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103. OC.03.4 INFLIXIMAB THREE-DOSE INDUCTION REGIMEN IN ACUTE SEVERE ULCERATIVE COLITIS: EARLY AND LATE OUTCOME AND PREDICTORS OF COLECTOMY

Author

Monterubbianesi, R., primary, Aratari, A., additional, Armuzzi, A., additional, Daperno, M., additional, Biancone, L., additional, Cappello, M., additional, Annese, V., additional, Riegler, G., additional, Orlando, A., additional, Viscido, A., additional, Meucci, G., additional, Gasbarrini, A., additional, Guidi, L., additional, Lavagna, A., additional, Sostegni, R., additional, Onali, S., additional, Papi, C., additional, and Kohn, A., additional

Published
2014
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104. OC.11.2 CHARACTERIZATION OF INCIDENT CASES OF CANCER IN INFLAMMATORY BOWEL DISEASE PATIENTS: A PROSPECTIVE MULTICENTER CASE-CONTROL IG-IBD STUDY

Author

Biancone, L., primary, Petruzziello, C., additional, Armuzzi, A., additional, Kohn, A., additional, D'Inca, R., additional, Papi, C., additional, Spina, L., additional, Guidi, L., additional, Scribano, M.L., additional, Calabrese, E., additional, Condino, G., additional, Onali, S., additional, Mocciaro, F., additional, Monterubbianesi, R., additional, Alvisi, P., additional, Fries, W., additional, Riegler, G., additional, Castiglione, F., additional, Frankovic, I., additional, Margagnoni, G., additional, Di Mitri, R., additional, Meucci, G., additional, Rogai, F., additional, Orlando, A., additional, Ardizzone, S., additional, and Pallone, F., additional

Published
2014
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108. Adalimumab in active ulcerative colitis: a 'real-life' observational study

Author

Armuzzi, Alessandro, Biancone, L, Daperno, M, Coli, A, Pugliese, D, Annese, V, Aratari, A, Ardizzone, S, Balestrieri, P, Bossa, F, Cappello, M, Castiglione, F, Cicala, M, Danese, S, D'Incà, R, Dulbecco, P, Feliciangeli, G, Fries, W, Genise, S, Gionchetti, P, Gozzi, S, Kohn, A, Lorenzetti, R, Milla, M, Onali, S, Orlando, A, Papparella, Lg, Renna, S, Ricci, C, Rizzello, F, Sostegni, R, Guidi, Luisa, Papi, C., Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), Guidi, Luisa (ORCID:0000-0003-3320-7094), Armuzzi, Alessandro, Biancone, L, Daperno, M, Coli, A, Pugliese, D, Annese, V, Aratari, A, Ardizzone, S, Balestrieri, P, Bossa, F, Cappello, M, Castiglione, F, Cicala, M, Danese, S, D'Incà, R, Dulbecco, P, Feliciangeli, G, Fries, W, Genise, S, Gionchetti, P, Gozzi, S, Kohn, A, Lorenzetti, R, Milla, M, Onali, S, Orlando, A, Papparella, Lg, Renna, S, Ricci, C, Rizzello, F, Sostegni, R, Guidi, Luisa, Papi, C., Armuzzi, Alessandro (ORCID:0000-0003-1572-0118), and Guidi, Luisa (ORCID:0000-0003-3320-7094)

Abstract

The effectiveness of adalimumab in the treatment of ulcerative colitis is under debate. Although controlled trials have shown that adalimumab is significantly better than placebo, the absolute clinical benefit is modest. We report data on the effectiveness of adalimumab in a cohort of ulcerative colitis patients treated in 22 Italian centres.

Published
2013

112. Survival and causes of death in Italian patients with ulcerative colitis

Author

Viscido, A, Bagnardi, B, Sturniolo, Giacomo, Annese, V, Frieri, G, D'Arienzo, A, Papi, C, Riegler, G, Corrao, G, and Caprilli, R.

Subjects
ulcerative colitis mortality, RISK, MALIGNANCY, COLONOSCOPIC SURVEILLANCE, PROGNOSIS, MORTALITY, POPULATION-BASED COHORT, EPIDEMIOLOGY, DECISION-ANALYSIS, ulcerative colitis mortality, INFLAMMATORY-BOWEL-DISEASE, POPULATION-BASED COHORT, COLORECTAL-CANCER, COLONOSCOPIC SURVEILLANCE, DECISION-ANALYSIS, MORTALITY, RISK, PROGNOSIS, EPIDEMIOLOGY, MALIGNANCY, INFLAMMATORY-BOWEL-DISEASE, COLORECTAL-CANCER
Published
2001

113. P445 Infliximab three-dose induction regimen in severe corticosteroid-refractory ulcerative colitis: early and late outcome and predictors of colectomy

Author

Monterubbianesi, R., primary, Aratari, A., additional, Armuzzi, A., additional, Daperno, M., additional, Biancone, L., additional, Cappello, M., additional, Annese, V., additional, Riegler, G., additional, Orlando, A., additional, Viscido, A., additional, Meucci, G.M., additional, Gasbarrini, A., additional, Guidi, L., additional, Lavagna, A., additional, Sostegni, R., additional, Onali, S., additional, Papi, C., additional, and Kohn, A., additional

Published
2014
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114. P542 Crohn's Disease (CD) in the elderly – an IG-IBD study

Author

Viola, A., primary, Cantoro, L., additional, Monterubbianesi, R., additional, Castiglione, F., additional, Principi, M., additional, Frankovic, I., additional, Pugliese, D., additional, Callela, F., additional, Saibeni, S., additional, Aratri, A., additional, Orlando, S., additional, Cappello, M., additional, Costantino, G., additional, Mannetti, N., additional, Mocci, G., additional, Samperi, L., additional, Inserra, G., additional, Privitera, A.C., additional, Caprioli, F., additional, Annese, V., additional, Papi, C., additional, Armuzzi, A., additional, D'Incà, R., additional, Kohn, A., additional, Manguso, F., additional, and Fries, W., additional

Published
2014
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116. P303 Ulcerative colitis (UC) in the elderly – Moderate at onset but then a milder course? An IG-IBD study

Author

Fries, W., primary, Viola, A., additional, Mannetti, N., additional, Coppola, M., additional, Frankovic, I., additional, Monterubbianesi, R., additional, Cantoro, L., additional, Pugliese, D., additional, Aratri, A., additional, Cappello, M., additional, Saibeni, S., additional, Principi, M., additional, Naccarato, P., additional, Mocci, G., additional, Castiglione, F., additional, Callela, F., additional, Magarotto, A., additional, Caprioli, F., additional, Belvedere, A., additional, Casella, G., additional, Samperi, L., additional, Privitera, A.C., additional, Inserra, G., additional, Danese, S., additional, Papi, C., additional, Armuzzi, A., additional, Kohn, A., additional, D'Incà, R., additional, Annese, V., additional, and Manguso, F., additional

Published
2014
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117. DOP093 Characterisation of incident cases of cancer in inflammatory bowel disease: A prospective multicenter matched-pair IG-IBD study

Author

Biancone, L., primary, Petruzziello, C., additional, Armuzzi, A., additional, Scribano, M.L., additional, D'Incà, R., additional, Papi, C., additional, Spina, L., additional, Guidi, L., additional, Kohn, A., additional, Calabrese, E., additional, Condino, G., additional, Onali, S., additional, Mocciaro, F., additional, Monterubbianesi, R., additional, Alvisi, P., additional, Fries, W., additional, Riegler, G., additional, Castiglione, F., additional, Frankovic, I., additional, Margagnoni, G., additional, Di Mitri, R., additional, Meucci, G., additional, Rogai, F., additional, Ardizzone, S., additional, Orlando, A., additional, and Pallone, F., additional

Published
2014
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119. Hepatobiliary alterations in patients with inflammatory bowel disease: a multicenter study

Author

Riegler, G, D'Inca, R., Sturniolo, Giacomo, Corrao, G., DEL VECCHIO BLANCO, C., DI LEO, V., Carratu, R., Ingrosso, M., Pelli, M. A., Morini, S., Valpiani, D., Cantarini, D., Usai, P., Papi, C., Caprilli, R., and Sturniolo, G.

Subjects
Crohn's disease, MANIFESTATIONS, ULCERATIVE-COLITIS, DISORDERS, GALLSTONES, Crohn's disease, gallstones, liver enzymes, ulcerative colitis, ultrasonography, PRIMARY SCLEROSING CHOLANGITIS, ULCERATIVE-COLITIS, CROHNS-DISEASE, GALL-STONES, PREVALENCE, MANIFESTATIONS, GALLSTONES, DISORDERS, ultrasonography, PRIMARY SCLEROSING CHOLANGITIS, GALL-STONES, CROHNS-DISEASE, ulcerative colitis, liver enzymes, PREVALENCE
Published
1998

120. OC.11.3 EARLY POST-OPERATIVE ENDOSCOPIC RECURRENCE IN CROHN'S DISEASE: DATA FROM A LARGE PROSPECTIVE ITALIAN MULTICENTER COHORT (AN IG-IBD STUDY)

Author

Orlando, A., primary, Mocciaro, F., additional, Scimeca, D., additional, Rispo, A., additional, Scribano, M.L., additional, Testa, A., additional, Aratari, A., additional, Bossa, F., additional, Tambasco, R., additional, Angelucci, E., additional, Onali, S., additional, Cappello, M., additional, Fries, W., additional, D'Incà, R., additional, Martinato, M., additional, Castiglione, F., additional, Papi, C., additional, Annese, V., additional, Gionchetti, P., additional, Rizzello, F., additional, Vernia, P., additional, Biancone, L., additional, Kohn, A., additional, and Cottone, M., additional

Published
2013
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122. P.02.9 INCIDENT CASES OF CANCER IN IBD: CLINICAL CHARACTERISTICS OF IBD VS IMMUNOMODULATORS IN A PROSPECTIVE MULTICENTER CASE-CONTROL STUDY

Author

Petruzziello, C., primary, Armuzzi, A., additional, Kohn, A., additional, D'Incà, R., additional, Papi, C., additional, Spina, L., additional, Guidi, L., additional, Scribano, M.L., additional, Onali, S., additional, Condino, G., additional, Calabrese, E., additional, Monterubbianesi, R., additional, Alvisi, P., additional, Fries, W., additional, Riegler, G., additional, Margagnoni, G., additional, Meucci, G.M., additional, Rogai, F., additional, Pallone, F., additional, and Biancone, L., additional

Published
2013
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124. P292 Clinical characteristics of inflammatory bowel disease may influence the cancer risk when using immunomodulators: incident cases of cancer in a multicenter case-control study

Author

Petruzziello, C., primary, Armuzzi, A., additional, Kohn, A., additional, D'Incà, R., additional, Papi, C., additional, Spina, L., additional, Guidi, L., additional, Scribano, M.L., additional, Onali, S., additional, Condino, G., additional, Calabrese, E., additional, Monterubbianesi, R., additional, Alvisi, P., additional, Fries, W., additional, Riegler, G., additional, Castiglione, F., additional, Margagnoni, G., additional, Meucci, G., additional, Rogai, F., additional, Pallone, F., additional, and Biancone, L., additional

Published
2013
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126. OC.12.3 EARLY POST-OPERATIVE ENDOSCOPIC RECURRENCE IN CROHN'S DISEASE IN A LARGE PROSPECTIVE ITALIAN MULTICENTER COHORT

Author

Orlando, A., primary, Mocciaro, F., additional, Scimeca, D., additional, Rispo, A., additional, Scribano, M.L., additional, Testa, A., additional, Aratari, A., additional, Bossa, F., additional, Tambasco, R., additional, Angelucci, E., additional, Onali, S., additional, Cappello, M., additional, Fries, W., additional, D'Incà, R., additional, Martinato, M., additional, Castiglione, F., additional, Papi, C., additional, Annese, V., additional, Gionchetti, P., additional, Rizzello, F., additional, Vernia, P., additional, Biancone, L., additional, Perricone, G., additional, Kohn, A., additional, and Cottone, M., additional

Published
2012
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128. OC.06.3 ADALIMUMAB IN ACTIVE ULCERATIVE COLITIS: A “REAL-LIFE” OBSERVATIONAL STUDY

Author

Armuzzi, A., primary, Biancone, L., additional, Daperno, M., additional, Coli, A., additional, Annese, V., additional, Ardizzone, S., additional, Balestrieri, P., additional, Bossa, F., additional, Castiglione, F., additional, Cicala, M., additional, Danese, S., additional, D'Incà, R., additional, Dulbecco, P., additional, Feliciangeli, G., additional, Fries, W., additional, Genise, S., additional, Gionchetti, P., additional, Gozzi, S., additional, Kohn, A., additional, Lorenzetti, R., additional, Milla, M., additional, Onali, S., additional, Orlando, A., additional, Papparella, L.G., additional, Pugliese, D., additional, Renna, S., additional, Ricci, C., additional, Rizzello, F., additional, Sostegni, R., additional, Guidi, L., additional, and Papi, C., additional

Published
2012
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129. P230 Adalimumab in active ulcerative colitis: A “real-life” observational study

Author

Armuzzi, A., primary, Biancone, L., additional, Daperno, M., additional, Coli, A., additional, Annese, V., additional, Ardizzone, S., additional, Balestrieri, P., additional, Bossa, F., additional, Castiglione, F., additional, Cicala, M., additional, Danese, S., additional, D'Incà, R., additional, Dulbecco, P., additional, Feliciangeli, G., additional, Fries, W., additional, Genise, S., additional, Gionchetti, P., additional, Gozzi, S., additional, Kohn, A., additional, Lorenzetti, R., additional, Milla, M., additional, Onali, S., additional, Orlando, A., additional, Papparella, L.G., additional, Pugliese, D., additional, Renna, S., additional, Ricci, C., additional, Rizzello, F., additional, Sostegni, R., additional, Guidi, L., additional, and Papi, C., additional

Published
2012
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131. Two mesalazine regimens in the prevention of the post-operative recurrence of Crohn's disease: A pragmatic, double-blind, randomized controlled trial

Author

Caprilli, R, Cottone, M, Tonelli, F, Sturniolo, G, Castiglione, F, Annese, V, Papi, C, Viscido, A, Cammà, C, Corrao, G, Latella, G, CORRAO, GIOVANNI, Latella, G., Caprilli, R, Cottone, M, Tonelli, F, Sturniolo, G, Castiglione, F, Annese, V, Papi, C, Viscido, A, Cammà, C, Corrao, G, Latella, G, CORRAO, GIOVANNI, and Latella, G.

Abstract

BACKGROUND: The role of mesalazine in preventing the clinical recurrence of Crohn's disease after surgery has been shown in a meta-analysis of all published studies. No clear relationship, however, has been shown between dosage and response. AIM: To evaluate whether 4.0 g/day of mesalazine may offer therapeutic advantages over 2.4 g/day in the prevention of both endoscopic and clinical post-operative recurrence of Crohn's disease. METHODS: The study was a double-blind, randomized, multi-centre, prospective, controlled clinical trial. Two hundred and six patients, submitted to first or second intestinal resection for Crohn's disease limited to the terminal ileum, with or without involvement of the caecum/ascending colon, were enrolled. Of these, 101 were randomly allocated to receive 4.0 g/day of mesalazine (Asacol, Giuliani SpA, Milan, Italy) and 105 to receive 2.4 g/day, starting 2 weeks after surgery. The primary outcome was endoscopic recurrence, at 12 months after surgery. Three different degrees of endoscopic recurrence were evaluated (endoscopic scores: > 0, > 1 and > 2). The secondary outcome was clinical recurrence, defined as a Crohn's disease activity index of more than 150 points or an increase in the Crohn's disease activity index of 100 points or more. For statistical analysis, chi-square, Wilcoxon and Cox regression model tests were used, when appropriate. RESULTS: Eighty-four patients in the 4.0 g/day group and 81 patients in the 2.4 g/day group were evaluable by endoscopy. Endoscopic recurrence of > 0 was significantly higher in the 2.4 g/day group than in the 4.0 g/day group (62% vs. 46%; P < 0.04). No difference was observed between the two groups with regard to the other two endoscopic outcomes (> 1 and > 2) or clinical recurrence. CONCLUSIONS: A 4.0 g/day regimen of mesalazine does not offer a clinically significant advantage over a 2.4 g/day regimen in the prevention of post-operative endoscopic and clinical recurrence of Crohn's disease at 1 ye

Published
2003

133. P.80 INFLIXIMAB FOR SEVERE ULCERATIVE COLITIS: SHORT-TERM AND ONE YEAR OUTCOME OF THREE DOSE REGIMEN. AN ITALIAN MULTICENTRE OPEN-LABEL STUDY

Author

Monterubbianesi, R., primary, Daperno, M., additional, Armuzzi, A., additional, Biancone, L., additional, Cappello, M., additional, Lavagna, A., additional, Annese, V., additional, Orlando, A., additional, Viscido, A., additional, Riegler, G., additional, Meucci, G., additional, Papi, C., additional, Sostegni, R., additional, Guidi, M., additional, Gasbarrini, A., additional, Petruzziello, C., additional, Peralta, S., additional, Aratari, A., additional, Prantera, C., additional, and Kohn, A., additional

Published
2010
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134. OC.01.4 EARLY POST-OPERATIVE ENDOSCOPIC RECURRENCE IN CROHN'S DISEASE IN AN ITALIAN MULTICENTRIC COHORT

Author

Orlando, A., primary, Scimeca, D., additional, Mocciaro, F., additional, Testa, A., additional, Aratari, A., additional, Bossa, F., additional, Tambasco, R., additional, Angelucci, E., additional, Onali, S., additional, Cappello, M., additional, Fries, W., additional, D'Incà, R., additional, Castiglione, F., additional, Papi, C., additional, Annese, V., additional, Gionchetti, P., additional, Vernia, P., additional, Biancone, L., additional, and Cottone, M., additional

Published
2010
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136. P.71 ANTI-TNF THERAPY IN ELDERLY PEOPLE IN IBD: AN ITALIAN MULTICENTRE SURVEY

Author

Cottone, M., primary, Kohn, A., additional, Daperno, M., additional, Armuzzi, A., additional, Guidi, L., additional, D'Incà, R., additional, Bossa, F., additional, Biancone, L., additional, Gionchetti, P., additional, Ardizzone, S., additional, Papi, C., additional, Fries, W., additional, Danese, S., additional, Cappello, M., additional, and Orlando, A., additional

Published
2010
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139. NEWLY DIAGNOSED NEOPLASIA IN A COHORT OF CROHN'S DISEASE PATIENTS TREATED OR UNTREATED WITH INFLIXIMAB FOLLOWED UP IN THE LONG TERM: A MULTICENTER MATCHED-PAIR STUDY

Author

Petruzziello, C., primary, Orlando, A., additional, Kohn, A., additional, Ardizzone, S., additional, Daperno, M., additional, Angelucci, E., additional, Castiglione, F., additional, D'Incà, R., additional, Papi, C., additional, Meucci, G., additional, Riegler, G., additional, Sica, G., additional, Rizzello, F., additional, Mocciaro, F., additional, Onali, S., additional, Calabrese, E., additional, Cottone, M., additional, Pallone, F., additional, and Biancone, L., additional

Published
2009
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141. P161 - Newly diagnosed neoplasia in a cohort of Crohn's disease patients treated or untreated with infliximab followed up in the long term: a multicenter matched-pair study

Author

Biancone, L., primary, Orlando, A., additional, Kohn, A., additional, Ardizzone, S., additional, Angelucci, E., additional, Castiglione, F., additional, D'Incà, R., additional, Papi, C., additional, Meucci, G., additional, Riegler, G., additional, Petruzziello, C., additional, Rizzello, F., additional, Mocciaro, F., additional, Onali, S., additional, Calabrese, E., additional, Cottone, M., additional, and Pallone, F., additional

Published
2009
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144. Survival and causes of death in Italian patients with ulcerative colitis. A GISC nation-wide study

Author

Viscido, A, Bagnardi, V, Sturniolo, G, Annese, V, Frieri, G, D'Arienzo, A, Papi, C, Riegler, G, Corrao, G, Caprilli, R, Sturniolo, GC, Caprilli, R., BAGNARDI, VINCENZO, CORRAO, GIOVANNI, Viscido, A, Bagnardi, V, Sturniolo, G, Annese, V, Frieri, G, D'Arienzo, A, Papi, C, Riegler, G, Corrao, G, Caprilli, R, Sturniolo, GC, Caprilli, R., BAGNARDI, VINCENZO, and CORRAO, GIOVANNI

Abstract

BACKGROUND: Death rate for patients with ulcerative colitis has changed over last few decades. Recent studies indicate that cumulative long-term mortality is comparable to that in general population, and that deaths may depend on causes not strictly related to colonic disease. AIM: To evaluate overall and cause-specific mortality rate in a large group of Italian patients with ulcerative colitis. METHODS: A total of 2,066 ulcerative colitis patients aged >18 years consecutively diagnosed in twenty Italian Gastroenterology Units between 1964 and 1995 were followed-up from diagnosis until 1997. Standardised Mortality Ratios and Relative Survival Ratios were calculated. RESULTS: Overall mortality of patients with ulcerative colitis was comparable to that in general population with 93 deaths observed versus 92.1 expected (standardises mortality ratio, 1.0; 95% confidence interval, 0.8-1.2). Significantly higher mortality was observed in patients under 30 years of age at diagnosis (standardised mortality ratio, 2.7; 95% confidence interval, 1.3-4.9), and in those diagnosed before 1974 (standardised mortality ratio, 2.7; 95% confidence interval, 1.1-5.7). Proctocolitis and complications from surgery were mentioned in 11 and 5 certificates, respectively. A significant excess of deaths was observed for colorectal cancer (colon: standardised mortality ratio, 3.0; 95% confidence interval, 1.0-6.9; rectum: standardised mortality ratio, 4.4; 95% confidence interval, 1.2-11.3), and haemolymphopoietic neoplasms (standardised mortality ratio, 2.8; 95% confidence interval, 1.0-6.1), in particular multiple myeloma and non-Hodgkin lymphoma. A significant deficit of deaths was observed for cancer of the respiratory system (standardised mortality ratio, 0.3; 95% confidence interval, 0.1-1.0). CONCLUSIONS: This study confirms that, also in Italy, mortality of patients with ulcerative colitis is comparable to that in general population. Only 12% of deaths were due to ulcerative colitis it

Published
2001

147. PA.149 USE OF ALTERNATIVE AND COMPLEMENTARY MEDICINE IN ITALIAN PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Author

D'Incà, R., primary, Bertomoro, P., additional, Garribba, A.T., additional, Pastorelli, L., additional, Bortoli, A., additional, Vecchi, M., additional, Ferraris, L., additional, Di Paolo, M.C., additional, Renna, S., additional, Tipaldi, C., additional, Castiglione, F., additional, Bossa, F., additional, Annese, V., additional, Cottone, M., additional, Angelucci, E., additional, Cassieri, C., additional, Casella, G., additional, Fazi, M., additional, Kohn, A., additional, Fries, W., additional, Papi, C., additional, Meucci, G., additional, and Principi, B., additional

Published
2008
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148. OC1.08.6 NEWLY DIAGNOSED CANCER IN A COHORT OF CROHN'S DISEASE PATIENTS TREATED WITH INFLIXIMAB: A 3 YEARS LONGER FOLLOW UP FROM A MULTICENTER MATCHED-PAIR STUDY

Author

Biancone, L., primary, Orlando, A., additional, Kohn, A., additional, Ardizzone, S., additional, Daperno, M., additional, Angelucci, E., additional, Castiglione, F., additional, D'Incà, R., additional, Papi, C., additional, Meucci, G.M., additional, Riegler, G., additional, Petruzziello, C., additional, Mocciaro, F., additional, Onali, S., additional, Calabrese, E., additional, Cottone, M., additional, and Pallone, F., additional

Published
2008
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