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101. SARS-CoV-2: One Year in the Pandemic. What Have We Learned, the New Vaccine Era and the Threat of SARS-CoV-2 Variants

Author

Scialo, Filippo, primary, Vitale, Maria, additional, Daniele, Aurora, additional, Nigro, Ersilia, additional, Perrotta, Fabio, additional, Gelzo, Monica, additional, Iadevaia, Carlo, additional, Cerqua, Francesco Saverio, additional, Costigliola, Adriano, additional, Allocca, Valentino, additional, Amato, Felice, additional, Pastore, Lucio, additional, Castaldo, Giuseppe, additional, and Bianco, Andrea, additional

Published
2021
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102. Remarkable vessel enlargement within lung consolidation in COVID-19 compared to AH1N1 pneumonia: A retrospective study in Italy

Author

Bianco, Andrea, primary, Valente, Tullio, additional, Perrotta, Fabio, additional, Stellato, Elvira, additional, Brunese, Luca, additional, Wood, Brad J., additional, Carrafiello, Gianpaolo, additional, Parrella, Roberto, additional, Aronne, Luigi, additional, Boccia, Matilde, additional, Lassandro, Francesco, additional, Lassandro, Giulia, additional, Rea, Gaetano, additional, and Scialò, Filippo, additional

Published
2021
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103. Non-small cell lung cancer presenting as 'psoas muscle syndrome': A case report

Author

Mollica, Mariano, Maffucci, Rosalba, Lavoretano, Sabrina, Rea, Gaetano, Cerqua, Francesco Saverio, Aronne, Luigi, Bianco, Andrea, Perrotta, Fabio, Mollica, Mariano, Maffucci, Rosalba, Lavoretano, Sabrina, Rea, Gaetano, Cerqua, Francesco Saverio, Aronne, Luigi, Bianco, Andrea, and Perrotta, Fabio

Subjects
Psoas muscle syndrome, Skeletal muscles metastases, NSCLC, Skeletal muscles metastase
Abstract

Lung cancer is the leading cause of cancer-related death worldwide and majority of patients are diagnosed in advanced/metastatic disease stage. Sites of distant metastases mainly include contralateral lung, lymph nodes, brain, bones, adrenal glands and liver; skeletal muscles metastases (SMMs) are less common. Psoas muscle and diaphragm metastases are mainly found during autopsy, as their involvement commonly is asymptomatic. We report a case of a 60-year-old female, suffering from non-small cell lung cancer (NSCLC), with refractory lower back pain, as expression of malignant psoas syndrome (MPS). MPS is a rare and difficult-to-treat cancer-pain syndrome, unresponsive to majority of analgesic therapy, related to psoas muscle metastasis; it is usually caused by different tumors such as uterus, ovary, bladder, prostate, colon-rectum, lymphoma, melanoma and sarcoma and represents an uncommon finding in NSCLC patients.

Published
2019

105. Impact of Physical Activity on Disability Risk in Elderly Patients Hospitalized for Mild Acute Diverticulitis and Diverticular Bleeding Undergone Conservative Management

Author

Rocca, Aldo, primary, Brunese, Maria Chiara, additional, Cappuccio, Micaela, additional, Scacchi, Andrea, additional, Martucci, Gennaro, additional, Buondonno, Antonio, additional, Perrotta, Fabio Massimo, additional, Quarto, Gennaro, additional, Avella, Pasquale, additional, and Amato, Bruno, additional

Published
2021
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108. Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways

Author

Nigro, Ersilia, Perrotta, Fabio, Polito, Rita, D’Agnano, Vito, Scialò, Filippo, Bianco, Andrea, and Daniele, Aurora

Subjects
Article Subject
Abstract

Coronavirus disease (COVID-19) is caused by SARS-CoV-2 virus, which can result in serious respiratory illnesses such as pneumonia leading to respiratory failure. It was first reported in Wuhan, Hubei, China, in December 2019 and rapidly spread globally, becoming a pandemic in March 2020. Among comorbidities observed in SARS-CoV-2 positive patients, hypertension (68.3%) and type 2-diabetes (30.1%) are the most frequent conditions. Although symptoms are highly heterogeneous (ranging from absence of symptoms to severe acute respiratory failure), patients with metabolic-associated diseases often experience worse COVID-19 outcomes. This review investigates the association between metabolic disorders and COVID-19 severity, exploring the molecular mechanisms potentially underlying this relationship and those that are responsible for more severe COVID-19 outcomes. In addition, the role of the main biological processes that may connect metabolic alterations to SARS-CoV-2 infection such as hyperglycemia, immune system deregulation, ACE-2 receptor modulation, and inflammatory response is described. The impact of metabolic disorders on the prognosis of COVID-19 has major implications in public health especially for countries affected by a high incidence of metabolic diseases.

Published
2020
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116. Response

Author

Perrotta, Fabio, primary, Kerr, Keith M., additional, and Navani, Neal, additional

Published
2020
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127. Effectiveness of home-based preoperative pulmonary rehabilitation in COPD patients undergoing lung cancer resection

Author

Rispoli, Marco, primary, Salvi, Rosario, additional, Cennamo, Antonio, additional, Di Natale, Davide, additional, Natale, Giovanni, additional, Meoli, Ilernando, additional, Gioia, Maria Rosaria, additional, Esposito, Marianna, additional, Nespoli, Moana Rossella, additional, De Finis, Mario, additional, Buono, Salvatore, additional, Corcione, Antonio, additional, Lavoretano, Sabrina, additional, Bianco, Andrea, additional, Fiorelli, Alfonso, additional, Curcio, Carlo, additional, and Perrotta, Fabio, additional

Published
2020
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129. Effectiveness of Adalimumab for the Treatment of Psoriatic Arthritis: An Italian Real-Life Retrospective Study

Author

D'Angelo, Salvatore, primary, Cantini, Fabrizio, additional, Ramonda, Roberta, additional, Cantarini, Luca, additional, Carletto, Antonio, additional, Chimenti, Maria Sole, additional, Delle Sedie, Andrea, additional, Foti, Rosario, additional, Gerli, Roberto, additional, Lomater, Claudia, additional, Lubrano, Ennio, additional, Marchesoni, Antonio, additional, Zabotti, Alen, additional, Salvarani, Carlo, additional, Scrivo, Rossana, additional, Scarpa, Raffaele, additional, Tramontano, Giuseppina, additional, Nannini, Carlotta, additional, Lorenzin, Mariagrazia, additional, Fabbroni, Marta, additional, Martinis, Federica, additional, Perricone, Roberto, additional, Carli, Linda, additional, Visalli, Elisa, additional, Rovera, Guido, additional, Perrotta, Fabio Massimo, additional, Quartuccio, Luca, additional, Altobelli, Alessio, additional, Costa, Luisa, additional, Niccoli, Laura, additional, Ortolan, Augusta, additional, and Caso, Francesco, additional

Published
2019
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135. MRI Assessment of Extra-axial Findings at Pelvic Sites in a Group of Axial-SpA Patients.

Author

Perrotta, Fabio Massimo, Scriffignano, Silvia, and Lubrano, Ennio

Subjects
*MAGNETIC resonance imaging, *PUBIC symphysis, *SACROILIAC joint, *HIP joint, *DEMOGRAPHIC characteristics, *BURSITIS, *OSTEITIS
Abstract

Introduction: MRI allows a better evaluation of inflammatory and structural lesions of the sacroiliac joints and spine in patients with axial spondyloarthritis (axial SpA), so MRI plays an important role in the classification and diagnosis of axial SpA. The aim of our study was to assess extra-axial MRI findings at pelvic sites and their possible associations with clinical indices in patients with axial SpA. Methods: Axial-SpA patients who were classified according to the ASAS criteria and consecutively attended our clinic were assessed with pelvic MRI. The main clinical and demographic characteristics of all patients, including age, sex, BMI, presence of HLA-B27 and type of axial SpA (radiographic or nonradiographic), were evaluated. The main indices of disease activity and joint function were assessed, including BASDAI, ASDAS-PCR, BASMI and BASFI. Finally, the presence/absence of inflammatory/structural lesions at extra-axial structures (the hip joints, pubic symphysis, greater and lesser trochanters, ischial tuberosity, iliac spines and iliac crest) was evaluated. Results: 35 patients (21 males and 14 females) with a mean age (SD) of 47 (12.7) years and a mean duration of symptoms of 5 (2.1) years were enrolled. Hip abnormalities were found in 14 (40%) patients. Trochanteric enthesopathy/bursitis and pubic osteitis were found in 2 patients (5.7%) and 1 patient (2.8%), respectively. No other abnormalities were found at other sites. We found significant associations between the presence of extra-axial alterations, disease activity and joint function. Conclusions: Our study demonstrated the presence of extra-axial abnormalities in more than one-third of patients with axial SpA, suggesting that MRI evaluation should be extended to the entire pelvis. [ABSTRACT FROM AUTHOR]

Published
2021
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137. Effects of a high-intensity pulmonary rehabilitation program on the minute ventilation/carbon dioxide output slope during exercise in a cohort of patients with COPD undergoing lung resection for non-small cell lung cancer

Author

Perrotta, Fabio, Cennamo, Antonio, Cerqua, Francesco Saverio, Stefanelli, Francesco, Bianco, Andrea, Musella, Salvatore, Rispoli, Marco, Salvi, Rosario, Meoli, Ilemando, Perrotta, F., Cennamo, A., Cerqua, F. S., Stefanelli, F., Bianco, A., Musella, S., Rispoli, M., Salvi, R., and Meoli, I.

Subjects
Pulmonary and Respiratory Medicine, Spirometry, medicine.medical_treatment, Chronic obstructive/ rehabilitation, Câncer de Pulmão, Diseases of the respiratory system, 03 medical and health sciences, 0302 clinical medicine, DLCO, medicine, Pulmonary rehabilitation, Carbon dioxide/metabolism, 030212 general & internal medicine, DPOC, Inclinação VE/VCO2, Prospective cohort study, Lung cancer, Risk assessment, COPD, Pulmonary disease, chronic obstructive/rehabilitation, RC705-779, medicine.diagnostic_test, business.industry, Carcinoma, Non-small-cell lung, Reabilitação, Avaliação de Risco Pré-operatório, Retrospective cohort study, Carcinoma, non-small-cell lung, medicine.disease, respiratory tract diseases, 030228 respiratory system, Anesthesia, Oxygen consumption/physiology, Original Article, Pulmonary disease, business, Respiratory minute volume
Abstract

Objective: Preoperative functional evaluation is central to optimizing the identification of patients with non-small cell lung cancer (NSCLC) who are candidates for surgery. The minute ventilation/carbon dioxide output (VE/VCO2) slope has proven to be a predictor of surgical complications and mortality. Pulmonary rehabilitation programs (PRPs) could influence short-term outcomes in patients with COPD undergoing lung resection. Our objective was to evaluate the effects of a PRP on the VE/VCO2 slope in a cohort of patients with COPD undergoing lung resection for NSCLC. Methods: We retrospectively evaluated 25 consecutive patients with COPD participating in a three-week high-intensity PRP prior to undergoing lung surgery for NSCLC, between December of 2015 and January of 2017. Patients underwent complete functional assessment, including spirometry, DLCO measurement, and cardiopulmonary exercise testing. Results: There were no significant differences between the mean pre- and post-PRP values (% of predicted) for FEV1 (61.5 ± 22.0% vs. 62.0 ± 21.1%) and DLCO (67.2 ± 18.1% vs. 67.5 ± 13.2%). Conversely, there were significant improvements in the mean peak oxygen uptake (from 14.7 ± 2.5 to 18.2 ± 2.7 mL/kg per min; p < 0.001) and VE/VCO2 slope (from 32.0 ± 2.8 to 30.1 ± 4.0; p < 0.01). Conclusions: Our results indicate that a high-intensity PRP can improve ventilatory efficiency in patients with COPD undergoing lung resection for NSCLC. Further comprehensive prospective studies are required to corroborate these preliminary results. RESUMO Objetivos: A avaliação funcional pré-operatória é fundamental para otimizar a seleção dos pacientes para cirurgia torácica para tratamento do CPCNP. Uma alta inclinação VE/VCO2 se mostrou um preditor de complicações cirúrgicas e de aumento da mortalidade. Programas de reabilitação pulmonar (PRP) demonstraram aumentar os parâmetros funcionais e os desfechos de curto prazo em pacientes com DPOC submetidos à ressecção pulmonar. O impacto dos PRP na inclinação VE/VCO2 não foi totalmente investigado. Métodos: Avaliamos retrospectivamente 25 pacientes com DPOC consecutivos submetidos aos efeitos de um programa de reabilitação pulmonar de alta intensidade (PRP) na inclinação VE/VCO2. Resultados: Não foram observadas variações significativas nos principais parâmetros espirométricos após o programa de reabilitação de três semanas (pré-reabilitação VEF1 versus pós-reabilitação VEF1 %prev: 61,5 ± 22,0% para 62,0 ± 21,1%, ns; pré-reabilitação DLCO para pós-reabilitação DLCO %prev: 67,2 ± 18,1% para 67,5 ± 13,2%, ns). Por outro lado, o pico de VO2 e a inclinação VE/VCO2 melhoraram significativamente após PRP (pico de VO2 pré-reabilitação para pico de VO2 pós-reabilitação: 14,7 ± 2,5 para 18,2 ± 2,7 mL/kg/min, p < 0,0000001; inclinação pré-reabilitação VE/VCO2 para pós-reabilitação inclinação VE/VCO2: 32,0 ± 2,8 para 30,1 ± 4,0, p

Published
2019

139. The "Climb" Towards Minimal Disease Activity in Psoriatic Arthritis.

Author

Lubrano, Ennio, Scriffignano, Silvia, and Perrotta, Fabio Massimo

Subjects
PSORIATIC arthritis, JOINT pain, DISEASE progression, CROSS-sectional method
Abstract

Introduction: Minimal disease activity (MDA) is a validated outcome measure in psoriatic arthritis (PsA) defining a low disease activity state with a cutoff of 5/7. The main aim of the study was to look at the MDA divided into in the seven cutoffs, analyzing the more frequently achieved domains. The relationship between MDA, PASS, PsAID, DAPSA, and the PhGA in all cutoffs was also evaluated. Methods: Cross-sectional analysis on PsA patients satisfying CASPAR criteria. An assessment of disease activity, treatment target, function, and impact of disease was performed. Patients achieving MDA were compared to patients not achieving MDA in order to evaluate the most frequent domain found. Results: Ninety-three PsA patients were enrolled. MDA was satisfied in 44/93, while in 47 MDA ranged from 1/7 to 4/7. Among the seven domains, Leeds Enthesitis Index (LEI) was the most frequent domain found in all patients. In those not in MDA, BSA ≤ 3 (70%) and swollen joints count ≤ 1 (68%) were also well represented. The domains with a lower percentage of patients not in MDA were HAQ-DI ≤ 0.5 (38.8%), tender joint count ≤ 1 (23%), PtGA ≤ 20 (4.2%) and VAS pain ≤ 15 mm (2%). There was a growing trend, from MDA 1/7 to MDA 7/7 in the percentage of patients in PASS yes, in PsAID ≤ 4, and in DAPSA ≤ 14. Conclusions: The present study detailed the domains more achieved also in those patients not in MDA showing that "physician-driven" domains are more frequently achieved in our patients. [ABSTRACT FROM AUTHOR]

Published
2021
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140. New Insights in Physical Therapy and Rehabilitation in Psoriatic Arthritis: A Review.

Author

Perrotta, Fabio Massimo, Scriffignano, Silvia, Benfaremo, Devis, Ronga, Mario, Luchetti, Michele Maria, and Lubrano, Ennio

Subjects
*PSORIATIC arthritis, *PHYSICAL therapy, *REHABILITATION, *DISEASE remission, *RHEUMATOID arthritis, *QUALITY of life
Abstract

Psoriatic arthritis (PsA) is a complex, multiform and chronic inflammatory disease characterized by the association of psoriasis and arthritis with other musculoskeletal and extra-articular manifestations. The treatment of PsA is rapidly evolving due to the introduction of new biologic and small-molecule drugs, and the aim of treatment is to induce a condition of remission or low disease activity in all disease domains. However, unmet treatment needs still persist for those patients with impaired function, reduced quality of life or comorbidities. In this context, physical therapy and rehabilitation could provide additional benefits by reducing disease activity and improving function. Although a large number of studies have assessed the role of physical therapy and exercise in other forms of chronic inflammatory arthritis, such as axial spondyloarthritis and rheumatoid arthritis, evidence on their effect on persons with PsA is still lacking. However, some studies have reported the potential positive role of physical therapy on the different disease domains of PsA, in helping to improve disease activity, prevent or improve articular impairment, improve pain management and improve quality of life. Here, we review current evidence on physical therapy, exercise and rehabilitation in patients with PsA. In particular, we review the literature focusing on each domain, to provide evidence of efficacy and effectiveness of exercise and rehabilitation on skin, peripheral arthritis, axial involvement, dactylitis, enthesitis and comorbidities. [ABSTRACT FROM AUTHOR]

Published
2021
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143. Relevance of lung ultrasound in the diagnostic algorithm of respiratory diseases in a real‐life setting: A multicentre prospective study

Author

Rinaldi, Luca, primary, Milione, Stefania, additional, Fascione, Maria Chiara, additional, Pafundi, Pia Clara, additional, Altruda, Concetta, additional, Di Caterino, Mafalda, additional, Monaco, Lucio, additional, Reginelli, Alfonso, additional, Perrotta, Fabio, additional, Porta, Giovanni, additional, Venafro, Mario, additional, Acierno, Carlo, additional, Mastrocinque, Davide, additional, Giordano, Mauro, additional, Bianco, Andrea, additional, Sasso, Ferdinando Carlo, additional, and Adinolfi, Luigi Elio, additional

Published
2019
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146. Ultrasonographic and Clinical Assessment of Peripheral Enthesitis in Patients with Psoriatic Arthritis, Psoriasis, and Fibromyalgia Syndrome: The ULISSE Study

Author

Macchioni, Pierluigi, primary, Salvarani, Carlo, additional, Possemato, Niccolò, additional, Gutierrez, Marwin, additional, Grassi, Walter, additional, Gasparini, Stefania, additional, Perricone, Carlo, additional, Perrotta, Fabio Massimo, additional, Grembiale, Rosa Daniela, additional, Bruno, Caterina, additional, Tripolino, Cesare, additional, Govoni, Marcello, additional, Ciancio, Giovanni, additional, Farina, Ilaria, additional, Ramonda, Roberta, additional, Frallonardo, Paola, additional, Desiati, Francesca, additional, Scarpa, Raffaele, additional, Costa, Luisa, additional, Zabotti, Alen, additional, De Vita, Salvatore, additional, D’Attino, Rita Maria, additional, Gualberti, Giuliana, additional, Merolla, Rocco, additional, di Luzio Paparatti, Umberto, additional, Aldigeri, Raffaella, additional, and Marchesoni, Antonio, additional

Published
2019
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149. Clinical Characteristics of Potential “Difficult-to-treat” Patients with Psoriatic Arthritis: A Retrospective Analysis of a Longitudinal Cohort

Author

Perrotta, Fabio Massimo, Scriffignano, Silvia, Ciccia, Francesco, and Lubrano, Ennio

Abstract

Introduction: The EULAR group recently published the definition of difficult-to-treat (D2T) patients for rheumatoid arthritis. However, a similar definition is lacking for patients with psoriatic arthritis (PsA), in which its multi-domain expression may impact the treatment response. The aim of the study was to characterize the potential D2T PsA patients, to assess the risk factors, and to determine the burden of disease. Methods: Retrospective analysis of a longitudinal cohort of PsA patients attending a tertiary care center. At each visit, the patients underwent a complete physical examination and the clinical/laboratory data were collected. Data on comorbidities with the assessment of different comorbidity indices were also collected. Disease activity was assessed by using the DAPSA score and the MDA. The PsAID and HAQ-DI were also collected. We use the previous identified definition of D2T patients, applied to our PsA group and modified for this study. Results: A total of 106 patients fulfilled the inclusion criteria and were evaluated. Of these, 36 (33.9%) patients fulfilled the criteria for the potential D2T patients. D2T patients showed a significantly higher BMI and higher prevalence of fibromyalgia. Furthermore, D2T patients showed a significantly higher median Functional Comorbidity Index and a significantly higher BSA, LEI, pain level, PsAID score, and HAQ-DI than non-D2T patients. Potential D2T patients also showed a significant delay in the time from diagnosis to first b/ts DMARDs treatment. Conclusions: Our study firstly evaluated the presence of clinical characteristics of potential D2T patients and may contribute to future research on this intriguing aspect.

Published
2022
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