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2,130 results on '"Park, Ki Ho"'

109. Reply to Bernard et al

Author

Park, Ki-Ho, Cho, Oh-Hyun, Choi, Sang-Ho, Bae, In-Gyue, and Lee, Mi Suk

Published
2016

113. Intraocular pressure reduction and progression of highly myopic glaucoma: a 12-year follow-up cohort study

Author

Shin, Young In, Kim, Young Kook, Jeoung, Jin Wook, and Park, Ki Ho

Abstract

AimsTo investigate any association between intraocular pressure (IOP) reduction amount and open-angle glaucoma (OAG) progression in highly myopic eyes and to determine the associated risk factors.MethodsOne hundred and thirty-one (131) eyes of 131 patients with highly myopic OAG, all of whom had received topical medications and been followed for 5 years or longer, were enrolled. Based on the IOP reduction percentage, patients were categorised into tertile groups, and subsequently, the upper-tertile and lower-tertile groups were compared for the cumulative probability of glaucoma progression. Kaplan-Meier survival analysis and log-rank testing were applied in the comparison, and multivariate analysis with Cox’s proportional hazard model, additionally, was performed to identify progression risk factors.ResultsThroughout the average 11.6±4.4 year follow-up on the 131 eyes (mean age, 41.2 years at initial visit; baseline IOP, 16.4 mm Hg), 72 eyes (55.0%) showed glaucoma progression. The upper-tertile group (IOP reduction percentage>23.7%) showed a high cumulative probability of non-progression relative to the lower-tertile group (IOP reduction percentage<11.0%; p=0.034), according to the Kaplan-Meier analysis. Presence of disc haemorrhage (DH; HR=2.189; p=0.032) was determined by the multivariate Cox’s proportional hazard model to be significantly associated with glaucoma progression. For progressors, the average rate of retinal nerve fibre layer thickness thinning was −0.88±0.74 µm/year, while the MD change was −0.42±0.36 dB/year.ConclusionsGlaucoma progression is associated with amount of IOP reduction by topical medications in highly myopic eyes, and DH occurrence is a glaucoma progression risk factor.

Published
2024
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114. Deep-learning-based prediction of glaucoma conversion in normotensive glaucoma suspects

Author

Ha, Ahnul, Sun, Sukkyu, Kim, Young Kook, Jeoung, Jin Wook, Kim, Hee Chan, and Park, Ki Ho

Abstract

Background/aimsTo assess the performance of deep-learning (DL) models for prediction of conversion to normal-tension glaucoma (NTG) in normotensive glaucoma suspect (GS) patients.MethodsDatasets of 12 458 GS eyes were reviewed. Two hundred and ten eyes (105 eyes showing NTG conversion and 105 without conversion), followed up for a minimum of 7 years during which intraocular pressure (IOP) was lower than 21 mm Hg, were included. The features of two fundus images (optic disc photography and red-free retinal nerve fibre layer (RNFL) photography) were extracted by convolutional auto encoder. The extracted features as well as 15 clinical features including age, sex, IOP, spherical equivalent, central corneal thickness, axial length, average circumpapillary RNFL thickness, systolic/diastolic blood pressure and body mass index were used to predict NTG conversion. Prediction was performed using three machine-learning classifiers (ie, XGBoost, Random Forest, Gradient Boosting) with different feature combinations.ResultsAll three algorithms achieved high diagnostic accuracy for NTG conversion prediction. The AUCs ranged from 0.987 (95% CI 0.978 to 1.000; Random Forest trained with both fundus images and clinical features) and 0.994 (95% CI 0.984 to 1.000; XGBoost trained with both fundus images and clinical features). XGBoost showed the best prediction performance for time to NTG conversion (mean squared error, 2.24). The top three important clinical features for time-to-conversion prediction were baseline IOP, diastolic blood pressure and average circumpapillary RNFL thickness.ConclusionDL models, trained with both fundus images and clinical data, showed the potential to predict whether and when normotensive GS patients will show conversion to NTG.

Published
2024
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122. Sustained elevation of MG53 in the bloodstream increases tissue regenerative capacity without compromising metabolic function

Author

Bian, Zehua, Wang, Qiang, Zhou, Xinyu, Tan, Tao, Park, Ki Ho, Kramer, H. Fritz, McDougal, Alan, Laping, Nicholas J., Kumar, Sanjay, Adesanya, T. M. Ayodele, Sermersheim, Matthew, Yi, Frank, Wang, Xinxin, Wu, Junwei, Gumpper, Kristyn, Jiang, Qiwei, He, Duofen, Lin, Pei-Hui, Li, Haichang, Guan, Fangxia, Zhou, Jingsong, Kohr, Mark J., Zeng, Chunyu, Zhu, Hua, and Ma, Jianjie

Published
2019
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126. Complement C3-Deficiency-Induced Constipation in FVB/N-C3 em1Hlee /Korl Knockout Mice Was Significantly Relieved by Uridine and Liriope platyphylla L. Extracts.

Author

Song, Hee-Jin, Kim, Ji-Eun, Jin, You-Jeong, Roh, Yu-Jeong, Seol, Ayun, Kim, Tae-Ryeol, Park, Ki-Ho, Park, Eun-Seo, An, Beum-Soo, Yang, Seung-Yun, Seo, Sungbaek, Jo, Seong-Min, Jung, Young-Suk, and Hwang, Dae-Youn

Subjects
CHOLINERGIC receptors, URIDINE, KNOCKOUT mice, COMPLEMENT (Immunology), ENTERIC nervous system, MUSCARINIC acetylcholine receptors, CONSTIPATION, NITRIC-oxide synthases
Abstract

Complement component 3 (C3) deficiency has recently been known as a cause of constipation, without studies on the therapeutic efficacy. To evaluate the therapeutic agents against C3-deficiency-induced constipation, improvements in the constipation-related parameters and the associated molecular mechanisms were examined in FVB/N-C3em1Hlee/Korl knockout (C3 KO) mice treated with uridine (Urd) and the aqueous extract of Liriope platyphylla L. (AEtLP) with laxative activity. The stool parameters and gastrointestinal (GI) transit were increased in Urd- and AEtLP-treated C3 KO mice compared with the vehicle (Veh)-treated C3 KO mice. Urd and AEtLP treatment improved the histological structure, junctional complexes of the intestinal epithelial barrier (IEB), mucin secretion ability, and water retention capacity. Also, an improvement in the composition of neuronal cells, the regulation of excitatory function mediated via the 5-hydroxytryptamine (5-HT) receptors and muscarinic acetylcholine receptors (mAChRs), and the regulation of the inhibitory function mediated via the neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS) were detected in the enteric nervous system (ENS) of Urd- and AEtLP-treated C3 KO mice. Therefore, the results of the present study suggest that C3-deficiency-induced constipation can improve with treatment with Urd and AEtLP via the regulation of the mucin secretion ability, water retention capacity, and ENS function. [ABSTRACT FROM AUTHOR]

Published
2023
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143. The Impact of the COVID-19 Pandemic on Otitis Media

Author

Choi, Soo-Young, primary, Yon, Dong-Keon, additional, Choi, Yong-Sung, additional, Lee, Jinseok, additional, Park, Ki-Ho, additional, Lee, Young-Ju, additional, Kim, Sung-Soo, additional, Kim, Sang-Hoon, additional, and Yeo, Seung-Geun, additional

Published
2022
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145. Acceptance and Perception of Artificial Intelligence Usability in Eye Care (APPRAISE) for Ophthalmologists: A Multinational Perspective

Author

Gunasekeran, Dinesh V., primary, Zheng, Feihui, additional, Lim, Gilbert Y. S., additional, Chong, Crystal C. Y., additional, Zhang, Shihao, additional, Ng, Wei Yan, additional, Keel, Stuart, additional, Xiang, Yifan, additional, Park, Ki Ho, additional, Park, Sang Jun, additional, Chandra, Aman, additional, Wu, Lihteh, additional, Campbel, J. Peter, additional, Lee, Aaron Y., additional, Keane, Pearse A., additional, Denniston, Alastair, additional, Lam, Dennis S. C., additional, Fung, Adrian T., additional, Chan, Paul R. V., additional, Sadda, SriniVas R., additional, Loewenstein, Anat, additional, Grzybowski, Andrzej, additional, Fong, Kenneth C. S., additional, Wu, Wei-chi, additional, Bachmann, Lucas M., additional, Zhang, Xiulan, additional, Yam, Jason C., additional, Cheung, Carol Y., additional, Pongsachareonnont, Pear, additional, Ruamviboonsuk, Paisan, additional, Raman, Rajiv, additional, Sakamoto, Taiji, additional, Habash, Ranya, additional, Girard, Michael, additional, Milea, Dan, additional, Ang, Marcus, additional, Tan, Gavin S. W., additional, Schmetterer, Leopold, additional, Cheng, Ching-Yu, additional, Lamoureux, Ecosse, additional, Lin, Haotian, additional, van Wijngaarden, Peter, additional, Wong, Tien Y., additional, and Ting, Daniel S. W., additional

Published
2022
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