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2,058 results on '"Pandey, Ambarish"'

105. Trajectory of C-Reactive Protein and Incident Heart Failure in Black Adults: The Jackson Heart Study.

Author

Hamid, Arsalan, Yimer, Wondwosen K., Oshunbade, Adebamike A., Khan, Muhammad Shahzeb, Daisuke Kamimura, Kipchumba, Rodney K., Pandey, Ambarish, Clark III, Donald, Mentz, Robert J., Fox, Ervin R., Berry, Jarett D., Stacey, R. Brandon, Shah, Amil, Correa, Adolfo, Virani, Salim S., Butler, Javed, and Hall, Michael E.

Abstract

BACKGROUND: Increased hsCRP (high-sensitivity C-reactive protein), a marker of inflammation, is associated with incident cardiovascular events. We aim to determine whether the baseline or trajectory of hsCRP levels over time predicts incident heart failure (HF) hospitalization. METHODS: JHS (Jackson Heart Study) participants' (n=3920 Black adults) hsCRP levels were measured over 3 visits (from 2000 to 2013). We assessed the association of hsCRP at baseline (visit 1) with incident HF hospitalization using Cox proportional hazards models. Furthermore, we assessed the association of the trajectory of hsCRP over repeated measurements (visits 1-3) with incident HF using joint models. Hazard ratios are reflective of an increase in hsCRP by 1 SD on a log2 scale. We also assessed the association of change in hsCRP between visit 1 and visit 3 with Cox proportional hazards models by grouping patients by low (<2 mg/L) and high (=2 mg/L) hsCRP levels. The 4 groups were low-to-low (referent), low-to-high, high-to-low, and high-to-high. RESULTS: Mean baseline age of participants was 54±13 years, and 63.8% were women. Over a median follow-up of 12 years, 308 (7.9%) participants were hospitalized with incident HF. Baseline hsCRP was not associated with incident HF (adjusted hazard ratio, 1.08 [95% CI, 0.96-1.22]). However, increasing hsCRP levels over repeated measures were associated with a higher risk of incident HF overall (adjusted hazard ratio, 1.22 [95% CI, 1.03-1.44]) and HF with preserved ejection fraction (adjusted hazard ratio, 1.30 [95% CI, 1.02-1.65]) but not HF with reduced ejection fraction (P>0.05). Furthermore, changes in hsCRP from low-to-high and high-to-low levels were associated with incident HF (P<0.05). CONCLUSIONS: While baseline hsCRP was not associated with incident HF, an increasing trajectory of hsCRP over time was associated with increased risk for incident HF (particularly HF with preserved ejection fraction). Temporal change in hsCRP may be an important marker of risk for incident HF with preserved ejection fraction in Black adults. [ABSTRACT FROM AUTHOR]

Published
2024
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109. Sex and Race Differences in Lifetime Risk of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction

Author

Pandey, Ambarish, Omar, Wally, Ayers, Colby, LaMonte, Michael, Klein, Liviu, Allen, Norrina B, Kuller, Lewis H, Greenland, Philip, Eaton, Charles B, Gottdiener, John S, Lloyd-Jones, Donald M, and Berry, Jarett D

Subjects
Cardiovascular, Heart Disease, Prevention, Clinical Research, Heart Disease - Coronary Heart Disease, Aging, Patient Safety, Good Health and Well Being, African Americans, Age Factors, Aged, Aged, 80 and over, Female, Heart Failure, Hispanic or Latino, Humans, Incidence, Male, Middle Aged, Myocardial Infarction, Prognosis, Prospective Studies, Racial Groups, Risk Assessment, Risk Factors, Sex Factors, Stroke Volume, Time Factors, United States, Ventricular Function, Left, Whites, heart failure, risk, White People, Black or African American, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

BackgroundLifetime risk of heart failure has been estimated to range from 20% to 46% in diverse sex and race groups. However, lifetime risk estimates for the 2 HF phenotypes, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF), are not known.MethodsParticipant-level data from 2 large prospective cohort studies, the CHS (Cardiovascular Health Study) and MESA (Multiethnic Study of Atherosclerosis), were pooled, excluding individuals with prevalent HF at baseline. Remaining lifetime risk estimates for HFpEF (EF ≥45%) and HFrEF (EF 45 years of age (22.2% blacks, 44.8% men) who were followed up for median duration of 11.6 years with 2178 overall incident HF events with 561 HFrEF events and 726 HFpEF events. At the index age of 45 years, the lifetime risk for any HF through 90 years of age was higher in men than women (27.4% versus 23.8%). Among HF subtypes, the lifetime risk for HFrEF was higher in men than women (10.6% versus 5.8%). In contrast, the lifetime risk for HFpEF was similar in men and women. In race-stratified analyses, lifetime risk for overall HF was higher in nonblacks than blacks (25.9% versus 22.4%). Among HF subtypes, the lifetime risk for HFpEF was higher in nonblacks than blacks (11.2% versus 7.7%), whereas that for HFrEF was similar across the 2 groups. Among participants with antecedent myocardial infarction before HF diagnosis, the remaining lifetime risks for HFpEF and HFrEF were up to 2.5-fold and 4-fold higher, respectively, compared with those without antecedent myocardial infarction.ConclusionsLifetime risks for HFpEF and HFrEF vary by sex, race, and history of antecedent myocardial infarction. These insights into the distribution of HF risk and its subtypes could inform the development of targeted strategies to improve population-level HF prevention and control.

Published
2018

112. Effect of liraglutide on thigh muscle fat and muscle composition in adults with overweight or obesity: Results from a randomized clinical trial

Author

Pandey, Ambarish, primary, Patel, Kershaw V., additional, Segar, Matthew W., additional, Ayers, Colby, additional, Linge, Jennifer, additional, Leinhard, Olof D., additional, Anker, Stefan D., additional, Butler, Javed, additional, Verma, Subodh, additional, Joshi, Parag H., additional, and Neeland, Ian J., additional

Published
2024
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113. Association between dietary phosphate intake and skeletal muscle energetics in adults without cardiovascular disease

Author

Giacona, John M., primary, Afridi, Areeb, additional, Bezan Petric, Ursa, additional, Johnson, Talon, additional, Pastor, Johanne, additional, Ren, Jimin, additional, Sandon, Lona, additional, Malloy, Craig, additional, Pandey, Ambarish, additional, Shah, Amil, additional, Berry, Jarett D., additional, Moe, Orson W., additional, and Vongpatanasin, Wanpen, additional

Published
2024
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114. Temporal Trends and Racial/Ethnic- and Sex-Differences in LDL Cholesterol Control Among US Adults with Self-Reported Atherosclerotic Cardiovascular Disease

Author

Nguyen, Danh Q, primary, Keshvani, Neil, additional, Chandra, Alvin, additional, Alebna, Pamela L., additional, Dixon, Dave L., additional, Shapiro, Michael D., additional, Michos, Erin D., additional, Sperling, Laurence S., additional, Pandey, Ambarish, additional, and Mehta, Anurag, additional

Published
2024
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115. Association of diabetes‐specific heart failure risk score with presence of subclinical cardiomyopathy among individuals with diabetes: A prospective study

Author

Chunawala, Zainali S., primary, Keshvani, Neil, additional, Segar, Matthew W., additional, Patel, Kershaw V., additional, Usman, Muhammad Shariq, additional, Subramanian, Vinayak, additional, Raygor, Viraj, additional, Chandra, Alvin, additional, Khan, Muhammad Shahzeb, additional, and Pandey, Ambarish, additional

Published
2024
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135. Abstract 14862: Development and Validation of a Phenomapping Tool to Identify Patients With Diuretic Resistance in Acute Decompensated Heart Failure: A Multi-Cohort Analysis

Author

Segar, Matthew W, Khan, Mohammad S, Patel, Kershaw, Butler, Javed, Ravichandran, Ashwin, Ravichandran, Ashwin, Walsh, Mary N, Willett, Duwayne, Fonarow, Gregg C, Drazner, Mark H, Mentz, Robert J, Hall, Jennifer L, Farr, MaryJane, Hedayati, Susan, Yancy, Clyde W, Allen, Larry A, Tang, Wai Hong W, and Pandey, Ambarish

Published
2022
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150. Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure

Author

Pandey, Ambarish, LaMonte, Michael, Klein, Liviu, Ayers, Colby, Psaty, Bruce M, Eaton, Charles B, Allen, Norrina B, de Lemos, James A, Carnethon, Mercedes, Greenland, Philip, and Berry, Jarett D

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Heart Disease, Cardiovascular, Prevention, Aging, Aged, Body Mass Index, Cohort Studies, Exercise, Female, Heart Failure, Humans, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Stroke Volume, body mass index, dose-response relationship, heart failure, physical activity, dose–response relationship, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundLower leisure-time physical activity (LTPA) and higher body mass index (BMI) are independently associated with risk of heart failure (HF). However, it is unclear if this relationship is consistent for both heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF).ObjectivesThis study sought to quantify dose-response associations between LTPA, BMI, and the risk of different HF subtypes.MethodsIndividual-level data from 3 cohort studies (WHI [Women's Health Initiative], MESA [Multi-Ethnic Study of Atherosclerosis], and CHS [Cardiovascular Health Study]) were pooled and participants were stratified into guideline-recommended categories of LTPA and BMI. Associations between LTPA, BMI, and risk of overall HF, HFpEF (ejection fraction ≥45%), and HFrEF (ejection fraction 1,000 MET-min/week) were associated with an 19% lower risk of HFpEF (hazard ratio: 0.81; 95% confidence interval: 0.68 to 0.97). The dose-response relationship for BMI with HFpEF risk was also more consistent than with HFrEF risk, such that increasing BMI above the normal range (≥25 kg/m2) was associated with a greater increase in risk of HFpEF than HFrEF.ConclusionsOur study findings show strong, dose-dependent associations between LTPA levels, BMI, and risk of overall HF. Among HF subtypes, higher LTPA levels and lower BMI were more consistently associated with lower risk of HFpEF compared with HFrEF.

Published
2017

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