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102. Clinical advances in obsessive-compulsive disorder: a position statement by the International College of Obsessive-Compulsive Spectrum Disorders

Author

Fineberg, Naomi A, Hollander, Eric, Pallanti, Stefano, Walitza, Susanne, Grünblatt, Edna, Dell'Osso, Bernardo Maria, Albert, Umberto, Geller, Daniel A, Brakoulias, Vlasios, Janardhan Reddy, Y C, Arumugham, Shyam Sundar, Shavitt, Roseli G, Drummond, Lynne, Grancini, Benedetta, De Carlo, Vera, Cinosi, Eduardo, Chamberlain, Samuel R, Ioannidis, Konstantinos, Rodriguez, Carolyn I, Garg, Kabir, Castle, David, Van Ameringen, Michael, Stein, Dan J, Carmi, Lior, Zohar, Joseph, Menchon, Jose M, Fineberg, Naomi A, Hollander, Eric, Pallanti, Stefano, Walitza, Susanne, Grünblatt, Edna, Dell'Osso, Bernardo Maria, Albert, Umberto, Geller, Daniel A, Brakoulias, Vlasios, Janardhan Reddy, Y C, Arumugham, Shyam Sundar, Shavitt, Roseli G, Drummond, Lynne, Grancini, Benedetta, De Carlo, Vera, Cinosi, Eduardo, Chamberlain, Samuel R, Ioannidis, Konstantinos, Rodriguez, Carolyn I, Garg, Kabir, Castle, David, Van Ameringen, Michael, Stein, Dan J, Carmi, Lior, Zohar, Joseph, and Menchon, Jose M

Abstract

In this position statement, developed by The International College of Obsessive-Compulsive Spectrum Disorders, a group of international experts responds to recent developments in the evidence-based management of obsessive-compulsive disorder (OCD). The article presents those selected therapeutic advances judged to be of utmost relevance to the treatment of OCD, based on new and emerging evidence from clinical and translational science. Areas covered include refinement in the methods of clinical assessment, the importance of early intervention based on new staging models and the need to provide sustained well-being involving effective relapse prevention. The relative benefits of psychological, pharmacological and somatic treatments are reviewed and novel treatment strategies for difficult to treat OCD, including neurostimulation, as well as new areas for research such as problematic internet use, novel digital interventions, immunological therapies, pharmacogenetics and novel forms of psychotherapy are discussed.

Published
2020

107. Expert appraisal of criteria for assessing gaming disorder: an international Delphi study

Author

Castro‐Calvo, Jesús, primary, King, Daniel L., additional, Stein, Dan J., additional, Brand, Matthias, additional, Carmi, Lior, additional, Chamberlain, Samuel R., additional, Demetrovics, Zsolt, additional, Fineberg, Naomi A., additional, Rumpf, Hans‐Jürgen, additional, Yücel, Murat, additional, Achab, Sophia, additional, Ambekar, Atul, additional, Bahar, Norharlina, additional, Blaszczynski, Alexander, additional, Bowden‐Jones, Henrietta, additional, Carbonell, Xavier, additional, Chan, Elda Mei Lo, additional, Ko, Chih‐Hung, additional, de Timary, Philippe, additional, Dufour, Magali, additional, Grall‐Bronnec, Marie, additional, Lee, Hae Kook, additional, Higuchi, Susumu, additional, Jimenez‐Murcia, Susana, additional, Király, Orsolya, additional, Kuss, Daria J., additional, Long, Jiang, additional, Müller, Astrid, additional, Pallanti, Stefano, additional, Potenza, Marc N., additional, Rahimi‐Movaghar, Afarin, additional, Saunders, John B., additional, Schimmenti, Adriano, additional, Lee, Seung‐Yup, additional, Siste, Kristiana, additional, Spritzer, Daniel T., additional, Starcevic, Vladan, additional, Weinstein, Aviv M., additional, Wölfling, Klaus, additional, and Billieux, Joël, additional

Published
2021
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112. Body dysmorphic disorder: a treatment synthesis and consensus on behalf of the International College of Obsessive-Compulsive Spectrum Disorders and the Obsessive Compulsive and Related Disorders Network of the European College of Neuropsychopharmacology

Author

Castle, David, primary, Beilharz, Francesca, additional, Phillips, Katharine A., additional, Brakoulias, Vlasios, additional, Drummond, Lynne M., additional, Hollander, Eric, additional, Ioannidis, Konstantinos, additional, Pallanti, Stefano, additional, Chamberlain, Samuel R., additional, Rossell, Susan L., additional, Veale, David, additional, Wilhelm, Sabine, additional, Van Ameringen, Michael, additional, Dell’Osso, Bernardo, additional, Menchon, Jose M., additional, and Fineberg, Naomi A., additional

Published
2020
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115. Suicidal ideation and suicidal attempts in patients with obsessive-compulsive tic-related disorder vs obsessive-compulsive disorder: results of a multicenter Italian study

Author

Benatti, Beatrice, primary, Ferrari, Silvia, additional, Grancini, Benedetta, additional, Girone, Nicolaja, additional, Briguglio, Matteo, additional, Marazziti, Donatella, additional, Mucci, Federico, additional, Dell’Osso, Liliana, additional, Gambini, Orsola, additional, Demartini, Benedetta, additional, Tundo, Antonio, additional, Necci, Roberta, additional, De Berardis, Domenico, additional, Galentino, Roberta, additional, De Michele, Sara, additional, Albert, Umberto, additional, Rigardetto, Sylvia, additional, Maina, Giuseppe, additional, Grassi, Giacomo, additional, Pallanti, Stefano, additional, Amerio, Andrea, additional, Amore, Mario, additional, Priori, Alberto, additional, Servello, Domenico, additional, Viganò, Caterina, additional, Bosi, Monica, additional, Colombo, Anna, additional, Porta, Mauro, additional, and Dell’Osso, Bernardo, additional

Published
2020
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116. A transdiagnostic perspective of constructs underlying obsessive-compulsive and related disorders: An international Delphi consensus study

Author

Fontenelle, Leonardo F, primary, Oldenhof, Erin, additional, Eduarda Moreira-de-Oliveira, Maria, additional, Abramowitz, Jonathan S, additional, Antony, Martin M, additional, Cath, Danielle, additional, Carter, Adrian, additional, Dougherty, Darin, additional, Ferrão, Ygor A, additional, Figee, Martijn, additional, Harrison, Ben J, additional, Hoexter, Marcelo, additional, Soo Kwon, Jun, additional, Küelz, Anne, additional, Lazaro, Luísa, additional, Lochner, Christine, additional, Marazziti, Donatella, additional, Mataix-Cols, David, additional, McKay, Dean, additional, Miguel, Euripedes C, additional, Morein-Zamir, Sharon, additional, Moritz, Steffen, additional, Nestadt, Gerald, additional, O’Connor, Kieron, additional, Pallanti, Stefano, additional, Purdon, Christine, additional, Rauch, Scott, additional, Richter, Peggy, additional, Rotge, Jean-Yves, additional, Shavitt, Roseli G, additional, Soriano-Mas, Carles, additional, Starcevic, Vladan, additional, Stein, Dan J, additional, Steketee, Gail, additional, Storch, Eric A, additional, Taylor, Steven, additional, van den Heuvel, Odile A, additional, Veale, David, additional, Woods, Douglas W, additional, Verdejo-Garcia, Antonio, additional, and Yücel, Murat, additional

Published
2020
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135. Transcranial magnetic stimulation in the treatment of obsessive–compulsive disorder: current perspectives

Author

Lusicic,Ana, Schruers,Koen RJ, Pallanti,Stefano, and Castle,David J

Subjects
Neuropsychiatric Disease and Treatment, mental disorders, behavioral disciplines and activities
Abstract

Ana Lusicic,1 Koen RJ Schruers,2 Stefano Pallanti,3,4 David J Castle5,6 1PACE Clinic, Orygen Youth Health, Melbourne, VIC, Australia; 2Research Institute for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands; 3Institute of Neurosciences, Florence, Italy; 4Stanford University, Palo Alto, CA, USA; 5St Vincent’s Hospital, 6University of Melbourne, Melbourne, VIC, Australia Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neurostimulation technique receiving increasing attention in the treatment of different psychiatric disorders. Evidence for rTMS use in obsessive–compulsive disorder (OCD) is accumulating and informing further developments in the neurostimulation field, the latest being deep transcranial magnetic stimulation (dTMS). dTMS allows direct stimulation of deeper subcortical structures and larger brain volume than conventional rTMS. Underlying neurobiological mechanisms related to transcranial magnetic stimulation are still under evaluation, but appear to offer a novel “third” way of addressing symptoms via localized electrical stimulation compared to pharmacotherapy and psychotherapy approaches. This systematic review focuses on the effects of rTMS and dTMS stimulation on different brain targets in OCD. Brain areas included are the dorsolateral prefrontal cortex, supplementary motor area, orbitofrontal cortex/medial prefrontal cortex, and anterior cingulate cortex (ACC). Improved understanding of the therapeutic effects of rTMS in OCD will support fine-tuning of the method and help determine how we can best optimize the approach via rTMS or dTMS to achieve clinically relevant results. Keywords: repetitive transcranial magnetic stimulation, rTMS, deep TMS, obsessive–compulsive disorder, OCD, noninvasive neurostimulation

Published
2018

138. Lifetime bipolar disorder comorbidity and related clinical characteristics in patients with primary obsessive compulsive disorder: a report from the International College of Obsessive–Compulsive Spectrum Disorders (ICOCS)

Author

Dell’Osso, Bernardo, primary, Vismara, Matteo, additional, Benatti, Beatrice, additional, Cirnigliaro, Giovanna, additional, Grancini, Benedetta, additional, Fineberg, Naomi A., additional, Van Ameringen, Michael, additional, Hollander, Eric, additional, Stein, Dan J., additional, Menchon, Josè M., additional, Rodriguez, Carolyn I., additional, Nicolini, Humberto, additional, Lanzagorta, Nuria, additional, Pallanti, Stefano, additional, Grassi, Giacomo, additional, Lochner, Christine, additional, Marazziti, Donatella, additional, Hranov, Georgi, additional, Karamustafalioglu, Oguz, additional, Hranov, Luchezar, additional, and Zohar, Joseph, additional

Published
2019
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143. European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD

Author

Kooij Sandra JJ, Bejerot Susanne, Blackwell Andrew, Caci Herve, Casas-Brugué Miquel, Carpentier Pieter J, Edvinsson Dan, Fayyad John, Foeken Karin, Fitzgerald Michael, Gaillac Veronique, Ginsberg Ylva, Henry Chantal, Krause Johanna, Lensing Michael B, Manor Iris, Niederhofer Helmut, Nunes-Filipe Carlos, Ohlmeier Martin D, Oswald Pierre, Pallanti Stefano, Pehlivanidis Artemios, Ramos-Quiroga Josep A, Rastam Maria, Ryffel-Rawak Doris, Stes Steven, and Asherson Philip

Subjects
Psychiatry, RC435-571
Abstract

Abstract Background Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. Methods The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. Results Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? Conclusions ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

Published
2010
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147. Adult attention deficit hyperactivity disorder in patients with fibromyalgia syndrome: Assessment and disabilities.

Author

Pallanti, Stefano, Porta, Francesco, and Salerno, Luana

Subjects
*ATTENTION-deficit hyperactivity disorder, *FIBROMYALGIA, *SUBSTANCE abuse, *MENTAL illness, *ANTI-NMDA receptor encephalitis
Abstract

In the broader list of cognitive concerns, neuropsychological testing has shown that attentional impairment may have a specific burden in Fibromyalgia Syndrome (FMS). Preliminary observations have reported a subset of FMS patient screened for attention disorders fulfilling the actual diagnosis of ADHD, a neurodevelopmental disorder characterized by developmentally inadequate levels of inattention, hyperactivity and impulsivity that might persist in adulthood. Yet, no study to date has systematically examined the history and the specific contribution of ADHD to FMS in terms of clinical impact and related specific disabilities. In this study, 106 individuals with a FMS diagnosis based on the 2010 criteria of the American College of Rheumatology have been assessed for (a) the presence of ADHD; (b) the burden of disability caused by ADHD versus FMS; (c) the presence of other psychiatric disorders. Results indicated that ADHD was present in 24.5% of FMS individuals, it was associated with higher FMS symptoms severity and a greater functional impairment, particularly in the work/school domain. Moreover, patients with both FMS and ADHD had higher frequency of substance use disorders than those with FMS only (38.5% versus 3.8%) and mainly opioids. Overall, results suggest that ADHD can increase burden adding specific disability in work and social activities, and it is associated with a trend for the excessive use of opioid painkillers. Detection of neurodevelopmental and actual symptoms of ADHD is highly recommended especially in patient prone to increase the dose of anti-pain medication. • 24.5% of individuals with FMS also have ADHD. • Impairment due to ADHD brings increased total functional and even specific disability. • ADHD is associated with increased use of opiate and sedative drugs. [ABSTRACT FROM AUTHOR]

Published
2021
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149. Strategies for treatment-resistant OCD

Author

Pallanti, Stefano

Subjects
United States. Food and Drug Administration -- Analysis, Obsessive-compulsive disorder -- Care and treatment -- Analysis, Serotonin uptake inhibitors -- Analysis, Health, Psychology and mental health
Abstract

Obsessive-compulsive disorder (OCD) is characterized by the presence of disabling obsessions and/or compulsions, with a lifetime prevalence of 1% to 3% in the general population. (1) It is associated with [...]

Published
2014

150. Manifesto for a European research network into Problematic Usage of the Internet

Author

Fineberg, Naomi A., Demetrovics, Zsolt, Stein, Dan J., Loannidis, Konstantinos, Potenza, Marc N., Grünblatt, Edna, Brand, Matthias, Billieux, Joël, Carmi, Lior, King, Daniel Luke, Grant, Jon E., Yücel, Murat, Dell'Osso, Bernardo, Rumpf, Hans-Jürgen, Hall, Natalie, Hollander, Eric, Goudriaan, Anna, Menchon, Jose M, Zohar, Joseph, Burkauskas, Julius, Martinotti, Giovanni, Van Ameringen, Michael, Corazza, Ornella, Pallanti, Stefano, COST ACTION NETWORK, Chamberlain, Samuel Robin, Fineberg, Naomi A., Demetrovics, Zsolt, Stein, Dan J., Loannidis, Konstantinos, Potenza, Marc N., Grünblatt, Edna, Brand, Matthias, Billieux, Joël, Carmi, Lior, King, Daniel Luke, Grant, Jon E., Yücel, Murat, Dell'Osso, Bernardo, Rumpf, Hans-Jürgen, Hall, Natalie, Hollander, Eric, Goudriaan, Anna, Menchon, Jose M, Zohar, Joseph, Burkauskas, Julius, Martinotti, Giovanni, Van Ameringen, Michael, Corazza, Ornella, Pallanti, Stefano, COST ACTION NETWORK, and Chamberlain, Samuel Robin

Abstract

The Internet is now all-pervasive across much of the globe. While it has positive uses (e.g. prompt access to information, rapid news dissemination), many individuals develop Problematic Use of the Internet (PUI), an umbrella term incorporating a range of repetitive impairing behaviours. The Internet can act as a conduit for, and may contribute to, functionally impairing behaviours including excessive and compulsive video gaming, compulsive sexual behaviour, buying, gambling, streaming or social networks use. There is growing public and National health authority concern about the health and societal costs of PUI across the lifespan. Gaming Disorder is being considered for inclusion as a mental disorder in diagnostic classification systems, and was listed in the ICD-11 version released for consideration by Member States ( http://www.who.int/classifications/icd/revision/timeline/en/ ). More research is needed into disorder definitions, validation of clinical tools, prevalence, clinical parameters, brain-based biology, socio-health-economic impact, and empirically validated intervention and policy ap- proaches. Potential cultural differences in the magnitudes and natures of types and patterns of PUI need to be better understood, to inform optimal health policy and service development. To this end, the EU under Horizon 2020 has launched a new four-year European Cooperation in Science and Technology (COST) Action Programme (CA 16207), bringing together scientists and clinicians from across the fields of impulsive, compulsive, and addictive disorders, to advance networked interdisciplinary research into PUI across Europe and beyond, ultimately seeking to inform regulatory policies and clinical practice. This paper describes nine critical and achievable research priorities identified by the Network, needed in order to advance understanding of PUI, with a view towards identifying vulnerable individuals for early intervention. The network shall enable collaborative research

Published
2018

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