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101. REAL-WORLD STUDY OF APALUTAMIDE TREATMENT IN PATIENTS WITH METASTATIC HORMONE-SENSITIVE PROSTATE CANCER IN NINE HOSPITALS OF VALENCIAN COMMUNITY.

Author: Lucena, F. J. Rodriguez, Poquet-Jornet, J., Mendoza-Otero, F., Polache-Vengud, J., Díaz-González, M., Bernabeu-Martínez, M. Á., Llinares-Esquerdo, M., Garcia-Garcia, R., Del Busto, N. Garcia, and Garcia-Monsalve, A.
Published: 2024
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102. Rivaroxaban for stroke prevention after embolic stroke of undetermined source

Author: Hart, Robert G, Sharma, Mukul, Mundl, Hardi, Kasner, Scott E, Bangdiwala, Shrikant I, Berkowitz, Scott D, Swaminathan, Balakumar, Lavados, Pablo, Wang, Yongjun, Wang, Yilong, Davalos, Antonio, Shamalov, Nikolay, Mikulik, Robert, Cunha, Luis, Lindgren, Arne, Arauz, Antonio, Lang, Wilfried, Czlonkowska, Anna, Eckstein, Jens, Gagliardi, Rubens J, Amarenco, Pierre, Ameriso, Sebastian F, Tatlisumak, Turgut, Veltkamp, Roland, Hankey, Graeme J, Toni, Danilo, Bereczki, Daniel, Uchiyama, Shinichiro, Ntaios, George, Yoon, Byung-Woo, Brouns, Raf, Endres, Matthias, Muir, Keith W, Bornstein, Natan, Ozturk, Serefnur, O'Donnell, Martin J, De Vries Basson, Matthys M, Pare, Guillaume, Pater, Calin, Kirsch, Bodo, Sheridan, Patrick, Peters, Gary, Weitz, Jeffrey I, Peacock, W Frank, Shoamanesh, Ashkan, Benavente, Oscar R, Joyner, Campbell, Themeles, Ellison, Connolly, Anderson DC, Stuart J., Demets, Dl, Kaste, M, Norrving, B, Wyse, Dg, Alet, M, Allende, G, Beinlich, A, Berrios, W, Bruera, G, Castro, D, Chialvo, L, Claverie, S, Contardo, L, Couto, J, Deganutto, R, Diaz, R, Dossi, D, Esnaola, M, Falco, M, Fernandez Pirrone, P, Ferrari, J, Firstenfeld, A, Galli Giqueauk, E, Gilli, M, Gonzalez, L, Gonzalez Toledo, M, Grecco, M, Halac, B, Hawkes, M, Ioli, P, Jure, L, Klein, F, Lepera, S, Lujan, S, Mackinnon, F, Marroquin, M, Martin, J, Parisi, V, Perez Leguizamon, P, Persi, G, Povedano, P, Povedano, G, Pujol Lereis, V, Radrizzani, L, Reich, E, Repetto, M, Rodriguez Lucci, F, Romano, M, Saredo, G, Schneider, M, Simonsini, C, Sumay, G, Thomson, A, Toledo, W, Torres, C, Vila, A, Abdul Rasheed, N, Anderson, C, Bailey, P, Blacker, D, Carcel, C, Clissold, B, Delcourt, C, Field, D, Gangadharan, S, Ghia, D, Kleinig, T, Leyden, J, Ly, J, Ma, H, Mackey, E, Mishra, S, Moey, A, Musuka, T, Pepper, E, Phan, T, Sabet, A, Saw, J, Singh, B, Tryambake, D, Tu, H, Wijeratne, T, Wong, A, Augustin, S, Esterbauer, M, Garnauf, M, Gasiorek, K, Gasser, S, Gaugg, M, Greisenegger, S, Harrasser, M, Heine, M, Huber, B, Joachim, B, Kapeller, P, Krebs, S, Kreuzpointer, R, Kunzmann, J, Lechner, H, Lohninger, B, Luschin, G, Macher, S, Marko, M, Matosevic, B, Mayr, A, Mismas, A, Mitrovic, N, Mutzenbach, J, Oberndorfer, S, Obmann, S, Raffelsberger, T, Roesler, C, Salletmayr, T, Serles, W, Stadler, K, Tinchon, A, Tolino, M, Verocai, V, Vigl, M, Voglsperger, B, Weber, J, Werner, P, Windt, J, Winkler, A, Wurzinger, H, Zelenka, I, Cras, P, Crols, R, De Keyser, J, De Klippel, N, De Pauw, A, De Smedt, A, Dhollander, I, Hermans, S, Ligot, N, Maqueda, V, Maqueda Maqueda, V, Naeije, G, Seynaeve, L, Soors, P, Van Daele, W, Vanacker, P, Vanderschueren, G, Willems, C, Yperzeele, L, Avelar, W, Bacellar, A, Batista, C, Bazan, R, Braga, G, Cardoso, F, Dagnino, M, Fabio, S, Ferreira Junior, G, Freitas, G, Friedrich, M, Gomes Neto, A, Guarda, S, Katsurayama, M, Machado, M, Martins, S, Meira, F, Minelli, C, Morais, R, Moro, C, Neto, O, Polin, M, Silva, D, Weiss, G, Basile, V, Beaudry, M, Berlingieri, J, Blacquiere, D, Buck, B, Chan, R, Coutts, S, Das, S, Desai, J, Ehrensperger, E, Field, T, Gladstone, D, Hachinski, V, Hassan, A, Hegedus, J, Hill, M, Jin, A, Khaw, A, Mackey, A, Maclean, G, Mandzia, J, Mann, S, Mehdiratta, M, Murphy, C, Ng, K, Oczkowski, W, Penn, A, Perera, K, Perez, Y, Pesant, Y, Phillips, S, Poppe, A, Sahlas, J, Shuaib, A, Spence, D, Sposato, L, Stotts, G, Tamayo, A, Teal, P, Wilson, L, Winder, T, Yegappan, C, Yip, S, Andreu, D, Araya, P, Bustamante, G, Figueroa, C, Gasic, K, Herrero, D, Matamala, G, Munoz, S, Olavarria, V, Pasten, J, Polanco, J, Reyes, P, Roldan, A, Salamanca, P, Silva, P, Toloza, C, Verdugo, M, Cai, K, Che, C, Chen, J, Chen, Z, Chen, T, Chen, H, Chen, X, Chen, B, Chen, G, Chen, L, Chu, F, Cui, L, Dai, C, Ding, N, Ding, J, Du, P, Du, J, Fang, L, Feng, J, Gao, Y, Geng, J, Guan, J, Hao, L, Huang, D, Huang, H, Jin, X, Jing, P, Ke, K, Li, G, Li, M, Li, S, Li, J, Liang, Z, Lin, H, Liu, K, Liu, X, Lu, Z, Ma, C, Pei, H, Qiu, J, Qu, X, Shen, W, Sun, X, Tian, J, Tong, L, Tong, Z, Wang, J, Wang, L, Wang, X, Wang, W, Wang, N, Wang, D, Wang, H, Wen, G, Weng, G, Wu, W, Wu, S, Xiao, B, Xiaopeng, W, Xiong, L, Xiong, Y, Xu, Y, Xu, J, Xu, Z, Yang, L, Yang, Y, Yang, X, Yang, J, Yang, Q, Yang, B, Zhang, C, Zhang, B, Zhang, Y, Zhang, S, Zhang, M, Zhang, X, Zhang, J, Zhao, L, Zhou, L, Bar, M, Barteys, M, Bartolottiova, T, Carek, M, Ferencova, K, Fiksa, J, Gallo, J, Goldemund, D, Hanouskova, L, Herzig, R, Hon, P, Jankovych, J, Jura, R, Kadlcikova, J, Kemlink, D, Kopecky, S, Krajickova, D, Kral, M, Krejci, V, Pavlik, O, Peisker, T, Pernicka, M, Peska, S, Rapantova, P, Reif, M, Rekova, P, Sanak, D, Sebejova, M, Skoda, O, Slonkova, J, Stetkarova, I, Tenora, D, Tumova, R, Vaclavik, D, Vasko, P, Veverka, T, Vitkova, E, Volna, J, Andersen, G, Christensen, H, Christensen, T, Damgaard, D, Iversen, H, Krarup Hansen, C, Kruuse, C, Martinussen, M, Modrau, B, Murtuzova, A, Ovesen, C, Papina, M, Svaneborg, N, Von Weitzel-Mudersbach, P, Curtze, S, Fanta, S, Huhtakangas, J, Keskinarkaus, I, Kivioja, R, Koivu, M, Korpela, J, Larjo, T, Linna, M, Marinkovic, I, Martinez-Majander, N, Nieminen, T, Nikkanen, M, Numminen, H, Ortiz, R, Österlund-Tauriala, E, Roine, R, Roine, S, Ruuskanen, J, Saarinen, J, Shulga, A, Sibolt, G, Tapanainen, A, Tapiola, T, Tiainen, M, Tomppo, L, Tumpula, O, Tuomainen, P, Tynkkynen, J, Vainikka, S, Valpas, J, Virta, J, Ylikallio, E, Ylikotila, P, Accassat, S, Aniculaesei, A, Baronnet, F, Bejot, Y, Bindila, D, Birchenall, J, Blanc-Labarre, C, Bodiguel, E, Bouly, S, Cabrejo, L, Calvet, D, Corlobe, A, Crozier, S, Delpont, B, Deltour, S, Diaconu, M, Domigo, V, Epinat, M, Ferreira, A, Fisselier, M, Garnier, P, Gimenez, L, Gueguen, A, Guidoux, C, Guillon, B, Guiraudg, V, Hervieu-Begue, M, Hobeanu, M, Khoumri, C, Lamy, C, Lauer, V, Le Bouc, R, Lecouturier, K, Leder, S, Leger, A, Macian-Montoro, F, Meseguer, E, Morar-Precup, D, Morvan, T, Morvan, E, Obadia, M, Osseby, G, Philippi, S, Pico, F, Quenardelle, V, Reiner, P, Rigual, R, Rosso, C, Sabben, C, Samson, Y, Sevin, M, Sibon, I, Thouvenot, E, Timsit, S, Touze, E, Turc, G, Vahedi, K, Varvat, J, Wacongne, A, Wolff, V, Yalo, B, Zinchenko, I, Bagelmann, H, Bardutzky, J, Barlinn, J, Bathe-Peters, R, Berrouschot, J, Dietzel, J, Ehrlich, S, Fatar, M, Filipov, A, Fluri, F, Gabriel, M, Geran, R, Gliem, M, Graf, S, Griebe, M, Grosse, G, Haeusler, K, Harmel, P, Held, V, Hellwig, S, Henkner, J, Hieber, M, Hoyer, C, Jander, S, Keilitz, J, Kellner, J, Knecht, S, Koch, M, Koehler, L, Kucken, D, Kusnick, G, Lambeck, J, Lee, J, Leisse, I, Lubke-Detring, S, Machetanz, J, Mensch, A, Meyer, N, Molis, A, Mueller, T, Muhl, C, Nave, A, Radtke, A, Roth, Y, Roukens, R, Schlachetzki, F, Schneider, I, Schuppner, R, Schurig, J, Schwarzbach, C, Seidel, G, Sonntag, N, Steinert, S, Stoll, A, Stumpp, A, Taggeselle, J, Trommer, A, Tuetuencue, S, Wartenberg, K, Weissenborn, K, Wittayer, M, Wolf, M, Wolter, C, Worthmann, H, Wunderlich, S, Zitzmann, A, Anagnostou, E, Brokalaki, C, Hatzitolios, A, Kakaletsis, N, Kanellos, I, Kei, A, Korompoki, E, Koutroubi, A, Liamis, G, Makaritsis, K, Manios, E, Michas, F, Milionis, H, Papadopoulos, G, Papadopoulou, E, Papagiannis, A, Polychronopoulou, E, Sagris, D, Satsoglou, S, Savopoulos, C, Solganov, I, Spengos, K, Stamatelopoulos, K, Terentiou, A, Tountopoulou, A, Vassilopoulou, S, Amjad, A, Balazs, A, Bankuti, Z, Bicsak, T, Borcsik, L, Csanyi, A, Csiba, L, Csontos, K, Csuha, R, Czurko, M, Danku, V, Dioszeghy, P, Faust, K, Fazekas, F, Gerocs, Z, Gottschal, M, Gyuker, N, Hajas, A, Horvath, L, Horvath, M, Iljicsov, A, Jakab, K, Javor, L, Kakuk, I, Karasz, O, Kasa, K, Kasza, J, Kerekgyarto, M, Klivenyi, P, Kovacs, K, Kovacs, T, Kovacs, H, Lajos, B, Lovasz, R, Magyar, T, Matoltsy, A, May, Z, Molnar, S, Monosi, C, Motko, T, Nemeth, R, Nemeth, L, Nikl, J, Olah, L, Orosz, V, Panczel, G, Pentek, S, Prendl, B, Rozsa, C, Rum, G, Sas, K, Sas, A, Semjen, J, Simony, Z, Sipos, I, Szabo, K, Szasz, G, Szegedi, N, Szekely, A, Szilagyi, G, Szoboszlai, K, Szpisjak, L, Toth, G, Uhrinyakova, L, Valikovics, A, Varga, Z, Vass, L, Vastagh, I, Vecsei, L, Zboznovits, D, Coveney, S, Horgan, G, Kelly, P, Murphy, S, Smyth, A, Waters, R, Abu Ahmad, F, Bloch, S, Dorodnicov, E, Hallevi, H, Haratz, S, Horev, A, Kolianov, V, Leker, R, Mahagney, A, Marzelik, O, Rephaeli, G, Tanne, D, Weller, B, Acciarresi, M, Adami, A, Agostoni, E, Alemseged, F, Altavilla, R, Angelocola, S, Anticoli, S, Berardi, V, Bravi, M, Candeloro, E, Cappellari, M, Carletti, M, Caruso, P, Castellini, P, Cavallini, A, Cenciarelli, S, Cerrone, P, Condurso, R, Consoli, D, Danese, A, Della Marca, G, Denaro, M, Di Mascio, M, Diomedi, M, Distefano, M, Frisullo, G, Furlanis, G, Galati, F, Gallina, A, Gallinella, E, Giannandrea, D, Giatsidis, F, Greco, L, Impellizzeri, M, Landolfi, A, Lanfranconi, S, Latte, L, Lembo, G, Longoni, M, Marando, C, Marini, C, Marsili, E, Mastrocola, S, Mazzoli, T, Melis, M, Micheletti, N, Moller, J, Monzani, V, Naccarato, M, Paciaroni, M, Padiglioni, C, Persico, A, Pezzella, F, Pieroni, A, Piras, V, Postorino, P, Pozzerese, C, Profice, P, Ricci, S, Rinaldi, C, Rizzato, B, Rocco, A, Roveri, L, Santalucia, P, Semerano, A, Sicilia, I, Silvestrini, M, Sucapane, P, Tomelleri, G, Tropepi, D, Venti, M, Amino, T, Chin, M, Deguchi, I, Fujigasaki, H, Fukuyama, K, Haraguchi, K, Hasegawa, Y, Hattori, M, Hayashi, T, Hirose, M, Honma, Y, Igarashi, S, Irie, S, Itabashi, R, Ito, Y, Kamata, T, Kaneko, C, Kawanishi, M, Kimura, R, Kitagawa, K, Kobayashi, Y, Kondo, T, Kuwashiro, T, Matsumoto, S, Miyake, H, Nagakane, Y, Nishino, S, Nishiyama, Y, Nogawa, S, Ochiai, J, Ohira, M, Okamoto, Y, Okubo, S, Okuda, S, Ooyama, K, Sakai, N, Suenaga, T, Suzuki, H, Takamatsu, K, Takao, M, Taki, W, Takizawa, S, Tokunaga, K, Toyoda, K, Urui, S, Yamada, T, Yamasaki, M, Yoshida, Y, Yuasa, H, Bae, H, Cha, J, Chang, D, Chung, C, Heo, J, Hong, K, Kim, J, Lee, B, Nah, H, Oh, K, Park, M, Park, J, Rha, J, Sohn, S, Amaya Sanchez, L, Arauz Gongora, A, Cantu Brito, C, Chiquete Anaya, E, Felipe Amaya, P, Fernandez Vera, J, Garcia Lopez, R, Gien Lopez, J, Gongora-Rivera, J, Hernandez, J, Leal Cantu, R, Lopez Garza, N, Medina Pech, C, Mendez, B, Pena Sedna, L, Reyes Morales, S, Ruiz Franco, A, Serrano, F, Tovar, M, Uribe, R, Bak, Z, Baranowska, A, Bilik, M, Blazejewska-Hyzorek, B, Brola, W, Brzoska-Mizgalska, J, Buksinska-Lisik, M, Chorazy, M, Czerska, M, Czuryszkiewicz, M, Dalek, G, Dylewicz, L, Fiszer, U, Fraczek, A, Friedman, A, Fryze, W, Gasecki, D, Gębura, K, Geremek, M, Glabinski, A, Gluszkiewicz, M, Goździk, I, Grzesik, M, Jasek, L, Kaczorowska, B, Kalinowska, K, Kaminska, K, Kapica-Topczewska, K, Karlinski, M, Kobayashi, A, Kosarz-Lanczek, K, Kowalczyk, K, Kowalska, M, Kraska, J, Krzyzanowska, M, Kulakowska, A, Kurkowska-Jastrzebska, I, Lasek-Bal, A, Litwin, T, Morton, M, Myśliwy, W, Nosek, K, Nowak, B, Nowakowska-Śledź, E, Odyniec, A, Oleszek, J, Ozdoba-Rot, J, Palasik, W, Pawelczyk, M, Rozanski, D, Rozniecki, J, Sawicka, M, Sieczkowska, E, Skowron, P, Skowronska, M, Sliwinska, B, Sobolewski, P, Sobota, A, Stoiński, J, Szczuchniak, W, Szczyrba, S, Szewczyk, Z, Szlufik, S, Tarasiuk, J, Tutaj, A, Uchwat, U, Wach-Klink, A, Winska-Tereszkiewicz, A, Wisniewska, A, Włodek, A, Wojnarowska-Arendt, A, Zalewska, J, Zielinska-Turek, J, Ziomek, M, Zwiernik, J, Abreu, P, E Silva A, Amaral, Azevedo, E, Barroso, C, Calejo, M, Campillo, J, Campos Costa, E, Coelho, J, Correia, M, Correia, C, Gregorio, T, Lopes, D, Machado, C, Mendonca, T, Pereira, L, Pidal, A, Pineiro, S, Pinto, A, Ribeiro, J, Rodrigues, M, Salgado, P, Salgado, A, Santo, G, Sargento, J, Varela, R, Abroskina, M, Badalyan, K, Balueva, T, Barulin, A, Bazhenova, O, Belkin, A, Bogdanov, E, Daineko, A, Druzenko, I, Fedin, A, Fidler, M, Gogoleva, E, Golikov, K, Gonysheva, Y, Greshnova, I, Guryanova, N, Gusev, V, Kashaeva, E, Kaygorodtseva, S, Khairutdinova, D, Kholopov, M, Kirpicheva, S, Koltsov, I, Konkov, I, Kurenkova, N, Kurtenkova, N, Kurushina, O, Kustova, M, Lagutenko, M, Lenskaya, L, Lupinogina, L, Lvova, A, Melnikova, E, Meshkova, K, Morozova, E, Mozhejko, E, Nikoforova, M, Obrezan, A, Ondar, V, Pizova, N, Polyakov, A, Popov, D, Prazdnichkova, E, Prokopenko, S, Pudov, E, Salnikov, M, Samoshkina, O, Semushina, D, Shchukin, I, Shepeleva, E, Shmonin, A, Smolkin, A, Soldatov, M, Soloveva, L, Solovyeva, E, Stakhovskaya, L, Tcvetkova, S, Varvyanskaya, N, Voznyuk, I, Zhirnova, O, Ahmed, F, Basson, M, Engelbrecht, J, Hobson, B, Jansen, J, Nel, J, Nell, H, Njovane, X, Pretorius, M, Roos, J, Salig, S, Siebert, M, Amaro, S, Arenillas Lara, J, Arias Rivas, S, Baez Martinez, E, Bas, M, Bashir, S, Bragado, I, Cajaraville, S, Camps, P, Cardona Portela, P, Casado-Naranjo, I, Castellanos, M, Cayuela Caudevilla, N, Chamorro, A, Constantino Silva, A, Cortijo Garcia, E, De La Torre, J, De Torres, R, Diaz Otero, F, Diez-Tejedor, E, Escribano, B, Escudero, I, Fernandez, M, Font, M, Fortea, G, Freijo, M, Fuentes Gimeno, B, Gamero, M, Garcia, J, Garcia Pastor, A, Garcia Sanchez, S, Geniz Clavijo, M, Gil Nunez, A, Giralt, E, Gomez-Choco, M, Gomis, M, Gutiérrez, R, Iglesias Mohedano, A, Lago, A, Lara Lezama, L, Lara Rodriguez, B, Llull, L, Lopez Fernandez, M, Lorenzo, A, Maestre-Moreno, J, Marta Moreno, J, Marti-Fabregas, J, Martínez Sánchez, P, Mauri Cabdevila, G, Mengual Chirifie, J, Molina, C, Molina, J, Moniche, F, Morales, L, Morales, A, Nombela, F, Núñez, F, Pagola, J, Perez, S, Portilla, J, Prats, L, Purroy, F, Quesada Garcia, H, Ramirez Moreno, J, Redondo Robles, L, Renu, A, Riveira Rodriguez, C, Roa, A, Rodriguez Campello, A, Rodriguez Pardo De Donlebun, J, Rodriguez Yanez, M, Rudilosso, S, Ruiz Ares, G, Sànchez Cerón, M, Santamaria Cadavid, M, Sanz Cuesta, B, Serena, J, Silva, Y, Soriano Soriano, C, Tejada Garcia, J, Tejada Meza, H, Tembl, J, Terceno, M, Trillo, S, Urra, X, Usero Ruiz, M, Vazquez, P, Vilar, C, Villanueva Osorio, J, Ximenez-Carrillo, A, Zapata, E, Esbjornsson, M, Karlsson, J, Kremer, C, Kuris, A, Staaf, G, Stiehm, M, Timberg, I, Tossavainen, C, Wester, P, Arnold, M, Baumgartner, P, Beer, J, Bicker, H, Boos, L, Cereda, C, Chaloulos-Iakovidis, P, Christian, L, Engelter, S, Fisch, L, Fischer, U, Frey, S, Frick, M, Hauk, M, Hoffmann, M, Kahles, T, Manno, C, Medlin, F, Mircea, D, Nedeltchev, K, Panos, L, Polymeris, A, Schillinger, N, Stocker, R, Sztajzel, R, Alaydin, H, Batur Caglayan, H, Colakoglu, S, Demirci, N, Duman, T, Eren, F, Gokce, M, Inanc, Y, Nazliel, B, Ongun, G, Ozcekic Demirhan, S, Ozyurt, E, Selcuk, D, Sorgun, M, Tezcan, S, Togay Isikay, C, Tokgoz, O, Ulku Acar, R, Uluduz Ugurlu, D, Abdul-Saheb, M, Ahmad, N, Ali, A, Alwis, L, Balogun, I, Bathula, R, Behnam, Y, Bhandari, M, Bhargavah, M, Black, T, Blank, C, Bruce, D, Burn, M, Canepa, C, Chakrabarti, A, Chandrasena, D, Chembala, J, Cheripelli, B, Clarke, R, Cohen, D, Collas, D, Constantin, C, Dani, K, Del Giudice, A, Dennis, M, Devine, J, Dima, S, Doubal, F, Duodu, Y, Dutta, D, El Ta Wil, S, Elyas, S, Evans, N, Eveson, D, Fotherby, K, France, E, Furnace, J, Grabowski, S, Gunathilagan, G, Gutierrez, R, Guyler, P, Hargroves, D, Harkness, K, Harvey, M, Hayhoe, H, Hicken, L, Hussain, M, Kelly, S, Lam, M, Lindert, R, Louw, S, Luder, R, Macleod, M, Majid, A, Mangion, D, Markova, S, Markus, H, Marsh, R, Mcarthur, K, Menon, N, Metcalf, K, Minhas, J, Minns, M, Mistri, A, Moreton, F, Mpelembue, M, Muddegowda, G, Mudhar, O, Musarrat, K, Myint, M, Natarajan, I, Naylor, D, Ngeh, J, Papavasileiou, V, Perry, R, Piechowski-Jozwiak, B, Pradhan, M, Rani, A, Rashed, K, Robinson, T, Roffe, C, Saksena, R, Sattar, N, Sekaran, L, Selvarajah, J, Shah, S, Sinha, D, Sivakumar, R, Sztriha, L, Walters, D, Webb, T, Werring, D, Whiteley, W, Whiting, R, Abdelhamid, N, Abdul Rahman, D, Amin, H, Androulakis, M, Babikian, V, Baker, M, Barker Trejo, S, Benjamin, A, Birnbaum, L, Burke, J, Chen, S, Clark, W, Coull, B, De Havenon, A, Dearborn, J, Degeorgia, M, Essa, B, Fares, M, Favate, A, Furlan, A, Gebreyohanns, M, Goddeau, R, Green, D, Greer, D, Haralur Sreekantaiah, Y, Hasan, R, Hedna, V, Henninger, N, Holmstedt, C, Ishida, K, Jagolino, A, Johnson, M, Jun-Oconnell, A, Kaur, S, Khanna, A, Kirshner, H, Kittner, S, Kleindorfer, D, Leira, E, Loomis, C, Lord, A, Lowenkopf, T, Lutsep, H, Magadan, A, Majjhoo, A, Maud, A, Mayasi, Y, Mccullough, L, Mckinney, J, Mehta, S, Mehta, D, Mehta, B, Messe, S, Miller, B, Milling, T, Moonis, M, Navaratnam, D, Okpala, M, Patel, N, Pettigrew, L, Phinney, T, Ramos-Estebanez, C, Rasmussen, J, Rodriguez, G, Rybinnik, I, Santiago, P, Sarraj, A, Savitz, S, Sawyer, R, Scandura, T, Schindler, J, Sen, S, Shang, T, Sharrief, A, Sila, C, Simpkins, A, Sundararajan, S, Talahma, M, Tayal, A, Thaler, D, Tirschwell, D, Torres, J, Vora, N, Warnack, W, Waters, M, Wilson, C, Xiong, W, Zweifler, R, Zanferrari, C., St Marys Development Trust, Servicio de Neurologia (SANTIAGO - Neurologie), Universidad del Desarrollo, Department of Neurology (Dep Neuro - BEIJING), Tiantan Hospital, Neurology department, Universidade de Coimbra [Coimbra], Department of Internal Medicine, University Hospital Basel [Basel], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Neurological Sciences, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Department of Neurology, Seoul National University Hospital, Institute of Neurosciences and Psychology [Glasgow], University of Glasgow, Neurology Department, Ichilov Medical Center, CIC Brest, Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital de la Cavale Blanche, Yperzeele, Laetitia, NAVIGATE ESUS Investigators, and Selçuk Üniversitesi
Subjects: Stroke/etiology, Male, [SDV]Life Sciences [q-bio], Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Brain Ischemia, Brain ischemia, 0302 clinical medicine, DESIGN, Rivaroxaban, Hemorrhage/chemically induced, Secondary Prevention, Medicine, Factor Xa Inhibitors/adverse effects, Stroke, Rivaroxaban/adverse effects, ComputingMilieux_MISCELLANEOUS, 11 Medical and Health Sciences, Aspirin, Atrial fibrillation, General Medicine, FORAMEN OVALE CLOSURE, Middle Aged, TRIALS, Intracranial Embolism, SAFETY, Aged, Factor Xa Inhibitors, Female, Hemorrhage, Humans, Platelet Aggregation Inhibitors, Medicine (all), Cardiology, Foramen ovale closure, Platelet aggregation inhibitor, Settore MED/26 - Neurologia, Life Sciences & Biomedicine, medicine.drug, medicine.medical_specialty, Platelet Aggregation Inhibitors/adverse effects, ANTITHROMBOTIC THERAPY, Aspirin/adverse effects, WARFARIN, 03 medical and health sciences, Secondary Prevention/methods, Medicine, General & Internal, Internal medicine, Intracranial Embolism/drug therapy, General & Internal Medicine, NAVIGATE ESUS Investigators, METAANALYSIS, Science & Technology, CRYPTOGENIC STROKE, business.industry, Warfarin, medicine.disease, EFFICACY, ATRIAL-FIBRILLATION, Human medicine, business, Brain Ischemia/prevention & control, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: WOS: 000434263000007, PubMed: 29766772, BACKGROUND Embolic strokes of undetermined source represent 20% of ischemic strokes and are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, may result in a lower risk of recurrent stroke than aspirin. METHODS We compared the efficacy and safety of rivaroxaban (at a daily dose of 15 mg) with aspirin (at a daily dose of 100 mg) for the prevention of recurrent stroke in patients with recent ischemic stroke that was presumed to be from cerebral embolism but without arterial stenosis, lacune, or an identified cardioembolic source. The primary efficacy outcome was the first recurrence of ischemic or hemorrhagic stroke or systemic embolism in a time-to-event analysis; the primary safety outcome was the rate of major bleeding. RESULTS A total of 7213 participants were enrolled at 459 sites; 3609 patients were randomly assigned to receive rivaroxaban and 3604 to receive aspirin. Patients had been followed for a median of 11 months when the trial was terminated early because of a lack of benefit with regard to stroke risk and because of bleeding associated with rivaroxaban. The primary efficacy outcome occurred in 172 patients in the rivaroxaban group (annualized rate, 5.1%) and in 160 in the aspirin group (annualized rate, 4.8%) (hazard ratio, 1.07; 95% confidence interval [CI], 0.87 to 1.33; P=0.52). Recurrent ischemic stroke occurred in 158 patients in the rivaroxaban group (annualized rate, 4.7%) and in 156 in the aspirin group (annualized rate, 4.7%). Major bleeding occurred in 62 patients in the rivaroxaban group (annualized rate, 1.8%) and in 23 in the aspirin group (annualized rate, 0.7%) (hazard ratio, 2.72; 95% CI, 1.68 to 4.39; P, BayerBayer AG; Janssen Research and Development, Supported by Bayer and Janssen Research and Development.
Published: 2018

103. Multiscale Numerical Modelling of Microstructured Reinforced Composites

Author: Otero, F., Oller, S., and Martínez, X.
Subjects: Engineering, Civil, Engineering, Industrial, Engineering, Ocean, Engineering, Marine
Abstract: Most of the existing materials around us can be considered composite materials, since they are composed by several phases or components at certain spatial scale. The physical and chemical properties of composites, as occurs with structures composed by two or more materials, is defined by the response provided by their constituents. Therefore, a good characterization of the composite requires considering the performance of its components. In the last decades, several methods have been proposed with this approach to characterize composite materials, most of them based on multiscale techniques. Nowadays, multiscale homogenization analysis is a popular topic in the simulation of composite materials. This is because the complexity of new composites demands of advanced analysis techniques for their correct characterization, and thanks to the continuous increase of computational capacity. However, the computational cost when multiscale procedures are taken to the non-linear range and are applied to real-size structures is still excessively high. In this context, this monograph presents a comprehensive homogenization formulation for an efficient non-linear multiscale modeling of composite structures. The development of a composite multiscale constitutive model is addressed from two different homogenization approaches. The first one corresponds to a phenomenological homogenization procedure for the non-linear analysis of carbon nanotubes reinforced composites. The second one is a general two-scale homogenization procedure to analyze three-dimensional composite structures. Carbon nanotubes (CNTs) have been regarded as ideal reinforcements for high-performance composites. The formulation developed takes into account explicitly the performance of the interface between the matrix and the CNTs. The load is transferred to the nanotubes through the considered interface. The composite non-linear behavior results from the non-linearities of its constituents, and in case of interface damage, it also becomes non-linear the law defined to couple the interface with the CNTs. The formulation is validated studying the elastic response and non-linear behavior of several composites. In the context of multiscale homogenization, a first-order and an enhanced-first-order formulation is developed. The results obtained for laminate composites using the first-order formulation are compared with other microscopic formulations, showing that the homogenization method is an excellent alternative when microstructural effects must be taken into account. Then, a strategy to conduct non-linear multiscale analysis in an efficient way is proposed. The procedure conserves the dissipated energy through the scales and is mesh independence. The analysis of academic examples is used to show the capacity of the non-linear strategy. Finally, the simulation of an industrial composite component proves the performance and benefits of the non-linear homogenization procedure developed.
Published: 2018

104. Experimental characterization and constitutive modeling of the non-linear stress-strain behavior of unidirectional carbon-epoxy under high strain rate loading

Author: Koerber, H., Kuhn, P., Ploeckl, M., Otero, F., Gerbaud, P.-W., Rolfes, R., Camanho, P.P., and Publica
Abstract: The mechanical response of IM7-8552 carbon epoxy was investigated for transverse tension and transverse tension/in-plane shear loadings at static and dynamic strain rates using transverse tension and off-axis tension specimens. The dynamic tests were carried out on a split-Hopkinson tension bar at axial strain rates from 113 to 300 s−1. With the already available off-axis and transverse compression test data for IM7-8552, a comprehensive data set is available now, which can be used for validation and calibration of numerical models. The measured axial stress-strain response was simulated using a fully 3D transversely isotropic elastic-viscoplastic constitutive model. The constitutive model represents a viscoplastic extension of the transversely-isotropic plasticity model developed by the authors (Vogler et al. in Mech Mater 59:50-64, 2013). An invariant based failure criterion is added to the model to be able to predict the strength for a given orientation and strain rate accurately. The strain rate dependency of the elastic and ultimate strength properties is introduced in the model through scaling functions. A good correlation between the measured and numerically predicted stress-strain response and failure of the specimens was achieved for all specimen types and both strain rate regimes.
Published: 2018

105. A giant exoplanet orbiting a very-low-mass star challenges planet formation models

Author: Morales, J. C., primary, Mustill, A. J., additional, Ribas, I., additional, Davies, M. B., additional, Reiners, A., additional, Bauer, F. F., additional, Kossakowski, D., additional, Herrero, E., additional, Rodríguez, E., additional, López-González, M. J., additional, Rodríguez-López, C., additional, Béjar, V. J. S., additional, González-Cuesta, L., additional, Luque, R., additional, Pallé, E., additional, Perger, M., additional, Baroch, D., additional, Johansen, A., additional, Klahr, H., additional, Mordasini, C., additional, Anglada-Escudé, G., additional, Caballero, J. A., additional, Cortés-Contreras, M., additional, Dreizler, S., additional, Lafarga, M., additional, Nagel, E., additional, Passegger, V. M., additional, Reffert, S., additional, Rosich, A., additional, Schweitzer, A., additional, Tal-Or, L., additional, Trifonov, T., additional, Zechmeister, M., additional, Quirrenbach, A., additional, Amado, P. J., additional, Guenther, E. W., additional, Hagen, H.-J., additional, Henning, T., additional, Jeffers, S. V., additional, Kaminski, A., additional, Kürster, M., additional, Montes, D., additional, Seifert, W., additional, Abellán, F. J., additional, Abril, M., additional, Aceituno, J., additional, Aceituno, F. J., additional, Alonso-Floriano, F. J., additional, Ammler-von Eiff, M., additional, Antona, R., additional, Arroyo-Torres, B., additional, Azzaro, M., additional, Barrado, D., additional, Becerril-Jarque, S., additional, Benítez, D., additional, Berdiñas, Z. M., additional, Bergond, G., additional, Brinkmöller, M., additional, del Burgo, C., additional, Burn, R., additional, Calvo-Ortega, R., additional, Cano, J., additional, Cárdenas, M. C., additional, Guillén, C. Cardona, additional, Carro, J., additional, Casal, E., additional, Casanova, V., additional, Casasayas-Barris, N., additional, Chaturvedi, P., additional, Cifuentes, C., additional, Claret, A., additional, Colomé, J., additional, Czesla, S., additional, Díez-Alonso, E., additional, Dorda, R., additional, Emsenhuber, A., additional, Fernández, M., additional, Fernández-Martín, A., additional, Ferro, I. M., additional, Fuhrmeister, B., additional, Galadí-Enríquez, D., additional, Cava, I. Gallardo, additional, Vargas, M. L. García, additional, Garcia-Piquer, A., additional, Gesa, L., additional, González-Álvarez, E., additional, Hernández, J. I. González, additional, González-Peinado, R., additional, Guàrdia, J., additional, Guijarro, A., additional, de Guindos, E., additional, Hatzes, A. P., additional, Hauschildt, P. H., additional, Hedrosa, R. P., additional, Hermelo, I., additional, Arabi, R. Hernández, additional, Otero, F. Hernández, additional, Hintz, D., additional, Holgado, G., additional, Huber, A., additional, Huke, P., additional, Johnson, E. N., additional, de Juan, E., additional, Kehr, M., additional, Kemmer, J., additional, Kim, M., additional, Klüter, J., additional, Klutsch, A., additional, Labarga, F., additional, Labiche, N., additional, Lalitha, S., additional, Lampón, M., additional, Lara, L. M., additional, Launhardt, R., additional, Lázaro, F. J., additional, Lizon, J.-L., additional, Llamas, M., additional, Lodieu, N., additional, López del Fresno, M., additional, Salas, J. F. López, additional, López-Santiago, J., additional, Madinabeitia, H. Magán, additional, Mall, U., additional, Mancini, L., additional, Mandel, H., additional, Marfil, E., additional, Molina, J. A. Marín, additional, Martín, E. L., additional, Martín-Fernández, P., additional, Martín-Ruiz, S., additional, Martínez-Rodríguez, H., additional, Marvin, C. J., additional, Mirabet, E., additional, Moya, A., additional, Naranjo, V., additional, Nelson, R. P., additional, Nortmann, L., additional, Nowak, G., additional, Ofir, A., additional, Pascual, J., additional, Pavlov, A., additional, Pedraz, S., additional, Medialdea, D. Pérez, additional, Pérez-Calpena, A., additional, Perryman, M. A. C., additional, Rabaza, O., additional, Ballesta, A. Ramón, additional, Rebolo, R., additional, Redondo, P., additional, Rix, H.-W., additional, Rodler, F., additional, Trinidad, A. Rodríguez, additional, Sabotta, S., additional, Sadegi, S., additional, Salz, M., additional, Sánchez-Blanco, E., additional, Carrasco, M. A. Sánchez, additional, Sánchez-López, A., additional, Sanz-Forcada, J., additional, Sarkis, P., additional, Sarmiento, L. F., additional, Schäfer, S., additional, Schlecker, M., additional, Schmitt, J. H. M. M., additional, Schöfer, P., additional, Solano, E., additional, Sota, A., additional, Stahl, O., additional, Stock, S., additional, Stuber, T., additional, Stürmer, J., additional, Suárez, J. C., additional, Tabernero, H. M., additional, Tulloch, S. M., additional, Veredas, G., additional, Vico-Linares, J. I., additional, Vilardell, F., additional, Wagner, K., additional, Winkler, J., additional, Wolthoff, V., additional, Yan, F., additional, and Osorio, M. R. Zapatero, additional
Published: 2019
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106. The CARMENES search for exoplanets around M dwarfs

Author: Zechmeister, M., primary, Dreizler, S., additional, Ribas, I., additional, Reiners, A., additional, Caballero, J. A., additional, Bauer, F. F., additional, Béjar, V. J. S., additional, González-Cuesta, L., additional, Herrero, E., additional, Lalitha, S., additional, López-González, M. J., additional, Luque, R., additional, Morales, J. C., additional, Pallé, E., additional, Rodríguez, E., additional, Rodríguez López, C., additional, Tal-Or, L., additional, Anglada-Escudé, G., additional, Quirrenbach, A., additional, Amado, P. J., additional, Abril, M., additional, Aceituno, F. J., additional, Aceituno, J., additional, Alonso-Floriano, F. J., additional, Ammler-von Eiff, M., additional, Antona Jiménez, R., additional, Anwand-Heerwart, H., additional, Arroyo-Torres, B., additional, Azzaro, M., additional, Baroch, D., additional, Barrado, D., additional, Becerril, S., additional, Benítez, D., additional, Berdiñas, Z. M., additional, Bergond, G., additional, Bluhm, P., additional, Brinkmöller, M., additional, del Burgo, C., additional, Calvo Ortega, R., additional, Cano, J., additional, Cardona Guillén, C., additional, Carro, J., additional, Cárdenas Vázquez, M. C., additional, Casal, E., additional, Casasayas-Barris, N., additional, Casanova, V., additional, Chaturvedi, P., additional, Cifuentes, C., additional, Claret, A., additional, Colomé, J., additional, Cortés-Contreras, M., additional, Czesla, S., additional, Díez-Alonso, E., additional, Dorda, R., additional, Fernández, M., additional, Fernández-Martín, A., additional, Fuhrmeister, B., additional, Fukui, A., additional, Galadí-Enríquez, D., additional, Gallardo Cava, I., additional, Garcia de la Fuente, J., additional, Garcia-Piquer, A., additional, García Vargas, M. L., additional, Gesa, L., additional, Góngora Rueda, J., additional, González-Álvarez, E., additional, González Hernández, J. I., additional, González-Peinado, R., additional, Grözinger, U., additional, Guàrdia, J., additional, Guijarro, A., additional, de Guindos, E., additional, Hatzes, A. P., additional, Hauschildt, P. H., additional, Hedrosa, R. P., additional, Helmling, J., additional, Henning, T., additional, Hermelo, I., additional, Hernández Arabi, R., additional, Hernández Castaño, L., additional, Hernández Otero, F., additional, Hintz, D., additional, Huke, P., additional, Huber, A., additional, Jeffers, S. V., additional, Johnson, E. N., additional, de Juan, E., additional, Kaminski, A., additional, Kemmer, J., additional, Kim, M., additional, Klahr, H., additional, Klein, R., additional, Klüter, J., additional, Klutsch, A., additional, Kossakowski, D., additional, Kürster, M., additional, Labarga, F., additional, Lafarga, M., additional, Llamas, M., additional, Lampón, M., additional, Lara, L. M., additional, Launhardt, R., additional, Lázaro, F. J., additional, Lodieu, N., additional, López del Fresno, M., additional, López-Puertas, M., additional, López Salas, J. F., additional, López-Santiago, J., additional, Magán Madinabeitia, H., additional, Mall, U., additional, Mancini, L., additional, Mandel, H., additional, Marfil, E., additional, Marín Molina, J. A., additional, Maroto Fernández, D., additional, Martín, E. L., additional, Martín-Fernández, P., additional, Martín-Ruiz, S., additional, Marvin, C. J., additional, Mirabet, E., additional, Montañés-Rodríguez, P., additional, Montes, D., additional, Moreno-Raya, M. E., additional, Nagel, E., additional, Naranjo, V., additional, Narita, N., additional, Nortmann, L., additional, Nowak, G., additional, Ofir, A., additional, Oshagh, M., additional, Panduro, J., additional, Parviainen, H., additional, Pascual, J., additional, Passegger, V. M., additional, Pavlov, A., additional, Pedraz, S., additional, Pérez-Calpena, A., additional, Pérez Medialdea, D., additional, Perger, M., additional, Perryman, M. A. C., additional, Rabaza, O., additional, Ramón Ballesta, A., additional, Rebolo, R., additional, Redondo, P., additional, Reffert, S., additional, Reinhardt, S., additional, Rhode, P., additional, Rix, H.-W., additional, Rodler, F., additional, Rodríguez Trinidad, A., additional, Rosich, A., additional, Sadegi, S., additional, Sánchez-Blanco, E., additional, Sánchez Carrasco, M. A., additional, Sánchez-López, A., additional, Sanz-Forcada, J., additional, Sarkis, P., additional, Sarmiento, L. F., additional, Schäfer, S., additional, Schmitt, J. H. M. M., additional, Schöfer, P., additional, Schweitzer, A., additional, Seifert, W., additional, Shulyak, D., additional, Solano, E., additional, Sota, A., additional, Stahl, O., additional, Stock, S., additional, Strachan, J. B. P., additional, Stuber, T., additional, Stürmer, J., additional, Suárez, J. C., additional, Tabernero, H. M., additional, Tala Pinto, M., additional, Trifonov, T., additional, Veredas, G., additional, Vico Linares, J. I., additional, Vilardell, F., additional, Wagner, K., additional, Wolthoff, V., additional, Xu, W., additional, Yan, F., additional, and Zapatero Osorio, M. R., additional
Published: 2019
Full Text: View/download PDF

107. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

Author: Kasner, Scott E, primary, Swaminathan, Balakumar, additional, Lavados, Pablo, additional, Sharma, Mukul, additional, Muir, Keith, additional, Veltkamp, Roland, additional, Ameriso, Sebastian F, additional, Endres, Matthias, additional, Lutsep, Helmi, additional, Messé, Steven R, additional, Spence, J David, additional, Nedeltechev, Krassen, additional, Perera, Kanjana, additional, Santo, Gustavo, additional, Olavarria, Veronica, additional, Lindgren, Arne, additional, Bangdiwala, Shrikant, additional, Shoamanesh, Ashkan, additional, Berkowitz, Scott D, additional, Mundl, Hardi, additional, Connolly, Stuart J, additional, Hart, Robert G, additional, Abdelhamid, N, additional, Abdul Rahman, D, additional, Abdul-Saheb, M, additional, Abreu, P, additional, Abroskina, M, additional, Abu Ahmad, F, additional, Accassat, S, additional, Acciaresi, M, additional, Adami, A, additional, Ahmad, N, additional, Ahmed, F, additional, Alberto Hawkes, M, additional, Alemseged, F, additional, Ali, A, additional, Altavilla, R, additional, Alwis, L, additional, Amarenco, P, additional, Amaro, S, additional, Amaya Sanchez, LE, additional, Amelia Pinto, A, additional, Ameriso, SF, additional, Amin, H, additional, Amino, T, additional, Amjad, AK, additional, Anagnostou, E, additional, Andersen, G, additional, Anderson, C, additional, Anderson, DC, additional, Andrea Falco, M, additional, Andres Mackinnon, F, additional, Andreu, D, additional, Androulakis, M, additional, Angel Gamero, M, additional, Angel Saredo, G, additional, Angeles Diaz, R, additional, Angels Font, M, additional, Anticoli, S, additional, Arauz, A, additional, Arauz Gongora, AA, additional, Araya, P, additional, Arenillas Lara, JF, additional, Arias Rivas, S, additional, Arnold, M, additional, Augustin, S, additional, Avelar, W, additional, Azevedo, E, additional, Babikian, V, additional, Bacellar, A, additional, Badalyan, K, additional, Bae, HJ, additional, Baez Martinez, EM, additional, Bagelmann, H, additional, Bailey, P, additional, Bak, Z, additional, Baker, M, additional, Balazs, A, additional, Baldaranov, D, additional, Balogun, I, additional, Balueva, T, additional, Bankuti, Z, additional, Bar, M, additional, Baranowska, A, additional, Bardutzky, J, additional, Barker Trejo, S, additional, Barlinn, J, additional, Baronnet, F, additional, Barroso, C, additional, Barteys, M, additional, Bartolottiova, T, additional, Barulin, A, additional, Bas, M, additional, Bashir, S, additional, Basile, V, additional, Bathe-Peters, R, additional, Bathula, R, additional, Batista, C, additional, Batur Caglayan, H, additional, Baumgartner, P, additional, Bazan, R, additional, Bazhenova, O, additional, Beaudry, M, additional, Beer, J, additional, Behnam, Y, additional, Beilei, C, additional, Beinlich, A, additional, Bejot, Y, additional, Belkin, A, additional, Benavente, OR, additional, Benjamin, A, additional, Berardi, V, additional, Bereczki, D, additional, Berkowitz, SD, additional, Berlingieri, J, additional, Berrios, W, additional, Berrouschot, J, additional, Bhandari, M, additional, Bhargavah, M, additional, Bicker, H, additional, Bicsak, T, additional, Bilik, M, additional, Bindila, D, additional, Birchenall, J, additional, Birnbaum, L, additional, Black, T, additional, Blacker, D, additional, Blacquiere, D, additional, Blanc-Labarre, C, additional, Blank, C, additional, Blazejewska-Hyzorek, B, additional, Bloch, S, additional, Bodiguel, E, additional, Bogdanov, E, additional, Boos, L, additional, Borcsik, L, additional, Bornstein, N, additional, Bouly, S, additional, Braga, G, additional, Bragado, I, additional, Bravi, MC, additional, Brokalaki, C, additional, Brola, W, additional, Brouns, R, additional, Bruce, D, additional, Brzoska-Mizgalska, J, additional, Buck, B, additional, Buksinska-Lisik, M, additional, Burke, J, additional, Burn, M, additional, Bustamante, G, additional, Cabrejo, L, additional, Cai, K, additional, Cajaraville, S, additional, Calejo, M, additional, Calvet, D, additional, Campillo, J, additional, Campos Costa, E, additional, Camps, P, additional, Can Alaydin, H, additional, Candeloro, E, additional, Canepa, C, additional, Cantu Brito, CG, additional, Cappellari, M, additional, Carcel, C, additional, Cardona Portela, P, additional, Cardoso, F, additional, Carek, M, additional, Carletti, M, additional, Carlos Portilla, J, additional, Caruso, P, additional, Casado-Naranjo, I, additional, Castellini, P, additional, Castro, D, additional, Castro Meira, F, additional, Cavallini, A, additional, Cayuela Caudevilla, N, additional, Cenciarelli, S, additional, Cereda, C, additional, Cerrone, P, additional, Chakrabarti, A, additional, Chaloulos-Iakovidis, P, additional, Chamorro, A, additional, Chandrasena, D, additional, Chang, DI, additional, Che, C, additional, Chembala, J, additional, Chen, J, additional, Chen, Z, additional, Chen, T, additional, Chen, H, additional, Chen, X, additional, Chen, G, additional, Chen, L, additional, Chen, S, additional, Cheripelli, B, additional, Chin, M, additional, Chiquete Anaya, E, additional, Chorazy, M, additional, Christensen, H, additional, Christensen, T, additional, Christian, L, additional, Chu, F, additional, Chung, CS, additional, Clark, W, additional, Clarke, R, additional, Claverie, S, additional, Clemente Agostoni, E, additional, Clissold, B, additional, Coelho, J, additional, Cohen, D, additional, Colakoglu, S, additional, Collas, D, additional, Condurso, R, additional, Connolly, SJ, additional, Consoli, D, additional, Constantin, C, additional, Constantino Silva, AB, additional, Contardo, L, additional, Corlobe, A, additional, Correia, M, additional, Correia, C, additional, Cortijo Garcia, E, additional, Coull, B, additional, Coutts, S, additional, Coveney, S, additional, Cras, P, additional, Crols, R, additional, Crozier, S, additional, Csanyi, A, additional, Csiba, L, additional, Csontos, K, additional, Csuha, R, additional, Cui, L, additional, 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Published: 2018
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108. Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial

Author: Kasner, S. E., Swaminathan, B., Lavados, P., Sharma, M., Muir, K., Veltkamp, R., Ameriso, S. F., Endres, M., Lutsep, H., Messe, S. R., Spence, J. D., Nedeltechev, K., Perera, K., Santo, G., Olavarria, V., Lindgren, A., Bangdiwala, S., Shoamanesh, A., Berkowitz, S. D., Mundl, H., Connolly, S. J., Hart, R. G., Abdelhamid, N., Abdul Rahman, D., Abdul-Saheb, M., Abreu, P., Abroskina, M., Abu Ahmad, F., Accassat, S., Acciaresi, M., Adami, A., Ahmad, N., Ahmed, F., Alberto Hawkes, M., Alemseged, F., Ali, A., Altavilla, R., Alwis, L., Amarenco, P., Amaro, S., Amaya Sanchez, L. E., Amelia Pinto, A., Amin, H., Amino, T., Amjad, A. K., Anagnostou, E., Andersen, G., Anderson, C., Anderson, D. C., Andrea Falco, M., Andres Mackinnon, F., Andreu, D., Androulakis, M., Angel Gamero, M., Angel Saredo, G., Angeles Diaz, R., Angels Font, M., Anticoli, S., Arauz, A., Arauz Gongora, A. A., Araya, P., Arenillas Lara, J. F., Arias Rivas, S., Arnold, M., Augustin, S., Avelar, W., Azevedo, E., Babikian, V., Bacellar, A., Badalyan, K., Bae, H. J., Baez Martinez, E. M., Bagelmann, H., Bailey, P., Bak, Z., Baker, M., Balazs, A., Baldaranov, D., Balogun, I., Balueva, T., Bankuti, Z., Bar, M., Baranowska, A., Bardutzky, J., Barker Trejo, S., Barlinn, J., Baronnet, F., Barroso, C., Barteys, M., Bartolottiova, T., Barulin, A., Bas, M., Bashir, S., Basile, V., Bathe-Peters, R., Bathula, R., Batista, C., Batur Caglayan, H., Baumgartner, P., Bazan, R., Bazhenova, O., Beaudry, M., Beer, J., Behnam, Y., Beilei, C., Beinlich, A., Bejot, Y., Belkin, A., Benavente, O. R., Benjamin, A., Berardi, V., Bereczki, D., Berlingieri, J., Berrios, W., Berrouschot, J., Bhandari, M., Bhargavah, M., Bicker, H., Bicsak, T., Bilik, M., Bindila, D., Birchenall, J., Birnbaum, L., Black, T., Blacker, D., Blacquiere, D., Blanc-Labarre, C., Blank, C., Blazejewska-Hyzorek, B., Bloch, S., Bodiguel, E., Bogdanov, E., Boos, L., Borcsik, L., Bornstein, N., Bouly, S., Braga, G., Bragado, I., Bravi, M. C., Brokalaki, C., Brola, W., Brouns, R., Bruce, D., Brzoska-Mizgalska, J., Buck, B., Buksinska-Lisik, M., Burke, J., Burn, M., Bustamante, G., Cabrejo, L., Cai, K., Cajaraville, S., Calejo, M., Calvet, D., Campillo, J., Campos Costa, E., Camps, P., Can Alaydin, H., Candeloro, E., Canepa, C., Cantu Brito, C. 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S., Heine, M., Held, V., Hellwig, S., Henkner, J., Henninger, N., Hermans, S., Hernandez, J., Herrero, D., Hervieu-Begue, M., Herzig, R., Hicken, L., Hieber, M., Hill, M., Hirose, M., Hobeanu, M. C., Hobson, B., Hochstetter, M., Hoe Heo, J., Hoffmann, M., Holmstedt, C., Hon, P., Hong, K. S., Honma, Y., Horev, A., Horgan, G., Horvath, L., Horvath, M., Hoyer, C., Huang, D., Huang, H., Huber, B., Huhtakangas, J., Hussain, M., Igarashi, S., Iglesias Mohedano, A. M., Ignacio Tembl, J., Impellizzeri, M., Inanc, Y., Ioli, P., Irina Aniculaesei, A., Ishida, K., Itabashi, R., Iversen, H., Jagolino, A., Jakab, K., Jander, S., Janka, H., Jankovych, J., Jansen, J., Jasek, L., Javier Alet, M., Javor, L., Jin, X., Jing, P., Joachim, B., Joan Macleod, M., Johnson, M., Jose Martin, J., Joyner, C., Judit Szabo, K., Jun-Oconnell, A., Jura, R., Kaczorowska, B., Kadlcikova, J., Kahles, T., Kakaletsis, N., Kakuk, I., Kalinowska, K., Kaminska, K., Kaneko, C., Kanellos, I., Kapeller, P., Kapica-Topczewska, K., Karasz, O., Karlinski, M., Karlsson, J. E., Kasa, K., Kashaeva, E., Kaste, M., Kasza, J., Katalin Iljicsov, A., Katsurayama, M., Kaur, S., Kawanishi, M., Kaygorodtseva, S., Ke, K., Kei, A., Keilitz, J., Kellner, J., Kelly, P., Kelly, S., Kemlink, D., Kerekgyarto, M., Keskinarkaus, I., Khairutdinova, D., Khanna, A., Khaw, A., Kholopov, M., Khoumri, C., Kirpicheva, S., Kirshner, H., Kitagawa, K., Kittner, S., Kivioja, R., Klein, F., Kleindorfer, D., Kleinig, T., Klivenyi, P., Knecht, S., Kobayashi, Y., Kobayashi, A., Koch, M., Koehler, L., Koivu, M., Kolianov, V., Koltsov, I., Kondo, T., Konkov, I., Kopecky, S., Korompoki, E., Korpela, J., Kosarz-Lanczek, K., Koutroubi, A., Kovacs, K., Kovacs, T., Kovacs, H., Kowalczyk, K., Kowalska, M., Krajickova, D., Kral, M., Krarup Hansen, C., Kraska, J., Krebs, S., Krejci, V., Kremer, C., Kreuzpointer, R., Krzyzanowska, M., Kucken, D., Kulakowska, A., Kunzmann, J., Kurenkova, N., Kuris, A., Kurkowska-Jastrzebska, I., Kurtenkova, N., Kurushina, O., Kusnick, G., Kustova, M., Kuwashiro, T., Kwan Cha, J., Lago, A., Lagutenko, M., Lajos, B., Lambeck, J., Lamy, C., Landolfi, A., Lanfranconi, S., Lang, W., Lara Lezama, L. B., Lara Rodriguez, B., Largo, T., Lasek-Bal, A., Latte, L., Lauer, V., Le Bouc, R., Leal Cantu, R., Lechner, H., Lecouturier, K., Leder, S., Lee, J., Lee, B. C., Leger, A., Leira, E., Leisse, I., Leker, R., Lembo, G., Lenskaya, L., Leyden, J., Li, G., Li, M., Li, S., Li, J., Liamis, G., Liang, H., Liang, Z., Ligot, N., Lin, H., Lindert, R., Linna, M., Litwin, T., Liu, K., Liu, X., Llull, L., Lohninger, B., Longoni, M., Loomis, C., Lopes, D., Lopez Fernandez, M., Lopez Garza, N., Lord, A., Louw, S., Lovasz, R., Lowenkopf, T., Lu, Z., Lubke-Detring, S. C., Luder, R., Lujan, S., Luo, B., Lupinogina, L., Luschin, G., Lvova, A., Ly, J., Grosse, G. M., Ma, H., Ma, C., Machado, M., Machado, C., Macher, S., Machetanz, J., Macian-Montoro, F., Mackey, E., Mackey, A., Maclean, G., Maestre-Moreno, J., Magadan, A., Magyar, T., Mahagney, A., Majid, A., Majjhoo, A., Makaritsis, K., Mandzia, J., Mangas Guijarro, M., Mangion, D., Manios, E., Mann, S., Manning, L., Manno, C., Manuel Garcia, J., Maqueda, V., Mar Castellanos, M., Mar Freijo, M., Marando, C., Marcela Lepera, S., Marcos Couto, J., Maria Bruera, G., Maria Greco, L., Maria Lorenzo, A., Maria Obmann, S., Maria Roa, A., Marini, C., Marinkovic, I., Mario Sumay, G., Mario Torres, C., Marko, M., Markova, S., Markus, H., Marsh, R., Marsili, E., Marta Esnaola, M., Marta Moreno, J., Marti-Fabregas, J., Martina Angelocola, S., Martinez Sanchez, P., Martinez-Majander, N., Martins, S., Marzelik, O., Mastrocola, S., Matamala, G., Matoltsy, A., Matosevic, B., Matsumoto, S., Maud, A., Mauri Cabdevila, G., May, Z., Mayasi, Y., Mayr, A., Mazzoli, T., Mcarthur, K., Mccullough, L., Medina Pech, C. E., Medlin, F., Mehdiratta, M., Mehta, S., Mehta, D., Mehta, B., Melis, M., Melnikova, E., Mendez, B., Mendonca, T., Mengual Chirifie, J. J., Menon, N., Mensch, A., Meseguer, E., Messe, S., Metcalf, K., Meyer, N., Michas, F., Micheletti, N., Mikulik, R., Milionis, H., Miller, B., Milling, T., Minelli, C., Minhas, J., Minns, M., Mircea, D., Mishra, S., Mismas, A., Mistri, A., Mitrovic, N., Miyake, H., Modrau, B., Moey, A., Molina, C., Molina, J., Molis, A., Moller, J., Molnar, S., Moniche, F., Monosi, C., Monzani, V., Moonis, M., Morais, R., Morales, L., Morales, A., Morar-Precup, D., Moreton, F., Moro, C., Morozova, E., Morton, M., Morvan, T., Morvan, E., Motko, T., Mowla, A., Mozhejko, E., Muddegowda, G., Mudhar, O., Mueller, T., Muhl, C., Muir, K. W., Munoz, S., Murphy, C., Murphy, S., Murtuzova, A., Musuka, T., Mutzenbach, J., Myint, M., Mysliwy, W., Naccarato, M., Naeije, G., Nagakane, Y., Natarajan, I., Navaratnam, D., Nave, A., Nazliel, B., Nedeltchev, K., Nel, J., Nell, H., Nemeth, R., Nemeth, L., Neto, O., Ng, K., Ngeh, J., Nicolas Chialvo, L., Nieminen, T., Nikkanen, M., Nikl, J., Nikoforova, M., Nishino, S., Nishiyama, Y., Njovane, X., Nogawa, S., Nombela, F., Norrving, B., Nosek, K., Nowak, B., Nowakowska-Sledz, E., Ntaios, G., Numminen, H., Nunez, F., Obadia, M., Oberndorfer, S., Obrezan, A., Ochiai, J., Oczkowski, W., O'Donnell, M. J., Odyniec, A., Oh, K., Ohira, M., Okamoto, Y., Okpala, M., Okubo, S., Olah, L., Oleszek, J., Onat Demirci, N., Ondar, V., Ongun, G., Ooyama, K., Orosz, V., Ortiz, R., Osseby, G., Osterlund-Tauriala, E., Ovesen, C., Ozcekic Demirhan, S., Ozdoba-Rot, J., Ozturk, S., Ozyurt, E., Pablo Grecco, M., Pablo Povedano, G., Paciaroni, M., Padiglioni, C., Pagola, J., Palasik, W., Panczel, G., Panos, L., Papadopoulos, G., Papadopoulou, E., Papagiannis, A., Papavasileiou, V., Papina, M., Pardo De Donlebun, J. R., Parisi, V., Park, J. M., Pasten, J., Patel, N., Pavlik, O., Pawelczyk, M., Peacock, W. F., Pei, H., Peisker, T., Pena Sedna, L. 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W., Munoz, S., Murphy, C., Murphy, S., Murtuzova, A., Musuka, T., Mutzenbach, J., Myint, M., Mysliwy, W., Naccarato, M., Naeije, G., Nagakane, Y., Natarajan, I., Navaratnam, D., Nave, A., Nazliel, B., Nedeltchev, K., Nel, J., Nell, H., Nemeth, R., Nemeth, L., Neto, O., Ng, K., Ngeh, J., Nicolas Chialvo, L., Nieminen, T., Nikkanen, M., Nikl, J., Nikoforova, M., Nishino, S., Nishiyama, Y., Njovane, X., Nogawa, S., Nombela, F., Norrving, B., Nosek, K., Nowak, B., Nowakowska-Sledz, E., Ntaios, G., Numminen, H., Nunez, F., Obadia, M., Oberndorfer, S., Obrezan, A., Ochiai, J., Oczkowski, W., O'Donnell, M. J., Odyniec, A., Oh, K., Ohira, M., Okamoto, Y., Okpala, M., Okubo, S., Olah, L., Oleszek, J., Onat Demirci, N., Ondar, V., Ongun, G., Ooyama, K., Orosz, V., Ortiz, R., Osseby, G., Osterlund-Tauriala, E., Ovesen, C., Ozcekic Demirhan, S., Ozdoba-Rot, J., Ozturk, S., Ozyurt, E., Pablo Grecco, M., Pablo Povedano, G., Paciaroni, M., Padiglioni, C., Pagola, J., Palasik, W., Panczel, G., Panos, L., Papadopoulos, G., Papadopoulou, E., Papagiannis, A., Papavasileiou, V., Papina, M., Pardo De Donlebun, J. R., Parisi, V., Park, J. M., Pasten, J., Patel, N., Pavlik, O., Pawelczyk, M., Peacock, W. F., Pei, H., Peisker, T., Pena Sedna, L. F., Penn, A., Pentek, S., Pepper, E., Pereira, L., Perez, Y., Perez, S., Perez Leguizamon, P., Pernicka, M., Perry, R., Persico, A., Pesant, Y., Peska, S., Peters, D., Peters, G., Pettigrew, L., Phan, T., Philippi, S., Phinney, T., Pico, F., Pidal, A., Piechowski-Jozwiak, B., Pieroni, A., Pineiro, S., Piras, V., Pizova, N., Polanco, J., Polin, M., Polyakov, A., Polychronopoulou, E., Polymeris, A., Popov, D., Poppe, A., Postorino, P., Pozzerese, C., Pradhan, M., Prats, L., Prazdnichkova, E., Prendl, B., Pretorius, M., Profice, P., Prokopenko, S., Pudov, E., Pujol Lereis, V., Punzo Bravo, G., Purroy, F., Qiu, J., Qu, X., Quenardelle, V., Quesada Garcia, H., Radrizzani, L., Radtke, A., Raffelsberger, T., Ramirez Moreno, J. M., Ramos-Estebanez, C., Rani, A., Rapantova, P., Rashed, K., Rasheed Nihara, A., Rasmussen, J., Redondo Robles, L., Reif, M., Reiner, P., Rekova, P., Renu, A., Repetto, M., Reyes, P., Reyes Morales, S., Rha, J. H., Ribeiro, J., Ricci, S., Richard, C., Rigual, R., Rinaldi, C., Riveira Rodriguez, C., Rizzato, B., Robinson, T. G., Rocco, A., Rodrigues, M., Rodriguez, G., Rodriguez Campello, A., Rodriguez Lucci, F., Rodriguez Yanez, M., Roesler, C., Roffe, C., Roine, R., Roine, S., Roldan, A., Romana Pezzella, F., Romano, M., Roos, J. S., Rosso, C., Rostrup Kruuse, C., Roth, Y., Roukens, R., Roveri, L., Rozanski, D., Rozniecki, J., Rozsa, C., Rudilosso, S., Ruiz Ares, G., Ruiz Franco, A., Rum, G., Ruuskanen, J., Rybinnik, I., Ryota, K., Saarinen, J., Saavedra, V., Sabben, C., Sabet, A., Sagris, D., Sahlas, J., Sakai, N., Salamanca, P., Salgado, P., Salig, S., Salletmayr, T., Salnikov, M., Samoshkina, O., Samson, Y., Sanak, D., Sanchez Ceron, M., Santalucia, P., Santamaria Cadavid, M., Santiago, P., Sanz Cuesta, B., Sargento, J., Sarraj, A., Sas, K., Sas, A., Satoshi, O., Satsoglou, S., Sattar, N., Savitz, S., Savopoulos, C., Saw, J., Sawicka, M., Sawyer, R., Scandura, T., Schillinger, N., Schindler, J., Schlachetzki, F., Schneider, I., Schuppner, R., Schurig, J., Schwarzbach, C. J., Sebejova, M., Seidel, G., Sekaran, L., Selcuk, D., Selvarajah, J., Semerano, A., Semjen, J., Semushina, D., Sen, S., Seok Park, M., Serena, J., Serhat Tokgoz, O., Serles, W., Serrano, F., Sevin, M., Seynaeve, L., Shah, S., Shamalov, N., Shang, T., Sharrief, A., Shazam Hussain, M., Shchukin, I., Shen, W., Shepeleva, E., Shinsuke, I., Shmonin, A., Shuaib, A., Shulga, A., Sibolt, G., Sibon, I., Sicilia, I., Siebert, M., Sieczkowska, E., Sila, C., Silva, A. A., Silva, D., Silva, P., Silva, Y., Silvestrini, M., Simony, Z., Simpkins, A., Singh, B., Sinha, D., Sipos, I., Skoda, O., Skowron, P., Skowronska, M., Sliwinska, B., Slonkova, J., Smolkin, A., Smyth, A., Sobolewski, P., Sobota, A., Sohn, S. I., Soldatov, M., Solganov, I., Soloveva, L., Solovyeva, E., Sonntag, N., Soors, P., Sorgun, M., Soriano, C., Spence, D., Spengos, K., Sposato, L., Staaf, G., Stadler, K., Stakhovskaya, L., Stamatelopoulos, K., Steinert, S., Stetkarova, I., Stiehm, M., Stocker, R., Stoinski, J., Stoll, A., Stotts, G., Stumpp, A., Sucapane, P., Suenaga, T., Sun, X., Sundararajan, S., Sung Kim, J., Suzuki, H., Svaneborg, N., Szasz, G., Szczuchniak, W., Szczyrba, S., Szegedi, N., Szekely, A., Szewczyk, Z., Szilagyi, G., Szlufik, S., Szoboszlai, K., Szpisjak, L., Sztajzel, R., Sztriha, L., Ta Wil, S. E., Taggeselle, J., Takamatsu, K., Takao, M., Taki, W., Takizawa, S., Talahma, M., Tamayo, A., Tan, J., Tanne, D., Tapanainen, A., Tapiola, T., Tarasiuk, J., Tatlisumak, T., Tayal, A., Tcvetkova, S., Teal, P., Tejada Garcia, J., Tejada Meza, H., Tenora, D., Terceno, M., Terentiou, A., Tezcan, S., Thaler, D., Thomson, A., Thouvenot, E., Tiainen, M., Timberg, I., Timsit, S., Tinchon, A., Tirschwell, D., Togay Isikay, C., Tokunaga, K., Tolino, M., Toloza, C., Tomelleri, G., Tomoyuki, K., Tomppo, L. M., Tong, Z., Tong, L., Toni, D., Torres, J., Tossavainen, C., Toth, G., Tountopoulou, A., Touze, E., Tovar, M., Toyoda, K., Trillo, S., Trommer, A., Tropepi, D., Tryambake, D., Tu, H., Tuetuencue, S., Tumova, R., Tumpula, O., Turc, G., Tutaj, A., Tynkkynen, J., Uchiyama, S., Uchwat, U., Uhrinyakova, L., Ulku Acar, R., Uluduz Ugurlu, D., Urra, X., Urui, S., Usero Ruiz, M., Vaclavik, D., Vahedi, K., Valikovics, A., Valpas, J., Van Acker, P., Van Daele, W., Vanderschueren, G., Vanina Jure, L., Varela, R., Varga, Z., Varvat, J., Varvyanskaya, N., Vasco Salgado, A., Vasko, P., Vass, L., Vassilopoulou, S., Vastagh, I., Vazquez, P., Vecsei, L., Venti, M., Verdugo, M., Verocai, V., Veronica Marroquin, M., Veronica Simonsini, C., Veverka, T., Vigl, M., Vila, A., Vilar, C., Villanueva Osorio, J. A., Virta, J., Vitkova, E., Voglsperger, B., Volna, J., Von Weitzel-Mudersbach, P. A., Vora, N., Voznyuk, I., Wach-Klink, A., Wacongne, A., Walters, D., Wang, Y., Wang, J., Wang, L., Wang, X., Wang, W., Wang, N., Wang, D., Wang, H., Warnack, W., Wartenberg, K., Waters, R., Waters, M., Webb, T., Weber, J., Weiss, G., Weissenborn, K., Weitz, J. I., Weller, B., Wen, G., Weng, G., Werner, P., Werring, D., Wester, P., Whiteley, W., Whiting, R., Wijeratne, T., Willems, C., Wilson, L., Wilson, C., Winder, T., Windt, J., Winkler, A., Winska-Tereszkiewicz, A., Wisniewska, A., Wittayer, M., Wlodek, A., Wojnarowska-Arendt, A., Wolf, M., Wolff, V., Wolter, C., Wong, A., Wook Nah, H., Worthmann, H., Wu, W., Wu, S., Wunderlich, S., Wurzinger, H., Wyse, D. G., Xiao, B., Xiaopeng, W., Ximenez-Carrillo, A., Xiong, L., Xiong, Y., Xiong, W., Xu, Y., Xu, J., Xu, Z., Yalo, B., Yamada, T., Yamasaki, M., Yang, L., Yang, Y., Yang, X., Yang, Q., Yang, B., Yang, J., Yasuhiro, I., Yee Lam, M., Yegappan, C., Yip, S., Ylikallio, E., Ylikotila, P., Yongwon Jin, A., Yoon, B. W., Yoshida, Y., Yperzeele, L., Yuan, H., Yuasa, H., Zalewska, J., Zanferrari, C., Zapata, E., Zboznovits, D., Zelenka, I., Zhang, C., Zhang, B., Zhang, S., Zhang, M., Zhang, X., Zhang, J., Zhao, L., Zhirnova, O., Zhou, L., Zielinska-Turek, J., Zinchenko, I., Ziomek, M., Zitzmann, A., Zweifler, R., Zwiernik, J., and Della Marca G. (ORCID:0000-0001-6914-799X)
Abstract: Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with aspirin among patients with PFO enrolled in the NAVIGATE ESUS trial. Methods: NAVIGATE ESUS was a double-blinded, randomised, phase 3 trial done at 459 centres in 31 countries that assessed the efficacy and safety of rivaroxaban versus aspirin for secondary stroke prevention in patients with ESUS. For this prespecified subgroup analysis, cohorts with and without PFO were defined on the basis of transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE). The primary efficacy outcome was time to recurrent ischaemic stroke between treatment groups. The primary safety outcome was major bleeding, according to the criteria of the International Society of Thrombosis and Haemostasis. The primary analyses were based on the intention-to-treat population. Additionally, we did a systematic review and random-effects meta-analysis of studies in which patients with cryptogenic stroke and PFO were randomly assigned to receive anticoagulant or antiplatelet therapy. Findings: Between Dec 23, 2014, and Sept 20, 2017, 7213 participants were enrolled and assigned to receive rivaroxaban (n=3609) or aspirin (n=3604). Patients were followed up for a mean of 11 months because of early trial termination. PFO was reported as present in 534 (7·4%) patients on the basis of either TTE or TOE. Patients with PFO assigned to receive aspirin had a recurrent ischaemic stroke rate of 4·8 events per 100 person-years compared with 2·6 events per 100 person-years in those treated with rivaroxaban. Among patients with known PFO, there was insufficient evidence to support a difference in risk o
Published: 2018

109. Tetanus immunity among intravenous drug users in Guipuzcoa (Basque Country, Spain)

Author: Gilla, G., Pérez-Trallero, E., Sáenz-Dominguez, J. R., Esparza, H., and Otero, F.
Published: 1994

110. BENTAZEPAM VS. BROMAZEPAM IN ANXIETY DISORDERS (DSM-III)

Author: GONZALEZ, L, MANSO, J, CASTANO, M, HORNERO, C, CASADO, F, LOPEZ, V E, LUNA, S, RODRIGUEZ, M J, GARRIDO, J, OTERO, F J, and VELASCO, J
Published: 1992

111. BENTAZEPAM DOSE RANGE FINDING STUDY IN DSM-III-R ANXIETY DISORDERS. RESULTS IN THE M. H. C. OF MANRESA (BARCELONA)

Author: BONET, P, RODRIGUEZ, C E, GARRIDO, J, OTERO, F J, and VELASCO, J
Published: 1992

112. NIRPS: an adaptive-optics assisted radial velocity spectrograph to chase exoplanets around M-stars

Author: François Bouchy, Jose Luis Rasilla, Nicolas Blind, Willy Benz, L. Genolet, Isabelle Boisse, J. R. De Medeiros, J. I. González Hernández, Otero F. Hernandez, René Doyon, Ph. Vallée, Rafael Rebolo, Francesco Pepe, Simon Thibault, U. Conod, É. Artigau, U. Käufl, A. Segovilla, M. Sarajlic, Alexandre Cabral, Denis Brousseau, S. Bovay, Janis Hagelberg, Francois Wildi, Michael Sordet, V. Reshetov, N. C. Santos, T. Bandy, X. Delfosse, L. Saddlemyer, C. Broeg, C. Melo, P. Figueira, B. Delabre, and L. Malo
Subjects: Physics, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astrophysics, 010402 general chemistry, 01 natural sciences, Exoplanet, 0104 chemical sciences, Starlight, Radial velocity, Stars, Planet, 0103 physical sciences, Astrophysics::Earth and Planetary Astrophysics, Adaptive optics, 010303 astronomy & astrophysics, Circumstellar habitable zone, Spectrograph
Abstract: Since 1st light in 2002, HARPS has been setting the standard in the exo-planet detection by radial velocity (RV) measurements[1]. Based on this experience, our consortium is developing a high accuracy near-infrared RV spectrograph covering YJH bands to detect and characterize low-mass planets in the habitable zone of M dwarfs. It will allow RV measurements at the 1-m/s level and will look for habitable planets around M- type stars by following up the candidates found by the upcoming space missions TESS, CHEOPS and later PLATO. NIRPS and HARPS, working simultaneously on the ESO 3.6m are bound to become a single powerful high-resolution, high-fidelity spectrograph covering from 0.4 to 1.8 micron. NIRPS will complement HARPS in validating earth-like planets found around G and K-type stars whose signal is at the same order of magnitude than the stellar noise. Because at equal resolving power the overall dimensions of a spectrograph vary linearly with the input beam etendue, spectrograph designed for seeing-limited observations are large and expensive. NIRPS will use a high order adaptive optics system to couple the starlight into a fiber corresponding to 0.4” on the sky as efficiently or better than HARPS or ESPRESSO couple the light 0.9” fiber. This allows the spectrograph to be very compact, more thermally stable and less costly. Using a custom tan(θ)=4 dispersion grating in combination with a start-of-the-art Hawaii4RG detector makes NIRPS very efficient with complete coverage of the YJH bands at 110’000 resolution. NIRPS works in a regime that is in-between the usual multi-mode (MM) where 1000’s of modes propagates in the fiber and the single mode well suited for perfect optical systems. This regime called few-modes regime is prone to modal noise- Results from a significant R and D effort made to characterize and circumvent the modal noise show that this contribution to the performance budget shall not preclude the RV performance to be achieved.
Published: 2017

113. Immobilization and Electrochemical Characterization of Coriolopsis Gallica High Redox Potential Laccase

Author: Otero, F., Di Bari, C., Antonio De Lacey, and Pita, M.
Abstract: Editors: Amanda Harris.
Published: 2017

114. Bronquiolitis obliterante en un paciente trabajador de estampación en una fábrica textil

Author: Pérez Fernández, A.M., Castañar Jover, A., Checa Pinilla, J.M., Fuentes Otero, F., and Gómez de Tejada, R.
Published: 2000
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115. P6412Prognostic impact of atrial fibrillation in patients with chronic stable coronary heart disease

Author: Cordero, A, primary, Rodriguez-Manero, M, additional, Castellano, J M, additional, Facila, L, additional, Bertomeu-Gonzalez, V, additional, Otero, F, additional, Lado, M, additional, Allut, G, additional, Galve, E, additional, and Gonzalez-Juanatey, J R, additional
Published: 2018
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116. [Intravenous thrombolysis in ischemic stroke caused by infective endocarditis: a dangerous combination]

Author: Vales M, Garcia-Pastor A, Vazquez-Alen P, Diaz-Otero F, Ja, Villanueva-Osorio, Fernandez-Bullido Y, Redondo N, and Gil-Nunez A
Subjects: Stroke, Endocarditis, Humans, Thrombolytic Therapy, Brain Ischemia
Published: 2016

117. Identificación de los factores que influyen en el retraso intrahospitalario del inicio de trombólisis intravenosa en el ictus agudo en un hospital terciario. Contestación a réplica

Author: Iglesias-Mohedano, A.M., primary, García-Pastor, A., additional, Vázquez-Alen, P., additional, Diaz-Otero, F., additional, Fernández-Bullido, Y., additional, Villanueva-Osorio, J.A., additional, and Gil-Núñez, A., additional
Published: 2017
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118. Factors associated with in-hospital delays in treating acute stroke with intravenous thrombolysis in a tertiary centre. Reply to a letter

Author: Iglesias-Mohedano, A.M., primary, García-Pastor, A., additional, Vázquez-Alen, P., additional, Diaz-Otero, F., additional, Fernández-Bullido, Y., additional, Villanueva-Osorio, J.A., additional, and Gil-Núñez, A., additional
Published: 2017
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119. Impacto del uso universal del videolaringoscopio McGrath como primera opción para todas las intubaciones en el quirófano: prospectiva multicéntrica antes-después del protocolo del estudio VIDEOLAR-SURGERY

Author: Taboada, M., Estany-Gestal, A., Rama-Maceiras, P., Orallo, M.A., Bermúdez, M., Barreiro, C., Gómez, L., Amor, M., Otero, F., Fernández, J., Molins, N., Amate, J.J., Bascuas, B., Rey, R., Alonso, M.C., Castro, M.J., Sarmiento, A., dos Santos, L., Nieto, C., Paredes, S., Velasco, A., Taboada, C., Martín, L., Campaña, D., Mosquera, E., Novoa, C., Varela, S., da Silva, L., Domínguez, E., Bedoya, A., Gómez, A.I., Estévez, M., Martínez, P., Sotojove, R., Naveiro, A., Díaz, C., Ruido, R., Mirón, P., González, M., Francisco, C., Regueira, J., Peiteado, M., Eiras, M., and Paz, E.
Abstract: La intubación traqueal habitual realizada en el quirófano se basa en laringoscopia directa, utilizando un laringoscopio Macintosh. Diversos autores recomiendan el uso universal de un videolaringoscopio como primera opción para todas las intubaciones, independientemente de si el paciente tiene factores predictivos de vía aérea difícil, o no. Nuestra hipótesis fue que el uso del videolaringoscopio McGrath como primera opción de intubación incrementa la frecuencia de pacientes con intubación fácil y reduce las complicaciones asociadas a la intubación.
Published: 2024
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120. Síndrome de cefalea transitoria con déficits neurológicos asociados y pleocitosis en líquido cefalorraquídeo (HaNDL) con cuadro confusional, EEG compatible con afectación difusa y datos de vasoespasmo bilateral en estudio Doppler transcraneal: presentación de un caso y revisión de la literatura

Author: Hidalgo de la Cruz, M., Domínguez Rubio, R., Luque Buzo, E., Díaz Otero, F., Vázquez Alén, P., Orcajo Rincón, J., Prieto Montalvo, J., Contreras Chicote, A., and Grandas Pérez, F.
Abstract: El síndrome de cefalea y déficits neurológicos transitorios con pleocitosis en líquido cefalorraquídeo (acrónimo en inglés, HaNDL) se caracteriza por la presencia de uno o más episodios de cefalea y déficits neurológicos transitorios asociados con linfocitosis en líquido cefalorraquídeo. Hasta la fecha actual se han reportado escasos episodios de HaNDL con clínica compatible con cuadro confusional, y no se encuentran descritas mediciones de Doppler transcraneal (DTC) en pacientes afectos de HaNDL y cuadro confusional. En los registros DTC realizados en pacientes con afectación focal se han objetivado datos indicativos de alteraciones vasomotoras.
Published: 2024
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121. Workload of on-call emergency room neurologists in a Spanish tertiary care centre. A one-year prospective study. Response to a reply

Author: Rodríguez Cruz, P.M., Díaz Otero, F., Ezpeleta, D., García Pastor, A., and Gil Núñez, A.
Published: 2016

122. Labor asistencial del equipo de guardia de neurología en un hospital terciario de Madrid: análisis prospectivo durante un año. Contestación a réplica

Author: Rodríguez Cruz, P.M., Otero, F. Díaz, Ezpeleta, D., Pastor, A. García, and Núñez, A. Gil
Subjects: Clinical Neurology, Neurology (clinical)
Published: 2016

123. Clinical management guidelines for subarachnoid haemorrhage. Diagnosis and treatment

Author: Vivancos, J, Gilo, F, Frutos, R, Maestre, J, Garcia-Pastor, A, Quintana, F, Roda, JM, Ximenez-Carrillo, A, Tejedor, ED, Fuentes, B, de Lecifiana, MA, Alvarez-Sabin, J, Arenillas, J, Calleja, S, Casado, I, Castellanos, M, Castillo, J, Davalos, A, Diaz-Otero, F, Egido, JA, Fernandez, JC, Freijo, M, Gallego, J, Gil-Nunez, A, Lrimia, P, Lago, A, Masjuan, J, Marti-Fabregas, J, Martinez-Sanchez, P, Martinez-Vila, E, Molina, C, Morales, A, Nombela, F, Purroy, F, Ribo, M, Rodriguez-Yafiez, M, Roquer, J, Rubio, F, and Segura, T
Subjects: Subarachnoid haemorrhage, Diagnosis, Delayed cerebral ischaemia, Rebleeding, Vasospasm, Cerebral aneurysm, Medical treatment
Abstract: Objective: To update the Spanish Society of Neurology's guidelines for subarachnoid haemorrhage diagnosis and treatment. Material and methods: A review and analysis of the existing literature. Recommendations are given based on the level of evidence for each study reviewed. Results: The most common cause of spontaneous subarachnoid haemorrhage (SAN) is cerebral aneurysm rupture. Its estimated incidence in Spain is 9/100 000 inhabitants/year with a relative frequency of approximately 5% of all strokes. Hypertension and smoking are the main risk factors. Stroke patients require treatment in a specialised centre. Admission to a stroke unit should be considered for SAH patients whose initial clinical condition is good (Grades I or II on the Hunt and Hess scale). We recommend early exclusion of aneurysms from the circulation. The diagnostic study of choice for SAH is brain CT (computed tomography) without contrast. If the test is negative and SAH is still suspected, a lumbar puncture should then be performed. The diagnostic tests recommended in order to determine the source of the haemorrhage are MRI (magnetic resonance imaging) and angiography. Doppler ultrasonography studies are very useful for diagnosing and monitoring vasospasm. Nimodipine is recommended for preventing delayed cerebral ischaemia. Blood pressure treatment and neurovascular intervention may be considered in treating refractory vasospasm. Conclusions: SAH is a severe and complex disease which must be managed in specialised centres by professionals with ample experience in relevant diagnostic and therapeutic processes. (C) 2012 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.
Published: 2014

124. Metodología de enseñanza de los deportes de invasión en primaria

Author: Otero, F. M., Carmona, J., Albornoz, M., Calvo, A., and Díaz, J. A.
Subjects: Cooperación oposición, Deportes de invasión, Educación Física, Primaria, Metodología, Deportes
Abstract: El objetivo de estudio fue analizar la metodología de enseñanza de los deportes de invasión en Educación Primaria. Para ello, se validó y diseñó un cuestionario con las siguientes dimensiones: cuantificación de la programación sobre deportes invasión y disciplinas impartidas, metodología horizontal o vertical, situaciones de aprendizaje utilizadas y creencias metodológicas. El cuestionario fue respondido por 151 maestros de Educación Física de Sevilla. Los resultados reflejan que los maestros dedican una gran cantidad de su programación a los deportes de invasión. Baloncesto, fútbol y balonmano son las disciplinas más impartidas. Los maestros de Educación Física utilizan mayormente una metodología vertical. Las situaciones de aprendizaje de igualdad numérica son las más utilizadas para enseñar deportes invasión. Por último, las creencias metodológicas de los maestros se orientan hacia un aprendizaje activo. The aim of this study was to analyze teaching methodology in invasion games in Primary Education. For this purpose, a questionnaire with the following parameters was drawn up and validated: Quantification of the programs involving invasion games and disciplines taught, horizontal or vertical methodologies, learning situations and learning situations and methodological approaches used. The questionnaire was answered by 151 physical education teachers in Seville. The results show that teachers the teachers devote a large proportion of their teaching programs to invasion games. Basketball, football and handball are the most taught. A vertical approach is generally applied by physical education teachers. Learning situations of numerical equality are the most used for the teaching of invasion games. Finally, the methodological approaches of the teachers are focused on active learning.
Published: 2014

125. Teacher's methodology of invasion games in primary school

Author: Otero, F. M., Carmona Márquez, José|||0000-0002-2822-516X, Albornoz, M., Calvo, A., and Díaz, J. A.
Subjects: Primary school, Cooperación oposición, Deportes de invasión, Invasion games, Educación Física, Methodology, Primaria, Physical Education, Metodología
Abstract: El objetivo de estudio fue analizar la metodología de enseñanza de los deportes de invasión en Educación Primaria. Para ello, se validó y diseñó un cuestionario con las siguientes dimensiones: cuantificación de la programación sobre deportes invasión y disciplinas impartidas, metodología horizontal o vertical, situaciones de aprendizaje utilizadas y creencias metodológicas. El cuestionario fue respondido por 151 maestros de Educación Física de Sevilla. Los resultados reflejan que los maestros dedican una gran cantidad de su programación a los deportes de invasión. Baloncesto, fútbol y balonmano son las disciplinas más impartidas. Los maestros de Educación Física utilizan mayormente una metodología vertical. Las situaciones de aprendizaje de igualdad numérica son las más utilizadas para enseñar deportes invasión. Por último, las creencias metodológicas de los maestros se orientan hacia un aprendizaje activo. The aim of this study was to analyze teaching methodology in invasion games in Primary Education. For this purpose, a questionnaire with the following parameters was drawn up and validated: Quantification of the programs involving invasion games and disciplines taught, horizontal or vertical methodologies, learning situations and learning situations and methodological approaches used. The questionnaire was answered by 151 physical education teachers in Seville. The results show that teachers the teachers devote a large proportion of their teaching programs to invasion games. Basketball, football and handball are the most taught. A vertical approach is generally applied by physical education teachers. Learning situations of numerical equality are the most used for the teaching of invasion games. Finally, the methodological approaches of the teachers are focused on active learning.
Published: 2014

126. Guidelines for the treatment of acute ischaemic stroke

Author: de Lecinana, MA, Egido, JA, Casado, I, Ribo, M, Davalos, A, Masjuan, J, Caniego, JL, Vila, EM, Tejedor, ED, Alvarez-Sabin, J, Arenillas, J, Calleja, S, Castellanos, M, Castillo, J, Diaz-Otero, F, Lopez-Fernandez, JC, Freijo, M, Gallego, J, Garcia-Pastor, A, Gil-Nunez, A, Gilo, F, Irimia, P, Lago, A, Maestre, J, Marti-Fabregas, J, Martinez-Sanchez, P, Molina, C, Morales, A, Nombela, F, Purroy, F, Rodriguez-Yanez, M, Roquer, J, Rubio, F, Segura, T, Serena, J, Simal, P, Tejada, J, and Vivancos, J
Subjects: Brain protection, Cerebral venous thrombosis, Cerebral infarct, Ischaemic stroke, Thrombolysis, Stroke units
Abstract: Introduction: Update of Acute Ischaemic Stroke Treatment Guidelines of the Spanish Neurological Society based on a critical review of the literature. Recommendations are made based on levels of evidence from published data and studies. Development: Organized systems of care should be implemented to ensure access to the optimal management of all acute stroke patients in stroke units. Standard of care should include treatment of blood pressure (should only be treated if values are over 185/105 mmHg), treatment of hyperglycaemia over 155 mg/dl, and treatment of body temperature with antipyretic drugs if it rises above 37.5 degrees C. Neurological and systemic complications must be prevented and promptly treated. Decompressive hemicraniectomy should be considered in cases of malignant cerebral oedema. Intravenous thrombolysis with rtPA should be administered within 4.5 hours from symptom onset, except when there are contraindications. Intra-arterial pharmacological thrombolysis can be considered within 6 hours, and mechanical thrombectomy within 8 hours from onset, for anterior circulation strokes, while a wider window of opportunity up to 12-24 hours is feasible for posterior strokes. There is not enough evidence to recommend routine use of the so called neuroprotective drugs. Anticoagulation should be administered to patients with cerebral vein thrombosis. Rehabilitation should be started as early as possible. Conclusion: Treatment of acute ischaemic stroke includes management of patients in stroke units. Systemic thrombolysis should be considered within 4.5 hours from symptom onset. Intraarterial approaches with a wider window of opportunity can be an option in certain cases. Protective and restorative therapies are being investigated (C) 2011 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.
Published: 2014

127. Guidelines for the treatment of acute ischaemic stroke

Author: Alonso de Leciñana M, Egido JA, Casado I, Ribó M, Dávalos A, Masjuan J, Caniego JL, Martínez Vila E, Díez Tejedor E, Fuentes B, Álvarez-Sabin J, Arenillas J, Calleja S, Castellanos M, Castillo J, Díaz-Otero F, López-Fernández JC, Freijo M, Gállego J, García-Pastor A, Gil-Núñez A, Gilo F, Irimia P, Lago A, Maestre J, Martí-Fábregas J, Martínez-Sánchez P, Molina C, Morales A, Nombela F, Purroy F, Rodríguez-Yañez M, Roquer J, Rubio F, Segura T, Serena J, Simal P, Tejada J, Vivancos J, and Spanish Neurological Society
Subjects: Brain protection, Cerebral venous thrombosis, Cerebral infarct, Ischaemic stroke, Thrombolysis, Stroke units
Abstract: Introduction: Update of Acute Ischaemic Stroke Treatment Guidelines of the Spanish Neurological Society based on a critical review of the literature. Recommendations are made based on levels of evidence from published data and studies. Development: Organized systems of care should be implemented to ensure access to the optimal management of all acute stroke patients in stroke units. Standard of care should include treatment of blood pressure (should only be treated if values are over 185/105 mmHg), treatment of hyperglycaemia over 155 mg/dl, and treatment of body temperature with antipyretic drugs if it rises above 37.5 degrees C. Neurological and systemic complications must be prevented and promptly treated. Decompressive hemicraniectomy should be considered in cases of malignant cerebral oedema. Intravenous thrombolysis with rtPA should be administered within 4.5 hours from symptom onset, except when there are contraindications. Intra-arterial pharmacological thrombolysis can be considered within 6 hours, and mechanical thrombectomy within 8 hours from onset, for anterior circulation strokes, while a wider window of opportunity up to 12-24 hours is feasible for posterior strokes. There is not enough evidence to recommend routine use of the so called neuroprotective drugs. Anticoagulation should be administered to patients with cerebral vein thrombosis. Rehabilitation should be started as early as possible. Conclusion: Treatment of acute ischaemic stroke includes management of patients in stroke units. Systemic thrombolysis should be considered within 4.5 hours from symptom onset. Intraarterial approaches with a wider window of opportunity can be an option in certain cases. Protective and restorative therapies are being investigated (C) 2011 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.
Published: 2014

128. Guidelines for the preventive treatment of ischaemic stroke and TIA (II). Recommendations according to aetiological sub-type

Author: Fuentes, B, Gallego, J, Gil-Nunez, A, Morales, A, Purroy, F, Roquer, J, Segura, T, Tejada, J, Lago, A, Diez-Tejedor, E, de Lecinana, MA, Alvarez-Sabin, J, Arenillas, J, Calleja, S, Casado, I, Castellanos, M, Castillo, J, Davalos, A, Diaz-Otero, F, Egido, JA, Lopez-Fernandez, JC, Freijo, M, Pastor, AG, Gilo, F, Irimia, P, Maestre, J, Masjuan, J, Marti-Fabregas, J, Martinez-Sanchez, P, Martinez-Vila, E, Molina, C, Nombela, F, Ribo, M, Rodriguez-Yanez, M, Rubio, F, Serena, J, Simal, P, and Vivancos, J
Subjects: Prevention, attack, cardiovascular diseases, Transient ischemic, Guidelines, Ischaemic stroke
Abstract: Background and Objective: To update the ad hoc Committee of the Cerebrovascular Diseases Study Group of The Spanish Neurological Society guidelines on prevention of ischaemic stroke (IS) and Transient Ischaemic Attack (TIA). Methods: We reviewed the available evidence on ischaemic stroke and TIA prevention according to aetiological subtype. Levels of evidence and recommendation levels are based on the classification of the Centre for Evidence-Based Medicine. Results: In atherothrombotic IS, antiplatelet therapy and revascularization procedures in selected cases of ipsilateral carotid stenosis (70%-90%) reduce the risk of recurrences. In cardioembolic IS (atrial fibrillation, valvular diseases, prosthetic valves and myocardial infarction with mural thrombus) prevention is based on the use of oral anticoagulants. Preventive therapies for uncommon causes of IS will depend on the aetiology. In the case of cerebral venous thrombosis oral anticoagulation is effective. Conclusions: We conclude with recommendations for clinical practice in prevention of IS according to the aetiological subtype presented by the patient. (c) 2011 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.
Published: 2014

129. Intravenous thrombolysis in capsular warning syndrome: is it beneficial?

Author: Gutiérrez Ruano, B., García Pastor, A., Villanueva Osorio, J.A., Bravo Quelle, N., Vázquez Alén, P., Díaz Otero, F., and Gil Núñez, A.
Published: 2013
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130. Trombólisis intravenosa en el síndrome de alarma capsular: ¿es beneficiosa?

Author: Gutiérrez Ruano, B., García Pastor, A., Villanueva Osorio, J.A., Bravo Quelle, N., Vázquez Alén, P., Díaz Otero, F., and Gil Núñez, A.
Published: 2013
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131. Dietary differences in individuals buried in a multiethnic neighborhood in Teotihuacan: stable dental isotopes from Teopancazco

Author: Casar, I., primary, Morales, P., additional, Manzanilla, L. R., additional, Cienfuegos, E., additional, and Otero, F., additional
Published: 2016
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132. Workload of on-call emergency room neurologists in a Spanish tertiary care centre. A one-year prospective study. Reply to a letter

Author: Rodríguez Cruz, P.M., primary, Cuello, J.P., additional, Díaz Otero, F., additional, Ezpeleta, D., additional, García Pastor, A., additional, and Gil Núñez, A., additional
Published: 2016
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133. DD-003 Assessment of indicators related to automated dispensing systems

Author: de Palencia, MA Fernandez, primary, Rueda, MM Galindo, additional, Rivadeneyra, M Almanchel, additional, Otero, F Mendoza, additional, Molina, O Garcia, additional, and de La Rubia Nieto, A, additional
Published: 2016
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134. Endovascular treatment of cerebral venous sinus thrombosis (CVST): Is a complete recanalization required for a good clinical outcome?

Author: Lozano-Ros, A., primary, Luque-Buzo, E., additional, García-Pastor, A., additional, Castro-Reyes, E., additional, Díaz-Otero, F., additional, Vázquez-Alen, P., additional, Fernández-Bullido, Y., additional, Villanueva-Osorio, J.A., additional, and Gil-Núñez, A., additional
Published: 2016
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135. Estudio de la miopatía hipotiroidea

Author: Collado Otero, F, Vazquez Martul, María Mercedes, Collado Otero, F, and Vazquez Martul, María Mercedes
Published: 2015

136. Interchannel collisions of strong dispersion-managed solitons with different energies in the presence of higher-order effects.

Author: Diaz-Otero, F. J., Pedrosa-Rodriguez, L., and Guillan-Lorenzo, O.
Published: 2017
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137. Antihypertensive Effect of Long Term Ketanserin in Elderly Essential Hypertensive Patients: Assessment of Left Ventricular Function at Rest and During Exercise

Author: Sánchez, R. A., Otero, F., Ramírez, A. J., Degrossi, O., Glenny, J., and Marcó, E. J.
Published: 1988
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138. Estudio de la estabilidad de tiaprida en disolución para administración en perfusión intravenosa continua

Author: Mendoza-Otero, F., Gómez Vidal, J. A., Vila-Clérigues, N., Muros-Ortega, M., García-Molina, O., and Rubia Nieto, A. De La
Subjects: Tiapride, Mass spectrometry, Tiaprida, Cromatografía líquida de alta eficacia, Espectrometría de masas, Stability study, Estudio de estabilidad, High performance liquid chromatography
Abstract: Objetivo: La tiaprida es una benzamida sustituida clasificada como neuroléptica atípica. Ante la ausencia de datos publicados sobre su estabilidad en disolución para administración en perfusión continua intravenosa, este estudio analiza la estabilidad de la tiaprida en diferentes soluciones para infusión intravenosa, a diferentes concentraciones y durante 48 horas. Método: Se prepararon muestras de tiaprida por triplicado en cloruro sódico al 0,9% y en glucosa al 5% a concentraciones de 1 y 2 mg/mL. Estas muestras se conservaron en recipientes de cristal sin fotoprotección, a temperatura ambiente (25 ± 2ºC). Los tiempos de muestreo a las 0, 1, 3, 6, 12, 24 y 48 horas incluyeron inspección visual y determinación del pH. Se cuantificó la concentración de tiaprida en las muestras mediante cromatografía líquida de alta eficacia acoplada a espectrometría de masas. A los valores de concentración a tiempo 0 se les asignó el valor de referencia del 100%. Se consideraron estables aquellas muestras con concentración de tiaprida superior al 90% de la inicial. Resultados: No se observaron cambios visibles en las muestras analizadas. El valor del pH varió en un rango de entre 0,1 y 0,4 unidades. A las 48 horas, la concentración remanente en cloruro sódico a 1 y 2 mg/mL fue 93,8% y 91,6%, respectivamente. En glucosa al 5%, a 1 y 2 mg/mL fue 96,8% y 94,1%, respectivamente. Conclusión: Las disoluciones de tiaprida en cloruro sódico al 0,9% y en glucosa al 5%, a concentraciones de 1 y 2 mg/mL, en recipientes de cristal sin fotoprotección, a temperatura ambiente, son estables física y químicamente durante 48 horas. Objectives: Tiapride is a substituted benzamide classified as an atypical neuroleptic. To our knowledge, there are no published data on its stability prepared as a continuous intravenous infusion. The current study analysed its stability in two different infusion solutions and concentrations over 48 hours. Method: Triplicate samples of tiapride were prepared in 0.9% sodium chloride and in 5% dextrose solutions at final concentrations of 1 and 2 mg/ml. Samples were collected in glass bottles without photoprotection and at room temperature (25 ± 2ºC). Sampling times at 0, 1, 3, 6, 12, 24 and 48 hours included a visual inspection for colour changes and appearance of precipitation as well as pH determination. Tiapride was quantified at selected times by mass spectrometry using high-performance liquid chro-matography. Concentration values in the samples corresponding to 0 hours were given a reference value of 100%. Concentrations in subsequent samples greater than 90% were considered stable. Results: No colour change or precipitation was observed during the study period. pH values ranged between 0.1 and 0.4 units. At 48 hours, the concentration of remaining tiapride in sodium chloride 1 mg/ml and 2 mg/ml was 93.8% and 91.6%, respectively. That in 5% dextrose 1 mg/ml and 2 mg/ml was 96.8% and 94.1%, respectively. Conclusion: Dilutions of tiapride in 0.9% sodium chloride and in 5% dextrose solution, at concentrations of 1 mg/ml and 2 mg/ml, in glass bottles and at room temperature were stable both physically and chemically during 48 hours.
Published: 2013

139. Clinical practice guidelines in intracerebral haemorrhage

Author: Rodriguez-Yanez, M, Castellanos, M, Freijo, MM, Fernandez, JCL, Marti-Fabregas, J, Nombeta, F, Simal, P, Castillo, J, Fuentes, B, De Lecinana, MA, Alvarez-Sabin, J, Arenillas, J, Calleja, S, Casado, I, Davalos, A, Diaz-Otero, F, Egido, JA, Gallego, J, Pastor, AG, Gil-Nunez, A, Gilo, F, Irimia, P, Lago, A, Maestre, J, Masjuan, J, Martinez-Sanchez, P, Martinez-Vila, E, Molina, C, Morales, A, Purroy, F, Ribo, M, Roquer, J, Rubio, F, Segura, T, Serena, J, Tejada, J, and Vivancoso, J
Subjects: Stroke, Intracerebral haemorrhage, Guidelines
Abstract: Intracerebral haemorrhage accounts for 10%-15% of all strokes; however it has a poor prognisis with higher rates of morbidity and mortality. Neurological deterioration is often observed during the first hours after onset and determines poor prognosis. Intracerebral. haemorrhage, therefore, is a neurological emergency which must be diagnosed and treated properly as soon as possible. In this guide we review the diagnostic procedures and factors that influence the prognosis of patients with intracerebral haemorrhage and we establish recommendations for the therapeutic strategy, systematic diagnosis, acute treatment and secondary prevention for this condition. (C) 2011 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.
Published: 2013

140. Guidelines for the preventive treatment of ischaemic stroke and TIA (I). Update on risk factors and life style

Author: Fuentes, B, Gallego, J, Gil-Nunez, A, Morales, A, Purroy, F, Roquer, J, Segura, T, Tejada, J, Lago, A, Diez-Tejedor, E, de Lecinana, MA, Alvarez-Sabin, J, Arenillas, J, Calleja, S, Casado, I, Castellanos, M, Castillo, J, Davalos, A, Diaz-Otero, F, Egido, JA, Lopez-Fernandez, JC, Freijo, M, Pastor, AG, Gilo, F, Irimia, P, Maestre, J, Masjuan, J, Marti-Fabregas, J, Martinez-Sanchez, P, Martinez-Vila, E, Molina, C, Nombela, F, Ribo, M, Rodriguez-Yanez, M, Rubio, F, Serena, J, Simal, P, and Vivancos, J
Subjects: Prevention, Guidelines, Transient ischemic attack, Ischaemic stroke
Abstract: Objective: To update the ad hoc Committee of the Cerebrovascular Diseases Study Group of The Spanish Neurological Society guidelines on prevention of ischaemic stroke (IS) and transient ischaemic attack (TIA). Methods: We reviewed available evidence on risk factors and means of modifying them to prevent ischaemic stroke and TIA. Levels of evidence and recommendation grades are based on the classification of the Centre for Evidence-Based Medicine. Results: This first section summarises the recommendations for action on the following factors: blood pressure, diabetes, lipids, tobacco and alcohol consumption, diet and physical activity, cardio-embolic diseases, asymptomatic carotid stenosis, hormone replacement therapy and contraceptives, hyperhomocysteinemia, prothrombotic states and sleep apnea syndrome. Conclusions: Changes in lifestyle and pharmacological treatment for hypertension, diabetes mellitus and dyslipidemia, according to criteria of primary and secondary prevention, are recommended for preventing ischemic stroke. (C) 2011 Sociedad Espanola de Neurologia. Published by Elsevier Espana, S.L. All rights reserved.
Published: 2012

141. Numerical modelling of behaviour of carbon nanotube-reinforced composites

Author: Otero, F., Sergio Oller, Martínez, X., and Salomon, O.
Subjects: Finite element method, Plasticity, Plasticity -- Mathematical models, Plasticitat, Elements finits, Mètode dels, Matemàtiques i estadística::Anàlisi numèrica::Mètodes en elements finits [Àrees temàtiques de la UPC], Plasticitat -- Models matemàtics, Carbon nanotubes, Composites, Nano-mechanics
Abstract: Since their discovery by Lijima in 1991[1], carbon nanotubes (CNTs), are considered a new generation of reinforcement [2]. Their "nano" size structure makes them potentially free of defects, which provides them with excellent physical properties [3,4]. There are two main nanotube types: single wall nanotubes (SWNT) and multi wall nanotubes (MWNT). These last ones consist in several concentric walls, one inside the other. In a composite, one the most important factors that condition their mechanical performance is the interfacial tension between matrix and reinforcement. In general, the loads in a composite structure are introduced to the matrix and then are transferred to the reinforcement through the interface [5]. Therefore, the interface can be defined as the region, surrounding the reinforcement, where this stress transfer takes place. The properties of the composite depend on the properties of this region and its ability to transfer the load efficiently. This work proposes a new formulation to predict the mechanical properties and mechanical behaviour of nanotube-reinforced composites. The formulation is based on the mixing theory [6]. It obtains the behaviour of the composite from the mechanical performance of its constitutive materials: matrix, carbon-nanotube and the interface that bonds both of them.
Published: 2011

142. PS-123 Adverse drug reactions causing admission over 11 years in a paediatric hospital

Author: Mendoza Otero, F, primary, Iniesta Navalon, C, additional, García Molina, O, additional, Fernandez De Palencia Espinosa, M, additional, Galindo Rueda, MM, additional, and De La Rubia Nieto, A, additional
Published: 2015
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143. CP-155 Comparative pharmacoeconomics study: tumour necrosis factor -alpha antagonits treatment for rheumatoid arthritis

Author: García Molina, O, primary, Fernandez De Palencia Espinosa, MA, additional, Arocas Casañ, V, additional, Mendoza Otero, F, additional, Mateo Carmona, J, additional, Pellicer Franco, C, additional, and De La Rubia Nieto, A, additional
Published: 2015
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144. PS-045 Study of appropriateness of the indication for parenteral nutrition for adult hospitalised patients

Author: Pellicer Franco, C, primary, de La Cruz Murie, P, additional, Otero, F Mendoza, additional, Molina, O Garcia, additional, Rueda, MM Galindo, additional, Corro, B Garrido, additional, Alvarez, M Blazquez, additional, Casañ, V Arocas, additional, and de la Rubia Nieto, A, additional
Published: 2015
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145. Teacher´s methodology of invasion games in primary school

Author: Universidad de Sevilla. Departamento de Fisioterapia, Otero, F. M., Carmona, J., Albornoz Cabello, Manuel, Calvo, A., Díaz Mancha, Juan Antonio, Universidad de Sevilla. Departamento de Fisioterapia, Otero, F. M., Carmona, J., Albornoz Cabello, Manuel, Calvo, A., and Díaz Mancha, Juan Antonio
Abstract: El objetivo de estudio fue analizar la metodología de enseñanza de los deportes de invasión en Educación Primaria. Para ello, se validó y diseñó un cuestionario con las siguientes dimensiones: cuantificación de la programación sobre deportes invasión y disciplinas impartidas, metodología horizontal o vertical, situaciones de aprendizaje utilizadas y creencias metodológicas. El cuestionario fue respondido por 151 maestros de Educación Física de Sevilla. Los resultados reflejan que los maestros dedican una gran cantidad de su programación a los deportes de invasión. Baloncesto, fútbol y balonmano son las disciplinas más impartidas. Los maestros de Educación Física utilizan mayormente una metodología vertical. Las situaciones de aprendizaje de igualdad numérica son las más utilizadas para enseñar deportes invasión. Por último, las creencias metodológicas de los maestros se orientan hacia un aprendizaje activo., The aim of this study was to analyze teaching methodology in invasion games in Primary Education. For this purpose, a questionnaire with the following parameters was drawn up and validated: Quantification of the programs involving invasion games and disciplines taught, horizontal or vertical methodologies, learning situations and learning situations and methodological approaches used. The questionnaire was answered by 151 physical education teachers in Seville. The results show that teachers the teachers devote a large proportion of their teaching programs to invasion games. Basketball, football and handball are the most taught. A vertical approach is generally applied by physical education teachers. Learning situations of numerical equality are the most used for the teaching of invasion games. Finally, the methodological approaches of the teachers are focused on active learning.
Published: 2014

146. La hipertensión arterial, ¿factor de riesgo para el síndrome serotoninérgico?

Author: Álvarez Omar, A., Anía Lafuente, B.J., Rodríguez Otero, F., and Betancor León, P.
Published: 2011
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147. [Stroke and intracranial stenosis: clinical profile in a series of 134 patients in Spain]

Author: Sánchez-Sánchez C, Jose Egido, Jl, González-Gutiérrez, Mera-Campillo J, Carneado-Ruiz J, and Díaz-Otero F
Subjects: Male, Stroke, Risk Factors, Spain, Humans, Female, Intracranial Arteriosclerosis, Aged, Retrospective Studies
Abstract: Intracranial stenoses (IS) are known to be a manifestation of atherosclerosis and a cause of cerebral ischemia, although very few clinical reports have appeared describing such patients in our milieu.The aim of this study was to describe the vascular risk factors, clinical presentation, radiological characteristics, aetiological role played in strokes and the vessels affected in a series of Spanish patients suffering from stroke and IS.We conducted a retrospective descriptive study of patients admitted to the Cerebrovascular Pathology Unit with strokes and IS between 1990 and 2001. Data collected included: age, sex, arterial hypertension (AHT), diabetes (Db), hypercholesterolemia (HC), smoking (Sm), ischemic or emboligenic heart disease, intermittent claudication, carotid atheromatosis, clinical presentation of stroke and earlier lesions in computerised axial tomography (CAT) scans of the brain.132 patients; 187 stenotic vessels: 65.7% males, mean age 68.3 years. AHT 65%, Db 39%, HC 40%, Sm 43%, ischemic heart disease 22%, emboligenic heart disease 17%, intermittent claudication 13%.TIA 16%, LACI 33%; PACI 25%, TACI 4%, POCI 19%. Significant carotid atheromatosis 26.5%. Symptomatic IS 50%: mean age 63.3 years, 64% females. Arteries affected: vertebral (VA) 28%; middle cerebral (MCA) 27%; carotid siphon 21%; basilar (BA) 10% (65% symptomatic); anterior cerebral (ACA) 5% and posterior cerebral (CPA) 4%. Normal cranial CAT scan 24%, lacunar infarcts 42%, territorial 32%; leukoaraiosis 17%.Patients with stroke and IS display different clinical profiles according to their sex (males: a higher number of vascular risk factors and clinical involvement of other territories; females are more symptomatic, AHT and HC); they usually present clinically as lacunar syndromes, with a scarce amount of significant atheromatous carotid involvement, except IS of the VA, and IS of the BA are the most symptomatic.
Published: 2004

148. COMBINATION OF SEM AND LIGHT SCATTERING DATA FOR THE INVERSE ESTIMATION OF PARTICLE SIZE DISTRIBUTION USING A BAYESIAN APPROACH

Author: Frontini, G. L., additional, Otero, F. A., additional, and Eliçabe, G. E., additional
Published: 2014
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149. Labor asistencial del equipo de guardia de neurología en un hospital terciario de Madrid: análisis prospectivo durante un año

Author: Rodríguez Cruz, P.M., primary, Pérez Sánchez, J.R., additional, Cuello, J.P., additional, Sobrino García, P., additional, Vicente Peracho, G., additional, García Arratibel, A., additional, Sánchez Guzmán, D., additional, Bravo Quelle, N., additional, Gutiérrez Ruano, B., additional, Alarcón Morcillo, C., additional, Cordido Henríquez, F., additional, Romero Delgado, F., additional, Muñoz González, A., additional, Domínguez Rubio, R., additional, Iglesias Mohedano, A.M., additional, Martín Barriga, M.L., additional, de la Casa Fages, B., additional, Díaz Otero, F., additional, Ezpeleta, D., additional, García Pastor, A., additional, and Gil Núñez, A., additional
Published: 2014
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150. Guidelines for the preventive treatment of ischaemic stroke and TIA (II). Recommendations according to aetiological sub-type

Author: Fuentes, B., primary, Gállego, J., additional, Gil-Nuñez, A., additional, Morales, A., additional, Purroy, F., additional, Roquer, J., additional, Segura, T., additional, Tejada, J., additional, Lago, A., additional, Díez-Tejedor, E., additional, Alonso de Lecĩnana, M., additional, Álvarez-Sabin, J., additional, Arenillas, J., additional, Calleja, S., additional, Casado, I., additional, Castellanos, M., additional, Castillo, J., additional, Dávalos, A., additional, Díaz-Otero, F., additional, Egido, J.A., additional, López-Fernández, J.C., additional, Freijo, M., additional, García Pastor, A., additional, Gilo, F., additional, Irimia, P., additional, Maestre, J., additional, Masjuan, J., additional, Martí-Fábregas, J., additional, Martínez-Sánchez, P., additional, Martínez-Vila, E., additional, Molina, C., additional, Nombela, F., additional, Ribó, M., additional, Rodríguez-Yañez, M., additional, Rubio, F., additional, Serena, J., additional, Simal, P., additional, and Vivancos, J., additional
Published: 2014
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