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1,097 results on '"Pastore, M"'

101. Mitochondrial oxidative metabolism contributes to maintain a cancer stem cell phenotype in cholangiocarcinoma

Author

Raggi, C., primary, Taddei, M.L., additional, Sacco, E., additional, Navari, N., additional, Correnti, M., additional, Piombanti, B., additional, Pastore, M., additional, Iorio, J., additional, Lori, G., additional, Peano, C., additional, Cibella, J., additional, Lewinska, M., additional, Andersen, J.B., additional, Di Maira, G., additional, Ramazzotti, M., additional, Orlandi, Ivan, additional, Chiarugi, P., additional, and Marra, F., additional

Published
2020
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106. 1227 Risk stratification of patients with asymptomatic moderate mitral regurgitation: the prognostic value of left atrial strain

Author

Cameli, M, primary, Pastore, M C, additional, Righini, F M, additional, Mandoli, G E, additional, D"ascenzi, F, additional, Lisi, M, additional, Nistor, D, additional, Sparla, S, additional, Curci, V, additional, Di Tommaso, C, additional, Marino, F, additional, Stricagnoli, M, additional, and Mondillo, S, additional

Published
2020
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112. Integrating interaural differences of time and level across frequencies and with each other in a precedence effect model

Author

Pastore, M. Torben and Braasch, Jonas

Abstract

Proceedings of the ICA 2019 and EAA Euroregio : 23rd International Congress on Acoustics, integrating 4th EAA Euroregio 2019 : 9-13 September 2019, Aachen, Germany / proceedings editor: Martin Ochmann, Michael Vorländer, Janina Fels 23rd International Congress on Acoustics, integrating 4th EAA Euroregio 2019, ICA 2019, Aachen, Germany, 9 Sep 2019 - 13 Sep 2019; Aachen (2019)., Published by Aachen

Published
2019
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119. Antitumor Activity of a Novel Fibroblast Growth Factor Receptor Inhibitor for Intrahepatic Cholangiocarcinoma

Author

Raggi, C, Fiaccadori, K, Pastore, M, Correnti, M, Piombanti, B, Forti, E, Navari, N, Abbadessa, G, Hall, T, Destro, A, Di Tommaso, L, Roncalli, M, Meng, F, Glaser, S, Rovida, E, Peraldo-Neia, C, Olaizola, P, Banales, J, Gerussi, A, Elvevi, A, Droz Dit Busset, M, Bhoori, S, Mazzaferro, V, Alpini, G, Marra, F, Invernizzi, P, Raggi, Chiara, Fiaccadori, Karim, Pastore, Mirella, Correnti, Margherita, Piombanti, Benedetta, Forti, Elisa, Navari, Nadia, Abbadessa, Giovanni, Hall, Terence, Destro, Annarita, Di Tommaso, Luca, Roncalli, Massimo, Meng, Fanyin, Glaser, Shannon, Rovida, Elisabetta, Peraldo-Neia, Caterina, Olaizola, Paula, Banales, Jesus M, Gerussi, Alessio, Elvevi, Alessandra, Droz Dit Busset, Michele, Bhoori, Sherrie, Mazzaferro, Vincenzo, Alpini, Gianfranco, Marra, Fabio, Invernizzi, Pietro, Raggi, C, Fiaccadori, K, Pastore, M, Correnti, M, Piombanti, B, Forti, E, Navari, N, Abbadessa, G, Hall, T, Destro, A, Di Tommaso, L, Roncalli, M, Meng, F, Glaser, S, Rovida, E, Peraldo-Neia, C, Olaizola, P, Banales, J, Gerussi, A, Elvevi, A, Droz Dit Busset, M, Bhoori, S, Mazzaferro, V, Alpini, G, Marra, F, Invernizzi, P, Raggi, Chiara, Fiaccadori, Karim, Pastore, Mirella, Correnti, Margherita, Piombanti, Benedetta, Forti, Elisa, Navari, Nadia, Abbadessa, Giovanni, Hall, Terence, Destro, Annarita, Di Tommaso, Luca, Roncalli, Massimo, Meng, Fanyin, Glaser, Shannon, Rovida, Elisabetta, Peraldo-Neia, Caterina, Olaizola, Paula, Banales, Jesus M, Gerussi, Alessio, Elvevi, Alessandra, Droz Dit Busset, Michele, Bhoori, Sherrie, Mazzaferro, Vincenzo, Alpini, Gianfranco, Marra, Fabio, and Invernizzi, Pietro

Abstract

Fibroblast growth factor receptor 2 (FGFR2) might have an important role in the pathogenesis and biology of cholangiocarcinoma (CCA). We examined FGFR expression in CCA tumor specimens obtained from patients and CCA cell lines, and then determined the effects of the novel FGFR inhibitor, derazantinib (DZB; formally, ARQ 087), which is currently in clinical phase 2 trials for intrahepatic CCA. DZB inhibited the growth of CCA cell lines in a dose-dependent manner, and extracellular signal-regulated kinase 1/2 and AKT. It also activated apoptotic and cell growth arrest signaling. DZB reduced the in vitro invasiveness and the expression of key epithelial-mesenchymal transition genes. The in vitro data correlated with the expression of FGFRs in human CCA specimens by immunohistochemistry (FGFR1, 30% positive; and FGFR2, 65% positive) and the CCA cell lines assayed by Western blot analysis. These correlated in vitro studies suggest that FGFR may play an important role in the pathogenesis and biology of CCA. Our findings support the notion that FGFR inhibitors, like DZB, should be further evaluated at the clinical stage as targeted therapy for CCA treatment.

Published
2019

120. ANTITUMOR ACTIVITY OF A NOVEL FGFR INHIBITOR IN INTRAHEPATIC CHOLANGIOCARCINOMA

Author

Raggi, C, Fiaccadori, K, Pastore, M, Correnti, M, Piombanti, B, Forti, E, Navari, N, Abbadessa, G, Hall, T, Destro, A, Di Tommaso, L, Roncalli, M, Meng, F, Glaser, S, Rovida, E, Peraldo-Neia, C, Olaizola, P, Banales, J, Gerussi, A, Elvevi, A, Busset, M, Bhoori, S, Mazzaferro, V, Alpini, G, Marra, F, Invernizzi, P, Glaser, SS, Banales, JM, Busset, MDD, Raggi, C, Fiaccadori, K, Pastore, M, Correnti, M, Piombanti, B, Forti, E, Navari, N, Abbadessa, G, Hall, T, Destro, A, Di Tommaso, L, Roncalli, M, Meng, F, Glaser, S, Rovida, E, Peraldo-Neia, C, Olaizola, P, Banales, J, Gerussi, A, Elvevi, A, Busset, M, Bhoori, S, Mazzaferro, V, Alpini, G, Marra, F, Invernizzi, P, Glaser, SS, Banales, JM, and Busset, MDD

Published
2019

123. The effect of temporal diffusion on the ongoing precedence effect.

Author

Pastore, M. Torben and Braasch, Jonas

Subjects
ACOUSTIC wave propagation, PRECEDENCE, DIFFUSION, HEADPHONES, LISTENING
Abstract

In room acoustic scenarios, listeners' localization is often dominated by the sound propagating directly from the its source despite numerous reflections that present different spatial cues only milliseconds later. This is called the precedence effect (PE). Most studies have simulated the PE by presenting one sound (the lead) followed by a copy of the lead that is delayed and presented with different interaural cues (the lag). These simulations assume that reflective surfaces are flat, yet interior surfaces are often far more complex and variable, resulting in spatially and temporally diffuse reflections. The effect of the temporal aspect of this diffusion on listeners' localization of lead/lag, 200-ms duration, noise stimuli filtered to 100-900 Hz and presented over headphones is investigated. Lag stimuli are convolved with a Hanning-windowed 2-ms noise burst to simulate temporal effects of uneven reflective surfaces. Results show that listeners' localization is dominated by the interaural cues of the lead, even when gating onsets/offsets are windowed out. Modeling analyses based on those in Pastore and Braasch 2019 suggest that interaural time differences in the ongoing stimulus portion can be extracted from rising slopes of the envelopes of neural output, even when lead and lag envelopes are decorrelated. [ABSTRACT FROM AUTHOR]

Published
2020
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124. Forming clusters of multiple sounds improves talker identification in an auditory scene.

Author

Yost, William A., Pastore, M. Torben, and Robinson, Phillip

Subjects
AUDITORY scene analysis, LISTENING, SOUNDS, CONSONANTS, ATTENTION
Abstract

In several recent papers we have shown that listeners perceive differences in the size of a small auditory scene (< 4 sources) for short-duration sounds (e.g., consonant-vowel, CV, pairs) presented at about the same time, but such differences are not perceived for larger scenes. Spatial separation of a small number of sound sources affects performance much more than spatially separating a larger number of sound sources. In this presentation, the number of sound sources is small, but not the number of sounds (CVs). For example, listeners are poor at determining if a target talker is the same as a cue talker, when the target is presented at one sound-source location and several distractor talkers are presented each at different sound-source locations. If all distractor talkers are "clustered (mixed)" at a single source spatially separated from the target sound source, then listeners are better at determining if the target talker was the same as the cue. Several additional scenarios were tested, all indicating that "clustering" sounds into a small number of sound sources improves target-talker identification compared to when sounds are presented from a larger number of sources. [ABSTRACT FROM AUTHOR]

Published
2020
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125. Time-dependent cognitive and somatic symptoms of depression as predictors of new cardiac-related events in at-risk patients: the UPBEAT-UK cohort.

Author

Norton, J., Pastore, M., Ancelin, M., Hotopf, M., Tylee, A., Mann, A., and Palacios, J.

Subjects
*DISEASE relapse, *HEART disease risk factors, *COGNITION disorders, *CONFIDENCE intervals, *RISK assessment, *MENTAL depression, *QUESTIONNAIRES, *SOMATOFORM disorders, *PROPORTIONAL hazards models, *DISEASE complications
Abstract

Background: Evidence suggests that somatic rather than cognitive depressive symptoms are risk factors for recurrent cardiac events in at-risk patients. However, this has never been explored using a time-dependent approach in a narrow time-frame, allowing a cardiac event-free time-window. Methods: The analysis was performed on 595 participants [70.6% male, median age 72 (27–98)] drawn from the UPBEAT-UK heart disease patient cohort with 6-monthly follow-ups over 3 years. Depressive symptomatology was measured using the Patient Health Questionnaire-9 (PHQ-9) (four somatic, five cognitive items). New cardiac events (NCEs) including cardiac-related mortality were identified by expert examination of patient records. Analyses were performed using Cox proportional hazard models with delayed entry, with time-dependent depressive dimensions and covariates measured 12–18 months (median: 14.1, IQR: 3.5) prior to the event, with a 12-month cardiac event-free gap. Results: There were 95 NCEs during the follow-up [median time-to-event from baseline: 22.3 months (IQR: 13.4)]. Both the somatic (HR 1.12, 95% CI 1.05–1.20, p = 0.001) and cognitive dimensions (HR 1.11, 95% CI 1.03–1.18, p = 0.004) were time-dependent risk factors for an NCE in the multi-adjusted models. Specific symptoms (poor appetite/overeating for the somatic dimension, hopelessness and feeling like a failure for the cognitive dimension) were also significantly associated. Conclusion: This is the first study of the association between depressive symptom dimensions and NCEs in at-risk patients using a time-to-event standardised approach. Both dimensions considered apart were independent predictors of an NCE, along with specific items, suggesting regular assessments and tailored interventions targeting specific depressive symptoms may help to prevent NCEs in at-risk populations. [ABSTRACT FROM AUTHOR]

Published
2021
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127. Sound-source localization when listeners and sound sources rotate: The Auditory Filehne Illusion.

Author

Yost, William A. and Pastore, M. T.

Subjects
ACOUSTIC localization, SOUND, ROTATIONAL motion, VISUALIZATION, DEAFNESS
Abstract

Freeman et al. (J. Exp. Psych.: Hum. Percept. Perform., 2017) demonstrated an auditory analog to the visual Filehne Illusion. For the auditory Filehne Illusion, a stationary sound source is often perceived as rotating in the opposite direction of head rotation, i.e., in a head-centric direction based on the changing auditory-spatial cues due to head rotation. We investigated conditions like the auditory Filehne Illusion for a variety of stimulus and rotation conditions to gain additional insights into how head-position information might compensate for head-centric information (derived from the auditory-spatial cues) to form world-centric, sound-source localization estimates. [ABSTRACT FROM AUTHOR]

Published
2019
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128. Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation

Author

Campa, D. Pastore, M. Capurso, G. Hackert, T. Di Leo, M. Izbicki, J.R. Khaw, K.-T. Gioffreda, D. Kupcinskas, J. Pasquali, C. Macinga, P. Kaaks, R. Stigliano, S. Peeters, P.H. Key, T.J. Talar-Wojnarowska, R. Vodicka, P. Valente, R. Vashist, Y.K. Salvia, R. Papaconstantinou, I. Shimizu, Y. Valsuani, C. Zambon, C.F. Gazouli, M. Valantiene, I. Niesen, W. Mohelnikova-Duchonova, B. Hara, K. Soucek, P. Malecka-Panas, E. Bueno-de-Mesquita, H.B. Johnson, T. Brenner, H. Tavano, F. Fogar, P. Ito, H. Sperti, C. Butterbach, K. Latiano, A. Andriulli, A. Cavestro, G.M. Busch, O.R.C. Dijk, F. Greenhalf, W. Matsuo, K. Lombardo, C. Strobel, O. König, A.-K. Cuk, K. Strothmann, H. Katzke, V. Cantore, M. Mambrini, A. Oliverius, M. Pezzilli, R. Landi, S. Canzian, F.

Subjects
endocrine system diseases, digestive system diseases
Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a very aggressive tumor with a five-year survival of less than 6%. Chronic pancreatitis (CP), an inflammatory process in of the pancreas, is a strong risk factor for PDAC. Several genetic polymorphisms have been discovered as susceptibility loci for both CP and PDAC. Since CP and PDAC share a consistent number of epidemiologic risk factors, the aim of this study was to investigate whether specific CP risk loci also contribute to PDAC susceptibility. We selected five common SNPs (rs11988997, rs379742, rs10273639, rs2995271 and rs12688220) that were identified as susceptibility markers for CP and analyzed them in 2,914 PDAC cases, 356 CP cases and 5,596 controls retrospectively collected in the context of the international PANDoRA consortium. We found a weak association between the minor allele of the PRSS1-PRSS2-rs10273639 and an increased risk of developing PDAC (ORhomozygous = 1.19, 95% CI 1.02–1.38, p = 0.023). Additionally all the SNPs confirmed statistically significant associations with risk of developing CP, the strongest being PRSS1-PRSS2-rs10273639 (ORheterozygous = 0.51, 95% CI 0.39–0.67, p = 1.10 × 10−6) and MORC4-rs 12837024 (ORhomozygous = 2.07 (1.55–2.77, ptrend = 0.7 × 10−11). Taken together, the results from our study do not support variants rs11988997, rs379742, rs10273639, rs2995271 and rs12688220 as strong predictors of PDAC risk, but further support the role of these SNPs in CP susceptibility. Our study suggests that CP and PDAC probably do not share genetic susceptibility, at least in terms of high frequency variants. © 2017 UICC

Published
2018

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