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The current study aimed to examine the relationship between sensory processing skills and feeding behavior in cerebral palsy (CP) children aged 3–6 years with cerebral visual impairment (CVI). A total of ninety mothers participated in the study in three groups: thirty mothers of children with CP with CVI, thirty mothers of children with CP without CVI, and thirty mothers of children with typical development (TD). The sensory processing skill of the children was evaluated with the Sensory Profile (SP), and feeding behavior was evaluated with the the Behavioral Pediatric Feeding Assessment Scale (BPFAS). In the triple comparison, a significant difference was found between the groups in all SP parameter and BPFAS scores (p < 0.001). Post hoc analysis revealed statistically significant differences between the groups in all parameters (p < 0.001). Feeding problems were detected in 65% of all groups. In the correlation analysis, a significant relationship was found between all parameters of the SP and the BPFAS (p < 0.05). In terms of sensory processing skills and feeding status, it was determined that children with CVI with CP had more problems than children with CP without CVI, and children with CP without CVI had more problems than children with TD. With these results, it was concluded that sensory processing problems affect feeding status, and visual impairment causes both sensory problems and feeding problems.

Abstract Pesticides are toxic chemicals used to control pests, plant diseases, or undesirable vegetation. Trifluralin (TRF), causing toxicity and mutagenicity, is a dinitroaniline class herbicide used to control undesirable vegetation in agriculture. Aloe vera is a widely used plant having rich gel content and a wide area of utilization. The present study aims to investigate the protective effect of Aloe vera on Drosophila melanogaster toxicity caused by TRF. For this purpose, life span, larval toxicity, and genotoxicity tests were performed on D. melanogaster administered with concentration of TRF (0.1 mM) and Aloe vera (2.5%, 5% and 10%). The results showed that life span was improved in the female and male populations when TRF and Aloe vera was administered (2.5%, 5% and 10%). Furthermore, the larval toxicity experiment showed that TRF decreased the survival rate of larvae; however, TRF and Aloe vera (10%) increased it at the highest concentration. According to the Comet Assay, TRF was found to cause an increase in the DNA damage; on the other hand, when D. melanogaster was administered with TRF and Aloe vera, the DNA damage decreased gradually in a dose-dependent manner. In conclusion, Aloe vera could be a good candidate to reduce the harmful effects of TRF, one of the most used herbicides.

ABSTRACT Objective: This study aimed to evaluate the effects of systemic teriparatide on sutural bone formation after premaxillary suture expansion in rats. Material and Methods: Twenty Wistar male rats (8-10 weeks old) were randomly divided into two groups, namely, control (C, n=10) and teriparatide (T, n=10). An expansion force was applied to the maxillary incisors using helical spring for a seven-day expansion period, for both groups. On the eighth day, the rats were kept for a seven-day consolidation period, and then 60 µg/kg teriparatide (once a day) was administered to group T subcutaneously for seven days. Then, all the rats were sacrificed, and histological sections were stained with hemotoxylin-eosin for examination. Anti-osteonectin, anti-osteocalcin, anti-Vascular endothelial growth factor (VEGF) and anti-transforming growth factor beta (TGF-β) were evaluated by immunohistochemical analysis in the midpalatal suture area. Results: Histologically, the newly formed bone tissue was observed to be larger in group T than in group C. The number of immunoreactive osteoblasts for osteonectin, osteocalcin and VEGF antibodies was significantly higher in group T than in group C (p = 0.0001). The TGF-β antibody showed a mild reaction in group T, but did not reach significance in comparison with group C (p ˃ 0.05). Conclusion: Systemic teriparatide application following the premaxillary expansion of the suture area may stimulate bone formation and add to the consolidation of the expansion in rats by regulating osteonectin, osteocalcin and VEGF.

This study provides an extensive discussion on how collective entrepreneurship strategies by multiple organizational actors both within and across sectors can yield innovative solutions to several problems. Although the emphasis in the entrepreneurship literature has been largely on initiatives by single actors, combinations and complementarities of resources through partnerships can significantly help produce novel approaches to the ongoing socioeconomic, environmental, political and institutional challenges. How such collective entrepreneurial systems are developed, what the main collaboration dynamics among actors are, how these systems can be managed, and when and where such collective action can produce innovative results are only a few of the curious questions to answer. An important aspect is to understand how seemingly unrelated actors across diverse sectors collaborate. To this end, this study provides an inclusive theoretical framework on how collective entrepreneurial action stimulates innovative outcomes for organizations by evaluating the level, type and characteristics of entrepreneurial collectives. Even though there has been increasing interest in collective entrepreneurship, this is the first attempt where an integrated model is provided to understand this essential phenomenon.

Myocarditis contributes to the global burden of cardiovascular disease mainly through sudden death and chronic cardiomyopathy in young age groups. Monocyte/high-density lipoprotein cholesterol (HDL-C) ratio (MHR) has developed as a new inflammation biomarker. In this study has investigated that relationship between admission MHR levels and the reduced left ventricular systolic functions after acute myocarditis. The study included a total of 156 consecutive cases wanted by their doctors to undergo cardiovascular magnetic resonance imaging for acute myocarditis as the clinical diagnosis between 2009 and 2017 at our hospital. Study participants were split into two groups; group I patients (patients with LVEF [Med-Science 2021; 10(2.000): 304-9]

Most mutant p53 heterozygous tumours undergo loss of the remaining wildtype (WT) p53 allele which leads to stabilization of the mutant p53 protein. Here, the authors show in an autochthonous colorectal cancer model that the WT p53 allele retains partial activity and suppresses the heat shock factor 1 (HSF1)- chaperone axis to prevent mutant p53 stabilisation and mutant p53 gain-of-function activities, thereby creating selective pressure for p53 loss-of-heterozygosity.

To prevent occupational accidents and occupational diseases Occupational Health and Safety Law No. 6331 came into force on 20 June 2012. The law was prepared on the basis of proactive approach by considering all fields of activities and all employees from both public and private sector. Both this law and the “Occupational Health and Safety Risk Assessment Regulation” which issued on the basis of this subject obliged employers to make or have a risk assessment at all workplaces. In this study, risk assessment with Fine-Kinney method is examined in the administrative buildings of a large-scale production enterprise. A checklist (hazards) has been developed for each of the 7 types of places in the buildings: office, corridor, WC, tea house, meeting room, training hall and elevator. A total of 110 hazards were analyzed for 311 locations, and 1,199 risk assessments were performed using Fine-Kinney method. It was determined that hazards in the high risk category are 34.36% in offices and 12.43% in corridors

maç: Bu çalışmda melatonin ön-tedavisinin, sıçanlarda mide ülserine bağlı gerçekleşen mikrobiyota değişimine ve oksidatif hasara karşı koruyucu etkilerini araştırmak hedeflenmiştir. Gereç ve Yöntem: Wistar albino sıçanlara (n=32) 12 gün boyunca içme suyu, melatonin (4mg/kg/gün), antibiyotik karışımı (AB; 1 g/L ampisilin + 1 g/L neomisin+ 1 g/L metronidazol), melatonin+ AB içme suyunda verildi. Ardından ülser oluşturuldu. Katkısız içme suyu alan sıçanların yarısına cerrahi işlem yapıldı ama asetik asit uygulanmadı (kontrol grubu; n=8). Cerrahi sonrasındaki 3 gün boyunca uygulanan tüm tedavilere devam edildi. Mide dokuları biyokimyasal ve histopatolojik incelemeler için çıkarıldı. Rektumdan alınan fekal örnekler bakteriyolojik ölçümler için uygun koşullarda saklandı. Bulgular: Tedavi almayan ülser grubunun mide dokusunda MDA, MPO, 8-OHdG, luminol ve lusigenin kemilüminesans seviyeleri, TNF-α ve IL-8 protein ekspresyonları kontrol grubuna göre anlamlı derecede artarken, antioksidan GSH seviyesinin azaldığı gözlendi. Melatonin+AB ön-tedavi uygulaması antioksidan GSH seviyesini ve anti-inflamatuvar IL-10 miktarını artırmış, kaspaz-3 aktivitesini baskılamış ve dokuya nötrofil göçünü kontrol düzeyine inecek şekilde azaltmıştır. Sonuç: Etkin bir antioksidan ve radikal süpürücü olan melatoninin antibiyotik ile birlikte verilmesinin, ülser iyileşmesini hızlandırmada ve kolondaki dağılımı bozulan bakteriyel çeşitliliği düzeltmede daha etkili olacağı öngörülmektedir.

Abstract Background In the clinical setting, workflows for analyzing individual genomics data should be both comprehensive and convenient for clinical interpretation. In an effort for comprehensiveness and practicality, we attempted to create a clinical individual whole exome sequencing (WES) analysis workflow, allowing identification of genomic alterations and presentation of neurooncologically-relevant findings. Methods The analysis workflow detects germline and somatic variants and presents: (1) germline variants, (2) somatic short variants, (3) tumor mutational burden (TMB), (4) microsatellite instability (MSI), (5) somatic copy number alterations (SCNA), (6) SCNA burden, (7) loss of heterozygosity, (8) genes with double-hit, (9) mutational signatures, and (10) pathway enrichment analyses. Using the workflow, 58 WES analyses from matched blood and tumor samples of 52 patients were analyzed: 47 primary and 11 recurrent diffuse gliomas. Results The median mean read depths were 199.88 for tumor and 110.955 for normal samples. For germline variants, a median of 22 (14–33) variants per patient was reported. There was a median of 6 (0–590) reported somatic short variants per tumor. A median of 19 (0–94) broad SCNAs and a median of 6 (0–12) gene-level SCNAs were reported per tumor. The gene with the most frequent somatic short variants was TP53 (41.38%). The most frequent chromosome-/arm-level SCNA events were chr7 amplification, chr22q loss, and chr10 loss. TMB in primary gliomas were significantly lower than in recurrent tumors (p = 0.002). MSI incidence was low (6.9%). Conclusions We demonstrate that WES can be practically and efficiently utilized for clinical analysis of individual brain tumors. The results display that NOTATES produces clinically relevant results in a concise but exhaustive manner.

Steroids are frequently used for symptom control in cases of asthma exacerbation. The aim of this study was to compare the effect of short-term and long-term oral steroid therapy on symptom control in patients with asthma exacerbation. Patients that received short-term (

Institutionalization is defined as the process of bringing a new word in the society speaking the language. Nonce words are the first step of the institutionalization process. Words that appear in a language at least once in a particular context, yet are not adopted by language speakers, are called nonce formations. A nonce word is institutionalized if it becomes widespread to a certain extent. No comprehensive and detailed study exists on the process of institutionalization and the scaling of this process in the literature. To this end, this study aims to find out words which are in the process of institutionalization, to reveal how close they are to the lexicalization process, and to determine whether the word formation methods and derivational morphemes in the words in this process are parallel to the typological data by a statistical measurement applied on the frequency of use. First, words in the institutionalization process have been determined, and then in order to determine the institutionalization ratios of the words examined, the Turkish National Corpus 3.0. has been used. Institutionalization ratios are divided into three basic sets by means of a quartile analysis applied on the frequency values of the words. Q1 set with geyikle- and ebelemeç covers those that are relatively least institutionalized; Q2 covers a set moderately institutionalized such as tırcı and negzel, words; The set of Q3 covers the words that are the closest analysis value to lexicalization in the process of institutionalization, such as tırsak and terso. Of the words in the sample, 52.9% have been derived by affixation, evenly with 7.8% by borrowing, clipping, compounding and onomatopoeia. The most common derivative morphemes are -CI and -lIk, but these morphemes have not been among the words in the final stage of institutionalization.

Reported speech/quotations are used to insert other voices in texts, resulting in a form of intertextuality. With this characteristic, they are a form of intertextuality. Reporting can be through direct, indirect, strategic, transformed indirect and ostensible direct quotations and these involve ideological implications since they are closely related to evaluation and assessment. In this study, different types of reported speech and their discursive functions have been studied within the framework of Critical Discourse Analysis in the op-ed articles in nine different newspapers known to be the representatives of different political ideologies. According to the findings of the study, direct quotations are the most frequently used type of reported speech and they are followed by indirect quotations in all types of ideologies. Considering type and ideology relationship, it has been found that writers of secular ideology use direct, strategical and transformed indirect quotations more frequently than the others. On the other hand, indirect and ostensible direct quotations are used more frequently in Islamist ideology. Regarding their discursive functions, writers use quotations to realize different aims: tangibly supporting their arguments to make themselves more creditable, increase the reliability of their arguments, legitimize/validate their own statements; dramatizing events; evading responsibility by distancing themselves from the source of information; describing and disparaging the characteristics of the person they quote or report; bringing the opposing opinions to the attention of the readers; providing the background of a piece of information; describing the characteristics of the person quoted and praising them.

Abstract: The translation literature indicates a negative perception regarding the translator status and the translation profession. This study aims to explore how the state and private sector translators’ social, symbolic, cultural capital and translatorial habitus are related to their self-perceptions of status as a professional group in Turkey. With this aim in mind, semi-structured in-depth interviews were conducted with thirteen translators who work in the state and private sectors in Turkey. The results of the interviews are discussed in the light of Pierre Bourdieu’s key concepts of capital and habitus. According to the findings of the study, translation is not still a fully established profession in Turkey. The findings also indicate that translators don't assign the same value to all the capital forms. Especially the possession of a distinctive cultural capital in an unregulated field leads them to develop a professional habitus of proud, satisfied, committed experts. In light of the qualitative findings this study argues that the social negative narratives regarding the translation profession in Turkey clash with the translators’ personal narratives in terms of their social, symbolic, cultural capital and translatorial habitus. Öz: Çeviribilim araştırmalarında çevirmen statüsü ve çevirmenlik mesleğine ilişkin olumsuz bir algı söz konusudur. Bu çalışmanın amacı Türkiye’de özel sektörde ve kamu sektöründe çalışan çevirmenlerin bir meslek grubu olarak statülerine yönelik öz algılarının sosyal, sembolik, kültürel sermayeleri ve çevirmen habituslarıyla ilişkisini araştırmaktır. Bu amaç doğrultusunda, özel sektörde ve kamu sektöründe çalışan toplam 13 çevirmen ile yarı yapılandırılmış görüşmeler yapılmıştır. Bu görüşmelerin verileri Pierre Bourdieu’nun habitus ve sermaye kavramları ışığında incelenmiştir. Araştırma sonuçlarına göre, Türkiye’de çevirmenlikte meslekleşme süreci tamamlanmış değildir. Ayrıca araştırma sonuçları, çevirmenlerin farklı sermaye türlerine eşit derecede değer vermediklerine işaret etmektedir. Özellikle düzenlemelerin eksik olduğu bir alanda ayırt edici bir kültürel sermayeye sahip olmaları, çevirmenlerin işiyle gurur duyun, iş tatmini yüksek, kendini mesleğe adamış uzman şeklinde bir mesleki habitus geliştirmesine yol açmaktadır. Araştırma Türkiye’de çevirmenlik mesleğine ilişkin olumsuz toplumsal anlaıların, çevirmenlerin sosyal, sembolik, kültürel ve çevirmenlik habitusları açısından kişisel anlatıları ile çatışmakta olduğunu savunmaktadır.

Abstract Background Platelets play a central role in the development of cardiovascular diseases and changes in their proteins are involved in the pathophysiology of heart diseases in humans. There is lack of knowledge about the possible role of platelets in congestive heart failure (CHF) in dogs. Thus, this study aimed to investigate the changes in global platelet proteomes in dogs with CHF, to clarify the possible role of platelets in the physiopathology of this disease. Healthy-dogs (n = 10) and dogs with acute CHF due to myxomatous mitral valve disease (MMVD, n = 10) were used. Acute CHF was defined based on the clinical (increased respiratory rate or difficulty breathing) and radiographic findings of pulmonary edema. Dogs Blood samples were collected into tubes with acid-citrate-dextrose, and platelet-pellets were obtained by centrifuge and washing steps. Platelet-proteomes were identified using LC-MS based label-free differential proteome expression analysis method and matched according to protein database for Canis lupus familiaris. Results Totally 104 different proteins were identified in the platelets of the dogs being 4 out of them were significantly up-regulated and 6 down-regulated in acute CHF dogs. Guanine-nucleotide-binding protein, apolipoproteins (A-II and C-III) and clusterin levels increased, but CXC-motif-chemokine-10, cytochrome-C-oxidase-subunit-2, cathepsin-D, serine/threonine-protein-phosphatase-PP1-gamma-catalytic-subunit, creatine-kinase-B-type and myotrophin levels decreased in acute CHF dogs. These proteins are associated with several molecular functions, biological processes, signaling systems and immune-inflammatory responses. Conclusion This study describes by first time the changes in the protein composition in platelets of dogs with acute CHF due to MMVD. Our findings provide a resource for increase the knowledge about the proteome of canine platelets and their roles in CHF caused by MMVD and could be a tool for further investigations about the prevention and treatment of this disease.