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Cystic fibrosis (CF), the most common genetically inherited disease in Caucasian populations, is a multi-systemic life-threatening autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (

This study aims to analyze how the Technology Acceptance Model which consists of Percieved usefulness, Perceived Ease of use, Privacy and Security, and additional variable "Promotion Programs" affect behavior intention in using e-wallets or digital wallets in the current pandemic era. A total of 394 respondents aged 16-30 years old who use e-wallets in Yogyakarta were sampled in this study. The results using the SEM test show that perceived usefulness and behavioral intention have a significant effect. Meanwhile, Perceived Ease of use, Privacy and Security, and promotional programs are not significant on E-Wallets Usage.

Asthma is a very heterogeneous disease and since early childhood many classifications have been proposed according to phenotype and endotype. The phenotype includes the clinical features of asthma such as age of onset, triggers, comorbidities, response to treatment and evolution over time. The endotype is more difficult to define, includes the underlying immunopathological mechanisms of the disease and requires reliable biomarkers. A deep knowledge of phenotype and endotype of the patient may guide a tailored therapeutic approach. In this review the main phenotypes and endotypes of asthma acknowledged in children will be discussed.

This study aims to determine the physical properties of Kikim River water in Kikim Timur Subdistrict, Lahat Regency and find out the right way to solve water problems as an effort to treat water from physical parameters that exceed the quality standards according to the Regulation of the Minister of Health of the Republic of Indonesia Number 492 / MENKES / PER / IV / 2018 concerning requirements for drinking water quality. The parameters tested in this study included temperature, total suspended solid (TSS) and degree of acidity (pH). Sampling was carried out at three points, namely Point 01 in Gunung Kembang Village or Kikim Hulu River, Point 02 in Bungamas Village or Kikim Tengah River, and Point 03 in Lubuk Tampang Village or Kikim Hilir River. The results of the test analysis of the Kikim Timur River water samples carried out at the Environmental Service Unit of the Environmental Service Laboratory (DLH) of Lahat Regency at points 01, 02 and 03 indicate that the parameters tested, namely temperature, (TSS) and pH values still meet the standards according to Regulation of the Minister of Health of the Republic of Indonesia Number 492 / MENKES / PER / IV / 2018.

Payment with a non-cash system can simplify transactions and are increasingly used. The advantages of non-cash payments are not only due to convenience, speed up transaction time, and time savings but also the benefits that can reduce the circulation of money in the community. The less the amount of physical money in circulation, it will indirectly affect the inflation rate. However, there are inconsistency of research results regarding the relationship of non-cash transactions and inflation. These issues constitute a research gap on cashless payments and inflation in Indonesia. This study aims to prove the relationship between cashless payments and inflation in Indonesia. Using data from Central Bureau of Statistics Republic of Indonesia and Bank Indonesia over the period 2019-2020Q2, the results confirm that electronic money decrease inflation. The research approach in this study focuses on quantitative analysis using the Ordinary Least Square (OLS) method. The results of this study indicate that partially the relationship between debit card transactions and inflation has no significant effect. Credit card transactions have no significant effect on inflation, while electronic money transactions have a significant effect on inflation in Indonesia. Non-cash transactions intensified by Bank Indonesia through the cash-less society need to be considered more with the public's understanding of the use of non-cash transaction instruments so that the use of non-cash transactions in Indonesia is not only used for cash withdrawals but is used in every transaction.

The clinical relevance of Aspergillus fumigatus (Af) in cystic fibrosis (CF) is controversial. The aims of the study were to assess the prevalence of Af disease in our cohort of CF patients and evaluate whether allergic bronchopulmonary aspergillosis (ABPA) and sensitization to Af affected lung function, body mass index (BMI) and exacerbations.Clinical data and lung function of CF patients aged 6-18 years followed at the CF Centre of Parma (Italy) were recorded. Patients were classified as: patients with no signs of Af, patients sensitized or colonized by Af, patients with ABPA or patients with Aspergillus bronchitis (Ab).Of 38 CF patients (14.2 years (6.2-18.8) M 23), 8 (21%) showed Af sensitization, 7 (18.4%) showed ABPA, 1 (2.6%) showed Af colonization and 1 (2.6%) showed Ab. Compared to non-ABPA, patients with ABPA had lower BMI (15.9 ± 1.6 vs. 19.7 ± 3.4,This study showed the relevant clinical impact of ABPA and Af sensitization in terms of exacerbations and lung structural damage.

Aging is one of the hallmarks of multiple human diseases, including cancer. We hypothesized that variations in the number of copies (CNVs) of specific genes may protect some long-living organisms theoretically more susceptible to tumorigenesis from the onset of cancer. Based on the statistical comparison of gene copy numbers within the genomes of both cancer-prone and -resistant species, we identified novel gene targets linked to tumor predisposition, such as CD52, SAT1 and SUMO. Moreover, considering their genome-wide copy number landscape, we discovered that microRNAs (miRNAs) are among the most significant gene families enriched for cancer progression and predisposition. Through bioinformatics analyses, we identified several alterations in miRNAs copy number patterns, involving miR-221, miR-222, miR-21, miR-372, miR-30b, miR-30d and miR-31, among others. Therefore, our analyses provide the first evidence that an altered miRNAs copy number signature can statistically discriminate species more susceptible to cancer from those that are tumor resistant, paving the way for further investigations.

The main risk factor for chronic obstructive pulmonary disease (COPD) is active smoking. However, a considerable amount of people with COPD never smoked, and increasing evidence suggests that adult lung disease can have its origins in prenatal and early life. This article reviews some of the factors that can potentially affect lung development and lung function trajectories throughout the lifespan from genetics and prematurity to respiratory tract infections and childhood asthma. Maternal smoking and air pollution exposure were also analyzed among the environmental factors. The adoption of preventive strategies to avoid these risk factors since the prenatal period may be crucial to prevent, delay the onset or modify the progression of COPD lung disease throughout life.

Background: Alpha 1 antitrypsin deficiency (AATD) is an autosomal codominant genetic condition that affects Caucasians of the European population due to the presence of a deficient allele of the SERPINA1 gene. A frequency of about 1/5,000 individuals has been estimated in Italy. Objectives: The aim of the study was to evaluate the distribution of the clinical manifestations of severe and intermediate genetic AATD in the geographic area around Parma in Northern Italy. Method: 238 subjects were submitted to molecular analysis of the SERPINA1 gene, and data on anthropometric variables, smoking habits, number of packs per year, AAT serum concentration, and clinical manifestations were recorded and presented as mean ± SD or median values (1st quartile; 3rd quartile). Results: The results show a distribution of genetic AATD of 4.1% of the screened population in the area encompassing the city of Parma. PI*MS and PI*MZ were the most common genotypes at 40.9% and 28.2% of the population with genetic AATD, and asthma and emphysema were the most represented clinical manifestations. Conclusion: Our study allowed to increase the knowledge of the distribution of genetic AATD in Northern Italy providing information regarding frequencies of genotypes and clinical manifestations of the disorder.

Purpose To describe the clinical course of COVID-19 in patients with cystic fibrosis (CF) and to identify risk factors for severe COVID-19. Methods We conducted a prospective study within the Italian CF Society. CF centers collected baseline and follow-up data of patients with virologically confirmed SARS-CoV-2 infection between March 2020 and June 2021. Odds ratios (ORs) for severe SARS-CoV-2 (as defined by hospital admission) were estimated by logistic regression models. Results The study included 236 patients with positive molecular test for SARS-CoV-2. Six patients died, 43 patients were admitted to hospital, 4 admitted to intensive care unit. Pancreatic insufficiency was associated with increased risk of severe COVID-19 (OR 4.04, 95% CI 1.52; 10.8). After adjusting for age and pancreatic insufficiency, forced expiratory volume in one second (FEVp)

Aging is one of the hallmarks of multiple human diseases, including cancer. However, the molecular mechanisms associated with high longevity and low cancer incidence percentages characterizing long-living organisms have not been fully understood yet. In this context, we hypothesized that variations in the number of copies (CNVs) of specific genes may protect some species from cancer onset. Based on the statistical comparison of gene copy numbers within the genomes of cancer -prone and -resistant organisms, we identified novel gene targets linked to the tumor predisposition of a species, such as CD52, SAT1 and SUMO protein family members. Furthermore, for the first time, we were able to discover that, considering the entire genome copy number landscape of a species, microRNAs (miRNAs) are among the most significant gene families enriched for cancer progression and predisposition. However, their roles in ageing and cancer resistance from a comparative perspective remains largely unknown. To this end, we identified through bioinformatics analysis, several alterations in miRNAs copy number patterns, represented by duplication of miR-221, miR-222, miR-21, miR-372, miR-30b, miR-30d and miR-31 among others. Therefore, our analysis provides the first evidence that an altered copy number miRNAs signature is able to statistically discriminate species more susceptible to cancer than those that are tumor resistant, helping researchers to discover new possible therapeutic targets involved in tumor predisposition.