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475 results on '"Park, Susanna S."'

110. Intravitreal Administration of Human Bone Marrow CD34+ Stem Cells in a Murine Model of Retinal Degeneration.

Author

Moisseiev, Elad, Moisseiev, Elad, Smit-McBride, Zeljka, Oltjen, Sharon, Zhang, Pengfei, Zawadzki, Robert J, Motta, Monica, Murphy, Christopher J, Cary, Whitney, Annett, Geralyn, Nolta, Jan A, Park, Susanna S, Moisseiev, Elad, Moisseiev, Elad, Smit-McBride, Zeljka, Oltjen, Sharon, Zhang, Pengfei, Zawadzki, Robert J, Motta, Monica, Murphy, Christopher J, Cary, Whitney, Annett, Geralyn, Nolta, Jan A, and Park, Susanna S

Abstract

PurposeIntravitreal murine lineage-negative bone marrow (BM) hematopoietic cells slow down retinal degeneration. Because human BM CD34+ hematopoietic cells are not precisely comparable to murine cells, this study examined the effect of intravitreal human BM CD34+ cells on the degenerating retina using a murine model.MethodsC3H/HeJrd1/rd1 mice, immunosuppressed systemically with tacrolimus and rapamycin, were injected intravitreally with PBS (n = 16) or CD34+ cells (n = 16) isolated from human BM using a magnetic cell sorter and labeled with enhanced green fluorescent protein (EGFP). After 1 and 4 weeks, the injected eyes were imaged with scanning laser ophthalmoscopy (SLO)/optical coherence tomography (OCT) and tested with electroretinography (ERG). Eyes were harvested after euthanasia for immunohistochemical and microarray analysis of the retina.ResultsIn vivo SLO fundus imaging visualized EGFP-labeled cells within the eyes following intravitreal injection. Simultaneous OCT analysis localized the EGFP-labeled cells on the retinal surface resulting in a saw-toothed appearance. Immunohistochemical analysis of the retina identified EGFP-labeled cells on the retinal surface and adjacent to ganglion cells. Electroretinography testing showed a flat signal both at 1 and 4 weeks following injection in all eyes. Microarray analysis of the retina following cell injection showed altered expression of more than 300 mouse genes, predominantly those regulating photoreceptor function and maintenance and apoptosis.ConclusionsIntravitreal human BM CD34+ cells rapidly home to the degenerating retinal surface. Although a functional benefit of this cell therapy was not seen on ERG in this rapidly progressive retinal degeneration model, molecular changes in the retina associated with CD34+ cell therapy suggest potential trophic regenerative effects that warrant further exploration.

Published
2016

115. Phase-Contrast Optical Coherence Tomography: A New Technique for Non-Invasive Angiography

Author

Schwartz, Daniel M., Fingler, Jeff, Kim, Dae Yu, Zawadzki, Robert J., Morse, Lawrence S., Park, Susanna S., Fraser, Scott E., and Werner, John S.

Subjects
Adult, Aged, 80 and over, Male, Diabetic Retinopathy, Choroid, Retinal Vessels, Middle Aged, Article, Choroidal Neovascularization, Geographic Atrophy, Wet Macular Degeneration, Humans, Female, Fluorescein Angiography, Tomography, Optical Coherence
Abstract

Phase-variance optical coherence tomography (PV-OCT) provides volumetric imaging of the retinal vasculature without the need for intravenous injection of a fluorophore. We compare images from PV-OCT and fluorescein angiography (FA) for normal individuals and patients with age-related macular degeneration (AMD) and diabetic retinopathy.This is an evaluation of a diagnostic technology.Four patients underwent comparative retinovascular imaging using FA and PV-OCT. Imaging was performed on 1 normal individual, 1 patient with dry AMD, 1 patient with exudative AMD, and 1 patient with nonproliferative diabetic retinopathy.Fluorescein angiography imaging was performed using a Topcon Corp (Tokyo, Japan) (TRC-50IX) camera with a resolution of 1280 (H) × 1024 (V) pixels. The PV-OCT images were generated by software data processing of the entire cross-sectional image from consecutively acquired B-scans. Bulk axial motion was calculated and corrected for each transverse location, reducing the phase noise introduced from eye motion. Phase variance was calculated through the variance of the motion-corrected phase changes acquired within multiple B-scans at the same position. Repeating these calculations over the entire volumetric scan produced a 3-dimensional PV-OCT representation of the vasculature.Feasibility of rendering retinal and choroidal microvasculature using PV-OCT was compared qualitatively with FA, the current gold standard for retinovascular imaging.Phase-variance OCT noninvasively rendered a 2-dimensional depth color-coded vasculature map of the retinal and choroidal vasculature. The choriocapillaris was imaged with better resolution of microvascular detail using PV-OCT. Areas of geographic atrophy and choroidal neovascularization imaged by FA were depicted by PV-OCT. Regions of capillary nonperfusion from diabetic retinopathy were shown by both imaging techniques; there was not complete correspondence between microaneurysms shown on FA and PV-OCT images.Phase-variance OCT yields high-resolution imaging of the retinal and choroidal microvasculature that compares favorably with FA.

Published
2013

116. Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography

Author

McClintic,Scott, Kim,Dae Yu, Fingler,Jeff, Garcia,Susan, Zawadzki,Robert J, Morse,Lawrence S, Park,Susanna S, Fraser,Scott E, Werner,John S, Ruggiero,Jason P, Schwartz,Daniel M, McClintic,Scott, Kim,Dae Yu, Fingler,Jeff, Garcia,Susan, Zawadzki,Robert J, Morse,Lawrence S, Park,Susanna S, Fraser,Scott E, Werner,John S, Ruggiero,Jason P, and Schwartz,Daniel M

Abstract

Scott M McClintic,1 Dae Yu Kim,2 Jeff Fingler,3 Susan Garcia,4 Robert J Zawadzki,4 Lawrence S Morse,4 Susanna S Park,4 Scott E Fraser,3 John S Werner,4 Jason P Ruggiero,5 Daniel M Schwartz6 1Department of Ophthalmology, Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA; 2Beckman Laser Institute Korea and Department of Biomedical Engineering, Dankook University, Cheonan, South Korea; 3Translational Imaging Center, University of Southern California, Los Angeles, CA, 4Department of Ophthalmology and Vision Science, University of California Davis, Sacramento, CA, 5Retina Associates, PC, Winchester, VA, 6Department of Ophthalmology and Vision Science, University of California San Francisco, San Francisco, CA, USA Purpose: To demonstrate the use of phase-variance optical coherence tomography (PV-OCT) angiography for detection of pigment epithelial detachment (PED) vascularization in age-related macular degeneration (AMD). Patients and methods: Patients with PEDs and exudative AMD were evaluated by the Retina Services at the University of California, Davis, and the University of California, San Francisco. Each subject underwent fluorescein angiography and structural optical coherence tomography (OCT). Phase-variance OCT analysis was used to create angiographic images of the retinal and choroidal vasculature. PV-OCT-generated B-scans were superimposed on structural OCT B-scans to allow easy identification of perfused vascular structures. Results: Three patients with vascularized PEDs were imaged with PV-OCT, and each was found to have a vascular signal extending from the choroid into the hyperreflective substance of the PED. Two patients who had no evidence of PED vascularization on fluorescein angiography did not have vascular signals within their PEDs on PV-OCT. Conclusion: Structural OCT and PV-OCT images can be combined to create composite B-scans that offer high-resolution views of the retinal tissue along with dynamic vascular visualization.

Published
2015

117. Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials

Author

Willoughby, Alex S., primary, Ying, Gui-shuang, additional, Toth, Cynthia A., additional, Maguire, Maureen G., additional, Burns, Russell E., additional, Grunwald, Juan E., additional, Daniel, Ebenezer, additional, Jaffe, Glenn J., additional, Williams, David F., additional, Beardsley, Sara, additional, Bennett, Steven, additional, Cantrill, Herbert, additional, Chan-Tram, Carmen, additional, Cheshier, Holly, additional, Damato, Kathyrn, additional, Davies, John, additional, Dev, Sundeep, additional, Enloe, Julianne, additional, Follano, Gennaro, additional, Gilbert, Peggy, additional, Johnson, Jill, additional, Jones, Tori, additional, Mayleben, Lisa, additional, Mittra, Robert, additional, Moos, Martha, additional, Neist, Ryan, additional, Oestreich, Neal, additional, Quiram, Polly, additional, Ramsay, Robert, additional, Ryan, Edwin, additional, Schindeldecker, Stephanie, additional, Snater, John, additional, Steele, Trenise, additional, Selders, Dwight, additional, Tonsfeldt, Jessica, additional, Valardi, Shelly, additional, Fish, Gary Edd, additional, Aguado, Hank A., additional, Arceneaux, Sally, additional, Arnwine, Jean, additional, Bell, Kim, additional, Bell, Tina, additional, Boleman, Bob, additional, Bradley, Patricia, additional, Callanan, David, additional, Coors, Lori, additional, Creighton, Jodi, additional, Crew, Timothy, additional, Cummings, Kimberly, additional, Dock, Christopher, additional, Duignan, Karen, additional, Fuller, Dwain, additional, Gray, Keith, additional, Hendrix, Betsy, additional, Hesse, Nicholas, additional, Jaramillo, Diana, additional, Jost, Bradley, additional, Lash, Sandy, additional, Lonsdale, Laura, additional, Mackens, Michael, additional, Mutz, Karin, additional, Potts, Michael, additional, Sanchez, Brenda, additional, Snyder, William, additional, Solley, Wayne, additional, Tarter, Carrie, additional, Wang, Robert, additional, Williams, Patrick, additional, Perkins, Stephen L., additional, Anderson, Nicholas, additional, Arnold, Ann, additional, Blais, Paul, additional, Googe, Joseph, additional, Higdon, Tina T., additional, Hunt, Cecile, additional, Johnson, Mary, additional, Miller, James, additional, Moore, Misty, additional, Morris, Charity K., additional, Morris, Christopher, additional, Oelrich, Sarah, additional, Oliver, Kristina, additional, Seitz, Vicky, additional, Whetstone, Jerry, additional, Doft, Bernard H., additional, Bedel, Jay, additional, Bergren, Robert, additional, Borthwick, Ann, additional, Conrad, Paul, additional, Fec, Amanda, additional, Fulwylie, Christina, additional, Ingram, Willia, additional, Latham, Shawnique, additional, Lester, Gina, additional, Liu, Judy, additional, Lobes, Louis, additional, Lucko, Nicole M., additional, Mechling, Holly, additional, Merlotti, Lori, additional, McBroom, Keith, additional, Olsen, Karl, additional, Puskas, Danielle, additional, Rath, Pamela, additional, Schmucker, Maria, additional, Schueckler, Lynn, additional, Schultz, Christina, additional, Shultz, Heather, additional, Steinberg, David, additional, Vyas, Avni, additional, Whale, Kim, additional, Yeckel, Kimberly, additional, Orth, David H., additional, Arredondo, Linda S., additional, Brown, Susan, additional, Ciscato, Barbara J., additional, Civantos, Joseph M., additional, Figliulo, Celeste, additional, Hasan, Sohail, additional, Kosinski, Belinda, additional, Muir, Dan, additional, Nelson, Kiersten, additional, Packo, Kirk, additional, Pollack, John S., additional, Rezaei, Kourous, additional, Shelton, Gina, additional, Townsend-Patrick, Shannya, additional, Walsh, Marian, additional, Richard McDonald, H., additional, Ansari, Nina, additional, Bye, Amanda, additional, Fu, Arthur D., additional, Grout, Sean, additional, Indermill, Chad, additional, Johnson, Robert N., additional, Michael Jumper, J., additional, Linares, Silvia, additional, Lujan, Brandon J., additional, Munden, Ames, additional, Persons, Meredith, additional, Rodriguez, Rosa, additional, Rose, Jennifer M., additional, Teske, Brandi, additional, Urias, Yesmin, additional, Young, Stephen, additional, Dreyer, Richard F., additional, Daniel, Howard, additional, Connaughton, Michele, additional, Handelman, Irvin, additional, Hobbs, Stephen, additional, Hoerner, Christine, additional, Hudson, Dawn, additional, Kopfer, Marcia, additional, Lee, Michael, additional, Lemley, Craig, additional, Logan, Joe, additional, Ma, Colin, additional, Mallet, Christophe, additional, Milliron, Amanda, additional, Peters, Mark, additional, Wohlsein, Harry, additional, Pearlman, Joel A., additional, Andrews, Margo, additional, Bartlett, Melissa, additional, Carlson, Nanette, additional, Cox, Emily, additional, Equi, Robert, additional, Gonzalez, Marta, additional, Griffin, Sophia, additional, Hogue, Fran, additional, Kennedy, Lance, additional, Kryuchkov, Lana, additional, Lopez, Carmen, additional, Lopez, Danny, additional, Luevano, Bertha, additional, McKenna, Erin, additional, Patel, Arun, additional, Reed, Brian, additional, Secor, Nyla, additional, Sison, Iris R., additional, Tsai, Tony, additional, Varghis, Nina, additional, Waller, Brooke, additional, Wendel, Robert, additional, Yebra, Reina, additional, Roth, Daniel B., additional, Deinzer, Jane, additional, Fine, Howard, additional, Green, Flory, additional, Green, Stuart, additional, Keyser, Bruce, additional, Leff, Steven, additional, Leviton, Amy, additional, Martir, Amy, additional, Mosenthine, Kristin, additional, Muscle, Starr, additional, Okoren, Linda, additional, Parker, Sandy, additional, Prenner, Jonathan, additional, Price, Nancy, additional, Rogers, Deana, additional, Rosas, Linda, additional, Schlosser, Alex, additional, Studenko, Loretta, additional, Tantum, Thea, additional, Wheatley, Harold, additional, Trese, Michael T., additional, Aaberg, Thomas, additional, Bezaire, Denis, additional, Bridges, Craig, additional, Bryant, Doug, additional, Capone, Antonio, additional, Coleman, Michelle, additional, Consolo, Christina, additional, Cook, Cindy, additional, DuLong, Candice, additional, Garretson, Bruce, additional, Grooten, Tracy, additional, Hammersley, Julie, additional, Hassan, Tarek, additional, Jessick, Heather, additional, Jones, Nanette, additional, Kinsman, Crystal, additional, Krumlauf, Jennifer, additional, Lewis, Sandy, additional, Locke, Heather, additional, Margherio, Alan, additional, Markus, Debra, additional, Marsh, Tanya, additional, Neal, Serena, additional, Noffke, Amy, additional, Oh, Kean, additional, Pence, Clarence, additional, Preston, Lisa, additional, Raphaelian, Paul, additional, Regan, Virginia R., additional, Roberts, Peter, additional, Ruby, Alan, additional, Sarrafizadeh, Ramin, additional, Scherf, Marissa, additional, Scott, Sarita, additional, Sneed, Scott, additional, Staples, Lisa, additional, Terry, Brad, additional, Trese, Matthew T., additional, Videtich, Joan, additional, Williams, George, additional, Zajechowski, Mary, additional, Joseph, Daniel P., additional, Blinder, Kevin, additional, Boyd, Lynda, additional, Buckley, Sarah, additional, Crow, Meaghan, additional, Dinatale, Amanda, additional, Engelbrecht, Nicholas, additional, Forke, Bridget, additional, Gabel, Dana, additional, Grand, Gilbert, additional, Grillion-Cerone, Jennifer, additional, Holekamp, Nancy, additional, Kelly, Charlotte, additional, Nobel, Ginny, additional, Pepple, Kelly, additional, Raeber, Matt, additional, Kumar Rao, P., additional, Ressel, Tammy, additional, Schremp, Steven, additional, Sgorlon, Merrilee, additional, Shears, Shantia, additional, Thomas, Matthew, additional, Timma, Cathy, additional, Vaughn, Annette, additional, Walters, Carolyn, additional, Weeks, Rhonda, additional, Wehmeier, Jarrod, additional, Wright, Tim, additional, Berinstein, Daniel M., additional, Ayyad, Aida, additional, Barazi, Mohammed K., additional, Bickhart, Erica, additional, Brady, Tracey, additional, Byank, Lisa, additional, Cronise, Alysia, additional, Denny, Vanessa, additional, Dunn, Courtney, additional, Flory, Michael, additional, Frantz, Robert, additional, Garfinkel, Richard A., additional, Gilbert, William, additional, Lai, Michael M., additional, Melamud, Alexander, additional, Newgen, Janine, additional, Newton, Shamekia, additional, Oliver, Debbie, additional, Osman, Michael, additional, Sanders, Reginald, additional, von Fricken, Manfred, additional, Dugel, Pravin, additional, Arenas, Sandra, additional, Balea, Gabe, additional, Bartoli, Dayna, additional, Bucci, John, additional, Cornelius, Jennifer A., additional, Dickens, Scheleen, additional, Doherty, Don, additional, Dunlap, Heather, additional, Goldenberg, David, additional, Jamal, Karim, additional, Jimenez, Norma, additional, Kavanagh, Nicole, additional, Kunimoto, Derek, additional, Martin, John, additional, Miner, Jessica, additional, Mobley, Sarah, additional, Park, Donald, additional, Quinlan, Edward, additional, Sipperley, Jack, additional, Slagle, Carol, additional, Smith, Danielle, additional, Yafchak, Miguelina, additional, Yager, Rohana, additional, Flaxel, Christina J., additional, Bailey, Steven, additional, Francis, Peter, additional, Howell, Chris, additional, Hwang, Thomas, additional, Ira, Shirley, additional, Klein, Michael, additional, Lauer, Andreas, additional, Liesegang, Teresa, additional, Lundquist, Ann, additional, Nolte, Sarah, additional, Nolte, Susan K., additional, Pickell, Scott, additional, Pope, Susan, additional, Rossi, Joseph, additional, Schain, Mitchell, additional, Steinkamp, Peter, additional, Toomey, Maureen D., additional, Vahrenwald, Debora, additional, West, Kelly, additional, Hubbard, Baker, additional, Andelman, Stacey, additional, Bergstrom, Chris, additional, Brower, Judy, additional, Cribbs, Blaine, additional, Curtis, Linda, additional, Dobbs, Jannah, additional, DuBois, Lindreth, additional, Gaultney, Jessica, additional, Gibbs, Deborah, additional, Jordan, Debora, additional, Leef, Donna, additional, Martin, Daniel F., additional, Myles, Robert, additional, Olsen, Timothy, additional, Schwent, Bryan, additional, Srivastava, Sunil, additional, Waldron, Rhonda, additional, Antoszyk, Andrew N., additional, Balasubramaniam, Uma, additional, Brooks, Danielle, additional, Brown, Justin, additional, Browning, David, additional, Clark, Loraine, additional, Ennis, Sarah, additional, Held, Susannah, additional, Helms, Jennifer V., additional, Herby, Jenna, additional, Karow, Angie, additional, Leotaud, Pearl, additional, Massimino, Caterina, additional, McClain, Donna, additional, McOwen, Michael, additional, Mindel, Jennifer, additional, Pereira, Candace, additional, Pierce, Rachel, additional, Powers, Michele, additional, Price, Angela, additional, Rohrer, Jason, additional, Sanders, Jason, additional, Avery, Robert L., additional, Avery, Kelly, additional, Basefsky, Jessica, additional, Beckner, Liz, additional, Castellarin, Alessandro, additional, Couvillion, Stephen, additional, Giust, Jack, additional, Giust, Matthew, additional, Nasir, Maan, additional, Pieramici, Dante, additional, Rabena, Melvin, additional, Risard, Sarah, additional, See, Robert, additional, Smith, Jerry, additional, Wan, Lisha, additional, Bakri, Sophie J., additional, Abu-Yaghi, Nakhleh, additional, Barkmeier, Andrew, additional, Berg, Karin, additional, Burrington, Jean, additional, Edwards, Albert, additional, Goddard, Shannon, additional, Howard, Shannon, additional, Iezzi, Raymond, additional, Lewison, Denise, additional, Link, Thomas, additional, McCannel, Colin A., additional, Overend, Joan, additional, Pach, John, additional, Ruszczyk, Margaret, additional, Shultz, Ryan, additional, Stephan, Cindy, additional, Vogen, Diane, additional, Bradford, Reagan H., additional, Bergman, Vanessa, additional, Burris, Russ, additional, Butt, Amanda, additional, Daniels, Beth, additional, Dwiggins, Connie, additional, Fransen, Stephen, additional, Guerrero, Tiffany, additional, Haivala, Darin, additional, Harris, Amy, additional, Icks, Sonny, additional, Kingsley, Ronald, additional, Redden, Lena, additional, Richmond, Rob, additional, Ross, Brittany, additional, White, Kammerin, additional, Youngberg, Misty, additional, Topping, Trexler M., additional, Bennett, Steve, additional, Chong, Sandy, additional, Ciotti, Mary, additional, Cleary, Tina, additional, Corey, Emily, additional, Donovan, Dennis, additional, Frederick, Albert, additional, Freese, Lesley, additional, Graham, Margaret, additional, Gud, Natalya, additional, Howard, Taneika, additional, Jones, Mike, additional, Morley, Michael, additional, Moses, Katie, additional, Stone, Jen, additional, Ty, Robin, additional, Wiegand, Torsten, additional, Williams, Lindsey, additional, Winder, Beth, additional, Awh, Carl C., additional, Amonette, Michelle, additional, Arrindell, Everton, additional, Beck, Dena, additional, Busbee, Brandon, additional, Dilback, Amy, additional, Downs, Sara, additional, Guidry, Allison, additional, Gutow, Gary, additional, Hardin, Jackey, additional, Hines, Sarah, additional, Hutchins, Emily, additional, LaCivita, Kim, additional, Lester, Ashley, additional, Malott, Larry, additional, McCain, MaryAnn, additional, Miracle, Jayme, additional, Moffat, Kenneth, additional, Palazzotta, Lacy, additional, Robinson, Kelly, additional, Sonkin, Peter, additional, Travis, Alecia, additional, Wallace, Roy Trent, additional, Winters, Kelly J., additional, Wray, Julia, additional, Harris, April E., additional, Bunnell, Mari, additional, Crooks, Katrina, additional, Fitzgerald, Rebecca, additional, Javid, Cameron, additional, Kew, Corin, additional, Kill, Erica, additional, Kline, Patricia, additional, Kreienkamp, Janet, additional, Martinez, Maricruz, additional, Ann Moore, Roy, additional, Saavedra, Egbert, additional, Taylor, LuAnne, additional, Walsh, Mark, additional, Wilson, Larry, additional, Ciulla, Thomas A., additional, Coyle, Ellen, additional, Harrington, Tonya, additional, Harris, Charlotte, additional, Hood, Cindi, additional, Kerr, Ingrid, additional, Maturi, Raj, additional, Moore, Dawn, additional, Morrow, Stephanie, additional, Savage, Jennifer, additional, Sink, Bethany, additional, Steele, Tom, additional, Thukral, Neelam, additional, Wilburn, Janet, additional, Walker, Joseph P., additional, Banks, Jennifer, additional, Ciampaglia, Debbie, additional, Dyshanowitz, Danielle, additional, Frederick, Jennifer, additional, Tom Ghuman, A., additional, Grodin, Richard, additional, Kiesel, Cheryl, additional, Knips, Eileen, additional, McCue, Jonathan, additional, Ortiz, Maria, additional, Peters, Crystal, additional, Raskauskas, Paul, additional, Schoeman, Etienne, additional, Sharma, Ashish, additional, Wing, Glenn, additional, Youngblood, Rebecca, additional, Chandra, Suresh R., additional, Altaweel, Michael, additional, Blodi, Barbara, additional, Burke, Kathryn, additional, Dietzman, Kristine A., additional, Gottlieb, Justin, additional, Knutson, Gene, additional, Krolnik, Denise, additional, Michael Nork, T., additional, Olson, Shelly, additional, Peterson, John, additional, Reed, Sandra, additional, Soderling, Barbara, additional, Somers, Guy, additional, Stevens, Thomas, additional, Wealti, Angela, additional, Bearelly, Srilaxmi, additional, Branchaud, Brenda, additional, Bryant, Joyce W., additional, Crowell, Sara, additional, Fekrat, Sharon, additional, Gammage, Merritt, additional, Harrison, Cheala, additional, Jones, Sarah, additional, McClain, Noreen, additional, McCuen, Brooks, additional, Mruthyunjaya, Prithvi, additional, Queen, Jeanne, additional, Sarin, Neeru, additional, Skalak, Cindy, additional, Skelly, Marriner, additional, Suner, Ivan, additional, Tomany, Ronnie, additional, Welch, Lauren, additional, Park, Susanna S., additional, Cassidy, Allison, additional, Chandra, Karishma, additional, Good, Idalew, additional, Imson, Katrina, additional, Kaur, Sashi, additional, Metzler, Helen, additional, Morse, Lawrence, additional, Redenbo, Ellen, additional, Salvador, Marisa, additional, Telander, David, additional, Thomas, Mark, additional, Wallace, Cindy, additional, Barr, Charles C., additional, Battcher, Amanda, additional, Bottorff, Michelle, additional, Chasteen, Mary, additional, Clark, Kelly, additional, Denning, Diane, additional, Schoen, Debra, additional, Schultz, Amy, additional, Tempel, Evie, additional, Wheeler, Lisa, additional, Whittington, Greg K., additional, Stone, Thomas W., additional, Blevins, Todd, additional, Buck, Michelle, additional, Cruz, Lynn, additional, Heath, Wanda, additional, Holcomb, Diana, additional, Isernhagen, Rick, additional, Kidd, Terri, additional, Kitchens, John, additional, Sears, Cathy, additional, Slade, Ed, additional, Van Arsdall, Jeanne, additional, VanHoose, Brenda, additional, Wolfe, Jenny, additional, Wood, William, additional, Zilis, John, additional, Crooks, Carol, additional, Disney, Larry, additional, Liu, Mimi, additional, Petty, Stephen, additional, Sall, Sandra, additional, Folk, James C., additional, Aly, Tracy, additional, Brotherton, Abby, additional, Critser, Douglas, additional, Hinz, Connie J., additional, Karakas, Stefani, additional, Kirschner, Valerie, additional, Lester, Cheyanne, additional, Montague, Cindy, additional, Russell, Stephen, additional, Stockman, Heather, additional, Taylor, Barbara, additional, Verdick, Randy, additional, Walshire, Jean, additional, Thompson, John T., additional, Connell, Barbara, additional, Constantine, Maryanth, additional, Davis, John L., additional, Holsapple, Gwen, additional, Hunter, Lisa, additional, Lenane, C. Nicki, additional, Mitchell, Robin, additional, Russel, Leslie, additional, Sjaarda, Raymond, additional, Brown, David M., additional, Benz, Matthew, additional, Burns, Llewellyn, additional, Carranza, JoLene G., additional, Fish, Richard, additional, Goates, Debra, additional, Hay, Shayla, additional, Jeffers, Theresa, additional, Kegley, Eric, additional, Kubecka, Dallas, additional, McGilvra, Stacy, additional, Richter, Beau, additional, Sneed, Veronica, additional, Stoever, Cary, additional, Tellez, Isabell, additional, Wong, Tien, additional, Kim, Ivana, additional, Andreoli, Christopher, additional, Barresi, Leslie, additional, Brett, Sarah, additional, Callahan, Charlene, additional, Capaccioli, Karen, additional, Carli, William, additional, Coppola, Matthew, additional, Emmanuel, Nicholas, additional, Evans, Claudia, additional, Fagan, Anna, additional, Grillo, Marcia, additional, Head, John, additional, Kieser, Troy, additional, Lee, Elaine, additional, Lord, Ursula, additional, Miretsky, Edward, additional, Palitsch, Kate, additional, Petrin, Todd, additional, Reader, Liz, additional, Reznichenko, Svetlana, additional, Robertson, Mary, additional, Smith, Justin, additional, Vavvas, Demetrios, additional, Wells, John, additional, Cahill, Cassie, additional, Lloyd Clark, W., additional, Henry, Kayla, additional, Johnson, David, additional, Miller, Peggy, additional, Oliver, LaDetrick, additional, Spivey, Robbin, additional, Swinford, Tiffany, additional, Taylor, Mallie, additional, Lambert, Michael, additional, Chase, Kris, additional, Fredrickson, Debbie, additional, Khawly, Joseph, additional, Lazarte, Valerie, additional, Lowd, Donald, additional, Miller, Pam, additional, Willis, Arthur, additional, Ferrone, Philip J., additional, Almonte, Miguel, additional, Arnott, Rachel, additional, Aviles, Ingrid, additional, Carbon, Sheri, additional, Chitjian, Michael, additional, DAmore, Kristen, additional, Elliott, Christin, additional, Fastenberg, David, additional, Golub, Barry, additional, Graham, Kenneth, additional, Lavorna, AnnMarie, additional, Murphy, Laura, additional, Palomo, Amanda, additional, Puglisi, Christina, additional, Rhee, David, additional, Romero, Juan, additional, Rosenblatt, Brett, additional, Salcedo, Glenda, additional, Schlameuss, Marianne, additional, Shakin, Eric, additional, Sookhai, Vasanti, additional, Kaiser, Richard, additional, Affel, Elizabeth, additional, Brown, Gary, additional, Centinaro, Christina, additional, Fine, Deborah, additional, Fineman, Mitchell, additional, Formoso, Michele, additional, Garg, Sunir, additional, Grande, Lisa, additional, Herbert, Carolyn, additional, Ho, Allen, additional, Hsu, Jason, additional, Jay, Maryann, additional, Lavetsky, Lisa, additional, Liebenbaum, Elaine, additional, Maguire, Joseph, additional, Monsonego, Julia, additional, O'Connor, Lucia, additional, Pierce, Lisa, additional, Regillo, Carl, additional, Rosario, Maria, additional, Spirn, Marc, additional, Vander, James, additional, Walsh, Jennifer, additional, Davidorf, Frederick H., additional, Barnett, Amanda, additional, Chang, Susie, additional, Christoforidis, John, additional, Elliott, Joy, additional, Justice, Heather, additional, Letson, Alan, additional, McKinney, Kathryne, additional, Perry, Jeri, additional, Salerno, Jill A., additional, Savage, Scott, additional, Shelley, Stephen, additional, Singerman, Lawrence J., additional, Coney, Joseph, additional, DuBois, John, additional, DuBois, Kimberly, additional, Greanoff, Gregg, additional, Himmelman, Dianne, additional, Ilc, Mary, additional, Mcnamara, Elizabeth, additional, Novak, Michael, additional, Pendergast, Scott, additional, Rath, Susan, additional, Smith-Brewer, Sheila, additional, Tanner, Vivian, additional, Weiss, Diane E., additional, Zegarra, Hernando, additional, Halperin, Lawrence, additional, Aramayo, Patricia, additional, Dhalla, Mandeep, additional, Fernandez, Brian, additional, Fernandez, Cindy, additional, Lopez, Jaclyn, additional, Lopez, Monica, additional, Mariano, Jamie, additional, Murphy, Kellie, additional, Sherley, Clifford, additional, Veksler, Rita, additional, Rahhal, Firas, additional, Babikian, Razmig, additional, Boyer, David, additional, Hami, Sepideh, additional, Kessinger, Jeff, additional, Kurokouchi, Janet, additional, Mukarram, Saba, additional, Pachman, Sarah, additional, Protacio, Eric, additional, Sierra, Julio, additional, Tabandeh, Homayoun, additional, Zamboni, Adam, additional, Elman, Michael, additional, Belz, Jennifer, additional, Butcher, Tammy, additional, Cain, Theresa, additional, Coffey, Teresa, additional, Firestone, Dena, additional, Gore, Nancy, additional, Singletary, Pamela, additional, Sotirakos, Peter, additional, Starr, JoAnn, additional, Meredith, Travis A., additional, Barnhart, Cassandra J., additional, Cantrell, Debra, additional, Esquejo-Leon, RonaLyn, additional, Houghton, Odette, additional, Kaur, Harpreet, additional, NDure, Fatoumatta, additional, Glatzer, Ronald, additional, Joffe, Leonard, additional, Schindler, Reid, additional, Fine, Stuart L., additional, Katz, Marilyn, additional, Brightwell-Arnold, Mary, additional, Glaser, Ruchira, additional, Hall, Judith, additional, Harkins, Sandra, additional, Huang, Jiayan, additional, Khvatov, Alexander, additional, McWilliams, Kathy, additional, Peskin, Ellen, additional, Pistilli, Maxwell, additional, Ryan, Susan, additional, Schnader, Allison, additional, Ying, Gui-Shuang, additional, Jaffe, Glenn, additional, Afrani-Sakyi, Jennifer, additional, Balsley, Brannon, additional, Bennett, Linda S., additional, Brooks, Adam, additional, Brower-Lingsch, Adrienne, additional, Bruce, Lori, additional, Burns, Russell, additional, Busian, Dee, additional, Choong, John, additional, Cloaninger, Lindsey, additional, DeCroos, Francis Char, additional, DuBois, Emily, additional, El-Dairi, Mays, additional, Gach, Sarah, additional, Hall, Katelyn, additional, Hawks, Terry, additional, Huang, ChengChenh, additional, Heydary, Cindy, additional, Ho, Alexander, additional, Kini, Shashi, additional, McCall, Michelle, additional, Muhammad, Daaimah, additional, Nicholson, Jayne, additional, Rieves, Pamela, additional, Shields, Kelly, additional, Specker, Adam, additional, Stinnett, Sandra, additional, Subramaniam, Sujatha, additional, Tenbrink, Patrick, additional, Toth, Cynthia, additional, Towe, Aaron, additional, Welch, Kimberly, additional, Williams, Natasha, additional, Winter, Katrina, additional, Young, Ellen, additional, Alexander, Judith, additional, Flannagan, Elisabeth, additional, Martin, E. Revell, additional, Parker, Candace, additional, Sepielli, Krista, additional, Shannon, Tom, additional, Whearry, Claressa, additional, Redford, Maryann, additional, Kopfer, Marcia R., additional, Ferris, Frederick L., additional, DuPont, Joan, additional, Friedman, Lawrence M., additional, Bressler, Susan B., additional, DeMets, David L., additional, Friedlander, Martin, additional, Johnson, Mark W., additional, Lindblad, Anne, additional, Losordo, Douglas W., additional, and Miller, Franklin G., additional

Published
2015
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122. Acute Retinal Necrosis Presenting in Developmentally-delayed Patients with Neonatal Encephalitis: A Case Series and Literature Review.

Author

Okafor, Kingsley, Lu, Jonathan, Thinda, Sumeer, Schwab, Ivan, Morse, Lawrence S., Park, Susanna S., and Moshiri, Ala

Subjects
ENCEPHALITIS, NECROSIS, HERPES simplex virus, EYE examination, PATHOLOGICAL physiology, NEONATAL diseases, MENINGITIS in children, PATIENTS, ACYCLOVIR, DIAGNOSIS of developmental disabilities, THERAPEUTIC use of glucocorticoids, DIAGNOSIS of neonatal diseases, RETINAL disease diagnosis, ANTIVIRAL agents, HERPESVIRUSES, COMBINATION drug therapy, DEVELOPMENTAL disabilities, DNA, POLYMERASE chain reaction, RETINAL diseases, VIRAL antibodies, VITREOUS body, VIRAL encephalitis, PHYSIOLOGY, VIRAL eye infections, DIAGNOSIS, THERAPEUTICS
Abstract

We report three cases of patients with developmental-delay from neonatal herpetic encephalitis and/or meningitis who presented years later with acute retinal necrosis due to herpes simplex virus. The diagnosis was delayed in all cases due to the patients’ inability to verbalize their ocular complaints and cooperate with eye examinations. This case series documents the clinical course, pathophysiologic mechanism, and treatment of acute retinal necrosis in this patient population. Clinicians should understand the importance of prudent consideration of acute retinal necrosis in patients with a history of neonatal herpetic encephalitis and/or meningitis presenting with a red eye. [ABSTRACT FROM PUBLISHER]

Published
2017
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124. Staging of macular telangiectasia: power-Doppler optical coherence tomography and macular pigment optical density.

Author

Chin, Eric K, Chin, Eric K, Kim, Dae Yu, Hunter, Allan A, Pilli, Suman, Wilson, Machelle, Zawadzki, Robert J, Werner, John S, Park, Susanna S, Chin, Eric K, Chin, Eric K, Kim, Dae Yu, Hunter, Allan A, Pilli, Suman, Wilson, Machelle, Zawadzki, Robert J, Werner, John S, and Park, Susanna S

Abstract

PurposeTwo methods were used to study the stages of macular telangiectasia (MACTEL): Power-Doppler optical coherence tomography (PD-OCT), which allows imaging of the retinal circulation in three dimensions, and macular pigment optical density (MPOD), which quantifies the distribution of macular carotenoids.MethodsAmong 49 patients with MacTel identified, 12 eyes (6 patients) with MacTel and 7 age-matched control eyes (7 patients) were imaged with a custom-built Fourier-domain OCT instrument to acquire PD-OCT images. MPOD was measured using heterochromatic flicker photometry in 10 eyes (5 patients) with MacTel and compared with 44 age-matched control eyes (44 patients). Clinical staging of MacTel was based on best-corrected visual acuity, fundus biomicroscopy, fluorescein angiography, and OCT.ResultsStage 1 eyes (n = 2) had subtle punctate vascular signal confined to the inner portion of the outer plexiform layer (OPL) on PD-OCT. Stage 2 (n = 2) showed larger oblique vascular signal extending into deeper OPL. Stage 3 (n = 5) had disruption of outer retinal layers with abnormal vasculature extending into the outer nuclear layer. Stage 4 (n = 3) showed diffuse blurring of the retinal layers with vascular channels extending the full thickness of the retina. MPOD values in four eyes with stage 1 or 2 MacTel correlated well with age-matched controls. Six eyes with stage 3 or 4 MacTel had loss of MPOD especially at the fovea.ConclusionsPD-OCT shows penetration of the retinal capillaries into the deeper retinal layers in early stages of MacTel, with full thickness vascular proliferation in advanced disease. MPOD is commonly depleted but may appear normal in early stage MacTel.

Published
2013

125. Five-year follow-up of macular morphologic changes after rhegmatogenous retinal detachment repair: Fourier domain OCT findings.

Author

Rashid, Saadia, Rashid, Saadia, Pilli, Suman, Chin, Eric K, Zawadzki, Robert J, Werner, John S, Park, Susanna S, Rashid, Saadia, Rashid, Saadia, Pilli, Suman, Chin, Eric K, Zawadzki, Robert J, Werner, John S, and Park, Susanna S

Abstract

PurposeTo evaluate serially long-term macular morphologic changes after successful macula-involving rhegmatogenous retinal detachment repair and correlate changes with macular function.MethodsRepeat Fourier domain optical coherence tomography (FD OCT) imaging and microperimetry (MP-1) testing of 8 of the initial cohort of 17 eyes studied 5 years earlier.ResultsThe mean follow-up after rhegmatogenous retinal detachment repair was 3.4 months (range, 1-8.5 months) for the first FD OCT and 5 years (range, 3.75-5.75 years) for the follow-up FD OCT. The final postoperative best-corrected visual acuity mean was 20/201 (range, 20/20 to counting fingers). Six eyes with final best-corrected visual acuity >20/40 had an intact external limiting membrane and progressive resolution of photoreceptor inner segment-outer segment junction disruption and/or subretinal fluid on serial FD OCT, which correlated with improvement in macular function on MP-1. Two eyes with poor or worsening best-corrected visual acuity on follow-up had persistent or worsening inner segment-outer segment disruption on serial FD OCT. External limiting membrane was intact in one eye and persistently disrupted in the other.ConclusionMacular function may progressively improve or worsen long-term after successful rhegmatogenous retinal detachment repair. Progressive resolution of subretinal fluid and/or inner segment-outer segment disruption on FD OCT correlated with improvement in macular function, whereas worsening or persistent inner segment-outer segment disruption correlates with worsening or persistently poor visual outcome.

Published
2013

131. Long-Term Effects of Intravitreal Injection of GMP-Grade Bone-Marrow–Derived CD34+Cells in NOD-SCID Mice with Acute Ischemia-Reperfusion Injury

Author

Park, Susanna S., primary, Caballero, Sergio, additional, Bauer, Gerhard, additional, Shibata, Bradley, additional, Roth, Alan, additional, Fitzgerald, Paul G., additional, Forward, Krisztina I., additional, Zhou, Ping, additional, McGee, Jeannine, additional, Telander, David G., additional, Grant, Maria B., additional, and Nolta, Jan A., additional

Published
2012
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132. Photoreceptor Imaging

Author

Park, Susanna S., primary, Choi, Stacey S., additional, Zawadzki, Robert J., additional, and Werner, John S., additional

Published
2012
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137. Author reply

Author

Park, Susanna S., primary, Zawadzki, Robert J., additional, and Werner, John S., additional

Published
2009
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148. Optical imaging of the chorioretinal vasculature in the living human eye.

Author

Dae Yu Kim, Fingler, Jeff, Zawadzki, Robert J., Park, Susanna S., Morse, Lawrence S., Schwartz, Daniel M., Fraser, Scott E., and Werner, John S.

Subjects
RETINAL blood vessels, OPTICAL imaging sensors, VISUALIZATION, MICROVASCULAR angina, ANGIOGRAPHY, INTRAVENOUS injections, OPTICAL coherence tomography
Abstract

Detailed visualization of microvascular changes in the human retina is clinically limited by the capabilities of angiography imaging, a 2D fundus photograph that requires an intravenous injection of fluorescent dye. Whereas current angiography methods enable visualization of some retinal capillary detail, they do not adequately reveal the choriocapillaris or other microvascular features beneath the retina. We have developed a noninvasive microvascular imaging technique called phase-variance optical coherence tomography (pvOCT), which identifies vasculature three dimensionally through analysis of data acquired with OCT systems. The pvOCT imaging method is not only capable of generating capillary perfusion maps for the retina, but it can also use the 3D capabilities to segment the data in depth to isolate vasculature in different layers of the retina and choroid. This paper demonstrates some of the capabilities of pvOCT imaging of the anterior layers of choroidal vasculature of a healthy normal eye as well as of eyes with geographic atrophy (GA) secondary to age-related macular degeneration. The pvOCT data presented permit digital segmentation to produce 2D depth-resolved images of the retinal vasculature, the choriocapillaris, and the vessels in Sattler's and Haller's layers. Comparisons are presented between en face projections of pvOCT data within the superficial choroid and clinical angiography images for regions of GA. Abnormalities and vascular dropout observed within the choriocapillaris for pvOCT are compared with regional GA progression. The capability of pvOCT imaging of the microvasculature of the choriocapillaris and the anterior choroidal vasculature has the potential to become a unique tool to evaluate therapies and understand the underlying mechanisms of age-related macular degeneration progression. [ABSTRACT FROM AUTHOR]

Published
2013
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150. International Classification System for Ocular Complications of Anti-VEGF Agents in Clinical Trials.

Author

Popovic, Marko M., Balas, Michael, Sadda, SriniVas R., Sarraf, David, Huang, Ryan, Bakri, Sophie J., Berrocal, Audina, Chang, Andrew, Gemmy Cheung, Chui Ming, Garg, Sunir, Hillier, Roxane J., Holz, Frank G., Johnson, Mark W., Kaiser, Peter K., Kertes, Peter J., Lai, Timothy Y.Y., Noble, Jason, Park, Susanna S., Paulus, Yannis M., and Querques, Giuseppe

Subjects
*DELPHI method, *RANDOMIZED controlled trials, *RISK assessment, *VASCULAR endothelial growth factor antagonists, *CLINICAL trials
Abstract

Complications associated with intravitreal anti-VEGF therapies are reported inconsistently in the literature, thus limiting an accurate evaluation and comparison of safety between studies. This study aimed to develop a standardized classification system for anti-VEGF ocular complications using the Delphi consensus process. Systematic review and Delphi consensus process. Twenty-five international retinal specialists participated in the Delphi consensus survey. A systematic literature search was conducted to identify complications of intravitreal anti-VEGF agent administration based on randomized controlled trials (RCTs) of anti-VEGF therapy. A comprehensive list of complications was derived from these studies, and this list was subjected to iterative Delphi consensus surveys involving international retinal specialists who voted on inclusion, exclusion, rephrasing, and addition of complications. Furthermore, surveys determined specifiers for the selected complications. This iterative process helped to refine the final classification system. The proportion of retinal specialists who choose to include or exclude complications associated with anti-VEGF administration. After screening 18 229 articles, 130 complications were categorized from 145 included RCTs. Participant consensus via the Delphi method resulted in the inclusion of 91 complications (70%) after 3 rounds. After incorporating further modifications made based on participant suggestions, such as rewording certain phrases and combining similar terms, 24 redundant complications were removed, leaving a total of 67 complications (52%) in the final list. A total of 14 complications (11%) met exclusion thresholds and were eliminated by participants across both rounds. All other remaining complications not meeting inclusion or exclusion thresholds also were excluded from the final classification system after the Delphi process terminated. In addition, 47 of 75 proposed complication specifiers (63%) were included based on participant agreement. Using the Delphi consensus process, a comprehensive, standardized classification system consisting of 67 ocular complications and 47 unique specifiers was established for intravitreal anti-VEGF agents in clinical trials. The adoption of this system in future trials could improve consistency and quality of adverse event reporting, potentially facilitating more accurate risk-benefit analyses. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. [ABSTRACT FROM AUTHOR]

Published
2024
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