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We reviewed the clinical and histopathologic findings in 25 Spitz's nevus who were evaluated at our institution from 1980-1988. 18 cases in patients aged 20 years or less and 7 cases in adults. 14 are female and 11 are male. Represent the 3.88% of melanocytic nevi etude in the same time. Eosinophilic globules were find in 64% of the cases. We include a pigmented spindle cell nevi (non-Spitz), we thinks is a variant of Spitz's nevus.

We cared for a patient with woolly-hair nevus (WHN) with hair of reduced diameter seen as oval shaped on transverse section. Scanning electron microscopy revealed a longitudinal canal along the length of the hair shaft. Although the association of WHN and epidermal nevus has been described previously, this report of their localization in the same site is, to our knowledge, the first in the literature.

A case of multicentric reticulohistiocytosis associated with bilateral Dupuytren's disease and xanthelasmas of the eyelids is described. Ultrastructural examination showed electron-dense intracytoplasmic granules, collagen entrapment and interdigitation of adjacent cytoplasmic membranes.

Four cases of segmental neurofibromatosis (SNF) are reported. It is a rare entity considered to be a localized variant of neurofibromatosis (NF)-Riccardi's type V. Two cases are male and two female. The lesions are located to the head in a patient and the other three cases in the trunk. No family history nor transmission to progeny were manifested. The rest of the organs are undamaged.

One hundred cases of chronic idiopathic urticaria (CIU) were studied to determine the incidence of leukocytoclastic vasculitis (LV) and the clinical and laboratory data that might indicate its presence. LV was found in 12 patients, none of whom had either clinical or laboratory data to suggest its presence. These results suggest that a small percentage of patients with CIU. 12% in this series, have LV without either clinical or laboratory signs of its existence.

This is the case history of a woman with a 6 year history of insulin-dependent diabetes mellitus and a 5 year history of tuberous lesions on the dorsal aspect of the metacarpophalangeal joints. Histological examination revealed multiple necrobiotic foci throughout the dermis and subcutaneous tissue, with varying degrees of degeneration, alternating with fibrotic areas. This picture is compatible with lipoid necrobiosis. The existence of various foci of epithelial perforation, manifested clinically by a point hyperkeratosis similar in appearance to blackheads, suggests transfollicular elimination. This would explain the total absence of a pilosebaceous follicles in the lesion.