez, E, Garcia-Moreno Nisa, F, Gutierrez Calvo, A, Hernandez, P, Lasa, I, Mendoza-Moreno, F, Morales Palacios, N, Ovejero Merino, E, Vera Mansilla, C (Hospital Universitario Principe De Asturias), Acebes Garcí, a, F, Bailó, Bueno Cañ, ones AD, Choolani Bhojwani, E, Marcos-Santos, P, Miguel, T, Pacheco Sá, nchez, D, rez-Saborido, B, Sanchez Gonzalez, J, Tejero-Pintor FJ (Hospital Universitario Rí, o Hortega), Alconchel, F, Conesa, A, Gil Martí, nez, J, Gutié, rrez Ferná, ndez AI, Lopez Abad, A, Nicolá, s-Ló, pez, T, Ramirez Romero, P, Roca Calvo MJ, Rodrigues, K, Ruiz Manzanera JJ, Soriano AI (Hospital Universitario Virgen De La Arrixaca), Cano, A, Capitan-Morales, L, Cintas Catena, J, Gomez-Rosado, J, Oliva Mompean, F, rez Sá, nchez MA, Rí, o Lafuente FD, Torres Arcos, C, Valdes-Hernandez, J (Hospital Universitario Virgen Macarena), Cholewa, H, Domingo, S, Frasson, M, Lago, V, Marina Martin, T, nez Chicote, C, Sancho-Muriel J (Hospital Universitario, Y Polité, cnico La Fe), Landaluce-olavarria A, Lecumberri D (Hospital Urduliz), Abad Gurumeta, A, Abad-Motos, A, nez-Hurtado, E, Ripollé, s-Melchor, J, Ruiz Escobar, A (Infanta Leonor University Hospital), Cuadrado- Garcí, a, A, Garcia-Sancho Tellez, L, Heras Aznar, J, Maté, P, Ortega Vá, zquez, I, Picardo, Al, Rojo Ló, pez JA, Sanchez Cabezudo Noguera, F, Serralta de Colsa, D (Infanta Sofí, a University Hospital), Anchuelo Latorre, J, Cagigas Fernandez, C, Caiñ, a Ruiz, R, Gomez Ruiz, M, Hernanz, F, Jimeno Fraile, J, nez-Pé, rez, P, Poch, C, Santarrufina Martinez, S, Valbuena Jabares, V (Marqué, s De Valdecilla University Hospital), Moliner-Sá, nchez, C, Pingarron-Martin, L, Rey-Biel, J, Ruiz Martin, I (Rey Juan Carlos University Hospital), Blas Laina JL, Cros, B, Escartin, J, Garcia Egea, J, Nogué, Talal El-Abur, I, Yá, nez, C (Royo Villanova), Cagigal Ortega EP, Cervera, I, az Peñ, a, P, Elena, Gdcr, Enjuto, D, ndez Bernabé, s Garcí, a, R, Gonzalez, J, ndez, I, Herrera-Merino, N, Marqueta De Salas, M, Martinez Pascual, P, Perez Gonzalez, M, Ramos Bonilla, A, Rodrí, guez Gó, mez, L (Severo Ochoa University Hospital), Bescó, Blanco-Colino, R, Brana, I, Caimari, B, De Pablo Garcí, a-Cuenca, A, Duran-Valles, F, Espin-Basany, E, Giralt Ló, pez de Sagredo, J, Pamias, J, Pellino, G, Prat, N, Pujol Pina, R, Sri Lanka: Arulanantham A, Saez barba M (Vall D’, hebron University Hospital)., Bandara, Gbk, Jayarajah, U, Ravindrakumar, S, Rodrigo VS (District General Hospital Chilaw), Srishankar S (Teaching Hospital Anuradhapura). Sudan: Ali karar AA (Al-Rajhi). Sweden: Elbe P, Lindqvist EK (Karolinska University Hospital), Taflin, H (Sahlgrenska University Hospital), 196, lgå, Heinius, G, Nordberg, M, Pieniowski, E (South General Hospital), Gkekas, I, fgren, N, Rutegå, rd, M, Switzerland: Arigoni M, Sund M (Umea University Hospital)., Bernasconi, M, Christoforidis, D, Di Giuseppe, M, La Regina, D, Mongelli, F (Ente Ospedaliero Cantonale), Chevallay, M, Dwidar, O, Gialamas, E, Sauvain, M (Hopital De Pourtales), Klenke, F, Kollà, r, A, Kurze, C (Inselspital, Bern University Hospital, University Of Bern), Adamina, M, Bä, chler, T, Crugnale, As, Giardini, M, Guglielmetti, L, Peros, G, Turkey: Aghayeva A, Solimene F (Kantonsspital Winterthur)., Hamzaoglu, I, Sahin, I (Acibadem Altunizade Hospital), Akaydin, E, Aliyeva, Z, Aytac, E, Baca, B, Dü, lgeroğ, lu, O, Ozben, V, Ozmen, Bb, Uras, C (Acibadem Atakent Hospital), Arikan, Ae, Bilgin, Ia, Bozkı, rlı, Ceyhan, Go, Kara, H, Karahasanoğ, lu, T, Uras, C (Acibadem Maslak Hospital), Celik, H (Adana Baskent University), Meydanli MM (Ankara City Hospital), Akilli, H, Ayhan, A, Kuscu, E (Baskent University), Onan MA (Gazi University Medical Faculty Hospital), Akgor, U, Dincer, Ha, Erol, T, Gultekin, M, Orhan, N, Ozgul, N, Salman, Mc, Soyak, B (Hacettepe University Hospital), Alhamed, A, Ergü, n, S, OZcelı, k, Mf, Sanli, An, Uludağ, Velidedeoglu, M, Zengin AK (Istanbul Universty, - Cerrahpaş, a Medical Faculty), Bozkurt, Ma, Kara, Y, Kocataş, A (Kanuni Sultan Suleyman Training And Research Hospital), Cimenoglu, B, Demirhan, R, Lutfi Kirdar Training And Research Hospital), Saracoglu K (Kartal Dr., Azamat, İ, f, Balik, E, Buğ, ra, D, Giray, B, Kulle, Cb, Taskiran, C, Vatansever, D (Koç, University Medical School), Gö, zal, K, Gü, ler, Sa, ken, H, Tatar, Oc, Utkan, Nz, Yı, ldı, rı, m, A, Yü, ksel, E (Kocaeli University Teaching Hospital), Akin, E, Altintoprak, F, Bayhan, Z, Cakmak, G, 199, apoğ, lu, R, elebi, F, Demir, H, Dikicier, E, Firat, N, nü, llü, Kamburoğ, lu, Mb, Kocer, B, 231, 252, k, If, Mantoglu, B (Sakarya University Faculty Of Medicine), olak, E, Kucuk, Go, Uyanik MS (Samsun Training And Research Hospital), 304, lhan Varank Training And Research Hospital), Gö, ksoy B (Sehit Prof. dr., Bozkurt, E, Citgez, B, Mihmanli, M, Tanal, M, Yetkin, G (Sisli Hamidiye Etfal Training And Research Hospital), Akalin, M, Arican, C, Avci, Ek, Aydin, C, Demirli Atı, cı, Emiroglu, M, Kaya, T, Kebabç, 305, Kilinc, G, Kirmizi, Y, 287, cü, H, Salimoğ, lu, S, Sert, İ, Tugmen, C, Tuncer, K, Uslu, G, Yeş, ilyurt, D (University Of Health Sciences Tepecik Training And Research Hospital), Karaman, E, Kolusarı, A (Van Yuzuncu Yil University, Medical, Faculty), Uganda: Benson O, Yildiz A (Yildirim Beyazit University Yenimahalle Training And Research Hospital)., United Kingdom: Agilinko J, Lule H (Kampala International University Teaching Hospital)., Ahmeidat, A, Barabasz, M, Bekheit, M, Cheung, Lk, Colloc, T, Cymes, W, Elhusseini, M, Gradinariu, G, Hannah, A, Kamera, Bs, Mignot, G, Shaikh, S, Sharma, P (Aberdeen Royal Infirmary), Abu-Nayla, I, Agrawal, A, Al-Mohammad, A, Ali, S, Ashcroft, J, Azizi, A, Baker, O, Balakrishnan, A, Byrne, M, Colquhoun, A, Cotter, A, Coughlin, P, Davies, Rj, Durrani, A, Elshaer, M, Fordington, S, Forouhi, P, Georgiades, F, Grimes, H, Habeeb, A, Hudson, V, Hutchinson, P, Irune, E, Jah, A, Khan, Dz, Kolias, A, Kyriacou, H, Lamb, B, Liau, S, Luke, L, Mahmoud, R, Mannion, R, Masterson, L, Mitrofan, Cg, Mohan, M, Morris, A, Murphy, S, Neill, R, Price, S, Pushpa-rajah, J, Raby-Smith, W, Ramzi, J, Rooney, S, Santarius, T, Singh, A, Stewart, Gd, Tan, Xs, Townson, A, Tweedle, E, Walker, C, Waseem, S, Yordanov, S (Addenbrooke’, Jones, T, Kattakayam, A, Loh, C, Lunevicius, R, Pringle, S, Schache, A, Shaw, R, Sheel, A (Aintree University Hospital), Rossborough, C (Altnagelvin Area Hospital), Angelou, D, Choynowski, M, McAree, B, McCanny, A, Neely, D (Antrim Area Hospital- Northern Health And Social Care Trust), Tutoveanu, G (Barnsley Hospital Nhs Foundation Trust), Ahad, S, De La Cruz Monroy MFI, Mosley, F, Oktseloglou, V (Bradford Royal Infirmary), Alanbuki, A, Patel, M, Shabana, A (Brighton And Sussex Nhs Trust, Princess Royal Hospital), Perera, E, Raveendran, D, Ravi- Shankar, K, Thiruchelvam, J (Broomfield Hospital), Arrowsmith L, Campbell W (Causeway Hospital), Grove, T, Kontovounisios, C, Warren, O (Chelsea And Westminster Hospital), Rolland, P (Cheltenham General Hospital), Aggarwal, A, Brown, S, Jelley, C, Neal, N (Churchill Hospital), Clifford, R, Eardley, N, Krishnan, E, Manu, N, Martin, E, Roy Mahapatra, S, Serevina, Ol, Smith, C, Vimalachandran, D (Countess Of Chester Hospital), Bordenave, M, Houston, R, Putnam, G, Robson, A, Tustin, H (Cumberland Infirmary), Emslie, K, Labib, Pl, Marchbank, A, Miller, D, Minto, G, Natale, J, Nwinee, H, Panahi, P, Rogers, L (Derriford Hospital), Abubakar, A, Akhter Rahman MM, Kyk, Ko, Brien, H, Sasapu, K, Woodun, H (Diana Princess Of Wales Hospital Grimsby), Inglis R, Ng HJ (Dumfries And Galloway Royal Infirmary), De Gea Rico, A, Ghazali, N, Lambert, J, Markose, G, Math, S, Sarantitis, I, Shrestha, D, Sultana, A, Taggarsi, M, Timbrell, S, Vaz, Op, Vitone, L (East Lancashire Hospitals Nhs Trust), Day, A, Dent, H, Fahim, M, Waheed, S (East Surrey Hospital), Hunt A, Laskar N (East Sussex Healthcare (Conquest Hospital And Eastbourne District General Hospital)), Gupta, A, Steinke, J, Thrumurthy, S (Epsom &, St Helier University Hospitals Nhs Trust), Massie, E, McGivern, K, Rutherford, D, Wilson, M (Forth Valley Royal Hospital), Hardie J, Kazzaz S (Frimley Health Nhs Ft - Frimley Park), Handa, S, Kaushal, M, Kler, A, Patel, P, Redfern, J, Tezas, S (Furness General Hospital), Aawsaj, Y, Amonkar, S, Blackwell, L, Blake, D, Carter, J, Emerson, H, Fisher, A, Katory, M, Korompelis, P, McCormick, W, Mustafa, A, Pearce, L, Ratnavelu, N, Reehal, R (Gateshead Health Nhs Foundation Trust), Kretzmer, L, Lalou, L, Manku, B, Parwaiz, I, Stafford, J (George Eliot Hospital), Abdelkarim, M, Asqalan, A, Gala, T, Ibrahim, S, Maw, A, Mithany, R, Morgan, R, Sundaram Venkatesan, G (Glan Clwyd Hospital), Ang, K, Caruana, Ej, Chowdhry, Mf, Mohammad, A, Nakas, A, Rathinam, S (Glenfield Hospital), Boal, M, Brown, O, Dwerryhouse, S, Higgs, S, Vallance, A (Gloucestershire Royal Hospital), Boyd, E, Irvine, V, Kirk, A (Golden Jubilee National Hospital), Bakolas, G, Boulton, A, Chandock, A, Khan, T, Kumar, M (Good Hope Hospital), Agoston, P, Billè, Challacombe, B, Fraser, S, Harrison-Phipps, K, King, J, Mehra, G, Mills, L, Najdy, M, Nath, R, Okiror, L, Pilling, J, Rizzo, V, Routledge, T, Sayasneh, A, Stroman, L, Wali, A (Guy’, Fehervari, M, Fotopoulou, C, Habib, N, Hamrang-Yousefi, S, Jawad, Z, Jiao, L, Pai, M, Ploski, J, Rajagopal, P, Saso, S, Sodergren, M, Spalding, D (Hammersmith Hospital), Laws, S (Hampshire Hospitals Nhs Trust), Hardie C, McNaught C (Harrogate District Hospital), Alam, R, Budacan, A, Cahill, J, Kalkat, M, Karandikar, S, Kenyon, L, Naumann, D, Patel, A (Heartlands Hospital), Ayorinde, J, Chase, T, Cuming, T, Ghanbari, A, Humphreys, L, Tayeh, S (Homerton University Hospital), Aboelkassem Ibrahim, A, Bichoo, R, Cao, H, Chai, Akw, Choudhury, J, Evans, C, Fitzjohn, H, Ikram, H, Langstroth, M, Loubani, M, McMillan, A, Nazir, S, Qadri, Ssa, Robinson, A, Ross, E, Sehgal, T, Wilkins, A (Hull University Teaching Hospitals Nhs Trust), Dixon, J, Dunning, J, Freystaetter, K, Jha, M, Lester, S, Madhavan, A, Thulasiraman, Sv, Viswanath, Y (James Cook University Hospital), Curl-Roper, T, Delimpalta, C, Liao, Ccl, Velchuru, V, Westwood, E (James Paget Univeristy Nhs Foundation Trust Hospital), Belcher, E, Bond-Smith, G, Chidambaram, S, Di Chiara, F, Fasanmade, K, Fraser, L, Fu, H, Ganau, M, Gore, S, Graystone, J, Jeyaretna, D, Khatkar, H, Lami, M, Maher, M, Mastoridis, S, Mihai, R, Piper, R, Prabhu, S, Risk, Obf, Selbong, U, Shah, K, Smillie, R, Soleymani majd, H, Sravanam, S, Stavroulias, D, Tebala, Gd, Vatish, M, Verberne, C, Wallwork, K, Winter, S (John Radcliffe Hospital), Bhatti, Mi, Boyd-Carson, H, Elsey, E, Gemmill, E, Herrod, P, Jibreel, M, Lenzi, E, Saafan, T, Sapre, D, Sian, T, Watson, N (King’, s Mill Hospital), Athanasiou, A, Bourke, G, Bradshaw, L, Brunelli, A, Burke, J, Coe, P, Costigan, F, Elkadi, H, Ho, M, Johnstone, J, Kanatas, A, Kantola, V, Kaufmann, A, Laios, A, Lam, S, MacInnes, E, Munot, S, Nahm, C, Otify, M, Pompili, C, Smith, I, Theophilou, G, Toogood, G, Wade, R, Ward, D, West, C (Leeds Teaching Hospitals Trust), Annamalai, S, Ashmore, C, Boddy, A, Hossain, T, Kourdouli, A (Leicester Royal Infirmary), Gvaramadze, A, Jibril, A, Prusty, L, Thekkinkattil, D (Lincoln County Hospital), Harky A, Shackcloth M (Liverpool Heart And Chest Hospital), Askari, A, Cirocchi, N, Kudchadkar, S, Patel, K, Sagar, J, Shaw, S, Talwar, R (Luton And Dunstable University Hospital), Abdalla, M, Edmondson, R, Ismail, O, Jones, D, Newton, K, Stylianides, N (Manchester Royal Infirmary), Aderombi, A, Andaleeb, U, Bajomo, O, Beatson, K, Garrett, W, Mehmood, M, V (Medway Hospital), Ng, Al-Habsi, R, Divya, Gs, Keeler, B (Milton Keynes University Hospital), Al- Sarireh, B, Egan, R, Harries, R, Henry, A, Kittur, M, Li, Z, Parkins, K, Soliman, F, Spencer, N, Thompson, D (Morriston Hospital Swansea), Burgess, C, Gemmell, C, Grieco, C, Hollyman, M, Hunt, L, Morrison, J, Ojha, S, Ryan, N (Musgrove Park Hospital), Abbadessa, F, Barnard, S, Dawe, N, Hammond, J, Mahmoud Ali, F, McPherson, I, Mellor, C, Moir, J, Pandanaboyana, S, Powell, J, Rai, B, Roy, C, Sachdeva, A, Saleh, C, Tingle, S, Williams T (Newcastle Upon Tyne Hospitals Nhs Foundation Trust., ), Manickavasagam, J, McDonald, C, McGrath, N, McSorley, N, Ragupathy, K, Ramsay, L, Solth, A (Ninewells Hospital), Kakisi, O, Seebah, K, Shaikh, I, Sreedharan, L, Youssef, M (Norfolk And Norwich University Hospital), Shah, J (North Manchester General Hospital), Ameerally, P (Northampton General Hospital), McLarty, N, Mills, S, Shenfine, A (Northumbria Nhs Hospital Trust), Sahnan, K (Northwick Park Hospital), Abu, J, Addae-Boateng, E, Bratt, D, Brock, L, Burnside, N, Cadwell-Sneath, S, Gajjar, K, Gan, C, Grundy, C, Hallam, K, Hassell, K, Hawari, M, Joshi, A, Khout, H, Konstantinidi, K, Lee, Rxn, Nunns, D, Schiemer, R, Walton, T, Weaver, H, Whisker, L, Williamson, K (Nottingham City Hospital), McVeigh, J, Myatt, R, Williams MA (Nuffield Orthopaedic Centre), Kaur, R, Leung, E, Sundar, S (Pan- Birmingham Gynaecological Cancer Centre), Michel, M, Patil, S, Ravindran, S, Sarveswaran, J, Scott, L (Pinderfields Hospital), Edmond M, King E (Poole Hospital), Almond, M, Bhangu, A, Breik, O, Cato, Ld, Desai, A, Ford, S, Griffiths, E, Idle, M, Kamal, M, Kisiel, A, Kulkarni, R, Mak, Jkc, Martin, T, Nankivell, P, Parente, A, Parmar, S, Pathanki, Am, Phelan, L, Praveen, P, Saeed, S, Sharma, N, Singh, J, Tirotta, F, Vijayan, D (Queen Elizabeth Hospital Birmingham), Geddes, A, McCaul, J, McMahon, J (Queen Elizabeth University Hospital), Khan, Ah, Khan, F, Mansuri, A, Mukherjee, S, Sarigul, M, Singh, S, Tan, Kl, Woodham, A (Queen’, s Hospital Romford), Adiamah, A, Brewer, H, Chowdhury, A, Evans, J, Humes, D, Jackman, J, Koh, A, Lewis-Lloyd, C, Oyende, O, Reilly, J, Worku, D (Queens Medical Centre), Cool, P, Cribb, G, Shepherd, K (Robert Jones And Agnes Hunt Orthopaedic Hospital), Bisset C, Moug S (Royal Alexandra Hospital), Elson, N, Faulkner, G, Saleh, P, Underwood, C (Royal Bolton Hospital), Brixton, G, Findlay, L, Klatte, T, Majkowska, A, Manson, J, Potter, R (Royal Bournemouth Hospital), Bhalla, A, Chia, Z, Daliya, P, Goyal, A, Grimley, E, Hamad, A, Kumar, A, Malcolm, Fl, Theophilidou, E (Royal Derby Hospital), Bowden, J, Campain, N, Daniels, I, Fowler, G, John, J, Massey, L, McDermott, F, McGrath, J, McLennan, A, Ng, M, Pascoe, J, Rajaretnam, N (Royal Devon And Exeter Hospital), Bulathsinhala, S, Davidson, B, Fusai, G, Hidalgo Salinas, C, Machairas, N, Pissanou, T, Pollok, Jm, Raptis, Da, Soggiu, F, Tzerbinis, H, Xyda SE (Royal Free Hospital), Beamish, A, Davies, E, Foulkes, R, Magowan, D, Nassa, H, Ooi, R, Price, C, Smith, L, Solari, F, Tang, A, Williams, G (Royal Gwent Hospital), Al-Tamimi, Y, Bacon, A, Beasley, N, Chew, D, Crank, M, Ilenkovan, N, Macdonald, M, Narice, B, Rominiyi, O, Thompson, A, Varley, I (Royal Hallamshire Hospital), Drake, T, Harrison, E, Linder, G, Mayes, J, McGregor, R, Skipworth, R, Zamvar, V (Royal Infirmary Of Edinburgh), Hawkin, P, Raymond, T, Ryska, O (Royal Lancaster Infirmary), Baron, R, Dunne, D, Gahunia, S, Halloran, C, Howes, N, McKinney, R, McNicol, F, Russ, J, Szatmary, P, Tan, Jr, Thomas, A, Whelan, P (Royal Liverpool University Hospital), Anzak, A, Banerjee, A, Fuwa, O, Hughes, F, Jayasinghe, Jd, Knowles, C, Kocher, H, Leal Silva, I, Ledesma, Fs, Minicozzi, A, Navaratne, L, Rahman, R, Ramamoorthy, R, Sohrabi, C, Thaha, M, Thakur, B, Venn, M, Yip, V (Royal London Hospital), Baumber R, Parry J (Royal National Orthopaedic Hospital), Evans, S, Jeys, L, Morris, G, Parry, M, Stevenson, J (Royal Orthopaedic Hospital), Ahmadi, N, Aresu, G, Barrett-Brown, Zm, Coonar, As, Durio Yates, H, Gearon, D, Hogan, J, King, M, Peryt, A, Pradeep, Is, Smith, C (Royal Papworth Hospital), Adishesh, M, Atherton, R, Baxter, K, Brocklehurst, M, Chaudhury, M, Krishnamohan, N, McAleer, J, Owens, G, Parkin, E, Patkar, P, Phang, I (Royal Preston Hospital), Aladeojebi, A, Ali, M, Barmayehvar, B, Gaunt, A, Gowda, M, Halliday, E, Kitchen, M, Mansour, F, Thomas, M, Zakai, D (Royal Stoke University Hospital), Abbassi-Ghadi, N, Assalaarachchi, H, Currie, A, Flavin, M, Frampton, A, Hague, M, Hammer, C, Hopper, J, Horsnell, J, Humphries, S, Kamocka, A, Madhuri, Tk, Preston, S, Singh, P, Stebbing, J, Tailor, A, Walker, D (Royal Surrey County Hospital), Aljanadi, F, Jones, M, Mhandu, P, Donnell, C, Turkington, R (Royal Victoria Hospital, Belfast), Al-Ishaq, Z, Bhasin, S, Bodla, As, Burahee, A, Crichton, A, Fossett, R, Pigadas, N, Rahman, E, Snee, D, Vidya, R, Yassin, N (Royal Wolverhampton Nhs Trust), Fountain, D, Hasan, Mt, Karabatsou, K, Laurente, R, Pathmanaban, O (Salford Royal Hospital), Al-mukhtar, A, Edwards, J, Giblin, A, Kelty, C, Lee, M, Lye, G, Newman, T, Sharkey, A, Steele, C, Sureshkumar Shah, N, Whitehall, E (Sheffield Teaching Hospital Nhs Foundation Trust), Athwal, R, Baker, A, Jones, L, Konstantinou, C, Ramcharan, S, Vatish, J, Wilkin, R (South Warwickshire Nhs Foundation Trust), Ethunandan, M, Sekhon, Gk, Shields, H, Singh, R, Wensley, F (Southampton General Hospital), Lawday S, Lyons A (Southmead Hospital), Abbott, T, Anwar, S, Ghufoor, K, Sohrabi, C (St Bartholomew’, s Hospital (Non-Cardiac Unit)), Chung, E, Hagger, R, Hainsworth, A, Karim, A, Owen, H, Ramwell, A, Williams, K (St George’, Baker, C, Davies, A, Gossage, J, Kelly, M, Knight, W (St Thomas’, Hospital), Hall, J (Stepping Hill Hospital), Harris, G, James, G, Kang, C, Lin, Dj, Rajgor, Ad, Royle, T, Scurrah, R, Steel, B, Watson LJ (Sunderland Royal Hospital), Choi, D, Hutchison, R, Jain, A, Luoma, V, Marcus, H, May, R, Menon, A, Pramodana, B, Webber, L (The National Hospital For Neurology And Neurosurgery), Aneke, Ia, Asaad, P, Brown, B, Collis, J, Duff, S, Khan, A, Moura, F, Wadham, B, Warburton, H (The University Hospital Of South Manchester), Elmoslemany, T, Jenkinson, M, Millward, C, Zakaria, R (The Walton Centre Nhs Foundation Trust), Mccluney, S, Parmar, C, Shah, S (The Whittington Hospital), Allison, J, Babar, Ms, Collard, B, Goodrum, S, Lau, K, Patel, A, Scott, R, Thomas, E, Whitmore, H (Torbay And South Devon Nhs Trust), Balasubramaniam, D, Jayasankar, B, Kapoor, S, Ramachandran, A (Tunbridge Wells Hospital), Elhamshary, A, Imam, Smb, Kapriniotis, K, Kasivisvanathan, V, Lindsay, J, Rakhshani-Moghadam, S (University College London Hospital At Westmoreland Street), Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, McEwen, R, Schilling, C, Sinha, D (University College London Hospital), Pereca J, Singh J (University Hospital Ayr), Chopra, S, Egbeare, D, Thomas, R (University Hospital Llandough), Combellack, T, Jones, Sef, Kornaszewska, M, Mohammed, M, Sharma, A, Tahhan, G, Valtzoglou, V, Williams, J (University Hospital Of Wales), Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, T, Newton, C, Olivier, J, Rozwadowski, S, Teh, E, West, D (University Hospitals Bristol NHS Foundation Trust), Al-omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar, A, McEvoy, K, Naredla, P, Ng, V, Robertson, S, Sait, M, Sarma, Dr, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G (University Hospitals Coventry And Warwickshire Nhs Trusts), Akhtar, Ma, Brunt, A, McIntyre, J, Milne, K, Rashid, Mm, Sgrò, Stewart, Ke, Turnbull, A (Victoria Hospital Kirkcaldy), Aguilar Gonzalez M, Talukder S (West Suffolk Hospital), Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D (Western General Hospital), Bath, M, Patki, P, Tanabalan, C (Whipps Cross University Hospital), Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R (Wirral University Teaching Hospital), Flindall, I, Hanson, A, Mahendran, V (Worcestershire Royal Hospital), Green, S, Lim, M, MacDonald, L, Miu, V, Onos, L, Sheridan, K, Young, R (York Teaching Hospitals Nhs Trust), Alam, F, Griffiths, O, Houlden, C, Jones, R, Kolli, Vs, Lala, Ak, Leeson, S, Peevor, R, United States of America: Chen L, Seymour Z (Ysbyty Gwynedd)., Henderson, E, Loehrer, A (Dartmouth-Hitchcock Medical Center), Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, McElhinney, K, Olson, K, Osterberg, Ec, Riley, C, Srikanth, P, Thornhill, M (Dell Seton Medical Center At The University Of Texas), Blazer, D, DiLalla, G, Hwang, Es, Lee, W, Lidsky, M, Plichta, J, Rosenberger, L, Scheri, R, Turnage, K, Visgauss, J, Zani, S (Duke University Medical Center), Farma, J (Fox Chase Cancer Center), Clark J, Kwon D (Henry Ford Hospital), Etchill, E, Gabre-Kidan, A, Jenny, He, Kent, A, Ladd, M, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P (Johns Hopkins Hospital), Dehal, A (Kaiser Permanente Panorama City Medical Center), Klaristenfeld, D (Kaiser Permanente San Diego Medical Center), Huynh, K (Kaiser Permanente West Los Angeles), Brown L, Ganly I (Memorial Sloan Kettering Cancer Center), Mullinax, J (Moffitt Cancer Center), Gusani, N, Hazelton, J, Maines, J, Oh, Js, Ssentongo, A, Ssentongo, P (Pennsylvania State University), Azam, M, Choudhry, A, Marx, W (Suny Upstate University Hospital), Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y (University Of Alabama Birmingham), Abel, Mk, Boeck, Ma, Chern, H, Corvera, C, El- sayed, I, Glencer, A, Ha, P, Hamilton, Bcs, Heaton, C, Hirose, K, Jablons, Dm, Kirkwood, K, Kornblith, Lz, Kratz, Jr, Lee, R, Miller, Pn, Nakakura, E, Nunez-Garcia, B, Ozgediz, D, Sarin, A, Sheu, B, Varma, M, Wai, K, Xu MJ (University Of California, San Francisco (UCSF)), Beswick, D, Goddard, J, Manor, J, Song, J (University Of Colorado Hospital/Memorial Hospital/Medical Center Of The Rockies (All Within Uchealth System)), Fullmer, T, Gaskill, C, Gross, N, Kiong, K, Roland, Cl, Zafar SN (University Of Texas Md Anderson Cancer Center), Abdallah, M, Abouassi, A, Almasri, M, Kulkarni, G, Marwan, H, Mehdi, M (University Of Texas Medical Branch), Aoun, S, Ban, Vs, Batjer, Hh, Caruso, J (University Of Texas Southwestern), Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, P, Zafar SN (University Of Wisconsin), Hawkins, A, Uruguay: Laufer J, Maiga A (Vanderbilt University Medical Center)., Scasso, S (Hospital Pereira Rossell, Montevideo, )., Glasbey, J. C., Nepogodiev, D., Simoes, J. F. F., Omar, O., Li, E., Venn, M. L., Chaar, M. K. A., Capizzi, V., Chaudhry, D., Desai, A., Edwards, J. G., Evans, J. P., Fiore, M., Videria, J. F., Ford, S. J., Ganly, I., Griffiths, E. A., Gujjuri, R. R., Kolias, A. G., Kaafarani, H. M. A., Minaya-Bravo, A., Mckay, S. C., Mohan, H. M., Roberts, K. J., Miguel-Mendez, C. S., Pockney, P. G., Shaw, R., Smart, N. J., Stewart, G. D., Sundar, S., Vidya, R., Bhangu, A. A., Allemand, C., Boccalatte, L., Figari, M., Lamm, M., Larranaga, J., Marchitelli, C., Noll, F., Odetto, D., Perrotta, M., Saadi, J., Zamora, L., Alurralde, C., Caram, E. L., Eskinazi, D., Mendoza, J. P., Usandivaras, M., Badra, R., Esteban, A., Garcia, J. S., Garcia, P. M., Gerchunoff, J. I., Lucchini, S. M., Nigra, M. A., Vargas, L., Hovhannisyan, T., Stepanyan, A., Gould, T., Gourlay, R., Griffiths, B., Gananadha, S., Mclaren, M., Cecire, J., Joshi, N., Salindera, S., Sutherland, A., Ahn, J. H., Charlton, G., Chen, S., Gauri, N., Hayhurst, R., Jang, S., Jia, F., Mulligan, C., Yang, W., Ye, G., Zhang, H., Ballal, M., Gibson, D., Hayne, D., Moss, J., Richards, T., Viswambaram, P., Vo, U. G., Bennetts, J., Bright, T., Brooke-Smith, M., Fong, R., Gricks, B., Lam, Y. H., Ong, B. S., Szpytma, M., Watson, D., Bagraith, K., Caird, S., Chan, E., Dawson, C., Ho, D., Jeyarajan, E., Jordan, S., Lim, A., Nolan, G. J., Oar, A., Parker, D., Puhalla, H., Quennell, A., Rutherford, L., Townend, P., Von Papen, M., Wullschleger, M., Blatt, A., Cope, D., Egoroff, N., Fenton, M., Gani, J., Lott, N., Shugg, N., Elliott, M., Phung, D., Phan, D., Townend, D., Bong, C., Gundara, J., Frankel, A., Bowman, S., Guerra, G. R., Bolt, J., Buddingh, K., Dudi-Venkata, N. N., Jog, S., Kroon, H. M., Sammour, T., Smith, R., Stranz, C., Batstone, M., Lah, K., Mcgahan, W., Mitchell, D., Morton, A., Pearce, A., Roberts, M., Sheahan, G., Swinson, B., Alam, N., Banting, S., Chong, L., Choong, P., Clatworthy, S., Foley, D., Fox, A., Hii, M. W., Knowles, B., Mack, J., Read, M., Rowcroft, A., Ward, S., Wright, G., Lanner, M., Konigsrainer, I., Bauer, M., Freyschlag, C., Kafka, M., Messner, F., Ofner, D., Tsibulak, I., Emmanuel, K., Grechenig, M., Gruber, R., Harald, M., Ohlberger, L., Presl, J., Wimmer, A., Namazov, I., Samadov, E., Barker, D., Boyce, R., Corbin, S., Doyle, A., Eastmond, A., Gill, R., Haynes, A., Millar, S., O'Shea, M., Padmore, G., Paquette, N., Phillips, E., S, t. John S., Walkes, K., Flamey, N., Pattyn, P., Oosterlinck, W., Van Den Eynde, J., Van Den Eynde, R., Gatti, A., Nardi, C., Oliva, R., De Cicco, R., Cecconello, I., Gregorio, P., Pontual Lima, L., Ribeiro, U., Takeda, F., Terra, R. M., Sokolov, M., Kidane, B., Srinathan, S., Boutros, M., Caminsky, N., Ghitulescu, G., Jamjoum, G., Moon, J., Pelletier, J., Vanounou, T., Wong, S., Dumitra, S., Kouyoumdjian, A., Johnston, B., Russell, C., Demyttenaere, S., Garfinkle, R., Abou-Khalil, J., Nessim, C., Stevenson, J., Heredia, F., Almeciga, A., Fletcher, A., Merchan, A., Puentes, L. O., Mendoza Quevedo, J., Bacic, G., Karlovic, D., Krsul, D., Zelic, M., Luksic, I., Mamic, M., Bakmaz, B., Coza, I., Dijan, E., Katusic, Z., Mihanovic, J., Rakvin, I., Frantzeskou, K., Gouvas, N., Kokkinos, G., Papatheodorou, P., Pozotou, I., Stavrinidou, O., Yiallourou, A., Martinek, L., Skrovina, M., Szubota, I., Zatecky, J., Javurkova, V., Klat, J., Avlund, T., Christensen, P., Harbjerg, J. L., Iversen, L. H., Kjaer, D. W., Kristensen, H. O., Mekhael, M., Ebbehoj, A. L., Krarup, P., Schlesinger, N., Smith, H., Abdelsamed, A., Azzam, A. Y., Salem, H., Seleim, A., Abdelmajeed, A., Abdou, M., Abosamak, N. E., AL-Sayed, M., Ashoush, F., Atta, R., Elazzazy, E., Elhoseiny, M., Elnemr, M., Elqasabi, M. S., Elsayed Hewalla, M. E., Elsherbini, I., Essam, E., Eweda, M., Ghallab, I., Hassan, E., Metwalli, M., Mourad, M., Qatora, M. S., Ragab, M., Sabry, A., Saifeldin, H., Saleh Mesbah Mohamed Elkaffas, M., Samih, A., Samir Abdelaal, A., Shehata, S., Shenit, K., Attia, D., Kamal, N., Osman, N., Abbas, A. M., Abd Elazeem, H. A. S., Abdelkarem, M. M., Alaa, S., Ali, A. K., Ayman, A., Azizeldine, M. G., Elkhayat, H., Melghazaly, S., Monib, F. A., Nageh, M. A., Saad, M. M., Salah, M., Shahine, M., Yousof, E. A., Youssef, A., Eldaly, A., Elfiky, M., Nabil, A., Amira, G., Sallam, I., Sherief, M., Abdelrahman, A., Aboulkassem, H., Ghaly, G., Hamdy, R., Morsi, A., Sherif, G., Abdeldayem, H., Abdelkader Salama, I., Balabel, M., Fayed, Y., Sherif, A. E., Bekele, D., Sarjanoja, E., Helminen, O., Huhta, H., Kauppila, J. H., Beyrne, C., Jouffret, L., Lugans, L., Marie-Macron, L., Chouillard, E., De Simone, B., Bettoni, J., Dakpe, S., Devauchelle, B., Lavagen, N., Testelin, S., Boucher, S., Breheret, R., Gueutier, A., Kahn, A., Kun-Darbois, J., Barrabe, A., Lakkis, Z., Louvrier, A., Manfredelli, S., Mathieu, P., Chebaro, A., Drubay, V., El amrani, M., Eveno, C., Lecolle, K., Legault, G., Martin, L., Piessen, G., Pruvot, F. R., Truant, S., Zerbib, P., Ballouhey, Q., Barrat, B., Laloze, J., Salle, H., Taibi, A., Usseglio, J., Bergeat, D., Merdrignac, A., Le Roy, B., Perotto, L. O., Scalabre, A., Aime, A., Ezanno, A., Malgras, B., Bouche, P., Tzedakis, S., Cotte, E., Glehen, O., Kepenekian, V., Lifante, J., Passot, G., D'Urso, A., Felli, E., Mutter, D., Pessaux, P., Seeliger, B., Bardet, J., Berry, R., Boddaert, G., Bonnet, S., Brian, E., Denet, C., Fuks, D., Gossot, D., Grigoroiu, M., Laforest, A., Levy-Zauberman, Y., Louis-Sylvestre, C., Moumen, A., Pourcher, G., Seguin-Givelet, A., Tribillon, E., Duchalais, E., Espitalier, F., Ferron, C., Malard, O., Bork, U., Distler, M., Fritzmann, J., Kirchberg, J., Praetorius, C., Riediger, C., Weitz, J., Welsch, T., Wimberger, P., Beyer, K., Kamphues, C., Lauscher, J., Loch, F. N., Schineis, C., Albertsmeier, M., Angele, M., Kappenberger, A., Niess, H., Schiergens, T., Werner, J., Becker, R., Jonescheit, J., Pergolini, I., Reim, D., Boeker, C., Hakami, I., Mall, J., Liokatis, P., Smolka, W., Nowak, K., Reinhard, T., Holzle, F., Modabber, A., Winnand, P., Knitschke, M., Kauffmann, P., Wolfer, S., Kleeff, J., Lorenz, K., Michalski, C., Ronellenfitsch, U., Schneider, R., Bertolani, E., Konigsrainer, A., Loffler, M. W., Quante, M., Steidle, C., Uberruck, L., Yurttas, C., Betz, C. S., Bewarder, J., Bottcher, A., Burg, S., Busch, C., Gosau, M., Heuer, A., Izbicki, J., Klatte, T. O., Koenig, D., Moeckelmann, N., Nitschke, C., Priemel, M., Smeets, R., Speth, U., Thole, S., Uzunoglu, F. G., Vollkommer, T., Zeller, N., Battista, M. J., Gillen, K., Hasenburg, A., Krajnak, S., Linz, V., Schwab, R., Angelou, K., Haidopoulos, D., Rodolakis, A., Antonakis, P., Bramis, K., Chardalias, L., Contis, I., Dafnios, N., Dellaportas, D., Fragulidis, G., Gklavas, A., Konstadoulakis, M., Memos, N., Papaconstantinou, I., Polydorou, A., Theodosopoulos, T., Vezakis, A., Antonopoulou, M. I., Manatakis, D. K., Tasis, N., Arkadopoulos, N., Danias, N., Economopoulou, P., Kokoropoulos, P., Larentzakis, A., Michalopoulos, N., Selmani, J., Sidiropoulos, T., Tsaousis, V., Vassiliu, P., Bouchagier, K., Klimopoulos, S., Paspaliari, D., Stylianidis, G., Baxevanidou, K., Bouliaris, K., Chatzikomnitsa, P., Efthimiou, M., Giaglaras, A., Kalfountzos, C., Koukoulis, G., Ntziovara, A. M., Petropoulos, K., Soulikia, K., Tsiamalou, I., Zervas, K., Zourntou, S., Baloyiannis, I., Diamantis, A., Gkrinia, E., Hajiioannou, J., Korais, C., Koukoura, O., Perivoliotis, K., Saratziotis, A., Skoulakis, C., Symeonidis, D., Tepetes, K., Tzovaras, G., Zacharoulis, D., Alexoudi, V., Antoniades, K., Astreidis, I., Christidis, P., Deligiannidis, D., Grivas, T., Ioannidis, O., Kalaitsidou, I., Loutzidou, L., Mantevas, A., Michailidou, D., Paraskevopoulos, K., Politis, S., Stavroglou, A., Tatsis, D., Tilaveridis, I., Vahtsevanos, K., Venetis, G., Karaitianos, I., Tsirlis, T., Charalabopoulos, A., Liakakos, T., Mpaili, E., Schizas, D., Spartalis, E., Syllaios, A., Zografos, C., Anthoulakis, C., Christou, C., Papadopoulos, V., Tooulias, A., Tsolakidis, D., Tsoulfas, G., Zouzoulas, D., Athanasakis, E., Chrysos, E., Tsiaoussis, J., Xenaki, S., Xynos, E., Futaba, K., Ho, M. F., Hon, S. F., Mak, T. W. C., Ng, S. S. M., Foo, C. C., Banky, B., Susztak, N., Aremu, M., Canas-Martinez, A., Cullivan, O., Murphy, C., Owens, P., Pickett, L., Akmenkalne, L., Byrne, J., Corrigan, M., Cullinane, C., Daly, A., Fleming, C., Jordan, P., Killeen, S., Lynch, N., Mccarthy, A., Mustafa, H., O'Brien, S., O'Leary, P., Syed, W. A. S., Vernon, L., Callanan, D., Huang, L., Ionescu, A., Sheahan, P., Balasubramanian, I., Boland, M., Conlon, K., Evoy, D., Fearon, N., Gallagher, T., Geraghty, J., Heneghan, H., Kennedy, N., Maguire, D., Mccartan, D., Mcdermott, E. W., Prichard, R. S., Winter, D., Alazawi, D., Barry, C., Boyle, T., Butt, W., Connolly, E. M., Donlon, N., Donohue, C., Fahey, B. A., Farrell, R., Fitzgerald, C., Kinsella, J., Larkin, J. O., Lennon, P., Maguire, P. J., Mccormick, P., Mehigan, B. J., Nugent, T., O'Sullivan, H., Ravi, N., Reynolds, J. V., Rogers, A., Shokuhi, P., Smith, J., Smith, L. A., Timon, C., Bashir, Y., Bass, G., Connelly, T., Creavin, B., Earley, H., Elliott, J. A., Gillis, A., Kavanagh, D., Neary, P., O'Riordan, J., Reynolds, I. S., Rice, D., Ridgway, P., Umair, M., Whelan, M., Carroll, P., Collins, C., Corless, K., Finnegan, L., Fowler, A., Hogan, A., Kerin, M., Lowery, A., Mcanena, P., Mckevitt, K., Nizami, K., Ryan, E., Samy, A., Coffey, J. C., Cunningham, R., Devine, M., Nally, D., Peirce, C., Tormey, S., Hardy, N., O'Malley, S., Ryan, M., Macina, S., Mariani, N. M., Opocher, E., Pisani Ceretti, A., Ferrari, F., Odicino, F., Sartori, E., Cotsoglou, C., Granieri, S., Bianco, F., Camillo, A., Colledan, M., Tornese, S., Zambelli, M. F., Bissolotti, G., Fusetti, S., Lemma, F., Marino, M. V., Mirabella, A., Vaccarella, G., Agostini, C., Alemanno, G., Bartolini, I., Bergamini, C., Bruscino, A., Checcucci, C., De Vincenti, R., Di Bella, A., Fambrini, M., Fortuna, L., Maltinti, G., Muiesan, P., Petraglia, F., Prosperi, P., Ringressi, M. N., Risaliti, M., Sorbi, F., Taddei, A., Tucci, R., Bassi, C., Bortolasi, L., Campagnaro, T., Casetti, L., De Pastena, M., Esposito, A., Fontana, M., Guglielmi, A., Landoni, L., Malleo, G., Marchegiani, G., Nobile, S., Paiella, S., Pedrazzani, C., Rattizzato, S., Ruzzenente, A., Salvia, R., Turri, G., Tuveri, M., Bellora, P., D'Aloisio, G., Ferrari, M., Francone, E., Gentilli, S., Nikaj, H., Bianchini, M., Chiarugi, M., Coccolini, F., Di Franco, G., Furbetta, N., Gianardi, D., Guadagni, S., Morelli, L., Palmeri, M., Tartaglia, D., Anania, G., Carcoforo, P., Chiozza, M., De Troia, A., Koleva Radica, M., Portinari, M., Sibilla, M. G., Urbani, A., Fabbri, N., Feo, C. V., Gennari, S., Parini, S., Righini, E., Ampollini, L., Bellanti, L., Bergonzani, M., Bertoli, G., Bocchialini, G., D'Angelo, G., Lanfranco, D., Musini, L., Poli, T., Santoro, G. P., Varazzani, A., Aguzzoli, L., Borgonovo, G., Castro Ruiz, C., Coiro, S., Falco, G., Mandato, V. D., Mastrofilippo, V., Montella, M. T., Annessi, V., Zizzo, M., Grossi, U., Novello, S., Romano, M., Rossi, S., Zanus, G., Esposito, G., Frongia, F., Pisanu, A., Podda, M., Belluco, C., Lauretta, A., Montori, G., Moras, L., Olivieri, M., Bussu, F., Carta, A. G., Cossu, M. L., Cottu, P., Fancellu, A., Feo, C. F., Ginesu, G. C., Giuliani, G., Madonia, M., Perra, T., Piras, A., Porcu, A., Rizzo, D., Scanu, A. M., Tedde, A., Tedde, M., Delrio, P., Rega, D., Badalamenti, G., Campisi, G., Cordova, A., Franza, M., Maniaci, G., Rinaldi, G., Toia, F., Calabro, M., Farnesi, F., Lunghi, E. G., Muratore, A., Pipitone Federico, N. S., Bambina, F., D'Andrea, G., Familiari, P., Picotti, V., De Palma, G., Luglio, G., Pagano, G., Tropeano, F. P., Baldari, L., Beltramini, G. A., Boni, L., Cassinotti, E., Gianni, A., Pignataro, L., Torretta, S., Abatini, C., Baia, M., Biasoni, D., Bogani, G., Cadenelli, P., Cioffi, S. P. B., Citterio, D., Comini, L. V., Cosimelli, M., Folli, S., Gennaro, M., Giannini, L., Gronchi, A., Guaglio, M., Macchi, A., Martinelli, F., Mazzaferro, V., Mosca, A., Pasquali, S., Piazza, C., Raspagliesi, F., Rolli, L., Salvioni, R., Sarpietro, G., Sarre, C., Sorrentino, L., Agnes, A., Alfieri, S., Belia, F., Biondi, A., Cozza, V., D'Amore, A., D'Ugo, D., De Simone, V., Fagotti, A., Gasparini, G., Gordini, L., Litta, F., Lombardi, C. P., Lorenzon, L., Marra, A. A., Marzi, F., Moro, A., Parello, A., Perrone, E., Persiani, R., Ratto, C., Rosa, F., Saponaro, G., Scambia, G., Scrima, O., Sganga, G., Tudisco, R., Belli, A., Granata, V., Izzo, F., Palaia, R., Patrone, R., Carrano, F. M., Carvello, M. M., De Virgilio, A., Di Candido, F., Ferreli, F., Gaino, F., Mercante, G., Rossi, V., Spinelli, A., Spriano, G., Donati, D. M., Frisoni, T., Palmerini, E., Aprile, A., Barra, F., Batistotti, P., Ferrero, S., Fregatti, P., Scabini, S., Sparavigna, M., Asti, E., Bernardi, D., Bonavina, L., Lovece, A., Adamoli, L., Ansarin, M., Cenciarelli, S., Chu, F., De Berardinis, R., Fumagalli Romario, U., Mastrilli, F., Pietrobon, G., Tagliabue, M., Badellino, E., Ferrero, A., Massobrio, R., De Manzoni Garberini, A., Federico, P., Maida, P., Marra, E., Marte, G., Petrillo, A., Tammaro, T., Tufo, A., Berselli, M., Borroni, G., Cocozza, E., Conti, L., Desio, M., Livraghi, L., Quintodei, V., Rizzi, A., Zullo, A., Baldi, C., Corbellini, C., Sampietro, G. M., Cellerino, P., Baldini, E., Capelli, P., Isolani, S. M., Ribolla, M., Bondurri, A., Colombo, F., Ferrario, L., Guerci, C., Maffioli, A., Armao, T., Ballabio, M., Bisagni, P., Gagliano, A., Longhi, M., Madonini, M., Pizzini, P., Baietti, A. M., Biasini, M., Maremonti, P., Neri, F., Prucher, G. M., Ricci, S., Ruggiero, F., Zarabini, A. G., Barmasse, R., Mochet, S., Usai, A., Incollingo, P., Mancini, S., Marino Cosentino, L., Sagnotta, A., Fruscio, R., Grassi, T., Nespoli, L. C., Tamini, N., Anastasi, A., Bartalucci, B., Bellacci, A., Canonico, G., Capezzuoli, L., Di Martino, C., Ipponi, P., Linari, C., Montelatici, M., Nelli, T., Spagni, G., Tirloni, L., Vitali, A., Abate, E., Casati, M., Casiraghi, T., Laface, L., Schiavo, M., Arminio, A., Cotoia, A., Lizzi, V., Vovola, F., Vergari, R., D'Ugo, S., Depalma, N., Spampinato, M. G., Bartolucci, P., Brachini, G., Bruzzaniti, P., Chiappini, A., Chiarella, V., Ciccarone, F., Cicerchia, P. M., Cirillo, B., De Toma, G., Di bartolomeo, A., Fiori, E., Fonsi, G. B., Franco, G., Frati, A., Giugliano, M., Iannone, I., La Torre, F., Lapolla, P., Leonardo, C., Marruzzo, G., Meneghini, S., Mingoli, A., Ribuffo, D., Salvati, M., Santoro, A., Sapienza, P., Scafa, A. K., Simonelli, L., Zambon, M., Capolupo, G. T., Carannante, F., Caricato, M., Masciana, G., Mazzotta, E., Gattolin, A., Migliore, M., Rimonda, R., Sasia, D., Travaglio, E., Cervellera, M., Gori, A., Sartarelli, L., Tonini, V., Giacometti, M., Zonta, S., Chessa, A., Fiorini, A., Norcini, C., Colletti, G., Confalonieri, M., Costanzi, A., Frattaruolo, C., Mari, G., Monteleone, M., Bandiera, A., Bocciolone, L., Bonavina, G., Candiani, M., Candotti, G., De Nardi, P., Gagliardi, F., Medone, M., Mortini, P., Negri, G., Parise, P., Piloni, M., Sileri, P., Vignali, A., Belvedere, A., Bernante, P., Bertoglio, P., Boussedra, S., Brunocilla, E., Cipriani, R., Cisternino, G., De Crescenzo, E., De Iaco, P., Dondi, G., Frio, F., Jovine, E., Mineo Bianchi, F., Neri, J., Parlanti, D., Perrone, A. M., Pezzuto, A. P., Pignatti, M., Pinto, V., Poggioli, G., Ravaioli, M., Rottoli, M., Schiavina, R., Serenari, M., Serra, M., Solli, P., Taffurelli, M., Tanzanu, M., Tesei, M., Violante, T., Zanotti, S., Borghi, F., Cianflocca, D., Di Maria Grimaldi, S., Gelarda, E., Geretto, P., Giraudo, G., Giuffrida, M. C., Marano, A., Palagi, S., Pellegrino, L., Peluso, C., Testa, V., Agresta, F., Prando, D., Zese, M., Aquila, F., Gambacciani, C., Lippa, L., Pieri, F., Santonocito, O. S., Armatura, G., Bertelli, G., Frena, A., Marinello, P., Notte, F., Patauner, S., Scotton, G., Fulginiti, S. F., Gallo, G., Sammarco, G., Vescio, G., Balercia, P., Catarzi, L., Consorti, G., Di Marzo, F., Fontana, T., Daiko, H., Ishikawa, M., Ishiyama, K., Iwata, S., Kanematsu, K., Kanemitsu, Y., Kato, T., Kawai, A., Kobayashi, E., Kobayashi Kato, M., Moritani, K., Nakatani, F., Oguma, J., Tanase, Y., Uno, M., Al Abdallah, M., Ayasra, F., Ayasra, Y., Qasem, A., Abu Za'nouneh, F. J., Fahmawee, T., Hmedat, A., Ibrahim, A., Obeidat, K., Abdel Al, S., Abdel Jalil, R., Abou Chaar, M. K., Al-Masri, M., Al-Najjar, H., Alawneh, F., Alsaraireh, O., Elayyan, M., Ghanem, R., Lataifeh, I., Alkadeeki, G. Z., Al Maadany, F. S., Aldokali, N., Senossi, O., Subhi, M. T., Burgan, D., Kamoka, E., Kilani, A. I., Salamah, A., Salem, M., Shuwayyah, A., Abdulwahed, E., Alshareea, E., Aribi, N., Aribi, S., Biala, M., Ghamgh, R., Morgom, M., Aldayri, Z., Ellojli, I., Kredan, A., Bradulskis, S., Dainius, E., Kubiliute, E., Kutkevicius, J., Parseliunas, A., Subocius, A., Venskutonis, D., Rasoaherinomenjanahary, F., Razafindrahita, J. B., Samison, L. H., Ong, E. C., Hamdan, K. H., Ibrahim, M. R., Tan, J. A., Thanapal, M. R., Amin Sahid, N., Hayati, F., Jayasilan, J., Sriram, R. K., Subramaniam, S., Che Jusoh, A., Hussain, A. H., Mohamed Sidek, A. S., Mohd Yunus, M. F., Soh, J. Y., Wong, M. P. K., Zakaria, A. D., Zakaria, Z., Fadzli, A., Fathi, N. Q., Koh, P. S., Liew, Y. T., Roslani, A. C., Tang, C. Y., Teoh, L. Y., Wong, W. J., Yahaya, A. S., Alvarez, M. R., Arrangoiz, R., Cordera, F., De La Rosa Abaroa, M. A., Gomez-Pedraza, A., Hernandez, R., Maffuz-Aziz, A., Posada, J. A., Becerra Garcia, F. C., Alfaro-Goldaracena, A., Buerba, G. A., Castillejos-Molina, R. A., Chan, C., Dominguez-Rosado, I., Medina-Franco, H., Mercado, M. A., Oropeza-Aguilar, M., Pena Gomez Portugal, E., Posadas-Trujillo, O. E., Rodriguez-Covarrubias, F., Salgado-Nesme, N., Vilatoba, M., Arkha, Y., Bechri, H., El Ouahabi, A., Oudrhiri, M. Y., Derkaoui hassani, F., El Abbadi, N., Amrani, L., Belkhadir, Z. H., Benkabbou, A., Chakib, O., El Ahmadi, B., El Bouazizi, Y., Essangri, H., Ghannam, A., Majbar, A. M., Mohsine, R., Souadka, A., Hompes, R., Meima-Van Praag, E. M., Pronk, A. J. M., Sharabiany, S., Grotenhuis, B., Hartveld, L., Reijers, S., Van Houdt, W., Baaij, J., Bolster-Van Eenennaam, M., De Graaff, M., Sloothaak, D., Van Duijvendijk, P., Posma-Bouman, L., Derksen, T., Franken, J., Oosterling, S., De Bree, R., Konsten, J., Van Heinsbergen, M., Fidelis, L., Sholadoye, T. T., Tolani, M. A., Olaogun, J., Egbuchulem, I. K., Lawal, T. A., Ogundoyin, O., Olulana, D. I., Abdur-Rahman, L., Adeyeye, A., Aremu, I., Bello, J., Olasehinde, O., Popoola, A., Massoud, J., Massoud, R., Sorour, T. M., Jamal, A., Kerawala, A. A., Memon, A. S., Nafees Ahmed, R., Rai, L., Ayub, B., Hassan, N., Martins, R. S., Ramesh, P., Sayyed, R., Butt, U., Kashif, M., Khan, W. H., Qureshi, A., Umar, M., Waris Farooka, M., Wasim, T., Ayubi, A., Rashid, I., Waqar, S. H., Falcon, G. M., Robles, R., Jocson, R., Teh, C., Major, P., Bobinski, M., Kotarski, J., Rasoul-Pelinska, K., Azevedo, C., Machado, D., Mendes, F., De Sousa, X., Fernandes, U., Ferreira, C., Guidi, G., Leal, C., Marcal, A., Marques, R., Martins, D., Melo, A., Tenreiro, N., Vaz Pereira, R., Vieira, B., Almeida, J. I., Correia de Sa, T., Costa, M. J. M. A., Fernandes, V., Ferraz, I., Gil, C. G., Lima Da Silva, C., Lopes, L., Machado, N., Marialva, J., Nunes Coelho, M., Pedro, J., Pereira, C., Reis, R., Ribeiro, A., Santos, R., Saraiva, P., Silva, R., Tavares, F., Teixeira, M., Almeida, A. C., Amaral, M. J., Andrade, R., Athayde Nemesio, R., Breda, D., Camacho, C., Canhoto, C., Colino, M., Correia, S., De Barros, J., De Oliveira Lopez, A. L., Duque, M., Garrido, S., Guerreiro, P., Guimaraes, A., Lazaro, A., Lopes, C., Nogueira, O., Oliveira, A., Oliveira, J. M., Rodrigues, M., Ruivo, A., Santos, E., Silva, M., Simoes, J., Valente Da Costa, A., Almeida, A., Cavaleiro, S., Devezas, V., Faria, C. S., Jacome, F., Magalhaes Maia, M., Nogueiro, J., Pereira, A., Pereira-Neves, A., Pina-Vaz, T., Santos-Sousa, H., Silveira, H., Vaz, S., Vieira, P., Gomes Da Costa, A., Lobo Antunes, I., Pinto, J., Tojal, A., Cardoso, N., Cardoso, P., Domingues, J. C., Henriques, P., Manso, M. I., Martins Dos Santos, G., Morais, H., Pereira, R., Revez, T., Ribeiro, R., Ribeiro, V. I., Sousa, S., Teixeira, J., Amorim, E., Baptista, V. H., Cunha, M. F., Dias, B., Fazenda, A., Melo Neves, J. P., Policarpo, F., Sampaio Da Novoa Gomes Miguel, I. I., Veiga, D., Andrade, A. K., Bandovas, J. P., Borges, N., Branquinho, A., Chumbinho, B., Correia, J., Fidalgo, H., Figueiredo De Barros, I., Frade, S., Gomes, J., Maciel, J., Pina, S., Rodrigues, A., Silva, N., Silveira Nunes, I., Sousa, R., Ascensao, J., Azevedo, P., Costeira, B., Cunha, C., Garrido, R., Gomes, H., Lourenco, I., Mendinhos, G., Miranda, P., Nobre Pinto, A., Peralta Ferreira, M., Ribeiro, J., Rio Rodrigues, L., Sousa Fernandes, M., Azevedo, J., Galvao, D., Soares, A. C., Vieira, A., Patricio, B., Santos, P. M. D. D., Vieira Paiva Lopes, A. C., Cunha, R., Faustino, A., Freitas, A., Martins, A. B., Mendes, J. R., Parreira, R., Rosa, J., Teves, M., Abreu Da Silva, A., Claro, M., Costa Santos, D., Deus, A. C., Grilo, J. V., Borges, F., Corte Real, J., Henriques, S., Lima, M. J., Matos Costa, P., Brito da Silva, F., Caiado, A., Fonseca, F., Angelo, M., Baiao, J. M., Martins Jordao, D., Vieira Caroco, T., Messias, J., Millan, A., Salgado, I., Baia, C., Canotilho, R., Correia, A. M., Ferreira Pinto, A. P., Peyroteo, M., Videira, J. F., Escobar, P., Maldonado Santiago, M., Kassir, R., Sauvat, F., Bezede, C., Chitul, A., Ciofic, E., Cristian, D., Grama, F., Pirtea, L., Secosan, C., Bonci, E., Gata, V., Titu, S., Ginghina, O., Iordache, N., Iosifescu, R. V., Garmanova, T., Kazachenko, E., Markaryan, D., Rodimov, S., Tsarkov, P., Tulina, I., Litvina, Y., Provozina, A., Agapov, M., Galliamov, E., Kakotkin, V., Kubyshkin, V., Alshahrani, M., Alsharif, F., Eskander, M., Al Raddadi, R., Majrashi, S., Mashat, A., Akeel, N., Alharthi, M., Aljiffry, M., Basendowah, M., Farsi, A., Ghunaim, M., Khoja, A., Maghrabi, A., Malibary, N., Nassif, M., Nawawi, A., Saleem, A., Samkari, A., Trabulsi, N., Al Awwad, S., Alghamdi, M., Alnumani, T., Nasser, M., Said bayazeed, A., Alhefdhi, A., Almalik, O., Alomair, A., Alotaibi, N., Alresaini, F., Alsalamah, R., Alsobhi, S., Mahasin, Z., Othman, E., Velagapudi, S., Ghedan, S., Alharthi, R., Awad, S., Sharara, M., Abdelrahman, S., Althobaiti, W., Al Habes, H., Alamri, A., Alkarak, S., Alqannas, M., Alyami, M., Alzamanan, M., Cortes Guiral, D., Elawad, A., Alaamer, O., Alriyees, L., Alselaim, N., Abdulkareem, A., Ajlan, A., Akkour, K., Al-Habib, A., Al-Khayal, K., Alatar, A., Alburakan, A., Alhalal, H., Alhassan, B., Alhassan, N., Alobeed, O., Alsaif, A., Alsaif, F., Alshammari, S., Alshaygy, I., Barry, M., Bin Nasser, A., Bin Traiki, T., Bokhari, A., Elwatidy, S., Helmi, H., Madkhali, A., Nouh, T., Rabah, P. D., Zubaidi, A., Paunovic, I., Slijepcevic, N., Aleksic, L., Antic, A., Barisic, G., Ceranic, M., Galun, D., Grubac, Z., Jelenkovic, J., Kecmanovic, D., Kmezic, S., Knezevic, D., Krivokapic, Z., Latincic, S., Markovic, V., Matic, S., Miladinov, M., Pavlov, M., Pejovic, I., Radenkovic, D., Tadic, B., Vasljevic, J., Velickovic, D., Zivanovic, M., Perovic, M., Srbinovic, L., Andrijasevic, S., Bozanovic, T., Cerovic Popovic, R., Dokic, M., Janjic, T., Jeremic, K., Kadija, S., Ladjevic Likic, I., Mirkovic, L., Pantovic, S., Pilic, I., Radojevic, M., Stefanovic, A., Vidakovic, S., Vilendecic, Z., Antic, S., Dunderovic, D., Jelovac, D., Jezdic, Z., Konstantinovic, V., Kotlar, B., Kuzmanovic, C., Lazic, M., Petrovic, M., Popovic, F., Pucar, A., Romic, M., Sumrak, S., Vujanac, V., Bascarevic, V., Bogdanovic, I., Grujicic, D., Ilic, R., Milicevic, M., Milisavljevic, F., Miljkovic, A., Paunovic, A., Scepanovic, V., Stanimirovic, A., Todorovic, M., Jotic, A., Milovanovic, J., Trivic, A., Bumbasirevic, U., Dzamic, Z., Kajmakovic, B., Prijovic, N., Zivkovic, M., Buta, M., Cvetkovic, A., Djurisic, I., Gacic, S., Goran, M., Inic, Z., Jeftic, N., Jevric, M., Jokic, V., Markovic, I., Milanovic, M., Nikolic, S., Pejnovic, L., Savkovic, N., Spurnic, I., Stevic, D., Stojiljkovic, D., Vucic, N., Zegarac, M., Karamarkovic, A., Kenic, M., Kovacevic, B., Krdzic, I., Milutinovic, V., Lieske, B., Galis, B., Simko, K., Almgla, N., Bernon, M., Boutall, A., Cairncross, L., Herman, A., Hilton, T., Jonas, E., Kloppers, C., Malherbe, F., Mugla, W., Nel, D., Rayamajhi, S., Van Wyngaard, T., Vogel, J., Castano-Leon, A. M., Delgado Fernandez, J., Eiriz Fernandez, C., Espino Segura-Illa, M., Esteban Sinovas, O., Garcia Perez, D., Gomez, P., Jimenez-Roldan, L., Lagares, A., Moreno-Gomez, L., Paredes, I., Perez Nunez, A., Sanchez Aniceto, G., Santas, M., Fernandez Rodriguez, P., Paniagua Garcia Senorans, M., Sanchez-Santos, R., Vigorita, V., Acrich, E., Baena Sanfeliu, E., Barrios, O., Golda, T., Santanach, C., Serrano-Navidad, M., Sorribas Grifell, M., Vives, R. V., Escola, D., Jimenez, A., Cayetano Paniagua, L., Gomez Fernandez, L., Artigues, E., Bernal-Sprekelsen, J. C., Catala Bauset, J. C., Collera, P., Diaz Del Gobbo, R., Farre Font, R., Flores Clotet, R., Gomez Diaz, C. J., Guardia, N., Guariglia, C. A., Osorio, A., Sanchez Jimenez, R., Sanchon, L., Soto Montesinos, C., Albi Martin, B., Garcia Villayzan, J. E., Alonso-Lamberti, L., Assaf, M., Baeza Pintado, N., Carabias, A., Garcia-Quijada, J., Huertas Fernandez, M. A., Jimenez Miramon, J., Jimenez, V., Jover, J. M., Landeo Aguero, S. A., Leon, R., Martin Salamanca, M. B., Perez Simon, V., Ponce, S., Rodriguez, J. L., Salazar, A., Valle Rubio, A., Aguado, H., Aldecoa Ansorregui, I., Bravo Infante, R., De Lacy, F. B., Di Somma, A., Diaz-Feijoo, B., Ensenat Nora, J., Fabregas, N., Ferres, A., Gil Ibanez, B., Gonzalez Sanchez, J. J., Gracia, I., Hoyos Castro, J. A., Lacy, A. M., Langdon, C., Momblan, D., Morales, X., Oleaga, L., Otero, A., Pedrosa, L., Poblete Carrizo, J., Reyes Figueroa, L. A., Roldan Ramos, P., Rumia-Arboix, J., Tercero-Uribe, A. I., Topczewski, T. E., Torales, J., Torne, A., Torne, R., Turrado-Rodriguez, V., Valero, R., Valverde, S., Anula, R., Cano-Valderrama, O., Del Campo Martin, M., Diez-Valladares, L., Dominguez, I., Dziakova, J., Garcia Alonso, M., Garcia Romero, E., Gomez Latorre, L., Muguerza, J. M., Pizarro, M. J., Saez Carlin, P., Sanchez Del Pueblo, C., Sanchez-Pernaute, A., Sanz Ortega, G., Sanz-Lopez, R., Torres, A., Garces-Albir, M., Lopez, F., Martin-Arevalo, J., Moro-Valdezate, D., Pla-Marti, V., Beltran De Heredia, J., De Andres Asenjo, B., Gomez Sanz, T., Jezieniecki, C., Nunez Del Barrio, H., Ortiz De Solorzano Aurusa, F. J., Romero De Diego, A., Ruiz Soriano, M., Trujillo Diaz, J., Vazquez Fernandez, A., Lora-Cumplido, P., Sosa, M. V., Gonzalez-Gonzalez, E., Minaya Bravo, A. M., Alonso de la Fuente, N., Cazador Labat, M., Cecchini, L., Espinosa, C. A., Jimenez Toscano, M., Lopez Campillo, A., Mancebo, G., Martorell, P., Munarriz, M., Grau-Talens, E. J., Martin-Perez, B., Benavides Buleje, J. A., Carrasco Prats, M., Fernandez, P. V., Fernandez-Lopez, A., Garcia Escudero, D., Garcia Porcel, V. J., Garcia Soria, V., Gimenez Frances, C., Gonzalez Valverde, F. M., Gurrea, E., Lopez-Morales, P., Marco Garrido, A., Martinez Alonso, J. A., Medina, E., Munoz Camarena, J. M., Parra Banos, P. A., Pena Ros, E., Ramirez Faraco, M., Ruiz-Marin, M., Sanchez Rodriguez, C., Valero Soriano, M., Estaire Gomez, M., Fernandez Camunas, A., Garcia Santos, E. P., Jimenez Higuera, E., Martinez-Pinedo, C., Munoz-Atienza, V., Padilla-Valverde, D., Picon Rodriguez, R., Redondo Calvo, F. J., Sanchez-Garcia, S., Sanchez-Pelaez, D., Colombari, R. C., Del valle, E., Fernandez, M., Lozano Lominchar, P., Rey Valcarcel, C., Steiner, M. A., Tudela, M., Zorrilla Ortuzar, J., Alcaide Matas, F., Garcia Perez, J. M., Troncoso Pereira, P., Mora-Guzman, I., Abellan, M., Achalandabaso Boira, M., Jorba, R., Memba Ikuga, R., Olona, C., Sales Mallafre, R., Cavalle Busquets, P., Gavalda Pellice, M. G. P., Salinas Pena, J., Aragon Achig, E. J., Barbier, L., Caja Vivancos, P., Gainza, A., Garcia Gutierrez, J. J., Mallabiabarrena Ormaechea, G., Marin, H., Martin Playa, P., Melchor Corcostegui, I., Prieto Calvo, M., Rodriguez Fraga, A., Villalabeitia Ateca, I., De Andres Olabarria, U., Duran Ballesteros, M., Fernandez Pablos, F. J., Ibanez-Aguirre, F. J., Sanz Larrainzar, A., Ugarte-Sierra, B., De La Hoz Rodriguez, A., Di Martino, M., Garcia Septiem, J., Martin-Perez, E., Munoz De Nova, J. L., Calvo Espino, P., Guillamot Ruano, P., Colao Garcia, L., Diaz Perez, D., Esteban Agusti, E., Galindo Jara, P., Gutierrez Samaniego, M., Hernandez Bartolome, M. A., Serrano Gonzalez, J., Alonso Poza, A., Dieguez, B., Garcia-Conde, M., Hernandez-Garcia, M., Losada, M., Chiesa-Estomba, C. M., Gonzalez Garcia, J. A., Larruscain, E., Sistiaga-Suarez, J. A., Alvarez, E., Chavarrias, N., Frias, L., Garcia Pineda, V., Gegundez Simon, A., Gortazar, S., Gracia, M., Guevara, J., Hernandez Gutierrez, A., Loayza, A., Maria Dolores, D. T., Marti, C., Melendez, M., Moreno-Palacios, E., Perez, Y., Prieto Nieto, M. I., Ramos-Martin, P., Rubio-Perez, I., Saavedra, J., Sanchez-Mendez, J. I., Siegrist Ridruejo, J., Urbieta, A., Zapardiel, I., Cantalejo diaz, M., De Miguel Ardevines, M. D. C., Duque-Mallen, V., Gascon Ferrer, I., Gonzalez-Nicolas Trebol, M. T., Gracia-Roche, C., Herrero Lopez, M., Jariod Ferrer, U. M., Lanzon, A., Martinez German, A., Matute, M., Redondo, C., Sanchez Fuentes, N., Sanchez-Rubio, M., Santero-Ramirez, M. S., Saudi, S., Simon Sanz, M. V., Uson-Bouthelier, T., Blazquez Martin, A., Diez Alonso, M., Garcia Rico, E., Garcia-Loarte Gomez, E., Garcia-Moreno Nisa, F., Gutierrez Calvo, A., Hernandez, P., Lasa, I., Mendoza-Moreno, F., Morales Palacios, N., Ovejero Merino, E., Vera Mansilla, C., Acebes Garcia, F., Bailon, M., Bueno Canones, A. D., Choolani Bhojwani, E., Marcos-Santos, P., Miguel, T., Pacheco Sanchez, D., Perez-Saborido, B., Sanchez Gonzalez, J., Tejero-Pintor, F. J., Alconchel, F., Conesa, A., Gil Martinez, J., Gutierrez Fernandez, A. I., Lopez Abad, A., Nicolas-Lopez, T., Ramirez Romero, P., Roca Calvo, M. J., Rodrigues, K., Ruiz Manzanera, J. J., Soriano, A. I., Cano, A., Capitan-Morales, L., Cintas Catena, J., Gomez-Rosado, J., Oliva Mompean, F., Perez Sanchez, M. A., Rio Lafuente, F. D., Torres Arcos, C., Valdes-Hernandez, J., Cholewa, H., Domingo, S., Frasson, M., Lago, V., Marina Martin, T., Martinez Chicote, C., Sancho-Muriel, J., Landaluce-Olavarria, A., Lecumberri, D., Abad Gurumeta, A., Abad-Motos, A., Martinez-Hurtado, E., Ripolles-Melchor, J., Ruiz Escobar, A., Cuadrado-Garcia, A., Garcia-Sancho Tellez, L., Heras Aznar, J., Mate, P., Ortega Vazquez, I., Picardo, A. L., Rojo Lopez, J. A., Sanchez Cabezudo Noguera, F., Serralta De Colsa, D., Anchuelo Latorre, J., Cagigas Fernandez, C., Caina Ruiz, R., Gomez Ruiz, M., Hernanz, F., Jimeno Fraile, J., Martinez-Perez, P., Poch, C., Santarrufina Martinez, S., Valbuena Jabares, V., Moliner-Sanchez, C., Pingarron-Martin, L., Rey-Biel, J., Ruiz Martin, I., Blas Laina, J. L., Cros, B., Escartin, J., Garcia Egea, J., Nogues, A., Talal El-Abur, I., Yanez, C., Cagigal Ortega, E. P., Cervera, I., Diaz Pena, P., Elena, G. D. C. R., Enjuto, D., Fernandez Bernabe, P., Garces Garcia, R., Gonzalez, J., Hernandez, I., Herrera-Merino, N., Marqueta De Salas, M., Martinez Pascual, P., Perez Gonzalez, M., Ramos Bonilla, A., Rodriguez Gomez, L., Bescos, C., Blanco-Colino, R., Brana, I., Caimari, B., De Pablo Garcia-Cuenca, A., Duran-Valles, F., Espin-Basany, E., Giralt Lopez De Sagredo, J., Pamias, J., Pellino, G., Prat, N., Pujol Pina, R., Saez Barba, M., Arulanantham, A., Bandara, G. B. K., Jayarajah, U., Ravindrakumar, S., Rodrigo, V. S., Srishankar, S., Ali Karar, A. A., Elbe, P., Lindqvist, E. K., Taflin, H., Alga, A., Heinius, G., Nordberg, M., Pieniowski, E., Gkekas, I., Lofgren, N., Rutegard, M., Sund, M., Arigoni, M., Bernasconi, M., Christoforidis, D., Di Giuseppe, M., La Regina, D., Mongelli, F., Chevallay, M., Dwidar, O., Gialamas, E., Sauvain, M., Klenke, F., Kollar, A., Kurze, C., Adamina, M., Bachler, T., Crugnale, A. S., Giardini, M., Guglielmetti, L., Peros, G., Solimene, F., Aghayeva, A., Hamzaoglu, I., Sahin, I., Akaydin, E., Aliyeva, Z., Aytac, E., Baca, B., Dulgeroglu, O., Ozben, V., Ozmen, B. B., Uras, C., Arikan, A. E., Bilgin, I. A., Bozkirli, B., Ceyhan, G. O., Kara, H., Karahasanoglu, T., Celik, H., Meydanli, M. M., Akilli, H., Ayhan, A., Kuscu, E., Onan, M. A., Akgor, U., Dincer, H. A., Erol, T., Gultekin, M., Orhan, N., Ozgul, N., Salman, M. C., Soyak, B., Alhamed, A., Ergun, S., Ozcelik, M. F., Sanli, A. N., Uludag, S. S., Velidedeoglu, M., Zengin, A. K., Bozkurt, M. A., Kara, Y., Kocatas, A., Cimenoglu, B., Demirhan, R., Saracoglu, K., Azamat, I. F., Balik, E., Bugra, D., Giray, B., Kulle, C. B., Taskiran, C., Vatansever, D., Gozal, K., Guler, S. A., Koken, H., Tatar, O. C., Utkan, N. Z., Yildirim, A., Yuksel, E., Akin, E., Altintoprak, F., Bayhan, Z., Cakmak, G., Capoglu, R., Celebi, F., Demir, H., Dikicier, E., Firat, N., Gonullu, E., Kamburoglu, M. B., Kocer, B., Kucuk, I. F., Mantoglu, B., Colak, E., Kucuk, G. O., Uyanik, M. S., Goksoy, B., Bozkurt, E., Citgez, B., Mihmanli, M., Tanal, M., Yetkin, G., Akalin, M., Arican, C., Avci, E. K., Aydin, C., Demirli Atici, S., Emiroglu, M., Kaya, T., Kebabci, E., Kilinc, G., Kirmizi, Y., Ogucu, H., Salimoglu, S., Sert, I., Tugmen, C., Tuncer, K., Uslu, G., Yesilyurt, D., Karaman, E., Kolusari, A., Yildiz, A., Benson, O., Lule, H., Agilinko, J., Ahmeidat, A., Barabasz, M., Bekheit, M., Cheung, L. K., Colloc, T., Cymes, W., Elhusseini, M., Gradinariu, G., Hannah, A., Kamera, B. S., Mignot, G., Shaikh, S., Sharma, P., Abu-Nayla, I., Agrawal, A., Al-Mohammad, A., Ali, S., Ashcroft, J., Azizi, A., Baker, O., Balakrishnan, A., Byrne, M., Colquhoun, A., Cotter, A., Coughlin, P., Davies, R. J., Durrani, A., Elshaer, M., Fordington, S., Forouhi, P., Georgiades, F., Grimes, H., Habeeb, A., Hudson, V., Hutchinson, P., Irune, E., Jah, A., Khan, D. Z., Kyriacou, H., Lamb, B., Liau, S., Luke, L., Mahmoud, R., Mannion, R., Masterson, L., Mitrofan, C. G., Mohan, M., Morris, A., Murphy, S., O'Neill, R., Price, S., Pushpa-Rajah, J., Raby-Smith, W., Ramzi, J., Rooney, S., Santarius, T., Singh, A., Tan, X. S., Townson, A., Tweedle, E., Walker, C., Waseem, S., Yordanov, S., Jones, T., Kattakayam, A., Loh, C., Lunevicius, R., Pringle, S., Schache, A., Sheel, A., Rossborough, C., Angelou, D., Choynowski, M., Mcaree, B., Mccanny, A., Neely, D., Tutoveanu, G., Ahad, S., De La Cruz Monroy, M. F. I., Mosley, F., Oktseloglou, V., Alanbuki, A., Patel, M., Shabana, A., Perera, E., Raveendran, D., Ravi-Shankar, K., Thiruchelvam, J., Arrowsmith, L., Campbell, W., Grove, T., Kontovounisios, C., Warren, O., Rolland, P., Aggarwal, A., Brown, S., Jelley, C., Neal, N., Clifford, R., Eardley, N., Krishnan, E., Manu, N., Martin, E., Roy Mahapatra, S., Serevina, O. L., Smith, C., Vimalachandran, D., Bordenave, M., Houston, R., Putnam, G., Robson, A., Tustin, H., Emslie, K., Labib, P. L., Marchbank, A., Miller, D., Minto, G., Natale, J., Nwinee, H., Panahi, P., Rogers, L., Abubakar, A., Akhter Rahman, M. M., Ko, K. Y. K., O'Brien, H., Sasapu, K., Woodun, H., Inglis, R., Ng, H. J., De Gea Rico, A., Ghazali, N., Lambert, J., Markose, G., Math, S., Sarantitis, I., Shrestha, D., Sultana, A., Taggarsi, M., Timbrell, S., Vaz, O. P., Vitone, L., Day, A., Dent, H., Fahim, M., Waheed, S., Hunt, A., Laskar, N., Gupta, A., Steinke, J., Thrumurthy, S., Massie, E., Mcgivern, K., Rutherford, D., Wilson, M., Hardie, J., Kazzaz, S., Handa, S., Kaushal, M., Kler, A., Patel, P., Redfern, J., Tezas, S., Aawsaj, Y., Amonkar, S., Blackwell, L., Blake, D., Carter, J., Emerson, H., Fisher, A., Katory, M., Korompelis, P., Mccormick, W., Mustafa, A., Pearce, L., Ratnavelu, N., Reehal, R., Kretzmer, L., Lalou, L., Manku, B., Parwaiz, I., Stafford, J., Abdelkarim, M., Asqalan, A., Gala, T., Ibrahim, S., Maw, A., Mithany, R., Morgan, R., Sundaram Venkatesan, G., Ang, K., Caruana, E. J., Chowdhry, M. F., Mohammad, A., Nakas, A., Rathinam, S., Boal, M., Brown, O., Dwerryhouse, S., Higgs, S., Vallance, A., Boyd, E., Irvine, V., Kirk, A., Bakolas, G., Boulton, A., Chandock, A., Khan, T., Kumar, M., Agoston, P., Bille, A., Challacombe, B., Fraser, S., Harrison-Phipps, K., King, J., Mehra, G., Mills, L., Najdy, M., Nath, R., Okiror, L., Pilling, J., Rizzo, V., Routledge, T., Sayasneh, A., Stroman, L., Wali, A., Fehervari, M., Fotopoulou, C., Habib, N., Hamrang-Yousefi, S., Jawad, Z., Jiao, L., Pai, M., Ploski, J., Rajagopal, P., Saso, S., Sodergren, M., Spalding, D., Laws, S., Hardie, C., Mcnaught, C., Alam, R., Budacan, A., Cahill, J., Kalkat, M., Karandikar, S., Kenyon, L., Naumann, D., Patel, A., Ayorinde, J., Chase, T., Cuming, T., Ghanbari, A., Humphreys, L., Tayeh, S., Aboelkassem Ibrahim, A., Bichoo, R., Cao, H., Chai, A. K. W., Choudhury, J., Evans, C., Fitzjohn, H., Ikram, H., Langstroth, M., Loubani, M., Mcmillan, A., Nazir, S., Qadri, S. S. A., Robinson, A., Ross, E., Sehgal, T., Wilkins, A., Dixon, J., Dunning, J., Freystaetter, K., Jha, M., Lester, S., Madhavan, A., Thulasiraman, S. V., Viswanath, Y., Curl-Roper, T., Delimpalta, C., Liao, C. C. L., Velchuru, V., Westwood, E., Belcher, E., Bond-Smith, G., Chidambaram, S., Di Chiara, F., Fasanmade, K., Fraser, L., Fu, H., Ganau, M., Gore, S., Graystone, J., Jeyaretna, D., Khatkar, H., Lami, M., Maher, M., Mastoridis, S., Mihai, R., Piper, R., Prabhu, S., Risk, O. B. F., Selbong, U., Shah, K., Smillie, R., Soleymani majd, H., Sravanam, S., Stavroulias, D., Tebala, G. D., Vatish, M., Verberne, C., Wallwork, K., Winter, S., Bhatti, M. I., Boyd-Carson, H., Elsey, E., Gemmill, E., Herrod, P., Jibreel, M., Lenzi, E., Saafan, T., Sapre, D., Sian, T., Watson, N., Athanasiou, A., Bourke, G., Bradshaw, L., Brunelli, A., Burke, J., Coe, P., Costigan, F., Elkadi, H., Johnstone, J., Kanatas, A., Kantola, V., Kaufmann, A., Laios, A., Lam, S., Macinnes, E., Munot, S., Nahm, C., Otify, M., Pompili, C., Smith, I., Theophilou, G., Toogood, G., Wade, R., Ward, D., West, C., Annamalai, S., Ashmore, C., Boddy, A., Hossain, T., Kourdouli, A., Gvaramadze, A., Jibril, A., Prusty, L., Thekkinkattil, D., Harky, A., Shackcloth, M., Askari, A., Cirocchi, N., Kudchadkar, S., Patel, K., Sagar, J., Shaw, S., Talwar, R., Abdalla, M., Edmondson, R., Ismail, O., Jones, D., Newton, K., Stylianides, N., Aderombi, A., Andaleeb, U., Bajomo, O., Beatson, K., Garrett, W., Mehmood, M., Ng, V., Al-Habsi, R., Divya, G. S., Keeler, B., Al-Sarireh, B., Egan, R., Harries, R., Henry, A., Kittur, M., Li, Z., Parkins, K., Soliman, F., Spencer, N., Thompson, D., Burgess, C., Gemmell, C., Grieco, C., Hollyman, M., Hunt, L., Morrison, J., Ojha, S., Ryan, N., Abbadessa, F., Barnard, S., Dawe, N., Hammond, J., Mahmoud Ali, F., Mcpherson, I., Mellor, C., Moir, J., Pandanaboyana, S., Powell, J., Rai, B., Roy, C., Sachdeva, A., Saleh, C., Tingle, S., Williams, T., Manickavasagam, J., Mcdonald, C., Mcgrath, N., Mcsorley, N., Ragupathy, K., Ramsay, L., Solth, A., Kakisi, O., Seebah, K., Shaikh, I., Sreedharan, L., Youssef, M., Shah, J., Ameerally, P., Mclarty, N., Mills, S., Shenfine, A., Sahnan, K., Abu, J., Addae-Boateng, E., Bratt, D., Brock, L., Burnside, N., Cadwell-Sneath, S., Gajjar, K., Gan, C., Grundy, C., Hallam, K., Hassell, K., Hawari, M., Joshi, A., Khout, H., Konstantinidi, K., Lee, R. X. N., Nunns, D., Schiemer, R., Walton, T., Weaver, H., Whisker, L., Williamson, K., Mcveigh, J., Myatt, R., Williams, M. A., Kaur, R., Leung, E., Michel, M., Patil, S., Ravindran, S., Sarveswaran, J., Scott, L., Edmond, M., King, E., Almond, M., Breik, O., Cato, L. D., Idle, M., Kamal, M., Kisiel, A., Kulkarni, R., Mak, J. K. C., Martin, T., Nankivell, P., Parente, A., Parmar, S., Pathanki, A. M., Phelan, L., Praveen, P., Saeed, S., Sharma, N., Singh, J., Tirotta, F., Vijayan, D., Geddes, A., Mccaul, J., Mcmahon, J., Khan, A. H., Khan, F., Mansuri, A., Mukherjee, S., Sarigul, M., Singh, S., Tan, K. L., Woodham, A., Adiamah, A., Brewer, H., Chowdhury, A., Evans, J., Humes, D., Jackman, J., Koh, A., Lewis-Lloyd, C., Oyende, O., Reilly, J., Worku, D., Cool, P., Cribb, G., Shepherd, K., Bisset, C., Moug, S., Elson, N., Faulkner, G., Saleh, P., Underwood, C., Brixton, G., Findlay, L., Majkowska, A., Manson, J., Potter, R., Bhalla, A., Chia, Z., Daliya, P., Goyal, A., Grimley, E., Hamad, A., Kumar, A., Malcolm, F. L., Theophilidou, E., Bowden, J., Campain, N., Daniels, I., Fowler, G., John, J., Massey, L., Mcdermott, F., Mcgrath, J., Mclennan, A., Ng, M., Pascoe, J., Rajaretnam, N., Bulathsinhala, S., Davidson, B., Fusai, G., Hidalgo Salinas, C., Machairas, N., Pissanou, T., Pollok, J. M., Raptis, D. A., Soggiu, F., Tzerbinis, H., Xyda, S. E., Beamish, A., Davies, E., Foulkes, R., Magowan, D., Nassa, H., Ooi, R., Price, C., Solari, F., Tang, A., Williams, G., Al-Tamimi, Y., Bacon, A., Beasley, N., Chew, D., Crank, M., Ilenkovan, N., Macdonald, M., Narice, B., Rominiyi, O., Thompson, A., Varley, I., Drake, T., Harrison, E., Linder, G., Mayes, J., Mcgregor, R., Skipworth, R., Zamvar, V., Hawkin, P., Raymond, T., Ryska, O., Baron, R., Dunne, D., Gahunia, S., Halloran, C., Howes, N., Mckinney, R., Mcnicol, F., Russ, J., Szatmary, P., Tan, J. R., Thomas, A., Whelan, P., Anzak, A., Banerjee, A., Fuwa, O., Hughes, F., Jayasinghe, J. D., Knowles, C., Kocher, H., Leal Silva, I., Ledesma, F. S., Minicozzi, A., Navaratne, L., Rahman, R., Ramamoorthy, R., Sohrabi, C., Thaha, M., Thakur, B., Yip, V., Baumber, R., Parry, J., Evans, S., Jeys, L., Morris, G., Parry, M., Ahmadi, N., Aresu, G., Barrett-Brown, Z. M., Coonar, A. S., Durio Yates, H., Gearon, D., Hogan, J., King, M., Peryt, A., Pradeep, I. S., Adishesh, M., Atherton, R., Baxter, K., Brocklehurst, M., Chaudhury, M., Krishnamohan, N., Mcaleer, J., Owens, G., Parkin, E., Patkar, P., Phang, I., Aladeojebi, A., Ali, M., Barmayehvar, B., Gaunt, A., Gowda, M., Halliday, E., Kitchen, M., Mansour, F., Thomas, M., Zakai, D., Abbassi-Ghadi, N., Assalaarachchi, H., Currie, A., Flavin, M., Frampton, A., Hague, M., Hammer, C., Hopper, J., Horsnell, J., Humphries, S., Kamocka, A., Madhuri, T. K., Preston, S., Singh, P., Stebbing, J., Tailor, A., Walker, D., Aljanadi, F., Jones, M., Mhandu, P., O'Donnell, C., Turkington, R., Al-Ishaq, Z., Bhasin, S., Bodla, A. S., Burahee, A., Crichton, A., Fossett, R., Pigadas, N., Pickford, S., Rahman, E., Snee, D., Yassin, N., Fountain, D., Hasan, M. T., Karabatsou, K., Laurente, R., Pathmanaban, O., Al-Mukhtar, A., Giblin, A., Kelty, C., Lee, M., Lye, G., Newman, T., Sharkey, A., Steele, C., Sureshkumar Shah, N., Whitehall, E., Athwal, R., Baker, A., Jones, L., Konstantinou, C., Ramcharan, S., Vatish, J., Wilkin, R., Ethunandan, M., Sekhon, G. K., Shields, H., Singh, R., Wensley, F., Lawday, S., Lyons, A., Abbott, T., Anwar, S., Ghufoor, K., Chung, E., Hagger, R., Hainsworth, A., Karim, A., Owen, H., Ramwell, A., Williams, K., Baker, C., Davies, A., Gossage, J., Kelly, M., Knight, W., Hall, J., Harris, G., James, G., Kang, C., Lin, D. J., Rajgor, A. D., Royle, T., Scurrah, R., Steel, B., Watson, L. J., Choi, D., Hutchison, R., Jain, A., Luoma, V., Marcus, H., May, R., Menon, A., Pramodana, B., Webber, L., Aneke, I. A., Asaad, P., Brown, B., Collis, J., Duff, S., Moura, F., Wadham, B., Warburton, H., Elmoslemany, T., Jenkinson, M., Millward, C., Zakaria, R., Mccluney, S., Parmar, C., Shah, S., Allison, J., Babar, M. S., Collard, B., Goodrum, S., Lau, K., Scott, R., Thomas, E., Whitmore, H., Balasubramaniam, D., Jayasankar, B., Kapoor, S., Ramachandran, A., Elhamshary, A., Imam, S. M. B., Kapriniotis, K., Kasivisvanathan, V., Lindsay, J., Rakhshani-Moghadam, S., Beech, N., Chand, M., Green, L., Kalavrezos, N., Kiconco, H., Mcewen, R., Schilling, C., Sinha, D., Pereca, J., Chopra, S., Egbeare, D., Thomas, R., Combellack, T., Jones, S. E. F., Kornaszewska, M., Mohammed, M., Sharma, A., Tahhan, G., Valtzoglou, V., Williams, J., Eskander, P., Gash, K., Gourbault, L., Hanna, M., Maccabe, T., Newton, C., Olivier, J., Rozwadowski, S., Teh, E., West, D., Al-Omishy, H., Baig, M., Bates, H., Di Taranto, G., Dickson, K., Dunne, N., Gill, C., Howe, D., Jeevan, D., Khajuria, A., Martin-Ucar, A., Mcevoy, K., Naredla, P., Robertson, S., Sait, M., Sarma, D. R., Shanbhag, S., Shortland, T., Simmonds, S., Skillman, J., Tewari, N., Walton, G., Akhtar, M. A., Brunt, A., Mcintyre, J., Milne, K., Rashid, M. M., Sgro, A., Stewart, K. E., Turnbull, A., Aguilar Gonzalez, M., Talukder, S., Boyle, C., Fernando, D., Gallagher, K., Laird, A., Tham, D., Bath, M., Patki, P., Tanabalan, C., Arif, T., Magee, C., Nambirajan, T., Powell, S., Vinayagam, R., Flindall, I., Hanson, A., Mahendran, V., Green, S., Lim, M., Macdonald, L., Miu, V., Onos, L., Sheridan, K., Young, R., Alam, F., Griffiths, O., Houlden, C., Jones, R., Kolli, V. S., Lala, A. K., Leeson, S., Peevor, R., Seymour, Z., Chen, L., Henderson, E., Loehrer, A., Brown, K., Fleming, D., Heron, C., Hill, C., Kay, H., Leede, E., Mcelhinney, K., Olson, K., Osterberg, E. C., Riley, C., Srikanth, P., Thornhill, M., Blazer, D., Dilalla, G., Hwang, E. S., Lee, W., Lidsky, M., Plichta, J., Rosenberger, L., Scheri, R., Turnage, K., Visgauss, J., Zani, S., Farma, J., Clark, J., Kwon, D., Etchill, E., Gabre-Kidan, A., Jenny, H. E., Kent, A., Ladd, M., Long, C., Malapati, H., Margalit, A., Rapaport, S., Rose, J., Stevens, K., Tsai, L., Vervoort, D., Yesantharao, P., Dehal, A., Klaristenfeld, D., Huynh, K., Brown, L., Mullinax, J., Gusani, N., Hazelton, J., Maines, J., Oh, J. S., Ssentongo, A., Ssentongo, P., Azam, M., Choudhry, A., Marx, W., Fleming, J., Fuson, A., Gigliotti, J., Ovaitt, A., Ying, Y., Abel, M. K., Andaya, V., Bigay, K., Boeck, M. A., Chern, H., Corvera, C., El-Sayed, I., Glencer, A., Ha, P., Hamilton, B. C. S., Heaton, C., Hirose, K., Jablons, D. M., Kirkwood, K., Kornblith, L. Z., Kratz, J. R., Miller, P. N., Nakakura, E., Nunez-Garcia, B., O'Donnell, R., Ozgediz, D., Park, P., Robinson, B., Sarin, A., Sheu, B., Varma, M., Wai, K., Wustrack, R., Xu, M. J., Beswick, D., Goddard, J., Manor, J., Song, J., Fullmer, T., Gaskill, C., Gross, N., Kiong, K., Roland, C. L., Zafar, S. N., Abdallah, M., Abouassi, A., Almasri, M., Kulkarni, G., Marwan, H., Mehdi, M., Aoun, S., Ban, V. S., Batjer, H. H., Caruso, J., Abbott, D., Acher, A., Aiken, T., Barrett, J., Foley, E., Schwartz, P., Hawkins, A., Maiga, A., Laufer, J., Scasso, S., C Glasbey, Jame, Nepogodiev, Dmitri, Ff Simoes, Joana, Omar, Omar, Li, Elizabeth, L Venn, Mary, Abou Chaar, Mohammad, Capizzi, Vita, Chaudhry, Daoud, Desai, Anant, G Edwards, Jonathan, P Evans, Jonathan, Fiore, Marco, Flavio Videria, Jose, J Ford, Samuel, Ganyli, Ian, A Griffiths, Ewen, R Gujjuri, Rohan, G Kolias, Angelo, Ma Kaafarani, Haytham, Minaya-Bravo, Ana, C McKay, Siobhan, M Mohan, Helen, Roberts, Keith, San Miguel-Méndez, Carlo, Pockney, Peter, Shaw, Richard, J Smart, Neil, D Stewart, Grant, Sundar, Sudha, Vidya, Raghavan, A Bhangu, Aneel, Siaw-Acheampong, Kwabena, A Benson, Ruth, Bywater, Edward, E Dawson, Brett, Heritage, Emily, S Jones, Conor, K Kamarajah, Sivesh, Khatri, Chetan, A Khaw, Rachel, M Keatley, Jame, Knight, Andrew, Lawday, Samuel, S Mann, Harvinder, J Marson, Ella, A McLean, Kenneth, C Mills, Emily, Pellino, Gianluca, Picciochi, Maria, H Taylor, Elliott, Tiwari, Abhinav, M Trout, Isobel, Jw Wilkin, Richard, Gallo, Gaetano, Moug, Susan, Pata, Francesco, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Pt Evans, Richard, Townend, Philip, Mckay, Siobhan, Isaac, John, Satoi, Sohei, Edwards, John, S Coonar, Aman, Marchbank, Adrian, J Caruana, Edward, R Layton, Georgia, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelo, J Price, Stephen, M Fountain, Daniel, D Jenkinson, Michael, Hutchinson, Peter, J Marcus, Hani, J Piper, Rory, Lippa, Laura, Servadei, Franco, Esene, Ignatiu, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, K Demetriades, Andrea, Robertson, Faith, Alamri, Alex, G Schache, Andrew, C Winter, Stuart, Ho, Michael, Nankivell, Paul, Rey Biel, Juan, Batstone, Martin, Ganly, Ian, Wilkins, Alex, K Singh, Jagdeep, Thekinkattil, Dinesh, Fotopoulou, Christina, Leung, Elaine, Khan, Tabassum, Chiva, Lui, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thoma, Pareja, Rene, Bristow, Rob, Dowdy, Sean, S Shylasree, T, Kottayasamy Seenivasagam, R, Ng, Joe, Fujiwara, Keiiji, Lamb, Benjamin, Narahari, Krishna, Mcneill, Alan, Colquhoun, Alexandra, Mcgrath, John, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobia, Ef Abbott, Tom, Abukhalaf, Sadi, Adamina, Michel, O Ademuyiwa, Adesoji, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeiers, Marku, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, P Arnaud, Alexi, Magne Augestad, Knut, Ayasra, Fari, Azevedo, José, K Bankhead-Kendall, Brittany, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, A Breen, Kerry, Bretherton, Chri, Lima Buarque, Igor, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moise, F Cunha, Miguel, H Davidson, Giana, M Drake, Thoma, G Edwards, John, Elhadi, Muhammed, Emile, Sameh, Farik, Shebani, Edward Fitzgerald, J, Garmanova, Tatiana, Ghosh, Dhruv, Mendonça Ataíde Gomes, Gustavo, Grecinos, Gustavo, Gründl, Madalegna, Halkias, Constantine, M Harrison, Ewen, Hisham, Intisar, J Hutchinson, Peter, Hwang, Shelley, Isik, Arda, Jonker, Pascal, Keller, Debby, Kruijff, Schelto, Lawani, Ismail, Lederhuber, Han, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, W Löffler, Marku, Aguilera Lorena, Maria, Marta Modolo, Maria, Major, Piotr, Martin, Janet, N Mashbari, Hassan, Mazingi, Denni, Metallidis, Symeon, Moore, Rachel, Moszkowicz, David, S Ng-Kamstra, Joshua, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagro, Ntirenganya, Faustin, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Dione Parreno-Sacdalanm, Marie, Jose Perez Rivera, Carlo, D Pinkney, Thoma, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Ramos-De la Medina, Antonio, C Roslani, April, Rutegård, Martin, José Segura-Sampedro, Juan, Santos, Irène, Sayyed, Raza, Schache, Andrew, A Schnitzbauer, Andrea, O Seyi-Olajide, Justina, Sharma, Neil, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tabiri, Stephen, Tsoulfas, Georgio, H van Ramshorst, Gabrielle, Vimalachandran, Dale, J Warren, Oliver, Wedderburn, Duane, Wright, Naomi, Allemand, C, Boccalatte, L, Figari, M, Lamm, M, Larrañaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Alurralde, C, L Caram, E, Eskinazi, D, P Mendoza, J, Usandivaras, M, Badra, R, Esteban, A, S García, J, M García, P, I Gerchunoff, J, M Lucchini, S, A NIgra, M, Vargas, L, Hovhannisyan, T, Stepanyan, A, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, Mclaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, H Ahn, J, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H, Ballal, M, Gibson, D, Hayne, D, Moss, J, Richards, T, Viswambaram, P, G Vo, U, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, H Lam, Y, S Ong, B, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Jeyarajan, E, Jordan, S, Lim, A, J Nolan, G, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Townend, P, Von Papen, M, Wullschleger, M, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, R Guerra, G, Bolt, J, Buddingh, K, N Dudi-Venkata, N, Jog, S, M Kroon, H, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, Mcgahan, W, Mitchell, D, Morton, A, Pearce, A, Roberts, M, Sheahan, G, Swinson, B, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, W Hii, M, Knowles, B, Mack, J, Read, M, Rowcroft, A, Ward, S, Wright, G, Lanner, M, Königsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Öfner, D, Tsibulak, I, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Öhlberger, L, Presl, J, Wimmer, A, Namazov, I, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, St John, S, Walkes, K, Flamey, N, Pattyn, P, Oosterlinck, W, Van den Eynde, J, Van den Eynde, R, Gatti, A, Nardi, C, Oliva, R, De Cicco, R, Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, F, M Terra, R, Sokolov, M, Kidane, B, Srinathan, S, Boutros, M, Caminsky, N, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S, Dumitra, S, Kouyoumdjian, A, Johnston, B, Russell, C, Demyttenaere, S, Garfinkle, R, Abou-Khalil, J, Nessim, C, Stevenson, J, Heredia, F, Almeciga, A, Fletcher, A, Merchan, A, O Puentes, L, Mendoza Quevedo, J, Bacic, G, Karlovic, D, Krsul, D, Zelic, M, Luksic, I, Mamic, M, Bakmaz, B, Coza, I, Dijan, E, Katusic, Z, Mihanovic, J, Rakvin, I, Frantzeskou, K, Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Yiallourou, A, Martinek, L, Skrovina, M, Szubota, I, Žatecký, J, Javurkova, V, Klat, J, Avlund, T, Christensen, P, L Harbjerg, J, H Iversen, L, W Kjaer, D, Kristensen, Hø, Mekhael, M, L Ebbehøj, A, Krarup, P, Schlesinger, N, Smith, H, Abdelsamed, A, Y Azzam, A, Salem, H, Seleim, A, Abdelmajeed, A, Abdou, M, E Abosamak, N, Al Sayed, M, Ashoush, F, Atta, R, Elazzazy, E, Elhoseiny, M, Elnemr, M, S Elqasabi, M, E Elsayed Hewalla, M, Elsherbini, I, Essam, E, Eweda, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, S Qatora, M, Ragab, M, Sabry, A, Saifeldin, H, Saleh Mesbah Mohamed Elkaffas, M, Samih, A, Samir Abdelaal, A, Shehata, S, Shenit, K, Attia, D, Kamal, N, Osman, N, M Abbas, A, Abd Elazeem, Ha, M Abdelkarem, M, Alaa, S, K Ali, A, Ayman, A, G Azizeldine, M, Elkhayat, H, M Elghazaly, S, A Monib, F, A Nageh, M, M Saad, M, Salah, M, Shahine, M, A Yousof, E, Youssef, A, Eldaly, A, Elfiky, M, Nabil, A, Amira, G, Sallam, I, Sherief, M, Sherif, A, Abdelrahman, A, Aboulkassem, H, Ghaly, G, Hamdy, R, Morsi, A, Sherif, G, Abdeldayem, H, Abdelkader Salama, I, Balabel, M, Fayed, Y, E Sherif, A, Bekele, D, Kauppila, J, Sarjanoja, E, Helminen, O, Huhta, H, H Kauppila, J, Beyrne, C, Jouffret, L, Lugans, L, Marie-Macron, L, Chouillard, E, De Simone, B, Bettoni, J, Dakpé, S, Devauchelle, B, Lavagen, N, Testelin, S, Boucher, S, Breheret, R, Gueutier, A, Kahn, A, KÜn-Darbois, J, Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P, Chebaro, A, Drubay, V, El Amrani, M, Eveno, C, Lecolle, K, Legault, G, Martin, L, Piessen, G, R Pruvot, F, Truant, S, Zerbib, P, Ballouhey, Q, Barrat, B, Laloze, J, Salle, H, Taibi, A, Usseglio, J, Bergeat, D, Merdrignac, A, B Le, Roy, O Perotto, L, Scalabre, A, Aimé, A, Ezanno, A, Malgras, B, Bouche, P, Tzedakis, S, Cotte, E, Glehen, O, Kepenekian, V, Lifante, J, Passot, G, D'Urso, A, Felli, E, Mutter, D, Pessaux, P, Seeliger, B, Bardet, J, Berry, R, Boddaert, G, Bonnet, S, Brian, E, Denet, C, Fuks, D, Gossot, D, Grigoroiu, M, Laforest, A, Levy-Zauberman, Y, Louis-Sylvestre, C, Moumen, A, Pourcher, G, Seguin-Givelet, A, Tribillon, E, Duchalais, E, Espitalier, F, Ferron, C, Malard, O, Bork, U, Distler, M, Fritzmann, J, Kirchberg, J, Praetorius, C, Riediger, C, Weitz, J, Welsch, T, Wimberger, P, Beyer, K, Kamphues, C, Lauscher, J, N Loch, F, Schineis, C, Albertsmeier, M, Angele, M, Kappenberger, A, Niess, H, Schiergens, T, Werner, J, Becker, R, Jonescheit, J, Pergolini, I, Reim, D, Boeker, C, Hakami, I, Mall, J, Liokatis, P, Smolka, W, Nowak, K, Reinhard, T, Hölzle, F, Modabber, A, Winnand, P, Knitschke, M, Kauffmann, P, Wolfer, S, Kleeff, J, Lorenz, K, Michalski, C, Ronellenfitsch, U, Schneider, R, Bertolani, E, Königsrainer, A, W Löffler, M, Quante, M, Steidle, C, Überrück, L, Yurttas, C, S Betz, C, Bewarder, J, Böttcher, A, Burg, S, Busch, C, Gosau, M, Heuer, A, Izbicki, J, O Klatte, T, Koenig, D, Moeckelmann, N, Nitschke, C, Priemel, M, Smeets, R, Speth, U, Thole, S, G Uzunoglu, F, Vollkommer, T, Zeller, N, J Battista, M, Gillen, K, Hasenburg, A, Krajnak, S, Linz, V, Schwab, R, Angelou, K, Haidopoulos, D, Rodolakis, A, Antonakis, P, Bramis, K, Chardalias, L, Contis, I, Dafnios, N, Dellaportas, D, Fragulidis, G, Gklavas, A, Konstadoulakis, M, Memos, N, Papaconstantinou, I, Polydorou, A, Theodosopoulos, T, Vezakis, A, I Antonopoulou, M, K Manatakis, D, Tasis, N, Arkadopoulos, N, Danias, N, Economopoulou, P, Kokoropoulos, P, Larentzakis, A, Michalopoulos, N, Selmani, J, Sidiropoulos, T, Tsaousis, V, Vassiliu, P, Bouchagier, K, Klimopoulos, S, Paspaliari, D, Stylianidis, G, Baxevanidou, K, Bouliaris, K, Chatzikomnitsa, P, Efthimiou, M, Giaglaras, A, Kalfountzos, C, Koukoulis, G, M Ntziovara, A, Petropoulos, K, Soulikia, K, Tsiamalou, I, Zervas, K, Zourntou, S, Baloyiannis, I, Diamantis, A, Gkrinia, E, Hajiioannou, J, Korais, C, Koukoura, O, Perivoliotis, K, Saratziotis, A, Skoulakis, C, Symeonidis, D, Tepetes, K, Tzovaras, G, Zacharoulis, D, Alexoudi, V, Antoniades, K, Astreidis, I, Christidis, P, Deligiannidis, D, Grivas, T, Ioannidis, O, Kalaitsidou, I, Loutzidou, L, Mantevas, A, Michailidou, D, Paraskevopoulos, K, Politis, S, Stavroglou, A, Tatsis, D, Tilaveridis, I, Vahtsevanos, K, Venetis, G, Karaitianos, I, Tsirlis, T, Charalabopoulos, A, Liakakos, T, Mpaili, E, Schizas, D, Spartalis, E, Syllaios, A, Zografos, C, Anthoulakis, C, Christou, C, Papadopoulos, V, Tooulias, A, Tsolakidis, D, Tsoulfas, G, Zouzoulas, D, Athanasakis, E, Chrysos, E, Tsiaoussis, J, Xenaki, S, Xynos, E, Futaba, K, F Ho, M, F Hon, S, Mak, Twc, Ng, Ssm, C Foo, C, Banky, B, Suszták, N, Aremu, M, Canas-Martinez, A, Cullivan, O, Murphy, C, Owens, P, Pickett, L, Akmenkalne, L, Byrne, J, Corrigan, M, Cullinane, C, Daly, A, Fleming, C, Jordan, P, Killeen, S, Lynch, N, Mccarthy, A, Mustafa, H, O'Brien, S, O'Leary, P, Syed, Wa, Vernon, L, Callanan, D, Huang, L, Ionescu, A, Sheahan, P, Balasubramanian, I, Boland, M, Conlon, K, Evoy, D, Fearon, N, Gallagher, T, Geraghty, J, Heneghan, H, Kennedy, N, Maguire, D, Mccartan, D, W McDermott, E, S Prichard, R, Winter, D, Alazawi, D, Barry, C, Boyle, T, Butt, W, M Connolly, E, Donlon, N, Donohue, C, A Fahey, B, Farrell, R, Fitzgerald, C, Kinsella, J, O Larkin, J, Lennon, P, J Maguire, P, Mccormick, P, J Mehigan, B, Mohan, H, Nugent, T, O'Sullivan, H, Ravi, N, V Reynolds, J, Rogers, A, Shokuhi, P, Smith, J, A Smith, L, Timon, C, Bashir, Y, Bass, G, Connelly, T, Creavin, B, Earley, H, A Elliott, J, Gillis, A, Kavanagh, D, Neary, P, O'Riordan, J, S Reynolds, I, Rice, D, Ridgway, P, Umair, M, Whelan, M, Carroll, P, Collins, C, Corless, K, Finnegan, L, Fowler, A, Hogan, A, Kerin, M, Lowery, A, Mcanena, P, Mckevitt, K, Nizami, K, Ryan, É, Samy, A, C Coffey, J, Cunningham, R, Devine, M, Nally, D, Peirce, C, Tormey, S, Hardy, N, O'Malley, S, Ryan, M, Macina, S, M Mariani, N, Opocher, E, Pisani Ceretti, A, Ferrari, F, Odicino, F, Sartori, E, Cotsoglou, C, Granieri, S, Bianco, F, Camillo, A, Colledan, M, Tornese, S, F Zambelli, M, Bissolotti, G, Fusetti, S, Lemma, F, V Marino, M, Mirabella, A, Vaccarella, G, Agostini, C, Alemanno, G, Bartolini, I, Bergamini, C, Bruscino, A, Checcucci, C, De Vincenti, R, Di Bella, A, Fambrini, M, Fortuna, L, Maltinti, G, Muiesan, P, Petraglia, F, Prosperi, P, N Ringressi, M, Risaliti, M, Sorbi, F, Taddei, A, Tucci, R, Bassi, C, Bortolasi, L, Campagnaro, T, Casetti, L, De Pastena, M, Esposito, A, Fontana, M, Guglielmi, A, Landoni, L, Malleo, G, Marchegiani, G, Nobile, S, Paiella, S, Pedrazzani, C, Rattizzato, S, Ruzzenente, A, Salvia, R, Turri, G, Tuveri, M, Bellora, P, D'Aloisio, G, Ferrari, M, Francone, E, Gentilli, S, Nikaj, H, Bianchini, M, Chiarugi, M, Coccolini, F, Di Franco, G, Furbetta, N, Gianardi, D, Guadagni, S, Morelli, L, Palmeri, M, Tartaglia, D, Anania, G, Carcoforo, P, Chiozza, M, De Troia, A, Koleva Radica, M, Portinari, M, G Sibilla, M, Urbani, A, Fabbri, N, V Feo, C, Gennari, S, Parini, S, Righini, E, Ampollini, L, Bellanti, L, Bergonzani, M, Bertoli, G, Bocchialini, G, D'Angelo, G, Lanfranco, D, Musini, L, Poli, T, P Santoro, G, Varazzani, A, Aguzzoli, L, Borgonovo, G, Castro Ruiz, C, Coiro, S, Falco, G, D Mandato, V, Mastrofilippo, V, T Montella, M, Annessi, V, Zizzo, M, Grossi, U, Novello, S, Romano, M, Rossi, S, Zanus, G, Esposito, G, Frongia, F, Pisanu, A, Podda, M, Belluco, C, Lauretta, A, Montori, G, Moras, L, Olivieri, M, Bussu, F, G Carta, A, L Cossu, M, Cottu, P, Fancellu, A, F Feo, C, C Ginesu, G, Giuliani, G, Madonia, M, Perra, T, Piras, A, Porcu, A, Rizzo, D, M Scanu, A, Tedde, A, Tedde, M, Delrio, P, Rega, D, Badalamenti, G, Campisi, G, Cordova, A, Franza, M, Maniaci, G, Rinaldi, G, Toia, F, Calabrò, M, Farnesi, F, G Lunghi, E, Muratore, A, S Pipitone Federico, N, Bàmbina, F, D'Andrea, G, Familiari, P, Picotti, V, De Palma, G, Luglio, G, Pagano, G, P Tropeano, F, Baldari, L, A Beltramini, G, Boni, L, Cassinotti, E, Gianni, A, Pignataro, L, Torretta, S, Abatini, C, Baia, M, Biasoni, D, Bogani, G, Cadenelli, P, Capizzi, V, Cioffi, Spb, Citterio, D, V Comini, L, Cosimelli, M, Fiore, M, Folli, S, Gennaro, M, Giannini, L, Gronchi, A, Guaglio, M, Macchi, A, Martinelli, F, Mazzaferro, V, Mosca, A, Pasquali, S, Piazza, C, Raspagliesi, F, Rolli, L, Salvioni, R, Sarpietro, G, Sarre, C, Sorrentino, L, Agnes, A, Alfieri, S, Belia, F, Biondi, A, Cozza, V, D'Amore, A, D'Ugo, D, De Simone, V, Fagotti, A, Gasparini, G, Gordini, L, Litta, F, P Lombardi, C, Lorenzon, L, A Marra, A, Marzi, F, Moro, A, Parello, A, Perrone, E, Persiani, R, Ratto, C, Rosa, F, Saponaro, G, Scambia, G, Scrima, O, Sganga, G, Tudisco, R, Belli, A, Granata, V, Izzo, F, Palaia, R, Patrone, R, M Carrano, F, M Carvello, M, De Virgilio, A, Di Candido, F, Ferreli, F, Gaino, F, Mercante, G, Rossi, V, Spinelli, A, Spriano, G, M Donati, D, Frisoni, T, Palmerini, E, Aprile, A, Barra, F, Batistotti, P, Ferrero, S, Fregatti, P, Scabini, S, Sparavigna, M, Asti, E, Bernardi, D, Bonavina, L, Lovece, A, Adamoli, L, Ansarin, M, Cenciarelli, S, Chu, F, De Berardinis, R, Fumagalli Romario, U, Mastrilli, F, Pietrobon, G, Tagliabue, M, Badellino, E, Ferrero, A, Massobrio, R, De Manzoni Garberini, A, Federico, P, Maida, P, Marra, E, Marte, G, Petrillo, A, Tammaro, T, Tufo, A, Berselli, M, Borroni, G, Cocozza, E, Conti, L, Desio, M, Livraghi, L, Quintodei, V, Rizzi, A, Zullo, A, Baldi, C, Corbellini, C, M Sampietro, G, Cellerino, P, Baldini, E, Capelli, P, M Isolani, S, Ribolla, M, Bondurri, A, Colombo, F, Ferrario, L, Guerci, C, Maffioli, A, Armao, T, Ballabio, M, Bisagni, P, Gagliano, A, Longhi, M, Madonini, M, Pizzicni, P, M Baietti, A, Biasini, M, Maremonti, P, Neri, F, M Prucher, G, Ricci, S, Ruggiero, F, G Zarabini, A, Barmasse, R, Mochet, S, Usai, A, Incollingo, P, Mancini, S, Marino Cosentino, L, Sagnotta, A, Fruscio, R, Grassi, T, C Nespoli, L, Tamini, N, Anastasi, A, Bartalucci, B, Bellacci, A, Canonico, G, Capezzuoli, L, Di Martino, C, Ipponi, P, Linari, C, Montelatici, M, Nelli, T, Spagni, G, Tirloni, L, Vitali, A, Abate, E, Casati, M, Casiraghi, T, Laface, L, Schiavo, M, Arminio, A, Cotoia, A, Lizzi, V, Vovola, F, Vergari, R, D'Ugo, S, Depalma, N, G Spampinato, M, Bartolucci, P, Brachini, G, Bruzzaniti, P, Chiappini, A, Chiarella, V, Ciccarone, F, M Cicerchia, P, Cirillo, B, De Toma, G, Di Bartolomeo, A, Fiori, E, B Fonsi, G, Franco, G, Frati, A, Giugliano, M, Iannone, I, La Torre, F, Lapolla, P, Leonardo, C, Marruzzo, G, Meneghini, S, Mingoli, A, Ribuffo, D, Salvati, M, Santoro, A, Sapienza, P, K Scafa, A, Simonelli, L, Zambon, M, T Capolupo, G, Carannante, F, Caricato, M, Mascianà, G, Mazzotta, E, Gattolin, A, Migliore, M, Rimonda, R, Sasia, D, Travaglio, E, Cervellera, M, Gori, A, Sartarelli, L, Tonini, V, Giacometti, M, Zonta, S, Chessa, A, Fiorini, A, Norcini, C, Colletti, G, Confalonieri, M, Costanzi, A, Frattaruolo, C, Mari, G, Monteleone, M, Bandiera, A, Bocciolone, L, Bonavina, G, Candiani, M, Candotti, G, De Nardi, P, Gagliardi, F, Medone, M, Mortini, P, Negri, G, Parise, P, Piloni, M, Sileri, P, Vignali, A, Belvedere, A, Bernante, P, Bertoglio, P, Boussedra, S, Brunocilla, E, Cipriani, R, Cisternino, G, De Crescenzo, E, De Iaco, P, Dondi, G, Frio, F, Jovine, E, Mineo Bianchi, F, Neri, J, Parlanti, D, M Perrone, A, P Pezzuto, A, Pignatti, M, Pinto, V, Poggioli, G, Ravaioli, M, Rottoli, M, Schiavina, R, Serenari, M, Serra, M, Solli, P, Taffurelli, M, Tanzanu, M, Tesei, M, Violante, T, Zanotti, S, Borghi, F, Cianflocca, D, Di Maria Grimaldi, S, Donati, D, Gelarda, E, Geretto, P, Giraudo, G, C Giuffrida, M, Marano, A, Palagi, S, Pellegrino, L, Peluso, C, Testa, V, Agresta, F, Prando, D, Zese, M, Aquila, F, Gambacciani, C, Lippa, L, Pieri, F, S Santonocito, O, Armatura, G, Bertelli, G, Frena, A, Marinello, P, Notte, F, Patauner, S, Scotton, G, F Fulginiti, S, Gallo, G, Sammarco, G, Vescio, G, Balercia, P, Catarzi, L, Consorti, G, Di Marzo, F, Fontana, T, Daiko, H, Ishikawa, M, Ishiyama, K, Iwata, S, Kanematsu, K, Kanemitsu, Y, Kato, T, Kawai, A, Kobayashi, E, Kobayashi Kato, M, Moritani, K, Nakatani, F, Oguma, J, Tanase, Y, Uno, M, Al Abdallah, M, Ayasra, F, Ayasra, Y, Qasem, A, J Abu Za'nouneh, F, Fahmawee, T, Hmedat, A, Ibrahim, A, Obeidat, K, Abdel Al, S, Abdel Jalil, R, K Abou Chaar, M, Al-Masri, M, Al-Najjar, H, Alawneh, F, Alsaraireh, O, Elayyan, M, Ghanem, R, Lataifeh, I, Z Alkadeeki, G, S Al Maadany, F, Aldokali, N, Senossi, O, T Subhi, M, Burgan, D, Kamoka, E, I Kilani, A, Salamah, A, Salem, M, Shuwayyah, A, Abdulwahed, E, Alshareea, E, Aribi, N, Aribi, S, Biala, M, Ghamgh, R, Morgom, M, Aldayri, Z, Ellojli, I, Kredan, A, Bradulskis, S, Dainius, E, Kubiliute, E, Kutkevicius, J, Parseliunas, A, Subocius, A, Venskutonis, D, Rasoaherinomenjanahary, F, B Razafindrahita, J, H Samison, L, C Ong, E, H Hamdan, K, R Ibrahim, M, A Tan, J, R Thanapal, M, Amin Sahid, N, Hayati, F, Jayasilan, J, K Sriram, R, Subramaniam, S, Che Jusoh, A, H Hussain, A, S Mohamed Sidek, A, F Mohd Yunus, M, Y Soh, J, Wong, Mpk, D Zakaria, A, Zakaria, Z, Fadzli, A, Q Fathi, N, S Koh, P, T Liew, Y, C Roslani, A, Y Tang, C, Y Teoh, L, J Wong, W, S Yahaya, A, R Alvarez, M, Arrangoiz, R, Cordera, F, A De la Rosa Abaroa, M, Gómez-Pedraza, A, Hernandez, R, Maffuz-Aziz, A, A Posada, J, C Becerra García, F, Alfaro-Goldaracena, A, A Buerba, G, A Castillejos-Molina, R, Chan, C, Dominguez-Rosado, I, Medina-Franco, H, Mercado, Má, Oropeza-Aguilar, M, Peña Gómez Portugal, E, E Posadas-Trujillo, O, Rodriguez-Covarrubias, F, Salgado-Nesme, N, Vilatoba, M, Arkha, Y, Bechri, H, El Ouahabi, A, Y Oudrhiri, M, Derkaoui Hassani, F, El Abbadi, N, Amrani, L, H Belkhadir, Z, Benkabbou, A, Chakib, O, El Ahmadi, B, El Bouazizi, Y, Essangri, H, Ghannam, A, M Majbar, A, Mohsine, R, Souadka, A, Hompes, R, M Meima-van Praag, E, Pronk, Ajm, Sharabiany, S, Grotenhuis, B, Hartveld, L, Reijers, S, Van Houdt, W, Baaij, J, Bolster-van Eenennaam, M, De Graaff, M, Sloothaak, D, Van Duijvendijk, P, Posma-Bouman, L, Derksen, T, Franken, J, Oosterling, S, De Bree, R, Konsten, J, Van Heinsbergen, M, Fidelis, L, T Sholadoye, T, A Tolani, M, Olaogun, J, K Egbuchulem, I, A Lawal, T, Ogundoyin, O, I Olulana, D, Abdur-Rahman, L, Adeyeye, A, Aremu, I, Bello, J, Olasehinde, O, Popoola, A, Massoud, J, Massoud, R, M Sorour, T, Jamal, A, A Kerawala, A, S Memon, A, Nafees Ahmed, R, Rai, L, Ayub, B, Hassan, N, S Martins, R, Ramesh, P, Sayyed, R, Butt, U, Kashif, M, H Khan, W, Qureshi, A, Umar, M, Waris Farooka, M, Wasim, T, Ayubi, A, Rashid, I, H Waqar, S, M Falcon, G, Robles, R, Jocson, R, Teh, C, Major, P, Bobinski, M, Kotarski, J, Rasoul-Pelinska, K, Azevedo, C, Machado, D, Mendes, F, De Sousa, X, Fernandes, U, Ferreira, C, Guidi, G, Leal, C, Marçal, A, Marques, R, Martins, D, Melo, A, Tenreiro, N, Vaz Pereira, R, Vieira, B, I Almeida, J, Correia de Sá, T, Costa, Mjma, Fernandes, V, Ferraz, I, G Gil, C, Lima da Silva, C, Lopes, L, Machado, N, Marialva, J, Nunes Coelho, M, Pedro, J, Pereira, C, Reis, R, Ribeiro, A, Santos, R, Saraiva, P, Silva, R, Tavares, F, Teixeira, M, C Almeida, A, J Amaral, M, Andrade, R, Athayde Nemésio, R, Breda, D, Camacho, C, Canhoto, C, Colino, M, Correia, S, Costa, M, De Barros, J, L De Oliveira López, A, Duque, M, Garrido, S, Guerreiro, P, Guimarães, A, Lázaro, A, Lopes, C, Martins, R, Nogueira, O, Oliveira, A, M Oliveira, J, Rodrigues, M, Ruivo, A, Santos, E, Silva, M, Simões, J, Valente da Costa, A, Almeida, A, Cavaleiro, S, Devezas, V, S Faria, C, Jácome, F, Magalhães Maia, M, Nogueiro, J, Pereira, A, Pereira-Neves, A, Pina-Vaz, T, Santos-Sousa, H, Silveira, H, Vaz, S, Vieira, P, Gomes da Costa, A, Lobo Antunes, I, Pinto, J, Tojal, A, Cardoso, N, Cardoso, P, C Domingues, J, Henriques, P, I Manso, M, Martins Dos Santos, G, Morais, H, Pereira, R, Revez, T, Ribeiro, R, I Ribeiro, V, Soares, A, Sousa, S, Teixeira, J, Amorim, E, H Baptista, V, Cunha MFDias, B, Fazenda, A, P Melo Neves, J, Policarpo, F, I Sampaio da Nóvoa Gomes Miguel, I, Veiga, D, K Andrade, A, P Bandovas, J, Borges, N, Branquinho, A, Chumbinho, B, Correia, J, Fidalgo, H, Figueiredo de Barros, I, Frade, S, Gomes, J, Maciel, J, Pina, S, Rodrigues, A, Silva, N, Silveira Nunes, I, Sousa, R, Ascensão, J, Azevedo, P, Costeira, B, Cunha, C, Garrido, R, Gomes, H, Lourenço, I, Mendinhos, G, Miranda, P, Nobre Pinto, A, Peralta Ferreira, M, Ribeiro, J, Rio Rodrigues, L, Sousa Fernandes, M, Azevedo, J, Galvão, D, C Soares, A, Vieira, A, Patrício, B, Santos, Pmdd, C Vieira Paiva Lopes, A, Cunha, R, Faustino, A, Freitas, A, R Martins ABMendes, J, Parreira, R, Rosa, J, Teves, M, Abreu da Silva, A, Claro, M, Costa Santos, D, C Deus, A, V Grilo, J, Borges, F, Corte Real, J, Henriques, S, J Lima, M, Matos Costa, P, Brito da Silva, F, Caiado, A, Fonseca, F, Ângelo, M, M Baiao, J, Martins Jordão, D, Vieira Caroço, T, Messias, J, Millan, A, Salgado, I, Santos, P, Baía, C, Canotilho, R, M Correia, A, P Ferreira Pinto, A, Peyroteo, M, F Videira, J, Escobar, P, Maldonado Santiago, M, Kassir, R, Sauvat, F, Bezede, C, Chitul, A, Ciofic, E, Cristian, D, Grama, F, Pirtea, L, Secosan, C, Bonci, E, Gata, V, Titu, S, Ginghina, O, Iordache, N, V Iosifescu, R, Garmanova, T, Kazachenko, E, Markaryan, D, Rodimov, S, Tsarkov, P, Tulina, I, Litvina, Y, Provozina, A, Agapov, M, Galliamov, E, Kakotkin, V, Kubyshkin, V, Kamalov, А, Alshahrani, M, Alsharif, F, Eskander, M, Al Raddadi, R, Majrashi, S, Mashat, A, Akeel, N, Alharthi, M, Aljiffry, M, Basendowah, M, Farsi, A, Ghunaim, M, Khoja, A, Maghrabi, A, Malibary, N, Nassif, M, Nawawi, A, Saleem, A, Samkari, A, Trabulsi, N, Al Awwad, S, Alghamdi, M, Alnumani, T, Nasser, M, Said Bayazeed, A, Alhefdhi, A, Almalik, O, Alomair, A, Alotaibi, N, Alresaini, F, Alsalamah, R, Alsobhi, S, Mahasin, Z, Othman, E, Velagapudi, S, Ghedan, S, Alharthi, R, Awad, S, I Sharara, M, Abdelrahman, S, Althobaiti, W, Al Habes, H, Alamri, A, Alkarak, S, Alqannas, M, Alyami, M, Alzamanan, M, Cortés Guiral, D, Elawad, A, Alaamer, O, Alriyees, L, Alselaim, N, Abdulkareem, A, Ajlan, A, Akkour, K, Al-Habib, A, Al-Khayal, K, Alatar, A, Alburakan, A, Alhalal, H, Alhassan, B, Alhassan, N, Alobeed, O, Alsaif, A, Alsaif, F, Alshammari, S, Alshaygy, I, Barry, M, Bin Nasser, A, Bin Traiki, T, Bokhari, A, Elwatidy, S, Helmi, H, Madkhali, A, Nouh, T, D Rabah, P, Zubaidi, A, Paunovic, I, Slijepcevic, N, Aleksic, L, Antic, A, Barisic, G, Ceranic, M, Galun, D, Grubac, Ž, Jelenkovic, J, Kecmanovic, D, Kmezic, S, Knezevic, D, Krivokapic, Z, Latincic, S, Markovic, V, Matic, S, Miladinov, M, Pavlov, M, Pejovic, I, Radenkovic, D, Tadic, B, Vasljevic, J, Velickovic, D, Zivanovic, M, Perovic, M, Srbinovic, L, Andrijasevic, S, Bozanovic, T, Cerovic Popovic, R, Dokic, M, Janjic, T, Jeremic, K, Kadija, S, Ladjevic Likic, I, Mirkovic, L, Pantovic, S, Pilic, I, Radojevic, M, Stefanovic, A, Vidakovic, S, Vilendecic, Z, Antic, S, Dunderovic, D, Jelovac, D, Jezdic, Z, Konstantinovic, V, Kotlar, B, Kuzmanovic, C, Lazic, M, Petrovic, M, Popovic, F, Pucar, A, Romic, M, Sumrak, S, Vujanac, V, Bascarevic, V, Bogdanovic, I, Grujicic, D, Ilic, R, Milicevic, M, Milisavljevic, F, Miljkovic, A, Paunovic, A, Scepanovic, V, Stanimirovic, A, Todorovic, M, Jotic, A, Milovanovic, J, Trivic, A, Bumbasirevic, U, Dzamic, Z, Kajmakovic, B, Prijovic, N, Zivkovic, M, Buta, M, Cvetkovic, A, Djurisic, I, Gacic, S, Goran, M, Inic, Z, Jeftic, N, Jevric, M, Jokic, V, Markovic, I, Milanovic, M, Nikolic, S, Pejnovic, L, Savkovic, N, Spurnic, I, Stevic, D, Stojiljkovic, D, Vucic, N, Zegarac, M, Karamarkovic, A, Kenic, M, Kovacevic, B, Krdzic, I, Milutinovic, V, W Chan, C, Lieske, B, Gális, B, Šimko, K, Almgla, N, Bernon, M, Boutall, A, Cairncross, L, Herman, A, Hilton, T, Jonas, E, Kloppers, C, Malherbe, F, Mugla, W, Nel, D, Rayamajhi, S, Van Wyngaard, T, Vogel, J, M Castaño-Leon, A, Delgado Fernandez, J, Eiriz Fernandez, C, Espino Segura-Illa, M, Esteban Sinovas, O, Garcia Perez, D, Gomez, P, Jimenez-Roldan, L, Lagares, A, Moreno-Gomez, L, Paredes, I, Pérez Núñez, A, Sánchez Aniceto, G, Santas, M, Fernández Rodríguez, P, Paniagua García Señorans, M, Sanchez-Santos, R, Vigorita, V, Acrich, E, Baena Sanfeliu, E, Barrios, O, Golda, T, Santanach, C, Serrano-Navidad, M, Sorribas Grifell, M, V Vives, R, Escolà, D, Jiménez, A, Cayetano Paniagua, L, Gómez Fernández, L, Artigues, E, C Bernal-Sprekelsen, J, C Catalá Bauset, J, Collera, P, Diaz De, L, Gobbo, R, Farre Font, R, Flores Clotet, R, J Gómez Díaz, C, Guàrdia, N, A Guariglia, C, Osorio, A, Sanchez Jimenez, R, Sanchon, L, Soto Montesinos, C, Albi Martin, B, E García Villayzán, J, Alonso-Lamberti, L, Assaf, M, Baeza Pintado, N, Carabias, A, García-Quijada, J, A Huertas Fernandez, M, Jimenez Miramón, J, Jimenez, V, M Jover, J, A Landeo AgÜero, S, Leon, R, B Martín Salamanca, M, Pérez Simón, V, Ponce, S, L Rodriguez, J, Salazar, A, Valle Rubio, A, Aguado, H, Aldecoa Ansorregui, I, Bravo Infante, R, B De Lacy, F, Di Somma, A, Díaz-Feijoo, B, Enseñat Nora, J, Fabregas, N, Ferrés, A, Gil Ibañez, B, J Gonzalez Sanchez, J, Gracia, I, A Hoyos Castro, J, M Lacy, A, Langdon, C, Momblán, D, Morales, X, Oleaga, L, Otero, A, Pedrosa, L, Poblete Carrizo, J, A Reyes Figueroa, L, Roldan Ramos, P, Rumia-Arboix, J, I Tercero-Uribe, A, E Topczewski, T, Torales, J, Torne, A, Torné, R, Turrado-Rodriguez, V, Valero, R, Valverde, S, Anula, R, Cano-Valderrama, O, Del Campo Martín, M, Díez-Valladares, L, Domínguez, I, Dziakova, J, García Alonso, M, García Romero, E, Gómez Latorre, L, M Muguerza, J, J Pizarro, M, Saez Carlin, P, Sánchez Del Pueblo, C, Sánchez-Pernaute, A, Sanz Ortega, G, Sanz-Lopez, R, Torres, A, Garcés-Albir, M, Lopez, F, Martín-Arévalo, J, Moro-Valdezate, D, Pla-Marti, V, Beltrán de Heredia, J, De Andrés Asenjo, B, Gómez Sanz, T, Jezieniecki, C, Nuñez Del Barrio, H, J Ortiz de Solórzano Aurusa, F, Romero de Diego, A, Ruiz Soriano, M, Trujillo Díaz, J, Vazquez Fernandez, A, Lora-Cumplido, P, V Sosa, M, Gonzalez-Gonzalez, E, M Minaya Bravo, A, Alonso de la Fuente, N, Cazador Labat, M, Cecchini, L, A Espinosa, C, Jimenez Toscano, M, López Campillo, A, Mancebo, G, Martorell, P, Munarriz, M, J Grau-Talens, E, Martin-Perez, B, A Benavides Buleje, J, Carrasco Prats, M, V Fernández, P, Fernández-López, A, García Escudero, D, J García Porcel, V, Garcia Soria, V, Giménez Francés, C, M González Valverde, F, Gurrea, E, López-Morales, P, Marco Garrido, A, A Martínez Alonso, J, Medina, E, M Muñoz Camarena, J, A Parra Baños, P, Peña Ros, E, Ramirez Faraco, M, Ruiz-Marín, M, Sanchez Rodriguez, C, Valero Soriano, M, Estaire Gómez, M, Fernández Camuñas, Á, P Garcia Santos, E, Jimenez Higuera, E, Martínez-Pinedo, C, Muñoz-Atienza, V, Padilla-Valverde, D, Picón Rodríguez, R, J Redondo Calvo, F, Sánchez-García, S, Sanchez-Pelaez, D, C Colombari, R, Del Valle, E, Fernández, M, Lozano Lominchar, P, Martín, L, Rey Valcarcel, C, A Steiner, M, Tudela, M, Zorrilla Ortúzar, J, Alcaide Matas, F, M García Pérez, J, Troncoso Pereira, P, Mora-Guzmán, I, Abellán, M, Achalandabaso Boira, M, Jorba, R, Memba Ikuga, R, Olona, C, Sales Mallafré, R, Cavallé Busquets, P, Gavalda Pellice, Mgp, Salinas Peña, J, J Aragon Achig, E, Barbier, L, Caja Vivancos, P, Gainza, A, J García Gutierrez, J, Mallabiabarrena Ormaechea, G, Marín, H, Martin Playa, P, Melchor Corcóstegui, I, Prieto Calvo, M, Rodriguez Fraga, A, Villalabeitia Ateca, I, De Andres Olabarria, U, Durán Ballesteros, M, J Fernández Pablos, F, J Ibáãez-Aguirre, F, Sanz Larrainzar, A, Ugarte-Sierra, B, De la Hoz Rodríguez, Á, Di Martino, M, García Septiem, J, Martin-Perez, E, L Muñoz de Nova, J, Calvo Espino, P, Guillamot Ruano, P, Colao García, L, Díaz Pérez, D, Esteban Agustí, E, Galindo Jara, P, Gutierrez Samaniego, M, A Hernandez Bartolome, M, Serrano González, J, Alonso Poza, A, Diéguez, B, García-Conde, M, Hernández-García, M, Losada, M, M Chiesa-Estomba, C, González García, Já, Larruscain, E, A Sistiaga-Suárez, J, Alvarez, E, Chavarrias, N, Frías, L, García Pineda, V, Gegúndez Simón, A, Gortázar, S, Gracia, M, Guevara, J, Hernández Gutierrez, A, Loayza, A, T María Dolores, D, Martí, C, Melendez, M, Moreno-Palacios, E, Perez, Y, I Prieto Nieto, M, Ramos-Martín, P, Rubio-Perez, I, Saavedra, J, I Sanchez-Mendez, J, Siegrist Ridruejo, J, Urbieta, A, Zapardiel, I, Cantalejo Diaz, M, De Miguel Ardevines, Mdc, Duque-Mallén, V, Gascon Ferrer, I, T González-Nicolás Trébol, M, Gracia-Roche, C, Herrero Lopez, M, M Jariod Ferrer, U, Lanzon, A, Martinez German, A, Matute, M, Redondo, C, Sánchez Fuentes, N, Sánchez-Rubio, M, S Santero-Ramirez, M, Saudí, S, V Simón Sanz, M, Uson-Bouthelier, T, Blazquez Martin, A, Diez Alonso, M, García Rico, E, Garcia-Loarte Gomez, E, Garcia-Moreno Nisa, F, Gutierrez Calvo, A, Hernandez, P, Lasa, I, Mendoza-Moreno, F, Morales Palacios, N, Ovejero Merino, E, Vera Mansilla, C, Acebes García, F, Bailón, M, D Bueno Cañones, A, Choolani Bhojwani, E, Marcos-Santos, P, Miguel, T, Pacheco Sánchez, D, Pérez-Saborido, B, Sanchez Gonzalez, J, J Tejero-Pintor, F, Alconchel, F, Conesa, A, Gil Martínez, J, I Gutiérrez Fernández, A, Lopez Abad, A, Nicolás-López, T, Ramirez Romero, P, J Roca Calvo, M, Rodrigues, K, J Ruiz Manzanera, J, I Soriano, A, Cano, A, Capitan-Morales, L, Cintas Catena, J, Gomez-Rosado, J, Oliva Mompean, F, A Pérez Sánchez, M, D Río Lafuente, F, Torres Arcos, C, Valdes-Hernandez, J, Cholewa, H, Domingo, S, Frasson, M, Lago, V, Marina Martin, T, Martínez Chicote, C, Sancho-Muriel, J, Landaluce-Olavarria, A, Lecumberri, D, Abad Gurumeta, A, Abad-Motos, A, Martínez-Hurtado, E, Ripollés-Melchor, J, Ruiz Escobar, A, Cuadrado-García, A, Garcia-Sancho Tellez, L, Heras Aznar, J, Maté, P, Ortega Vázquez, I, L Picardo, A, A Rojo López, J, Sanchez Cabezudo Noguera, F, Serralta de Colsa, D, Anchuelo Latorre, J, Cagigas Fernandez, C, Caiña Ruiz, R, Gomez Ruiz, M, Hernanz, F, Jimeno Fraile, J, Martínez-Pérez, P, Poch, C, Santarrufina Martinez, S, Valbuena Jabares, V, Moliner-Sánchez, C, Pingarron-Martin, L, Rey-Biel, J, Ruiz Martin, I, L Blas Laina, J, Cros, B, Escartin, J, Garcia Egea, J, Nogués, A, Talal El-Abur, I, Yánez, C, P Cagigal Ortega, E, Cervera, I, Díaz Peña, P, Elena, Gdcr, Enjuto, D, Fernández Bernabé, P, Garcés García, R, Gonzalez, J, Hernández, I, Herrera-Merino, N, Marqueta De Salas, M, Martinez Pascual, P, Perez Gonzalez, M, Ramos Bonilla, A, Rodríguez Gómez, L, Bescós, C, Blanco-Colino, R, Brana, I, Caimari, B, De Pablo García-Cuenca, A, Duran-Valles, F, Espin-Basany, E, Giralt Lóez de Sagredo, J, Pamias, J, Pellino, G, Prat, N, Pujol Pina, R, Saez Barba, M, Arulanantham, A, Bandara, Gbk, Jayarajah, U, Ravindrakumar, S, S Rodrigo, V, Srishankar, S, A Ali Karar, A, Elbe, P, K Lindqvist, E, Taflin, H, Älgå, A, Heinius, G, Nordberg, M, Pieniowski, E, Gkekas, I, Löfgren, N, Rutegård, M, Sund, M, Arigoni, M, Bernasconi, M, Christoforidis, D, Di Giuseppe, M, La Regina, D, Mongelli, F, Chevallay, M, Dwidar, O, Gialamas, E, Sauvain, M, Klenke, F, Kollàr, A, Kurze, C, Adamina, M, Bächler, T, S Crugnale, A, Giardini, M, Guglielmetti, L, Peros, G, Solimene, F, Aghayeva, A, Hamzaoglu, I, Sahin, I, Akaydin, E, Aliyeva, Z, Aytac, E, Baca, B, Dülgeroğlu, O, Ozben, V, B Ozmen, B, Uras, C, E Arikan, A, A Bilgin, I, Bozkirli, B, O Ceyhan, G, Kara, H, Karahasanoglu, T, Celik, H, M Meydanli, M, Akilli, H, Ayhan, A, Kuscu, E, A Onan, M, Akgor, U, A Dincer, H, Erol, T, Gultekin, M, Orhan, N, Ozgul, N, C Salman, M, Soyak, B, Alhamed, A, Ergün, S, F OZcelik, M, N Sanli, A, S Uludag, S, Velidedeoglu, M, K Zengin, A, A Bozkurt, M, Kara, Y, Kocatas, A, Cimenoglu, B, Demirhan, R, Saracoglu, K, F Azamat, I, Balik, E, Bugra, D, Giray, B, B Kulle, C, Taskiran, C, Vatansever, D, Gözal, K, A GÜler, S, Köken, H, C Tatar, O, Z Utkan, N, Yildirim, A, Yüksel, E, Akin, E, Altintoprak, F, Bayhan, Z, Cakmak, G, Çapoglu, R, Çelebi, F, Demir, H, Dikicier, E, Firat, N, Gönüllü, E, B Kamburoglu, M, Kocer, B, F KÜçÜk, I, Mantoglu, B, Çolak, E, O Kucuk, G, S Uyanik, M, Göksoy, B, Bozkurt, E, Citgez, B, Mihmanli, M, Tanal, M, Yetkin, G, Akalin, M, Arican, C, K Avci, E, Aydin, C, Demirli Atici, S, Emiroglu, M, Kaya, T, Kebabçi, E, Kilinc, G, Kirmizi, Y, Ogucu, H, Salimoglu, S, Sert, I, Tugmen, C, Tuncer, K, Uslu, G, Yesilyurt, D, Karaman, E, Kolusari, A, Yildiz, A, Benson, O, Lule, H, Agilinko, J, Ahmeidat, A, Barabasz, M, Bekheit, M, K Cheung, L, Colloc, T, Cymes, W, Elhusseini, M, Gradinariu, G, Hannah, A, S Kamera, B, Mignot, G, Shaikh, S, Sharma, P, Abu-Nayla, I, Agrawal, A, Al-Mohammad, A, Ali, S, Ashcroft, J, Azizi, A, Baker, O, Balakrishnan, A, Byrne, M, Colquhoun, A, Cotter, A, Coughlin, P, J Davies, R, Durrani, A, Elshaer, M, Fordington, S, Forouhi, P, Georgiades, F, Grimes, H, Habeeb, A, Hudson, V, Hutchinson, P, Irune, E, Jah, A, Z Khan, D, Kolias, A, Kyriacou, H, Lamb, B, Liau, S, Luke, L, Mahmoud, R, Mannion, R, Masterson, L, G Mitrofan, C, Mohan, M, Morris, A, Murphy, S, O'Neill, R, Price, S, Pushpa-Rajah, J, Raby-Smith, W, Ramzi, J, Rooney, S, Santarius, T, Singh, A, D Stewart, G, S Tan, X, Townson, A, Tweedle, E, Walker, C, Waseem, S, Yordanov, S, Jones, T, Kattakayam, A, Loh, C, Lunevicius, R, Pringle, S, Schache, A, Shaw, R, Sheel, A, Rossborough, C, Angelou, D, Choynowski, M, Mcaree, B, Mccanny, A, Neely, D, Tutoveanu, G, Ahad, S, De La Cruz Monroy, Mfi, Mosley, F, Oktseloglou, V, Alanbuki, A, Patel, M, Shabana, A, Perera, E, Raveendran, D, Ravi-Shankar, K, Thiruchelvam, J, Arrowsmith, L, Campbell, W, Grove, T, Kontovounisios, C, Warren, O, Rolland, P, Aggarwal, A, Brown, S, Jelley, C, Neal, N, Clifford, R, Eardley, N, Krishnan, E, Manu, N, Martin, E, Roy Mahapatra, S, L Serevina, O, Smith, C, Vimalachandran, D, Bordenave, M, Houston, R, Putnam, G, Robson, A, Tustin, H, Emslie, K, L Labib, P, Marchbank, A, Miller, D, Minto, G, Natale, J, Nwinee, H, Panahi, P, Rogers, L, Abubakar, A, M Akhter Rahman, M, Ko, Kyk, O'Brien, H, Sasapu, K, Woodun, H, Inglis, R, J Ng, H, De Gea Rico, A, Ghazali, N, Lambert, J, Markose, G, Math, S, Sarantitis, I, Shrestha, D, Sultana, A, Taggarsi, M, Timbrell, S, P Vaz, O, Vitone, L, Day, A, Dent, H, Fahim, M, Waheed, S, Hunt, A, Laskar, N, Gupta, A, Steinke, J, Thrumurthy, S, Massie, E, Mcgivern, K, Rutherford, D, Wilson, M, Hardie, J, Kazzaz, S, Handa, S, Kaushal, M, Kler, A, Patel, P, Redfern, J, Tezas, S, Aawsaj, Y, Amonkar, S, Blackwell, L, Blake, D, Carter, J, Emerson, H, Fisher, A, Katory, M, Korompelis, P, Mccormick, W, Mustafa, A, Pearce, L, Ratnavelu, N, Reehal, R, Kretzmer, L, Lalou, L, Manku, B, Parwaiz, I, Stafford, J, Abdelkarim, M, Asqalan, A, Gala, T, Ibrahim, S, Maw, A, Mithany, R, Morgan, R, Sundaram Venkatesan, G, Ang, K, J Caruana, E, F Chowdhry, M, Mohammad, A, Nakas, A, Rathinam, S, Boal, M, Brown, O, Dwerryhouse, S, Higgs, S, Vallance, A, Boyd, E, Irvine, V, Kirk, A, Bakolas, G, Boulton, A, Chandock, A, Khan, T, Kumar, M, Agoston, P, Bille, A, Challacombe, B, Fraser, S, Harrison-Phipps, K, King, J, Mehra, G, Mills, L, Najdy, M, Nath, R, Okiror, L, Pilling, J, Rizzo, V, Routledge, T, Sayasneh, A, Stroman, L, Wali, A, Fehervari, M, Fotopoulou, C, Habib, N, Hamrang-Yousefi, S, Jawad, Z, Jiao, L, Pai, M, Ploski, J, Rajagopal, P, Saso, S, Sodergren, M, Spalding, D, Laws, S, Hardie, C, Mcnaught, C, Alam, R, Budacan, A, Cahill, J, Kalkat, M, Karandikar, S, Kenyon, L, Naumann, D, Patel, A, Ayorinde, J, Chase, T, Cuming, T, Ghanbari, A, Humphreys, L, Tayeh, S, Aboelkassem Ibrahim, A, Bichoo, R, Cao, H, Chai, Akw, Choudhury, J, Evans, C, Fitzjohn, H, Ikram, H, Langstroth, M, Loubani, M, Mcmillan, A, Nazir, S, Qadri, Ssa, Robinson, A, Ross, E, Sehgal, T, Wilkins, A, Dixon, J, Dunning, J, Freystaetter, K, Jha, M, Lester, S, Madhavan, A, V Thulasiraman, S, Viswanath, Y, Curl-Roper, T, Delimpalta, C, Liao, Ccl, Velchuru, V, Westwood, E, Belcher, E, Bond-Smith, G, Chidambaram, S, Di Chiara, F, Fasanmade, K, Fraser, L, Fu, H, Ganau, M, Gore, S, Graystone, J, Jeyaretna, D, Khatkar, H, Lami, M, Maher, M, Mastoridis, S, Mihai, R, Piper, R, Prabhu, S, Risk, Obf, Selbong, U, Shah, K, Smillie, R, Soleymani Majd, H, Sravanam, S, Stavroulias, D, D Tebala, G, Vatish, M, Verberne, C, Wallwork, K, Winter, S, I Bhatti, M, Boyd-Carson, H, Elsey, E, Gemmill, E, Herrod, P, Jibreel, M, Lenzi, E, Saafan, T, Sapre, D, Sian, T, Watson, N, Athanasiou, A, Bourke, G, Bradshaw, L, Brunelli, A, Burke, J, Coe, P, Costigan, F, Elkadi, H, Ho, M, Johnstone, J, Kanatas, A, Kantola, V, Kaufmann, A, Laios, A, Lam, S, Macinnes, E, Munot, S, Nahm, C, Otify, M, Pompili, C, Smith, I, Theophilou, G, Toogood, G, Wade, R, Ward, D, West, C, Annamalai, S, Ashmore, C, Boddy, A, Hossain, T, Kourdouli, A, Gvaramadze, A, Jibril, A, Prusty, L, Thekkinkattil, D, Harky, A, Shackcloth, M, Askari, A, Cirocchi, N, Kudchadkar, S, Patel, K, Sagar, J, Shaw, S, Talwar, R, Abdalla, M, Edmondson, R, Ismail, O, Jones, D, Newton, K, Stylianides, N, Aderombi, A, Andaleeb, U, Bajomo, O, Beatson, K, Garrett, W, Mehmood, M, Ng, V, Al-Habsi, R, S Divya, G, Keeler, B, Al-Sarireh, B, Egan, R, Harries, R, Henry, A, Kittur, M, Li, Z, Parkins, K, Soliman, F, Spencer, N, Thompson, D, Burgess, C, Gemmell, C, Grieco, C, Hollyman, M, Hunt, L, Morrison, J, Ojha, S, Ryan, N, Abbadessa, F, Barnard, S, Dawe, N, Hammond, J, F Mahmoud, Ali, Mcpherson, I, Mellor, C, Moir, J, Pandanaboyana, S, Powell, J, Rai, B, Roy, C, Sachdeva, A, Saleh, C, Tingle, S, Williams, T, Manickavasagam, J, Mcdonald, C, Mcgrath, N, Mcsorley, N, Ragupathy, K, Ramsay, L, Solth, A, Kakisi, O, Seebah, K, Shaikh, I, Sreedharan, L, Youssef, M, Shah, J, Ameerally, P, Mclarty, N, Mills, S, Shenfine, A, Sahnan, K, Abu, J, Addae-Boateng, E, Bratt, D, Brock, L, Burnside, N, Cadwell-Sneath, S, Gajjar, K, Gan, C, Grundy, C, Hallam, K, Hassell, K, Hawari, M, Joshi, A, Khout, H, Konstantinidi, K, Lee, Rxn, Nunns, D, Schiemer, R, Walton, T, Weaver, H, Whisker, L, Williamson, K, Mcveigh, J, Myatt, R, A Williams, M, Kaur, R, Leung, E, Sundar, S, Michel, M, Patil, S, Ravindran, S, Sarveswaran, J, Scott, L, Edmond, M, King, E, Almond, M, Bhangu, A, Breik, O, D Cato, L, Desai, A, Ford, S, Griffiths, E, Idle, M, Kamal, M, Kisiel, A, Kulkarni, R, Mak, Jkc, Martin, T, Nankivell, P, Parente, A, Parmar, S, M Pathanki, A, Phelan, L, Praveen, P, Saeed, S, Sharma, N, Singh, J, Tirotta, F, Vijayan, D, Geddes, A, Mccaul, J, Mcmahon, J, H Khan, A, Khan, F, Mansuri, A, Mukherjee, S, Sarigul, M, Singh, S, L Tan, K, Woodham, A, Adiamah, A, Brewer, H, Chowdhury, A, Evans, J, Humes, D, Jackman, J, Koh, A, Lewis-Lloyd, C, Oyende, O, Reilly, J, Worku, D, Cool, P, Cribb, G, Shepherd, K, Bisset, C, Moug, S, Elson, N, Faulkner, G, Saleh, P, Underwood, C, Brixton, G, Findlay, L, Klatte, T, Majkowska, A, Manson, J, Potter, R, Bhalla, A, Chia, Z, Daliya, P, Goyal, A, Grimley, E, Hamad, A, Kumar, A, L Malcolm, F, Theophilidou, E, Bowden, J, Campain, N, Daniels, I, Fowler, G, John, J, Massey, L, Mcdermott, F, Mcgrath, J, Mclennan, A, Ng, M, Pascoe, J, Rajaretnam, N, Bulathsinhala, S, Davidson, B, Fusai, G, Hidalgo Salinas, C, Machairas, N, Pissanou, T, M Pollok, J, A Raptis, D, Soggiu, F, Tzerbinis, H, E Xyda, S, Beamish, A, Davies, E, Foulkes, R, Magowan, D, Nassa, H, Ooi, R, Price, C, Smith, L, Solari, F, Tang, A, Williams, G, Al-Tamimi, Y, Bacon, A, Beasley, N, Chew, D, Crank, M, Ilenkovan, N, Macdonald, M, Narice, B, Rominiyi, O, Thompson, A, Varley, I, Drake, T, Harrison, E, Linder, G, Mayes, J, Mcgregor, R, Skipworth, R, Zamvar, V, Hawkin, P, Raymond, T, Ryska, O, Baron, R, Dunne, D, Gahunia, S, Halloran, C, Howes, N, Mckinney, R, Mcnicol, F, Russ, J, Szatmary, P, R Tan, J, Thomas, A, Whelan, P, Anzak, A, Banerjee, A, Fuwa, O, Hughes, F, D Jayasinghe, J, Knowles, C, Kocher, H, Leal Silva, I, S Ledesma, F, Minicozzi, A, Navaratne, L, Rahman, R, Ramamoorthy, R, Sohrabi, C, Thaha, M, Thakur, B, Venn, M, Yip, V, Baumber, R, Parry, J, Evans, S, Jeys, L, Morris, G, Parry, M, Ahmadi, N, Aresu, G, M Barrett-Brown, Z, S Coonar, A, Durio Yates, H, Gearon, D, Hogan, J, King, M, Peryt, A, S Pradeep, I, Adishesh, M, Atherton, R, Baxter, K, Brocklehurst, M, Chaudhury, M, Krishnamohan, N, Mcaleer, J, Owens, G, Parkin, E, Patkar, P, Phang, I, Aladeojebi, A, Ali, M, Barmayehvar, B, Gaunt, A, Gowda, M, Halliday, E, Kitchen, M, Mansour, F, Thomas, M, Zakai, D, Abbassi-Ghadi, N, Assalaarachchi, H, Currie, A, Flavin, M, Frampton, A, Hague, M, Hammer, C, Hopper, J, Horsnell, J, Humphries, S, Kamocka, A, K Madhuri, T, Preston, S, Singh, P, Stebbing, J, Tailor, A, Walker, D, Aljanadi, F, Jones, M, Mhandu, P, O'Donnell, C, Turkington, R, Al-Ishaq, Z, Bhasin, S, S Bodla, A, Burahee, A, Crichton, A, Fossett, R, Pigadas, N, Pickford, S, Rahman, E, Snee, D, Vidya, R, Yassin, N, Fountain, D, T Hasan, M, Karabatsou, K, Laurente, R, Pathmanaban, O, Al-Mukhtar, A, Edwards, J, Giblin, A, Kelty, C, Lee, M, Lye, G, Newman, T, Sharkey, A, Steele, C, Sureshkumar Shah, N, Whitehall, E, Athwal, R, Baker, A, Jones, L, Konstantinou, C, Ramcharan, S, Vatish, J, Wilkin, R, Ethunandan, M, K Sekhon, G, Shields, H, Singh, R, Wensley, F, Lawday, S, Lyons, A, Abbott, T, Anwar, S, Ghufoor, K, Chung, E, Hagger, R, Hainsworth, A, Karim, A, Owen, H, Ramwell, A, Williams, K, Baker, C, Davies, A, Gossage, J, Kelly, M, Knight, W, Hall, J, Harris, G, James, G, Kang, C, J Lin, D, D Rajgor, A, Royle, T, Scurrah, R, Steel, B, J Watson, L, Choi, D, Hutchison, R, Jain, A, Luoma, V, Marcus, H, May, R, Menon, A, Pramodana, B, Webber, L, A Aneke, I, Asaad, P, Brown, B, Collis, J, Duff, S, Khan, A, Moura, F, Wadham, B, Warburton, H, Elmoslemany, T, Jenkinson, M, Millward, C, Zakaria, R, Mccluney, S, Parmar, C, Shah, S, Allison, J, S Babar, M, Collard, B, Goodrum, S, Lau, K, Scott, R, Thomas, E, Whitmore, H, Balasubramaniam, D, Jayasankar, B, Kapoor, S, Ramachandran, A, Elhamshary, A, Imam, Smb, Kapriniotis, K, Kasivisvanathan, V, Lindsay, J, Rakhshani-Moghadam, S, Beech, N, Chand, M, Green, L, Kalavrezos, N, Kiconco, H, Mcewen, R, Schilling, C, Sinha, D, Pereca, J, Chopra, S, Egbeare, D, Thomas, R, Combellack, T, Jones, Sef, Kornaszewska, M, Mohammed, M, Sharma, A, Tahhan, G, Valtzoglou, V, Williams, J, Eskander, P, Gash, K, Gourbault, L, Hanna, M, Maccabe, T, Newton, C, Olivier, J, Rozwadowski, S, Teh, E, West, D, Al-Omishy, H, Baig, M, Bates, H, Di Taranto, G, Dickson, K, Dunne, N, Gill, C, Howe, D, Jeevan, D, Khajuria, A, Martin-Ucar AMcEvoy, K, Naredla, P, Robertson, S, Sait, M, R Sarma, D, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, A Akhtar, M, Brunt, A, Mcintyre, J, Milne, K, M Rashid, M, Sgro, A, E Stewart, K, Turnbull, A, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Patki, P, Tanabalan, C, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, Macdonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Jones, R, S Kolli, V, K Lala, A, Leeson, S, Peevor, R, Seymour, Z, Chen, L, Henderson, E, Loehrer, A, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, Mcelhinney, K, Olson, K, C Osterberg, E, Riley, C, Srikanth, P, Thornhill, M, Blazer, D, Dilalla, G, S Hwang, E, Lee, W, Lidsky, M, Plichta, J, Rosenberger, L, Scheri, R, Turnage, K, Visgauss, J, Zani, S, Farma, J, Clark, J, Kwon, D, Etchill, E, E Gabre-Kidan AJenny, H, Kent, A, Ladd, M, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Brown, L, Ganly, I, Mullinax, J, Gusani, N, Hazelton, J, Maines, J, S Oh, J, Ssentongo, A, Ssentongo, P, Azam, M, Choudhry, A, Marx, W, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, K Abel, M, Andaya, V, Bigay, K, A Boeck, M, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, Bc, Heaton, C, Hirose, K, M Jablons, D, Kirkwood, K, Z Kornblith, L, R Kratz, J, Lee, R, N Miller, P, Nakakura, E, Nunez-Garcia, B, O'Donnell, R, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, M, Wai, K, Wustrack, R, J Xu, M, Beswick, D, Goddard, J, Manor, J, Song, J, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, L Roland, C, N Zafar, S, Abdallah, M, Abouassi, A, Almasri, M, Kulkarni, G, Marwan, H, Mehdi, M, Aoun, S, S Ban, V, H Batjer, H, Caruso, J, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, P, Hawkins, A, Maiga, A, Laufer, J, Scasso, S, Surgery, Graduate School, Glasbey, J, Nepogodiev, D, Simoes, J, Omar, O, Li, E, Abou Chaar, M, Chaudhry, D, Videria, J, Gujjuri, R, Kaafarani, H, Minaya-Bravo, A, Mckay, S, Roberts, K, Miguel-Mendez, C, Smart, N, Stewart, G, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), COVIDSurg Collaborative, Kolias, Angelos [0000-0003-3992-0587], Stewart, Grant [0000-0003-3188-9140], Apollo - University of Cambridge Repository, Glasbey JC, Nepogodiev D, Simoes JFF, Omar O, Li E, Venn ML, Pgdme, Abou Chaar MK, Capizzi V, Chaudhry D, Desai A, Edwards JG, Evans JP, Fiore M, Videria JF, Ford SJ, Ganly I, Griffiths EA, Gujjuri RR, Kolias AG, Kaafarani HMA, Minaya-Bravo A, McKay SC, Mohan HM, Roberts KJ, San Miguel-Méndez C, Pockney P, Shaw R, Smart NJ, Stewart GD, Sundar Mrcog S, Vidya R, Bhangu AA, COVIDSurg Collaborative, Palmerini Emanuela, Frisoni Tommaso, Donati Davide, A Belvedere, P Bernante, P Bertoglio, S Boussedra, E Brunocilla, R Cipriani, G Cisternino, E De Crescenzo, P De Iaco, G Dondi, F Frio, E Jovine, F Mineo Bianchi, J Neri, D Parlanti, A M Perrone, A P Pezzuto, M Pignatti, V Pinto, G Poggioli, M Ravaioli, M Rottoli, R Schiavina, M Serenari, M Serra, P Solli, M Taffurelli, M Tanzanu, M Tesei, T Violante, S Zanotti, V Tonini, M Cervellera, A Gori, L Sartarelli, Glasbey, James C, Simoes, Joana F F, Venn, Mary L, Pgdme, null, Abou Chaar, Mohammad K, Edwards, Jonathan G, Evans, Jonathan P, Videria, Jose Flavio, Ford, Samuel J, Griffiths, Ewen A, Gujjuri, Rohan R, Kolias, Angelos G, Kaafarani, Haytham M A, McKay, Siobhan C, Mohan, Helen M, Roberts, Keith J, Smart, Neil J, Stewart, Grant D, Sundar Mrcog, Sudha, and Bhangu, Aneel A, Toia, F
- Subjects
Male ,Cancer Research ,Outcome Assessment ,International Cooperation ,Settore MED/18 - CHIRURGIA GENERALE ,Settore MED/19 - Chirurgia Plastica ,030230 surgery ,Aged ,Aged, 80 and over ,COVID-19 ,Cohort Studies ,Critical Care ,Elective Surgical Procedures ,Epidemics ,Female ,Humans ,Logistic Models ,Middle Aged ,Neoplasms ,Outcome Assessment, Health Care ,Postoperative Complications ,SARS-CoV-2 ,0302 clinical medicine ,Operating theater ,cohort studies ,Health care ,middle aged ,80 and over ,Medicine ,Lung ,Cancer ,COVID-19/epidemiology ,OUTCOMES ,Manchester Cancer Research Centre ,Pulmonary Complication ,ORIGINAL REPORTS ,aged ,Oncology ,030220 oncology & carcinogenesis ,Pneumonia & Influenza ,Patient Safety ,Elective Surgical Procedure ,Life Sciences & Biomedicine ,6.4 Surgery ,Cohort study ,Human ,medicine.medical_specialty ,elective surgical procedures/methods ,Logistic Model ,Health Care ,Clinical Sciences ,Oncology and Carcinogenesis ,Epidemic ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,cancer surgery ,SARS-CoV-2 pandemic ,epidemics ,COVIDSurg Collaborative ,NO ,outcome assessment, health care/methods ,03 medical and health sciences ,male ,Settore MED/28 - Malattie Odontostomatologiche ,Clinical Research ,1112 Oncology and Carcinogenesis ,Oncology & Carcinogenesis ,Elective surgery ,Elective Cancer Surgery in SARS-CoV-2, Elective Cancer Surgery in COVID-19, covid 19, sars-cov-2 ,Science & Technology ,business.industry ,Prevention ,ResearchInstitutes_Networks_Beacons/mcrc ,Evaluation of treatments and therapeutic interventions ,1103 Clinical Sciences ,Pneumonia ,Odds ratio ,medicine.disease ,Good Health and Well Being ,neoplasms/surgery ,critical care/methods ,Emergency medicine ,postoperative complications/prevention & control ,Neoplasm ,Postoperative Complication ,Cohort Studie ,business ,aged, 80 and over ,SARS-CoV-2/physiology ,logistic models - Abstract
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks. Copyright © 2020 American Society of Clinical Oncology. All rights reserved. Bowel and Cancer Research; Sarcoma UK; Yorkshire Cancer Research; European Society of Coloproctology; National Institute for Health Research: 16.136.79; Bowel Disease Research Foundation; Urology Foundation Supported by a National Institute for Health Research (NIHR) Global Health Research Unit grant (NIHR 16.136.79) using UK aid from the UK government to support global health research, Association of Coloproctology of Great Britain and Ireland, Bowel & Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, The Urology Foundation, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research. The funders had no role in the study design; data collection, analysis, and interpretation; or writing of this report. The views expressed are those of the authors and not necessarily those of the National Health Service, NIHR, or UK Department of Health and Social Care.
- Published
- 2021
114. Study protocol on defining core outcomes and data elements in chronic subdural haematoma
- Author
-
D.C. (Dana) Holl, Aswin Chari, Christian Iorio-Morin, R. Dammers, Niels A. Van Der Gaag, Angelos G. Kolias, Peter J. Hutchinson, Ellie Edlmann, D.C. (Dana) Holl, Aswin Chari, Christian Iorio-Morin, R. Dammers, Niels A. Van Der Gaag, Angelos G. Kolias, Peter J. Hutchinson, and Ellie Edlmann
- Abstract
BACKGROUND: Core Outcome Sets (COSs) are necessary to standardize reporting in research studies. This is urgently required in the field of chronic subdural hemat
- Published
- 2021
- Full Text
- View/download PDF
115. Trial of Dexamethasone for Chronic Subdural Hematoma
- Author
-
Peter J, Hutchinson, Ellie, Edlmann, Diederik, Bulters, Ardalan, Zolnourian, Patrick, Holton, Nigel, Suttner, Kevin, Agyemang, Simon, Thomson, Ian A, Anderson, Yahia Z, Al-Tamimi, Duncan, Henderson, Peter C, Whitfield, Monica, Gherle, Paul M, Brennan, Annabel, Allison, Eric P, Thelin, Silvia, Tarantino, Beatrice, Pantaleo, Karen, Caldwell, Carol, Davis-Wilkie, Harry, Mee, Elizabeth A, Warburton, Garry, Barton, Aswin, Chari, Hani J, Marcus, Andrew T, King, Antonio, Belli, Phyo K, Myint, Ian, Wilkinson, Thomas, Santarius, Carole, Turner, Simon, Bond, Angelos G, Kolias, and Jonathan, Cook
- Subjects
Male ,Reoperation ,medicine.medical_specialty ,British Neurosurgical Trainee Research Collaborative and Dex-CSDH Trial Collaborators ,education ,Treatment outcome ,Administration, Oral ,030204 cardiovascular system & hematology ,Severity of Illness Index ,Dexamethasone ,03 medical and health sciences ,0302 clinical medicine ,Chronic subdural hematoma ,General & Internal Medicine ,Humans ,Medicine ,Disabled Persons ,030212 general & internal medicine ,Glucocorticoids ,11 Medical and Health Sciences ,Aged ,Independent research ,business.industry ,General Medicine ,Middle Aged ,Combined Modality Therapy ,Intention to Treat Analysis ,Treatment Outcome ,Multicenter study ,Research centre ,Hematoma, Subdural, Chronic ,Family medicine ,Female ,Social care ,business - Abstract
BACKGROUNDChronic subdural hematoma is a common neurologic disorder that is especially prevalent among older people. The effect of dexamethasone on outcomes in patients with chronic subdural hematoma has not been well studied.METHODSWe conducted a multicenter, randomized trial in the United Kingdom that enrolled adult patients with symptomatic chronic subdural hematoma. The patients were assigned in a 1:1 ratio to receive a 2-week tapering course of oral dexamethasone, starting at 8 mg twice daily, or placebo. The decision to surgically evacuate the hematoma was made by the treating clinician. The primary outcome was a score of 0 to 3, representing a favorable outcome, on the modified Rankin scale at 6 months after randomization; scores range from 0 (no symptoms) to 6 (death).RESULTSFrom August 2015 through November 2019, a total of 748 patients were included in the trial after randomization — 375 were assigned to the dexamethasone group and 373 to the placebo group. The mean age of the patients was 74 years, and 94% underwent surgery to evacuate their hematomas during the index admission; 60% in both groups had a score of 1 to 3 on the modified Rankin scale at admission. In a modified intention-to-treat analysis that excluded the patients who withdrew consent for participation in the trial or who were lost to follow-up, leaving a total of 680 patients, a favorable outcome was reported in 286 of 341 patients (83.9%) in the dexamethasone group and in 306 of 339 patients (90.3%) in the placebo group (difference, −6.4 percentage points [95% confidence interval, −11.4 to −1.4] in favor of the placebo group; P=0.01). Among the patients with available data, repeat surgery for recurrence of the hematoma was performed in 6 of 349 patients (1.7%) in the dexamethasone group and in 25 of 350 patients (7.1%) in the placebo group. More adverse events occurred in the dexamethasone group than in the placebo group.CONCLUSIONSAmong adults with symptomatic chronic subdural hematoma, most of whom had undergone surgery to remove their hematomas during the index admission, treatment with dexamethasone resulted in fewer favorable outcomes and more adverse events than placebo at 6 months, but fewer repeat operations were performed in the dexamethasone group. (Funded by the National Institute for Health Research Health Technology Assessment Programme; Dex-CSDH ISRCTN number, ISRCTN80782810. opens in new tab.)
- Published
- 2020
116. Improving Neurosurgery Education Using Social Media Case-Based Discussions: A Pilot Study
- Author
-
Nicola Newall, Brandon G. Smith, Oliver Burton, Aswin Chari, Angelos G. Kolias, Peter J. Hutchinson, Alexander Alamri, Chris Uff, Gideon Adegboyega, Meedie Ali, Sacha Chiuta, Gwenllian Evans, Patrick Hurley, Orla Mantle, Chidera Ota, Duranka Perera, Camilla Siig, and Staša Tumpa
- Subjects
Medical education ,HCP, Hydrocephalus ,medicine.medical_specialty ,RD1-811 ,GBM, Glioblastoma ,Neurosurgery ,CM, Cervical myelopathy ,Demographic data ,Public engagement ,TBI-CM, Traumatic brain injury–clinical management ,Social media ,Undergraduate curriculum ,LMICs, Low- and middle-income countries ,SDH, Subdural hematoma ,SoMe, Social media ,Brainbook ,medicine ,SAH - Subarachnoid hemorrhage ,RC346-429 ,SDH - Subdural hematoma ,CbD, Case-based discussion ,CES, Cauda equina syndrome ,COVID-19, Coronavirus disease 2019 ,TBI, Traumatic brain injury ,Medical school ,TBI-P, Traumatic brain injury–pathophysiology ,SAH, Subarachnoid hemorrhage ,Science dissemination ,Surgery ,Original Article ,Neurology (clinical) ,Neurology. Diseases of the nervous system ,EDH, Extradural hematoma ,Psychology - Abstract
Background The increasing shift toward a more generalized medical undergraduate curriculum has led to limited exposure to subspecialties, including neurosurgery. The lack of standardized teaching may result in insufficient coverage of core learning outcomes. Social media (SoMe) in medical education are becoming an increasingly accepted and popular way for students to meet learning objectives outside formal medical school teaching. We delivered a series of case-based discussions (CbDs) over SoMe to attempt to meet core learning needs in neurosurgery and determine whether SoMe-based CbDs were an acceptable method of education. Methods Twitter was used as a medium to host 9 CbDs pertaining to common neurosurgical conditions in practice. A sequence of informative and interactive tweets were formulated before live CbDs and tweeted in progressive order. Demographic data and participant feedback were collected. Results A total of 277 participants were recorded across 9 CbDs, with 654,584 impressions generated. Feedback responses were received from 135 participants (48.7%). Participants indicated an increase of 77% in their level of knowledge after participating. Of participants, 57% (n = 77) had previous CbD experience as part of traditional medical education, with 62% (n = 84) receiving a form of medical education previously through SoMe. All participants believed that the CbDs objectives were met and would attend future sessions. Of participants, 99% (n = 134) indicated that their expectations were met. Conclusions SoMe has been shown to be a favorable and feasible medium to host live, text-based interactive CbDs. SoMe is a useful tool for teaching undergraduate neurosurgery and is easily translatable to all domains of medicine and surgery.
- Published
- 2020
117. Robotic Semi-Automated Transcranial Doppler Assessment of Cerebrovascular Autoregulation in Post-Concussion Syndrome: Methodological Considerations
- Author
-
Marek Czosnyka, Karol P. Budohoski, Danyal Z. Khan, Adel Helmy, Michał M. Placek, Fahim Anwar, Peter J. Hutchinson, Manohar Bance, Peter Smielewski, Placek, Michal [0000-0001-7936-5202], Smielewski, Peter [0000-0001-5096-3938], Hutchinson, Peter [0000-0002-2796-1835], Bance, Manohar [0000-0001-8050-3617], Helmy, Adel [0000-0002-0531-0556], and Apollo - University of Cambridge Repository
- Subjects
medicine.medical_specialty ,Post-concussion syndrome ,Traumatic brain injury ,business.industry ,brain concussion ,traumatic brain injury ,cerebral blood flow ,Cognition ,General Medicine ,medicine.disease ,Cerebrovascular Circulation ,Transcranial Doppler ,Cerebral blood flow ,Cerebrovascular autoregulation ,Internal medicine ,Cardiology ,medicine ,Original Article ,post-concussion syndrome ,business ,cerebrovascular circulation - Abstract
Post-concussion syndrome (PCS) refers to a constellation of physical, cognitive, and emotional symptoms after traumatic brain injury (TBI). Despite its incidence and impact, the underlying mechanisms of PCS are unclear. We hypothesized that impaired cerebral autoregulation (CA) is a contributor. In this article, we present our protocol for non-invasively assessing CA in patients with TBI and PCS in a real-world clinical setting. A prospective, observational study was integrated into outpatient clinics at a tertiary neurosurgical center. Data points included: demographics, symptom profile (Post-Concussion Symptom Scale [PCSS]) and neuropsychological assessment (Cambridge Neuropsychological Test Automated-Battery [CANTAB]). Cerebrovascular metrics (nMxa co-efficient and the transient hyperaemic-response ratio [THRR]) were collected using transcranial Doppler (TCD), finger plethysmography, and bespoke software (ICM+). Twelve participants were initially recruited but 2 were excluded after unsuccessful insonation of the middle cerebral artery (MCA); 10 participants (5 patients with TBI, 5 healthy controls) were included in the analysis (median age 26.5 years, male to female ratio: 7:3). Median PCSS scores were 6/126 for the TBI patient sub-groups. Median CANTAB percentiles were 78 (healthy controls) and 25 (TBI). nMxa was calculated for 90% of included patients, whereas THRR was calculated for 50%. Median study time was 127.5 min and feedback (n = 6) highlighted the perceived acceptability of the study. This pilot study has demonstrated a reproducible assessment of PCS and CA metrics (non-invasively) in a real-world setting. This protocol is feasible and is acceptable to participants. By scaling this methodology, we hope to test whether CA changes are correlated with symptomatic PCS in patients post-TBI.
- Published
- 2020
118. Single Cell Sequencing Reveals Glial Specific Responses to Tissue Processing & Enzymatic Dissociation in Mice and Humans
- Author
-
Daniel J. Gaffney, Abdulraouf Abdulraouf, Naeem Nadaf, Adam Young, Peter J. Hutchinson, Tushar Kamath, Connor Dufort, Samuel E. Marsh, Lasse Dissing-Olesen, Evan Z. Macosko, Harry Bulstrode, Velina Kozareva, Beth Stevens, Robin J.M. Franklin, Soyon Hong, Alec J. Walker, Charles R. Vanderburg, Timothy R. Hammond, and Sarah Murphy
- Subjects
Transcriptome ,Cell type ,medicine.anatomical_structure ,Single cell sequencing ,Chemistry ,Gene expression ,Cell ,medicine ,Tissue Processing ,Human brain ,Ex vivo ,Cell biology - Abstract
A key aspect of nearly all single cell experiments is the necessity to dissociate intact tissues into single cell suspensions for processing. While many protocols have been optimized for optimal cell yield, they have often overlooked the effects that dissociation can have onex vivogene expression changes during this process. Microglia, the brain’s resident macrophages, are a highly dynamic population that are extremely sensitive to their microenvironment and have been shown to dramatically alter their transcriptome upon stimulation. We demonstrate that use of enzymatic dissociation methods on mouse central nervous system (CNS) tissue induces an aberrant gene expression signature in microglia that can significantly confound downstream analysis. To minimize this issue, we developed a flexible protocol, that can be used with existing enzymatic protocols for fresh tissue, to eliminate artifactual gene expression while allowing for increased cell type diversity and yield. We demonstrate efficacy of this protocol in analysis of diverse CNS cell types and sorted myeloid populations while using enzymatic dissociation. Generation of new and reanalysis of previously published human brain single nucleus RNAseq (snRNA-seq) datasets reveal that a similar signature is also present in post-mortem tissue. Through novel snRNA-seq analysis of acutely-resected neurosurgical tissue we demonstrate that this signature can be induced in human tissue due to technical differences in sample processing. These results provide key insight into the potential confounds of enzymatic digestion and provide a solution to allow for enzymatic digestion for scRNA-seq while avoidingex vivotranscriptional artifacts. Analysis of human tissue reveals potential for artifacts in current and future snRNA-seq datasets that will require deeper analysis and careful consideration to separate true biology from artifacts related to post-mortem processes.
- Published
- 2020
119. Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain
- Author
-
Samuel E. Marsh, Alec J. Walker, Tushar Kamath, Lasse Dissing-Olesen, Timothy R. Hammond, T. Yvanka de Soysa, Adam M. H. Young, Sarah Murphy, Abdulraouf Abdulraouf, Naeem Nadaf, Connor Dufort, Alicia C. Walker, Liliana E. Lucca, Velina Kozareva, Charles Vanderburg, Soyon Hong, Harry Bulstrode, Peter J. Hutchinson, Daniel J. Gaffney, David A. Hafler, Robin J. M. Franklin, Evan Z. Macosko, and Beth Stevens
- Subjects
Sequence Analysis, RNA ,General Neuroscience ,Brain ,Humans ,Microglia ,Single-Cell Analysis ,Transcriptome ,Neuroglia - Abstract
A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues into single-cell suspensions. While many protocols have been optimized for optimal cell yield, they have often overlooked the effects that dissociation can have on ex vivo gene expression. Here, we demonstrate that use of enzymatic dissociation on brain tissue induces an aberrant ex vivo gene expression signature, most prominently in microglia, which is prevalent in published literature and can substantially confound downstream analyses. To address this issue, we present a rigorously validated protocol that preserves both in vivo transcriptional profiles and cell-type diversity and yield across tissue types and species. We also identify a similar signature in postmortem human brain single-nucleus RNA-sequencing datasets, and show that this signature is induced in freshly isolated human tissue by exposure to elevated temperatures ex vivo. Together, our results provide a methodological solution for preventing artifactual gene expression changes during fresh tissue digestion and a reference for future deeper analysis of the potential confounding states present in postmortem human samples.
- Published
- 2020
120. Patterns and outcomes of neurosurgery in England over a five-year period: A national retrospective cohort study
- Author
-
Adam J. Wahba, David A. Cromwell, Peter J. Hutchinson, Ryan K. Mathew, and Nick Phillips
- Subjects
Adult ,Elective Surgical Procedures ,Neurosurgery ,Humans ,Surgery ,Hospital Mortality ,General Medicine ,Neurosurgical Procedures ,Retrospective Studies - Abstract
BACKGROUND: Neurosurgical practice has seen major changes over several decades. There are no recent evaluations of national neurosurgical practice. The aim of this observational study was to describe neurosurgical practice in England and to use outcomes to assess and benchmark the quality of care in neurosurgery. MATERIAL AND METHODS: This national retrospective cohort study analysed Hospital Episode Statistics (HES) data from April 2013 to March 2018 for all adult admissions with a specialty code for neurosurgery. The epidemiology of patients and RCS Charlson comorbidities were derived and procedure incidence rates per 100,000 person-years calculated. Post-operative outcomes for elective and non-elective patients included: median length of stay, the proportion of patients requiring additional inpatient neurosurgical procedures, the proportion of patients discharged to their usual address, and in-hospital mortality rates. RESULTS: During the 5-year study period, there were 371,418 admissions to neurosurgery. The proportion of admissions involving a neurosurgical procedure was 77.3% (n = 287,077). Of these, 45% were for cranial surgery and 37% for spinal. Overall, 68.3% were elective procedures. The incidence rates of most procedures were low (
- Published
- 2022
121. WSES consensus conference guidelines: monitoring and management of severe adult traumatic brain injury patients with polytrauma in the first 24 hours
- Author
-
Andrew W Kirkpatrick, Juan Sahuquillo, Federico Coccolini, Luca Ansaloni, Raul Coimbra, George C. Velmahos, Raimund Helbok, Edoardo Picetti, Philip F. Stahel, Rocco Armonda, Deepak Gupta, Sandra Rossi, Franco Servadei, Zsolt J. Balogh, Thomas M. Scalea, Francesco Minardi, Andrew I.R. Maas, Ari Leppäniemi, Sandro Rizoli, Maurizio Berardino, Ronald V. Maier, Marco Ceresoli, Pierre Bouzat, Fausto Catena, Massimo Sartelli, Randall M. Chesnut, Giuseppe Citerio, Gian Luca Baiocchi, Yasuhiro Otomo, Yoram Kluger, Gustavo Pereira Fraga, Peter J. Hutchinson, Fikri M. Abu-Zidan, Osvaldo Chiara, Dieter G. Weber, Andres M. Rubiano, Nino Stocchetti, Andras Buki, Ernest E. Moore, Salomone Di Saverio, Takahiro Kinoshita, Fabio Silvio Taccone, Walter L. Biffl, David O. Okonkwo, John Myburgh, Miklosh Bala, Tommaso Tonetti, Rubiano, Andrés M. [0000-0001-8931-3254], Hutchinson, Peter [0000-0002-2796-1835], Apollo - University of Cambridge Repository, Picetti, E, Rossi, S, Abu-Zidan, F, Ansaloni, L, Armonda, R, Baiocchi, G, Bala, M, Balogh, Z, Berardino, M, Biffl, W, Bouzat, P, Buki, A, Ceresoli, M, Chesnut, R, Chiara, O, Citerio, G, Coccolini, F, Coimbra, R, Di Saverio, S, Fraga, G, Gupta, D, Helbok, R, Hutchinson, P, Kirkpatrick, A, Kinoshita, T, Kluger, Y, Leppaniemi, A, Maas, A, Maier, R, Minardi, F, Moore, E, Myburgh, J, Okonkwo, D, Otomo, Y, Rizoli, S, Rubiano, A, Sahuquillo, J, Sartelli, M, Scalea, T, Servadei, F, Stahel, P, Stocchetti, N, Taccone, F, Tonetti, T, Velmahos, G, Weber, D, Catena, F, Citerio, Giuseppe [0000-0002-5374-3161], and Edoardo Picetti, Sandra Rossi, Fikri M. Abu-Zidan, Luca Ansaloni, Rocco Armonda, Gian Luca Baiocchi, Miklosh Bala, Zsolt J. Balogh, Maurizio Berardino, Walter L. Biffl, Pierre Bouzat, Andras Buki, Marco Ceresoli, Randall M. Chesnut, Osvaldo Chiara, Giuseppe Citerio, Federico Coccolini, Raul Coimbra, Salomone Di Saverio, Gustavo P. Fraga, Deepak Gupta, Raimund Helbok, Peter J. Hutchinson, Andrew W. Kirkpatrick, Takahiro Kinoshita, Yoram Kluger, Ari Leppaniemi, Andrew I. R. Maas, Ronald V. Maier, Francesco Minardi, Ernest E. Moore, John A. Myburgh, David O. Okonkwo, Yasuhiro Otomo, Sandro Rizoli, Andres M. Rubiano, Juan Sahuquillo, Massimo Sartelli, Thomas M. Scalea, Franco Servadei, Philip F. Stahel, Nino Stocchetti, Fabio S. Taccone, Tommaso Tonetti, George Velmahos, Dieter Weber, Fausto Catena
- Subjects
Adult ,medicine.medical_specialty ,Delphi Technique ,Monitoring ,Traumatic brain injury ,Bleeding ,Hemorrhage ,Management ,Polytrauma ,Consensus Development Conferences as Topic ,lcsh:Surgery ,Poison control ,Guidelines as Topic ,Review ,Suicide prevention ,Occupational safety and health ,03 medical and health sciences ,Traumatic brain injury, Polytrauma, Bleeding, Hemorrhage, Monitoring, Management ,0302 clinical medicine ,Injury prevention ,Brain Injuries, Traumatic ,medicine ,Humans ,Monitoring, Physiologic ,Lesiones traumáticas del encéfalo ,business.industry ,Multiple Trauma ,Head injury ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Human factors and ergonomics ,030208 emergency & critical care medicine ,lcsh:RD1-811 ,lcsh:RC86-88.9 ,medicine.disease ,Hipotensión ,3. Good health ,Patient Care Management ,General Surgery ,Emergency medicine ,Emergency Medicine ,Surgery ,Human medicine ,Encefalopatía traumática crónica ,business ,030217 neurology & neurosurgery - Abstract
The acute phase management of patients with severe traumatic brain injury (TBI) and polytrauma represents a major challenge. Guidelines for the care of these complex patients are lacking, and worldwide variability in clinical practice has been documented in recent studies. Consequently, the World Society of Emergency Surgery (WSES) decided to organize an international consensus conference regarding the monitoring and management of severe adult TBI polytrauma patients during the first 24 hours after injury. A modified Delphi approach was adopted, with an agreement cut-off of 70%. Forty experts in this field (emergency surgeons, neurosurgeons, and intensivists) participated in the online consensus process. Sixteen recommendations were generated, with the aim of promoting rational care in this difficult setting.
- Published
- 2019
122. Decompressive craniotomy: an international survey of practice
- Author
-
B Indira Devi, Faith C. Robertson, Franco Servadei, Midhun Mohan, Claire Karekezi, Tsegazeab Laeke Teklemariam, Wellingson Silva Paiva, Davi Jorge Fontoura Solla, Hugo Layard Horsfall, Angelos G. Kolias, Muhammad Mukhtar Khan, Tariq Khan, Amos O. Adeleye, Peter J. Hutchinson, and Andres M. Rubiano
- Subjects
Adult ,medicine.medical_specialty ,Decompressive Craniectomy ,Health Knowledge, Attitudes, Practice ,Traumatic brain injury ,medicine.medical_treatment ,Neurosurgery ,Original Article - Neurosurgery general ,Decompressive craniotomy ,Hinge craniotomy ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Surveys and Questionnaires ,Brain Injuries, Traumatic ,medicine ,Hematoma, Subdural, Acute ,Humans ,030212 general & internal medicine ,Stroke ,Craniotomy ,Neuroradiology ,Randomized Controlled Trials as Topic ,medicine.diagnostic_test ,business.industry ,Interventional radiology ,Middle Aged ,medicine.disease ,Neurosurgeons ,Emergency medicine ,Floating craniotomy ,Surgery ,Decompressive craniectomy ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Background Traumatic brain injury (TBI) and stroke have devastating consequences and are major global public health issues. For patients that require a cerebral decompression after suffering a TBI or stroke, a decompressive craniectomy (DC) is the most commonly performed operation. However, retrospective non-randomized studies suggest that a decompressive craniotomy (DCO; also known as hinge or floating craniotomy), where a bone flap is replaced but not rigidly fixed, has comparable outcomes to DC. The primary aim of this project was to understand the current extent of usage of DC and DCO for TBI and stroke worldwide. Method A questionnaire was designed and disseminated globally via emailing lists and social media to practicing neurosurgeons between June and November 2019. Results We received 208 responses from 60 countries [40 low- and middle-income countries (LMICs)]. DC is used more frequently than DCO, however, about one-quarter of respondents are using a DCO in more than 25% of their patients. The three top indications for a DCO were an acute subdural hematoma (ASDH) and a GCS of 9-12, ASDH with contusions and a GCS of 3-8, and ASDH with contusions and a GCS of 9-12. There were 8 DCO techniques used with the majority (60/125) loosely tying sutures to the bone flap. The majority (82%) stated that they were interested in collaborating on a randomized trial of DCO vs. DC. Conclusion Our results show that DCO is a procedure carried out for TBI and stroke, especially in LMICs, and most commonly for an ASDH. The majority of the respondents were interested in collaborating on a is a future randomized trial.
- Published
- 2020
123. Influence of Concomitant Extracranial Injury on Functional and Cognitive Recovery From Mild Versus Moderate to Severe Traumatic Brain Injury
- Author
-
Virginia F. J. Newcombe, Olli Tenovuo, Barbara J. Sahakian, Peter J. Hutchinson, Ellen L Carroll, Anne E Manktelow, Doris A. Chatfield, Joanne G. Outtrim, Lindsay Wilson, Jussi P. Posti, David K. Menon, Faye Forsyth, Outtrim, Joanne [0000-0001-8118-6430], Forsyth, Faye [0000-0003-2107-3690], Hutchinson, Peter [0000-0002-2796-1835], Sahakian, Barbara [0000-0001-7352-1745], Menon, David [0000-0002-3228-9692], Newcombe, Virginia [0000-0001-6044-9035], and Apollo - University of Cambridge Repository
- Subjects
Moderate to severe ,030506 rehabilitation ,Traumatic brain injury ,Nursing support ,Glasgow Outcome Scale ,Physical Therapy, Sports Therapy and Rehabilitation ,03 medical and health sciences ,0302 clinical medicine ,Cognition ,Nursing ,Brain Injuries, Traumatic ,medicine ,Humans ,Rehabilitation ,Emergency department ,Medical research ,medicine.disease ,Mental health ,United Kingdom ,nervous system diseases ,Patient recruitment ,nervous system ,Research centre ,Brain Injuries ,Quality of Life ,Neurology (clinical) ,0305 other medical science ,030217 neurology & neurosurgery - Abstract
Funding: This work was partially funded by a Medical Research Council (MRC, UK) Program Grant (Acute brain injury: heterogeneity of mechanisms, therapeutic targets and outcome effects [G9439390 ID 65883]), the European Commission under the 7th Framework Programme (FP7-270259-TBIcare), the UK National Institute of Health Research (NIHR) Biomedical Research Centre at Cambridge, the Technology Platform funding provided by the UK Department of Health and an Engineering and Physical Sciences Research Council (EPSRC, UK) Pathways to Impact award. PJH was supported by the NIHR (Research Professorship and Cambridge BRC). JPP received funding from Academy of Finland – Grant #322381, Government’s Special Financial Transfer tied to academic research in Health Sciences (Finland), the Emil Aaltonen Foundation, the Finnish Brain Foundation and the Maire Taponen Foundation. BJS receives funding from the NIHR Brain Injury MedTech Co-operative, Cambridge and the NIHR Cambridge Biomedical Research Centre (Mental Health Theme). DKM was supported by the NIHR through the NIHR Cambridge Biomedical Research Centre grant and a Senior Investigator Award. VFJN was funded by a Health Foundation/Academy of Medical Sciences Clinician Scientist Fellowship. Acknowledgements: The NIHR/Wellcome Trust Cambridge Clinical Research Facility provided nursing support to aid in the patient recruitment and data collection within the Emergency Department.
- Published
- 2020
124. Admission Levels of Interleukin 10 and Amyloid β 1–40 Improve the Outcome Prediction Performance of the Helsinki Computed Tomography Score in Traumatic Brain Injury
- Author
-
Jussi P. Posti, Riikka S. K. Takala, Rahul Raj, Teemu M. Luoto, Leire Azurmendi, Linnéa Lagerstedt, Mehrbod Mohammadian, Iftakher Hossain, Jessica Gill, Janek Frantzén, Mark van Gils, Peter J. Hutchinson, Ari J. Katila, Pia Koivikko, Henna-Riikka Maanpää, David K. Menon, Virginia F. Newcombe, Jussi Tallus, Kaj Blennow, Olli Tenovuo, Henrik Zetterberg, Jean-Charles Sanchez, Tampere University, Clinical Medicine, Department of Neurosciences and Rehabilitation, HUS Neurocenter, Helsinki University Hospital Area, Neurokirurgian yksikkö, Apollo - University of Cambridge Repository, Hutchinson, Peter [0000-0002-2796-1835], Menon, David [0000-0002-3228-9692], and Newcombe, Virginia [0000-0001-6044-9035]
- Subjects
medicine.medical_specialty ,EXTERNAL VALIDATION ,Amyloid β ,C-TERMINAL HYDROLASE-L1 ,Traumatic brain injury ,INCREASES ,interleukin 10 (IL10) ,panel analysis ,Computed tomography ,Gastroenterology ,S100B ,lcsh:RC346-429 ,CLASSIFICATION ,3124 Neurology and psychiatry ,outcome prediction ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,030212 general & internal medicine ,PLASMA-LEVELS ,lcsh:Neurology. Diseases of the nervous system ,Original Research ,FIBRILLARY ACIDIC PROTEIN ,Receiver operating characteristic ,medicine.diagnostic_test ,business.industry ,beta amyloid 1– ,traumatic brain injury ,Area under the curve ,3112 Neurosciences ,biomarkers ,Plasma levels ,medicine.disease ,3126 Surgery, anesthesiology, intensive care, radiology ,SERUM NEUROFILAMENT LIGHT ,3. Good health ,Helsinki CT score ,Interleukin 10 ,Neurology ,Neurology (clinical) ,TAU ,Outcome prediction ,business ,030217 neurology & neurosurgery ,beta amyloid 1–40 - Abstract
Background: Blood biomarkers may enhance outcome prediction performance of head computed tomography scores in traumatic brain injury (TBI). Objective: To investigate whether admission levels of eight different protein biomarkers can improve the outcome prediction performance of the Helsinki computed tomography score (HCTS) without clinical covariates in TBI. Materials and methods: Eighty-two patients with computed tomography positive TBIs were included in this study. Plasma levels of beta-amyloid isoforms 1-40 (A beta 40) and 1-42 (A beta 42), glial fibrillary acidic protein, heart fatty acid-binding protein, interleukin 10 (IL-10), neurofilament light, S100 calcium-binding protein B, and total tau were measured within 24 h from admission. The patients were divided into favorable (Glasgow Outcome Scale-Extended 5-8, n = 49) and unfavorable (Glasgow Outcome Scale-Extended 1-4, n = 33) groups. The outcome was assessed 6-12 months after injury. An optimal predictive panel was investigated with the sensitivity set at 90-100%. Results: The HCTS alone yielded a sensitivity of 97.0% (95% CI: 90.9-100) and specificity of 22.4% (95% CI: 10.2-32.7) and partial area under the curve of the receiver operating characteristic of 2.5% (95% CI: 1.1-4.7), in discriminating patients with favorable and unfavorable outcomes. The threshold to detect a patient with unfavorable outcome was an HCTS > 1. The three best individually performing biomarkers in outcome prediction were A beta 40, A beta 42, and neurofilament light. The optimal panel included IL-10, A beta 40, and the HCTS reaching a partial area under the curve of the receiver operating characteristic of 3.4% (95% CI: 1.7-6.2) with a sensitivity of 90.9% (95% CI: 81.8-100) and specificity of 59.2% (95% CI: 40.8-69.4). Conclusion: Admission plasma levels of IL-10 and A beta 40 significantly improve the prognostication ability of the HCTS after TBI.
- Published
- 2020
125. Bedside EEG predicts longitudinal behavioural changes in disorders of consciousness
- Author
-
Peter J. Hutchinson, Judith Allanson, John D. Pickard, Srivas Chennu, David K. Menon, Corinne A. Bareham, Neil Roberts, Hutchinson, Peter [0000-0002-2796-1835], Pickard, John [0000-0002-5762-6667], and Apollo - University of Cambridge Repository
- Subjects
medicine.medical_specialty ,animal structures ,Consciousness ,Cognitive Neuroscience ,Disorders of consciousness ,Electroencephalography ,lcsh:Computer applications to medicine. Medical informatics ,lcsh:RC346-429 ,050105 experimental psychology ,Clinical knowledge ,03 medical and health sciences ,Functional brain ,0302 clinical medicine ,Physical medicine and rehabilitation ,otorhinolaryngologic diseases ,medicine ,Humans ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,EEG ,Coma ,skin and connective tissue diseases ,lcsh:Neurology. Diseases of the nervous system ,medicine.diagnostic_test ,business.industry ,05 social sciences ,Regular Article ,respiratory system ,medicine.disease ,Prognosis ,Natural history studies (prognosis) ,Cross-Sectional Studies ,Neurology ,Cohort ,lcsh:R858-859.7 ,Consciousness Disorders ,sense organs ,Neurology (clinical) ,medicine.symptom ,Canonical correlation ,Nursing homes ,business ,030217 neurology & neurosurgery - Abstract
Highlights • pDOC patients are assessed for 2-years longitudinally with both the CRS-R and EEG. • Theta power and alpha clustering correlated strongest with changes in CRS-R scores. • EEG combined with CRS-R improved predictive power of future CRS-R scores. • Early changes in EEG outperformed early changes in CRS-R in terms of prognostic power. • Regular and repeated bedside EEG is feasible and has clinical utility for pDOC., Providing an accurate prognosis for prolonged disorder of consciousness (pDOC) patients remains a clinical challenge. Large cross-sectional studies have demonstrated the diagnostic and prognostic value of functional brain networks measured using high-density electroencephalography (hdEEG). Nonetheless, the prognostic value of these neural measures has yet to be assessed by longitudinal follow-up. We address this gap by assessing the utility of hdEEG to prognosticate long-term behavioural outcome, employing longitudinal data collected from a cohort of patients assessed systematically with resting hdEEG and the Coma Recovery Scale-Revised (CRS-R) at the bedside over a period of two years. We used canonical correlation analysis to relate clinical (including CRS-R scores combined with demographic variables) and hdEEG variables to each other. This analysis revealed that the patient’s age, and the hdEEG theta band power and alpha band connectivity, contributed most significantly to the relationship between hdEEG and clinical variables. Further, we found that hdEEG measures recorded at the time of assessment augmented clinical measures in predicting CRS-R scores at the next assessment. Moreover, the rate of hdEEG change not only predicted later changes in CRS-R scores, but also outperformed clinical measures in terms of prognostic power. Together, these findings suggest that improvements in functional brain networks precede changes in behavioural awareness in pDOC. We demonstrate here that bedside hdEEG assessments conducted at specialist nursing homes are feasible, have clinical utility, and can complement clinical knowledge and systematic behavioural assessments to inform prognosis and care.
- Published
- 2020
- Full Text
- View/download PDF
126. Chest Computed Tomography for the Diagnosis of COVID-19 in Emergency Trauma Surgery Patients Who Require Urgent Care During the Pandemic: Protocol for an Umbrella Review (Preprint)
- Author
-
Dylan Griswold, Andrés Gempeler, Gail Rosseau, Neema Kaseje, Walter D Johnson, Angelos Kolias, Peter J Hutchinson, and Andres M Rubiano
- Abstract
BACKGROUND Many health care facilities in low- and middle-income countries are inadequately resourced. COVID-19 has the potential to decimate surgical health care services unless health systems take stringent measures to protect health care workers from viral exposure and ensure the continuity of specialized care for patients. Among these measures, the timely diagnosis of COVID-19 is paramount to ensure the use of protective measures and isolation of patients to prevent transmission to health care personnel caring for patients with an unknown COVID-19 status or contact during the pandemic. Besides molecular and antibody tests, chest computed tomography (CT) has been assessed as a potential tool to aid in the screening or diagnosis of COVID-19 and could be valuable in the emergency care setting. OBJECTIVE This paper presents the protocol for an umbrella review that aims to identify and summarize the available literature on the diagnostic accuracy of chest CT for COVID-19 in trauma surgery patients requiring urgent care. The objective is to inform future recommendations on emergency care for this category of patients. METHODS We will conduct several searches in the L·OVE (Living Overview of Evidence) platform for COVID-19, a system that performs automated regular searches in PubMed, Embase, Cochrane Central Register of Controlled Trials, and over 30 other sources. The search results will be presented according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis). This review will preferentially consider systematic reviews of diagnostic test accuracy studies, as well as individual studies of such design, if not included in the systematic reviews, that assessed the sensitivity and specificity of chest CT in emergency trauma surgery patients. Critical appraisal of the included studies for risk of bias will be conducted. Data will be extracted using a standardized data extraction tool. Findings will be summarized narratively, and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach will be used to grade the certainty of evidence. RESULTS Ethics approval is not required for this systematic review, as there will be no patient involvement. The search for this systematic review commenced in October 2020, and we expect to publish the findings in early 2021. The plan for dissemination is to publish the findings in a peer-reviewed journal and present our results at conferences that engage the most pertinent stakeholders. CONCLUSIONS During the COVID-19 pandemic, protecting health care workers from infection is essential. Up-to-date information on the efficacy of diagnostic tests for detecting COVID-19 is essential. This review will serve an important role as a thorough summary to inform evidence-based recommendations on establishing effective policy and clinical guideline recommendations. CLINICALTRIAL PROSPERO International Prospective Register of Systematic Reviews CRD42020198267; https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=198267 INTERNATIONAL REGISTERED REPORT PRR1-10.2196/25207
- Published
- 2020
127. Personal protective equipment for reducing the risk of COVID-19 infection among healthcare workers involved in emergency trauma surgery during the pandemic: a systematic review protocol
- Author
-
Andres M. Rubiano, Peter J. Hutchinson, Dylan Griswold, Angelos G. Kolias, and Andrés Gempeler
- Subjects
Protocol (science) ,Critical appraisal ,Systematic review ,Data extraction ,business.industry ,Health care ,medicine ,Medical emergency ,business ,Grading (education) ,medicine.disease ,Trauma surgery ,Personal protective equipment - Abstract
ObjectiveThe objective of this broad evidence synthesis is to identify and summarize the available literature regarding the efficacy of different personal protective equipment (PPE) for reducing the risk of COVID-19 infection in health personnel caring for patients undergoing trauma surgery in low-resource environments (LREs).IntroductionMany healthcare facilities in low-and middle-income countries are inadequately resourced and may lack optimal organization and governance, especially concerning surgical health systems. COVID-19 has the potential to decimate these already strained surgical healthcare services unless health systems take stringent measures to protect healthcare workers from viral exposure and ensure the continuity of specialized care for the patients.Inclusion criteriaThis review will preferentially consider systematic reviews of experimental and quasi-experimental studies, as well as individual studies of such designs, evaluating the effect of different PPE on the risk of COVID-19 infection in healthcare workers (HCWs) involved in emergency trauma surgery.MethodsWe will conduct several searches in the L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that performs automated regular searches in PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and over thirty other sources. The search results will be presented according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram. Critical appraisal of the eligible studies for methodological quality will be conducted. Data will be extracted using the standardized data extraction tool in Covidence. Studies will, when possible, be pooled in a statistical meta-analysis using JBI SUMARI. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach for grading the certainty of evidence will be followed, and a Summary of Findings (SoF) will be created.Systematic review registration numberCRD42020198267
- Published
- 2020
128. Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study
- Author
-
Roel P.J. van Wijk, Jeroen T.J.M. van Dijck, Marjolein Timmers, Ernest van Veen, Giuseppe Citerio, Hester F. Lingsma, Andrew I.R. Maas, David K. Menon, Wilco C. Peul, Nino Stocchetti, Erwin J.O. Kompanje, Cecilia Åkerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Anna Antoni, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Pál Barzó, Romuald Beauvais, Ronny Beer, Bo-Michael Bellander, Antonio Belli, Habib Benali, Maurizio Berardino, Luigi Beretta, Morten Blaabjerg, Peter Bragge, Alexandra Brazinova, Vibeke Brinck, Joanne Brooker, Camilla Brorsson, Andras Buki, Monika Bullinger, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Iris Ceyisakar, Mark Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Amra Čović, Nicola Curry, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Helen Dawes, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Đula Đilvesi, Abhishek Dixit, Emma Donoghue, Jens Dreier, Guy-Loup Dulière, Ari Ercole, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Valery L. Feigin, Kelly Foks, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Dashiell Gantner, Guoyi Gao, Pradeep George, Alexandre Ghuysen, Lelde Giga, Ben Glocker, Jagoš Golubovic, Pedro A. Gomez, Johannes Gratz, Benjamin Gravesteijn, Francesca Grossi, Russell L. Gruen, Deepak Gupta, Juanita A. Haagsma, Iain Haitsma, Raimund Helbok, Eirik Helseth, Lindsay Horton, Jilske Huijben, Peter J. Hutchinson, Bram Jacobs, Stefan Jankowski, Mike Jarrett, Ji-Yao Jiang, Faye Johnson, Kelly Jones, Mladen Karan, Angelos G. Kolias, Erwin Kompanje, Daniel Kondziella, Evgenios Koraropoulos, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Linda Lanyon, Steven Laureys, Fiona Lecky, Didier Ledoux, Rolf Lefering, Valerie Legrand, Aurelie Lejeune, Leon Levi, Roger Lightfoot, Hester Lingsma, Ana M. Castaño-León, Marc Maegele, Marek Majdan, Alex Manara, Geoffrey Manley, Costanza Martino, Hugues Maréchal, Julia Mattern, Catherine McMahon, Béla Melegh, David Menon, Tomas Menovsky, Benoit Misset, Davide Mulazzi, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Daan Nieboer, József Nyirádi, Otesile Olubukola, Matej Oresic, Fabrizio Ortolano, Aarno Palotie, Paul M. Parizel, Jean-François Payen, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Matti Pirinen, Horia Ples, Suzanne Polinder, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Malinka Rambadagalla, Jonathan Rhodes, Sylvia Richardson, Sophie Richter, Samuli Ripatti, Saulius Rocka, Cecilie Roe, Olav Roise, Jonathan Rosand, Jeffrey V. Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Daniel Rueckert, Martin Rusnák, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Janos Sandor, Nadine Schäfer, Silke Schmidt, Herbert Schoechl, Guus Schoonman, Rico Frederik Schou, Elisabeth Schwendenwein, Charlie Sewalt, Toril Skandsen, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Simon Stanworth, Robert Stevens, William Stewart, Ewout W. Steyerberg, Nina Sundström, Anneliese Synnot, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Mark Steven Taylor, Braden Te Ao, Olli Tenovuo, Alice Theadom, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Peter Vajkoczy, Shirley Vallance, Egils Valeinis, Zoltán Vámos, Gregory Van der Steen, Joukje van der Naalt, Thomas A. van Essen, Wim Van Hecke, Caroline van Heugten, Dominique Van Praag, Thijs Vande Vyvere, Alessia Vargiolu, Emmanuel Vega, Kimberley Velt, Jan Verheyden, Paul M. Vespa, Anne Vik, Rimantas Vilcinis, Victor Volovici, Nicole von Steinbüchel, Daphne Voormolen, Petar Vulekovic, Kevin K.W. Wang, Eveline Wiegers, Guy Williams, Lindsay Wilson, Stefan Winzeck, Stefan Wolf, Zhihui Yang, Peter Ylén, Alexander Younsi, Frederick A. Zeiler, Veronika Zelinkova, Agate Ziverte, Tommaso Zoerle, Molecular Neuroscience and Ageing Research (MOLAR), CENTER-TB1 Investigators, Intensive Care, Public Health, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Institute for Molecular Medicine Finland, Genomics of Neurological and Neuropsychiatric Disorders, University of Helsinki, HUS Neurocenter, Neurokirurgian yksikkö, Helsinki University Hospital Area, Statistical and population genetics, Biostatistics Helsinki, Staff Services, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, van Wijk, R, van Dijck, J, Timmers, M, van Veen, E, Citerio, G, Lingsma, H, Maas, A, Menon, D, Peul, W, Stocchetti, N, Kompanje, E, Åkerlund, C, Amrein, K, Andelic, N, Andreassen, L, Anke, A, Antoni, A, Audibert, G, Azouvi, P, Azzolini, M, Bartels, R, Barzó, P, Beauvais, R, Beer, R, Bellander, B, Belli, A, Benali, H, Berardino, M, Beretta, L, Blaabjerg, M, Bragge, P, Brazinova, A, Brinck, V, Brooker, J, Brorsson, C, Buki, A, Bullinger, M, Cabeleira, M, Caccioppola, A, Calappi, E, Calvi, M, Cameron, P, Lozano, G, Carbonara, M, Cavallo, S, Chevallard, G, Chieregato, A, Ceyisakar, I, Coburn, M, Coles, J, Cooper, J, Correia, M, Čović, A, Curry, N, Czeiter, E, Czosnyka, M, Dahyot-Fizelier, C, Dark, P, Dawes, H, De Keyser, V, Degos, V, Corte, F, den Boogert, H, Depreitere, B, Đilvesi, Đ, Dixit, A, Donoghue, E, Dreier, J, Dulière, G, Ercole, A, Esser, P, Ezer, E, Fabricius, M, Feigin, V, Foks, K, Frisvold, S, Furmanov, A, Gagliardo, P, Galanaud, D, Gantner, D, Gao, G, George, P, Ghuysen, A, Giga, L, Glocker, B, Golubovic, J, Gomez, P, Gratz, J, Gravesteijn, B, Grossi, F, Gruen, R, Gupta, D, Haagsma, J, Haitsma, I, Helbok, R, Helseth, E, Horton, L, Huijben, J, Hutchinson, P, Jacobs, B, Jankowski, S, Jarrett, M, Jiang, J, Johnson, F, Jones, K, Karan, M, Kolias, A, Kondziella, D, Koraropoulos, E, Koskinen, L, Kovács, N, Kowark, A, Lagares, A, Lanyon, L, Laureys, S, Lecky, F, Ledoux, D, Lefering, R, Legrand, V, Lejeune, A, Levi, L, Lightfoot, R, Castaño-León, A, Maegele, M, Majdan, M, Manara, A, Manley, G, Martino, C, Maréchal, H, Mattern, J, Mcmahon, C, Melegh, B, Menovsky, T, Misset, B, Mulazzi, D, Muraleedharan, V, Murray, L, Negru, A, Nelson, D, Newcombe, V, Nieboer, D, Nyirádi, J, Olubukola, O, Oresic, M, Ortolano, F, Palotie, A, Parizel, P, Payen, J, Perera, N, Perlbarg, V, Persona, P, Piippo-Karjalainen, A, Pirinen, M, Ples, H, Polinder, S, Pomposo, I, Posti, J, Puybasset, L, Radoi, A, Ragauskas, A, Raj, R, Rambadagalla, M, Rhodes, J, Richardson, S, Richter, S, Ripatti, S, Rocka, S, Roe, C, Roise, O, Rosand, J, Rosenfeld, J, Rosenlund, C, Rosenthal, G, Rossaint, R, Rossi, S, Rueckert, D, Rusnák, M, Sahuquillo, J, Sakowitz, O, Sanchez-Porras, R, Sandor, J, Schäfer, N, Schmidt, S, Schoechl, H, Schoonman, G, Schou, R, Schwendenwein, E, Sewalt, C, Skandsen, T, Smielewski, P, Sorinola, A, Stamatakis, E, Stanworth, S, Stevens, R, Stewart, W, Steyerberg, E, Sundström, N, Synnot, A, Takala, R, Tamás, V, Tamosuitis, T, Taylor, M, Ao, B, Tenovuo, O, Theadom, A, Thomas, M, Tibboel, D, Tolias, C, Trapani, T, Tudora, C, Vajkoczy, P, Vallance, S, Valeinis, E, Vámos, Z, Van der Steen, G, van der Naalt, J, van Essen, T, Van Hecke, W, van Heugten, C, Van Praag, D, Vyvere, T, Vargiolu, A, Vega, E, Velt, K, Verheyden, J, Vespa, P, Vik, A, Vilcinis, R, Volovici, V, von Steinbüchel, N, Voormolen, D, Vulekovic, P, Wang, K, Wiegers, E, Williams, G, Wilson, L, Winzeck, S, Wolf, S, Yang, Z, Ylén, P, Younsi, A, Zeiler, F, Zelinkova, V, Ziverte, A, Zoerle, T, van Wijk, R. P. J., van Dijck, J. T. J. M., Timmers, M., van Veen, E., Citerio, G., Lingsma, H. F., Maas, A. I. R., Menon, D. K., Peul, W. C., Stocchetti, N., Kompanje, E. J. O., Akerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzo, P., Beauvais, R., Beer, R., Bellander, B. -M., Belli, A., Benali, H., Berardino, M., Beretta, L., Blaabjerg, M., Bragge, P., Brazinova, A., Brinck, V., Brooker, J., Brorsson, C., Buki, A., Bullinger, M., Cabeleira, M., Caccioppola, A., Calappi, E., Calvi, M. R., Cameron, P., Lozano, G. C., Carbonara, M., Cavallo, S., Chevallard, G., Chieregato, A., Ceyisakar, I., Coburn, M., Coles, J., Cooper, J. D., Correia, M., Covic, A., Curry, N., Czeiter, E., Czosnyka, M., Dahyot-Fizelier, C., Dark, P., Dawes, H., De Keyser, V., Degos, V., Corte, F. D., den Boogert, H., Depreitere, B., Dilvesi, D., Dixit, A., Donoghue, E., Dreier, J., Duliere, G. -L., Ercole, A., Esser, P., Ezer, E., Fabricius, M., Feigin, V. L., Foks, K., Frisvold, S., Furmanov, A., Gagliardo, P., Galanaud, D., Gantner, D., Gao, G., George, P., Ghuysen, A., Giga, L., Glocker, B., Golubovic, J., Gomez, P. A., Gratz, J., Gravesteijn, B., Grossi, F., Gruen, R. L., Gupta, D., Haagsma, J. A., Haitsma, I., Helbok, R., Helseth, E., Horton, L., Huijben, J., Hutchinson, P. J., Jacobs, B., Jankowski, S., Jarrett, M., Jiang, J. -Y., Johnson, F., Jones, K., Karan, M., Kolias, A. G., Kompanje, E., Kondziella, D., Koraropoulos, E., Koskinen, L. -O., Kovacs, N., Kowark, A., Lagares, A., Lanyon, L., Laureys, S., Lecky, F., Ledoux, D., Lefering, R., Legrand, V., Lejeune, A., Levi, L., Lightfoot, R., Lingsma, H., Castano-Leon, A. M., Maegele, M., Majdan, M., Manara, A., Manley, G., Martino, C., Marechal, H., Mattern, J., Mcmahon, C., Melegh, B., Menon, D., Menovsky, T., Misset, B., Mulazzi, D., Muraleedharan, V., Murray, L., Negru, A., Nelson, D., Newcombe, V., Nieboer, D., Nyiradi, J., Olubukola, O., Oresic, M., Ortolano, F., Palotie, A., Parizel, P. M., Payen, J. -F., Perera, N., Perlbarg, V., Persona, P., Peul, W., Piippo-Karjalainen, A., Pirinen, M., Ples, H., Polinder, S., Pomposo, I., Posti, J. P., Puybasset, L., Radoi, A., Ragauskas, A., Raj, R., Rambadagalla, M., Rhodes, J., Richardson, S., Richter, S., Ripatti, S., Rocka, S., Roe, C., Roise, O., Rosand, J., Rosenfeld, J. V., Rosenlund, C., Rosenthal, G., Rossaint, R., Rossi, S., Rueckert, D., Rusnak, M., Sahuquillo, J., Sakowitz, O., Sanchez-Porras, R., Sandor, J., Schafer, N., Schmidt, S., Schoechl, H., Schoonman, G., Schou, R. F., Schwendenwein, E., Sewalt, C., Skandsen, T., Smielewski, P., Sorinola, A., Stamatakis, E., Stanworth, S., Stevens, R., Stewart, W., Steyerberg, E. W., Sundstrom, N., Synnot, A., Takala, R., Tamas, V., Tamosuitis, T., Taylor, M. S., Ao, B. T., Tenovuo, O., Theadom, A., Thomas, M., Tibboel, D., Tolias, C., Trapani, T., Tudora, C. M., Vajkoczy, P., Vallance, S., Valeinis, E., Vamos, Z., Van der Steen, G., van der Naalt, J., van Essen, T. A., Van Hecke, W., van Heugten, C., Van Praag, D., Vyvere, T. V., Vargiolu, A., Vega, E., Velt, K., Verheyden, J., Vespa, P. M., Vik, A., Vilcinis, R., Volovici, V., von Steinbuchel, N., Voormolen, D., Vulekovic, P., Wang, K. K. W., Wiegers, E., Williams, G., Wilson, L., Winzeck, S., Wolf, S., Yang, Z., Ylen, P., Younsi, A., Zeiler, F. A., Zelinkova, V., Ziverte, A., and Zoerle, T.
- Subjects
Patient Consent ,MULTICENTER ,Critical Care and Intensive Care Medicine ,Patient Admission ,0302 clinical medicine ,Traumatic brain injury ,Informed consent ,Surveys and Questionnaires ,Brain Injuries, Traumatic ,Prospective Studies ,Israel ,media_common ,CAPACITY ASSESSMENT ,OUTCOMES ,RESUSCITATION RESEARCH ,PROXY CONSENT ,Member states ,Research Personnel ,humanities ,3. Good health ,Europe ,Intensive Care Units ,Policy ,medicine.medical_specialty ,Concordance ,TRAUMATIC BRAIN-INJURY ,Legislation ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,medicine ,Humans ,media_common.cataloged_instance ,In patient ,European Union ,European union ,Ethics ,SURROGATE DECISION-MAKERS ,business.industry ,030208 emergency & critical care medicine ,3126 Surgery, anesthesiology, intensive care, radiology ,Proxy ,Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10] ,Human Experimentation ,030228 respiratory system ,Family medicine ,3121 General medicine, internal medicine and other clinical medicine ,DEFERRED CONSENT ,Observational study ,Human medicine ,business ,Follow-Up Studies - Abstract
PurposeEnrolling traumatic brain injury (TBI) patients with an inability to provide informed consent in research is challenging. Alternatives to patient consent are not sufficiently embedded in European and national legislation, which allows procedural variation and bias. We aimed to quantify variations in informed consent policy and practice.MethodsVariation was explored in the CENTER-TBI study. Policies were reported by using a questionnaire and national legislation. Data on used informed consent procedures were available for 4498 patients from 57 centres across 17 European countries.ResultsVariation in the use of informed consent procedures was found between and within EU member states. Proxy informed consent (N=1377;64%) was the most frequently used type of consent in the ICU, followed by patient informed consent (N=426;20%) and deferred consent (N=334;16%). Deferred consent was only actively used in 15 centres (26%), although it was considered valid in 47 centres (82%).ConclusionsAlternatives to patient consent are essential for TBI research. While there seems to be concordance amongst national legislations, there is regional variability in institutional practices with respect to the use of different informed consent procedures. Variation could be caused by several reasons, including inconsistencies in clear legislation or knowledge of such legislation amongst researchers.
- Published
- 2020
129. Personal protective equipment for reducing the risk of COVID-19 infection among healthcare workers involved in emergency trauma surgery during the pandemic: an umbrella review
- Author
-
Andres M. Rubiano, Peter J. Hutchinson, Andrés Gempeler, Dylan Griswold, and Angelos G. Kolias
- Subjects
medicine.medical_specialty ,business.product_category ,business.industry ,Systematic review ,Data extraction ,Health care ,Pandemic ,Medicine ,Observational study ,Respirator ,business ,Intensive care medicine ,Personal protective equipment ,Trauma surgery - Abstract
ObjectiveThe objective of this review was to summarise the effects of different personal protective equipment (PPE) for reducing the risk of COVID-19 infection in health personnel caring for patients undergoing trauma surgery. The purpose of the review was to inform recommendations for rational use of PPE for emergency surgery staff, particularly in low resources environments where PPE shortages and high costs are expected to hamper the safety of healthcare workers (HCWs) and affect the care of trauma patients.IntroductionMany healthcare facilities in low-and middle-income countries are inadequately resourced. COVID-19 has the potential to decimate these already strained surgical healthcare services unless health systems take stringent measures to protect healthcare workers from viral exposure.Inclusion criteriaThis review included systematic reviews, experimental and observational studies evaluating the effect of different PPE on the risk of COVID-19 infection in HCWs involved in emergency trauma surgery. Indirect evidence from other healthcare settings was considered, as well as evidence from other viral outbreaks summarised and discussed for the COVID-19 pandemic.MethodsWe conducted searches in the L·OVE (Living OVerview of Evidence) platform for COVID-19, a system that performs automated regular searches in PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and over thirty other sources. The risk of bias assessment of the included studies was planned with the AMSTAR II tool for systematic reviews, the RoBII tool for randomised controlled trials, and the ROBINS-I tool for non-randomised studies. Data were extracted using a standardised data extraction tool and summarised narratively. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach for grading the certainty of the evidence was followed.ResultsWe identified 17 systematic reviews that fulfilled our selection criteria and were included for synthesis. We did not identify randomised controlled trials during COVID-19 or studies additional to those included in the reviews that discussed other similar viral respiratory illnesses.ConclusionsThe use of PPE drastically reduces the risk of COVID-19 compared with no mask use in HCWs in the hospital setting. N95 and N95 equivalent respirators provided more protection and were found to halve the risk of COVID-19 contagion in HCWs from moderate and high-risk environments. Eye protection also offers additional security and is associated with reduced incidence of contagion. These effects apply to emergency trauma care. Decontamination and reuse appear as feasible, cost-effective measures that would likely help overcome PPE shortages and enhance the allocation of limited resources.SUMMARY OF FINDINGSThere is high certainty that the use of N95 respirators and surgical masks are associated with a reduced risk of coronaviruses respiratory illness when compared with no mask use. In moderate to high-risk environments, especially in aerosol-generating procedures, N95 respirators are associated with a more significant reduction in risk of COVID-19 infection compared with surgical masks. Eye protection also reduces the risk of contagion.Decontamination of masks and respirators with ultraviolet germicidal irradiation, vaporous hydrogen peroxide, or dry heat is effective and does not affect PPE performance or fit.(Figure 1: GRADE summary of findings)
- Published
- 2020
130. Effects of Age and Sex on Optic Nerve Sheath Diameter in Healthy Volunteers and Patients With Traumatic Brain Injury
- Author
-
Danilo Cardim, Marek Czosnyka, Karthikka Chandrapatham, Rafael Badenes, Alessandro Bertuccio, Anna Di Noto, Joseph Donnelly, Paolo Pelosi, Lorenzo Ball, Peter J. Hutchinson, Chiara Robba, Apollo - University of Cambridge Repository, and Hutchinson, Peter [0000-0002-2796-1835]
- Subjects
medicine.medical_specialty ,Neurology ,Traumatic brain injury ,medicine.medical_treatment ,intracranial pressure ,Age and sex ,lcsh:RC346-429 ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,optic nerve sheath diameter ,Healthy volunteers ,Medicine ,Intubation ,Young adult ,lcsh:Neurology. Diseases of the nervous system ,Original Research ,Intracranial pressure ,business.industry ,healthy volunteers ,traumatic brain injury ,ultrasonography ,030208 emergency & critical care medicine ,medicine.disease ,Anesthesia ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
The measurement of optic nerve sheath diameter (ONSD) has been reported as a non-invasive marker for intracranial pressure (ICP). Nevertheless, it is uncertain whether possible ONSD differences occur with age and sex in healthy and brain-injured populations. The aim of this study was to investigate the effects of sex and age on ONSD in healthy volunteers and patients with traumatic brain injury. We prospectively included 122 healthy adult volunteers (Galliera Hospital, Genova, Italy), and compared age/sex dependence of ONSD to 95 adult patients (Addenbrooke's Hospital, Cambridge, UK) with severe traumatic brain injury (TBI) requiring intubation and invasive ICP monitoring. The two groups were stratified for sex and age. Age was divided into 3 subgroups: (1) young adults: 18–44 years; (2) middle-aged adults: 45–64 years; (3) old adults: >65 years. In healthy volunteers, ONSD was significantly different between males and females [median (interquartile range): 4.2 (3.9–4.6) mm vs. 4.1 (3.6–4.2) mm (p = 0.01), respectively] and was correlated with age (R = 0.50, p < 0.0001). ONSD was significantly increased in group 3 compared to groups 2 and 1, indicating that ONSD values are higher in elderly subjects. In TBI patients, no differences in ONSD were found for sex and the correlation between ONSD and age was non-significant (R = 0.13, p = 0.20). ONSD increases with age and is significantly larger for males in healthy volunteers but not in TBI patients. Different ONSD cut-off values need not be age- or sex-adjusted for the assessment of increased ICP in TBI patients.
- Published
- 2020
- Full Text
- View/download PDF
131. Neurosurgical randomized trials in low- and middle-income countries
- Author
-
Karol P. Budohoski, Angelos G. Kolias, Andres M. Rubiano, Kee B. Park, Tiffany E. Chao, Marike L. D. Broekman, Franco Servadei, Gerald A. Grant, Rikin A. Trivedi, Peter J. Hutchinson, Ahsan A. Khan, B Indira Devi, Walter D. Johnson, Dylan Griswold, David Clark, Tej D. Azad, and Rubiano, Andrés M. [0000-0001-8931-3254]
- Subjects
Male ,AcademicSubjects/MED00930 ,Neuros/3 ,Neurosurgery ,Global health ,Global neurosurgery ,Access to care ,Review ,Neurosurgical Procedures ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,030212 general & internal medicine ,Developing Countries ,Randomized Controlled Trials as Topic ,Low- and middle-income countries ,business.industry ,Research ,Low-and middle-income countries ,Spinal surgery ,Global surgery ,Research capacity strengthening ,Bibliometrics ,Low and middle income countries ,Female ,Surgery ,Neurology (clinical) ,Health disparities ,business ,Humanities ,Neurotrauma ,030217 neurology & neurosurgery - Abstract
ANTECEDENTES: El contexto de un ensayo aleatorio puede determinar si sus hallazgos son generalizables y, por lo tanto, pueden aplicarse a diferentes entornos. La contribucion de los paises de ingresos bajos y medianos (PIBM) a los ensayos aleatorizados de neurocirugia no se ha descrito sistematicamente antes. OBJETIVO: Realizar un analisis sistematico de las caracteristicas del diseno y la metodologia, la fuente de financiacion y las intervenciones estudiadas entre los ensayos dirigidos y / o realizados en paises de altos ingresos (HIC) frente a LMIC. METODOS: Desde enero de 2003 hasta julio de 2016, los ensayos en ingles con> 5 pacientes que evaluaban cualquier procedimiento neuroquirurgico frente a otro procedimiento, tratamiento no quirurgico o ningun tratamiento se recuperaron de MEDLINE, Scopus y Cochrane Library. La clasificacion de ingresos de cada pais se evaluo mediante el metodo Atlas del Banco Mundial. RESULTADOS: Un total de 73,3% de los 397 estudios que cumplieron con los criterios de inclusion fueron dirigidos por paises de ingresos bajos, mientras que el 26,7% fueron dirigidos por paises de ingresos bajos y medianos. Si se excluye a China, solo el 8,8% fueron liderados por paises de ingresos bajos y medianos. Los ensayos dirigidos por HIC inscribieron una mediana de 92 pacientes frente a una mediana de 65 pacientes en los ensayos dirigidos por LMIC. Ensayos dirigidos por HIC inscritos en 7,6 sitios frente a 1,8 sitios en estudios dirigidos por LMIC. Mas de la mitad de los ensayos dirigidos por LMIC fueron financiados institucionalmente (54,7%). La mayoria de los ensayos dirigidos por HIC y LMIC evaluaron la neurocirugia espinal, 68% y 71,7%, respectivamente. CONCLUSION: Hemos establecido que existe una disparidad sustancial entre los HIC y los LMIC en el numero de ensayos neuroquirurgicos publicados. Un esfuerzo concertado para invertir en el desarrollo de la capacidad de investigacion en los PIBM es un paso esencial para garantizar que se generen pruebas de alta calidad especificas del contexto y de los recursos.
- Published
- 2020
132. Lung Injury Is a Predictor of Cerebral Hypoxia and Mortality in Traumatic Brain Injury
- Author
-
Chiara Robba, Shadnaz Asgari, Amit Gupta, Rafael Badenes, Mypinder Sekhon, Erta Bequiri, Peter J. Hutchinson, Paolo Pelosi, Arun Gupta, Hutchinson, Peter [0000-0002-2796-1835], and Apollo - University of Cambridge Repository
- Subjects
medicine.medical_specialty ,Traumatic brain injury ,Lung injury ,lcsh:RC346-429 ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Fraction of inspired oxygen ,medicine ,cerebral oxygenation ,Cerebral perfusion pressure ,lung injury ,lcsh:Neurology. Diseases of the nervous system ,Intracranial pressure ,Original Research ,partial arterial oxygen pressure ,business.industry ,hypoxia threshold ,mortality outcome ,traumatic brain injury ,Cerebral hypoxia ,Neurointensive care ,030208 emergency & critical care medicine ,respiratory system ,medicine.disease ,Oxygen tension ,respiratory tract diseases ,Neurology ,Cardiology ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,circulatory and respiratory physiology - Abstract
Background: A major contributor to unfavorable outcome after traumatic brain injury (TBI) is secondary brain injury. Low brain tissue oxygen tension (PbtO2) has shown to be an independent predictor of unfavorable outcome. Although PbtO2 provides clinicians with an understanding of the ischemic and non-ischemic derangements of brain physiology, its value does not take into consideration systemic oxygenation that can influence patients' outcomes. This study analyses brain and systemic oxygenation and a number of related indices in TBI patients: PbtO2, partial arterial oxygenation pressure (PaO2), PbtO2/PaO2, ratio of PbtO2 to fraction of inspired oxygen (FiO2), and PaO2/FiO2. The primary aim of this study was to identify independent risk factors for cerebral hypoxia. Secondary goal was to determine whether any of these indices are predictors of mortality outcome in TBI patients. Materials and Methods: A single-centre retrospective cohort study of 70 TBI patients admitted to the Neurocritical Care Unit (NCCU) at Cambridge University Hospital in 2014-2018 and undergoing advanced neuromonitoring including invasive PbtO2 was conducted. Three hundred and three simultaneous measurements of PbtO2, PaO2, PbtO2/PaO2, PbtO2/FiO2, PaO2/FiO2 were collected and mortality at discharge from NCCU was considered as outcome. Generalized estimating equations were used to analyse the longitudinal data. Results: Our results showed PbtO2 of 28 mmHg as threshold to define cerebral hypoxia. PaO2/FiO2 found to be a strong and independent risk factor for cerebral hypoxia when adjusting for confounding factor of intracranial pressure (ICP) with adjusted odds ratio of 1.78, 95% confidence interval of (1.10-2.87) and p-value = 0.019. With respect to TBI outcome, compromised values of PbtO2, PbtO2/PaO2, PbtO2/FiO2, and PaO2/FiO2 were all independent predictors of mortality while considered individually and adjusting for confounding factors of ICP, age, gender, and cerebral perfusion pressure (CPP). However, when considering all the compromised values together, only PaO2/FiO2 became an independent predictor of mortality with adjusted odds ratio of 3.47 (1.20-10.04) and p-value = 0.022. Conclusions: Brain and Lung interaction in TBI patients is a complex interrelationship. PaO2/FiO2 seems to be a major determinant of cerebral hypoxia and mortality. These results confirm the importance of employing ventilator strategies to prevent cerebral hypoxia and improve the outcome in TBI patients.
- Published
- 2020
133. Alterations in Microstructure and Local Fiber Orientation of White Matter Are Associated with Outcome after Mild Traumatic Brain Injury
- Author
-
David K. Menon, Mehrbod Mohammadian, Timo Kurki, Riikka S.K. Takala, Timo Roine, Peter J. Hutchinson, Henna Riikka Maanpää, Virginia F. J. Newcombe, Jussi Hirvonen, Jussi P. Posti, Jussi Tallus, Olli Tenovuo, Janek Frantzén, Ari Katila, Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, and Aalto University
- Subjects
Adult ,Male ,Adolescent ,Traumatic brain injury ,Fiber orientation ,computer.software_genre ,White matter ,Young Adult ,Voxel ,mild traumatic brain injury ,Fractional anisotropy ,medicine ,Humans ,Brain Concussion ,Aged ,Aged, 80 and over ,Chronic stage ,medicine.diagnostic_test ,business.industry ,ABNORMALITIES ,Brain ,Magnetic resonance imaging ,SPATIAL STATISTICS ,Recovery of Function ,Middle Aged ,medicine.disease ,diffusion tensor imaging ,WATER DIFFUSION ,White Matter ,CORPUS-CALLOSUM ,DIFFUSE AXONAL INJURY ,CONSTRAINED SPHERICAL DECONVOLUTION ,medicine.anatomical_structure ,DYSMYELINATION ,Diffusion Tensor Imaging ,DTI ,tract-based spatial statistics ,outcome ,Female ,Neurology (clinical) ,business ,Nuclear medicine ,TENSOR IMAGING DETECTS ,computer ,Diffusion MRI ,MRI - Abstract
Mild traumatic brain injury (mTBI) can have long-lasting consequences. We investigated white matter (WM) alterations at 6-12 months following mTBI using diffusion tensor imaging (DTI) and assessed if the alterations associate with outcome. Eighty-five patients with mTBI underwent diffusion-weighted magnetic resonance imaging (MRI) on average 8 months post-injury and patients' outcome was assessed at the time of imaging using the Glasgow Outcome Scale-Extended (GOS-E). Additionally, 30 age-matched patients with extracranial orthopedic injuries were used as control subjects. Voxel-wise analysis of the data was performed using a tract-based spatial statistics (TBSS) approach and differences in microstructural metrics between groups were investigated. Further, the susceptibility of the abnormalities to specific fiber orientations was investigated by analyzing the first eigenvector of the diffusion tensor in the voxels with significant differences. We found significantly lower fractional anisotropy (FA) and highermean diffusivity (MD) and radial diffusivity (RD) in patients with mTBI compared with control subjects, whereas no significant differences were observed in axial diffusivity (AD) between the groups. The differences were present bilaterally in several WM regions and correlated with outcome. Moreover, multiple clusters were found in the principal fiber orientations of the significant voxels in anisotropy, and similar orientation patterns were found for the diffusivity metrics. These directional clusters correlated with patients' functional outcome. Our study showed that mTBI is associated with WM changes at the chronic stage and these alterations occur in several WM regions. In addition, several significant clusters of WM alterations in specific fiber orientations were found and these clusters were associated with outcome.
- Published
- 2020
134. Identification of factors associated with morbidity and postoperative length of stay in surgically managed chronic subdural haematoma using electronic health records: a retrospective cohort study
- Author
-
Rowan M Burnstein, Benjamin Davies, Ari Ercole, Tom Bashford, Alexis J Joannides, Peter J. Hutchinson, Daniel J. Stubbs, David K. Menon, Stubbs, Daniel J [0000-0003-2778-5226], Davies, Benjamin M [0000-0003-0591-5069], Bashford, Tom [0000-0003-0228-9779], Menon, David K [0000-0002-3228-9692], Ercole, Ari [0000-0001-8350-8093], and Apollo - University of Cambridge Repository
- Subjects
Adult ,Male ,medicine.medical_specialty ,statistics & research methods ,lcsh:Medicine ,quality in health care ,Anaesthesia ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Sex Factors ,Epidemiology ,Medicine ,Electronic Health Records ,Humans ,General anaesthesia ,030212 general & internal medicine ,neurosurgery ,Retrospective Studies ,business.industry ,lcsh:R ,Retrospective cohort study ,General Medicine ,Length of Stay ,medicine.disease ,Comorbidity ,3. Good health ,Surgery ,anaesthetics ,Hematoma, Subdural, Chronic ,Cohort ,epidemiology ,Female ,Neurosurgery ,Morbidity ,business ,Complication ,030217 neurology & neurosurgery ,Cohort study - Abstract
IntroductionChronic subdural haematoma (cSDH) tends to occur in older patients, often with significant comorbidity. The incidence and effect of medical complications as well as the impact of intraoperative management strategies are now attracting increasing interest.ObjectivesWe used electronic health record data to study the profile of in-hospital morbidity and examine associations between various intraoperative events and postoperative stay.Design, setting and participantsSingle-centre, retrospective cohort of 530 cases of cSDH (2014–2019) surgically evacuated under general anaesthesia at a neurosciences centre in Cambridge, UK.Methods and outcome definitionComplications were defined using a modified Electronic Postoperative Morbidity Score. Association between complications and intraoperative care (time with mean arterial pressure 2) range of 3–5 kPa, maintenance anaesthetic, operative time and opioid dose) on postoperative stay was assessed using Cox regression.Results53 (10%) patients suffered myocardial injury, while 24 (4.5%) suffered acute renal injury. On postoperative day 3 (D3), 280 (58% of remaining) inpatients suffered at least 1 complication. D7 rate was comparable (57%). Operative time was the only intraoperative event associated with postoperative stay (HR for discharge: 0.97 (95% CI: 0.95 to 0.99)). On multivariable analysis, postoperative complications (0.61 (0.55 to 0.68)), anticoagulation (0.45 (0.37 to 0.54)) and cognitive impairment (0.71 (0.58 to 0.87)) were associated with time to discharge.ConclusionsThere is a high postoperative morbidity burden in this cohort, which was associated with postoperative stay. We found no evidence of an association between intraoperative events and postoperative stay.
- Published
- 2020
135. Assessment of cerebral autoregulation indices – a modelling perspective
- Author
-
Xiuyun Liu, Manuel Cabeleira, Joseph Donnelly, Danilo Cardim, Despina Aphroditi Lalou, Peter J. Hutchinson, Xiao Hu, Marek Czosnyka, Peter Smielewski, Donnelly, Joseph [0000-0002-6502-8069], Lalou, Despina Aphroditi [0000-0003-3768-8681], Smielewski, Peter [0000-0001-5096-3938], and Apollo - University of Cambridge Repository
- Subjects
Adult ,Male ,medicine.medical_specialty ,Correlation coefficient ,Models, Neurological ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Cerebral autoregulation ,Article ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Brain Injuries, Traumatic ,Dynamical systems ,medicine ,Homeostasis ,Humans ,Autoregulation ,Very low frequency ,lcsh:Science ,692/308/1426 ,Cerebrum ,Mathematics ,Multidisciplinary ,692/617 ,lcsh:R ,Confounding ,119/118 ,Experimental models of disease ,631/378/116/2393 ,Noise ,Neurology ,Cerebral blood flow ,Colors of noise ,Cerebrovascular Circulation ,Cardiology ,lcsh:Q ,Female ,030217 neurology & neurosurgery - Abstract
Various methodologies to assess cerebral autoregulation (CA) have been developed, including model - based methods (e.g. autoregulation index, ARI), correlation coefficient - based methods (e.g. mean flow index, Mx), and frequency domain - based methods (e.g. transfer function analysis, TF). Our understanding of relationships among CA indices remains limited, partly due to disagreement of different studies by using real physiological signals, which introduce confounding factors. The influence of exogenous noise on CA parameters needs further investigation. Using a set of artificial cerebral blood flow velocities (CBFV) generated from a well-known CA model, this study aims to cross-validate the relationship among CA indices in a more controlled environment. Real arterial blood pressure (ABP) measurements from 34 traumatic brain injury patients were applied to create artificial CBFVs. Each ABP recording was used to create 10 CBFVs corresponding to 10 CA levels (ARI from 0 to 9). Mx, TF phase, gain and coherence in low frequency (LF) and very low frequency (VLF) were calculated. The influence of exogenous noise was investigated by adding three levels of colored noise to the artificial CBFVs. The result showed a significant negative relationship between Mx and ARI (r = −0.95, p
- Published
- 2020
136. Relationship between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute Traumatic Brain Injury Patients: A CENTER-TBI Study
- Author
-
Ari Ercole, Virginia F. J. Newcombe, Frederick A. Zeiler, Peter J. Hutchinson, Marek Czosnyka, David K. Menon, Investigators, Peter Smielewski, Miguel Monteiro, Konstantinos Kamnitsas, Francois Mathieu, Ben Glocker, Tilak Das, Daniel P. Whitehouse, Mathieu, F, Zeiler, F, Ercole, A, Monteiro, M, Kamnitsas, K, Glocker, B, Whitehouse, D, Das, T, Smielewski, P, Czosnyka, M, Hutchinson, P, Newcombe, V, Menon, D, and Citerio, G
- Subjects
Adult ,Male ,030506 rehabilitation ,medicine.medical_specialty ,Traumatic brain injury ,Cerebral autoregulation ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Cerebrovascular reactivity ,Internal medicine ,Edema ,Brain Injuries, Traumatic ,Medicine ,Humans ,Cerebral perfusion pressure ,Intraparenchymal hemorrhage ,Intersectoral Collaboration ,cerebral autoregulation, intracranial hemorrhage, traumatic brain injury ,business.industry ,Original Articles ,Middle Aged ,medicine.disease ,Europe ,Intensive Care Units ,Treatment Outcome ,Brain Injuries ,Cerebrovascular Circulation ,Cohort ,Cardiology ,Disease Progression ,Intracranial lesions ,Female ,Neurology (clinical) ,medicine.symptom ,0305 other medical science ,business ,Tomography, X-Ray Computed ,030217 neurology & neurosurgery - Abstract
Failure of cerebral autoregulation has been linked to unfavorable outcome after traumatic brain injury (TBI). Preliminary evidence from a small, retrospective, single-center analysis suggests that autoregulatory dysfunction may be associated with traumatic lesion expansion, particularly for pericontusional edema. The goal of this study was to further explore these associations using prospective, multi-center data from the Collaborative European Neurotrauma Effectiveness Research in TBI (CENTER-TBI) and to further explore the relationship between autoregulatory failure, lesion progression, and patient outcome. A total of 88 subjects from the CENTER-TBI High Resolution ICU Sub-Study cohort were included. All patients had an admission computed tomography (CT) scan and early repeat scan available, as well as high-frequency neurophysiological recordings covering the between-scan interval. Using a novel, semiautomated approach at lesion segmentation, we calculated absolute changes in volume of contusion core, pericontusional edema, and extra-axial hemorrhage between the imaging studies. We then evaluated associations between cerebrovascular reactivity metrics and radiological lesion progression using mixed-model regression. Analyses were adjusted for baseline covariates and non-neurophysiological factors associated with lesion growth using multi-variate methods. Impairment in cerebrovascular reactivity was significantly associated with progression of pericontusional edema and, to a lesser degree, intraparenchymal hemorrhage. In contrast, there were no significant associations with extra-axial hemorrhage. The strongest relationships were observed between RAC-based metrics and edema formation. Pulse amplitude index showed weaker, but consistent, associations with contusion growth. Cerebrovascular reactivity metrics remained strongly associated with lesion progression after taking into account contributions from non-neurophysiological factors and mean cerebral perfusion pressure. Total hemorrhagic core and edema volumes on repeat CT were significantly larger in patients who were deceased at 6 months, and the amount of edema was greater in patients with an unfavourable outcome (Glasgow Outcome Scale-Extended 1-4). Our study suggests associations between autoregulatory failure, traumatic edema progression, and poor outcome. This is in keeping with findings from a single-center retrospective analysis, providing multi-center prospective data to support those results.
- Published
- 2020
137. Drains result in greater reduction of subdural width and midline shift in burr hole evacuation of chronic subdural haematoma
- Author
-
Paul Brennan, Angelos G. Kolias, Peter J. Hutchinson, Michael T C Poon, Laurence J Glancz, and Apollo - University of Cambridge Repository
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Subgroup analysis ,Subdural Space ,Outcomes ,Midline shift ,Chronic subdural haematoma ,Burr hole evacuation ,Postoperative Complications ,Brain trauma ,Original Article - Brain Trauma ,Trephining ,medicine ,Humans ,Prospective cohort study ,Reduction (orthopedic surgery) ,Aged ,Neuroradiology ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Interventional radiology ,Middle Aged ,Surgery ,Drains ,Hematoma, Subdural, Chronic ,Drainage ,Female ,Neurology (clinical) ,Neurosurgery ,business ,Radiology - Abstract
Funder: University of Edinburgh, Background: Drain insertion following chronic subdural haematoma (CSDH) evacuation reduces recurrence and improves outcomes. The mechanism of this improvement is uncertain. We assessed whether drains result in improved postoperative imaging, and which radiological factors are associated with recurrence and functional outcome. Methods: A multi-centre, prospective cohort study of CSDH patients was performed between May 2013 and January 2014. Patients aged > 16 years undergoing burr hole evacuation of primary CSDH with pre- and postoperative imaging were included in this subgroup analysis. Baseline and clinical details were collected. Pre- and postoperative maximal subdural width and midline shift (MLS) along with clot density were recorded. Primary outcomes comprised mRS at discharge and symptomatic recurrence requiring re-drainage. Comparisons were made using multiple logistic regression. Results: Three hundred nineteen patients were identified for inclusion. Two hundred seventy-two of 319 (85%) patients underwent drain insertion at the time of surgery versus 45/319 (14%) who did not. Twenty-nine of 272 patients who underwent drain insertion experienced recurrence (10.9%) versus 9 of 45 patients without drain insertion (20.5%; p = 0.07). Overall change in median subdural width was significantly greater in the drain versus ‘no drain’ groups (11 mm versus 6 mm, p < 0.01). Overall change in median midline shift (MLS) was also significantly greater in the drain group (4 mm versus 3 mm, p < 0.01). On multivariate analysis, change in maximal width and MLS were significant predictors of recurrence, although only the former remained a significant predictor for functional outcome. Conclusions: The use of subdural drains results in significantly improved postoperative imaging in burr hole evacuation of CSDH, thus providing radiological corroboration for their recommended use.
- Published
- 2020
- Full Text
- View/download PDF
138. Admission Levels of Total Tau and β-Amyloid Isoforms 1–40 and 1–42 in Predicting the Outcome of Mild Traumatic Brain Injury
- Author
-
Iftakher Hossain, Mehrbod Mohammadian, Riikka S. K. Takala, Olli Tenovuo, Leire Azurmendi Gil, Janek Frantzén, Mark van Gils, Peter J. Hutchinson, Ari J. Katila, Henna-Riikka Maanpää, David K. Menon, Virginia F. Newcombe, Jussi Tallus, Kevin Hrusovsky, David H. Wilson, Jessica Gill, Kaj Blennow, Jean-Charles Sanchez, Henrik Zetterberg, Jussi P. Posti, Apollo - University of Cambridge Repository, Hutchinson, Peter [0000-0002-2796-1835], and Newcombe, Virginia [0000-0001-6044-9035]
- Subjects
medicine.medical_specialty ,Traumatic brain injury ,lcsh:RC346-429 ,total tau ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,lcsh:Neurology. Diseases of the nervous system ,030304 developmental biology ,Original Research ,0303 health sciences ,Receiver operating characteristic ,business.industry ,Glasgow Outcome Scale ,traumatic brain injury ,Glasgow Coma Scale ,Rivermead post-concussion symptoms questionnaire ,medicine.disease ,β-amyloid 1-40 ,β-amyloid 1-42 ,Neurology ,outcome ,Injury Severity Score ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Cohort study ,Blood sampling - Abstract
Background: The purpose of this study was to investigate if admission levels of total tau (T-tau) and β-amyloid isoforms 1-40 (Aβ40) and 1-42 (Aβ42) could predict clinical outcome in patients with mild traumatic brain injury (mTBI). Methods: A total of 105 patients with mTBI [Glasgow Coma Scale (GCS) ≥ 13] recruited in Turku University Hospital, Turku, Finland were included in this study. Blood samples were drawn within 24 h of admission for analysis of plasma T-tau, Aβ40, and Aβ42. Patients were divided into computed tomography (CT)-positive and CT-negative groups. The outcome was assessed 6–12 months after the injury using the Extended Glasgow Outcome Scale (GOSE). Outcomes were defined as complete (GOSE 8) or incomplete (GOSE < 8) recovery. The Rivermead Post Concussion Symptoms Questionnaire (RPCSQ) was also used to assess mTBI-related symptoms. Predictive values of the biomarkers were analyzed independently, in panels and together with clinical parameters. Results: The admission levels of plasma T-tau, Aβ40, and Aβ42 were not significantly different between patients with complete and incomplete recovery. The levels of T-tau, Aβ40, and Aβ42 could poorly predict complete recovery, with areas under the receiver operating characteristic curve 0.56, 0.52, and 0.54, respectively. For the whole cohort, there was a significant negative correlation between the levels of T-tau and ordinal GOSE score (Spearman ρ = −0.231, p = 0.018). In a multivariate logistic regression model including age, GCS, duration of posttraumatic amnesia, Injury Severity Score (ISS), time from injury to sampling, and CT findings, none of the biomarkers could predict complete recovery independently or together with the other two biomarkers. Plasma levels of T-tau, Aβ40, and Aβ42 did not significantly differ between the outcome groups either within the CT-positive or CT-negative subgroups. Levels of Aβ40 and Aβ42 did not significantly correlate with outcome, but in the CT-positive subgroup, the levels of T-tau significantly correlated with ordinal GOSE score (Spearman ρ = −0.288, p = 0.035). The levels of T-tau, Aβ40, and Aβ42 were not correlated with the RPCSQ scores. Conclusions: The early levels of T-tau are correlated with the outcome in patients with mTBI, but none of the biomarkers either alone or in any combinations could predict complete recovery in patients with mTBI. © Copyright © 2020 Hossain, Mohammadian, Takala, Tenovuo, Azurmendi Gil, Frantzen, van Gils, Hutchinson, Katila, Maanpaa, Menon, Newcombe, Tallus, Hrusovsky, Wilson, Gill, Blennow, Sanchez, Zetterberg and Posti.
- Published
- 2020
139. Multimodality Monitoring in Head Injury
- Author
-
Tamara Tajsic, Andrew Gvozdanovic, Ivan Timofeev, and Peter J. Hutchinson
- Published
- 2020
140. Medicolegal Aspects of Traumatic Brain and Cervical Spine Injury
- Author
-
Peter C. Whitfield and Peter J. Hutchinson
- Subjects
medicine.medical_specialty ,business.industry ,medicine ,Medicolegal aspects ,Cervical spine injury ,business ,Surgery - Published
- 2020
141. Intracranial Pressure Monitoring in Head Injury
- Author
-
Adam J. Wells, Peter Smielewski, Rikin A. Trivedi, and Peter J. Hutchinson
- Published
- 2020
142. A management algorithm for adult patients with both brain oxygen and intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC)
- Author
-
Gregory W.J. Hawryluk, Andres M. Rubiano, Michael N. Diringer, Geoffrey T. Manley, David K. Menon, Juan Sahuquillo, Eve C. Tsai, Franco Servadei, Odette A. Harris, Ramon Diaz Arrastia, Alan Hoffer, Fabio Silvio Taccone, Romer Geocadin, Nino Stocchetti, Geert Meyfroidt, Sergio Aguilera, Lori Shutter, Jeffrey V. Rosenfeld, Stephan A. Mayer, Guoyi Gao, D. Jamie Cooper, David W. Wright, Peter J. Hutchinson, Deborah M. Stein, Ryan S. Kitagawa, Giuseppe Citerio, Jamshid Ghajar, Daniel B. Michael, Claudia S. Robertson, David O. Okonkwo, Paul M. Vespa, Shelly D. Timmons, Eileen M. Bulger, Mathew Joseph, Mauro Oddo, Jamie S. Ullman, Anthony Figaji, Randall M. Chesnut, Christopher Zammit, Andras Buki, Mayur B. Patel, Walter Videtta, Chesnut, R, Aguilera, S, Buki, A, Bulger, E, Citerio, G, Cooper, D, Arrastia, R, Diringer, M, Figaji, A, Gao, G, Geocadin, R, Ghajar, J, Harris, O, Hoffer, A, Hutchinson, P, Joseph, M, Kitagawa, R, Manley, G, Mayer, S, Menon, D, Meyfroidt, G, Michael, D, Oddo, M, Okonkwo, D, Patel, M, Robertson, C, Rosenfeld, J, Rubiano, A, Sahuquillo, J, Servadei, F, Shutter, L, Stein, D, Stocchetti, N, Taccone, F, Timmons, S, Tsai, E, Ullman, J, Vespa, P, Videtta, W, Wright, D, Zammit, C, and Hawryluk, G
- Subjects
Traumatic ,Intracranial Pressure ,Conference Reports and Expert Panel ,Critical Care and Intensive Care Medicine ,0302 clinical medicine ,Brain Injuries, Traumatic ,Protocol ,Brain injury ,Adult ,Algorithms ,Brain ,Brain Injuries, Traumatic/therapy ,Humans ,Intracranial Hypertension/therapy ,Monitoring, Physiologic ,Oxygen ,Algorithm ,Brain oxygen ,Consensus ,Head trauma ,Intracranial pressure ,PbtO2 ,SIBICC ,Seattle ,Tiers ,Consensus conference ,Management algorithm ,Public Health and Health Services ,Intracranial pressure monitoring ,medicine.medical_specialty ,Physical Injury - Accidents and Adverse Effects ,Monitoring ,Traumatic brain injury ,Clinical Sciences ,Consensu ,Traumatic Brain Injury (TBI) ,03 medical and health sciences ,Anesthesiology ,medicine ,Physiologic ,Intensive care medicine ,bt ,Traumatic Head and Spine Injury ,Protocol (science) ,Adult patients ,business.industry ,Neurosciences ,030208 emergency & critical care medicine ,medicine.disease ,Emergency & Critical Care Medicine ,Brain Disorders ,Tier ,030228 respiratory system ,Brain Injuries ,Intracranial Hypertension ,business - Abstract
Background Current guidelines for the treatment of adult severe traumatic brain injury (sTBI) consist of high-quality evidence reports, but they are no longer accompanied by management protocols, as these require expert opinion to bridge the gap between published evidence and patient care. We aimed to establish a modern sTBI protocol for adult patients with both intracranial pressure (ICP) and brain oxygen monitors in place. Methods Our consensus working group consisted of 42 experienced and actively practicing sTBI opinion leaders from six continents. Having previously established a protocol for the treatment of patients with ICP monitoring alone, we addressed patients who have a brain oxygen monitor in addition to an ICP monitor. The management protocols were developed through a Delphi-method-based consensus approach and were finalized at an in-person meeting. Results We established three distinct treatment protocols, each with three tiers whereby higher tiers involve therapies with higher risk. One protocol addresses the management of ICP elevation when brain oxygenation is normal. A second addresses management of brain hypoxia with normal ICP. The third protocol addresses the situation when both intracranial hypertension and brain hypoxia are present. The panel considered issues pertaining to blood transfusion and ventilator management when designing the different algorithms. Conclusions These protocols are intended to assist clinicians in the management of patients with both ICP and brain oxygen monitors but they do not reflect either a standard-of-care or a substitute for thoughtful individualized management. These protocols should be used in conjunction with recommendations for basic care, management of critical neuroworsening and weaning treatment recently published in conjunction with the Seattle International Brain Injury Consensus Conference. Electronic supplementary material The online version of this article (10.1007/s00134-019-05900-x) contains supplementary material, which is available to authorized users.
- Published
- 2020
143. Interleukin 10 and Heart Fatty Acid-Binding Protein as Early Outcome Predictors in Patients With Traumatic Brain Injury
- Author
-
Linnéa Lagerstedt, Leire Azurmendi, Olli Tenovuo, Ari J. Katila, Riikka S. K. Takala, Kaj Blennow, Virginia F. J. Newcombe, Henna-Riikka Maanpää, Jussi Tallus, Iftakher Hossain, Mark van Gils, David K. Menon, Peter J. Hutchinson, Henrik Zetterberg, Jussi P. Posti, Jean-Charles Sanchez, Newcombe, Virginia [0000-0001-6044-9035], Menon, David [0000-0002-3228-9692], Hutchinson, Peter [0000-0002-2796-1835], and Apollo - University of Cambridge Repository
- Subjects
medicine.medical_specialty ,Traumatic brain injury ,Gastroenterology ,lcsh:RC346-429 ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,In patient ,panel ,lcsh:Neurology. Diseases of the nervous system ,Original Research ,Glial fibrillary acidic protein ,biology ,business.industry ,Glasgow Outcome Scale ,traumatic brain injury ,030208 emergency & critical care medicine ,medicine.disease ,Predictive value ,heart fatty-acid binding protein ,Interleukin 10 ,nervous system ,Neurology ,Heart-type fatty acid binding protein ,biology.protein ,outcome ,Biomarker (medicine) ,biomarker ,Neurology (clinical) ,interleukin 10 ,business ,protein ,030217 neurology & neurosurgery - Abstract
Background: Patients with traumatic brain injury (TBI) exhibit a variable and unpredictable outcome. The proteins interleukin 10 (IL-10) and heart fatty acid-binding protein (H-FABP) have shown predictive values for the presence of intracranial lesions. Aim: To evaluate the individual and combined outcome prediction ability of IL-10 and H-FABP, and to compare them to the more studied proteins S100β, glial fibrillary acidic protein (GFAP), and neurofilament light (NF-L), both with and without clinical predictors. Methods: Blood samples from patients with acute TBI (all severities) were collected 6 months post injury using the Glasgow Outcome Scale Extended (GOSE) score, dichotomizing patients into: (i) those with favorable (GOSE≥5)/unfavorable outcome (GOSE ≤ 4) and complete (GOSE = 8)/incomplete (GOSE ≤ 7) recovery, and (ii) patients with mild TBI (mTBI) and patients with TBIs of all severities. Results: When sensitivity was set at 95–100%, the proteins' individual specificities remained low. H-FABP showed the best specificity (%) and sensitivity (100%) in predicting complete recovery in patients with mTBI. IL-10 had the best specificity (50%) and sensitivity (96%) in identifying patients with favorable outcome in patients with TBIs of all severities. When individual proteins were combined with clinical parameters, a model including H-FABP, NF-L, and ISS yielded a specificity of 56% and a sensitivity of 96% in predicting complete recovery in patients with mTBI. In predicting favorable outcome, a model consisting IL-10, age, and TBI severity reached a specificity of 80% and a sensitivity of 96% in patients with TBIs of all severities. Conclusion: Combining novel TBI biomarkers H-FABP and IL-10 with GFAP, NF-L and S100β and clinical parameters improves outcome prediction models in TBI.
- Published
- 2020
- Full Text
- View/download PDF
144. Brain Tissue Oxygen and Cerebrovascular Reactivity in Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Exploratory Analysis of Insult Burden
- Author
-
David K. Menon, Investigators, Frederick A. Zeiler, Nino Stocchetti, Ari Ercole, Erta Beqiri, Peter J. Hutchinson, Marek Czosnyka, Manuel Cabeleira, and Peter Smielewski
- Subjects
Adult ,Male ,030506 rehabilitation ,medicine.medical_specialty ,Biomedical Research ,Traumatic brain injury ,media_common.quotation_subject ,Glasgow Outcome Scale ,Brain tissue ,Insult ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Cerebrovascular reactivity ,Oxygen Consumption ,Cost of Illness ,Internal medicine ,Brain Injuries, Traumatic ,medicine ,Humans ,Autoregulation ,Prospective Studies ,Intersectoral Collaboration ,media_common ,Aged ,business.industry ,Brain ,Exploratory analysis ,Original Articles ,Middle Aged ,medicine.disease ,Pressure reactivity ,Europe ,Treatment Outcome ,Cerebrovascular Circulation ,Cardiology ,Female ,Neurology (clinical) ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Pressure reactivity index (PRx) and brain tissue oxygen (PbtO(2)) are associated with outcome in traumatic brain injury (TBI). This study explores the relationship between PRx and PbtO(2) in adult moderate/severe TBI. Using the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) high resolution intensive care unit (ICU) sub-study cohort, we evaluated those patients with archived high-frequency digital intraparenchymal intracranial pressure (ICP) and PbtO(2) monitoring data of, a minimum of 6 h in duration, and the presence of a 6 month Glasgow Outcome Scale –Extended (GOSE) score. Digital physiological signals were processed for ICP, PbtO(2), and PRx, with the % time above/below defined thresholds determined. The duration of ICP, PbtO(2), and PRx derangements was characterized. Associations with dichotomized 6-month GOSE (alive/dead, and favorable/unfavorable outcome; ≤ 4 = unfavorable), were assessed. A total of 43 patients were included. Severely impaired cerebrovascular reactivity was seen during elevated ICP and low PbtO(2) episodes. However, most of the acute ICU physiological derangements were impaired cerebrovascular reactivity, not ICP elevations or low PbtO(2) episodes. Low PbtO(2) without PRx impairment was rarely seen. % time spent above PRx threshold was associated with mortality at 6 months for thresholds of 0 (area under the curve [AUC] 0.734, p = 0.003), > +0.25 (AUC 0.747, p = 0.002) and > +0.35 (AUC 0.745, p = 0.002). Similar relationships were not seen for % time with ICP >20 mm Hg, and PbtO(2) < 20 mm Hg in this cohort. Extreme impairment in cerebrovascular reactivity is seen during concurrent episodes of elevated ICP and low PbtO(2). However, the majority of the deranged cerebral physiology seen during the acute ICU phase is impairment in cerebrovascular reactivity, with most impairment occurring in the presence of normal PbtO(2) levels. Measures of cerebrovascular reactivity appear to display the most consistent associations with global outcome in TBI, compared with ICP and PbtO(2).
- Published
- 2020
145. Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly
- Author
-
Angelos G. Kolias, Virginia Levrini, Matthew R. Garnett, Zofia Czosnyka, Peter J. Hutchinson, Afroditi D Lalou, Laurent Gergelé, Marek Czosnyka, Apollo - University of Cambridge Repository, Lalou, Despoina [0000-0003-3768-8681], Kolias, Angelos [0000-0003-3992-0587], and Hutchinson, Peter [0000-0002-2796-1835]
- Subjects
Adult ,Male ,medicine.medical_specialty ,Intracranial Pressure ,Traumatic brain injury ,Csf Infusion Test ,lcsh:RC346-429 ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Cerebrospinal fluid ,Atrophy ,Developmental Neuroscience ,Internal medicine ,Brain Injuries, Traumatic ,medicine ,Humans ,Encephalomalacia ,lcsh:Neurology. Diseases of the nervous system ,Intracranial pressure ,Aged ,Retrospective Studies ,business.industry ,Research ,General Medicine ,Middle Aged ,medicine.disease ,Hydrocephalus, Normal Pressure ,Hydrocephalus ,Shunting ,Neurology ,030220 oncology & carcinogenesis ,Ventriculomegaly ,Cardiology ,Hydrodynamics ,Csf Dynamics ,Female ,business ,030217 neurology & neurosurgery - Abstract
Background Post-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic tool. We aim to report CSF dynamics of patients with post-traumatic ventriculomegaly. Materials and methods We retrospectively analysed post-traumatic brain injury (TBI) patients with ventriculomegaly who had undergone a CSF infusion test. We calculated the resistance to CSF outflow (Rout), AMP (pulse amplitude of intracranial pressure, ICP), dAMP (AMPplateau-AMPbaseline) and compensatory reserve index correlation coefficient between ICP and AMP (RAP). To avoid confounding factors, included patients had to be non-decompressed or with cranioplasty > 1 month previously and Rout > 6 mmHg/min/ml. Compliance was assessed using the elasticity coefficient. We also compared infusion-tested TBI patients selected for shunting versus those not selected for shunting (consultant decision based on clinical and radiological assessment and the infusion results). Finally, we used data from a group of shunted idiopathic Normal Pressure Hydrocephalus (iNPH) patients for comparison. Results Group A consisted of 36 patients with post-traumatic ventriculomegaly and Group B of 45 iNPH shunt responders. AMP and dAMP were significantly lower in Group A than B (0.55 ± 0.39 vs 1.02 ± 0.72; p Conclusions Rout and AMP were significantly lower in PTH compared to iNPH and did not always reflect the degree of hydrocephalus or atrophy reported on CT/MRI. Compliance appears reduced in PTH.
- Published
- 2020
146. Statistical cerebrovascular reactivity signal properties after secondary decompressive craniectomy in traumatic brain injury
- Author
-
Marek Czosnyka, Marcel J.H. Aries, Ari Ercole, David K. Menon, Peter J. Hutchinson, Manuel Cabeleira, Frederick A. Zeiler, Ivan Timofeev, Peter Smieleweski, Thomas A. van Essen, Nino Stocchetti, Menon, David [0000-0002-3228-9692], Czosnyka, Marek [0000-0003-2446-8006], Smielewski, Peter [0000-0001-5096-3938], Hutchinson, Peter [0000-0002-2796-1835], Ercole, Ari [0000-0001-8350-8093], Apollo - University of Cambridge Repository, Intensive Care, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, and MUMC+: MA Medische Staf IC (9)
- Subjects
Adult ,Male ,musculoskeletal diseases ,030506 rehabilitation ,medicine.medical_specialty ,Neurology ,Adolescent ,Intracranial Pressure ,INTRACRANIAL-PRESSURE ,Traumatic brain injury ,medicine.medical_treatment ,INDEXES ,lower limit ,Pilot Projects ,part ii ,DC ,cerebrovascular reactivity ,Cohort Studies ,Young Adult ,03 medical and health sciences ,Vascular reactivity ,0302 clinical medicine ,Cerebrovascular reactivity ,Brain Injuries, Traumatic ,TBI ,MANAGEMENT ,medicine ,Humans ,Prospective Studies ,validation ,decompressive craniectomy ,business.industry ,autoregulation ,PRx ,Original Articles ,Middle Aged ,medicine.disease ,Intensive Care Units ,CEREBRAL PERFUSION-PRESSURE ,Cerebrovascular Circulation ,Anesthesia ,Female ,Decompressive craniectomy ,Neurology (clinical) ,Neurosurgery ,Tomography, X-Ray Computed ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Decompressive craniectomy (DC) in traumatic brain injury (TBI) has been suggested to influence cerebrovascular reactivity. We aimed to determine if the statistical properties of vascular reactivity metrics and slow-wave relationships were impacted after DC, as such information would allow us to comment on whether vascular reactivity monitoring remains reliable after craniectomy. Using the CENTER-TBI High Resolution Intensive Care Unit (ICU) Sub-Study cohort, we selected those secondary DC patients with high-frequency physiological data for both at least 24 h pre-DC, and more than 48 h post-DC. Data for all physiology measures were separated into the 24 h pre-DC, the first 48 h post-DC, and beyond 48 h post-DC. We produced slow-wave data sheets for intracranial pressure (ICP) and mean arterial pressure (MAP) per patient. We also derived a Pressure Reactivity Index (PRx) as a continuous cerebrovascular reactivity metric updated every minute. The time-series behavior of the PRx was modeled for each time period per patient. Finally, the relationship between ICP and MAP during these three time periods was assessed using time-series vector autoregressive integrative moving average (VARIMA) models, impulse response function (IRF) plots, and Granger causality testing. Ten patients were included in this study. Mean PRx and proportion of time above PRx thresholds were not affected by craniectomy. Similarly, PRx time-series structure was not affected by DC, when assessed in each individual patient. This was confirmed with Granger causality testing, and VARIMA IRF plotting for the MAP/ICP slow-wave relationship. PRx metrics and statistical time-series behavior appear not to be substantially influenced by DC. Similarly, there is little change in the relationship between slow waves of ICP and MAP before and after DC. This may suggest that cerebrovascular reactivity monitoring in the setting of DC may still provide valuable information regarding autoregulation.
- Published
- 2020
147. Cisternostomy for traumatic brain injury-rigorous evaluation is necessary
- Author
-
Ramez W. Kirollos, Angelos G. Kolias, Franco Servadei, Tariq Khan, and Peter J. Hutchinson
- Subjects
medicine.medical_specialty ,Neurology ,medicine.diagnostic_test ,Traumatic brain injury ,business.industry ,MEDLINE ,Interventional radiology ,medicine.disease ,medicine ,Surgery ,Neurology (clinical) ,Neurosurgery ,Intensive care medicine ,business ,Neuroradiology - Published
- 2020
148. Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural Trauma
- Author
-
Jamie S. Mitchell, Peter J. Hutchinson, Rickie Patani, Eric Peter Thelin, Susan Giorgi-Coll, Giulia E. Tyzack, Keri L. H. Carpenter, Adel Helmy, Arvid Frostell, Tamara Tajsic, Claire E. Hall, Aftab Alam, Thelin, Eric [0000-0002-2338-4364], Alam, Mohammed [0000-0001-8089-6721], Carpenter, Keri [0000-0001-8236-7727], Hutchinson, Peter [0000-0002-2796-1835], Helmy, Adel [0000-0002-0531-0556], and Apollo - University of Cambridge Repository
- Subjects
030506 rehabilitation ,human iPSC-derived astrocytes ,Traumatic brain injury ,medicine.medical_treatment ,Induced Pluripotent Stem Cells ,TNF ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Neural Stem Cells ,TBI ,Brain Injuries, Traumatic ,Medicine ,Humans ,Interleukin 6 ,Interleukin 4 ,Neuroinflammation ,Cells, Cultured ,IL-6 ,biology ,business.industry ,IL-4 ,in vitro ,Original Articles ,medicine.disease ,3. Good health ,cytokine exposure ,Interleukin 10 ,Cytokine ,IL-1β ,Astrocytes ,Immunology ,IL-10 ,biology.protein ,Cytokines ,Neurology (clinical) ,Stem cell ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Neuroinflammation has been shown to mediate the pathophysiological response following traumatic brain injury (TBI). Accumulating evidence implicates astrocytes as key immune cells within the central nervous system (CNS), displaying both pro- and anti-inflammatory properties. The aim of this study was to investigate how in vitro human astrocyte cultures respond to cytokines across a concentration range that approximates the aftermath of human TBI. To this end, enriched cultures of human induced pluripotent stem cell (iPSC)-derived astrocytes were exposed to interleukin-1β (IL-1β) (1–10,000 pg/mL), IL-4 (1–10,000 pg/mL), IL-6 (100–1,000,000 pg/mL), IL-10 (1–10,000 pg/mL) and tumor necrosis factor (TNF)-α (1–10,000 pg/mL). After 1, 24, 48 and 72 h, cultures were fixed and immunolabeled, and the secretome/supernatant was analyzed at 24, 48, and 72 h using a human cytokine/chemokine 39-plex Luminex assay. Data were compared to previous in vitro studies of neuronal cultures and clinical TBI studies. The secretome revealed concentration-, time- and/or both concentration- and time-dependent production of downstream cytokines (29, 21, and 17 cytokines, respectively, p
- Published
- 2020
149. Crosshole mapping of a subsurface void
- Author
-
Maggie H. Tsai and Peter J. Hutchinson
- Subjects
Void (astronomy) ,Mineralogy ,Geology - Published
- 2020
150. A Randomised Controlled Trial of Surgical Microdiscectomy Versus Trans-Foraminal Epidural Steroid Injection for Sciatica of Up to 1 Year; The NERVES Trial
- Author
-
Martin Wilby, Paula R Williamson, Cathy Price, Dianne Wheatley, Emma Bedson, Dyfrig A. Hughes, Hannah Short, Ganesan Baranidharan, Simon Clark, Daniel Hill-McManus, Eifiona Wood, Manohar Sharma, Peter J. Hutchinson, Richard J. Mannion, Anthony G Marson, A. Best, and Girvan Burnside
- Subjects
Sciatica ,medicine.medical_specialty ,Randomized controlled trial ,Epidural steroid injection ,law ,business.industry ,medicine.medical_treatment ,medicine ,medicine.symptom ,business ,Surgery ,law.invention - Published
- 2020
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.