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110 results on '"Pasqualini, Leonella"'

101. Transcutaneous Oxygen Tension Behavior in the Different Stages of Peripheral Vascular Disease and Its Correlation With Ankle/Arm Pressure Ratio and Calf Blood Flow.

Author

Mannarino, Elmo, Maragoni, Giorgio, Pasqualini, Leonella, Sanchini, Roberto, Rossi, Pietro, and Orlandi, Ugo

Subjects
PERIPHERAL vascular disease diagnosis, PERIPHERAL vascular diseases, BLOOD circulation disorders, VASCULAR disease diagnosis, DIAGNOSIS
Abstract

The practical utility of transcutaneous oxygen tension (TcPO2) has been evaluated in 22 normal subjects and in 54 patients suffering from peripheral vascular disease (PVD) at various stages (II, III, IV), to define its clinical use in the diagnosis of PVD. Basal TcPO2 values can distinguish normal subjects only from stages m and IV PVD patients. In the case of stage n PVD patients the evaluation of the half-recovery time of TcPO2 basal values after an induced ischemia of the limb is mandatory. The study also showed that there are no significant statistical correlations among the TcPO2 values, Doppler, and plethysmographic parameters. [ABSTRACT FROM AUTHOR]

Published
1987
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102. Prostaglandin E1Improves Endothelial Function in Critical Limb Ischemia

Author

Marchesi, Simona, Pasqualini, Leonella, Lombardini, Rita, Vaudo, Gaetano, Lupattelli, Graziana, Pirro, Matteo, Schillaci, Giuseppe, and Mannarino, Elmo

Abstract

Prostaglandin E1(PGE1) may relieve rest pain and heal ulcers in critical limb ischemia, but its mechanism of action is still incompletely understood. To investigate the effects of PGE1treatment on endothelial function evaluated as brachial artery flow-mediated vasodilation (FMV) and on soluble adhesion molecule plasma levels (vascular adhesion molecule-1 sVCAM-1 and intercellular adhesion molecule-1 sICAM-1), 12 patients with critical limb ischemia were treated with daily PGE1IV infusion (alprostadil 60 g) for 2 weeks. FMV and plasma sICAM-1 and sVCAM-1 concentrations were determined at baseline, after the first infusion, and after 1 and 2 weeks. Compared with 30 healthy control subjects, patients had higher baseline sVCAM-1 (2.402 ± 296 ng/ml vs 972 ± 117 ng/ml) and sICAM-1 levels (464 ± 51 ng/ml vs 206 ± 37 ng/ml, both p < 0.05) and lower FMV (1.0 ± 1.1 vs 5.6 ± 1.6, p < 0.05). sICAM-1 concentration progressively decreased with treatment (from 464 ± 51 ng/ml to 326 ± 56 ng/ml, 288 ± 42 ng/ml, and 279 ± 44 ng/ml after the first dose and, respectively, after 1 and 2 weeks; all p < 0.05). sVCAM-1 showed a reduction after 2 weeks (from 2.402 ± 296 ng/ml to 1.916 ± 176 ng/ml; p < 0.05). FMV improved after 1 and 2 weeks (from 1.0 ± 1.1 to 3.1 ± 0.6 and 5.2 ± 2.1, both p < 0.05). In conclusion, treatment with PGE1determines a significant improvement in endothelial function in patients with critical limb ischemia.

Published
2003

110. The influence of iloprost on blood rheology and tissue perfusion in patients with intermittent claudication.

Author

Ciuffetti G, Sokola E, Lombardini R, Pasqualini L, Pirro M, and Mannarino E

Subjects
Blood Viscosity drug effects, Double-Blind Method, Exercise Test, Humans, Male, Microcirculation drug effects, Middle Aged, Treatment Outcome, Hemorheology drug effects, Iloprost therapeutic use, Intermittent Claudication drug therapy, Peripheral Vascular Diseases drug therapy, Platelet Aggregation Inhibitors therapeutic use, Vasodilator Agents therapeutic use
Abstract

Background: In peripheral vascular disease (PVD), impaired blood viscosity (BV) plays a major role in residual microvascular perfusion. Indeed, during acute leg ischaemia factors influencing microvascular BV include the plasma fibrinogen concentration, red and white blood cell rheology, as well as platelet aggregation and activation., Aim: To assess the effects of Iloprost in patients with PVD., Methods: The effects of an infusion of a single dose of Iloprost (from 0.5 up to a maximum of 2 ng/kg/min. over 6 hours) in 16 patients with stage II peripheral vascular disease on blood rheology and tissue perfusion were determined in a double-blind placebo-controlled study, using repeated treadmill exercise test to stress leg circulation. Blood viscosity at low shear, soluble P-selectin levels (expression of platelet activation), unfractionated leukocyte and erythrocyte filterability rates, plasma fibrinogen concentration, haematocrit, leukocyte and platelet counts and transcutaneous oxygen pressure (TcPO(2)) were measured in two matched groups of 8 PVD patients before and after Iloprost infusion., Results: Controlled peripheral ischaemia generated an impaired haemorheological profile; Iloprost reduced the impairments in BV and the filterability rates of unfractionated leukocytes and erythrocytes, inhibited platelet activation, and improved erythrocyte deformability. These changes were associated with significant shortening of the TcPO(2) half recovery time (the drop of TcPO(2) occurs because the ischaemic skeletal muscle steals oxygen from the skin), indicating that ischaemic damage had been contained., Conclusions: Our results show that the infusion of a single dose of Iloprost in patients with PVD is associated with a significant improvement in microvascular functioning

Published
2003

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