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101. Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway

Author

Park, Seong-Min, Seo, Eun-Hye, Bae, Dong-Hyuck, Kim, Sung Soo, Kim, Jina, Lin, Weiwei, Kim, Kyung-Hee, Park, Jong Bae, Kim, Yong Sung, Yin, Jinlong, and Kim, Seon-Young

Subjects
L-serine independent pathway, Lung Neoplasms, Articles, Survival Analysis, Phosphoric Monoester Hydrolases, phosphoserine phosphatase, lung cancer, Mice, A549 Cells, Disease Progression, Insulin Receptor Substrate Proteins, Serine, Animals, Humans, Neoplasm Invasiveness, Phosphorylation, IRS-1, Tumor Stem Cell Assay, Signal Transduction
Abstract

Phosphoserine phosphatase (PSPH) is one of the key enzymes of the L-serine synthesis pathway. PSPH is reported to affect the progression and survival of several cancers in an L-serine synthesis-independent manner, but the mechanism remains elusive. We demonstrate that PSPH promotes lung cancer progression through a noncanonical L-serine-independent pathway. PSPH was significantly associated with the prognosis of lung cancer patients and regulated the invasion and colony formation of lung cancer cells. Interestingly, L-serine had no effect on the altered invasion and colony formation by PSPH. Upon measuring the phosphatase activity of PSPH on a serine-phosphorylated peptide, we found that PSPH dephosphorylated phospho-serine in peptide sequences. To identify the target proteins of PSPH, we analyzed the protein phosphorylation profile and the PSPH-interacting protein profile using proteomic analyses and found one putative target protein, IRS-1. Immunoprecipitation and immunoblot assays validated a specific interaction between PSPH and IRS-1 and the dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells. We suggest that the specific interaction and dephosphorylation activity of PSPH have novel therapeutic potential for lung cancer treatment, while the metabolic activity of PSPH, as a therapeutic target, is controversial.

Published
2019

113. Power System Planning and Operation

Author

Simon, Sishaj Pulikottil, Padhy, Narayana Prasad, Park, Jong-Bae, Lee, Kwang Y., Zhou, Ming, Xia, Shu, da Silva, Anna Carolina R.H., Choi, Jaeseok, Lee, Yeonchan, Lambert-Torres, Germano, Salomon, Camila Paes, da Silva, Luiz Eduardo Borges, Bai, Wenlei, Eke, Ibrahim, Rueda, Jose, Carvalho, Leonel, Miranda, Vladimiro, Erlich, Istvan, Theologi, Aimilia-Myrsini, Asada, Eduardo N., Souza, Aldir S., Romero, Rubén, Silva, Alexandre P. Alves, Silva, Anna Carolina R.H., Choi, Jeaseok, and Silva, Luiz Eduardo Borges

Subjects
Schedule, Mathematical optimization, Electric power system, Power system simulation, Electric power transmission, Computer science, Economic dispatch, Maximum power transfer theorem, Particle swarm optimization, Power (physics), Elektrotechnik
Abstract

This chapter provides implementation of various optimization algorithms to various power system problems that utilize power flow calculations. Determination of the schedule (ON/OFF status and amount of power generated) of generating units within a power system results in great saving for electric utilities. The unit commitment problem can be formulated in order to minimize the total operating cost, satisfying the system, the unit, and several operational constraints. The power transfer limit of overhead transmission lines (OTLs) is an important constraint for power systems’ planning and operation. This constraint plays an essential role in the secure and economic management of power systems. The chapter presents economic dispatch problem by considering GAs and particle swarm optimization (PSO) in complex power system analysis. It uses a hybrid PSO to solve load flow problem while uses artificial bee colony optimization for solving the optimal power flow problem.

Published
2020

114. Additional file 2 of Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

Author

Sa, Jason K., Nakho Chang, Lee, Hye Won, Cho, Hee Jin, Ceccarelli, Michele, Cerulo, Luigi, Jinlong Yin, Kim, Sung Soo, Caruso, Francesca P., Mijeong Lee, Donggeon Kim, Oh, Young Taek, Yeri Lee, Nam-Gu Her, Byeongkwi Min, Kim, Hye-Jin, Jeong, Da Eun, Kim, Hye-Mi, Hyunho Kim, Chung, Seok, Woo, Hyun Goo, Jeongwu Lee, Doo-Sik Kong, Seol, Ho Jun, Lee, Jung-Il, Jinho Kim, Woong-Yang Park, Qianghu Wang, Sulman, Erik P., Heimberger, Amy B., Lim, Michael, Park, Jong Bae, Iavarone, Antonio, Verhaak, Roel G. W., and Do-Hyun Nam

Abstract

Additional file 2. Review History.

Published
2020
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115. Additional file 1 of Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma

Author

Sa, Jason K., Nakho Chang, Lee, Hye Won, Cho, Hee Jin, Ceccarelli, Michele, Cerulo, Luigi, Jinlong Yin, Kim, Sung Soo, Caruso, Francesca P., Mijeong Lee, Donggeon Kim, Oh, Young Taek, Yeri Lee, Nam-Gu Her, Byeongkwi Min, Kim, Hye-Jin, Jeong, Da Eun, Kim, Hye-Mi, Hyunho Kim, Chung, Seok, Woo, Hyun Goo, Jeongwu Lee, Doo-Sik Kong, Seol, Ho Jun, Lee, Jung-Il, Jinho Kim, Woong-Yang Park, Qianghu Wang, Sulman, Erik P., Heimberger, Amy B., Lim, Michael, Park, Jong Bae, Iavarone, Antonio, Verhaak, Roel G. W., and Do-Hyun Nam

Subjects
stomatognathic system, skin and connective tissue diseases, hormones, hormone substitutes, and hormone antagonists
Abstract

Additional file 1: Figure S1. A schematic illustration on identification of MA-TAM signature and master regulators. Figure S2. MA-TAM target gene pathway enrichment. Figure S3. Global regulatory network of MA-TAM. Figure S4. Multi-color immunohistochemical images of MA-TAM encoding molecules. Figure S5. Effects of MARCO and CCL7 on mesenchymal markers. Figure S6. Effects of TAM-derived CM on GSC stemness in response to irradiation. Figure S7. Effects of anti-MARCO therapeutic antibodies. Figure S8. In vivo effects of MARCOhigh TAMs in PDX models. Figure S9. Clinical correlation of MA-TAM master regulators. Figure S10. Single cell analysis of MA-TAM signature. Figure S11. Transcriptome analysis of scTHI at single-cell resolution. Figure S12. Cytokine array-based characterization of MARCOhigh TAMs. Figure S13. Anatomical expression of MA-TAM signature.

Published
2020
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116. A new optimal routing algorithm for loss minimization and voltage stability improvement in radial power systems

Author

Shin, Joong-Rin, Kim, Byung-Seop, Park, Jong-Bae, and Lee, Kwang Y.

Subjects
Electric power systems -- Analysis, Algorithms -- Analysis, Algorithm, Business, Electronics, Electronics and electrical industries
Abstract

This paper presents an optimal routing algorithm (ORA) for minimizing power loss and at the same time maximizing the voltage stability in radial power systems. In the proposed ORA, a voltage stability index (VSI) for real-time assessment is introduced based on the conventional critical transmission path framework. In addition, the algorithm can automatically detect the critical transmission paths that will result in voltage collapse when additional real or reactive loads are added. To implement effective ORA, an improved branch exchange (IBE) method has been developed based on a loss calculation index and tie-branch power flows that is suited for real-time applications. The proposed algorithm has been tested in the IEEE 32- and 69-bus systems as well as in a large-scale Korea Electric Power Company 148-bus system to show its effectiveness and efficiency. Index Terms--Branch exchange, combinatorial optimization, loss minimization, optimal routing algorithm (ORA), radial power system, voltage stability index (VSI).

Published
2007

117. Protein nanopatterns and biosensors using gold binding polypeptide as a fusion partner

Author

Park, Tae Jung, Lee, Sang Yup, Lee, Seok Jae, Park, Jong Pil, Yang, Kwang Suk, Lee, Kyung-Bok, Ko, Sungho, Park, Jong Bae, Kim, Taekeun, Kim, Seong Kyu, Shin, Yong Bum, Chung, Bong Hyun, Ku, Su-Jin, Kim, Do Hyun, and Choi, Insung S.

Subjects
Protein binding -- Research, Biosensors -- Usage, Polypeptides -- Chemical properties, Atomic force microscopy -- Observations, Chemistry
Abstract

An efficient strategy for immobilizing proteins on a gold surface was developed by employing the gold binding polypeptide (GBP) as a fusion partner. Using the enhanced green fluorescent protein (EGFP), severe acute respiratory syndrome coronavirus (SARS-CoV) envelope protein (SCVme), and core streptavidin (cSA) of Streptomyces avidinii as model proteins, specific immobilization of the GBP-fusion proteins onto the gold nanoparticles and generation of protein nanopatterns on the bare gold surface were demonstrated. The GBP-fused SCVme bound to gold nanoparticles successfully interacted with its antibody and showed changes in absorbance and color, allowing efficient diagnosis of SARS-CoV. The fusion proteins could be successfully immobilized on the gold surface by nanopatterning and microcontact printing as examined by atomic force microscopy and surface plasmon resonance analysis. The poly(dimethylsiloxane) microfluidic channels were created on the gold surface and were used for antigen-antibody and DNA--DNA interaction studies. Specific immobilization of GBP--EGFP fusion protein and its interaction with the antibody in the microchannels could be demonstrated. By immobilizing the DNA probe through the use of GBP-fused cSA, specific hybridization of the target DNA prepared from Salmonella could also be achieved. The GBP-fusion method allows immobilization of proteins onto the gold surface without surface modification and in bioactive forms suitable for studying protein--protein, DNA--DNA, and other biomolecular interaction studies. Furthermore, these studies can be carried out in a microfluidic system, which allows high-throughput analysis of biomolecular interactions.

Published
2006

120. Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma

Author

Hong, Jun-Hee, primary, Kang, Sangjo, additional, Sa, Jason K, additional, Park, Gunwoo, additional, Oh, Young Taek, additional, Kim, Tae Hoon, additional, Yin, Jinlong, additional, Kim, Sung Soo, additional, D’Angelo, Fulvio, additional, Koo, Harim, additional, You, Yeonhee, additional, Park, Saewhan, additional, Kwon, Hyung Joon, additional, Kim, Chan Il, additional, Ryu, Haseo, additional, Lin, Weiwei, additional, Park, Eun Jung, additional, Kim, Youn-Jae, additional, Park, Myung-Jin, additional, Kim, Hyunggee, additional, Kim, Mi-Suk, additional, Chung, Seok, additional, Park, Chul-Kee, additional, Park, Sung-Hye, additional, Kang, Yun Hee, additional, Kim, Jong Heon, additional, Saya, Hideyuki, additional, Nakano, Ichiro, additional, Gwak, Ho-Shin, additional, Yoo, Heon, additional, Lee, Jeongwu, additional, Hur, Eun-Mi, additional, Shi, Bingyang, additional, Nam, Do-Hyun, additional, Iavarone, Antonio, additional, Lee, Seung-Hoon, additional, and Park, Jong Bae, additional

Published
2021
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121. Molecular Signature of Extracellular Vesicular Small Non-Coding RNAs Derived from Cerebrospinal Fluid of Leptomeningeal Metastasis Patients: Functional Implication of miR-21 and Other Small RNAs in Cancer Malignancy

Author

Lee, Kyue-Yim, primary, Seo, Yoona, additional, Im, Ji Hye, additional, Rhim, Jiho, additional, Baek, Woosun, additional, Kim, Sewon, additional, Kwon, Ji-Woong, additional, Yoo, Byong Chul, additional, Shin, Sang Hoon, additional, Yoo, Heon, additional, Park, Jong Bae, additional, Gwak, Ho-Shin, additional, and Kim, Jong Heon, additional

Published
2021
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124. A particle swarm optimization for economic dispatch with nonsmooth cost functions

Author

Park, Jong-Bae, Lee, Ki-Song, Shin, Joong-Rin, and Lee, Kwang Y.

Subjects
Electric power distribution -- Research, Algorithms, Algorithm, Business, Electronics, Electronics and electrical industries
Abstract

This paper presents a new approach to economic dispatch (ED) problems with nonsmooth cost functions using a particle swarm optimization (PSO) technique. The practical ED problems have nonsmooth cost functions with equality and inequality constraints that make the problem of finding the global optimum difficult using any mathematical approaches. In this paper, a modified PSO (MPSO) mechanism is suggested to deal with the equality and inequality constraints in the ED problems. A constraint treatment mechanism is devised in such a way that the dynamic process inherent in the conventional PSO is preserved. Moreover, a dynamic search-space reduction strategy is devised to accelerate the optimization process. To show its efficiency and effectiveness, the proposed MPSO is applied to test ED problems, one with smooth cost functions and others with nonsmooth cost functions considering valve-point effects and multi-fuel problems. The results of the MPSO are compared with the results of conventional numerical methods, Tabu search method, evolutionary programming approaches, genetic algorithm, and modified Hopfield neural network approaches. Index Terms--Constrained optimization, economic dispatch (ED), nonsmooth optimization, particle swarm optimization (PSO).

Published
2005

126. A new game-theoretic framework for maintenance strategy analysis

Author

Kim, Jin-Ho, Park, Jong-Bae, Park, Jong-Keun, and Kim, Balho H.

Subjects
Electric utilities -- Management, Company business management, Business, Electronics, Electronics and electrical industries
Abstract

In this paper, a new approach to maintenance scheduling of generating units (MSU) in competitive electricity markets is presented. The main contribution of this study can be focused on modeling a game-theoretic framework for the MSU problem to analyze strategic behaviors of generating companies (Gencos). The MSU problem is formulated as a dynamic noncooperative game with complete information. The player corresponds to the profit maximizing individual Genco, and the payoff of each player is defined as the profit from the energy auction market. The optimal strategy profile is defined by the Nash equilibrium of the game. Numerical results for two-Genco systems are used to demonstrate the basic ideas of the proposed scheme, and large-scale IEEE reliability test systems are also considered to show the applicability of the proposed framework. The results obtained indicate that maintenance schedule can be one of the crucial strategic behaviors whereby Genco maximizes their profit in a competitive market environment. Index Terms--Competitive market, dynamic noncooperative game, maintenance scheduling of generating unit, maintenance strategy, Nash equilibrium.

Published
2003

136. Nanoparticles in 472 Human Cerebrospinal Fluid: Changes in Extracellular Vesicle Concentration and miR-21 Expression as a Biomarker for Leptomeningeal Metastasis

Author

Lee, Kyue-Yim, primary, Im, Ji Hye, additional, Lin, Weiwei, additional, Gwak, Ho-Shin, additional, Kim, Jong Heon, additional, Yoo, Byong Chul, additional, Kim, Tae Hoon, additional, Park, Jong Bae, additional, Park, Hyeon Jin, additional, Kim, Ho-Jin, additional, Kwon, Ji-Woong, additional, Shin, Sang Hoon, additional, Yoo, Heon, additional, and Lee, Changjin, additional

Published
2020
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139. An Asian Perspective of the Management of COVID-19: the Asian National Cancer Centers Alliance Led Regional Comparison

Author

Dewi, Luh Komang Mela, primary, Gatellier, Laureline, primary, Sabapathy, Kanaga, primary, Pramesh, C S, primary, Dai, Min, primary, Huong, Tran Thanh, primary, Gultekin, Murat, primary, Nansalmaa, Erdenekhuu, primary, Htwe, Khin Khin, primary, Yusuf, Aasim, primary, Tahmasebi, Mamak, primary, Pradhananga, Kishore Kumar, primary, Park, Jong Bae, primary, Hanapiah, Suhaila Md, primary, Sangrajran, Suleeporn, primary, Baral, Rajendra Prasad, primary, Jayusman, Achmad Mulawarman, primary, Iwata, Satoshi, primary, Wei Kwek, Jin, primary, Sengar, Manju, primary, Chinnaswamy, Girish, primary, He, Jie, primary, Tian, Gu, primary, Huyen, Phung Thi, primary, Thuan, Tran Van, primary, Luvsanjodorj, Bayarsaikhan, primary, Myint, Yi Yi, primary, Young Chun, June, primary, Han, Jong Soo, primary, Hwang, William Ying Khee, primary, Sari, Nina Kemala, primary, and Matsuda, Tomohiro, primary

Published
2020
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140. ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages

Author

Yin, Jinlong, primary, Kim, Sung Soo, additional, Choi, Eunji, additional, Oh, Young Taek, additional, Lin, Weiwei, additional, Kim, Tae-Hoon, additional, Sa, Jason K., additional, Hong, Jun Hee, additional, Park, Se Hwan, additional, Kwon, Hyung Joon, additional, Jin, Xiong, additional, You, Yeonhee, additional, Kim, Ji Hye, additional, Kim, Hyunggee, additional, Son, Jaekyoung, additional, Lee, Jeongwu, additional, Nam, Do-Hyun, additional, Choi, Kui Son, additional, Shi, Bingyang, additional, Gwak, Ho-Shin, additional, Yoo, Heon, additional, Iavarone, Antonio, additional, Kim, Jong Heon, additional, and Park, Jong Bae, additional

Published
2020
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141. An Asian Body to Tackle Cancers in Asia – The Asian National Cancer Centers Alliance

Author

Gatellier, Laureline, primary, Matsuda, Tomohiro, additional, Sabapathy, Kanaga, additional, Dai, Min, additional, Dewi, Luh Komang Mela, additional, Huong, Tran Thanh, additional, Kardinah, Kardinah, additional, Thuan, Tran Van, additional, Park, Jong Bae, additional, He, Jie, additional, Nansalmaa, Erdenekhuu, additional, Luvsandorj, Bayarsaikhan, additional, Hwang, William Ying Khee, additional, Sengar, Manju, additional, Pramesh, CS, additional, and Suzuki, Tatsuya, additional

Published
2020
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144. POWER SYSTEM PLANNING AND OPERATION

Author

Simon, Sishaj Pulikottil, primary, Padhy, Narayana Prasad, additional, Park, Jong‐Bae, additional, Lee, Kwang Y., additional, Zhou, Ming, additional, Xia, Shu, additional, Silva, Alexandre P. Alves, additional, Silva, Anna Carolina R.H., additional, Choi, Jeaseok, additional, Lee, Yeonchan, additional, Lambert‐Torres, Germano, additional, Salomon, Camila Paes, additional, Silva, Luiz Eduardo Borges, additional, Bai, Wenlei, additional, Eke, Ibrahim, additional, Rueda, Jose, additional, Carvalho, Leonel, additional, Miranda, Vladimiro, additional, Erlich, Istvan, additional, Theologi, Aimilia‐Myrsini, additional, Asada, Eduardo N., additional, Souza, Aldir S., additional, and Romero, Rubén, additional

Published
2020
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146. Self-Powered Visible–Invisible Multiband Detection and Imaging Achieved Using High-Performance 2D MoTe2/MoS2 Semivertical Heterojunction Photodiodes

Author

Ahn, Jongtae, primary, Kang, Ji-Hoon, additional, Kyhm, Jihoon, additional, Choi, Hyun Tae, additional, Kim, Minju, additional, Ahn, Dae-Hwan, additional, Kim, Dae-Yeon, additional, Ahn, Il-Ho, additional, Park, Jong Bae, additional, Park, Soohyung, additional, Yi, Yeonjin, additional, Song, Jin Dong, additional, Park, Min-Chul, additional, Im, Seongil, additional, and Hwang, Do Kyung, additional

Published
2020
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149. Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites

Author

Kim, Yong, Han, Jung Min, Park, Jong Bae, Lee, Sang Do, Oh, Yong Seok, Chung, Churo, Lee, Taehoon G., Kim, Jae Ho, Park, Seung-Kiel, Yoo, Jong-Shin, Suh, Pann-Ghill, and Ryu, Sung Ho

Subjects
Protein kinases -- Research, Phospholipases -- Research, Biological sciences, Chemistry
Abstract

Protein kinase C (PKC) is an important regulator of phospholipase D1 (PLD1). The controversy regarding a phosphorylation-dependent or -independent mechanism of the activation of PLD1 by PKC was resolved the studying whether PLD1 is phosphorylated by PKC in vivo. Multiple basal phosphopeptides and multiple phorbol myristate acetate induced phosphopeptides of endogenous PLD1 have been identified for the first time in 3Y1 cells as well as of transiently expressed PLD1 in COS-7 cells.

Published
1999

150. Phospholipase D1 in caveolae: regulation by protein kinase C-alpha and caveolin-1

Author

Kim, Jae Ho, Han, Jung Min, Lee, Sukmook, Kim, Yong, Lee, Taehoon G., Park, Jong Bae, Lee, Sang Do, Suh, Pann-Ghill, and Ryu, Sung Ho

Subjects
Fibroblasts -- Research, Phospholipases -- Research, Rats -- Research, Protein kinases -- Research, Biological sciences, Chemistry
Abstract

A study was conducted to show that phospholipase D1 (PLD1) is enriched in the caveolin-enriched membrane (CEM) fraction of 3Y1 rat fibroblasts. A detergent-free process for the purification of a CEm and immunoblot analysis were utilized to carry out the study. Results indicated a novel mechanism for the regulation of the protein kinase C-alpha (PKC-alpha)-dependent PLD activity through the molecular association between PLD1, PKC-alpha and caveolin-1 in caveolae.

Published
1999

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