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1,133 results on '"Oscar García"'

102. CAPACITACIÓN DEL MÉDICO GENERAL INTEGRAL EN EL PROGRAMA NACIONAL DE DETECCIÓN PRECOZ DEL CÁNCER BUCAL

Author

Clara Idelette Landrían Díaz, Nelia Espeso Nápoles, Carmen Rosa Hidalgo, and Oscar García Roco Pérez

Subjects
Medicine, Medicine (General), R5-920
Abstract

Se realizó un estudio de intervención a los 12 médicos generales integrales (MGI) que laboran en los consultorios pertenecientes a la Clínica Estomatológica Docente Provincial "Ismael Clark y Mascaró" en Camagüey, desde octubre de 2004 a julio de 2005, con el objetivo de elevar su preparación para ejecutar el Programa Nacional del Cáncer Bucal. La investigación se dividió en tres fases: diagnóstica, intervención y evaluación. A partir del diagnóstico de necesidades de aprendizaje se pudo constatar el nivel de información que tenían los MGI sobre el programa, se diseñó un curso de entrenamiento con modalidad teórico-práctica y se evaluó la competencia y desempeño profesional del Médico General Integral. En los resultados obtenidos, el 58.3 % se autoevaluó erróneamente como bien informado al inicio. Después del entrenamiento, el 70 % mejoró de la categoría poco informado a bien. El desempeño profesional se catalogó como correcto entre el 80 y el 90 % de los médicos, lo que permitió elevar la preparación del MGI para ejecutar el programa de detección precoz del cáncer bucal Se elaboró un folleto didáctico como aporte adicional a la investigación.

Published
2007

103. DISTRACCIÓN OSTEOGÉNICA ALVEOLAR EXPERIMENTAL CON DISPOSITIVO SIMPLE

Author

Oscar García-Roco Pérez, Douglas del Río Méndez, Antonio Pozo Romero, and Alfredo Correa Moreno

Subjects
Medicine, Medicine (General), R5-920
Abstract

Con el objetivo de desarrollar un dispositivo simple con tornillos de distracción para aumentos del reborde alveolar deficitario mediante distracción osteogénica e investigar las reacciones locales de los tejidos se realizó en el Centro de Experimentación Animal del ISCM-Camagüey un ensayo preclínico unicéntrico aleatorizado en 10 perros Beagles certificados y distribuidos por el método de lotería en dos grupos, experimental y control, desde enero a diciembre de 2003. El procedimiento utilizado constó de cuatro etapas: extracción de los premolares mandibulares y alveoloplastia en ambos grupos, para crear un área atrófica que permaneció sin tratamiento en el grupo control. A las 12 semanas osteotomías en el grupo experimental para construir un segmento de transporte rectangular y colocación del distractor. Previo período de latencia de siete días elongación ósea vertical a 1.0 mm/ día durante siete días, y fijación durante ocho semanas. Se realizó evaluación radiográfica e histológica en el sitio de distracción y control. Se logró un aumento vertical promedio de 6.53 ± 0.21 mm después de completar la distracción y de 5.81 ± 0.43 mm alconcluir el período de consolidación, se apreció en el sitio una osteogénesis satisfactoria con hueso maduro. En el grupo control la atrofia alveolar siguió su curso natural, se apreciaron fenómenos de cicatrización y remodelado óseo con una pérdida vertical de 1.05 ± 0.5 mm al evaluarse radiográficamente. Histológicamente no se apreciaron diferencias morfológicas entre los tejidos del sitio quirúrgico y los circundantes. El dispositivo intraoral de distracción en estudio es una técnica novedosa, y los resultados obtenidos son todavía variables, pero experimentalmente resultó eficaz y fiable para conseguir un determinado volumen de masa ósea en una posición predeterminada.

Published
2005

104. LA DIETA Y SU RELEVANCIA EN LA CARIES DENTAL Y LA ENFERMEDAD PERIODONTAL

Author

Maheli Más Sarabia, Mercedes Gómez Meriño, and Oscar García-Roco Pérez

Subjects
Medicine, Medicine (General), R5-920
Abstract

Se realizó una revisión bibliográfica actualizada de treinta documentos, la cual abordó el tema de la relación etiopatogénica que tiene la dieta con los dos problemas de salud bucal más importantes en estomatología: la caries dental y la enfermedad periodontal. La misma pretende ampliar los conocimientos del personal de estomatología sobre el tema, hacer énfasis en la necesidad de modificar estilos insanos de alimentación de la población relacionados con la salud bucal y general e intensificar la labor educativa para prevenir en la comunidad su incidencia mediante el control dietético y la higiene bucal ,así como promover la dieta saludable para nuestros pacientes.

Published
2005

105. Sociedad y Discurso. Revista electrónica del Departamento de Español y Estudios Internacionales. Universidad de Aalborg (Dinamarca). ISSN: 1601-1686. Disponible en: www.discurso.aau.dk.

Author

Oscar García Agustín

Subjects
Education, Education (General), L7-991
Abstract

Sociedad y Discurso. Revista electrónica del Departamento de Español y Estudios Internacionales. Universidad de Aalborg (Dinamarca). ISSN: 1601-1686. Disponible en: www.discurso.aau.dk.

Published
2013
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106. PARÁLISIS FACIAL PERIFÉRICA A FRÍGORI. TERAPIA ACUPUNTURAL

Author

Elvia Isabel Paz Latorre, Oscar García-Roco Pérez, Lázaro Ochoa Undargaraím, and Nelson Aguilar Pasin

Subjects
Medicine, Medicine (General), R5-920
Abstract

Se realizó un ensayo clínico fase III con 93 pacientes de ambos sexos, entre las edades de 5 a 20 años remitidos a la clínica de Medicina Natural y Tradicional del ISCM Carlos J Finlay por las consultas especializadas de Neurología y Maxilo Facial de los hospitales de la provincia Camagüey con el diagnóstico de parálisis facial periférica a frígori en el período comprendido entre enero de 2001 a julio de 2002. La muestra se dividió en dos grupos control y estudio, con 62 y 31 pacientes respectivamente (en una proporción de dos por uno). Los objetivos propuestos fueron determinar la conducta terapéutica a seguir, evaluar el tratamiento y sus resultados y demostrar la efectividad de la terapia acupuntural para lograr la calidad del tratamiento en la parálisis facial periférica a frígori. Concluimos que en las parálisis producidas por cambio de temperatura tratadas con acupuntura su recuperación motora es más rápida, el uso indiscriminado de los esteroides trae consigo mayor número de reacciones adversas no favorables para el desarrollo del niño y mientras más rápido se instaure el tratamiento con acupuntura la recuperación motora de los pacientes es más rápida y mejor será la calidad de nuestros tratamientos.

Published
2004

107. CIRUGÍA MAYOR AMBULATORIA DE GLÁNDULAS SALIVALES

Author

Oscar García-Roco Pérez, Armando Quintana Proenza, Alfredo Correa Moreno, and José Quintana Marrero

Subjects
Medicine, Medicine (General), R5-920
Abstract

Se realizó un estudio observacional descriptivo a 27 pacientes con afecciones en las glándulas salivales, seleccionados para cirugía ambulatoria con el objetivo de valorar los resultados de este procedimiento en el Hospital General Docente "Martín Chang Puga" de Nuevitas, Camagüey, desde marzo de 2000 a septiembre de 2002. Los pacientes siguieron el mecanismo hospitalario instituido para el tratamiento quirúrgico de su enfermedad. La edad media de los pacientes tratados fue 49.3 años, prevaleció el sexo masculino (59.2 %). Las afecciones más frecuentes fueron la sialoadenitis submaxilar crónica (25.9 %) y el adenoma pleomorfo de parótida (48.1 %). La mayoría de los pacientes no presentaron complicaciones (88.9 %), no existió hospitalización imprevista y el proceder proporcionó un alto grado de satisfacción al paciente. El ahorro económico a la institución fue de $ 11362.98 MN.

Published
2004

108. Errors in the Study of the Variational Behavior of Functions in the University Engineering Students

Author

Espino, Alejandro Ecos, Núñez, Joffré Huamán, Moscoso, Braulio Barzola, Chávez, Zoraida Manrique, Alvitez, Alejandro Rumaja, and Cajo, Oscar García

Abstract

The study of the variational behavior of functions constitutes an important element in the understanding of the change of phenomena in real life. His understanding is an essential axis in the mathematical training of university students, especially those who pursue engineering careers. This article presents the results of a study whose objective was to determine the mistakes made by engineering students about the variational behavior of functions. The Duval Semiotics Records Theory was taken as a reference and a questionnaire was prepared with questions about identification of regions of variability for "x" and "y"; regions of growth, decrease, stability, extreme values and, analysis and description of the behavior of the function. The evaluation of the answers was done in a quantitative-qualitative way, from an exploratory and descriptive perspective, with 100 students participating in the civil engineering career. The results indicate that students do not make a real reflection on the variational behavior in intervals of the variables or in a global way. They have difficulty discriminating between the behavior of the function and the location of the function. They present cognitive difficulties that do not allow them to make an adequate conversion from one register to the other. Errors related to mathematical language were found, to the limitations to obtain spatial information, to establish erroneous inferences and to the inadequate development of previous knowledge, which does not allow them to properly evaluate the variational behavior of the functions. [For full proceedings, see ED621941.]

Published
2020

109. Temporal Relation Prediction from Electronic Health Records Using Graph Neural Networks and Transformers Embeddings

Author

Sierra, Óscar García, Galaz, Alfonso Ardoiz, Martín, Miguel Ortega, Rodríguez, Jorge Álvarez, Barriuso, Adrián Alonso, Rattan, Suresh I.S., Editor-in-Chief, Barbagallo, Mario, Editorial Board Member, Çakatay, Ufuk, Editorial Board Member, Fraifeld, Vadim E., Editorial Board Member, Fülöp, Tamàs, Editorial Board Member, Gruber, Jan, Editorial Board Member, Jin, Kunlin, Editorial Board Member, Kaul, Sunil, Editorial Board Member, Kaur, Gurcharan, Editorial Board Member, Le Bourg, Eric, Editorial Board Member, Lopez Lluch, Guillermo, Editorial Board Member, Moskalev, Alexey, Editorial Board Member, Nehlin, Jan, Editorial Board Member, Pawelec, Graham, Editorial Board Member, Rizvi, Syed Ibrahim, Editorial Board Member, Sholl, Jonathan, Editorial Board Member, Stambler, Ilia, Editorial Board Member, Szczerbińska, Katarzyna, Editorial Board Member, Trougakos, Ioannis P., Editorial Board Member, Wadhwa, Renu, Editorial Board Member, Wnuk, Maciej, Editorial Board Member, and Zhavoronkov, Alex, editor

Published
2023
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111. Tratamiento actual de la litiasis vesicular Current treatment of vesicular lithiasis

Author

Oscar García Rodríguez

Subjects
Litiasis vesicular, tratamiento quirúrgico, Vesicular lithiasis, surgical treatment, Surgery, RD1-811
Abstract

El tratamiento quirúrgico de la litiasis vesicular ha cambiado en los últimos años. La incorporación de las nuevas conductas en la práctica médica diaria no siempre es inmediata. Se argumentan las razones relativas a cuándo operar a un paciente con cálculos en la vesícula biliar, y se documenta cómo este procedimiento se reserva fundamentalmente para los pacientes sintomáticos, considerando el dolor como el síntoma por excelencia. También se expone cómo se ha enfrentado este cambio.Surgical treatment of vesicular lithiasis has changed in past years. The addition of the new techniques in daily medical practice not always is immediate. Reasons relative to when to operate a patient presenting with gall bladder calculi are argued and documenting how this procedure is mainly reserved for symptomatic patients where pain is considered as a symptom par excellence . Also, it is exposed how this change has been faced.

Published
2010

116. Ad summam ubertatem vini

Author

Oscar García Sanz

Subjects
Archaeology, CC1-960, Ancient history, D51-90
Abstract

Sin resumen

Published
1991

117. El tratamiento de las fracturas de columna: un estudio de caso ciencia- tecnología- sociedad Treatment of vertebral column fractures: a study on this science-technology-society issue

Author

Marco Antonio Moras Hernández, María Elena Macías Llanes, Alina Monteagudo Canto, and Oscar García Roco

Subjects
CIENCIA, TECNOLOGÍA Y SOCIEDAD, CUBA, FRACTURA DE COLUMNA, SCIENCE, TECHNOLOGY AND SOCIETY, SPINE FRACTURE, Medicine (General), R5-920, Public aspects of medicine, RA1-1270, Social sciences (General), H1-99
Abstract

Es reconocido el principal significado de los estudios sociales: su incidencia en las áreas educativa, en la política científico-tecnológica y también en la investigación, es en esta última que resalta el hecho de permitir la realización de un tipo de reflexividad que retroalimenta a la propia investigación. El presente trabajo coloca como objetivo determinar las condicionantes sociales del proyecto de investigación “Diagnóstico precoz y tratamiento integral de las fracturas de columna” y también sus impactos desde el punto de vista de la interrelación ciencia, tecnología y sociedad. El trabajo tiene la siguiente estructura, en primer lugar se presenta una breve panorámica del marco teórico de los Estudios sociales en los cuáles se moverá el análisis; en segundo lugar, se reflexionará sobre el significado de la fractura de columna como problema de salud y la correspondiente evolución histórica de la cirugía ortopédica para facilitar una mayor comprensión del proyecto de investigación, para finalmente, proporcionar un análisis de las condiciones sociales que a nivel de país y en particular en la provincia de Camaguey han configurado la necesidad social del proyectoThe meaning of social studies is recognized: their incidence in the educational and investigative areas, as well as in the scientific-technological politics. It is in the investigative area that stands out the fact of allowing the carrying out of a discussion that gives feedback to the own investigation. This work places as objective to determine the social conditions of the investigation project “Early diagnosis and integral treatment of spine fractures” and also its impacts from the point of view of the interrelation science, technology and society. The work has the following structure; in the first place a brief panoramic of the theoretical foundations of social studies that will propitiate the analysis is presented. Second, the meaning of spine fractures as a health problem and the consequent historical evolution of orthopedic surgery to facilitate a bigger understanding of the investigation project will be analyzed. Finally, a deep analysis on the conditions that has determined the social necessity of this project in Cuba and specifically in Camagüey

Published
2004

118. Las relaciones ciencia- tecnología- sociedad en el diagnostico temprano del cáncer del pulmón The science-technology-society relationship point of view in the Lung Cancer early diagnosis

Author

Alina Monteagudo Canto, Marcos Antonio Mora, and Oscar García Roco

Subjects
CIENCIA, TECNOLOGÍA Y SOCIEDAD, CUBA, CÁNCER DEL PULMÓN, DIAGNÓSTICO TEMPRANO, SCIENCE, TECHNOLOGY AND SOCIETY, LUNG CANCER, EARLY DIAGNOSIS, Medicine (General), R5-920, Public aspects of medicine, RA1-1270, Social sciences (General), H1-99
Abstract

El trabajo constituye un análisis al proyecto “Diagnóstico temprano del cáncer de pulmón. Establecimiento de un algoritmo de trabajo”. El objetivo general es proporcionar un estudio social desde la perspectiva del enfoque Ciencia Tecnología Sociedad y fundamentar el proyecto como un proyecto de innovación tecnológica de tipo organizacional. Se revelan conceptos necesarios, como tecnología en su visión tradicional y moderna y el de innovación tecnológica. Se analiza al cáncer de pulmón como objeto de estudio de la ciencia medica y de acción tecnológica y se valoran las condiciones sociales que en Cuba propician el estudio del cáncer pulmón, y cómo se manifiesta la transferencia de tecnología en esta esfera de la salud. Para ello se concibe el razonamiento a través del contexto social, económico, político y científico; se reconocen los problemas y las soluciones en la investigación. Por último, se identifican los impactos de la innovación tecnológica. Se trata en el presente trabajo de hacer válida la tesis que los estudios CTS en Cuba constituyen un campo de reflexión y acción de carácter crítico e interdisciplinario relacionado con las influencias que cada contexto sociocultural ejerce sobre el desarrollo de la ciencia y la tecnología y los impactos sociales de estosThis work is an analysis of the project “Early diagnosis of lung cancer. Establishment of a work algorithm”. The general objective is to provide a social study from the perspective of the Science Technology Society approach and to support the project as a project of technological innovation of organizational type. Necessary concepts are revealed, as technology in their traditional and modern vision and that of technological innovation. Lung cancer is analyzed as object of study of medical science and of technological activity. The social conditions that propitiate the study of the cancer lung in Cuba are valued, and how technology transfer is manifested in this area of health. To do so reasoning through the social, economic, political and scientific context is conceived; and problems and solutions are identified in the investigation. Finally, the impacts of technological innovation are identified. This work is intended to make valid the thesis that CTS studies in Cuba are a reflection and action area of critical and interdisciplinary character, related to the influences that each sociocultural context has in the development of science and technology as well as their social impact

Published
2004

119. Tumores de glándulas salivales: Su comportamiento en 10 años de trabajo (1993-2002)

Author

Oscar García-Roco Pérez

Subjects
tumores, glándulas salivales, epidemiología, cavidad bucal, tumor, salivary glands, epidemilogy, oral cavity, Dentistry, RK1-715, Medicine (General), R5-920
Abstract

Se realizó un estudio descriptivo de 107 pacientes que fueron intervenidos quirúrgicamente debido a afecciones en glándulas salivales, durante un período de 10 años, en el Servicio de Cirugía Maxilofacial del Hospital Provincial Docente "Manuel Ascunce Domenech" de Camagüey, con el propósito de describir su frecuencia según edad y sexo, comportamiento biológico, localización anatómica y resultado histopatológico. Hubo predominio de las condiciones neoplásicas benignas en la parótida, mientras que en la submandibular se manifestaron con mayor frecuencia los procesos malignos. El adenoma pleomorfo fue el tumor más frecuente entre las neoplasias benignas y el carcinoma mucoepidermoide, el más común entre las malignas.A descriptive study of 107 patients, who had been surgically treated from salivary gland tumors in the Maxillofacial Surgery Department of "Manuel Ascunce Domenech" provincial teaching hospital located in Camagüey during 10 years, was performed to describe the sex and age distribution and frequency of these tumors, their biological behavior, anatomical location and histopathological outcome. It was observed that benign neoplasias predominated in the parotid glands whereas malignant processes developed more often in submandibular glands. Pleomorphic adenoma was the most found tumor among the benign neoplasias and mucoepidermoid carcinoma was the commonest among the malignant processes.

Published
2003

120. Mixoma osteogénico maxilar: A propósito de un caso

Author

Oscar García-Roco Pérez, Clemente Merino López, Miguel Arredondo López, and Alfredo Correa Moreno

Subjects
mixoma maxilar, mixoma osteogénico maxilar, neoplasmas bucales, tumores, senos maxilares, maxillary myxoma, maxillary osteogenic myxoma, mouth neoplasms, tumors, maxillary sinuses, Dentistry, RK1-715, Medicine (General), R5-920
Abstract

El mixoma osteogénico maxilar es un tumor raro. Teniendo en cuenta la casuística, se considera de interés aportar un nuevo caso. Se revisó el tema. Se reporta el caso de un paciente masculino diagnosticado clínica, imagenológica e histológicamente en el Hospital Interprovincial Docente Clinicoquirúrgico "Manuel Ascunce Domenech" de Camagüey e intervenido quirúrgicamente. Se brindan consideraciones diagnósticas y terapéuticas reportadas en la literatura. El paciente en el momento del reporte está rehabilitado y controlado.Maxillary osteogenic myxoma is a rare tumor, so the presentation of a new case is considered interesting. A literature review was made. Here is the report of the case of a male patient diagnosed with this type of myxoma from clinical, imaging and histological viewpoints at "Manuel Ascunce" teaching clinical-surgical hospital in Camaguey province. He was operated on. Diagnostic and therapeutical explanations provided by literature were given. At the moment of the report, the patient had recovered and was still under medical control.

Published
2003

121. Leiomioma facial: Presentación de un caso

Author

Oscar García-Roco Pérez, Clemente Merino López, Daniel Thompson Grant, and Alfredo Correa Moreno

Subjects
neoplasmas faciales, tumores musculares, leiomioma, facial neoplasms, muscular tumors, leiomyoma, Dentistry, RK1-715, Medicine (General), R5-920
Abstract

Se presenta un caso de leiomioma facial. Hasta el 2002 se habían reportado aproximadamente 70 casos en la región bucal y maxilofacial. Teniendo en cuenta la escasa frecuencia de esta entidad, se consideró de interés aportar un nuevo caso, comentando los aspectos clínicos e histopatológicos. Se realizó una revisión del tema. Se presenta una paciente femenina con diagnóstico de leiomioma facial diagnosticada clínica e histológicamente en el Hospital Provincial Clinicoquirúrgico Docente "Manuel Ascunce Domenech" de Camagüey y que fue tratada quirúrgicamente en dicha institución.A case of facial leiomyoma is reported in this paper. Approximately 70 cases had been reported in the oral and maxillofacial regions until the year 200e. Taking into account the causistry of leiomyoma, we decided to present a new case making comments on clinical and histopathological aspects and to make a literature review in this regard. Here is the case of a female patient diagnosed with facial leiomyoma by clinical and histological means at "Manuel Ascunce" teaching clinical-surgical hospital in Camaguey province where she was also surgically treated.

Published
2003

122. Tumor de Abrikossoff gingival: Reporte de un caso

Author

Oscar García-Roco Pérez

Subjects
tumor de células granualares, neoplasmas gingivales, tumor de Abrikossoff, granular cell tumor, gingival neoplasms, Abrikossoff tumor, Dentistry, RK1-715, Medicine (General), R5-920
Abstract

El tumor de las células granulosas en una rara entidad; existen numerosas teorías sobre su origen que aún están bajo polémica, aunque la más aceptada es la neurogénica, que asimila su procedencia como neuroectodérmico. Se detectó un paciente en consulta con cuadro clínico similar al de esta patología con localización en encía superior, región de premolares. La lesión se mostraba submucosa, elevada, no dolorosa y de aspecto áspero.Tras realizar la exéresis y practicar la biopsia, se corroboró el diagnóstico de un mioblastoma de células granulosas o tumor de Abrikossoff.Granular cell tumors is a rare entity. There is a number of theories on their origin under discussion, but the most accepted is the neurogenic theory that covers the neuroectodermal origin of the tumor. A female patient was detected in outpatient service, who presented with a clinical picture similar to that of this pathology and located in upper gingiva, premolar region. The lesion looked submucosal, raised, painless and rough. After exeresis and biopsy, the diagnosis of granular cell myoblastoma or Abrikossof tumor was confirmed.

Published
2003

123. Citología aspirativa con aguja fina en el diagnóstico de lesiones de tejidos blandos bucales

Author

Oscar García-Roco Pérez, Miguel Arredondo López, Valentín Martínez Bello, and Ana C Pérez Sariol

Subjects
BIOPSIA CON AGUJA, GRANULOMA DE CELULAS, BIOPSY, NEEDLE, GRANULOMA, GIANT CELL, Dentistry, RK1-715, Medicine (General), R5-920
Abstract

El uso de la citología aspirativa con aguja fina (CAAF) en el diagnóstico de muchas lesiones en diferentes partes del organismo está ampliamente extendido, mientras que en lesiones bucales se ha empleado solo muy recientemente. El presente estudio investiga el valor diagnóstico de la CAAF en lesiones bucales sólidas de 71 pacientes (47 masculinos y 24 femeninos) con un rango de edades de 17 a 70 años y se compara con la histología. Las muestras citológicas se evaluaron mediante de la presencia de células diagnósticas y la aplicación de pruebas estadísticas de confiabilidad. Se obtuvieron células diagnósticas en el 73,2 % de las muestras que se dividieron en 2 grandes grupos de lesiones: fibrosas (LF) y no fibrosas (LNF). Entre las LF el diagnóstico fue posible en 15 casos (48,3 %), mientras que en 37 de 40 LNF (94,8 %) se obtuvieron células diagnósticas. Los resultados de las pruebas de confiabilidad difirieron significativamente de acuerdo con el tipo de lesión, mostrando mayor eficiencia (94,8 %) en LNF. Se concluye que la CAAF no tuvo valor diagnóstico en lesiones fibrosas, mientras que en lesiones con estroma blando, rico en vasos o células inflamatorias y en tumores malignos, la CAAF fue muy exitosa, con diagnósticos correctos.The use of fine needle aspiration biopsy cytology (FNABC) in the diagnosis of many lesions in different parts of the organism is widely spread; however, it has only been used in buccal lesiosn recently. The present study deals with the diagnostic value of FNABC in solid buccal lesions of 71 patients (47 males and 24 females) with an age range 17 -70, and it is compared with the histology. The cytological samples were evaluated by the presence of diagnostic cells and the application of reliability statistical tests. Diagnostic cells were obtained in 73.2 % of the samples that were divided into 2 large groups of lesions: fibrous (FL) and non-fibrous (NFL). Among the FL, the diagnosis was possible in 15 cases (48,3 %), whereas in37 of 40 NFL (94.8 %) diagnostic cells were obtained. The results of the reliability tests were significantly different according to the type of lesion, showing higher efficiency in the NFL (94.8 %). It was concluded that the FNABC had no diagnostic values in fibrous lesions, whereas in lesions with soft stroma and cells .rich in vessels or inflammatory cells and malignant tumors, the FNABC was very successful on helping to make correct diagnoses.

Published
2003

124. Incidencia de las lesiones cutáneas malignas faciales

Author

Jorge Luis Zequeira Peña, Oscar García-Roco Pérez, and Miguel Arredondo López

Subjects
NEOPLASMAS FACIALES, INCIDENCIA, FACIAL NEOPLASMS, INCIDENCE, Dentistry, RK1-715, Medicine (General), R5-920
Abstract

Se realiza un estudio de las lesiones malignas de la piel facial en el Servicio de Cirugía Maxilofacial del Hospital "Manuel Ascunce Domenech" de Camagüey en los años 2000 y 2001. La información se obtuvo de 148 historias clínicas con el diagnóstico de lesiones malignas de la piel, de las cuales 42 correspondieron a lesiones de localización facial. La entidad que nos ocupa fue mayor en pacientes mayores de 50 años de edad, blancos, masculinos, con predominio en el tercio medio facial. Los principales tipos histológicos fueron: el carcinoma basocelular y el espinocelular, pero con mayor predominio en el primero. Se revisa el tema y se comparan nuestros resultados con los de otros autores.

Published
2003

125. Infección odontogénica grave: Posibles factores predictores

Author

Oscar García-Roco Pérez, Jorge Luis Zequeira Peña, Lemis Dueñas Rosquete, and Alfredo Correa Moreno

Subjects
ABSCESO PERIAPICAL, PERIAPICAL ABSCESS, Dentistry, RK1-715, Medicine (General), R5-920
Abstract

Se analizaron factores que pudieran predisponer a una infección odontogénica grave que requiera cuidados intensivos. Se realizó un estudio observacional descriptivo a 100 pacientes ingresados consecutivamente con infección odontogénica severa en el Hospital "Manuel Ascunce Domenech" de Camagüey desde 1999 al 2001. A partir de las historias clínicas se estudiaron diferentes variables que incluyeron parámetros médicos, sociales y procedimientos dentales previos. Se prestó particular atención al resultado de los cultivos bacterianos. La edad media de los 59 pacientes masculinos y 41 femeninos fue de 41 ± 15,8 años; 18 pacientes requirieron cuidados intensivos. El 41 % de los pacientes era de bajo nivel de escolaridad; 11 pacientes graves (61,1 %) y 42 no graves (51,2 %) eran fumadores. Dos pacientes (11,1 %) de los graves y 8 (9,8 %) de los no graves referían consumo excesivo de bebidas alcohólicas. La prevalencia de enfermedades crónicas fue mayor entre los no graves (31,7 %). La afección subyacente más común fue la osteítis periapical (70 % de los episodios infecciosos), seguido por la extracción dental en el 27,5 % de los graves y 10,9 % de los no graves. Ninguno de estos factores predijo la necesidad de cuidados intensivos. No existieron diferencias significativas en cuanto a síntomas, demora en solicitar atención médica, procedimientos dentales previos o terapéutica antimicrobiana. Predominaron los estreptococos aerobios (grupo S. milleri) asociados con bacterias anaerobias variadas. No se encontraron variables sociales o clínicas predictoras de un curso grave en infecciones odontogénicas. Todos los pacientes deben ser cuidadosamente monitoreados para evitar complicaciones severas.Those factors that may predispose to a severe odontogenic infection requiring intensive care were analyzed. An observational descriptive study was conducted among 100 patients that were consecutively admitted with severe odontogenic infection at "Manuel Ascunce Domenech" Hospital, in Camagüey, from 1999 to 2001. Different variables, including medical and social parameters and previous dental procedures were studied based on the medical histories. Special emphasis was made on the results of the bacterial cultures. The mean age of the 59 male patients and 41 female patients was of 41 ± 15.8. 18 patients needed intesive care. 41 % of the patients had a low educational level. 11 severe patients (61.1 %) and 42 non-severe (51.2 %) were smokers. 2 patients (11.1 %) of the severe and 8 (9.8 %) of the non-severe drank alcoholic beverage excessively. The prevalence of chronic diseases was higher among the non-severe (31.7 %). The most common underlying affection was periapical osteitis (70 % of the infectious episodes ) followed by tooth extraction in 27.5 % of the severe and 10.9 % of the non-severe. None of these factors predicted the need of intensivce care. There were no significant differences concerning symptoms , delay to request medical attention, previous dental procedures or antimicrobial therapeutics. The aerobial streptococcus (S. Milleri group) associated with varied anaerobial bacteria predominated. No social or clinical variables prediciting a severe course in odontogenic infections were found. All the patients should be carefully monitored to prevent severe complications.

Published
2003

126. Infecciones quirúrgicas en cirugía maxilofacial: Nuestra experiencia

Author

Jorge Luis Zequeira Peña, Oscar García-Roco Pérez, and Miguel Arredondo López

Subjects
INFECCION DE HERIDA OPERATORIA, CIRUGIA BUCAL, INCIDENCIA, SURGICAL WOUND INFECTION, SURGERY, ORAL, INCIDENCE, Dentistry, RK1-715, Medicine (General), R5-920
Abstract

Se realiza un estudio estadístico de 1 026 pacientes operados en el Servicio de Cirugía Maxilofacial del Hospital Provincial "Manuel Ascunce Domenech" en el año 2001, donde se constató infección quirúrgica en 35 de ellos (3,41 %); el mayor número de pacientes correspondió a 26 intervenidos de forma ambulatoria (3,39 %). La entidad nosológica más infectiva fue la cirugía ortognática (22,22 %). No se evidenció relación alguna entre los pacientes infectados y las enfermedades predisponentes.A statistical study was conducted among 1 026 patients that were operated on at the Maxillofacial Surgery Service of "Manuel Ascunce Domenech" Provincial Hospital in 2001. Surgical infection was confirmed in 35 of them (3.41 %). The highest number of patients corresponded to those who had undergone ambulatory surgery (3.39 %). The most infective nosological entity was orthognathic surgery (22.22 %). No relation was found between the infected patients and the predisposing diseases.

Published
2003

129. La Salud Pública en América Latina y El Caribe Public Health in Latin America and the Caribbean

Author

Oscar García-Roco Pérez, Nancy Castañeda González, Zoila Pérez González, and Hilda Labrada Iribarren

Subjects
SALUD PUBLICA, AMERICA LATINA, PUBLIC HEALTH, LATIN AMERICA, Medicine (General), R5-920, Public aspects of medicine, RA1-1270, Social sciences (General), H1-99
Abstract

Se consideran a través de la situación de salud, las características de la Salud Pública en América Latina y el Caribe, su evolución y los hechos que justifican los procesos de reforma del sector, sus fuentes teóricas, la forma en que se desarrollan, y los problemas que enfrentan. Se describen las características esenciales de Colombia, Chile, México, Venezuela y se particulariza en el modelo cubano. Se realiza una reflexión final respecto a la contradictoria situación prevaleciente y se analiza su contexto políticoThe characteristics of Public Health in Latin America and the Caribbean through the present health state of the region is considered. The evolution of these characteristics and the facts that justify the processes of reformation of the sector, as well as their theoretical sources ; the form in which they are developed, and the problems they face are also regarded. The essential characteristics of Colombia, Chile, Mexico, Venezuela and particularly those of the Cuban model are described. A final reflection regarding the contradictory prevalent situation and its political context is made

Published
2002

130. Breve historia de la cirugía bucal y máxilofacial Concise history of buccal and maxillofacial surgery

Author

Oscar García-Roco Pérez and María Josefina Méndez Martínez

Subjects
CIRUGÍA BUCAL, SURGERY ORAL, Medicine (General), R5-920, Public aspects of medicine, RA1-1270, Social sciences (General), H1-99
Abstract

Se realizó una revisión bibliográfica con el objetivo de exponer los valores históricos de la humanidad como fenómeno en movimiento, interacciones y lucha en el conocimiento de los aspectos odontológicos y quirúrgicos, relacionados con los elementos socioeconómicos y culturales que caracterizaron cada período de la historia de la profesión. Este principio pone de manifiesto avances y retrocesos como reflejo de la vida social. La edad antigua esclavista solo garantizaba la atención médica a la clase dominante. En el feudalismo se separan las actividades dentales y quirúrgicas de las médicas por el desprecio a las labores artesanales y de sangre, surgen los barberos y charlatanes. Hasta terminado este período, la base fundamental del conocimiento era el empirismo con una gran influencia de la religión. Ya en la edad moderna se desarrolla la época científica de la odontología, y surge la primera escuela dental; se consolida la Cirugía Maxilofacial como especialidadA bibliographical revision was carried out with the objective of exposing humanity's historical values such as social phenomenon, interactions and struggle in the knowledge of odontological and surgical aspects, related to the socioeconomic and cultural elements that characterized every period in the history of this profession. This principle reveals advances and setbacks that reflect social life. The medical care of the dominant class was the only one guaranteed during slavery. In feudalism dental and surgical activities were separated from the medical ones because of the rejection that existed towards blood and manual labor, which brought about the appearance of barbers. Until the end of this period, the fundamental base of knowledge was empiricism with a great influence of religion. In the modern era the scientific stage of dentistry is developed, and the first dental school arises; being consolidated Maxilofacial Surgery as a specialty

Published
2002

137. Advanced Data Processing of Pancreatic Cancer Data Integrating Ontologies and Machine Learning Techniques to Create Holistic Health Records.

Author

George Manias, Ainhoa Azqueta-Alzúaz, Athanasios Dalianis, Jacob Griffiths, Maritini Kalogerini, Konstantina Kostopoulou, Eleftheria Kouremenou, Pavlos Kranas, Sofoklis A. Kyriazakos, Danae Lekka, Fabio Melillo, Marta Patiño-Martínez, Oscar García Perales, Aristodemos Pnevmatikakis, Salvador Garcia Torrens, Usman Wajid, and Dimosthenis Kyriazis

Published
2024
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139. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

Author

Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, Tarle, Marko, Mamic, Matija, Lorencin, Mia, Luksic, Ivica, Habek, Dubravko, Konjevoda, Suzana, Mihanovic, Jakov, Antoniou, Stavros A, Almezghwi, Heyam A, Gouvas, Nikolaos, Martinek, Lubomir, Novysedlak, Rene, Žatecký, Jan, Meyhoff, Christian S, Ellebæk, Mark Bremholm, Batista, Sylvia Jeanne, Rodriguez, Julia, Mejia De la Cruz, Dolores, Jimenez, Mirna Giselle Santiago, Dominguez, Carla M, Negrete, José R, Campuzano, Pedro N, Mogrovejo, Daniel L, Armas, Maria J, Arboleda-Bustan, Jenny E, Lincango-Naranjo, Eddy P, El-Kassas, Mohamed, Awad, Ahmed K, Alazab, Emad, Abdulmaseh, Kyrillos G, Diab, Sherein, El Wahab, Mostafa HAbd, Darwesh, Amr, Mostafa, Badr E, Abdelgalil, Mahmoud Shaban, Elbadawy, Merihan A, Reda, Ali M, Asla, Amir Fathi, Fayed, Notaila M, Ahmed, Mohamed S, Elsadek, Menan Ahmed, Gad, Dalia Elsayed, El Saadany, Aya Gameel, Elsadek, Aalaa Mohamed, Sayed, Ahmed E, Naeem, Ahmed, Al-Mallah, Abdullah, Abdelsamed, Ahmed A, Ewedah, Moataz, Soliman, Mohamed O, Tanas, Yousef, Hamouda, Mohammed, Mahfouz, Marina H, Abdo, Manal E, Dean, Yomna E, Lka, Karim, Abodeeb, Aya O, Ashoush, Fouad M F B, Elsherbiny, Roqaia R, Gadelkarim, Mohamed, Osman, Nermin A, MIbrahim, Maya, Youssef, Nehal G, Ibrahim, Mohamed Hamdy, Soliman, Antonios, Gadelkareem, Rabea A, Abbas, Ahmed M, Mohamed Hussein, Aliae AR, Abdelsattar, Khaled, Maher, Ahmed, Elabd, Mohamed M, Abdelazim, Hassan, Ibraheem, Maher H, Noureldin, Yasser A, Elfiky, Mahmoud, Ebrahim, Mohamed A, Abdelrahman, Ahmed Saber Mohamed, Marei, Mahmoud Marei, Elkhalawy, Aya M, Azzam, Ahmed Y, Azab, Mohammed A, Elmasry, Ahmed H, Elgazar, Amr, Shalaby, Mahmoud Mohamed Mohamed, Mahmoud, Mohammad S, Qassem, Mohamed G, Kinani, Hussein, Wahba, Abdelrahman M, Ezzat, Rana Hisham, Ahmed, Mai H, Elshawy, Mohamed Elemam, Faragalla, Hazem Metwally, Mahmoud, Khalid D, Nafea, Ahmed M, Abdel-Maboud, Mohamed, Abozied, Hesham, Moharam, Modather, Shehata, Ashraf H, ElKafrawy, Samir A, Tayiawi, Mosaab M, Elghadban, Hosam M, Emara, Moataz M, Shehta, 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2022
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143. Formulation development of a recombinant Streptokinase suppository for hemorrhoids treatment

Author

Ana Aguilera, Yilian Bermudez, Eduardo Martínez, María A Marrero, Lazara Muñoz, Rolando Páez, Beatriz Tamargo, Luciano F Hernández, and Oscar García

Subjects
streptokinase, suppository, hemorrhoids, formulations development, rectal administration, thrombolytic, long term stability, Biotechnology, TP248.13-248.65
Abstract

Recombinant Streptokinase (rSK) is a protein of bacterial origin currently used in the treatment of acute myocardial infarction. Its thrombolytic and anti-inflammatory action makes it attractive for the treatment of hemorrhoids. In this work the influence of absorption enhancer, preservative and emulsifiers on rSK stability was accessed by determining its biological activity under stress conditions. According to the results obtained, were selected as excipients for the formulation: Sodium salicylate as enhancer and anti-inflammatory agent, thimerosal as preservative, Span 60 as emulsifier and Witepsol W25 as suppository base and 100 000 IU per gram of suppository for stability study. Afterwards, three lots at pilot scale were manufactured, packed in aluminum blister shell and stored at 5 ± 3 ºC. Immediately after preparation, the samples were evaluated at months 0, 3, 6, 9, 12 and 18 having into account the physical, chemical and biological properties. The stability study demonstrated that the formulation containing rSK as active pharmaceutical ingredient was stable during 18 months under refrigerated conditions.

144. Quantification and determination of topical delivery of epidermal growth factor from semisolid formulations

Author

Ana Aguilera, Yilian Bermúdez, Oscar García, Rolando Páez, and Eduardo Martínez

Subjects
factor de crecimiento epidérmico, liberación, cuantificación, Biotechnology, TP248.13-248.65
Abstract

In order to obtain a procedure to quantify EGF by ELISA from semisolid formulations different buffers and organic solvents were used, having different polarities and miscibility with water. We studied it from oil-in-water (o/w) cream, water-in-oil (w/o), polyethylene glycol (PEG) ointment, and a jelly. Precision, accuracy and selectivity were determined and variation coefficients were less than 10% after different extraction method with a recovery of 95.54 -108.98%. According to results, it is possible to estimate the EGF concentration with high precision and reproducibility. No statistically significant differences were detected, when compared a placebo extraction solution with the ELISA standard solution demonstrating that placebo does not produce interferences in the quantification of the molecule. To determine the delivery of the active ingredient from different preparations we used a static diffusion cell system to evaluate the release and penetrability of the active ingredient throughout abdominal pig skin. Results showed that release and penetrability of EGF increased proportionally with the hydrosolubility of the vehicle. Therefore, the rate was obtained in jelly, PEG > o/w > w/o. Additionally, PEG ointment and o/w cream allowed the highest distribution of labeled 125I EGF in the epidermis and dermis and receptor medium.

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