4,476 results on '"P. Chandrasekhar"'
Search Results
102. PolyTO: Structural Topology Optimization using Convex Polygons
- Author
-
Chandrasekhar, Aaditya
- Subjects
Mathematics - Optimization and Control ,Computer Science - Computational Engineering, Finance, and Science - Abstract
In this paper, we propose a topology optimization (TO) framework where the design is parameterized by a set of convex polygons. Extending feature mapping methods in TO, the representation allows for direct extraction of the geometry. In addition, the method allows one to impose geometric constraints such as feature size control directly on the polygons that are otherwise difficult to impose in density or level set based approaches. The use of polygons provides for more more varied shapes than simpler primitives like bars, plates, or circles. The polygons are defined as the feasible set of a collection of halfspaces. Varying the halfspace's parameters allows for us to obtain diverse configurations of the polygons. Furthermore, the halfspaces are differentiably mapped onto a background mesh to allow for analysis and gradient driven optimization. The proposed framework is illustrated through numerous examples of 2D structural compliance minimization TO. Some of the key limitations and future research are also summarized.
- Published
- 2023
103. Comparing 1-year GUMICS-4 simulations of the Terrestrial Magnetosphere with Cluster Measurements
- Author
-
Facsko, Gabor, Sibeck, David, Honkonen, Ilja, Bor, Jozsef, Perez, German Farinas, Timar, Aniko, Shprits, Yuri, Peitso, Pyry, Degener, Laura, Tanskanen, Eija, Anekallu, Chandrasekhar Reddy, Szalai, Sandor, Kis, Arpad, Wesztergom, Viktor, Madar, Akos, Biro, Nikolett, Koban, Gergely, Illyes, Andras, Kovacs, Peter, Dalya, Zsuzsanna, and Lkhagvadorj, Munkhjargal
- Subjects
Physics - Space Physics - Abstract
We compare the predictions of the GUMICS$-$4 global magnetohydrodynamic model for the interaction of the solar wind with the Earth's magnetosphere with Cluster~SC3 measurements for over one year, from January 29, 2002, to February 2, 2003. In particular, we compare model predictions with the north/south component of the magnetic field ($B_{z}$) seen by the magnetometer, the component of the velocity along the Sun-Earth line ($V_{x}$), and the plasma density as determined from a top hat plasma spectrometer and the spacecraft's potential from the electric field instrument. We select intervals in the solar wind, the magnetosheath, and the magnetosphere where these instruments provided good-quality data, and the model correctly predicted the region in which the spacecraft is located. We determine the location of the bow shock, the magnetopause, and the neutral sheet from the spacecraft measurements and compare these locations to those predicted by the simulation. The GUMICS$-$4 model agrees well with the measurements in the solar wind however its accuracy is worse in the magnetosheath. The simulation results are not realistic in the magnetosphere. The bow shock location is predicted well, however, the magnetopause location is less accurate. The neutral sheet positions are located quite accurately thanks to the special solar wind conditions when the $B_{y}$ component of the interplanetary magnetic field is small., Comment: submitted to the AGU Space Weather, 51 pages, 19 figures, 8 tables
- Published
- 2023
- Full Text
- View/download PDF
104. Topology of critical points in boundary matrix duals
- Author
-
Yerra, Pavan Kumar, Bhamidipati, Chandrasekhar, and Mukherji, Sudipta
- Subjects
High Energy Physics - Theory - Abstract
Computation of topological charges of the Schwarzschild and charged black holes in AdS in canonical and grand canonical ensembles allows for a classification of the phase transition points via the Bragg-Williams off-shell free energy. We attempt a topological classification of the critical points and the equilibrium phases of the dual gauge theory via a phenomenological matrix model, which captures the features of the ${\cal{N}}=4$, $SU(N)$ Super Yang-Mills theory on $S^3$ at finite temperature at large $N$. With minimal modification of parameters, critical points of the matrix model at finite chemical potential can be classified as well. The topological charges of locally stable and unstable dynamical phases of the system turn out to be opposite to each other, totalling to zero, and this matches the analysis in the bulk., Comment: v1: 23 pages, 17 figures; v2: 27 pages, 18 figures, 2 Appendices, version to appear in JHEP
- Published
- 2023
105. The Semantic Reader Project: Augmenting Scholarly Documents through AI-Powered Interactive Reading Interfaces
- Author
-
Lo, Kyle, Chang, Joseph Chee, Head, Andrew, Bragg, Jonathan, Zhang, Amy X., Trier, Cassidy, Anastasiades, Chloe, August, Tal, Authur, Russell, Bragg, Danielle, Bransom, Erin, Cachola, Isabel, Candra, Stefan, Chandrasekhar, Yoganand, Chen, Yen-Sung, Cheng, Evie Yu-Yen, Chou, Yvonne, Downey, Doug, Evans, Rob, Fok, Raymond, Hu, Fangzhou, Huff, Regan, Kang, Dongyeop, Kim, Tae Soo, Kinney, Rodney, Kittur, Aniket, Kang, Hyeonsu, Klevak, Egor, Kuehl, Bailey, Langan, Michael, Latzke, Matt, Lochner, Jaron, MacMillan, Kelsey, Marsh, Eric, Murray, Tyler, Naik, Aakanksha, Nguyen, Ngoc-Uyen, Palani, Srishti, Park, Soya, Paulic, Caroline, Rachatasumrit, Napol, Rao, Smita, Sayre, Paul, Shen, Zejiang, Siangliulue, Pao, Soldaini, Luca, Tran, Huy, van Zuylen, Madeleine, Wang, Lucy Lu, Wilhelm, Christopher, Wu, Caroline, Yang, Jiangjiang, Zamarron, Angele, Hearst, Marti A., and Weld, Daniel S.
- Subjects
Computer Science - Human-Computer Interaction ,Computer Science - Artificial Intelligence ,Computer Science - Computation and Language - Abstract
Scholarly publications are key to the transfer of knowledge from scholars to others. However, research papers are information-dense, and as the volume of the scientific literature grows, the need for new technology to support the reading process grows. In contrast to the process of finding papers, which has been transformed by Internet technology, the experience of reading research papers has changed little in decades. The PDF format for sharing research papers is widely used due to its portability, but it has significant downsides including: static content, poor accessibility for low-vision readers, and difficulty reading on mobile devices. This paper explores the question "Can recent advances in AI and HCI power intelligent, interactive, and accessible reading interfaces -- even for legacy PDFs?" We describe the Semantic Reader Project, a collaborative effort across multiple institutions to explore automatic creation of dynamic reading interfaces for research papers. Through this project, we've developed ten research prototype interfaces and conducted usability studies with more than 300 participants and real-world users showing improved reading experiences for scholars. We've also released a production reading interface for research papers that will incorporate the best features as they mature. We structure this paper around challenges scholars and the public face when reading research papers -- Discovery, Efficiency, Comprehension, Synthesis, and Accessibility -- and present an overview of our progress and remaining open challenges.
- Published
- 2023
106. Optical Conductivity Signatures of Floquet Electronic Phases
- Author
-
Cupo, Andrew, Heath, Joshuah T., Cobanera, Emilio, Whitfield, James D., Ramanathan, Chandrasekhar, and Viola, Lorenza
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Other Condensed Matter ,Quantum Physics - Abstract
Optical conductivity measurements may provide access to distinct signatures of Floquet electronic phases, which are described theoretically by their quasienergy band structures. We characterize experimental observables of the Floquet graphene antidot lattice (FGAL), which we introduced previously [Phys. Rev. B 104, 174304 (2021)]. On the basis of Floquet linear response theory, the real and imaginary parts of the longitudinal and Hall optical conductivity are computed as a function of probe frequency. We find that the number and positions of peaks in the response function are distinctive of the different Floquet electronic phases, and identify multiple properties with no equilibrium analog. First, for several intervals of probe frequencies, the real part of the conductivity becomes negative. We argue this is indicative of a subversion of the usual Joule heating mechanism: The Floquet drive causes the material to amplify the power of the probe, resulting in gain. Additionally, while the Hall response vanishes at equilibrium, the real and imaginary parts of the Floquet Hall conductivity are non-zero and can be as large as the longitudinal components. Lastly, driving-induced localization tends to reduce the overall magnitude of and to flatten out the optical conductivity signal. From an implementation standpoint, a major advantage of the FGAL is that the above-bandwidth driving limit is reached with photon energies that are at least twenty times lower than that required for the intrinsic material, allowing for significant band renormalization at orders-of-magnitude smaller intensities. Our work provides the necessary tools for experimentalists to map reflectance data to particular Floquet phases for this novel material.
- Published
- 2023
- Full Text
- View/download PDF
107. Soil Quality and Enhanced Productivity through Soil Organic Matter
- Author
-
P. Chandrasekhar Rao and G. Padmaja
- Subjects
Soil quality, productivity, organic matter, soil health ,Agriculture ,Plant ecology ,QK900-989 - Abstract
Soil quality and health of the soil is a very important factors for growing of crops. The accelerated decomposition of soil organic carbon due to agriculture, resulting in loss of carbon to atmosphere and its contribution to greenhouse effect is a serious problem. Important factors controlling soil SOM status include climate, especially rainfall and temperature hydrology, parent material, soil fertility, biological activity, vegetation and land use. Assessment of soil quality, which is ‘the capacity of the soil to produce safe and nutritious food, to enhance human and animal health and overcome degradative processes” is thought to be a means to maintain soil health and quality. There is no doubt that agricultural management practices such as crop rotations, inclusion of legumes in cropping systems, addition of animal based manures, adoption of soil water conservation practices, various permutations and combinations of deep and shallow tillage, mulching of soils with insitu grown and external plant and leaf materials were part and parcel of agriculture in India. Despite all these efforts, the concept of conservation farming could not be followed in an integrated manner to except greater impact in terms of protecting the soil resource from degradative processes. One of the approaches could be better land husbandry (BLH). It is an integrated and synergistic resource management. Components of BLH are Build up SOM and related biological activity, Integrated plant nutrition management, Better crop management, Better rainwater management, improved soil structure for better rooting depth and permeability, adoption of people centred learning approach and community based participatory approaches.
- Published
- 2016
108. Contact and metric structures in black hole chemistry
- Author
-
Ghosh, Aritra and Bhamidipati, Chandrasekhar
- Subjects
General Relativity and Quantum Cosmology ,Condensed Matter - Statistical Mechanics - Abstract
We review recent studies of contact and thermodynamic geometry for black holes in AdS spacetimes in the extended thermodynamics framework. The cosmological constant gives rise to the notion of pressure $P = -\Lambda / 8 \pi$ and, subsequently a conjugate volume $V$, thereby leading to a close analogy with hydrostatic thermodynamic systems. To begin with, we review the contact geometry approach to thermodynamics in general and then consider thermodynamic metrics constructed as the Hessians of various thermodynamic potentials. We then study their correspondence to statistical ensembles for systems with two-dimensional spaces of equilibrium states. From the zeroes and divergences of the curvature scalar obtained from the metric, we carefully analyze the issue of ensemble non-equivalence and show certain complimentary behaviors in the description of a thermodynamic system. Following a thorough analysis of the familiar van der Waals system, we turn our attention to black holes in extended phase space. Considering the example of charged AdS black holes, we discuss the generic features of their thermodynamic geometry in detail. The relationship of the thermodynamic curvature(s) with critical points as well as microscopic interactions in black holes is also briefly explored. We finally set up the thermodynamic geometry for finite temperature gauge theories dual to black holes in AdS via holographic correspondence and comment on recent progress., Comment: Comments are welcome
- Published
- 2023
109. The Semantic Scholar Open Data Platform
- Author
-
Kinney, Rodney, Anastasiades, Chloe, Authur, Russell, Beltagy, Iz, Bragg, Jonathan, Buraczynski, Alexandra, Cachola, Isabel, Candra, Stefan, Chandrasekhar, Yoganand, Cohan, Arman, Crawford, Miles, Downey, Doug, Dunkelberger, Jason, Etzioni, Oren, Evans, Rob, Feldman, Sergey, Gorney, Joseph, Graham, David, Hu, Fangzhou, Huff, Regan, King, Daniel, Kohlmeier, Sebastian, Kuehl, Bailey, Langan, Michael, Lin, Daniel, Liu, Haokun, Lo, Kyle, Lochner, Jaron, MacMillan, Kelsey, Murray, Tyler, Newell, Chris, Rao, Smita, Rohatgi, Shaurya, Sayre, Paul, Shen, Zejiang, Singh, Amanpreet, Soldaini, Luca, Subramanian, Shivashankar, Tanaka, Amber, Wade, Alex D., Wagner, Linda, Wang, Lucy Lu, Wilhelm, Chris, Wu, Caroline, Yang, Jiangjiang, Zamarron, Angele, Van Zuylen, Madeleine, and Weld, Daniel S.
- Subjects
Computer Science - Digital Libraries ,Computer Science - Computation and Language - Abstract
The volume of scientific output is creating an urgent need for automated tools to help scientists keep up with developments in their field. Semantic Scholar (S2) is an open data platform and website aimed at accelerating science by helping scholars discover and understand scientific literature. We combine public and proprietary data sources using state-of-the-art techniques for scholarly PDF content extraction and automatic knowledge graph construction to build the Semantic Scholar Academic Graph, the largest open scientific literature graph to-date, with 200M+ papers, 80M+ authors, 550M+ paper-authorship edges, and 2.4B+ citation edges. The graph includes advanced semantic features such as structurally parsed text, natural language summaries, and vector embeddings. In this paper, we describe the components of the S2 data processing pipeline and the associated APIs offered by the platform. We will update this living document to reflect changes as we add new data offerings and improve existing services., Comment: 8 pages, 6 figures
- Published
- 2023
110. Machine learning assisted determination of electronic correlations from magnetic resonance
- Author
-
Rao, Anantha, Carr, Stephen, Snider, Charles, Feldman, D. E., Ramanathan, Chandrasekhar, and Mitrović, V. F.
- Subjects
Condensed Matter - Disordered Systems and Neural Networks - Abstract
In the presence of strong electronic spin correlations, the hyperfine interaction imparts long-range coupling between nuclear spins. Efficient protocols for the extraction of such complex information about electron correlations via magnetic response are not well known. Here, we study how machine learning can extract material parameters and help interpret magnetic response experiments. A low-dimensional representation that classifies the total interaction strength is discovered by unsupervised learning. Supervised learning generates models that predict the spatial extent of electronic correlations and the total interaction strength. Our work demonstrates the utility of artificial intelligence in the development of new probes of quantum systems, with applications to experimental studies of strongly correlated materials., Comment: 14 pages, 12 figures
- Published
- 2022
111. Studies on photoluminescence, electrochemical sensors, and photocatalysis using Ho3+-doped MgAl2O4 nanophosphors
- Author
-
Manjula, S. N., Chandrasekhar, M., Anil Kumar, M. R., Bhoomika, V., Raghavendra, N., Somashekar, M. N., Ravikumar, C. R., and Nagabhushana, H.
- Published
- 2024
- Full Text
- View/download PDF
112. A new semi-empirical model for correlation of solubility of ligands in supercritical carbon dioxide
- Author
-
Subashree, K., Shruti Krishna, R., Pitchaiah, K. C., Kumar, Rahul, Chandrasekhar, G., Suresh, A., and Sivaraman, N.
- Published
- 2024
- Full Text
- View/download PDF
113. FluTO: Graded multi-scale topology optimization of large contact area fluid-flow devices using neural networks
- Author
-
Padhy, Rahul Kumar, Chandrasekhar, Aaditya, and Suresh, Krishnan
- Published
- 2024
- Full Text
- View/download PDF
114. In vitro generation of epidermal keratinocytes from human CD34-positive hematopoietic stem cells
- Author
-
Sireesha, Kodavala, Samundeshwari, Echambadi Loganathan, Surekha, Kattaru, Chandrasekhar, Chodimella, and Sarma, Potukuchi Venkata Gurunadha Krishna
- Published
- 2024
- Full Text
- View/download PDF
115. Current-Induced Domain Wall NOT Gate Logic Operation via Chirality Flipping by Exploiting Walker Breakdown
- Author
-
Haragopal, Vemuru, Jaiswal, Rohan, Kannan, Vijayanandhini, Murapaka, Chandrasekhar, and Lew, Wen Siang
- Published
- 2024
- Full Text
- View/download PDF
116. Is intraoperative electrocorticography (ECoG) for long-term epilepsy-associated tumors (LEATs) more useful in children?—A Randomized Controlled Trial
- Author
-
Rajeev, Sreenath Prabha, Darshan, H. R., Vilanilam, George Chandy, Abraham, Mathew, Keshavapisharady, Krishnakumar, Venkat, Easwer Hariharan, Stanley, Antony, Menon, Ramshekhar N., Radhakrishnan, Ashalatha, Cherian, Ajith, Narasimaiah, Deepti, Thomas, Bejoy, Kesavadas, Chandrasekhar, and Vimala, Smita
- Published
- 2024
- Full Text
- View/download PDF
117. Performance Evaluation of Metallic Honeycomb and Gyroid Micro-lattice Structures for Armoured Fighting Vehicles
- Author
-
Reddy, B. Veera Siva, Shaik, Ameer Malik, Sundeep, Dola, Chebiyyam, Chandrasekhara Sastry, Krishnaiah, J., and Chandrasekhar, U.
- Published
- 2024
- Full Text
- View/download PDF
118. Marfan Syndrome with type-1 diabetes and pulmonary tuberculosis – A rare case
- Author
-
Hemanth Kumar Kalla and P. Chandrasekhar
- Subjects
Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Published
- 2015
- Full Text
- View/download PDF
119. BLOOM: A 176B-Parameter Open-Access Multilingual Language Model
- Author
-
Workshop, BigScience, Scao, Teven Le, Fan, Angela, Akiki, Christopher, Pavlick, Ellie, Ilić, Suzana, Hesslow, Daniel, Castagné, Roman, Luccioni, Alexandra Sasha, Yvon, François, Gallé, Matthias, Tow, Jonathan, Rush, Alexander M., Biderman, Stella, Webson, Albert, Ammanamanchi, Pawan Sasanka, Wang, Thomas, Sagot, Benoît, Muennighoff, Niklas, del Moral, Albert Villanova, Ruwase, Olatunji, Bawden, Rachel, Bekman, Stas, McMillan-Major, Angelina, Beltagy, Iz, Nguyen, Huu, Saulnier, Lucile, Tan, Samson, Suarez, Pedro Ortiz, Sanh, Victor, Laurençon, Hugo, Jernite, Yacine, Launay, Julien, Mitchell, Margaret, Raffel, Colin, Gokaslan, Aaron, Simhi, Adi, Soroa, Aitor, Aji, Alham Fikri, Alfassy, Amit, Rogers, Anna, Nitzav, Ariel Kreisberg, Xu, Canwen, Mou, Chenghao, Emezue, Chris, Klamm, Christopher, Leong, Colin, van Strien, Daniel, Adelani, David Ifeoluwa, Radev, Dragomir, Ponferrada, Eduardo González, Levkovizh, Efrat, Kim, Ethan, Natan, Eyal Bar, De Toni, Francesco, Dupont, Gérard, Kruszewski, Germán, Pistilli, Giada, Elsahar, Hady, Benyamina, Hamza, Tran, Hieu, Yu, Ian, Abdulmumin, Idris, Johnson, Isaac, Gonzalez-Dios, Itziar, de la Rosa, Javier, Chim, Jenny, Dodge, Jesse, Zhu, Jian, Chang, Jonathan, Frohberg, Jörg, Tobing, Joseph, Bhattacharjee, Joydeep, Almubarak, Khalid, Chen, Kimbo, Lo, Kyle, Von Werra, Leandro, Weber, Leon, Phan, Long, allal, Loubna Ben, Tanguy, Ludovic, Dey, Manan, Muñoz, Manuel Romero, Masoud, Maraim, Grandury, María, Šaško, Mario, Huang, Max, Coavoux, Maximin, Singh, Mayank, Jiang, Mike Tian-Jian, Vu, Minh Chien, Jauhar, Mohammad A., Ghaleb, Mustafa, Subramani, Nishant, Kassner, Nora, Khamis, Nurulaqilla, Nguyen, Olivier, Espejel, Omar, de Gibert, Ona, Villegas, Paulo, Henderson, Peter, Colombo, Pierre, Amuok, Priscilla, Lhoest, Quentin, Harliman, Rheza, Bommasani, Rishi, López, Roberto Luis, Ribeiro, Rui, Osei, Salomey, Pyysalo, Sampo, Nagel, Sebastian, Bose, Shamik, Muhammad, Shamsuddeen Hassan, Sharma, Shanya, Longpre, Shayne, Nikpoor, Somaieh, Silberberg, Stanislav, Pai, Suhas, Zink, Sydney, Torrent, Tiago Timponi, Schick, Timo, Thrush, Tristan, Danchev, Valentin, Nikoulina, Vassilina, Laippala, Veronika, Lepercq, Violette, Prabhu, Vrinda, Alyafeai, Zaid, Talat, Zeerak, Raja, Arun, Heinzerling, Benjamin, Si, Chenglei, Taşar, Davut Emre, Salesky, Elizabeth, Mielke, Sabrina J., Lee, Wilson Y., Sharma, Abheesht, Santilli, Andrea, Chaffin, Antoine, Stiegler, Arnaud, Datta, Debajyoti, Szczechla, Eliza, Chhablani, Gunjan, Wang, Han, Pandey, Harshit, Strobelt, Hendrik, Fries, Jason Alan, Rozen, Jos, Gao, Leo, Sutawika, Lintang, Bari, M Saiful, Al-shaibani, Maged S., Manica, Matteo, Nayak, Nihal, Teehan, Ryan, Albanie, Samuel, Shen, Sheng, Ben-David, Srulik, Bach, Stephen H., Kim, Taewoon, Bers, Tali, Fevry, Thibault, Neeraj, Trishala, Thakker, Urmish, Raunak, Vikas, Tang, Xiangru, Yong, Zheng-Xin, Sun, Zhiqing, Brody, Shaked, Uri, Yallow, Tojarieh, Hadar, Roberts, Adam, Chung, Hyung Won, Tae, Jaesung, Phang, Jason, Press, Ofir, Li, Conglong, Narayanan, Deepak, Bourfoune, Hatim, Casper, Jared, Rasley, Jeff, Ryabinin, Max, Mishra, Mayank, Zhang, Minjia, Shoeybi, Mohammad, Peyrounette, Myriam, Patry, Nicolas, Tazi, Nouamane, Sanseviero, Omar, von Platen, Patrick, Cornette, Pierre, Lavallée, Pierre François, Lacroix, Rémi, Rajbhandari, Samyam, Gandhi, Sanchit, Smith, Shaden, Requena, Stéphane, Patil, Suraj, Dettmers, Tim, Baruwa, Ahmed, Singh, Amanpreet, Cheveleva, Anastasia, Ligozat, Anne-Laure, Subramonian, Arjun, Névéol, Aurélie, Lovering, Charles, Garrette, Dan, Tunuguntla, Deepak, Reiter, Ehud, Taktasheva, Ekaterina, Voloshina, Ekaterina, Bogdanov, Eli, Winata, Genta Indra, Schoelkopf, Hailey, Kalo, Jan-Christoph, Novikova, Jekaterina, Forde, Jessica Zosa, Clive, Jordan, Kasai, Jungo, Kawamura, Ken, Hazan, Liam, Carpuat, Marine, Clinciu, Miruna, Kim, Najoung, Cheng, Newton, Serikov, Oleg, Antverg, Omer, van der Wal, Oskar, Zhang, Rui, Zhang, Ruochen, Gehrmann, Sebastian, Mirkin, Shachar, Pais, Shani, Shavrina, Tatiana, Scialom, Thomas, Yun, Tian, Limisiewicz, Tomasz, Rieser, Verena, Protasov, Vitaly, Mikhailov, Vladislav, Pruksachatkun, Yada, Belinkov, Yonatan, Bamberger, Zachary, Kasner, Zdeněk, Rueda, Alice, Pestana, Amanda, Feizpour, Amir, Khan, Ammar, Faranak, Amy, Santos, Ana, Hevia, Anthony, Unldreaj, Antigona, Aghagol, Arash, Abdollahi, Arezoo, Tammour, Aycha, HajiHosseini, Azadeh, Behroozi, Bahareh, Ajibade, Benjamin, Saxena, Bharat, Ferrandis, Carlos Muñoz, McDuff, Daniel, Contractor, Danish, Lansky, David, David, Davis, Kiela, Douwe, Nguyen, Duong A., Tan, Edward, Baylor, Emi, Ozoani, Ezinwanne, Mirza, Fatima, Ononiwu, Frankline, Rezanejad, Habib, Jones, Hessie, Bhattacharya, Indrani, Solaiman, Irene, Sedenko, Irina, Nejadgholi, Isar, Passmore, Jesse, Seltzer, Josh, Sanz, Julio Bonis, Dutra, Livia, Samagaio, Mairon, Elbadri, Maraim, Mieskes, Margot, Gerchick, Marissa, Akinlolu, Martha, McKenna, Michael, Qiu, Mike, Ghauri, Muhammed, Burynok, Mykola, Abrar, Nafis, Rajani, Nazneen, Elkott, Nour, Fahmy, Nour, Samuel, Olanrewaju, An, Ran, Kromann, Rasmus, Hao, Ryan, Alizadeh, Samira, Shubber, Sarmad, Wang, Silas, Roy, Sourav, Viguier, Sylvain, Le, Thanh, Oyebade, Tobi, Le, Trieu, Yang, Yoyo, Nguyen, Zach, Kashyap, Abhinav Ramesh, Palasciano, Alfredo, Callahan, Alison, Shukla, Anima, Miranda-Escalada, Antonio, Singh, Ayush, Beilharz, Benjamin, Wang, Bo, Brito, Caio, Zhou, Chenxi, Jain, Chirag, Xu, Chuxin, Fourrier, Clémentine, Periñán, Daniel León, Molano, Daniel, Yu, Dian, Manjavacas, Enrique, Barth, Fabio, Fuhrimann, Florian, Altay, Gabriel, Bayrak, Giyaseddin, Burns, Gully, Vrabec, Helena U., Bello, Imane, Dash, Ishani, Kang, Jihyun, Giorgi, John, Golde, Jonas, Posada, Jose David, Sivaraman, Karthik Rangasai, Bulchandani, Lokesh, Liu, Lu, Shinzato, Luisa, de Bykhovetz, Madeleine Hahn, Takeuchi, Maiko, Pàmies, Marc, Castillo, Maria A, Nezhurina, Marianna, Sänger, Mario, Samwald, Matthias, Cullan, Michael, Weinberg, Michael, De Wolf, Michiel, Mihaljcic, Mina, Liu, Minna, Freidank, Moritz, Kang, Myungsun, Seelam, Natasha, Dahlberg, Nathan, Broad, Nicholas Michio, Muellner, Nikolaus, Fung, Pascale, Haller, Patrick, Chandrasekhar, Ramya, Eisenberg, Renata, Martin, Robert, Canalli, Rodrigo, Su, Rosaline, Su, Ruisi, Cahyawijaya, Samuel, Garda, Samuele, Deshmukh, Shlok S, Mishra, Shubhanshu, Kiblawi, Sid, Ott, Simon, Sang-aroonsiri, Sinee, Kumar, Srishti, Schweter, Stefan, Bharati, Sushil, Laud, Tanmay, Gigant, Théo, Kainuma, Tomoya, Kusa, Wojciech, Labrak, Yanis, Bajaj, Yash Shailesh, Venkatraman, Yash, Xu, Yifan, Xu, Yingxin, Xu, Yu, Tan, Zhe, Xie, Zhongli, Ye, Zifan, Bras, Mathilde, Belkada, Younes, and Wolf, Thomas
- Subjects
Computer Science - Computation and Language - Abstract
Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.
- Published
- 2022
120. Nonlocal Differential Resistance in AlO$_x$/KTaO$_3$ Heterostructures
- Author
-
Krantz, Patrick W and Chandrasekhar, Venkat
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Local and nonlocal differential resistance measurements on Hall bars defined in AlO$_x$/KTaO$_3$ heterostructures show anomalous behavior that depends on the crystal orientation and the applied back gate voltage. The local differential resistance is asymmetric in the dc bias current, with an antisymmetric component that grows with decreasing gate voltage. More surprisingly, a large nonlocal differential resistance is observed that extends between measurement probes that are separated by 100s of microns. The potential source of this anomalous behavior is discussed.
- Published
- 2022
121. Spin Squeezing as a Probe of Emergent Quantum Orders
- Author
-
Nikolov, Ilija K., Carr, Stephen, Del Maestro, Adrian G., Ramanathan, Chandrasekhar, and Mitrović, Vesna F.
- Subjects
Quantum Physics ,Condensed Matter - Other Condensed Matter ,Condensed Matter - Strongly Correlated Electrons - Abstract
Nuclear magnetic resonance (NMR) experiments can reveal local properties in materials, but are often limited by the low signal-to-noise ratio. Spin squeezed states have an improved resolution below the Heisenberg limit in one of the spin components, and have been extensively used to improve the sensitivity of atomic clocks, for example. Interacting and entangled spin ensembles with non-linear coupling are a natural candidate for implementing squeezing. Here, we propose measurement of the spin-squeezing parameter that itself can act as a local probe of emergent orders in quantum materials. In particular, we demonstrate how to investigate an anisotropic electric field gradient via its coupling to the nuclear quadrupole moment. While squeezed spin states are pure, the squeezing parameter can be estimated for both pure and mixed states. We evaluate the range of fields and temperatures for which a thermal-equilibrium state is sufficient to improve the resolution in an NMR experiment and probe relevant parameters of the quadrupole Hamiltonian, including its anisotropy.
- Published
- 2022
- Full Text
- View/download PDF
122. Colossal Spontaneous Hall Effect and Emergent Magnetism in KTaO$_3$ Two-Dimensional Electron Gases
- Author
-
Krantz, Patrick, Tyner, Alex, Goswami, Pallab, and Chandrasekhar, Venkat
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Superconductivity - Abstract
There has been intense recent interest in the two-dimensional electron gases (2DEGs) that form at the surfaces and interfaces of KTaO$_3$ (KTO), with the discovery of superconductivity at temperatures significantly higher than those of similar 2DEGs based on SrTiO$_3$ (STO). Here we demonstrate that KTO 2DEGs fabricated under conditions that suppress the superconductivity show a large spontaneous Hall effect at low temperatures. The transverse response is asymmetric in an applied perpendicular magnetic field and becomes hysteretic at millikelvin temperatures. The hysteresis is due to long range magnetic order arising from local Ta$^{4+}$ moments. However, the most striking features of the data are the asymmetry of the transverse response and the large spontaneous transverse resistance at zero field, which can be a significant fraction of the longitudinal resistance and depends on crystal orientation. Both effects are due to the presence of a dominant contribution to the transverse response that is symmetric in perpendicular field, suggesting that its origin is topological in nature. We argue that this contribution arises from Berry curvature dipoles coupled with nonequilibrium conditions induced by the measuring current., Comment: 6 Pages of main text with 6 figures, includes supplementary materials
- Published
- 2022
123. FluTO: Graded Multiscale Fluid Topology Optimization using Neural Networks
- Author
-
Padhy, Rahul Kumar, Chandrasekhar, Aaditya, and Suresh, Krishnan
- Subjects
Mathematics - Numerical Analysis ,Computer Science - Machine Learning - Abstract
Fluid-flow devices with low dissipation, but high contact area, are of importance in many applications. A well-known strategy to design such devices is multi-scale topology optimization (MTO), where optimal microstructures are designed within each cell of a discretized domain. Unfortunately, MTO is computationally very expensive since one must perform homogenization of the evolving microstructures, during each step of the homogenization process. As an alternate, we propose here a graded multiscale topology optimization (GMTO) for designing fluid-flow devices. In the proposed method, several pre-selected but size-parameterized and orientable microstructures are used to fill the domain optimally. GMTO significantly reduces the computation while retaining many of the benefits of MTO. In particular, GMTO is implemented here using a neural-network (NN) since: (1) homogenization can be performed off-line, and used by the NN during optimization, (2) it enables continuous switching between microstructures during optimization, (3) the number of design variables and computational effort is independent of number of microstructure used, and, (4) it supports automatic differentiation, thereby eliminating manual sensitivity analysis. Several numerical results are presented to illustrate the proposed framework.
- Published
- 2022
124. Probing the topological band structure of diffusive multiterminal Josephson junction devices with conductance measurements
- Author
-
Chandrasekhar, Venkat
- Subjects
Condensed Matter - Superconductivity ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The energy of an Andreev bound state in a clean normal metal in contact with two superconductors disperses with the difference $\Delta \phi$ in the superconducting phase between the superconductors in much the same way as the energies of electrons in a one-dimensional crystal disperse with the crystal momentum $k$ of the electrons. A normal metal with $n$ superconductors maps on to a $n-1$ dimensional crystal, each dimension corresponding to the phase difference $\phi_i$ between a specific pair of superconductors. The resulting band structure as a function of the phase differences $\{\Delta \phi_i\}$ has been proposed to have a topological nature, with gapped regions characterized by different Chern numbers separated by regions where the gap in the quasiparticle spectrum closes. A similar complex evolution of the quasiparticle spectrum with $\{\Delta \phi_i\}$ has also been predicted for diffusive normal metals in contact with multiple superconductors. Here we show that the variation of the density of states at the Fermi energy of such a system can be directly probed by relatively simple conductance measurements, allowing rapid characterization of the energy spectrum., Comment: 4 pages, 4 figures
- Published
- 2022
- Full Text
- View/download PDF
125. Stability of Linear Boolean Networks
- Author
-
Chandrasekhar, Karthik, Kadelka, Claus, Laubenbacher, Reinhard, and Murrugarra, David
- Subjects
Nonlinear Sciences - Chaotic Dynamics ,Computer Science - Discrete Mathematics ,Mathematics - Combinatorics ,Quantitative Biology - Molecular Networks - Abstract
Stability is an important characteristic of network models that has implications for other desirable aspects such as controllability. The stability of a Boolean network depends on various factors, such as the topology of its wiring diagram and the type of the functions describing its dynamics. In this paper, we study the stability of linear Boolean networks by computing Derrida curves and quantifying the number of attractors and cycle lengths imposed by their network topologies. Derrida curves are commonly used to measure the stability of Boolean networks and several parameters such as the average in-degree K and the output bias p can indicate if a network is stable, critical, or unstable. For random unbiased Boolean networks there is a critical connectivity value Kc=2 such that if K
Kc networks operate in the chaotic regime. Here, we show that for linear networks, which are the least canalizing and most unstable, the phase transition from order to chaos already happens at an average in-degree of Kc=1. Consistently, we also show that unstable networks exhibit a large number of attractors with very long limit cycles while stable and critical networks exhibit fewer attractors with shorter limit cycles. Additionally, we present theoretical results to quantify important dynamical properties of linear networks. First, we present a formula for the proportion of attractor states in linear systems. Second, we show that the expected number of fixed points in linear systems is 2, while general Boolean networks possess on average one fixed point. Third, we present a formula to quantify the number of bijective linear Boolean networks and provide a lower bound for the percentage of this type of network., Comment: 18 pages, 3 figures - Published
- 2022
- Full Text
- View/download PDF
126. Loss of DNA repair mechanisms in cardiac myocytes induce dilated cardiomyopathy.
- Author
-
Henpita, Chathurika, Vyas, Rajesh, Healy, Chastity, Kieu, Tra, Gurkar, Aditi, Yousefzadeh, Matthew, Cui, Yuxiang, Lu, Aiping, Angelini, Luise, OKelly, Ryan, McGowan, Sara, Chandrasekhar, Sanjay, Vanderpool, Rebecca, Hennessy-Wack, Danielle, Ross, Mark, Bachman, Timothy, McTiernan, Charles, Pillai, Smitha, Ladiges, Warren, Lavasani, Mitra, Huard, Johnny, Beer-Stolz, Donna, St Croix, Claudette, Watkins, Simon, Robbins, Paul, Mora, Ana, Kelley, Eric, Wang, Yinsheng, OConnell, Timothy, and Niedernhofer, Laura
- Subjects
cardiomyopathy ,congestive heart failure ,genotoxic stress ,oxidative stress ,Mice ,Animals ,Myocytes ,Cardiac ,Cardiomyopathy ,Dilated ,Tumor Suppressor Protein p53 ,Myocardium ,DNA Repair - Abstract
Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. Genotoxic cancer therapies are known to be potent drivers of cardiomyopathy, whereas causes of spontaneous disease remain unclear. To test the hypothesis that endogenous genotoxic stress contributes to cardiomyopathy, we deleted the DNA repair gene Ercc1 specifically in striated muscle using a floxed allele of Ercc1 and mice expressing Cre under control of the muscle-specific creatinine kinase (Ckmm) promoter or depleted systemically (Ercc1-/D mice). Ckmm-Cre+/- ;Ercc1-/fl mice expired suddenly of heart disease by 7 months of age. As young adults, the hearts of Ckmm-Cre+/- ;Ercc1-/fl mice were structurally and functionally normal, but by 6-months-of-age, there was significant ventricular dilation, wall thinning, interstitial fibrosis, and systolic dysfunction indicative of dilated cardiomyopathy. Cardiac tissue from the tissue-specific or systemic model showed increased apoptosis and cardiac myocytes from Ckmm-Cre+/- ;Ercc1-/fl mice were hypersensitive to genotoxins, resulting in apoptosis. p53 levels and target gene expression, including several antioxidants, were increased in cardiac tissue from Ckmm-Cre+/- ;Ercc1-/fl and Ercc1-/D mice. Despite this, cardiac tissue from older mutant mice showed evidence of increased oxidative stress. Genetic or pharmacologic inhibition of p53 attenuated apoptosis and improved disease markers. Similarly, overexpression of mitochondrial-targeted catalase improved disease markers. Together, these data support the conclusion that DNA damage produced endogenously can drive cardiac disease and does so mechanistically via chronic activation of p53 and increased oxidative stress, driving cardiac myocyte apoptosis, dilated cardiomyopathy, and sudden death.
- Published
- 2023
127. Baculovirus expression and purification of virion core and envelope proteins of goatpox virus to evaluate their diagnostic potential
- Author
-
Kushwaha, Anand, Kumar, Amit, Chandrasekhar, S., Poulinlu, G., Chand, Karam, Muthuchelvan, D., and Venkatesan, G.
- Published
- 2024
- Full Text
- View/download PDF
128. Fog-Assisted Blockchain-IoMT Healthcare Framework with Role-Based Access Control for Critically Ill Patients
- Author
-
Mallick, Soubhagya Ranjan, Lenka, Rakesh Kumar, Tripathy, Pradyumna Kumar, Rao, D. Chandrasekhar, Sharma, Suraj, and Ray, Niranjan Kumar
- Published
- 2024
- Full Text
- View/download PDF
129. Structural and Optical Studies on Cr-Doped ZnS Nanoparticles Prepared by Flat Co-precipitation Method
- Author
-
ShunmugaSundaram, P., Shanmugam, R., Elangovan, A., Chandrasekhar, L. Bruno, Gurushankar, K., and Arivazhagan, G.
- Published
- 2024
- Full Text
- View/download PDF
130. A comparative analysis of NBT ceramics sintered via conventional and microwave methods
- Author
-
Sahu, Rashmirekha, Chandrasekhar, M., Goyal, Rajat Kumar, and Kumar, Pawan
- Published
- 2024
- Full Text
- View/download PDF
131. TOMAS: topology optimization of multiscale fluid flow devices using variational auto-encoders and super-shapes
- Author
-
Padhy, Rahul Kumar, Suresh, Krishnan, and Chandrasekhar, Aaditya
- Published
- 2024
- Full Text
- View/download PDF
132. Functional Genome Analysis of a Conditionally Pathogenic Rhizobacterial Strain, Pseudomonas putida AKMP7
- Author
-
Gopalan, Raja, Behera, Atish K., Srivastava, Alka, Murugkar, Vrishali, Arigela, Chandrasekhar, Dasgupta, Nandini, Das, Gautam, Grover, Minakshi, and Mohapatra, Sridev
- Published
- 2024
- Full Text
- View/download PDF
133. Cobra (Naja naja) venom L-amino acid oxidase (NNLAAO70) induces apoptosis and secondary necrosis in human lung epithelial cancer cells
- Author
-
Rayapati, Ananda Murali, Vemulapati, Bhadramurthy, and Chanda, Chandrasekhar
- Published
- 2024
- Full Text
- View/download PDF
134. A Review on the Feasibility of AI-Supported Education Platforms in Afghanistan: Addressing Barriers to Women and Girls' Education.
- Author
-
Aziz Ullah Karimy, Juma Rasuli, P. Chandrasekhar Reddy, Musa Joya, Ali Juma Hamdard, and Hassan Rahnaward Ghulami
- Published
- 2024
- Full Text
- View/download PDF
135. Academic and Attendance Outcomes after Participation in a School Breakfast Program
- Author
-
Chandrasekhar, Aparajita, Xie, Luyu, Mathew, Matthew S., Fletcher, Julie G., Craker, Kelsey, Parayil, Megin, and Messiah, Sarah E.
- Abstract
Background: Little is known about how school breakfast programs are associated with school attendance and academic performance. This study evaluated Dallas Independent School District's (DISD) breakfast after the bell (BATB) program that provides breakfast for both habitually tardy and non-tardy students on (1) academic performance and (2) student attendance over 2 school years. Methods: A pre-post study design evaluated the impact of the BATB program in elementary/middle/high schools on student attendance and academic outcomes. Paired t-tests evaluated changes in outcomes between 2017 to 2018 and 2018 to 2019 school years. Results: The analytical sample consisted of 30,493 students (70.32% BATB participants, 50.47% male, 68.78% Hispanic). BATB participants were over 2.5 times more likely to attend school versus non-BATB participants (aOR = 2.55; 95% confidence interval [CI]: 2.23-2.92; p < 0.001). Compared to pre-participation (2017-2018), unadjusted models showed 2018 to 2019 BATB participants' mean reading scores increased from 1502.72 to 1545.76 during the 2018 to 2019 academic year (p < 0.001). There were no significant changes in reading and math scores over the 2-year implementation after adjustment. Conclusions: Results here showed that a school breakfast program that is housed in a large public school system that serves predominantly low resource, ethnically diverse students is associated with increased student attendance.
- Published
- 2023
- Full Text
- View/download PDF
136. Multi-modal spectroscopy of order parameter distributions
- Author
-
Carr, Stephen, Nikolov, Ilija K., Cong, Rong, Del Maestro, Adrian, Ramanathan, Chandrasekhar, and Mitrović, V. F.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We present a multi-modal spectroscopic paradigm that enables independent measurement of charge and spin degrees of freedom (DOF) in strongly correlated materials. This spin-based technique probes symmetry-specific Hamiltonian parameters by analyzing how the time delay between applied pulses ($\tau$) affects the response. We demonstrate ways in which charge DOF that couple through the quadrupolar interaction (inversion symmetric) can be independently measured even in the presence of large magnetic noise (inversion asymmetric). The method quantifies both the strength of the interactions and its distribution (noise). We provide protocols to directly and independently measure the distribution of interaction strengths, even when the average value of the interaction is zero. By independently measuring distributions of different forms of disorder, this methodology can elucidate which microscopic symmetry drives a phase transition. We discuss potential applications to study complex phase transitions in strongly interacting quantum materials., Comment: 14 pages, 6 figures
- Published
- 2022
- Full Text
- View/download PDF
137. Topology of critical points and Hawking-Page transition
- Author
-
Yerra, Pavan Kumar, Bhamidipati, Chandrasekhar, and Mukherji, Sudipta
- Subjects
High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
Using the Bragg-Williams construction of an off-shell free energy we compute the topological charge of the Hawking-Page transition point for black holes in AdS. A computation following from a related off-shell effective potential in the boundary gauge dual matches the value of topological charge obtained in the bulk. We also compute the topological charges of the equilibrium phases of these systems, which follow from the saddle points of the appropriate free energy. The locally stable and unstable phases turn out to have topological charges opposite to each other, with the total being zero, in agreement with the result obtained from a related construction [arXiv:2208.01932]., Comment: 14 pages, 6 figures
- Published
- 2022
- Full Text
- View/download PDF
138. Room Temperature DNP of Diamond Powder Using Frequency Modulation
- Author
-
Shimon, Daphna, Cantwell, Kelly A., Joseph, Linta, and Ramanathan, Chandrasekhar
- Subjects
Physics - Chemical Physics ,Condensed Matter - Materials Science - Abstract
Dynamic nuclear polarization (DNP) is a method of enhancing NMR signals via the transfer of polarization from electron spins to nuclear spins using on-resonance microwave (MW) irradiation. In most cases, monochromatic continuous-wave (MCW) MW irradiation is used. Recently, several groups have shown that the use of frequency modulation of the MW irradiation can result in an additional increase in DNP enhancement above that obtained with MCW. The effect of frequency modulation on the solid effect (SE) and the cross effect (CE) has previously been studied using the stable organic radical 4-hydroxy TEMPO (TEMPOL) at temperatures under 20 K. Here, in addition to the SE and CE, we discuss the effect of frequency modulation on the Overhauser effect (OE) and the truncated CE (tCE) in the room-temperature $^{13}$C-DNP of diamond powders. We recently showed that diamond powders can exhibit multiple DNP mechanisms simultaneously due to the heterogeneity of P1 (substitutional nitrogen) environments within diamond crystallites. We explore the enhancement obtained via the two most important parameters for frequency modulation 1) Modulation frequency, $f_{m}$ (how fast the modulation frequency is varied) and 2) Modulation amplitude, $\Delta\omega$ (the magnitude of the change in microwave frequency) influence the enhancement obtained via each mechanism. Frequency modulation during DNP not only allows us to improve DNP enhancement, but also gives us a way to control which DNP mechanism is most active. By choosing the appropriate modulation parameters, we can selectively enhance some mechanisms while simultaneously suppressing others.
- Published
- 2022
- Full Text
- View/download PDF
139. Characterization of Nb films for superconducting qubits using phase boundary measurements
- Author
-
Ryan, Kevin M., Torres-Castanedo, Carlos G., Goronzy, Dominic P., Wetter, David A. Garcia, Reagor, Matthew J, Field, Mark, Kopas, Cameron J, Marshall, Jayss, Bedzyk, Michael J., Hersam, Mark C., and Chandrasekhar, Venkat
- Subjects
Condensed Matter - Superconductivity - Abstract
Continued advances in superconducting qubit performance require more detailed understandings of the many sources of decoherence. Within these devices, two-level systems arise due to defects, interfaces, and grain boundaries, and are thought to be a major source of qubit decoherence at millikelvin temperatures. In addition to Al, Nb is a commonly used metalization layer for superconducting qubits. Consequently, a significant effort is required to develop and qualify processes that mitigate defects in Nb films. As the fabrication of complete superconducting qubits and their characterization at millikelvin temperatures is a time and resource intensive process, it is desirable to have measurement tools that can rapidly characterize the properties of films and evaluate different treatments. Here we show that measurements of the variation of the superconducting critical temperature $T_c$ with an applied external magnetic field $H$ (of the phase boundary $T_c - H$) performed with very high resolution show features that are directly correlated with the structure of the Nb films. In combination with x-ray diffraction measurements, we show that one can even distinguish variations quality and crystal orientation of the grains in a Nb film by small but reproducible changes in the measured superconducting phase boundary.
- Published
- 2022
- Full Text
- View/download PDF
140. Large Room Temperature Bulk DNP of $^{13}$C via P1 Centers in Diamond
- Author
-
Shimon, Daphna, Cantwell, Kelly A., Joseph, Linta, Williams, Ethan Q., Peng, Zaili, Takahashi, Susumu, and Ramanathan, Chandrasekhar
- Subjects
Condensed Matter - Materials Science ,Physics - Chemical Physics - Abstract
We use microwave-induced dynamic nuclear polarization (DNP) of the substitutional nitrogen defects (P1 centers) in diamond to hyperpolarize bulk $^{13}$C nuclei in both single crystal and powder samples at room temperature at 3.34 T. The large ($>100$-fold) enhancements demonstrated correspond to a greater than 10,000 fold improvement in terms of signal averaging of the 1\% abundant $^{13}$C spins. The DNP was performed using low-power solid state sources under static (non-spinning) conditions. The DNP spectrum (DNP enhancement as a function of microwave frequency) of diamond powder shows features that broadly correlate with the EPR spectrum. A well-defined negative Overhauser peak and two solid effect peaks are observed for the central ($m_I=0$) manifold of the $^{14}$N spins. Previous low temperature measurements in diamond had measured a positive Overhauser enhancement in this manifold. Frequency-chirped millimeter-wave excitation of the electron spins is seen to significantly improve the enhancements for the two outer nuclear spin manifolds ($m_I = \pm 1$) and to blur some of the sharper features associated with the central manifolds. The outer lines are best fit using a combination of the cross effect and a truncated cross effect -- which is known to mimic features of an Overhauser effect. Similar features are also observed in experiments on single crystal samples. The observation of all of these mechanisms in a single material system under the same experimental conditions is likely due to the significant heterogeneity of the high pressure, high temperature (HPHT) type Ib diamond samples used. Large room temperature DNP enhancements at fields above a few Tesla enable spectroscopic studies with better chemical shift resolution under ambient conditions.
- Published
- 2022
- Full Text
- View/download PDF
141. Topology of Born-Infeld AdS black holes in 4D novel Einstein-Gauss-Bonnet gravity
- Author
-
Yerra, Pavan Kumar and Bhamidipati, Chandrasekhar
- Subjects
General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
The topological classification of critical points of black holes in 4D Einstein-Gauss-Bonnet gravity coupled to Born-Infeld theory is investigated. Considered independently, Born-infeld corrections to the Einstein action alter the topological charge of critical points of the charged AdS black hole system, whereas the Gauss-Bonnet corrections do not. For the combined system though, the total topological charge of the Einstein-Gauss-Bonnet theory is unaltered in the presence of Born-Infeld coupling., Comment: v1: 14 pages, 5 figures; v2: 17 pages, 7 figures, minor changes, matches published version
- Published
- 2022
- Full Text
- View/download PDF
142. A Generalized Framework for Microstructural Optimization using Neural Networks
- Author
-
Sridhara, Saketh, Chandrasekhar, Aaditya, and Suresh, Krishnan
- Subjects
Condensed Matter - Materials Science ,Computer Science - Computational Engineering, Finance, and Science ,Computer Science - Machine Learning - Abstract
Microstructures, i.e., architected materials, are designed today, typically, by maximizing an objective, such as bulk modulus, subject to a volume constraint. However, in many applications, it is often more appropriate to impose constraints on other physical quantities of interest. In this paper, we consider such generalized microstructural optimization problems where any of the microstructural quantities, namely, bulk, shear, Poisson ratio, or volume, can serve as the objective, while the remaining can serve as constraints. In particular, we propose here a neural-network (NN) framework to solve such problems. The framework relies on the classic density formulation of microstructural optimization, but the density field is represented through the NN's weights and biases. The main characteristics of the proposed NN framework are: (1) it supports automatic differentiation, eliminating the need for manual sensitivity derivations, (2) smoothing filters are not required due to implicit filtering, (3) the framework can be easily extended to multiple-materials, and (4) a high-resolution microstructural topology can be recovered through a simple post-processing step. The framework is illustrated through a variety of microstructural optimization problems.
- Published
- 2022
143. Logarithmic corrections to black hole entropy and holography
- Author
-
Ghosh, Aritra, Bhamidipati, Chandrasekhar, and Mukherji, Sudipta
- Subjects
High Energy Physics - Theory ,General Relativity and Quantum Cosmology - Abstract
We compute logarithmic corrections to the black hole entropy $S_{\rm bh}$ in a holographic set up where the cosmological constant $\Lambda$ and Newton's constant $G_D$ are taken to be thermodynamic parameters, related to variations in bulk pressure \(P\) and central charge \(c\). In the bulk, the logarithmic corrections are of the form: $\mathcal{S} = S_{\rm bh} - k \ln S_{\rm bh} + \cdots$ arising due to fluctuations in thermodynamic volume, induced by a variable $\Lambda$, in addition to energy fluctuations. We explicitly compute this coefficient $k$ for the BTZ black hole and show that the result matches with the one coming from the logarithmic corrections to the Cardy's formula. We propose an entropy function in the CFT, which exactly reproduces the logarithmic corrections to black hole entropy in arbitrary dimensions., Comment: 5 pages
- Published
- 2022
144. Monitoring response to a clinically relevant IDH inhibitor in glioma—Hyperpolarized 13C magnetic resonance spectroscopy approaches
- Author
-
Hong, Donghyun, Kim, Yaewon, Mushti, Chandrasekhar, Minami, Noriaki, Wu, Jing, Cherukuri, Murali Krishna, Swenson, Rolf E, Vigneron, Daniel B, and Ronen, Sabrina M
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Brain Disorders ,Cancer ,Biomedical Imaging ,Rare Diseases ,hyperpolarized 13C MRS ,IDH inhibitor ,imaging biomarker ,mutant IDH glioma ,therapeutic response - Abstract
BackgroundMutant isocitrate dehydrogenase (IDHmut) catalyzes 2-hydroxyglutarate (2HG) production and is considered a therapeutic target for IDHmut tumors. However, response is mostly associated with inhibition of tumor growth. Response assessment via anatomic imaging is therefore challenging. Our goal was to directly detect IDHmut inhibition using a new hyperpolarized (HP) 13C magnetic resonance spectroscopy-based approach to noninvasively assess α-ketoglutarate (αKG) metabolism to 2HG and glutamate.MethodsWe studied IDHmut-expressing normal human astrocyte (NHAIDH1mut) cells and rats with BT257 tumors, and assessed response to the IDHmut inhibitor BAY-1436032 (n ≥ 4). We developed a new 13C Echo Planar Spectroscopic Imaging sequence with an optimized RF pulse to monitor the fate of HP [1-13C]αKG and [5-12C,1-13C]αKG with a 2.5 × 2.5 × 8 mm3 spatial resolution.ResultsCell studies confirmed that BAY-1436032-treatment leads to a drop in HP 2HG and an increase in HP glutamate detectable with both HP substrates. Data using HP [5-12C,1-13C]αKG also demonstrated that its conversion to 2HG is detectable without the proximal 1.1% natural abundance [5-13C]αKG signal. In vivo studies showed that glutamate is produced in normal brains but no 2HG is detectable. In tumor-bearing rats, we detected the production of both 2HG and glutamate, and BAY-1436032-treatment led to a drop in 2HG and an increase in glutamate. Using HP [5-12C,1-13C]αKG we detected metabolism with an signal-to-noise ratio of 23 for 2HG and 17 for glutamate.ConclusionsOur findings point to the clinical potential of HP αKG, which recently received FDA investigational new drug approval for research, for noninvasive localized imaging of IDHmut status.
- Published
- 2023
145. Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis
- Author
-
Mukhtar, Tanzila, Breda, Jeremie, Adam, Manal A, Boareto, Marcelo, Grobecker, Pascal, Karimaddini, Zahra, Grison, Alice, Eschbach, Katja, Chandrasekhar, Ramakrishnan, Vermeul, Swen, Okoniewski, Michal, Pachkov, Mikhail, Harwell, Corey C, Atanasoski, Suzana, Beisel, Christian, Iber, Dagmar, Nimwegen, Erik, and Taylor, Verdon
- Subjects
Biomedical and Clinical Sciences ,Stem Cell Research ,Stem Cell Research - Nonembryonic - Non-Human ,Regenerative Medicine ,Stem Cell Research - Embryonic - Non-Human ,Genetics ,Neurosciences ,Brain Disorders ,Intellectual and Developmental Disabilities (IDD) ,1.1 Normal biological development and functioning ,Underpinning research ,Neurological ,Animals ,Mice ,Cell Differentiation ,Cell Lineage ,Cerebral Cortex ,Embryonic Stem Cells ,Neural Stem Cells ,Neurogenesis ,Neurons ,cortical development ,lineage specification ,networks ,signaling pathways ,transcriptional landscape ,Biological Sciences ,Information and Computing Sciences ,Medical and Health Sciences ,Developmental Biology ,Biological sciences ,Biomedical and clinical sciences - Abstract
The cerebral cortex contains billions of neurons, and their disorganization or misspecification leads to neurodevelopmental disorders. Understanding how the plethora of projection neuron subtypes are generated by cortical neural stem cells (NSCs) is a major challenge. Here, we focused on elucidating the transcriptional landscape of murine embryonic NSCs, basal progenitors (BPs), and newborn neurons (NBNs) throughout cortical development. We uncover dynamic shifts in transcriptional space over time and heterogeneity within each progenitor population. We identified signature hallmarks of NSC, BP, and NBN clusters and predict active transcriptional nodes and networks that contribute to neural fate specification. We find that the expression of receptors, ligands, and downstream pathway components is highly dynamic over time and throughout the lineage implying differential responsiveness to signals. Thus, we provide an expansive compendium of gene expression during cortical development that will be an invaluable resource for studying neural developmental processes and neurodevelopmental disorders.
- Published
- 2022
146. The roles of TGF-β and VEGF pathways in the suppression of antitumor immunity in melanoma and other solid tumors.
- Author
-
Bu, Melissa, Chandrasekhar, Pallavi, Ding, Lizhong, and Hugo, Willy
- Subjects
Angiogenesis ,Bispecific antibody ,Combination immunotherapy ,Fibrosis ,Immunosuppressive tumor microenvironment ,Immunotherapy resistance ,Trap antibody ,Wound healing ,Humans ,Programmed Cell Death 1 Receptor ,Transforming Growth Factor beta ,Vascular Endothelial Growth Factor A ,Neoplasms ,Immunotherapy ,Tumor Microenvironment ,Melanoma ,Antibodies - Abstract
Immune checkpoint blockade (ICB) has become well-known in cancer therapy, strengthening the bodys antitumor immune response rather than directly targeting cancer cells. Therapies targeting immune inhibitory checkpoints, such as PD-1, PD-L1, and CTLA-4, have resulted in impressive clinical responses across different types of solid tumors. However, as with other types of cancer treatments, ICB-based immunotherapy is hampered by both innate and acquired drug resistance. We previously reported the enrichment of gene signatures associated with wound healing, epithelial-to-mesenchymal, and angiogenesis processes in the tumors of patients with innate resistance to PD-1 checkpoint antibody therapy; we termed these the Innate Anti-PD-1 Resistance Signatures (IPRES). The TGF-β and VEGFA pathways emerge as the dominant drivers of IPRES-associated processes. Here, we review these pathways functions, their roles in immunosuppression, and the currently available therapies that target them. We also discuss recent developments in the targeting of TGF-β using a specific antibody class termed trap antibody. The application of trap antibodies opens the promise of localized targeting of the TGF-β and VEGFA pathways within the tumor microenvironment. Such specificity may offer an enhanced therapeutic window that enables suppression of the IPRES processes in the tumor microenvironment while sparing the normal homeostatic functions of TGF-β and VEGFA in healthy tissues.
- Published
- 2022
147. Therapeutic potential of [177Lu]Lu-DOTAGA-FAPi dimers in metastatic breast cancer patients with limited treatment options: efficacy and safety assessment
- Author
-
Yadav, Madhav P., Ballal, Sanjana, Martin, Marcel, Roesch, Frank, Satapathy, Swayamjeet, Moon, Euy S., Tripathi, Madhavi, Gogia, Ajay, and Bal, Chandrasekhar
- Published
- 2024
- Full Text
- View/download PDF
148. A prospective study of 68Ga-PSMA PET/CT imaging of HCC as diagnosed on conventional imaging to evaluate for potential 177Lu-PSMA therapy
- Author
-
Shamim, Shamim Ahmed, Kumar, Naresh, Arora, Geetanjali, Jaswal, Sahil, Shalimar, Gamanagatti, Shivanand, and Bal, Chandrasekhar
- Published
- 2024
- Full Text
- View/download PDF
149. An optimized MCHVD approach to curtail handover failures in wireless networks
- Author
-
Gupta, Sachin, Deepak, Shashikant, Bhuvana, J., Singh, Vaishali, Jindal, Kanika, Vekariya, Vipul, Chandrasekhar, Malepati, and Narula, Gagandeep Singh
- Published
- 2024
- Full Text
- View/download PDF
150. Current Standards, Multidisciplinary Approaches, and Future Directions in the Management of Extrahepatic Cholangiocarcinoma
- Author
-
Wheless, Margaret, Agarwal, Rajiv, Goff, Laura, Lockney, Natalie, Padmanabhan, Chandrasekhar, and Heumann, Thatcher
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.