1,306 results on '"Ouaissi A"'
Search Results
102. Hepatobiliary and Pancreatic: A rare form of autoimmune pancreatitis mimicking mixed‐type intraductal papillary mucinous neoplasm
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Vanbrugghe, C, Tabchouri, N, Louis, G, Del Grande, J, Lagrange, X, Turrini, O, and Ouaissi, M
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- 2018
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103. Associations between the severity of medical and surgical complications and perception of surgeon empathy in esophageal and gastric cancer patients
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Gehenne, Lucie, Lelorain, Sophie, Eveno, Clarisse, Piessen, Guillaume, Mariette, Christophe, Glehen, Olivier, d'Journo, Xavier, Mathonnet, Muriel, Regenet, Nicolas, Meunier, Bernard, Baudry, Anne-Sophie, Christophe, Véronique, Adenis, Antoine, Aparicio, Thomas, Assenat, Eric, Barret, Maximilien, Benhaim, Leonor, Benoit, Céline, Bergeat, Damien, Boige, Valérie, Borie, Fréderic, Bouche, Olivier, Bourriez, Damien, Brichon, Pierre-Yves, Brigand, Cécile, Carrere, Nicolas, Cattan, Pierre, Christou, Niki, Coffin, Benoit, Cohen, Romain, Collet, Denis, Conroy, Thierry, Dahan, Laetitia, Deguelte, Sophie, Di Fiore, Fréderic, Dousset, Bertrand, Drouillard, Antoine, Dumont, Frédéric, Elhajbi, Farid, Fabre, Jean Michel, Fabre, Joseph, Gagniere, Johan, Galais, Marie Pierre, Germain, Adeline, Geyl, Sophie, Goere, Diane, Gornet, Jean Marc, Granger, Victoire, Gronnier, Caroline, Guimbaud, Rosine, Hautefeuille, Vincent, Helyon, Morgane, Jougon, Jacques, Lebreton, Gilles, Lefevre, Jérémie, Lepage, Côme, Lievre, Astrid, Marchal, Frédéric, Mathieu, Pierre, Mathysiak, Tamara, Michot, Nicolas, Moszkowicz, David, Moussata, Driffa, Msika, Simon, Neuzillet, Cindy, Ouaissi, Medhi, Paquette, Brice, Paye, François, Penna, Christophe, Père, Guillaume, Perrier, Marine, Peschaud, Frédérique, Pezet, Denis, Phoutthsang, Valérie, Pocard, Marc, Rat, Paul, Regimbeau, Jean Marc, Renaud, Florence, Sabate, Jean-Marc, Souche, Régis, Terrebonne, Eric, Tessier, Williams, Thomas, Pascal Alexandre, Turpin, Anthony, Vaudoyer, Delphine, Vienot, Angélique, Voron, Thibault, You, Benoit, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], CHU Limoges, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Pontchaillou [Rennes], Centre hospitalier [Valenciennes, Nord], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
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medicine.medical_specialty ,Esophageal Neoplasms ,media_common.quotation_subject ,education ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Empathy ,MESH: Perception ,Odds ,Postoperative complications ,MESH: Surgeons ,03 medical and health sciences ,0302 clinical medicine ,Stomach Neoplasms ,Perception ,Internal medicine ,Humans ,Medicine ,030212 general & internal medicine ,Major complication ,Retrospective Studies ,Cancer ,media_common ,Multinomial logistic regression ,Surgeons ,Physician-Patient Relations ,MESH: Humans ,business.industry ,Nursing research ,MESH: Retrospective Studies ,Cognition ,MESH: Stomach Neoplasms ,medicine.disease ,Patient-physician communication ,MESH: Empathy ,Oncology ,030220 oncology & carcinogenesis ,MESH: Esophageal Neoplasms ,MESH: Physician-Patient Relations ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Objective: To assess the impact of global physician empathy and its three subdimensions (establishing rapport, emotional and cognitive processes) on the severity of postoperative complications in a sample of cancer patients.Methods: We retrospectively analyzed data on 256 patients with esogastric cancer from the French national FREGAT database. Empathy and its subdimensions were assessed using the patient-reported CARE scale and the severity of medical and surgical complications was reported with the Clavien-Dindo classification system. The usual covariates were included in multinomial logistic regression analyses.Results: Physician empathy predicted the odds of reporting major complications. When patients perceived high empathy, they were less likely to report major complications compared to no complications (OR = .95, 95% CI = [.91-.99], p = .029). Among the three dimensions, only "establishing rapport" (OR = .84, 95% CI = [.73-.98], p = .019) and the "emotional process" (OR = .85, 95% CI = [.74-.98], p = .022) predicted major complications.Conclusions: Physician empathy is essential before surgery. Further research is needed to understand the mechanisms associating empathy with health outcomes in cancer. Physicians should be trained to establish good rapport with patients, especially in the preoperative period.
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- 2021
104. ASO Visual Abstract: Safety and Feasibility of High Pressure/High Dose Pressurized Intraperitoneal Aerosol Chemotherapy (HP/HD-PIPAC) for Primary and Metastatic Peritoneal Surface Malignancies
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Ramos Arias Gabriel, Rémy Sindayigaya, Mehdi Ouaissi, Jonathan R. Buggisch, Maximilian Schmeding, Urs Giger-Pabst, and Jürgen Zieren
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Oncology ,Surgery - Published
- 2023
105. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for the treatment of malignant mesothelioma
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Giger-Pabst, Urs, Demtröder, Cédric, Falkenstein, Thomas A., Ouaissi, Mehdi, Götze, Thorsten O., Rezniczek, Günther A., and Tempfer, Clemens B.
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- 2018
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106. Outcomes and Side Effects of Preoperative Chemoradiotherapy for Locally Advanced Upper Rectal Cancer
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SANDRA CHOMICKI, SOPHIE CHAPET, MOUSSATA DRIFA, MEHDI OUAISSI, PASCAL BOURLIER, KAMEL DEBBI, GOKOULAKRICHENANE LOGANADANE, and GILLES CALAIS
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Cancer Research ,Treatment Outcome ,Oncology ,Rectal Neoplasms ,Humans ,General Medicine ,Chemoradiotherapy ,Neoplasm Recurrence, Local ,Disease-Free Survival ,Neoadjuvant Therapy ,Neoplasm Staging ,Retrospective Studies - Abstract
The benefit of neoadjuvant (chemo) radiotherapy for locally advanced upper rectal tumors remains controversial. Thus, we aimed to evaluate the outcome of patients with stage II or-III upper rectal cancer undergoing neoadjuvant (chemo) radiotherapy followed by total mesorectal excision in our institution.From April 2004 to October 2019, all patients with stage II or III upper rectal cancer treated with neoadjuvant (chemo) radiotherapy followed by total mesorectal excision were identified from our database. Overall survival, progression-free survival, and local recurrence were assessed using the Kaplan-Meier method. Acute and late treatment-related toxicities were recorded according to the CTCAE-5 version.The study group consisted of 106 patients. Respectively, 36% and 61% of patients had stage II and stage III upper rectal cancer. The median follow-up period was 4.4 ± 3.4 years. Five-year overall survival and progression-free survival were respectively 78% [95% confidence interval (CI)=69.2-88] and 76.8% (95%CI=68.4-86.2). The rate of local recurrence at 5 years was 3.78% (95%CI=0-7.98). Forty-two percent of patients presented early toxicities and 27.4% of patients experienced early surgical complications. Late toxicities and surgical complications occurred in 24.5% and 9.4% of patients, respectively.Neoadjuvant (chemo) radiotherapy followed by total mesorectal excision of stage II-III upper rectal cancer is effective and safe.
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- 2022
107. Long term outcome of multidisciplinary management of urethro-rectal fistula after urologic surgery
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P. Jeannot, B. Faivre d’Arcier, V. Bridoux, E. Salamé, F. Bruyère, and M. Ouaissi
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General Medicine - Abstract
Urethro-rectal fistula (URF) is a rare but serious condition whose treatment is poorly codified. This study aims to evaluate the short and long-term results of multidisciplinary management.We retrospectively collected the records of patients with URF operated on at the University Hospital of Tours between January 1, 2000 and January 1, 2020. Short-term and long-term results according to management are reported.The study included 20 patients. As an initial gesture, 11 patients underwent bladder catheterization and colostomy, seven underwent bladder catheterization alone, one underwent graciloplasty, and one, a York Mason procedure. The success rate of initial conservative management was only 5% (1/20). As a secondary or tertiary intervention, ten patients underwent a York Mason procedure and nine underwent graciloplasty. At the end of the study period, with a median follow-up of 50 months, 19 had been effectively treated for URF, 16 were able to have colostomy closure with restoration of digestive continuity while four had a permanent stoma. One patient had anal incontinence, 14% had major stress urinary incontinence.Multidisciplinary care remains a cornerstone of the treatment of URF because iterative surgeries may be required, with an overall success rate of up to 95% at the end of follow-up.
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- 2022
108. Curcumin and NCLX inhibitors share anti-tumoral mechanisms in microsatellite-instability-driven colorectal cancer
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Maxime Guéguinou, Sajida Ibrahim, Jérôme Bourgeais, Alison Robert, Trayambak Pathak, Xuexin Zhang, David Crottès, Jacques Dupuy, David Ternant, Valérie Monbet, Roseline Guibon, Hector Flores-Romero, Antoine Lefèvre, Stéphanie Lerondel, Alain Le Pape, Jean-François Dumas, Philippe G. Frank, Alban Girault, Romain Chautard, Françoise Guéraud, Ana J. García-Sáez, Mehdi Ouaissi, Patrick Emond, Olivier Sire, Olivier Hérault, Gaëlle Fromont-Hankard, Christophe Vandier, David Tougeron, Mohamed Trebak, William Raoul, Thierry Lecomte, Nutrition, croissance et cancer (U 1069) (N2C), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT), ERL 7001 LNOx (Leukemic Niche & redOx metabolism / Niche leucémique et métabolisme redOx) (LNOx), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Centre National de la Recherche Scientifique (CNRS)-Microenvironnement des niches tumorales (CNRS GDR 3697 Micronit ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Groupe innovation et ciblage cellulaire (GICC), EA 7501 [2018-...] (GICC EA 7501), Université de Tours (UT)-Université de Tours (UT), Pennsylvania State University (Penn State), Penn State System, Prévention et promotion de la cancérogénèse par les aliments (ToxAlim-PPCA), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), EA4245 - Transplantation, Immunologie, Inflammation [Tours] (T2i), Institut de Recherche Mathématique de Rennes (IRMAR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École normale supérieure - Rennes (ENS Rennes)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-INSTITUT AGRO Agrocampus Ouest, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), University of Cologne, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Imagerie et cerveau (iBrain - Inserm U1253 - UNIV Tours ), Transgenèse et archivage d'animaux modèles (TAAM), Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physiologie Cellulaire et Moléculaire - UR UPJV 4667 (LPCM), Université de Picardie Jules Verne (UPJV), Institut de Recherche Dupuy de Lôme (IRDL), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Université de Poitiers - Faculté de Médecine et de Pharmacie, Université de Poitiers, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), This project was partly supported by grants on behalf of the following french department committees of Ligue Contre le Cancer Grand-Ouest: 16 (Charente), 37 (Indre-et-Loire), 49 (Maine-et-Loire), 72 (Sarthe) and 85 (Vendée), ANR-11-LABX-0020,LEBESGUE,Centre de Mathématiques Henri Lebesgue : fondements, interactions, applications et Formation(2011), LESUR, Hélène, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
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Pharmacology ,Curcumin ,[SDV]Life Sciences [q-bio] ,Calcium signaling ,Cell Biology ,Colorectal cancer ,Sodium-Calcium Exchanger ,digestive system diseases ,Mitochondria ,Mitochondrial Proteins ,[SDV] Life Sciences [q-bio] ,Mice ,Cellular and Molecular Neuroscience ,Animals ,Humans ,Molecular Medicine ,Calcium ,Microsatellite Instability ,Colorectal Neoplasms ,NCLX ,Molecular Biology ,Microsatellite Repeats - Abstract
Colorectal cancer (CRC) is associated with high mortality worldwide and new targets are needed to overcome treatment resistance. Recent evidences highlight a role of the mitochondria calcium homeostasis in the development of CRC. In this context, we aimed to evaluate the role of the mitochondrial sodium-calcium-lithium exchanger (NCLX) and its targeting in CRC. We also identified curcumin as a new potential inhibitor of NCLX.In vitro, curcumin exerted strong anti-tumoral activity through its action on NCLX with mtCa2+ and reactive oxygen species overload associated with a mitochondrial membrane depolarization, leading to reduced ATP production and apoptosis through mitochondrial permeability transition pore opening concomitant with G2/M cell cycle arrest. NCLX inhibition with either CGP37157 (a benzodiazepine derivative), small interfering RNA-mediated knock-down or knockout approaches reproduced the effects of curcumin. Altered mitochondrial respiration, cellular aerobic glycolysis and endoplasmic reticulum–mitochondria membrane perturbations participated in these mechanisms. In a xenograft mouse model, NCLX inhibitors decreased CRC tumor growth. Both transcriptomic analysis of The Cancer Genome Atlas dataset and immunohistochemical analysis of tissue microarrays from 381 patients with microsatellite instability (MSI)-driven CRC demonstrated that higher NCLX expression was associated with MSI status and for the first time NCLX expression was significantly associated with recurrence-free survival in MSI CRC patients.Our findings provide strong evidence that blocking NCLX inhibits CRC in vitro and in vivo. We highlight a novel anti-tumoral mechanism of curcumin through its action on NCLX and mitochondria calcium overload that could benefit for therapeutic treatment of patients with MSI CRC.
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- 2022
109. Ano‐rectovaginal fistula after obstetrical anal sphincter injury: Diverting stoma does not improve the surgical results
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Venara, Aurélien, primary, Trilling, Bertrand, additional, Ngoma, Marie, additional, Brochard, Charlène, additional, Duchalais, Emilie, additional, Siproudhis, Laurent, additional, Faucheron, Jean‐Luc, additional, de Parades, Vincent, additional, Alves, Arnaud, additional, Cotte, Eddy, additional, Ouaissi, Mehdi, additional, Bridoux, Valérie, additional, Corbière, Lisa, additional, Heraud, Jeanne, additional, Ortega‐Deballon, Pablo, additional, Abo‐Alhassan, Fawaz, additional, and Hamel, Jean‐Francois, additional
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- 2022
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110. Pressurized Intraperitoneal Aerosol Chemotherapy for Colorectal Peritoneal Metastases
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Jonathan Robin Buggisch, Urs Giger-Pabst, Cedric Demtröder, Can Dogan, Britta Fischer, Clemens B. Tempfer, Thierry Lecomte, Julien Thiery, Günther A. Rezniczek, Nicolas Tabchouri, and Mehdi Ouaissi
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Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Abdominal cavity ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Adverse effect ,Peritoneal Neoplasms ,Aged ,Aerosols ,Aged, 80 and over ,Chemotherapy ,business.industry ,Common Terminology Criteria for Adverse Events ,Odds ratio ,Perioperative ,Middle Aged ,Confidence interval ,Oxaliplatin ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,Colorectal Neoplasms ,business ,medicine.drug - Abstract
The benefit of repetitive PIPAC specifically in CPM patients has yet to be demonstrated in terms of oncological and functional outcomes. The aim of this study was to evaluate the outcome of patients with non-resectable colorectal peritoneal metastases (CPM) treated with pressurized intraperitoneal aerosol chemotherapy (PIPAC). We conducted an analysis of a prospective single-center database of all CPM patients who underwent PIPAC with oxaliplatin 92 mg/m2 body surface (PIPAC-Ox). The outcome criteria were adverse events (Common Terminology Criteria for Adverse Events version 4.0), Peritoneal Regression Grading Score (PRGS), and survival. Overall, 102 patients with a median age of 64 years (33–88) were scheduled for PIPAC-Ox. Access to the abdominal cavity for the first application failed in 22/102 (21.6%) patients. A total of 185 PIPACs were performed, with 26/102 (25.5%), 20/102 (19.6%), 17/102 (16.7%), and 17/102 (16.7%) patients undergoing one, two, three, and four or more PIPACs, respectively. Perioperative overall morbidity/mortality Grade I–V occurred in 14 (7.6%), 29 (15.8%), 6 (3.2%), 1 (0.5%), and 1 (0.5%) patient without significant differences between each cycle. Of 27 patients who underwent three or more PIPACs, 20/102 (19.6%) had major/complete CPM regression (PRGS 1–2). In a multivariate analysis, independent predictive factors for > 12 months’ survival following the first PIPAC-Ox administration were three or more PIPACs (odds ratio [OR] 4.5, 95% confidence interval [CI] 1.35–15.2; p = 0.014) and younger patient age (OR 1.058, 95% CI 1.00–1.12; p = 0.039). Repetitive PIPAC-Ox for CPM patients, alone or combined with perioperative systemic chemotherapy, is feasible. Our data suggest that three or more consecutive PIPAC-Ox cycles for advanced CPM can improve survival.
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- 2021
111. Experimental Model to Test Electrostatic Precipitation Technology in the COVID-19 Era: A Pilot Study
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Alain Le Pape, Michael Stintz, Sébastien Roger, Daniel Göhler, Andreas Rudolph, Jonathan Robin Buggisch, M. Ouaissi, and Urs Giger-Pabst
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Breathing zone ,Infectious Disease Transmission, Patient-to-Professional ,Coronavirus disease 2019 (COVID-19) ,Swine ,Static Electricity ,education ,Indoor bioaerosol ,Air Microbiology ,Electrosurgery ,Pilot Projects ,In Vitro Techniques ,Condensation particle counter ,03 medical and health sciences ,0302 clinical medicine ,Occupational Exposure ,Animals ,Medicine ,CPC, condensation particle counter ,Aerosols ,COVID-19, Coronavirus disease 2019 ,Infection Control ,PNC, particle number concentration in air (1/cm3) ,business.industry ,Experimental model ,COVID-19 ,Original Scientific Article ,Aerosol ,Cholecystectomy, Laparoscopic ,030220 oncology & carcinogenesis ,CAE, continuous aerosol evacuation ,Models, Animal ,Electrostatic precipitation ,USC, ultrasonic cutting ,030211 gastroenterology & hepatology ,Surgery ,business ,EAP, electrostatic aerosol precipitation ,MP HOOK, monopolar electrocautery endo-hook ,LC, laparoscopic cholecystectomy ,Bioaerosol ,Biomedical engineering - Abstract
Background In the COVID-19 crisis, laparoscopic surgery is in focus as a relevant source of bioaerosol release. The efficacy of electrostatic aerosol precipitation (EAP) and continuous aerosol evacuation (CAE) to eliminate bioaerosols during laparoscopic surgery was verified. Study design Ex-vivo laparoscopic cholecystectomies (LCs) were simulated ± EAP or CAE in Pelvitrainer equipped with swine gallbladders. Release of bioaerosols was initiated by performing high-frequency electrosurgery with a monopolar electro hook (MP-HOOK) force at 40 watts (MP-HOOK40) and 60 watts (MP-HOOK60), as well as by ultrasonic cutting (USC). Particle number concentrations (PNC) of arising aerosols were analyzed with a condensation particle counter (CPC). Aerosol samples were taken within the Pelvitrainer close to the source, outside the Pelvitrainer at the working trocar, and in the breathing zone of the surgeon. Results Within the Pelvitrainer, MP-HOOK40 (6.4 × 105 cm-3) and MP-HOOK60 (7.3 × 105 cm-3) showed significantly higher median PNCs compared to USC (4.4 × 105 cm-3) (p = 0.001). EAP led to a significant decrease of the median PNCs in all 3 groups. A high linear correlation with Pearson correlation coefficients of 0.852, 0.825, and 0.759 were observed by comparing MP-HOOK40 (± EAP), MP-HOOK60 (± EAP), and USC (± EAP), respectively. During ex-vivo LC and CAE, significant bioaerosol contaminations of the operating room occurred. Ex-vivo LC with EAP led to a considerable reduction of the bioaerosol concentration. Conclusions EAP was found to be efficient for intraoperative bioaerosol elimination and reducing the risk of bioaerosol exposure for surgical staff., Graphical abstract
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- 2020
112. Advanced colonic cancer with clinically suspected bladder invasion: Outcomes and prognosis from a multicentric study of 117 patients from the FRENCH research group
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Cindy Vuillermet, Hélène Meillat, Gilles Manceau, Ben Creavin, Clarisse Eveno, Stéphane Benoist, Yann Parc, Jérémie H. Lefevre, Sara Arfa, Paul-Noël Dumont, Hortense Boullenois, David Fuks, Mehdi Ouaissi, Leonor Benhaim, Marie Selvy, Jean-Jacques Tuech, Zaher Lakkis, Renato Lupinacci, Antoine Epin, Sophie Deguelte, Guillaume Passot, Bertrand Trilling, Cécile Jarlot-Gas, Muriel Mathonnet, David Moszkowicz, Leila M’Harzi, Laura Beyer Berjot, Service de chirurgie générale et digestive [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Service de Chirurgie Digestive et Endocrinienne [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université - Faculté de médecine Pitié Salpétrière, CHU Pitié-Salpêtrière [AP-HP], St Vincent's University Hospital, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), and AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
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Male ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,Urinary Bladder ,Urology ,030230 surgery ,Cystectomy ,urologic and male genital diseases ,Resection ,03 medical and health sciences ,advanced colon cancer ,0302 clinical medicine ,Colon surgery ,medicine ,Adjuvant therapy ,Humans ,Neoplasm Invasiveness ,Neoadjuvant therapy ,Aged ,Retrospective Studies ,Aged, 80 and over ,bladder invasion ,business.industry ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,3. Good health ,Colonic cancer ,Urinary Bladder Neoplasms ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Female ,Surgery ,local recurrence ,Neoplasm Recurrence, Local ,business ,urinary tract involvement ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,enbloc resection - Abstract
International audience; BackgroundBladder invasion by colon cancer is rare; however, its management is still controversial. Our objective was to report outcomes and identify risk factors for local recurrence in colon cancer with clinically suspected bladder invasion.MethodsWe conducted a retrospective study in 23 centers in France. All patients who underwent colon surgery with bladder resection (2010–2017) were included. Metastatic and recurrent colon cancers were excluded.ResultsOne hundred and seventeen patients (men = 73) were included. Partial cystectomy occurred in 108 patients (92.3%), with a total cystectomy occurring in 9 patients (7.7%). Neoadjuvant treatment was given to 31 patients (26.5%). Major morbidity was 20.5%. R0 resection rates were 87.2%. Histologically confirmed bladder invasion was present in 47%. Thirty-four patients were pN+, while 60 patients (51.3%) received adjuvant chemotherapy. Mean follow-up was 33.8 months. Three-year overall survival and disease-free survival were 82.9% and 59.5%. Rates of local recurrence and distant recurrence were 14.5% and 18.8%, respectively; the local recurrences (11/17; 65%) were in the bladder, while 4 of these patients had a bladder recurrence despite not having histologically confirmed bladder invasion at the index surgery. The rate of bladder recurrence after histologic bladder invasion was 13% (7/55), while the rate of bladder recurrence without primary bladder invasion was 7% (4/62) (P = .343). Neoadjuvant therapy, type of cystectomy, and adjuvant therapy did not influence local recurrence (P > .445 each). R1 bladder resections, when compared with a R0 bladder resections, were associated with an increased rate of local recurrence (63% vs 10%; P < .0001).ConclusionClinically suspected bladder invasion increases local recurrence even in the absence of histologically confirmed bladder invasion. Only complete resections with R0 margins decrease local recurrence. Careful, detailed postoperative surveillance is required, even without pathologic bladder invasion.
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- 2020
113. Elective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans
- Author
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Nepogodiev D., Omar O. M., Glasbey J. C., Li E., Simoes J. F. F., Abbott T. E. F., Ademuyiwa A. O., Biccard B. M., Chaudhry D., Davidson G. H., Di Saverio S., Gallo G., Ghosh D., Harrison E. M., Hutchinson P. J., Kamarajah S. K., Keller D. S., Lawani I., Minaya-Bravo A., Moore R., Morton D. G., Ntirenganya F., Pata F., Pearse R. M., la Medina A. R. -D., Tabiri S., Venn M. L., Omar A. B. O. M., Bhangu A., Siaw-Acheampong K., Adamina M., Agarwal A., Alameer E., Alderson D., Alakaloko F., Alser O., Arnaud A. P., Augestad K. M., Bankhead-Kendall B. K., Barlow E., Benson R. A., Blanco-Colino R., Brar A., Breen K. A., Buarque I. L., Caruana E. J., Chakrabortee S., Cox D., Cunha M. F., Dawson B. E., Desai A., Drake T. D., Edwards J. G., Elhadi M., Evans J. P., Farik S., Fiore M., Fitzgerald J. E., Ford S., Gomes G. M. A., Griffiths E. A., Gujjuri R. R., Halkias C., Heritage E., Isik A., Jenkinson M. D., Jones C. S., Khatri C., Keatley J. M., Kolias A., Lawday S., Lederhuber H., Leventoglu S., LAffler M. W., Martin J., Mashbari H. N., Mazingi D., Mckay S. C., Metallidis S., Mohan H. M., Moszkowicz D., Moug S., Ng-Kamstra J. S., Niquen M., Outani O., Pellino G., Pinkney T. D., Pockney P., Radenkovic D., Roberts K., Roslani A. C., Santos I., Schache A., Schnitzbauer A. A., Stewart G. D., Shaw R., Shu S., Soreide K., Spinelli A., Sundar S., Tiwari A., Townend P., Trout I. M., Tsoulfas G., van Ramshorst G. H., Vidya R., Vimalachandran D., Warren O., Wilkin R. J. W., Wright N., Hoste E., Huyghens L., Jacobs R., Opdenacker G., Poelaert J., Rijckaert D., De Decker K., Foubert L., De Neve N., Biston P., Piagnerelli M., Collin V., den Blauwen N., Clauwaert C., De Crop L., Verbeke A., Derumeaux P., Gardin C., Kindt S., Louage S., Verhamme B., DruwACopyright P., Lahaye I., Rosseel F., Rutsaert R., Vanlinthout L., De Kock M., Forget P., Kahn D., Lois F., Momeni M., Yemnga A. P. B., Jadoul J. -L., Malbrain M., Bosinceanu D., Collard E., Jorens P., Reyntiens D., Smitz C., Vercauteren M., Fagnoul D., Toplice K., OremuA¡ K., BeA¡lic G., Duzel V., Hauptman A., Peremin S., Aribar A., Aupcic M., Brod S., Mirkovic I., Bauer Z. A., Belavic M., BlaA¾anin B., KatuA¡in M. L., Krijan A. B., MiA¡kovic P., Aimic-Korac N., Topic J., Ailic A., Aunic J., Acan I., Adanic M., Ivanov N., Aaric J. P., Tomulic K., Viskovic N., BoA¡njak S., Drenjancevic I. H., Kristek G., Kvolik S., Markic S., Rakipovic A. S., Tot O. K., Fabris L. K., Bacak-Kocman I., Balenovic I., Bandic D., Deutsch P. A. J., Divjak L., Filipovic I. G., GuA¾vinec Z., Krznaric Z., Loncaric Y., MagaA¡ J. V., Mitrovic M., Okic M., Pavlek M., Ramov E., Rezek K., Sekulic A., Tomasevic B., Miric M., TomaA¡evic A., Mahecic T. T., Vrbanovic V., Bobinac M., BoA¾ic A., Debelic D., Frkovic V., Batinica I. M., Baranovic S., Gavranovic A., Kikec M., Maldini B., Maric S., Agnic I., Delic N., Dropulic N., GaA¡pic T. K., Ilic D., Ivancev B., Karanovic N., KuA¡cevic D., Marovic Z., Milic M., NeveA¡canin A., Petkovic T., Smoje M., Brozovic G., Goranovic T., Jelisavac M., Matolic M., Mazul-Sunko B., Oberhofer D., Pavicic A. M., Aakic K., Bozovic M. D., Krecek Z. K., Krobot R., Andabaka T., Bratanic M., Dzepina O., Kraljev M., Aeric J., Aimurina T., Grujic R., Nacevski-Bulaja B., BariA¾on M., Danira V., DraA¾en B., DuA¡anka K., HaluA¾an M. B., JoA¡ko A., Katica R., Labor M., Marinkovic T. G., Mihovilcevic D., Marija B., Srecko M., Drab M., Hudacek K., Krikava I., Stourac P., BrabcovA¡ M., KlozovA¡ R., Vajter J., Vymazal T., Toft P., Blichfeldt L., Hansen B. D., Moller K., Nielsen J. S., Frederiksen J., Andersen J. D., KA¼hne J. P., Leivdal S., Stendell L., Simonsen M., Zoltowski M. K., Ali Z. S., Freundlich M., Pilypaite J., Clausen N. G., Thorup L., Hansen F., Bestle M., Hansen C. S., Afshari A., Bille A. B., Lefort M., Secher E. L., Liboriussen L., Herodes V., HA¤rma E., Marvet K., Pool K., Kallas P., MA¤gi T. -K., SA¼tt J., Vijar K., Visk E., Vinnal M., Ellermaa J., Liibusk L., Hovilehto S., Kirsi A., Mustola S., Tiainen P., Toivonen J., Dabnell S., Kaminski T., Sysimetsa A., Kaukonen M., Silvasti P., Vainio K., Lund V., SjAvall S., Saarinen K., Viitanen M., Ahonen T., AlaspA¤A¤ A., Zittling R., Saarinen A., Moisander A., Wagner B., Laru-Sompa R., Elomaa E., Lavonen L., Nevantaus J., Geier K., Kavasmaa T., Koorits U., Kubjas M., Lauritsalo S., Ottelin L., Palve M., PynnAnen J., RA¤A¤bis I., Saarelainen M., HeikkilA¤ T., Kontula T., LehtimA¤ki M., Liimatainen J., Moilanen-Oikarinen M., Pakarinen M., Palanne R., SeppA¤nen H., Pulkkinen A., VA¤A¤rA¤niemi H., Kajaani, Paananen S., Koskenkari J., SA¤lkiA S., Vakkala M., Koskue T., Loisa P., Laitio R., HautamA¤ki R., Koivisto S. -P., Leon A., Bonnet F., Marret E., Spielvogel C., Papageorgiou C., Szymkiewicz O., Tounou-Akue F., Aubrun F., Bonnet A., Gazon M., Guiraud M., Laurent V., Tachon G., Demars N., Dumenil A. -S., Mercier F. J., Landais A., Mentec H., Bazin M., Futier E., Gonnu S., Petit A., Albaladejo P., Almeras L., Rossi-Blancher A. B. M., Lefrant J. Y., Barthel F., Hallel D., Sbai H., Khalifeh P., Lidzborski L., Jully M., Platon E., Pottecher J., Baumgarten R., Schultz C., ElMiloudi F., Lefebvre J., Waton K., Sprunck A., Steib A., Thibaud A., Thuet V., Kieffer V., Dubois-Vallaud D., Jacob L., Becanne X., Cherfaoui S., Gauzit R., Godier A., Lakhdari M., Samma C. M., Halchini C., Lacroix M., Pinna F., Barbes A., Just B., Mateu P., Benayoun L., Berger P., Granier N., Perrigault P. F., Libert N., De Rudnicki S., Merat S., Bourdet B., FerrACopyright F., Minville V., Piriou V., Rague P., Wallet F., Lebuffe G., Desbordes J., Robin E., Ichai C., Orban J. -C., Gottschalk A., Piontek A., Unterberg M., Hilpert J., Kees M., Triltsch A., Wiegand-LAhnert C., GlAckner C., Hohn A., Rose E., SchrAder S., Wiese O., Awlakpui E., Hoeft A., Scheidemann M., Wittmann M., Ramminger A., Dresden C., de Abreu M. G., Heller A. R., Marx C., Neidel J., Goldmann A., von Heymann C., Laetsch B., Maahs E., Scholz L., Frenzel D., Massarat K., Lenhart F. -P., Reichle F., Rudlof K., Borchers F., Buettner C., Schmutzler M., Lucht A., Wagner J., Wuppertal H. K., Pilge S., Schneider G., Untergehrer G., Bis B., Krassler J., Dittmann J., Haberkorn J., Eberitsch J., Eberitsch K., Nippraschk T., Wepler U., Engelen W. -C., Nau C., Scholler A., SchA¼ttler J., Wintzheimer S., Bloos F., Braune A., Fergen D., Ludewig K., Paxian M., Reinhart K., Graf N., Schwarzkopf K., Berger K., Habicher M., Kasperiunaite R., Savelsberg S., Krep H., Reindl M., Bauer W., Bingold F., Christ S., Friederich P., Kaviani R., Auer P., BonnlA¤nder G., Drescher J., Braun R., Eichenauer T., Kerner J., Bierbaum K., BrA¼nner H., Grond S., Perez-Platz U., Andresen B., Linstedt U., Stegmann N., Erkens U., Kopcke J., Meyer A., Brestrich H., Ernst S., Merkel S., Krieger L., Luers F., Weyland A., Noeldge-Schomburg G., Wasmund C., Bredtmann R. -D., Erler I., Haumann C., MAllemann A., Oehmichen U., Sergejewa O., Lehning B., Czeslick E., Geyer M., Malcharek M., Sablotzki A., Stier M., Feld F., Marx G., Rossaint R., Simon V., Armaganidis A., Kotanidou A., Nanas S., Papastylianou A., Psevdi A., Stathopoulos A., Voulas A., Kanna E., Koutsikou A., Moustaka A., Chovas A., Komnos A., Zafiridis T., Franses J., Lavrentieva A., Koraki E., Katsenos C., Kasianidou M. F., Nasopoulou P., Spyropoulou E., Gousia C., Katsanoulas C., Lathyris D., Kyriazopoulos G., Sfyras D., Tsirogianni A., Kostopanagiotou G., Koulenti D., Lignos M., Matsota P., Christopoulos C., Mouratidou A., Vrettou E., Boufidis S., Moka E., Arnaoutoglou E., Koulouras V., Nakos G., Papathanakos G., Anthopoulos G., Choutas G., Karapanos D., Tzani V., Gkiokas G., Nastos K., Nikolakopoulos F., Dragoumanis C., Nikitidis N., Pneumatikos I., Theodorou V., Zacharouli D., Kandi S., Tasopoulos K., Arvaniti K., Matamis D., Mplougoura E., Petropoulou P., Soumpasis I., Amaniti E., Giannakou-Peftoulidou M., Gkeka E., Soultati I., Kokinou M., Papatheodorou L., Stafylaraki M., Giasnetsova T., Gritsi-Gerogianni N., Kydona C., Kiskira O., Koulentis I., Apsokardos A., Dimitropoulos K., Soldatou O., Nathanail C., Papazotos A., Tsakas P., Clouva-Molyvdas P. -M., Kolotoura A., Sartzi M., Papanikolaou S., Polakis P., Karatzas S., Kyparissi A., Papavasilopoulou T., Koukoubani T., Mastora E., Nyktari V., Malliotakis P., Papaioannou A., Bekos V., Maragkou E., Spring A., Ioakeimidou S. E. A., Noulas N., MolnA¡r Z., CsA¼llAg E., Elekes E., MolnA¡r T., Katona Z., Kremer I., Miko A., Budapest, Csomos A., Galambos Z., Szucs A., Szekeres G., Szabo E., Kranitz K., Simon M., Szigeti J., GaA¡l E., Havas A., Ille A., Miskolc, BrA¡z K., Nagy G., Hafeez P., Hanumanthaiah D., Brohan J., O'Chroinin D., Bailey K., Ramamoorthy K. G., Doyle Y., Freir N., O'Rourke J., Jonson P., Saeed S., Hayes I., Loughrey J., Frohlich S., McCauley N., Ryan D., Fitzpatrick G., Kevin L., Thomas J., Warde B., Woolhead A., Duggan M., Egan C., Crowley S., Lebese S., Bergin A., Westbrook A., Page R., Collins D., McKenny M., Bresciani A., Carmino L., Ghelfi S., Lorenzelli L., Novelli M. T., Pescarmona C., Roasio A., Gatta A., Nastasi M., Sanseverino M., Tinti C., Bianchin A., Tormena M. P., Franco A., Marini F., Di Mauro P., Rapido F., Tommasino C., Bellotti F., Boninsegna D., Castellani G., Sances D., Spano G., Tredici S., Vezzoli D., Fucecchio I., Bacci A., Coppini R., Dell'unto S., Mori E., Stanzani M. R., Tosi M., Collareta M., Forfori F., Franchi M., Mancino G., Battistella M., Baricocchi E., Bona F., Debernardi F., Giacoletto G., Iacobellis A., Massucco P., Moselli N., Muratore A., Palomba G., Sardo E., Suita L., Zocca E., Bucci B., Corte F. D., Piciucco T., Viarengo V., Cantarini E., Giampieri M., Tanfani A., Recchia E., Bignami E., Bruno G., Costagliola R., Gandolfi A., Greco M., Lembo R., Monti G., Nicelli E., Pasculli N., Turi S., Rocca G. D., Baroselli A., Brazzoni M., Buttazzoni M., Buttera S., Centonze C., Serena G., Spagnesi L., Toretti I., Vilardi A., Zearo E., Arpino I., Baraldi S., Guarnerio C., Molene V., Monea M. C., Vaccarisi E., Vicari L., Albante A., Aversano M., Loiacono C., Marandola M., Fusari M., Petrucci N., Galla A., Mascia A., Primieri P., Di Noto A., Gratarola A., Molin A., Pelosi P., Spagnolo L., Spena C., Calligaro P., Marchiotto S., Merlini A., Pedrazzoli E., Perina G., Visentin R., Fumagalli R., Garbagnati A., Manetti B., Snaier C., Somaini M., Farnia A., Nani R., Pierantonio N., Grasso S., Gazzanelli S., Pugliese F., Ruberto F., Bergamini E., Tassinati T., Capuzzo M., Cirillo V., Tufano R., Oggioni R., Parrini V., Brunori E., Capone M., Carbone L., Corradetti F., Elisei D., Fiorentino S., Francesconi M., Gattari D., Gorgoglione M., Iacobone E., Minnucci F., Montironi C., Riccioni G., Tappata G., Zompanti V., Verdenelli P., Cerutti E., Ranieri V. M., Grigorjevs S., Rikmane M., Rozkalne D., Stepanovs J., Suba O., Golubovska I., Kazune S., Miscuk A., Nemme J., Oss P., Sipylaite J., Macas A., Ragaisis V., Kontrimaviciute E., Tomkute G., Boerma E. C., Leeuwarden M. C., Kramer I. F., Poeze M., Maria J., Pelzer G., Nijsten M., Schoorl M., Spanjersberg R., Buhre W., Dieleman S., van Klei W. A., Bouw M., Pickkers P., Schreiner F., Zandvliet R., van den Berg R., De Wit E., Keijzer C., Hollmann M. W., Preckel B., van Acker G. J. D., Dennesen P. J. W., Kuijpers-Visser A. G., Inan T., Gemert A. W. M. M. K. -V., Ponssen H. H., Brouwer T., Koopmans M., van Bommel J., van Duijn D., van der Hoven B., Ormskerk P., Beck O., Schiere S., Reidinga A. C., Venema A., Jammer I., Dokka V., Monsen S. A., Ytrebo L. M., Noursadeghi M., Shahzad A., Boksasp O. D., Roiss C., Strietzel H. F., Berntsen A. G. S., Haugland H., Vingsnes S. O., Axelsson P., Risom Olsen T. C., Katre S., Aakeroey K., Tamowicz B., Bozilow D., Goch R., Grabowski P., Kupisiak J., Mallek M., Szyca R., Kostyrka W., Choma R., Jankowski G., Koscielniak W., Pietraszek P., Szarowar B., FranA§a C., Lacerda A. P., Ormonde L., Rosa R., Pereira I., Vitor P., Bento H. C., Carvalho M. R. L. M., Faria M., Almeida E., Mealha R., Vicente R., Monte R., Rua F., Barros N., Esteves F., Pinheiro C. M. G., Real V., Oliveira V. M., Oliveira M. F., Martins I., Saraiva J. P., AssunA§A£o J. P., BA¡rtolo A., Carvalho A., Correia C., Martins S., Milheiro R., Diaz A., GonA§alves M. I., Ribeiro R., Estilita J., GlAria C., de Almeida J., Barros F., Ramos A., Camara M., Maul E. R., Nobrega J., Langner A., Maia D. F., Afonso O., Faria F., Serra S., Botelho M. M., Ferreira P., MourA£o L., Oliveira A. V., Resende M., Aleman M., Fonseca J., Isidoro M., de Meneses H., PAªgas A., Pereira J., Pereira L., Ramos B., Matos F., Matos R., de Lurdes GonA§alves Castro M., Martins A., Ramos C., de Sousa M., Bento L., Botas C., Lopes V., Mendes R., Blaj M., Damian M., Lupusoru A., Ristescu I., Codreanu M., Diaconescu C., Nistor A., Stelian D. S., Streanga L., Berneanu M., Bordeianu C., Florenta C., Iacob A., Lupu M. N., Mocanu I., Moraru C., Meran C., Nicolae B., Sandu M., Turcanu R., Epure F., Grigore M., Hotaranu C., Popescu N., Baban O., Baciu M., Ciobanu A., Maftei I., Moldovan I., Ungureanu L., Bogdan P., Corneci D., Dinu M., Madalina D., Rely M., Silvius N., Tomescu D., Gabriela D., Dinescu S. A., Calin M., Ionescu D., Margarit S., Vasian H., Albu C., Balasa C., Cadrigati A., Dragulescu D., Gavra L., Hentia C., Macarie C., Manescu M., Nediglea I., Ocica D., Ovidiu B., Papurica M., Plavat C., Popa C., Ramneantu M., Sandesc D., Sandici Z., Sarandan M., Belciu I., Tincu E., Aignatoaie M., Huzuneanu M., Cocu S., Hagau N., Ciubotaru R., Copotoiu S. -M., Copotoiu R., Ioana G., Kovacs J., Leonard A., Szederjesi I., Genoveva V., Mosnegutu S., Djordjevic D., Djordjevic B., Grujic K., Jovanovic D., Obradovic J., Zeba S., Jevdjic J., Miletic M., Zunic F., Bulasevic A., Brko R., Gazibegovic N., Kendrisic M., Vojinovic R., CapkovA¡ J., Firment J., Grochova M., Trenkler S., Griger M., Zahorec R., Bakosova E., Kvasnica M., Saniova B., Sulaj M., Zacharovska A., Simkova A., CAkovA¡ A., Gebhardtova A., HanuljakovA¡ S., Koutun J., MartonovA¡ A., AilincA¡rovA¡ V., Galkova K., Krbila S., Sobona V., Ocenasova M., Novak-Jankovic V., Stecher A., Stivan F., Grynyuk A., Damjanovska M., Kostadinov I., Knezevic M., Malivojevic M., Borovsak Z., Kamenik M., MekiA¡ D., KapA¡ S. O., Aleksic D., Gerjevic B., Kalan K., Ursic T., Artigas A., Garcia A., Lisi A., Perez I., Perez G., Poch N., Vaquer S., Balciscueta G., Barrasa H., Cabanes S., Maynar J., Poveda Y., Rodero A. Q., Vallejo A., Duque P., Garcia-Bunger B., Elvira M. A., Lajara A. M., Palencia M., Ramos R., Fernandez A. S., LeAn J. P. T., LApez J. I., Murillo F. J. Y., Ramirez E. T., Rico P. U., Patricia M., VizcaAno M., Alvarez M. J. B., Real K. P., Serra A. M., Aracil N., Bodega B. M., GarcAa R. F., GarcAa M. A., de la Quintana Gordon B., JodrA¡ A. G., LApez A. D. S., Ros J. J. L., Soto R. A., SepAºlveda I., DAez E. P., FernA¡ndez L. F., Gulina C. S., Arviza L. P., Fernandez L. M., GAmez A. R., MartAnez C. A., RodrAguez A. B. R., Soto C. L., Aldecoa C., Garcia C., Lorenzo M., Pinilla E., Rico J., Ruperez I., Alonso E., Leira F., Maseda D. P. E., Royo C., Villagran J., Candi G. M., Esteva G. E., Folgado R. M., Fornaguera N. J., Montse P. C., Prat A. S., Sintes D., Arteta D. A., Delgado H. G., LApez-Cuervo J. F., LApez M. C., RamArez A., SaldaA+/-a F. J., Aliste P., Anchuelo A. H., Campos A. G., CatalA¡n M., GAmez M. G., Gonzalaez O. G., LApez E. L., Navacerrada I. R., de Quevedo S. A., Serrano M. G., Silvestre F. P. -C., Torrente F. M., Arocas B., Martinez E. P., Soro M., Maroto F., Algarra R. R., Aleixandre I. S., Argente G. R., LleA A. B., Rubio A. V., SA¡nchez J. L. V., ValcA¡rcel I. E., Balust C., Balust J., Borrat X., Carretero M. J., Gracia I., Matute P., Mercadal J., Pujol R., Tena B., Ubre M., Albalad D. D., Alcaide C. M., Caballero J., Cervantes A. C., de Nadal Clanchet M., Estruch N. M., Ferrer M. B., Fornells A. L., Galera E. T., Martinez I. G., MuA+/-oz S. M., Pelavski A., Perez P. T., Posada M. A. G., de Prat I. C., Rello J., Serrano L. G., Sieiro J. M. N., Silva L., Sole M. J. C., SuA+/-ACopyright A. B., Villach I. R., Herreras J. I. G., Poves R., Rafael B. M., Almeida I. M., Collates A. F., BartolomACopyright M. J., Cimadevilla B., GonzA¡lez A. M. G., Llevot J. M. R., de TerA¡n Mira J. C. D., Molina B. G., Pardo S., SA¡nchez C. L., Williams M., Zaldibar E., Corsini L. M., Fraile J. R. R., de la Lastra M., Sacramento M. K., SaA+/-a F. J. L., Alvarez J. T., Bulnes M. L. C., Carrasco V. G., del RocAo MAguez Crespo M., Cubillos D. N., Laza E. L., del Pino Heredia PACopyrightrez M., Seisdedos A. A., Torres B. F., Ampuero M. S., Llano M. C., Mata E., Munoz M., Orts M., Planas A., Ramasco F., Roman C., DurA¡n M. V., del RAo Fernandez S., Otero Y. S., Pineiro S. L., Pardal C. B., Alcantud J. F., Antolinos M. A., Barrios F., Casanova A. C., Castro M. R., Crespo B. I., Felipe U. L., Fuster M. L., GarcAa M. S., Garrote B. H., Gonzalez R. M., Granero M. J. M., de la GuAa C. L., LApez R. C., de Frutos LApez S., Martinez J. J. M., Mostaza A. G., Moreno A. J., Osado I. R., PACopyrightrez M. R., PiA+/-a M. A., Romero C. A., RodrAguez E. R., Salvan J. H., Sampedro M. G., de la Torre P. A., Toro J. P., UnzAºe C. L., Vargas M. J., Bernal D. G., Echevarria M., Iglesias A. U., Loza A., Morillo A. R., Serrano P. D., Sevilla F. C. B., Cacho E., CalderAn R., Dufur M., Marginet C., Monedero P., Yepes M. J., Alvarez L. R., Carballal F. F., CastiA+/-eiras A. P., GarcAa P. D., LApez L. R., Maceiras P. R., Puente M. S. M., Rilo M. T. R., Alonso A. E. T., FernA¡ndez S. R., GarcAa R. O., GarcAa A. P., Puentes R. B., Aguado D. N., Carballo C. L., Fernandez R. F., Presedo A. T., de Rabago R. B. D., Velasco A. R., Capel Y. J., CortACopyrights A. F., GarcAa E. M., Gimeno L. M., Klamburg J., Omedas R. C., NAºA+/-ez M. G., Maristany C. L., Ruiz E. M., Artigas X., CastrillAn S., Espinosa N., Gomez-Caro A. M., Illa S., India I., MartAn-Huerta B., Moral V., Moreno M., FernA¡ndez C. I., GarcAa V. F., HernA¡ndez P. P., Checa A. A. H., Diaz D. S., Noguera M. L., Varela I. P., GonzA¡lez Gallego M. A., GarcAa O. M., Irujo J. J. A., Perrino C. G., Picazo J. R., Timoneda F. L., Arroyo M. M., Blanco I. A., Borja M. M., Burcio S. M., Castro N. M., CerdeiriA+/-a A. P., de la Torre Concostrina M., Cristina M. V., DAaz T. D., Esteruelas J. A., Ingelmo I. I., Insuga P. D., Llamas E. C., Lopez J. J. M., MartAn M. B., MartAn E. E., Mesa E. U., Monterde M. L., Montoiro P. A., MAstoles M. L. G., Olarte E. V., PACopyrightrez A. M., Perez F. D., Romero A. S., Rous D. P., Ruiz N. M., Ruiz J. A. P., Saiz A. R., de la Vega Terol A., Toha A. C., Utrera F. A., Alberdi F., ElAsegui I., GarcAa J., Garde P. M., Mintegui E. I., SA¡ez I. G., Salas E., Zabarte M., Diaz-Boladeras R. -M., Mora-Guevara E., Zamora J. F., Bonet A., Salo L., Salinas U., Zaballos J. M., Alvarez A. A., Garrido C. J., Roa J. R. H., Vidal F. G., Garcia-Egea J., Elson M. Z., Seron-Arbeloa C., Asensio M. A. M., SimeAn R. G., Alameda L. E. M., Angulo G. O., Aranzubia M., Arcas J. J., Arevalo J., Belvert B. Q., Calvo C. P., Cremades M., Crespo P., Cuarental A., Del Olmo M., FernA¡ndez P. T., Vega J. L. F. G. I. G., Herrera E., Llorente M. A. A., Rabes C. M., de Maeyer A. 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Mazul-Sunko B., Oberhofer D., Pavicic A.M., Sakic K., Bozovic M.D., Krecek Z.K., Krobot R., Andabaka T., Bratanic M., Dzepina O., Kraljev M., Seric J., Simurina T., Grujic R., Nacevski-Bulaja B., Barizon M., Danira V., Drazen B., Dusanka K., Haluzan M.B., Josko Z., Katica R., Labor M., Marinkovic T.G., Mihovilcevic D., Marija B., Srecko M., Drab M., Hudacek K., Krikava I., Stourac P., Brabcova M., Klozova R., Vajter J., Vymazal T., Toft P., Blichfeldt L., Hansen B.D., Moller K., Nielsen J.S., Frederiksen J., Andersen J.D., Kuhne J.P., Leivdal S., Stendell L., Simonsen M., Zoltowski M.K., Ali Z.S., Freundlich M., Pilypaite J., Clausen N.G., Thorup L., Hansen F., Bestle M., Hansen C.S., Afshari A., Bille A.B., Lefort M., Secher E.L., Liboriussen L., Herodes V., Harma E., Marvet K., Pool K., Kallas P., Magi T.-K., Sutt J., Vijar K., Visk E., Vinnal M., Ellermaa J., Liibusk L., Hovilehto S., Kirsi A., Mustola S., Tiainen P., Toivonen J., Dabnell S., Kaminski T., Sysimetsa A., Kaukonen M., Silvasti P., Vainio K., Lund V., Sjovall S., Saarinen K., Viitanen M., Ahonen T., Alaspaa A., Zittling R., Saarinen A., Moisander A., Wagner B., Laru-Sompa R., Elomaa E., Lavonen L., Nevantaus J., Geier K., Kavasmaa T., Koorits U., Kubjas M., Lauritsalo S., Ottelin L., Palve M., Pynnonen J., Raabis I., Saarelainen M., Heikkila T., Kontula T., Lehtimaki M., Liimatainen J., Moilanen-Oikarinen M., Pakarinen M., Palanne R., Seppanen H., Pulkkinen A., Vaaraniemi H., Kajaani, Paananen S., Koskenkari J., Salkio S., Vakkala M., Koskue T., Loisa P., Laitio R., Hautamaki R., Koivisto S.-P., Leon A., Bonnet F., Marret E., Spielvogel C., Papageorgiou C., Szymkiewicz O., Tounou-Akue F., Aubrun F., Bonnet A., Gazon M., Guiraud M., Laurent V., Tachon G., Demars N., Dumenil A.-S., Mercier F.J., Landais A., Mentec H., Bazin M., Futier E., Gonnu S., Petit A., Albaladejo P., Almeras L., Rossi-Blancher A.B.M., Lefrant J.Y., Barthel F., Hallel D., Sbai H., Khalifeh P., Lidzborski L., Jully M., Platon E., Pottecher J., Baumgarten R., Schultz C., ElMiloudi F., Lefebvre J., Waton K., Sprunck A., Steib A., Thibaud A., Thuet V., Kieffer V., Dubois-Vallaud D., Jacob L., Becanne X., Cherfaoui S., Gauzit R., Godier A., Lakhdari M., Samma C.M., Halchini C., Lacroix M., Pinna F., Barbes A., Just B., Mateu P., Benayoun L., Berger P., Granier N., Perrigault P.F., Libert N., De Rudnicki S., Merat S., Bourdet B., Ferre F., Minville V., Piriou V., Rague P., Wallet F., Lebuffe G., Desbordes J., Robin E., Ichai C., Orban J.-C., Gottschalk A., Piontek A., Unterberg M., Hilpert J., Kees M., Triltsch A., Wiegand-Lohnert C., Glockner C., Hohn A., Rose E., Schroder S., Wiese O., Awlakpui E., Hoeft A., Scheidemann M., Wittmann M., Ramminger A., Dresden C., de Abreu M.G., Heller A.R., Marx C., Neidel J., Goldmann A., von Heymann C., Laetsch B., Maahs E., Scholz L., Frenzel D., Massarat K., Lenhart F.-P., Reichle F., Rudlof K., Borchers F., Buettner C., Schmutzler M., Lucht A., Wagner J., Wuppertal H.K., Pilge S., Schneider G., Untergehrer G., Bis B., Krassler J., Dittmann J., Haberkorn J., Eberitsch J., Eberitsch K., Nippraschk T., Wepler U., Engelen W.-C., Nau C., Scholler A., Schuttler J., Wintzheimer S., Bloos F., Braune A., Fergen D., Ludewig K., Paxian M., Reinhart K., Graf N., Schwarzkopf K., Berger K., Habicher M., Kasperiunaite R., Savelsberg S., Krep H., Reindl M., Bauer W., Bingold F., Christ S., Friederich P., Kaviani R., Auer P., Bonnlander G., Drescher J., Braun R., Eichenauer T., Kerner J., Bierbaum K., Brunner H., Grond S., Perez-Platz U., Andresen B., Linstedt U., Stegmann N., Erkens U., Kopcke J., Meyer A., Brestrich H., Ernst S., Merkel S., Krieger L., Luers F., Weyland A., Noeldge-Schomburg G., Wasmund C., Bredtmann R.-D., Erler I., Haumann C., Mollemann A., Oehmichen U., Sergejewa O., Lehning B., Czeslick E., Geyer M., Malcharek M., Sablotzki A., Stier M., Feld F., Marx G., Rossaint R., Simon V., Armaganidis A., Kotanidou A., Nanas S., Papastylianou A., Psevdi A., Stathopoulos A., Voulas A., Kanna E., Koutsikou A., Moustaka A., Chovas A., Komnos A., Zafiridis T., Franses J., Lavrentieva A., Koraki E., Katsenos C., Kasianidou M.F., Nasopoulou P., Spyropoulou E., Gousia C., Katsanoulas C., Lathyris D., Kyriazopoulos G., Sfyras D., Tsirogianni A., Kostopanagiotou G., Koulenti D., Lignos M., Matsota P., Christopoulos C., Mouratidou A., Vrettou E., Boufidis S., Moka E., Arnaoutoglou E., Koulouras V., Nakos G., Papathanakos G., Anthopoulos G., Choutas G., Karapanos D., Tzani V., Gkiokas G., Nastos K., Nikolakopoulos F., Dragoumanis C., Nikitidis N., Pneumatikos I., Theodorou V., Zacharouli D., Kandi S., Tasopoulos K., Arvaniti K., Matamis D., Mplougoura E., Petropoulou P., Soumpasis I., Amaniti E., Giannakou-Peftoulidou M., Gkeka E., Soultati I., Kokinou M., Papatheodorou L., Stafylaraki M., Giasnetsova T., Gritsi-Gerogianni N., Kydona C., Kiskira O., Koulentis I., Apsokardos A., Dimitropoulos K., Soldatou O., Nathanail C., Papazotos A., Tsakas P., Clouva-Molyvdas P.-M., Kolotoura A., Sartzi M., Papanikolaou S., Polakis P., Karatzas S., Kyparissi A., Papavasilopoulou T., Koukoubani T., Mastora E., Nyktari V., Malliotakis P., Papaioannou A., Bekos V., Maragkou E., Spring A., Ioakeimidou S.E.A., Noulas N., Molnar Z., Csullog E., Elekes E., Molnar T., Katona Z., Kremer I., Miko A., Budapest, Csomos A., Galambos Z., Szucs A., Szekeres G., Szabo E., Kranitz K., Simon M., Szigeti J., Gaal E., Havas A., Ille A., Miskolc, Braz K., Nagy G., Hafeez P., Hanumanthaiah D., Brohan J., O'Chroinin D., Bailey K., Ramamoorthy K.G., Doyle Y., Freir N., O'Rourke J., Jonson P., Saeed S., Hayes I., Loughrey J., Frohlich S., McCauley N., Ryan D., Fitzpatrick G., Kevin L., Thomas J., Warde B., Woolhead A., Duggan M., Egan C., Crowley S., Lebese S., Bergin A., Westbrook A., Page R., Collins D., McKenny M., Bresciani A., Carmino L., Ghelfi S., Lorenzelli L., Novelli M.T., Pescarmona C., Roasio A., Gatta A., Nastasi M., Sanseverino M., Tinti C., Bianchin 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Saad H., Shanmugam M., Varley S., Wylie K., Cooper L., Makowski A., Misztal B., Moldovan E., Pegg C., Donovan A., Foot J., Large S., Netke B., Armstrong R., Calderwood C., Kwok A., Mohr O., Oyeniyi P., Patnaik L., Post B., Ali S., Arshad H., Baker G., Brenner L., Brincat M., Brunswicker A., Cox H., Cozar O.I., Durst A., Fengas L., Flatt J., Glister G., Narwani V., Photi E., Rankin A., Beaton C., Horn R., Hunt J., Rousseau G., Stancombe L., Absar M., Allsop J., Drinkwater Z., Hodgkiss T., Smith K., Alexander-Sefre F., Campey L., Dudgeon L., Hall K., Hitchcock R., James L., Winstone U., Ahmad N., Bauchmuller K., Harrison J., Jeffery H., Miller D., Pinder A., Pothuneedi S., Rosser J., Sanghera S., Swift D., Bester D., Cavanagh S., Cripps H., Daniel H., Lynch J., Pyke S., Scholefield J., Whitworth H., Ramalingam G., Akerman N., Antill P., Bourner L., Buckley S., Castle G., Charles R., Eggleston C., Foster R., Gill S., Lindley K., Lklouk M., Lowery T., Martin O., Milne D., O'Connor P., 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Solanki S., Spowart E., Stevens A., Waggett H., Yassaee A., Kennedy A., Scott S., Somanath S., Berg A., Hernandez M., Nanda R., Tank G., Wilson N., Wilson D., Al-Soudaine Y., Baldwin M., Cornish J., Davies Z., Davies L., Edwards M., Frewer N., Gallard S., Glasbey J., Harries R., Hopkins L., Kim T., Koompirochana V., Lawson S., Lewis M., Makzal Z., Scourfield S., Ahmad Y., Bates S., Blackwell C., Bryant H., Coulter S., Cruickshank R., Daniel S., Daubeny T., Helen B., Hinxman H., Levett D., Skinner B., Walsgrove J., Dickson J., Constantin K., Karen M., O'Brien P., O'Donohoe L., Sundayi S., Brooke J., Cardy J., Humphreys S., Kessack L., Kubitzek C., Cotterill D., Hodzovic E., Hosdurga G., Miles E., Saunders G., Campbell M., Jemmett K., Raj A., Naik A., Ramamoorthy R., Shah N., Sylvan A., Blyth K., Johnson E., Lo P., Martin T., Plunkett E., Allison J., Carroll C., Craw N., Craw S., Pitt-Kerby T., Rowland-Axe R., Spurdle K., McDonald A., Simon D., Sinha V., Banner-Goodspeed V., Boone M., Campbell K., Lu F., Scannell J., Sobol J., Balajonda N., Clemmons K., Conde C., Funk B., Hopkins T., Olaleye O., Omer O., Pender M., Porto A., Waweru P., Yeh E., Bodansky D., Evans A., Kleopoulos S., Maril R., Mathney E., Sanchez A., Tinuoye E., Bateman B., Eng K., Jiang N., Ladha K., Needleman J., Chen L.-L., Lane R., Robinowitz D., Ghushe N., Irshad M., Takemoto S., Wallace A., Mazzeffi M., Rock P., Wallace K., Zhu X., Chua P., Mattera M., Sharar R., Thilen S., Treggiari M., Morgan A., Sofjan I., Subramaniam K., Avidan M., Maybrier H., Muench M., Wildes T., Elkhogia A.M., Omigbodun A.O., Antwi-Kusi A., Samateh A.L.S., Ndonga A., Basenero A., Mbwele B., Gordon C.S., Youssouf C., Ashebir D.Z., Munlemvo D.M., Zoumenou E., Madzimbamuto F., Ndayisaba G., Sama H.D., Ndasi H., Kluyts H.-L., Tumukunde J., Fawzy M., Mehyaoui R.M., Amanor-Boadu S.D., Rakotoarison S., Esterhuizen T.M., Patel U., Gobin V., Le Manach Y., Ngumi Z., Mehyaoui R., Kanoun H., Chelbi L., Alghazali A., Metali A., 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Ngalala A.M., Kabango R., Kongolo M., Mbayabu M., Namegabe E.S., Bula Bula I.M., Likongo T.B., Pengemale G.N., Bingidimi S.S., Imposo D.H., Matondo P.M., Lelo S.N., Kamanda R.J., Kady N., Ntueba B., Christian M., Badianga E.K., Clc L., Mubeya F.K., Bahta M.T., Kassa S.K., Assefa S.B., Girmaye G.T., Samateh A.L., Janneh L., Sanyang L.N., Nyassi M.T., Grey-Johnson S.V., Villarreal R., Antunez O., Jallow C.S., Roberts C.A., Clegg-Lamptey J.N., Kutor Y.Y., Adu-Aryee N.A., Domoyyeri D.P., Atito-Narh E., Anabah T.W.A., Ndonga A.K.N., Ngumi Z.W.W., Bitta C., Nyawanda H.O., Oduor O.E.O., Okelo O.S., Ogendo S.W.O., Ngari N.B.M., Nyokabi N.N., Chokwe T.M., Gacii V.M., Githae B., Gatheru A.P., Maranga O., Muriithi J.M., Mwangi C.M., Mwiti T.M., Nabulindo S.M., Ndung'u C., Mugambi J., Mtongwe V.M., Kiprop B., Mbadi R., Wambugu P.K., Hersi S., Mutahi S., Aluvale J.S., Gitau S., Kariuki K., Ngatia E., Sitima S., Obadiah S., Mwenda V., Iraya A.M., Waweru E.N., Muturi A., Miima S., Ojujo M., Mossy P., 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A.-J., Mansour I., Rian J.R., Yousef G., Mohamed S., Ahmed E.-Z., Ahmed B., Jamal Z., Abujanah S.A., Amer A.-A., Yousef O., Abozaid W., Elfagieh M.A., Ali A., Zoobei N.Z., Juwid A., Wafa A., Alatresh O.A., Alashhab M., Elzufri A.M., Aldarrat A.D., Matoug F., Alsellabi B., Alkesa T., Addanfour A., Badi H.B., Elfaghi I.E., Salaheddin E., Hamadi L., Hashmi H., Abd-rouf A., Ahmed M., Karar M., Zidan A., Alraheem A.A., Attia A., Yahya A.A., Otman F., Elmadany H., Gerbel G., Saleh M., Eurayet O., Almesmary R., Mostafa H., Abdurazig S., Dahim L., Jermi K., Koraz M.Y.K., Elghallal A.M., Eshwehdi A.A., Elwerfelli A., Elharati F.T., Elrafifi D., Algbali M., Abuhdema F., Elmadani L., Algedar H.A., Shefren I., Abdulrahman A., Najat N.Z., Elkhwildi R.M., Elgelany S., Abduljalil A., Hdud A., Zentuti H.Z., Khetrish S.B., Zeiton A.Z., Altagazi A.A., Almisslati S.H.A., Gandy Y.G., Jasim I., Alghafoud I.A., Hokoma M., Abusnina S.A., Gwila M., Yahya A.I., Mohammed M., Alqawi O.A., Hasan S.H., 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N.T., Freeman Y.B.M., Ehouni A., Jithoo S., Naidoo L., Peter A.M., Belhaj S., Tun M., Kapp P., Bwambale Y.B., Holder H., Kasongo K.J.P., Makhanya V., Morapedi M., Mahomedy N.A., Pillay V., Reddy S.R., Mgoqo N., Mrara B., Nibe Z., Ninise E., Pahlana S.M., Usenbo A.O., Malongwe S.M., Nepogodiev, D., Omar, O. 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H., Kristek, G., Kvolik, S., Markic, S., Rakipovic, A. S., Tot, O. K., Fabris, L. K., Bacak-Kocman, I., Balenovic, I., Bandic, D., Deutsch, P. A. J., Divjak, L., Filipovic, I. G., Gua¾vinec, Z., Krznaric, Z., Loncaric, Y., Magaa¡, J. V., Mitrovic, M., Okic, M., Pavlek, M., Ramov, E., Rezek, K., Sekulic, A., Tomasevic, B., Miric, M., Tomaa¡evic, A., Mahecic, T. T., Vrbanovic, V., Bobinac, M., Boa¾ic, A., Debelic, D., Frkovic, V., Batinica, I. M., Baranovic, S., Gavranovic, A., Kikec, M., Maldini, B., Maric, S., Agnic, I., Delic, N., Dropulic, N., Gaa¡pic, T. K., Ilic, D., Ivancev, B., Karanovic, N., Kua¡cevic, D., Marovic, Z., Milic, M., Nevea¡canin, A., Petkovic, T., Smoje, M., Brozovic, G., Goranovic, T., Jelisavac, M., Matolic, M., Mazul-Sunko, B., Oberhofer, D., Pavicic, A. M., Aakic, K., Bozovic, M. D., Krecek, Z. 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M., Grigorjevs, S., Rikmane, M., Rozkalne, D., Stepanovs, J., Suba, O., Golubovska, I., Kazune, S., Miscuk, A., Nemme, J., Oss, P., Sipylaite, J., Macas, A., Ragaisis, V., Kontrimaviciute, E., Tomkute, G., Boerma, E. C., Leeuwarden, M. C., Kramer, I. F., Poeze, M., Maria, J., Pelzer, G., Nijsten, M., Schoorl, M., Spanjersberg, R., Buhre, W., Dieleman, S., van Klei, W. A., Bouw, M., Pickkers, P., Schreiner, F., Zandvliet, R., van den Berg, R., De Wit, E., Keijzer, C., Hollmann, M. W., Preckel, B., van Acker, G. J. D., Dennesen, P. J. W., Kuijpers-Visser, A. G., Inan, T., Gemert, A. W. M. M. K. -V., Ponssen, H. H., Brouwer, T., Koopmans, M., van Bommel, J., van Duijn, D., van der Hoven, B., Ormskerk, P., Beck, O., Schiere, S., Reidinga, A. C., Venema, A., Jammer, I., Dokka, V., Monsen, S. A., Ytrebo, L. M., Noursadeghi, M., Shahzad, A., Boksasp, O. D., Roiss, C., Strietzel, H. F., Berntsen, A. G. S., Haugland, H., Vingsnes, S. O., Axelsson, P., Risom Olsen, T. C., Katre, S., Aakeroey, K., Tamowicz, B., Bozilow, D., Goch, R., Grabowski, P., Kupisiak, J., Mallek, M., Szyca, R., Kostyrka, W., Choma, R., Jankowski, G., Koscielniak, W., Pietraszek, P., Szarowar, B., Frana§a, C., Lacerda, A. P., Ormonde, L., Rosa, R., Pereira, I., Vitor, P., Bento, H. C., Carvalho, M. R. L. M., Faria, M., Almeida, E., Mealha, R., Vicente, R., Monte, R., Rua, F., Barros, N., Esteves, F., Pinheiro, C. M. G., Real, V., Oliveira, V. M., Oliveira, M. F., Martins, I., Saraiva, J. P., Assuna§a£o, J. P., Ba¡rtolo, A., Carvalho, A., Correia, C., Martins, S., Milheiro, R., Diaz, A., Gona§alves, M. I., Ribeiro, R., Estilita, J., Glaria, C., de Almeida, J., Barros, F., Ramos, A., Camara, M., Maul, E. R., Nobrega, J., Langner, A., Maia, D. F., Afonso, O., Faria, F., Serra, S., Botelho, M. M., Ferreira, P., Moura£o, L., Oliveira, A. 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Z., Juwid, A., Wafa, A., Alatresh, O. A., Alashhab, M., Elzufri, A. M., Aldarrat, A. D., Matoug, F., Alsellabi, B., Alkesa, T., Addanfour, A., Badi, H. B., Elfaghi, I. E., Salaheddin, E., Hamadi, L., Hashmi, H., Abd-rouf, A., Ahmed, M., Karar, M., Zidan, A., Alraheem, A. A., Attia, A., Yahya, A. A., Otman, F., Elmadany, H., Gerbel, G., Saleh, M., Eurayet, O., Almesmary, R., Mostafa, H., Abdurazig, S., Dahim, L., Jermi, K., Koraz, M. Y. K., Elghallal, A. M., Eshwehdi, A. A., Elwerfelli, A., Elharati, F. T., Elrafifi, D., Algbali, M., Abuhdema, F., Elmadani, L., Algedar, H. A., Shefren, I., Abdulrahman, A., Najat, N. Z., Elkhwildi, R. M., Elgelany, S., Abduljalil, A., Hdud, A., Zentuti, H. Z., Khetrish, S. B., Zeiton, A. Z., Altagazi, A. A., Almisslati, S. H. A., Gandy, Y. G., Jasim, I., Alghafoud, I. A., Hokoma, M., Abusnina, S. A., Gwila, M., Yahya, A. I., Mohammed, M., Alqawi, O. A., Hasan, S. H., Rakotoarison, S. R., Albert, F., Hery, A. H., Mamy, R. M., Andriamampionona, A. G. 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R., Masipa, J. N., Matenchi, M. W., Mathe, R. C., Mogale, J. O., Mohlala, M. P., Mongwe, K. N., Morulana, T. G., Motloutsi, S. P., Mphephu, P. E., Muroonga, M. P., Mzezewa, S. Z., Neil, M. C., Neluheni, E. V., Nesengani, D. S., Nesengani, N. T., Netshimboni, L. E., Notoane, I., Omoding, S., Orjiako, O., Perez, N., Pheeha, R. M., Pilusa, K. A., Pochana, M. P., Pupyshev, M., Rambau, M., Ramuntshi, R., Roura, H., Ryabchiy, B. B., Ryndine, V., Sebei, M. P., Moses, V. L., Mungherera, A. R. W., and Pansegrouw, J.
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Adult ,Global Health ,SARS‐CoV‐2 ,Health Services Accessibility ,NO ,cancellation ,Models ,COVID‐19 ,Humans ,Pandemics ,Bayes Theorem ,COVID-19 ,Elective Surgical Procedures ,Health Care Rationing ,Health Policy ,Infection Control ,Models, Statistical ,health care economics and organizations ,Elective Surgical Procedure ,Original Articles ,Statistical ,elective surgery ,Original Article ,human activities ,Human - Abstract
The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.A global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during the 12 weeks of peak disruption. A Bayesian β-regression model was used to estimate 12-week cancellation rates for 190 countries. Elective surgical case-mix data, stratified by specialty and indication (surgery for cancer versus benign disease), were determined. This case mix was applied to country-level surgical volumes. The 12-week cancellation rates were then applied to these figures to calculate the total number of cancelled operations.The best estimate was that 28 404 603 operations would be cancelled or postponed during the peak 12 weeks of disruption due to COVID-19 (2 367 050 operations per week). Most would be operations for benign disease (90·2 per cent, 25 638 922 of 28 404 603). The overall 12-week cancellation rate would be 72·3 per cent. Globally, 81·7 per cent of operations for benign conditions (25 638 922 of 31 378 062), 37·7 per cent of cancer operations (2 324 070 of 6 162 311) and 25·4 per cent of elective caesarean sections (441 611 of 1 735 483) would be cancelled or postponed. If countries increased their normal surgical volume by 20 per cent after the pandemic, it would take a median of 45 weeks to clear the backlog of operations resulting from COVID-19 disruption.A very large number of operations will be cancelled or postponed owing to disruption caused by COVID-19. Governments should mitigate against this major burden on patients by developing recovery plans and implementing strategies to restore surgical activity safely.La pandemia de COVID-19 ha interrumpido los servicios hospitalarios habituales a nivel mundial. En este estudio se calculó el número total de operaciones electivas para adultos que se cancelarían en todo el mundo durante las 12 semanas de interrupción máxima debido a COVID’19. MÉTODOS: Se realizó un estudio global de respuestas de expertos para obtener proyecciones sobre la proporción de cirugía electiva que se cancelaría o pospondría durante las 12 semanas del pico máximo de disrupción. Se usó un modelo bayesiano de regresión beta para estimar las tasas de cancelación durante 12 semanas en 190 países. Se determinaron los datos de la casuística de casos quirúrgicos electivos, estratificados por especialidad e indicación (cáncer versus cirugía benigna). Esta casuística de casos se aplicó a volúmenes quirúrgicos a nivel de país. Las tasas de cancelación de las 12 semanas se aplicaron a estas cifras para calcular el total de operaciones suspendidas.La mejor estimación fue que 28.404.603 operaciones hubieran sido canceladas o pospuestas durante las 12 semanas del pico de disrupción por COVID-19 (2.367.050 operaciones por semana). La mayoría hubieran sido operaciones por enfermedad benigna (90,2%, 25.638.922/28. 404. 603). La tasa de cancelación general en 12 semanas sería del 72,3%. A nivel mundial, el 81,7% (25.638.921/31.378.062) de la cirugía benigna, el 37,7% (2. 324.069/6.162.311) de la cirugía por cáncer y el 25,4% (441.611/1.735.483) de las cesáreas electivas hubieran sido canceladas o pospuestas. Si los países aumentan su volumen quirúrgico normal en un 20% después de la pandemia, se tardaría una mediana de 45 semanas para eliminar la acumulación de operaciones resultantes de la disrupción por COVID’19. CONCLUSIÓN: Se cancelará o pospondrá un número muy grande de operaciones debido a la disrupción causada por COVID-19. Los gobiernos deberían mitigar esta importante carga para los pacientes mediante el desarrollo de planes de recuperación e implementando estrategias para reiniciar de manera segura la actividad quirúrgica.
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- 2020
114. Incidence and prevention of ventral incisional hernia
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Le Huu Nho, R., Mege, D., Ouaïssi, M., Sielezneff, I., and Sastre, B.
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- 2012
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115. Incidence et prophylaxie des éventrations abdominales
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Le Huu Nho, R., Mege, D., Ouaïssi, M., Sielezneff, I., and Sastre, B.
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- 2012
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116. Post-operative adhesions after digestive surgery: Their incidence and prevention: Review of the literature
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Ouaïssi, M., Gaujoux, S., Veyrie, N., Denève, E., Brigand, C., Castel, B., Duron, J.J., Rault, A., Slim, K., and Nocca, D.
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- 2012
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117. Les adhérences postopératoires après chirurgie digestive et leurs préventions : revue de la littérature
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Ouaïssi, M., Gaujoux, S., Veyrie, N., Denève, E., Brigand, C., Castel, B., Duron, J.-J., Rault, A., Slim, K., and Nocca, D.
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- 2012
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118. Quelle est la technique de référence pour la méthode fermée ? Valeur des tests de sécurité
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Ouaïssi, M., Pierre, F., Collinet, P., and Deffieux, X.
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- 2012
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119. Impact of Modern Management Strategies on the Clinical Outcome of Patients With Low Rectal Cancer – A Retrospective, Monocentric Cohort Study
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KARAM, ELIAS, primary, SINDAYIGAYA, REMY, additional, GIGER-PABST, URS, additional, GABRIEL, MICHEL, additional, MICHOT, NICOLAS, additional, COURTOT, LISE, additional, TABCHOURI, NICOLAS, additional, MOUSSATA, DRIFFA, additional, LECOMTE, THIERRY, additional, CHAPET, SOPHIE, additional, CALAIS, GILLES, additional, BOURLIER, PASCAL, additional, SALAMÉ, EPHREM, additional, and OUAISSI, MEHDI, additional
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- 2022
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120. Pectoralis major muscle atrophy is associated with mitochondrial energy wasting in cachectic patients with gastrointestinal cancer
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Dolly, Adeline, primary, Lecomte, Thierry, additional, Tabchouri, Nicolas, additional, Caulet, Morgane, additional, Michot, Nicolas, additional, Anon, Benjamin, additional, Chautard, Romain, additional, Desvignes, Yoann, additional, Ouaissi, Mehdi, additional, Fromont‐Hankard, Gaëlle, additional, Dumas, Jean‐François, additional, and Servais, Stéphane, additional
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- 2022
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121. Adsorption of crystal violet on kaolinite clay: kinetic and equilibrium study using non-linear models
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Boukhemkhem, Ali, primary, Aissa-Ouaissi-Sekkouti, Bamhammed, additional, Bedia, Jorge, additional, Belver, Carolina, additional, and Molina, Carmen B., additional
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- 2022
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122. Simultaneous or Staged Resection for Synchronous Liver Metastasis and Primary Rectal Cancer: A Propensity Score Matching Analysis
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Karam, Elias, primary, Bucur, Petru, additional, Gil, Camille, additional, Sindayigaya, Remy, additional, Tabchouri, Nicolas, additional, Barbier, louise, additional, Pabst-Giger, Urs, additional, Bourlier, Pascal, additional, Lecomte, Thierry, additional, Moussata, MOUSSATA, additional, Chapet, Sophie, additional, Calais, Gilles, additional, ouaissi, Mehdi, additional, and Salame, Ephrem, additional
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- 2022
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123. Long-term Survival After Pancreatic Resection for Renal Cell Carcinoma Metastasis
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Schwarz, L., Sauvanet, A., Regenet, N., Mabrut, J. Y., Gigot, J. F., Housseau, E., Millat, B., Ouaissi, M., Gayet, B., Fuks, D., and Tuech, J. J.
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- 2014
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124. Neoadjuvant Treatment in Upper Rectal Cancer Does Not Improve Oncologic Outcomes But Increases Postoperative Morbidity
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Ephrem Salamé, Gilles Manceau, Arnaud Alves, A. Frontali, Yves Panis, Bruno Heyd, Zaher Lakkis, Y. Eid, Nicolas Tabchouri, Mehdi Ouaissi, Sophie Chapet, Mehdi Karoui, Thierry Lecomte, and Gilles Calais
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Adult ,Male ,Cancer Research ,medicine.medical_specialty ,genetic structures ,Colorectal cancer ,medicine.medical_treatment ,Locally advanced ,Neoadjuvant treatment ,medicine ,Rectal Adenocarcinoma ,Humans ,In patient ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Rectal Neoplasms ,business.industry ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,Combined Modality Therapy ,Total mesorectal excision ,Neoadjuvant Therapy ,Surgery ,Radiation therapy ,Treatment Outcome ,Oncology ,Female ,Morbidity ,business - Abstract
Neoadjuvant chemoradiation/radiation therapy in locally advanced (LA) upper rectal adenocarcinoma management remains unclear. The aim of this study was to compare outcomes between neoadjuvant chemoradiation therapy (CRT) and upfront surgery (US).A total of 127 patients were retrospectively included from 5 centers (79 treated with US and 48 with CRT). CRT and US groups were compared in terms of postoperative complications and long-term oncological and functional results.Total mesorectal excision (TME) was more frequent in CRT (58% vs. 20% in US, p0.001). CRT was associated with more overall and severe postoperative complications (60% vs. 30%, p0.001 and 17% vs. 1%, p=0.002, respectively), and was the only risk factor [OR=18.8 (2.2-160.2), p=0.007]. Five-year overall survival and 5-year recurrence-free survival were similar between CRT and US (96% vs. 91% p=0.256 and 85.4% vs. 85%, p=0.495). The functional results were similar between the two groups.CRT did not improve long-term oncological outcomes in patients with LA upper rectal adenocarcinoma, but increased postoperative complications compared with US.
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- 2020
125. Additional file 2 of Simultaneous or staged resection for synchronous liver metastasis and primary rectal cancer: a propensity score matching analysis
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Karam, Elias, Bucur, Petru, Gil, Camille, Sindayigaya, Remy, Tabchouri, Nicolas, Barbier, Louise, Pabst-Giger, Urs, Bourlier, Pascal, Lecomte, Thierry, Moussata, Driffa, Chapet, Sophie, Calais, Gilles, Ouaissi, Mehdi, and Salamé, Ephrem
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Additional file 2. Table S1. Intraoperative parameters of the 48 patients with rectal cancer and synchronous liver metastases undergoing staged surgery according to their management.
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- 2022
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126. Additional file 1 of Simultaneous or staged resection for synchronous liver metastasis and primary rectal cancer: a propensity score matching analysis
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Karam, Elias, Bucur, Petru, Gil, Camille, Sindayigaya, Remy, Tabchouri, Nicolas, Barbier, Louise, Pabst-Giger, Urs, Bourlier, Pascal, Lecomte, Thierry, Moussata, Driffa, Chapet, Sophie, Calais, Gilles, Ouaissi, Mehdi, and Salamé, Ephrem
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Additional file 1: Figure S1. Comparison flowchart of patients’ adjuvant managements between staged and simultaneous group.
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- 2022
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127. Additional file 3 of Simultaneous or staged resection for synchronous liver metastasis and primary rectal cancer: a propensity score matching analysis
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Karam, Elias, Bucur, Petru, Gil, Camille, Sindayigaya, Remy, Tabchouri, Nicolas, Barbier, Louise, Pabst-Giger, Urs, Bourlier, Pascal, Lecomte, Thierry, Moussata, Driffa, Chapet, Sophie, Calais, Gilles, Ouaissi, Mehdi, and Salamé, Ephrem
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Additional file 3. Table S2. Pathology results of the 48 patients with rectal cancer and synchronous liver metastases undergoing staged surgery according to their management.
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- 2022
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128. Available prediction scores of conversion for laparoscopic rectal cancer surgery seem to be unsuitable for nowadays rectal cancer management
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Hamza Sekkat, Amine Souadka, Lise Courtot, Ali Rafik, Laila Amrani, Amine Benkabbou, Pierre Peyrafort, Urs Giger-Pabst, Elias Karam, Raouf Mohsine, Anass M. Majbar, and Mehdi Ouaissi
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Male ,Logistic Models ,Treatment Outcome ,Rectal Neoplasms ,Humans ,Surgery ,Female ,Laparoscopy ,General Medicine ,Conversion to Open Surgery ,Aged ,Retrospective Studies - Abstract
Introduction This study aimed to externally evaluate the accuracy of four predictive scores for conversion to open surgery after rectal laparoscopic resection. None of the four scores achieved external validation previously. Methods This was a retrospective analysis of two prospectively maintained databases from two academic centers in France and Morocco. All consecutive patients who underwent laparoscopic resection for rectal adenocarcinoma between 2005 and 2020 were included. Logistic regression was used to assess the association between the factors present in the four scores and conversion. The accuracy of each score was assessed using the area under the curve (AUC). Observed and predicted conversion rates were compared for each score using the Chi-square goodness-of-fit test. Results Four hundred patients were included. There were 264 men (66%) with a mean age of 65.95 years (standard deviation 12.2). The median tumor height was 7 cm (quartiles 4–11) and 29% of patients had low rectal tumors. Conversion rate was 21.75%. The accuracy to predict conversion was low with an AUC lower than 0,62 for the four models. The observed conversion rates were significantly different from the predicted rates, except for one score. Conclusions The four models had low accuracy in predicting the conversion to open surgery for laparoscopic rectal resection. There is a need for new well-designed studies, analyzing more specific variables, in a multicentric design to ensure generalizability of the results for daily surgical practice.
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- 2021
129. Long-term evaluation of the impact of delivery modalities on anal continence in women with Crohn's disease
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F. Perrotin, C. Mégier, C. Diguisto, P. Merle, M. Ouaissi, and C. Bourbao-Tournois
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medicine.medical_specialty ,Pregnancy ,Obstetrics ,Vaginal delivery ,business.industry ,Cesarean Section ,medicine.medical_treatment ,Confounding ,Anal Canal ,Context (language use) ,Retrospective cohort study ,General Medicine ,medicine.disease ,Crohn Disease ,Clinical endpoint ,medicine ,Childbirth ,Humans ,Caesarean section ,Female ,business ,Fecal Incontinence ,Retrospective Studies - Abstract
Summary Context Crohn's disease (CD) and sphincter injury during childbirth are two risk factors for anal incontinence (AI). The long-term risk of developing AI in women with CD after childbirth has never been studied. Goal The main objective of the study is to assess the risk of developing severe AI after childbirth in women with CD. Methods A retrospective study was performed in women with CD who gave birth in a French “Level 3” maternity hospital between 2000 and 2015. The primary endpoint was severe AI as defined by a Wexner score ≥ 9 or a St. Mark's score ≥ 9, at least five years after childbirth. The association between delivery route and occurrence of severe AI was assessed by univariate and multivariate analyses. Results Forty-six women were included, 32 of whom were delivered vaginally and 14 by Caesarean section. Thirty-one percent of the women had severe AI according to the Wexner score, and 41% according to the St. Mark's score. Two factors were associated with severe AI: vaginal delivery and the occurrence of an obstetric perineal injury: (crude OR = 8.89, 95% (CI: 1.03–76.57) and crude OR = 4.16, 95% (CI: 1.06–16.27) respectively for AI defined by the Wexner score, and crude OR = 6.8, 95% (CI: 1.30–35.41) and crude OR = 4.3, 95% (CI: 1.23–15.2) for AI defined by the St. Mark's score). After adjusting for confounding factors, only vaginal delivery was associated with severe AI (adjusted OR = 22.86, 95% CI: 1.52–931.28 for a Wexner score ≥ 9 and adjusted OR = 16. 11 (95% CI: 1.43–533.26) for a St Mark score ≥ 9). Conclusion Vaginal birth was associated with the development of severe long-term AI in women with CD.
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- 2021
130. Prognostic value of primary tumor sidedness in patients with non-metastatic IBD related CRC – Is it the exception to the rule?
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Carsten Kamphues, Jeremie H. Lefevre, Jane Wang, Neda Amini, Laurent Beaugerie, Florian Kuehn, Sang Hyoung Park, Nikolaos Andreatos, Johannes C. Lauscher, Diana Enea, Kai S. Lehmann, Nicolas Peru, Benjamin Weixler, Julien Kirchgesner, Claudius E. Degro, Ioannis Pozios, Cornelius J. van Beekum, Sebastian Schölch, Daniela Zambonin, Christian Schineis, Florian N. Loch, Despoina Geka, Maria Theoxari, Bin Wu, Pei-Pei Wang, Efstathios Antoniou, Emmanouil Pikoulis, Driffa Moussata, George Theodoropoulos, Mehdi Ouaissi, Hendrik Seeliger, Yosuke Inaba, Stefano Scaringi, Christoph Reißfelder, Tim O. Vilz, Chen Lin, Suk-Kyun Yang, Katharina Beyer, Bernhard W. Renz, Kazunari Sasaki, Georgios Antonios Margonis, Magali Svrcek, and Martin E. Kreis
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Oncology ,Rectal Neoplasms ,Humans ,Surgery ,Prognosis ,Colorectal Neoplasms ,Inflammatory Bowel Diseases ,Retrospective Studies - Abstract
Although primary tumor sidedness (PTS) has a known prognostic role in sporadic colorectal cancer (CRC), its role in Inflammatory Bowel Disease related CRC (IBD-CRC) is largely unknown. Thus, we aimed to evaluate the prognostic role of PTS in patients with IBD-CRC.All eligible patients with surgically treated, non-metastatic IBD-CRC were retrospectively identified from institutional databases at ten European and Asian academic centers. Long term endpoints included recurrence-free (RFS) and overall survival (OS). Multivariable Cox proportional hazard regression as well as propensity score analyses were performed to evaluate whether PTS was significantly associated with RFS and OS.A total of 213 patients were included in the analysis, of which 32.4% had right-sided (RS) tumors and 67.6% had left-sided (LS) tumors. PTS was not associated with OS and RFS even on univariable analysis (5-year OS for RS vs LS tumors was 68.0% vs 77.3%, respectively, p = 0.31; 5-year RFS for RS vs LS tumors was 62.8% vs 65.4%, respectively, p = 0.51). Similarly, PTS was not associated with OS and RFS on propensity score matched analysis (5-year OS for RS vs LS tumors was 82.9% vs 91.3%, p = 0.79; 5-year RFS for RS vs LS tumors was 85.1% vs 81.5%, p = 0.69). These results were maintained when OS and RFS were calculated in patients with RS vs LS tumors after excluding patients with rectal tumors (5-year OS for RS vs LS tumors was 68.0% vs 77.2%, respectively, p = 0.38; 5-year RFS for RS vs LS tumors was 62.8% vs 59.2%, respectively, p = 0.98).In contrast to sporadic CRC, PTS does not appear to have a prognostic role in IBD-CRC.
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- 2022
131. In Vitro and In Vivo Anticancer Activity of a Novel Nano-sized Formulation Based on Self-assembling Polymers Against Pancreatic Cancer
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Hoskins, Clare, Ouaissi, Mehdi, Lima, Sofia Costa, Cheng, Woei Ping, Loureirio, Inês, Mas, Eric, Lombardo, Dominique, Cordeiro-da-Silva, Anabela, Ouaissi, Ali, and Kong Thoo Lin, Paul
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- 2010
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132. Curcumin and NCLX Inhibitors Share Anti-Tumoral Mechanisms in Microsatellite-Instability-Driven Colorectal Cancer
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Guéguinou, Maxime, primary, Ibrahim, Sajida, additional, Bourgeais, Jérôme, additional, Robert, Alison, additional, Pathak, Trayambak, additional, Zhang, Xuexin, additional, Crottès, David, additional, Dupuy, Jacques, additional, Ternant, David, additional, Monbet, Valérie, additional, Guibon, Roseline, additional, Flores-Romero, Hector, additional, Lefèvre, Antoine, additional, Lerondel, Stéphanie, additional, Le Pape, Alain, additional, Dumas, Jean-François, additional, Frank, Philippe G., additional, Girault, Alban, additional, Chautard, Romain, additional, Guéraud, Françoise, additional, García-Sáez, Ana J., additional, Ouaissi, Mehdi, additional, Emond, Patrick, additional, Sire, Olivier, additional, Hérault, Olivier, additional, Fromont-Hankard, Gaëlle, additional, Vandier, Christophe, additional, Tougeron, David, additional, Trebak, Mohamed, additional, Raoul, William, additional, and Lecomte, Thierry, additional
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- 2022
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133. Prognostic Impact of Upfront Surgery for Locally Advanced Upper Rectal Adenocarcinoma
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MULLER, OLIVIER, primary, SINDAYIGAYA, REMY, additional, CHOMICKI, SANDRA, additional, KARAM, ELIAS, additional, TABCHOURI, NICOLAS, additional, MICHOT, NICOLAS, additional, MOUSSATA, DRIFFA, additional, LECOMTE, THIERRY, additional, CHAPET, SOPHIE, additional, CALAIS, GILLES, additional, GIGER-PABST, URS, additional, SALAME, EPHREM, additional, and OUAISSI, MEHDI, additional
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- 2021
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134. ASO Visual Abstract: Clinical Outcome of Patients Managed with Low-Dose Cisplatin and Doxorubicin delivered as Pressurized Intraperitoneal Aerosol Chemotherapy for Unresectable Peritoneal Metastases of Gastric Cancer
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Sindayigaya, Rémy, primary, Dogan, Can, additional, Demtröder, Cédric Remy, additional, Fischer, Britta, additional, Karam, Elias, additional, Buggisch, Jonathan Robin, additional, Tempfer, Clemens B., additional, Lecomte, Thierry, additional, Ouaissi, Mehdi, additional, and Giger-Pabst, Urs, additional
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- 2021
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135. Is it safe to perform an anastomosis for rectal cancer after prostate cancer? A multicentre study of 126 patients from the GRECCAR group
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Zaher, Lakkis, Alexandre, Doussot, Simone, Manfredelli, Dewi, Vernerey, Hélène, Meillat, Mehdi, Ouaissi, Eddy, Cotte, Jean-Luc, Faucheron, Guillaume, Piessen, Jean-Jacques, Tuech, Jérémie H, Lefevre, Yves, Panis, Laura, Beyer, Antoine, Brouquet, Frédéric, Dumont, Aurélia, Meurisse, Eric, Rullier, and Bruno, Heyd
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Male ,Proctectomy ,Colon ,Rectal Neoplasms ,Anastomosis, Surgical ,Gastroenterology ,Anal Canal ,Humans ,Prostatic Neoplasms ,Anastomotic Leak ,Retrospective Studies - Abstract
To determine the safety of performing an anastomosis after rectal cancer (RC) resection in patients with a previously treated prostate cancer (PC).Patients with a previously treated PC who underwent rectal resection from 2008 to 2018 were retrospectively included. Outcomes were compared between patients who underwent rectal resection with anastomosis (restorative surgery, RS+ group) and those with a definitive stoma (RS- group). In the RS+ group, anastomotic leak (AL) rates were assessed according to the type of reconstruction.A total of 126 patients underwent rectal surgery for mid-low RC after a previous PC treated by radiotherapy (RT) and/or radical prostatectomy. Overall, 80 patients (63%) underwent a RS and 46 patients (37%) underwent rectal surgery with a definitive stoma. There was no statistical difference between the two groups in terms of intraoperative data, except for the type of resection with more multivisceral resection in the RS- group (p 0.01). In the RS+group, a diverting stoma was performed in 74% of cases. No difference between the two groups in terms of overall morbidity was found. In the RS+group (n = 80), 17 patients (21%) experienced AL. Of these, none was observed when delayed coloanal anastomosis was performed (p = 0.16). Long-term permanent stoma in the RS+ group was 16% (n = 13).Restorative surgery after resection for RC in patients with a previous history of RT and/or radical prostatectomy for PC is safe without additional morbidity. In selected patients for restorative surgery, performing delayed coloanal anastomosis may represent a promising option.
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- 2021
136. Simultaneous or staged resection for synchronous liver metastasis and primary rectal cancer: a propensity score matching analysis
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Elias Karam, Petru Bucur, Camille Gil, Remy Sindayigaya, Nicolas Tabchouri, Louise Barbier, Urs Pabst-Giger, Pascal Bourlier, Thierry Lecomte, Driffa Moussata, Sophie Chapet, Gilles Calais, Mehdi Ouaissi, and Ephrem Salamé
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Male ,Rectal Neoplasms ,Liver Neoplasms ,Gastroenterology ,General Medicine ,Middle Aged ,Treatment Outcome ,Hepatectomy ,Humans ,Female ,Prospective Studies ,Colorectal Neoplasms ,Propensity Score ,Retrospective Studies - Abstract
Background Colorectal cancer is the third most common cancer in France and by the time of the diagnosis, 15–25% of patients will suffer from synchronous liver metastases. Surgery associated to neoadjuvant treatment can cure these patients, but few studies focus only on rectal cancer. This study was meant to compare the outcomes of patients who underwent a simultaneous resection to those who underwent a staged resection (rectum first or liver first) in the University Hospital of Tours, France. Methods We assessed retrospectively a prospective maintained data base about the clinical, pathological and survival outcomes of patients who underwent a simultaneous or a staged resection in our center between 2010 and 2018. A propensity score matching was used, considering the initial characteristics of our groups. Results There were 70 patients (55/15 males, female respectively) with median age 60 (54–68) years. After matching 48 (69%) of them underwent a staged approach and 22 (31%) a simultaneous approach were compared. After PSM, there were 22 patients in each group. No differences were found in terms of morbidity (p = 0.210), overall survival (p = 0.517) and disease-free survival (p = 0.691) at 3 years after matching. There were significantly less recurrences in the simultaneous group (50% vs 81.8%, p = 0.026). Conclusions Simultaneous resection of the rectal primary cancer and synchronous liver metastases is safe and feasible with no difference in terms of survival.
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- 2021
137. Development and technical validation of an ultrasound nebulizer to deliver intraperitoneal pressurized aerosols in a rat colon cancer peritoneal metastases model
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Jonathan R. Buggisch, Daniel Göhler, Julien Sobilo, Stéphanie Lerondel, Günther A. Rezniczek, Michael Stintz, Andreas Rudolph, Nicolas Tabchouri, Sébastien Roger, Mehdi Ouaissi, and Urs Giger-Pabst
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Aerosols ,Cancer Research ,Oncology ,Fluorodeoxyglucose F18 ,Nebulizers and Vaporizers ,Colonic Neoplasms ,Genetics ,Animals ,Humans ,Peritoneal Neoplasms ,Rats - Abstract
Background/aim To develop and validate a nebulizer device for anti-cancer research on pressurized intraperitoneal aerosol supply in a preclinical peritoneal metastases (PM) rat model. Material and methods For aerosol generation, an ultrasonic nebulizer (USN) was modified. Aerosol analyses were performed ex-vivo by laser diffraction spectrometry (LDS). Intraperitoneal (IP) 99mtechnetium sodium pertechnetate (99mTc) aerosol distribution and deposition were quantified by in-vivo single photon emission computed tomography (SPECT/CT) and compared to liquid IP instillation of equivalent volume/doses of 99mTc with and without capnoperitoneum. PM was induced by IP injection of HCT116-Luc2 human colon cancer cells in immunosuppressed RNU rats. Tumor growth was monitored by bioluminescence imaging (BLI), 18F-FDG positron emission tomography (PET) and tissues examination at necropsy. Results The USN was able to establish a stable and reproducible capnoperitoneum at a pressure of 8 to 10 mmHg. LDS showed that the USN provides a polydisperse and monomodal aerosol with a volume-weighted diameter of 2.6 μm. At a CO2 flow rate of 2 L/min with an IP residence time of 3.9 s, the highest drug deposition efficiency was found to be 15 wt.-%. In comparison to liquid instillation, nebulization showed the most homogeneous IP spatial drug deposition. Compared to BLI, 18F-FDG-PET was more sensitive to detect smaller PM nodules measuring only 1–2 mm in diameter. BLI, 18F-FDG PET and necropsy analyses showed relevant PM in all animals. Conclusions The USN together with the PM rat model are suitable for robust and species-specific preclinical pharmacological studies regarding intraperitoneal delivery of pressurized aerosolized drugs and cancer research.
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- 2021
138. ONCOGRAM: study protocol for the evaluation of therapeutic response and survival of metastatic colorectal cancer patients treated according to the guidelines of a chemosensitivity assay, the Oncogramme®
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Renaud Martin, Muriel Mathonnet, Christophe Bounaix Morand Du Puch, Stéphanie Giraud, Christophe Lautrette, Mathieu Vanderstraete, Oncogram trial investigators, Abdelkader Taibi, Mehdi Ouaissi, Achille Edem Tchalla, Isabelle Herafa, Niki Christou, and Nicolas Tabchouri
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Oncology ,Medicine (General) ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,ONCOGRAM ,Medicine (miscellaneous) ,Disease ,Oncogramme® ,Study Protocol ,R5-920 ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Multicenter Studies as Topic ,CSRA ,Pharmacology (medical) ,Prospective Studies ,Functional assay ,Chemosensitivity ,Randomized Controlled Trials as Topic ,Chemotherapy ,Rectal Neoplasms ,business.industry ,Cancer ,medicine.disease ,Personalized medicine ,Chemotherapy regimen ,Colonic Neoplasms ,Metastatic ,Biomarker (medicine) ,Colorectal Neoplasms ,business ,Chemosensitivity assay - Abstract
Background Colorectal cancer is a major public concern, being the second deadliest cancer in the world. Whereas survival is high for localized forms, metastatic colorectal cancer has showed poor prognosis, with a 5-year survival barely surpassing 11%. Conventional chemotherapies against this disease proved their efficiency and remain essential in first-line treatment. However, the large number of authorized protocols complexifies treatment decision. In common practice, such decision is made on an empirical basis, by assessing benefits and risks for the patient. In other words, there is currently no efficient means of predicting the efficacy of any chemotherapy protocol for metastatic colorectal cancer. Methods/design The use of a chemosensitivity assay, the Oncogramme®, should help clinicians administer the best chemotherapy regimen to their patients. We hypothesize it would ultimately improve their survival. In this multicentred, prospective trial (ONCOGRAM), eligible patients with metastatic colorectal cancer are randomized to determine whether they will receive an Oncogramme®. For clinicians whose patients benefited from the assay (arm A), results are used as a decision support tool. Patients not undergoing the Oncogramme® procedure are treated according to current practice, without the assistance of the assay (arm B). Primary outcome is 1-year progression-free survival. Secondary outcomes include response rates, as well as 6-month and 1-year survival rates. Discussion This study aims at investigating the clinical utility of the Oncogramme® as a decision support tool for the treatment of patients with metastatic colorectal cancer. If the Oncogramme® positively influenced patient overall survival and/or progression-free survival, it would be of great value for clinicians to implement this assay within the current landscape of personalized medicine tools, which include genomics and biomarker assays. Trial registration ClinicalTrials.gov identifier NCT03133273. Registered on April 28, 2017.
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- 2021
139. Surgical Management of Retrorectal Tumors: A French Multicentric Experience of 270 Consecutives Cases
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Aubert, Mathilde, Mege, Diane, Parc, Yann, Rullier, Eric, Cotte, Eddy, Meurette, Guillaume, Zerbib, Philippe, Trilling, Bertrand, Lelong, Bernard, Sabbagh, Charles, Lakkis, Zaher, Ouaissi, Mehdi, Lebreton, Gil, Rouanet, Philippe, Manceau, Gilles, Tuech, Jean-Jacques, Piessen, Guillaume, Bresler, Laurent, Beyer-Berjot, Laura, Denost, Quentin, Lefevre, Jeremie H., Panis, Yves, Gr, French Res Grp Rectal Canc Surg, Aix-Marseille Université - École de médecine (AMU SMPM MED), Aix-Marseille Université - Faculté des sciences médicales et paramédicales (AMU SMPM), Aix Marseille Université (AMU)-Aix Marseille Université (AMU), Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, Pierre-Bénite, Service de Chirurgie Digestive, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Lille, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Département de chirurgie digestive et de l'urgence, CHU Grenoble-Hôpital Michallon, CHU Pontchaillou [Rennes], CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Service de Chirurgie Digestive [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Institut du Cancer de Montpellier (ICM), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de chirurgie digestive [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de Chirurgie Digestive Hépatobiliaire et Endocrine [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital Nord [CHU - APHM], Sorbonne Université (SU), and Sorbonne Université - Faculté de Médecine (SU FM)
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Adult ,Male ,medicine.medical_specialty ,Postoperative ileus ,Adolescent ,[SDV]Life Sciences [q-bio] ,Young Adult ,medicine ,Humans ,Surgical treatment ,Laparoscopy ,Rectal fistula ,Aged ,Retrospective Studies ,Mean diameter ,Laparotomy ,Surgical approach ,medicine.diagnostic_test ,business.industry ,Rectal Neoplasms ,Incidence ,Significant difference ,Robotics ,Middle Aged ,Combined approach ,Surgery ,Treatment Outcome ,Female ,France ,business - Abstract
International audience; Objective: To report the largest multicentric experience on surgical management of retrorectal tumors (RRT). Background: Literature data on RRT is limited. There is no consensus concerning the best surgical approach for the management of RRT. Methods: Patients operated for RRT in 18 academic French centers were retrospectively included (2000-2019). Results: A total of 270 patients were included. Surgery was performed through abdominal (n = 72, 27%), bottom (n = 190, 70%), or combined approach (n = 8, 3%). Abdominal approach was laparoscopic in 53/72 (74%) and bottom approach was Kraske modified procedures in 169/190 (89%) patients. In laparoscopic abdominal group, tumors were more frequently symptomatic (37/53, 70% vs 88/169, 52%, P = 0.02), larger [mean diameter = 60.5 +/- 24 (range, 13-107) vs 51 +/- 26 (20-105) mm, P = 0.02] and located above S3 vertebra (n = 3/42, 7% vs 0%, P = 0.001) than those from Kraske modified group. Laparoscopy was associated with a higher risk of postoperative ileus (n = 4/53, 7.5% vs 0%, P = 0.002) and rectal fistula (n = 3/53, 6% vs 0%, P=0.01) but less wound abscess (n = 1/53, 2% vs 24/169, 14%, P = 0.02) than Kraske modified procedures. RRT was malignant in 8%. After a mean follow up of 27 +/- 39 (1-221) months, local recurrence was noted in 8% of the patients. After surgery, chronic pain was observed in 17% of the patients without significant difference between the 2 groups (15/74, 20% vs 3/30, 10%; P = 0.3). Conclusions: Both laparoscopic and Kraske modified approaches can be used for surgical treatment of RRT (according to their location and their size), with similar long-term results.
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- 2021
140. The origin and concentration of circulating microparticles differ according to cancer type and evolution: A prospective single-center study
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Mege, Diane, Panicot-Dubois, Laurence, Ouaissi, Mehdi, Robert, Stéphane, Sielezneff, Igor, Sastre, Bernard, Dignat-George, Françoise, and Dubois, Christophe
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- 2016
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141. Voltage-Gated Sodium Channel Na V 1.5 Controls NHE−1−Dependent Invasive Properties in Colon Cancer Cells.
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Lopez-Charcas, Osbaldo, Poisson, Lucile, Benouna, Oumnia, Lemoine, Roxane, Chadet, Stéphanie, Pétereau, Adrien, Lahlou, Widad, Guyétant, Serge, Ouaissi, Mehdi, Pukkanasut, Piyasuda, Dutta, Shilpa, Velu, Sadanandan E., Besson, Pierre, Moussata, Driffa, and Roger, Sébastien
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THERAPEUTIC use of antineoplastic agents ,COLON tumors ,SMALL molecules ,SEQUENCE analysis ,CANCER invasiveness ,GENE expression ,TUMOR classification ,RESEARCH funding ,MEMBRANE proteins ,CELL lines ,EXTRACELLULAR space - Abstract
Simple Summary: Colorectal cancer is a major cause of morbidity and mortality that affects men and women equally. Here, we present the role of voltage-gated sodium channels (Na
V ) and Sodium/hydrogen exchanger type 1 (NHE-1) in conferring invasive capabilities to colorectal cancer cells. We also study how pharmacological inhibition or suppression of their expression by siRNA modifies the aggressive cancer cell phenotype. Our findings suggest that NaV channels and NHE-1 are pertinent molecular targets for cancer therapy. Colorectal cancer (CRC) is the second leading cause of death worldwide, with 0.9 million deaths per year. The metastatic stage of the disease is identified in about 20% of cases at the first diagnosis and is associated with low patient-survival rates. Voltage-gated sodium channels (NaV ) are abnormally overexpressed in several carcinomas including CRC and are strongly associated with the metastatic behavior of cancer cells. Acidification of the extracellular space by Na+ /H+ exchangers (NHE) contributes to extracellular matrix degradation and cell invasiveness. In this study, we assessed the expression levels of pore-forming α-subunits of NaV channels and NHE exchangers in tumor and adjacent non-malignant tissues from colorectal cancer patients, CRC cell lines and primary tumor cells. In all cases, SCN5A (gene encoding for NaV 1.5) was overexpressed and positively correlated with cancer stage and poor survival prognosis for patients. In addition, we identified an anatomical differential expression of SCN5A and SLC9A1 (gene encoding for NHE-1) being particularly relevant for tumors that originated on the sigmoid colon epithelium. The functional activity of NaV 1.5 channels was characterized in CRC cell lines and the primary cells of colon tumors obtained using tumor explant methodologies. Furthermore, we assessed the performance of two new small-molecule NaV 1.5 inhibitors on the reduction of sodium currents, as well as showed that silencing SCN5A and SLC9A1 substantially reduced the 2D invasive capabilities of cancer cells. Thus, our findings show that both NaV 1.5 and NHE-1 represent two promising targetable membrane proteins against the metastatic progression of CRC. [ABSTRACT FROM AUTHOR]- Published
- 2023
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142. StomaCare: quality of life impact after enhanced follow‐up of ostomy patients by a home healthcare nursing service—a multicentre, randomized, controlled trial.
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de Ponthaud, Charles, Roupret, Morgan, Vernerey, Dewi, Audenet, François, Brouquet, Antoine, Cotte, Eddy, Cuvillier, Xavier, Kanso, Frédéric, Meurette, Guillaume, Ledaguenel, Patrick, Maggiori, Léon, Neuzillet, Yann, Ouaissi, Mehdi, Roumiguié, Mathieu, Phé, Véronique, VUONG, Nam‐Son, Parc, Yann, and Lefèvre, Jérémie H.
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OSTOMATES ,NURSING home residents ,NURSING services ,QUALITY of life ,SURGICAL stomas - Abstract
Aim: A stoma exposes patients to several complications which could impair their quality of life (QoL). In the last decade, the market for stoma therapy in France has evolved, with a significant increase in the activities of home health providers, meeting a need for patient follow‐up and companionship. International studies have demonstrated the impact of the stoma therapist (ST) follow‐up on the improvement of an ostomy patient's QoL. However, the impact of home stoma nurse management has not been analysed. In this context we would like to assess the added value on health‐related QoL from the enhanced follow‐up of ostomy patients by STs. Methods: This is a randomized, controlled, open, national and multicentre trial (12 centres) which includes patients with an ostomy who benefit from either standard follow‐up or from an enhanced and personalized follow‐up with, in particular, regular consultations with an ST after discharge. The primary end‐point is the 3‐month QoL score obtained from the Stoma‐QoL questionnaire. The secondary end‐points are satisfaction of the care, comparison of QoL scores (Stoma‐QoL and EuroQuol EQ‐5D) and the economic gains by calculating the consumption of resources between the two arms. There will be a modified intention‐to‐treat analysis with 6‐month follow‐up in both study arms. Discussion: The StomaCare trial will be the first randomized controlled study in France to evaluate the impact on QoL of an enhanced follow‐up at home of ostomy patients by an ST. [ABSTRACT FROM AUTHOR]
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- 2023
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143. Résultats à long terme d’une série monocentrique de PIPAC de patients atteints de carcinose d’origine colorectale
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U. Giger-Pabst, N. Tabchouri, J. Buggisch, C. Demtröder, G. Rezniczek, D. Can, T. Lecomte, M. Ouaissi, and C. Tempfer
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Surgery - Published
- 2022
144. Résultats à long terme d’une prise en charge multidisciplinaire des fistules urétro-rectales après chirurgie urologique
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P. Jeannot, B. Faivre D’Arcier, M. Gabriel, V. Bridoux, F. Bruyere, E. Salame, and M. Ouaissi
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Surgery - Published
- 2022
145. Résultats à long terme d’une série monocentrique de PIPAC de patients atteints de carcinose d’origine gastrique
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G. Giger-Pabst, R. Sindayigaya, J. Buggisch, C. Demtröder, B. Fischer, C. Dogan, T. Lecomte, and M. Ouaissi
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Surgery - Published
- 2022
146. Clinical Outcome for Patients Managed with Low-Dose Cisplatin and Doxorubicin Delivered as Pressurized Intraperitoneal Aerosol Chemotherapy for Unresectable Peritoneal Metastases of Gastric Cancer
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Sindayigaya, Rémy, primary, Dogan, Can, additional, Demtröder, Cédric Remy, additional, Fischer, Britta, additional, Karam, Elias, additional, Buggisch, Jonathan Robin, additional, Tempfer, Clemens B., additional, Lecomte, Thierry, additional, Ouaissi, Mehdi, additional, and Giger-Pabst, Urs, additional
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- 2021
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147. Prise en charge du cancer de l’angle colique gauche en occlusion : résultats d’une étude multicentrique de l’association française de chirurgie
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Labiad, C., primary, Manceau, G., additional, Mège, D., additional, Bridoux, V., additional, Lakkis, Z., additional, Venara, A., additional, Voron, T., additional, Ouaissi, M., additional, and Karoui, M., additional
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- 2021
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148. Résultats à long terme et prise en charge des diverticulites du colon droit dans les pays occidentaux : étude rétrospective multicentrique
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Gilles Manceau, L. Courtot, Guillaume Meurette, Ephrem Salamé, Zaher Lakkis, N. Tabchouri, B. Blanc, A. Mulliri, A. Venara, M. Ouaissi, A. Bouayed, Valérie Bridoux, and Guillaume Piessen
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03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery - Abstract
Resume Objectif La diverticulite du colon droit (DD) est rare en Europe, peu d’etudes s’y sont interessees et sa prise en charge n’est pas standardisee. L’objectif de cette etude etait d’en etudier la presentation clinique (compliquee, non compliquee), la prise en charge en phase aigue et les resultats a long terme dans les pays occidentaux. Methode De 2003 a 2017, 93 patients consecutifs ayant presente une DD ont ete inclus retrospectivement dans 11 centres hospitaliers francais. Resultats La population de l’etude se composait de deux groupes : diverticulites du colon droit non compliquees (DNC) (63,5 %, (n = 59)) et diverticulite du colon droit compliquees (DC) (36,5 %, (n = 34)). Au total, 84,7 % (n = 50/59) des DNC ont eu un traitement conservateur. Au total, 41,2 % (n = 14/34) des DC ont ete operees en urgence (majoritairement par laparotomie) pour peritonite de stade Hinchey III, intolerance clinique ou instabilite hemodynamique. Une totalite de 5,2 % (n = 2/34) des DC ont ete operees a distance (ils presentaient des formes initialement abcedees). Le taux global de complications postoperatoires severes etait faible (8 %). Le taux de recidive etait faible : 7,5 % (n = 7/93) et comparable dans les deux groupes : 6,8 % (n = 4/59) pour les DNC et 8,8 % (n = 3/34) pour les DC. Toutes les recidives se sont produites aux meme localisations pour les DNC. Au total, 42,9 % (n = 3/7) ont ete traitees chirurgicalement par laparoscopie programmee et les autres par un traitement conservateur. Le suivi median etait de 33,2 mois. Conclusion Un traitement conservateur peut etre propose de maniere sure et efficace pour les DNC et pour certains patients selectionnes presentant une DC. La chirurgie doit etre reservee aux patients instables ou aux patients presentant des formes severes de diverticulite compliquee en urgence.
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- 2019
149. Complete Pathological Response Following Radiochemotherapy for Locally Advanced Rectal Cancer: Short and Long-term Outcome
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Lise Courtot, Nicolas Michot, Ephrem Salamé, Othman Iskander, Olivier Muller, Gilles Calais, Mehdi Ouaissi, Aurore Kraemer-Bucur, Alice Artus, Sophie Chapet, P. Bourlier, Urs Pabst-Giger, Nicolas Tabchouri, Thierry Lecomte, Serge Guyétant, Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), University Hospital Münster - Universitaetsklinikum Muenster [Germany] (UKM), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Hôpital Bretonneau, and Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT)
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Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Colorectal cancer ,Biopsy ,[SDV]Life Sciences [q-bio] ,Locally advanced ,Rectum ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Pathological response ,Surgical specimen ,Gastroenterology ,law.invention ,Rectal carcinoma ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Carcinoma ,Humans ,Neoplasm Metastasis ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Rectal Neoplasms ,business.industry ,Chemoradiotherapy ,Colonoscopy ,General Medicine ,Gold standard (test) ,Middle Aged ,medicine.disease ,Combined Modality Therapy ,Neoadjuvant Therapy ,3. Good health ,Treatment Outcome ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Female ,radiochemotherapy ,Tomography, X-Ray Computed ,business ,pathological response - Abstract
International audience; Background/Aim: Preoperative radiochemotherapy (RCT) followed by total mesorectum excision has become the gold standard for locally advanced carcinoma of the low and middle rectum. The aim of the study is to evaluate the short and long-term outcomes of patients in complete pathological response (PR) following this treatment sequence. Patients and Methods: One hundred and thirty patients were retrospectively included between 2005 and 2017 in an expert centre, with 3 groups formed, according to the PR: i) complete PR (absence of tumour cells on the surgical specimen ypT0N0), ii) partial PR (T or N downsizing) and iii) without PR. Results: The complete PR rate was 13.1%. The complete PR group tended to develop less symptomatic fistulas compared to partial PR and without PR groups (5.8% versus 13.5% versus 18.7, respectively; p=0.607). The 5-year disease-free survival was increased for complete-PR patients (93% versus 79% versus 47%, respectively; p=0.0003) without an improvement in overall survival. Conclusion: Complete PR is associated with an improvement in survival without recurrence and without an improvement in the overall survival at 5 years.
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- 2019
150. Nutritional Assistance by Software Improves Surgical Outcomes of Elective Colorectal Surgery
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Aurélie Maignan, Remy Le Huu Nho, Diane Mege, Igor Sielezneff, Cecilia Frasconi, Nicolas Pirro, Regis Hankard, Laurence Boiron, Antonio Iannelli, Jacques di Costanzo, Théophile Guilbaud, Caroline Rossi, Mehdi Ouaissi, and Loundou Anderson
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03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030220 oncology & carcinogenesis ,General surgery ,medicine ,Nutrition support ,030211 gastroenterology & hepatology ,Surgery ,business ,Colorectal surgery - Abstract
Objective The present study analyzes nutrition support in a group of patients undergoing colorectal surgery managed by nutritional requirement software compared to a group of consecutive patients undergoing colorectal surgery with conventional nutrition Materials and Methods A total of 485 patients were treated between January 2000 and January 2013 with colorectal resection. Outcomes (mortality, morbidity according to Clavien classification, length of hospital stay, type of colorectal disease) in a group of patients who received nutrition support through software (SG) were compared to those in a previous series, control group (CG) with conventional nutrition support Results Of the patients, 59.6% were men and the median age of the population was 68.2 years (range, 19–95 years), with no difference between the 2 groups. There were significantly more malnourished patients in the SG group (SG 63.8% versus 45.2% CG; P < 0.0001). The overall mortality was 2.1% lower in the SG group, but without a significant difference (SG 0.7% versus 2.7% CG). There were more severe stage III to IV complications according to Clavien classification in the SG group (SG 10.7 GC versus 17% NS), with significantly greater collections (SG 8% versus 16.9% CG; P = 0.015) and greater anastomotic leaks (SG 4% versus 13.9% CG; P < 0.001). The median hospital stay was lower in the SG group (SG 12 days versus 15 days CG; P = 0.049). Conclusion The proposed software could contribute to optimizing the strategy of nutritional support in hospitalized patients.
- Published
- 2019
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