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124. Biocompatible, stimuli-responsive hydrogel of chemically crosslinked β-cyclodextrin as amoxicillin carrier.

Author

Roy, Arpita, Maity, Priti Prasanna, Dhara, Santanu, and Pal, Sagar

Subjects
HYDROGELS, CYCLODEXTRINS, AMOXICILLIN, BIOCOMPATIBILITY, CROSSLINKING (Polymerization), NUCLEAR magnetic resonance spectroscopy, SWELLING of materials
Abstract

ABSTRACT A novel pH-responsive, chemically crosslinked hydrogelator (cl-β-CD/pVP) has been fabricated using β-cyclodextrin (β-CD) and N-vinyl pyrollidone ( N-VP) in presence of diurethane dimethacrylate (DUDMA) crosslinker/azobisisobutyronitrile initiator through free radical polymerization. Various grades of cl-β-CD/pVP have been synthesized and the best grade has been considered with higher crosslinking density, higher gel strength, and lower % swelling ratio. The hydrogelator has been characterized by FTIR, 1H and 13C NMR spectroscopy, TGA, and FESEM analyses. The hydrogelator demonstrates pH-responsive behavior, which has been confirmed by swelling behavior and gel characteristics at various pH (at 37 °C). Using hen egg lysozyme, degradation experiment has been performed, which confirms the biodegradable nature of the hydrogel. The in vitro cytotoxicity study and live-dead assay suggest that the hydrogelator is cytocompatible toward MG-63 cells. Finally, the hydrogelator shows excellent efficacy as an antibiotic (amoxicillin) carrier. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45939. [ABSTRACT FROM AUTHOR]

Published
2018
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144. Single-pot biofabrication of living fibers for tissue engineering applications

Author

Ghosh, Paulomi, Rameshbabu, Arun Prabhu, Das, Dipankar, Subramanian, Bhuvaneshwaran, Samanta, Sintu Kumar, Roy, Sabyasachi, Pal, Sagar, Ghosh, Sudip Kumar, and Dhara, Santanu

Abstract

In this work, morphology, viability, and metabolism of the amniotic mesenchymal stem cells conditioned with different citric acid (CA)/media ratios were investigated using rhodamine-phalloidin/4′,6-diamidino-2-phenylindole staining, live/dead assay, proliferating cell nuclear antigen, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL assay). The cells cultured in 25:75 CA/media displayed well spread actin filaments with a prominent nucleus and evidenced optimum viability. The gelation kinetics of chitosan solution in CA/media (25:75) was monitored via dynamic time sweep analysis on a rheometer. The chemical cross-linking of chitosan with CA was confirmed by nuclear magnetic resonance studies. Subsequently, chitosan solution was extruded in CA/media bath containing cells under benign conditions to form cell-laden fibers (living fibers). The prelabeled cells imaged immediately after fiber formation confirmed the attachment of the cells on the fibers. This approach has several advantages including instantaneous gelation, tunable mechanical properties, and adjustable biodegradability that can provide a platform technology for creating viable three dimensional (3D) building blocks for tissue engineering applications.

Published
2018
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149. SBA-16: Application for the removal of neutral, cationic, and anionic dyes from aqueous medium.

Author

Chaudhuri, Haribandhu, Dash, Subhajit, Ghorai, Soumitra, Pal, Sagar, and Sarkar, Ashis

Subjects
DYES & dyeing, ADSORPTION (Chemistry), SORBENTS
Abstract

The adsorption of four dyes, namely Neutral Red (Basic Red 5, NR), Congo Red (Sodium salt of 3,3′-([1,1′-biphenyl]-4,4′-diyl)bis(4-aminonaphthalene-1-sulfonic acid, CR)), Safranin O (Basic Red 2, SF), and Reactive Red 2 (Red MX-5B, RR2) onto SBA-16 material was studied in detail to investigate the plausible effect of interactions between the adsorbate and adsorbent molecule vis-a-vis determining the pore structure stability of SBA-16 and its potential application for the removal of these dyes from aqueous media. Various characterization techniques including FTIR spectra, Nitrogen adsorption–desorption isotherms, HR-XRD patterns, FE-SEM and HR-TEM analyses of the adsorbent were carried out to get an insight of pre and post adsorption in surface morphology. It was observed that the dye adsorption did not introduce any serious disorder on the pore structure stability of SBA-16 and this material probably be a very promising adsorbent for the removal of both NR and SF ( q m = 276.24 mg g −1 for NR, q m = 240.39 mg g −1 for SF) from aqueous medium. Various adsorption parameters such as pH, contact time, temperature, dye concentration and adsorbent dosage was studied to provide more information about the adsorption characteristics of SBA-16. Kinetics of adsorption followed pseudo-second-order model as well as intraparticle diffusion model. The adsorption isotherms data was well fitted with the Langmuir isotherm model. Thermodynamic parameters suggest that the dye adsorption process is spontaneous. Finally, desorption experiment indicates very good regeneration efficiency of the adsorbent. [ABSTRACT FROM AUTHOR]

Published
2016
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