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101. Ovary-intact, but not ovariectomized female ACI rats treated with 17beta-estradiol rapidly develop mammary carcinoma.

Author

Shull, J D, Spady, T J, Snyder, M C, Johansson, S L, and Pennington, K L

Abstract

We have examined the ability of 17beta-estradiol (E2) to induce development of mammary cancers in the female ACI rat. Continuous treatment with E2, delivered through release from s.c. Silastic tubing implants containing 27.5 mg crystalline hormone, resulted in rapid development of palpable mammary tumors in ovary-intact ACI rats. In a population of 21 E2-treated rats, palpable tumors were first observed following 99 days treatment and 100% of the treated population developed tumors within 197 days. The median and mean times to appearance of first palpable tumor were 143 and 145 days respectively. All mammary tumors were classified as carcinomas and invasive features were observed. Circulating E2 levels in the treated animals at the time of sacrifice averaged 185 pg/ml serum. Mammary tumors were not observed in ovary-intact female ACI rats that were not treated with E2. This is the first report indicating that this naturally occurring estrogen is capable of inducing mammary cancers in the ACI rat strain. Mammary carcinoma did not develop in a population of 11 ovariectomized female ACI rats treated with E2 for a period of 140 days. Circulating E2 levels in the treated ovariectomized animals averaged 207 pg/ml. These data indicate that the ovary modulates estrogen-mediated mammary carcinogenesis in this rat strain. Both ovary-intact and ovariectomized female ACI rats displayed similar susceptibilities to E2-induced pituitary tumors and hyperprolactinemia. Pituitary weight was increased 6.0-fold in ovary-intact ACI rats and 5.3-fold in ovariectomized female rats. Circulating prolactin levels averaged 2318 ng/ml in E2-treated, ovary-intact rats and 2285 ng/ml in E2-treated, ovariectomized ACI rats. These data indicate that estrogen-induced hyperprolactinemia is not the sole factor leading to development of mammary cancers in the E2-treated ACI rat. [ABSTRACT FROM PUBLISHER]

Published
1997
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104. Protein kinase C and calcineurin synergize to activate IkappaB kinase and NF-kappaB in T lymphocytes.

Author

Trushin, S A, Pennington, K N, Algeciras-Schimnich, A, and Paya, C V

Abstract

The nuclear factor of kappaB (NF-kappaB) is a ubiquitous transcription factor that is key in the regulation of the immune response and inflammation. T cell receptor (TCR) cross-linking is in part required for activation of NF-kappaB, which is dependent on the phosphorylation and degradation of IkappaBalpha. By using Jurkat and primary human T lymphocytes, we demonstrate that the simultaneous activation of two second messengers of the TCR-initiated signal transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of the IkappaBalpha kinase (IKK) complex but not of another putative IkappaBalpha kinase, p90(rsk). We also demonstrate that the IKK complex, but not p90(rsk), is responsible for the in vivo phosphorylation of IkappaBalpha mediated by the co-activation of PKC and calcineurin. Each second messenger is necessary, as inhibition of either one reverses the activation of the IKK complex and IkappaBalpha phosphorylation in vivo. Overexpression of dominant negative forms of IKKalpha and -beta demonstrates that only IKKbeta is the target for PKC and calcineurin. These results indicate that within the TCR/CD3 signal transduction pathway both PKC and calcineurin are required for the effective activation of the IKK complex and NF-kappaB in T lymphocytes.

Published
1999

105. A COMPARISON OF ELECTRONIC AND PIPET METHODS FOR MECHANICAL ANALYSIS OF SOILS

Author

PENNINGTON, K. L. and LEWIS, G. C.

Abstract

An electronic method was developed and compared to the pipet method for determining particle size distribution of 43 samples representing a wide variety of Idaho soils. The Coulter Counter model TAII was used for the elctronic method. Thirty-seven of the 43 samples had the same textural clssification by both the electronic and pipet methods. There was significant correlation between the two methods in the amounts of clay and silt found in the soil samples. Approximately twice as many samples can be run by the electronic method in the same amount as by the pipet method.

Published
1979

106. Patent Reviews: 3,785,262; 3,785,265; 3,786,180; 3,786,238; 3,790,284; 3,792,915; 3,794,406; 3,796,476; 3,796,494; 3,796,887; 3,797,907; 3,797,910; 3,797,922; 3,799,653; 3,799,654; 3,800,149; 3,801,181; 3,801,188

Author

Lovell, D. J., Ball, J. J., Mooney, C. F., Barns, R. L., Nielsen, J. W., Birks, L. S., Palik, E. D., Cleek, G. W., Pennington, K. S., Du Pré, E. F., Rubinstein, C. B., Gibson, G. L., Shenker, H., Harper, D. C., Shepard, C., Hilliard, R. L., Staunton, J. J. J., Howell, B. J., Sullivan, D. L., Hyde, W. L., Tchejeyan, S. K., Jacobs, S. F., Vargady, L. O., Kingslake, R., Wakeling, P. R., Lurie, M., Weigl, F., Manring, E., Williamson, D. E., Meyer-Arendt, J. R., and Wood, D. L.

Abstract

The patent number, date of issuance by the U.S. Patent Office, and classification are shown on the first line. The filing date is that of the first application (although some patents may derive from earlier applications with earlier claim dates). Any opinions expressed are those of the reviewers and do not reflect the opinions of the organizations with which they are associated, the Optical Society of America, or this journal. Printed copies of these patents may be ordered from the Commissioner of Patents, Washington, DC 20231: telephone (703) 557-3158, URL http://patents.uspto.gov. Inquiries about patents should be addressed to the Patents Office, not to this journal or to OSA.

Published
1974

107. Patent Reviews: 3,711,199; 3,716,286; 3,716,287; 3,718,074; 3,720,779; 3,723,010; 3,724,943; 3,729,634; 3,731,265; 3,731,993; 3,739,093; 3,740,111; 3,752,556; 3,754,814; 3,756,683; 3,758,186; 3,764,979; 3,784,310; 3,784,377; 3,785,724; 3,786,366; 3,787,112; 3,788,745; 3,791,719; 3,791,720; 3,802,765; 3,803,510; 3,804,494; 3,804,496; 3,804,528; 3,804,531; 3,804,619; 3,805,186; 3,806,231; 3,806,237; 3,806,725; 3,806,871; 3,807,835; 3,807,836; 3,809,457; 3,810,042; 3,810,693; 3,811,095; 3,811,748; 3,811,749; 3,811,754; 3,813,158; 3,813,552; 3,813,611

Author

Ball, J. J., Mooney, C. F., Barns, R. L., Nielsen, J. W., Birks, L. S., Palik, E. D., Cleek, G. W., Pennington, K. S., Du Pré, E. F., Rubinstein, C. B., Gibson, G. L., Shenker, H., Harper, D. C., Shepard, C., Hilliard, R. L., Staunton, J. J. J., Howell, B. J., Sullivan, D. L., Hyde, W. L., Tcliejeyan, S. K., Jacobs, S. F., Vargady, L. O., Kingslake, R., Wakeling, P. R., Lurie, M., Weigl, F., Manring, E., Williamson, D. E., Meyer-Arendt, J. R., and Wood, D. L.

Abstract

The patent number, date of issuance by the U.S. Patent Office, and classification are shown on the first line. The filing date is that of the first application (although some patents may derive from earlier applications with earlier claim dates). Any opinions expressed are those of the reviewers and do not reflect the opinions of the organizations with which they are associated, the Optical Society of America, or this journal. Printed copies of these patents may be ordered from the Commissioner of Patents, Washington, DC 20231: telephone (703) 557-3158, URL http://patents.uspto.gov. Inquiries about patents should be addressed to the Patents Office, not to this journal or to OSA.

Published
1974

109. Patent Reviews: 3,841,733; 3,973,827; 4,052,119; 3,977,789; 3,980,811; 3,987,421; 4,023,906; 4,039,245; 4,025,194; 4,025,195; 4,037,918; 4,025,786; 4,037,919; 4,039,833; 4,042,822; 4,046,456; 4,048,515; 4,049,963; 4,053,919; 4,054,358; 4,057,317; 4,058,734; 4,058,722; 4,059,343; 4,060,311; 4,060,327; 4,062,045

Author

Lovell, D. J., Astheimer, R., Jacobs, S. F., Petty, C. C., Ball, J. J., Kingslake, R., Prescott, R., Barns, R. L., Lurie, M., Rubinstein, C. B., Birks, L. S., Mann, A., Staunton, J. J. J., Cleek, G. W., Manring, E., Sullivan, D. L., Decker, J. A., Marshall, G., Tchejeyan, S. K., Ezekiel, S., Meyer-Arendt, J. R., Vargady, L. O., Harper, D. C., Miranda, H., Vaughan, W., Hilliard, R. L., Mooney, C. F., Wakeling, P., Howell, B. J., Nielsen, J. W., Williamson, D. E., Hyde, W. L., Palik, E. D., Zimmerman, J., and Pennington, K. S.

Abstract

The patent number, date of issuance by the U.S. Patent Office, and classification are shown on the first line. The filing date is that of the first application (although some patents may derive from earlier applications with earlier claim dates). Any opinions expressed are those of the reviewers and do not reflect the opinions of the organizations with which they are associated, the Optical Society of America, or this journal. Printed copies of these patents may be ordered from the Commissioner of Patents, Washington, DC 20231: telephone (703) 557-3158, URL http://patents.uspto.gov. Inquiries about patents should be addressed to the Patents Office, not to this journal or to OSA.

Published
1978

110. Patent Reviews: 3,706,495; 3,708,222; 3,796,493; 3,796,498; 3,814,505; 3,814,510; 3,817,599; 3,816,735; 3,817,600; 3,817,602; 3,818,125; 3,819,253; 3,819,256; 3,820,876; 3,820,897; 3,821,466; 3,821,551; 3,822,087; 3,822,931; 3,822,096; 3,822,932; 3,824,005; 3,824,549; 3,825,315; 3,825,316; 3,825,321; 3,825,326; 3,825,328; 3,825,346; 3,826,992; 3,827,062; 3,827,781; 3,827,786; 3,827,793; 3,828,187; 3,829,198; 3,830,558; 3,830,559; 3,830,571; 3,832,028; 3,832,029; 3,832,030; 3,833,284; 3,833,286; 3,833,290; 3,833,810

Author

Lovell, D. J., Ball, J. J., Mooney, C. F., Barns, R. L., Nielsen, J. W., Birks, L. S., Palik, E. D., Cleek, G. W., Pennington, K. S., Du Pré, E. F., Rubinstein, C. B., Gibson, G. L., Shenker, H., Harper, D. C., Shepard, C., Hilliard, R. L., Staunton, J. J. J., Howell, B. J., Sullivan, D. L., Hyde, W. L., Tchejeyan, S. K., Jacobs, S. F., Vargady, L. O., Kingslake, R., Wakeling, P. R., Lurie, M., Weigl, F., Manring, E., Williamson, D. E., Meyer-Arendt, J. R., and Wood, D. L.

Abstract

The patent number, date of issuance by the U.S. Patent Office, and classification are shown on the first line. The filing date is that of the first application (although some patents may derive from earlier applications with earlier claim dates). Any opinions expressed are those of the reviewers and do not reflect the opinions of the organizations with which they are associated, the Optical Society of America, or this journal. Printed copies of these patents may be ordered from the Commissioner of Patents, Washington, DC 20231: telephone (703) 557-3158, URL http://patents.uspto.gov. Inquiries about patents should be addressed to the Patents Office, not to this journal or to OSA.

Published
1975

111. A Steering Bogie for the British Rail Class 37 Locomotive

Author

Pennington, K W, Harwood, N A, and Peat, D M

Abstract

This paper describes the theoretical and practical design studies undertaken to improve the curving perfornrance of the British Rail Class 37 Co–Co locomotive to reduce expensive wheel and rail wear on the West Highland Line. Observatiomfrom preliminary performance trials with a locomotivejitted with prototype steering bogies are also discussed. It is shown how a traditional design can be improved through current theoretical understanding to provide a practical solution to an operating problem.

Published
1986
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112. Filtering of Defects in Integrated Circuits with Orientation Independence

Author

Will, P. M. and Pennington, K. S.

Abstract

Defect enhancement in semiconductor wafers is shown to be possible by spatial frequency filtering without the necessity for filter alignment. The technique depends on the wafer being sufficiently periodic. Coherent optical and digital computer simulation results are presented.

Published
1971

113. Techniques for Producing Low-Noise, Improved Efficiency Holograms

Author

Pennington, K. S. and Harper, J. S.

Abstract

Photographic processing techniques for producing high efficiency, low noise phase holograms on silver halide emulsions have been investigated. Control of the emulsion and maintenance of the integrity of the holographic record throughout all processing were identified as prime requisites for high quality holographic reconstructions. Holograms have been obtained which yield approximately 30% diffraction efficiency and signal to scattered noise (S/N) in excess of 50:1 in the reconstruction of a diffuse wavefront. Holographic interferometry and ghost imaging with diffuse subjects has also been achieved with these techniques.

Published
1970

116. Multicolor Imaging from Holograms Formed on Two-Dimensional Media

Author

Collier, R. J. and Pennington, K. S.

Abstract

Multicolor image reconstruction from holograms behaving as two-dimensional media suffer severely from overlap of the similarly structured crosstalk images unless special techniques are used in formation. This paper describes examples of two techniques which eliminate the crosstalk images. The first technique involves nonoverlapping spatial multiplexing and is illustrated by interlacing on the hologram the colored images of a mask placed in the reference beam. The second technique involves coding the reference beam so that each colored reference wave varies in a unique manner over the hologram plate. Photographs of the resulting multicolor reconstructions are shown.

Published
1967

121. GIUSEPPE DOSSETTI STUDIES ON AN ITALIAN CATHOLIC REFORMER

Author

Alberto MELLONI, Bianchi, E., Ruggieri, G., R, Horn G., Onida, V., Balboni, E., Bettiolo, P., Galavotti, E., Pennington, K., Fornaciari, R., Raguer, H., Garuti, P., Giorgi, L., Albonetti, P., Dossetti, G. L., Adda, D. C., Alberani, A., Fanti, G., Buonasorte, N., Lanne, E., and La Valle, R.

122. A unified call to action from Australian nursing and midwifery leaders: Ensuring that Black lives matter

Author

Geia, Lynore, Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., De Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, Christine M, Dunning, T., East, L., Elliott, D., Elmir, R., Fergie, D., Ferguson, C., Fernandez, R., Flower, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer, C. S. E., Hungerford, C., Hutton, A., Jackson, D., Johnson, A., Kelly, M. A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, A.M.R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Philips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., Wynne, R., Geia, Lynore, Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., Birks, M., Blackley, L., Blackman, R., Bonner, A., Bryant AO, R., Buzzacott, C., Campbell, S., Catling, C., Chamberlain, C., Cox, L., Cross, W., Cruickshank, M., Cummins, A., Dahlen, H., Daly, J., Darbyshire, P., Davidson, P., Denney-Wilson, E., De Souza, R., Doyle, K., Drummond, A., Duff, J., Duffield, Christine M, Dunning, T., East, L., Elliott, D., Elmir, R., Fergie, D., Ferguson, C., Fernandez, R., Flower, D., Foureur, M., Fowler, C., Fry, M., Gorman, E., Grant, J., Gray, J., Halcomb, E., Hart, B., Hartz, D., Hazelton, M., Heaton, L., Hickman, L., Homer, C. S. E., Hungerford, C., Hutton, A., Jackson, D., Johnson, A., Kelly, M. A., Kitson, A., Knight, S., Levett-Jones, T., Lindsay, D., Lovett, R., Luck, L., Molloy, L., Manias, E., Mannix, J., Marriott, A.M.R., Martin, M., Massey, D., McCloughen, A., McGough, S., McGrath, L., Mills, J., Mitchell, B. G., Mohamed, J., Montayre, J., Moroney, T., Moyle, W., Moxham, L., Northam, H., Nowlan, S., O'Brien, A. P., Ogunsiji, O., Paterson, C., Pennington, K., Peters, K., Philips, J., Power, T., Procter, N., Ramjan, L., Ramsay, N., Rasmussen, B., Rihari-Thomas, J., Rind, B., Robinson, M., Roche, M., Sainsbury, K., Salamonson, Y., Sherwood, J., Shields, L., Sim, J., Skinner, I., Smallwood, G., Smallwood, R., Stewart, L., Taylor, S., Usher, K., Virdun, C., Wannell, J., Ward, R., West, C., West, R., Wilkes, L., Williams, R., Wilson, R., Wynaden, D., and Wynne, R.

Abstract

Geia, L., Baird, K., Bail, K., Barclay, L., Bennett, J., Best, O., ... Wynne, R. (2020). A unified call to action from Australian nursing and midwifery leaders: Ensuring that Black lives matter. Contemporary Nurse, 56(4), 297-308. https://doi.org/10.1080/10376178.2020.1809107

123. Interactive effects of DRD2 rs6277 polymorphism, environment and sex on impulsivity in a population-representative study

Author

Klaus, K., Vaht, M., Pennington, K., Harro, J., Klaus, K., Vaht, M., Pennington, K., and Harro, J.

Abstract

Previous research has shown that dopaminergic dysregulation and early life stress interact to impact on aspects of impulse control. This study aimed to explore the potentially interactive effects of the rs6277 polymorphism of the dopamine D2 receptor gene (DRD2), stressful or supportive environment and sex on behavioural and self-reported measures of impulsivity, as well as alcohol use – a condition characterised by a deficit in impulse control. The sample consisted of the younger cohort (n = 583) of the longitudinal Estonian Children Personality, Behaviour and Health Study. The results showed that the CC homozygotes (suggested to have decreased striatal D2 receptor availability) who had experienced stressful life events (SLE) or maltreatment in the family prior to age 15 showed higher self-reported maladaptive impulsivity at age 15. The genotype-SLE interaction and further association with sex was also evident in the frequency of alcohol use at age 15. Lack of warmth in the family contributed to significantly higher levels of thoughtlessness and more frequent alcohol use in CC carriers at age 25, whereas family support was associated with lower thoughtlessness scores in CC males, which may suggest a protective effect of supportive family environment in this group. Together the findings suggest that DRD2 rs6277 polymorphism, in interaction with environmental factors experienced in childhood and youth may affect facets of impulsivity. Future work should aim to further clarify the sex and age-specific effects of stressful and supportive environment on the development of neuronal systems that are compromised in disorders characterised by deficits in impulse control.

124. A unified call to action from Australian Nursing and Midwifery leaders: ensuring that Black Lives Matter

Author

Geia, L, Baird, K, Bail, K, Barclay, L, Bennett, J, Best, O, Birks, M, Blackley, L, Blackman, R, Bonner, A, Bryant AO, R, Kitson, A, Knight, S, Levett-Jones, T, Lindsay, D, Lovett, R, Luck, L, Malloy, L, Manias, E, Mannix, J, Marriott AM, R, Mills, J, Martin, M, Massey, D, McCloughen, A, McGough, S, McGrath, L, Mitchell, B, Mohamed, J, Montayre, J, Moroney, T, Moyle, W, Moxham, L, Northam AM, H, Nowlan, S, O'Brien, T, Power, T, Ogunsiji, O, Patterson, C, Pennington, K, Peters, K, Phillips, J, Procter, N, Ramjan, L, Ramsay, N, Rasmussen, B, Rihari-Thomas, J, Rind, B, Robinson, M, Roche, M, Sainsbury, K, Smallwood, G, Salamonson, Y, Sherwood, J, Shields, L, Sim, J, Skinner, I, Smallwood, R, Stewart, L, Taylor, S, Usher AM, K, Virdun, C, Wannell, J, Ward, R, West, C, West, R, Buzzacott, C, Wilkes, L, Williams, R, Wilson, R, Wynaden, D, Wynn, R, Campbell, S, Catling, C, Chamberlain, C, Cox, L, Cross, W, Cruickshank, M, Cummins, A, Dahlen, H, Daly, J, Darbyshire, P, Davidson, P, Denny-Wilson, E, De Souza, R, Doyle, K, Drummond, A, Duff, J, Duffield, C, Dunning, T, East, L, Elliott, D, Elmir, R, Fergie, D, Ferguson, C, Fernandez, R, Flower AM, D, Foureur, M, Fowler, C, Fry, M, Gorman, E, Grant, J, Gray, J, Halcomb, E, Hart, B, Hartz, D, Hazelton, M, Heaton, L, Hickman, L, Homer, C, Hungerford, C, Hutton, A, Jackson AO, D, Johnson, A, Kelly, M, Geia, L, Baird, K, Bail, K, Barclay, L, Bennett, J, Best, O, Birks, M, Blackley, L, Blackman, R, Bonner, A, Bryant AO, R, Kitson, A, Knight, S, Levett-Jones, T, Lindsay, D, Lovett, R, Luck, L, Malloy, L, Manias, E, Mannix, J, Marriott AM, R, Mills, J, Martin, M, Massey, D, McCloughen, A, McGough, S, McGrath, L, Mitchell, B, Mohamed, J, Montayre, J, Moroney, T, Moyle, W, Moxham, L, Northam AM, H, Nowlan, S, O'Brien, T, Power, T, Ogunsiji, O, Patterson, C, Pennington, K, Peters, K, Phillips, J, Procter, N, Ramjan, L, Ramsay, N, Rasmussen, B, Rihari-Thomas, J, Rind, B, Robinson, M, Roche, M, Sainsbury, K, Smallwood, G, Salamonson, Y, Sherwood, J, Shields, L, Sim, J, Skinner, I, Smallwood, R, Stewart, L, Taylor, S, Usher AM, K, Virdun, C, Wannell, J, Ward, R, West, C, West, R, Buzzacott, C, Wilkes, L, Williams, R, Wilson, R, Wynaden, D, Wynn, R, Campbell, S, Catling, C, Chamberlain, C, Cox, L, Cross, W, Cruickshank, M, Cummins, A, Dahlen, H, Daly, J, Darbyshire, P, Davidson, P, Denny-Wilson, E, De Souza, R, Doyle, K, Drummond, A, Duff, J, Duffield, C, Dunning, T, East, L, Elliott, D, Elmir, R, Fergie, D, Ferguson, C, Fernandez, R, Flower AM, D, Foureur, M, Fowler, C, Fry, M, Gorman, E, Grant, J, Gray, J, Halcomb, E, Hart, B, Hartz, D, Hazelton, M, Heaton, L, Hickman, L, Homer, C, Hungerford, C, Hutton, A, Jackson AO, D, Johnson, A, and Kelly, M

125. A unified call to action from Australian Nursing and Midwifery leaders: ensuring that Black Lives Matter

Author

Geia, L, Baird, K, Bail, K, Barclay, L, Bennett, J, Best, O, Birks, M, Blackley, L, Blackman, R, Bonner, A, Bryant AO, R, Kitson, A, Knight, S, Levett-Jones, T, Lindsay, D, Lovett, R, Luck, L, Malloy, L, Manias, E, Mannix, J, Marriott AM, R, Mills, J, Martin, M, Massey, D, McCloughen, A, McGough, S, McGrath, L, Mitchell, B, Mohamed, J, Montayre, J, Moroney, T, Moyle, W, Moxham, L, Northam AM, H, Nowlan, S, O'Brien, T, Power, T, Ogunsiji, O, Patterson, C, Pennington, K, Peters, K, Phillips, J, Procter, N, Ramjan, L, Ramsay, N, Rasmussen, B, Rihari-Thomas, J, Rind, B, Robinson, M, Roche, M, Sainsbury, K, Smallwood, G, Salamonson, Y, Sherwood, J, Shields, L, Sim, J, Skinner, I, Smallwood, R, Stewart, L, Taylor, S, Usher AM, K, Virdun, C, Wannell, J, Ward, R, West, C, West, R, Buzzacott, C, Wilkes, L, Williams, R, Wilson, R, Wynaden, D, Wynn, R, Campbell, S, Catling, C, Chamberlain, C, Cox, L, Cross, W, Cruickshank, M, Cummins, A, Dahlen, H, Daly, J, Darbyshire, P, Davidson, P, Denny-Wilson, E, De Souza, R, Doyle, K, Drummond, A, Duff, J, Duffield, C, Dunning, T, East, L, Elliott, D, Elmir, R, Fergie, D, Ferguson, C, Fernandez, R, Flower AM, D, Foureur, M, Fowler, C, Fry, M, Gorman, E, Grant, J, Gray, J, Halcomb, E, Hart, B, Hartz, D, Hazelton, M, Heaton, L, Hickman, L, Homer, C, Hungerford, C, Hutton, A, Jackson AO, D, Johnson, A, Kelly, M, Geia, L, Baird, K, Bail, K, Barclay, L, Bennett, J, Best, O, Birks, M, Blackley, L, Blackman, R, Bonner, A, Bryant AO, R, Kitson, A, Knight, S, Levett-Jones, T, Lindsay, D, Lovett, R, Luck, L, Malloy, L, Manias, E, Mannix, J, Marriott AM, R, Mills, J, Martin, M, Massey, D, McCloughen, A, McGough, S, McGrath, L, Mitchell, B, Mohamed, J, Montayre, J, Moroney, T, Moyle, W, Moxham, L, Northam AM, H, Nowlan, S, O'Brien, T, Power, T, Ogunsiji, O, Patterson, C, Pennington, K, Peters, K, Phillips, J, Procter, N, Ramjan, L, Ramsay, N, Rasmussen, B, Rihari-Thomas, J, Rind, B, Robinson, M, Roche, M, Sainsbury, K, Smallwood, G, Salamonson, Y, Sherwood, J, Shields, L, Sim, J, Skinner, I, Smallwood, R, Stewart, L, Taylor, S, Usher AM, K, Virdun, C, Wannell, J, Ward, R, West, C, West, R, Buzzacott, C, Wilkes, L, Williams, R, Wilson, R, Wynaden, D, Wynn, R, Campbell, S, Catling, C, Chamberlain, C, Cox, L, Cross, W, Cruickshank, M, Cummins, A, Dahlen, H, Daly, J, Darbyshire, P, Davidson, P, Denny-Wilson, E, De Souza, R, Doyle, K, Drummond, A, Duff, J, Duffield, C, Dunning, T, East, L, Elliott, D, Elmir, R, Fergie, D, Ferguson, C, Fernandez, R, Flower AM, D, Foureur, M, Fowler, C, Fry, M, Gorman, E, Grant, J, Gray, J, Halcomb, E, Hart, B, Hartz, D, Hazelton, M, Heaton, L, Hickman, L, Homer, C, Hungerford, C, Hutton, A, Jackson AO, D, Johnson, A, and Kelly, M

129. Patents patter: a comment

Author

Greenstein, Howard, primary, Lovell, D. J., additional, Astheimer, R., additional, Jacobs, S. F., additional, Petty, C. C., additional, Ball, J. J., additional, Kingslake, R., additional, Prescott, R., additional, Barns, R. L., additional, Lurie, M., additional, Rubinstein, C. B., additional, Birks, L. S., additional, Mann, A., additional, Staunton, J. J. J., additional, Cleek, G. W., additional, Manring, E., additional, Sullivan, D. L., additional, Decker, J. A., additional, Marshall, G., additional, Tchejeyan, S. K., additional, Ezekiel, S., additional, Meyer-Arendt, J. R., additional, Vargady, L. O., additional, Harper, D. C., additional, Miranda, H., additional, Vaughan, W., additional, Hilliard, R. L, additional, Mooney, C. F., additional, Wakeling, P., additional, Howell, B.J., additional, Nielsen, J. W., additional, Williamson, D. E., additional, Hyde, W. L., additional, Palik, E. D., additional, Zimmerman, J., additional, and Pennington, K. S., additional

Published
1978
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132. Patent Reviews: 3,886,474; 3,936,768; 3,947,781; 3,983,507; 3,886,483; 3,983,508; 4,042,892; 4,050,035; 4,053,851; 4,058,778

Author

Lovell, D. J., primary, Astheimer, R., additional, Jacobs, S. F., additional, Petty, C. C., additional, Ball, J. J., additional, Kingslake, R., additional, Prescott, R., additional, Barns, R. L., additional, Lurie, M., additional, Rubinstein, C. B., additional, Birks, L. S., additional, Mann, A., additional, Staunton, J. J. J., additional, Cleek, G. W., additional, Manring, E., additional, Sullivan, D. L., additional, Decker, J. A., additional, Marshall, G., additional, Tchejeyan, S. K., additional, Ezekiel, S., additional, Meyer-Arendt, J. R., additional, Vargady, L. O., additional, Harper, D. C., additional, Miranda, H., additional, Vaughan, W., additional, Hilliard, R. L., additional, Mooney, C. F., additional, Wakeling, P., additional, Howell, B. J., additional, Nielsen, J. W., additional, Williamson, D. E., additional, Hyde, W. L., additional, Palik, E. D., additional, Zimmerman, J., additional, and Pennington, K. S., additional

Published
1978
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141. The expression and potential function of bone morphogenetic proteins 2 and 4 in bovine trophectoderm

Author

Pennington Kathleen A and Ealy Alan D

Subjects
Paracrine factor, Placenta, Conceptus, Interferon-tau, Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Abstract Background Bone morphogenetic proteins (BMPs) were first described for their roles in bone formation, but they now also are known to possess additional activities, including those relating to embryogenesis. The objectives of this work were to 1) determine if peri-attachment bovine conceptuses and bovine trophoblast cells (CT1) contain transcripts for BMP2 and 4, an innate inhibitor noggin (NOG), and BMP2/4 receptors (BMPRII, ACVR1, BMPR1A, BMPR1B), and 2) determine if BMP2 or 4 supplementation to CT1 cells affects cell proliferation, differentiation or trophoblast-specific gene expression. Methods RNA was isolated from day 17 bovine conceptuses and CT1 cells. After RT-PCR, amplified products were cloned and sequenced. In other studies CT1 cells were treated with BMP2 or 4 at various concentrations and effects on cell viability, cell differentiation and abundance of IFNT and CSH1 mRNA were evaluated. Results Transcripts for BMP2 and 4 were detected in bovine conceptuses and CT1 cells. Also, transcripts for each BMP receptor were detected in conceptuses and CT1 cells. Transcripts for NOG were detected in conceptuses but not CT1 cells. Cell proliferation was reduced by BMP4 but not BMP2 supplementation. Both factors reduced IFNT mRNA abundance but had no effect on CSH1 mRNA abundance in CT1 cells. Conclusions The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment. BMP4 negatively impacts CT1 cell growth and both BMPs affect IFNT mRNA abundance.

Published
2012
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142. Preoperative Y-90 microsphere selective internal radiation treatment for tumor downsizing and future liver remnant recruitment: a novel approach to improving the safety of major hepatic resections

Author

Gulec Seza A, Pennington Kenneth, Hall Michael, and Fong Yuman

Subjects
Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Extended liver resections are being performed more liberally than ever. The extent of resection of liver metastases, however, is restricted by the volume of the future liver remnant (FLR). An intervention that would both accomplish tumor control and induce compensatory hypertrophy, with good patient tolerability, could improve clinical outcomes. Case presentation A 53-year-old woman with a history of cervical cancer presented with a large liver mass. Subsequent biopsy indicated poorly differentiated carcinoma with necrosis suggestive of squamous cell origin. A decision was made to proceed with pre-operative chemotherapy and Y-90 microsphere SIRT with the intent to obtain systemic control over the disease, downsize the hepatic lesion, and improve the FLR. A surgical exploration was performed six months after the first SIRT (three months after the second). There was no extrahepatic disease. The tumor was found to be significantly decreased in size with central and peripheral scarring. The left lobe was satisfactorily hypertrophied. A formal right hepatic lobectomy was performed with macroscopic negative margins. Conclusion Selective internal radiation treatment (SIRT) with yttrium-90 (Y-90) microspheres has emerged as an effective liver-directed therapy with a favorable therapeutic ratio. We present this case report to suggest that the portal vein radiation dose can be substantially increased with the intent of inducing portal/periportal fibrosis. Such a therapeutic manipulation in lobar Y-90 microsphere treatment could accomplish the end points of PVE with avoidance of the concern regarding tumor progression.

Published
2009
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145. 732P Durvalumab + carboplatin/paclitaxel (CP) followed by durvalumab ± olaparib as a first-line treatment for endometrial cancer (EC): Progression-free survival (PFS) by clinical factors in DUO-E.

Author

Blank, S.V., McCollum, M., Anderson, C., Pennington, K., Salinas, E., Richardson, D.L., Slomovitz, B.M., Kim, B-G., Liu, J., Mori, M., Guette, P.L. Ramos, Joseph de Pádua, C., Martinez-Garcia, J., Papadimitriou, C., Grisan, K., Póka, R.L., Kowgier, M., Del Rosario, P.M.D., Van Nieuwenhuysen, E., and Westin, S.

Subjects
*ENDOMETRIAL cancer, *PROGRESSION-free survival, *OLAPARIB, *PACLITAXEL, *CARBOPLATIN
Published
2024
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146. 731P Post-progression survival outcomes in patients (pts) with primary advanced or recurrent endometrial cancer (pA/rEC) in the ENGOT-EN6-NSGO/GOG-3031/RUBY trial who received follow-up immunotherapy.

Author

Mirza, M.R., Mathews, C., Gilbert, L., Bjorge, L., Ring, K., Pishchyk, M.M., Pennington, K., Segev, Y., Powell, M.A., Van Gorp, T., Bender, D., Schneider, K., Miller, R., Armstrong, A., Canturia, G., Gogoi, R., Antony, G., Stevens, S., Valabrega, G., and Landrum, L.M.

Subjects
*ENDOMETRIAL cancer, *SURVIVAL rate, *TREATMENT effectiveness, *IMMUNOTHERAPY
Published
2024
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