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808 results on '"Olutoye, Oluyinka O."'

110. Lignin Composites with Sustained Oxygenation and Reactive Oxygen Species-Scavenging Improve Neovascularization and Healing of Diabetic Wounds

Author

Olutoye, Oluyinka O., primary, Padon, Benjamin W., additional, Short, Walker D., additional, Kaul, Aditya A., additional, Yutzy, Lane D., additional, Faruk, Fayiz, additional, Jung, Olivia S., additional, Kogan, Phillip, additional, Yu, Ling, additional, Li, Hui, additional, Jung, Jangwook P., additional, and Balaji, Swathi, additional

Published
2022
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123. Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model

Author

Rudar, Marko, primary, Naberhuis, Jane K., additional, Suryawan, Agus, additional, Nguyen, Hanh V., additional, Stoll, Barbara, additional, Style, Candace C., additional, Verla, Mariatu A., additional, Olutoye, Oluyinka O., additional, Burrin, Douglas G., additional, Fiorotto, Marta L., additional, and Davis, Teresa A., additional

Published
2021
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127. The exteriorized, CO2-filled human uterus: A new surgical space for fetal surgery?: 51

Author

Belfort, Michael, Whitehead, William E., Shamshirsaz, Alireza A., Keswani, Sundeep G., Ruano, Rodrigo, Espinoza, Jimmy, Olutoye, Olutoyin A., Mann, David, Williams, Erin, Cass, Darrell L., Lee, Tim, Olutoye, Oluyinka O., Carreras, Elena, Welty, Steve, Ayres, Nancy, Bateni, Zhoobin H., Cassady, Christopher, Mehollin-Ray, Amy, Cunningham, Tom, and Peiro, Jose Luis

Published
2016
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129. Comparison between laparoscopically assisted and standard fetoscopic laser ablation in patients with anterior and posterior placentation in twin-twin transfusion syndrome: a single center study

Author

Shamshirsaz, Alireza A., Javadian, Pouya, Ruano, Rodrigo, Haeri, Sina, Sangi-Haghpeykar, Haleh, Lee, Timothy C., Molohon, Jayme, Cass, Darrell L., Salmanian, Bahram, Mollett, Laura, Moaddab, Amirhossein, Espinosa, Jimmy, Olutoye, Oluyinka O., and Belfort, Michael A.

Published
2015
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134. Carbohydrate maldigestion induces necrotizing enterocolitis in preterm pigs

Author

Thymann, Thomas, Moller, Hanne K., Stoll, Barbara, Stay, Ann Cathrine F., Buddington, Randal K., Bering, Stine B., Jensen, Bent B., Olutoye, Oluyinka O., Siggers, Richard H., Molbak, Lars, Sangild, Per T., and Burrin, Douglas G.

Subjects
Carbohydrate metabolism -- Physiological aspects, Enterocolitis, Neonatal necrotizing -- Risk factors, Enterocolitis, Pseudomembranous -- Risk factors, Premature birth -- Complications and side effects, Biological sciences
Abstract

Thymann T, Moller HK, Stoll B, Stoy AC, Buddington RK, Bering SB, Jensen BB, Olutoye OO, Siggers RH, Molbak L, Sangild PT, Burrin DG. Carbohydrate maldigestion induces necrotizing enterocolitis in preterm pigs. Am J Physiol Gastrointest Liver Physiol 297: G1115-G1125, 2009. First published October 1, 2009; doi: 10.1152/ajpgi.00261.2009.--Necrotizing enterocolitis (NEC) remains the most severe gastrointestinal disorder in preterm infants. It is associated with the initiation of enteral nutrition and may be related to immature carbohydrate digestive capacity. We tested the hypothesis that a formula containing maltodextrin vs. a formula containing lactose as the principal source of carbohydrate would predispose preterm pigs to a higher NEC incidence. Cesarean-derived preterm pigs were given total parenteral nutrition for 48 h followed by total enteral nutrition with a lactose-based (n = 11) or maltodextrin-based (n = 11) formula for 36 h. A higher incidence (91% vs. 27%) and severity (score of 3.3 vs. 1.8) of NEC were observed in the maltodextrin than in the lactose group. This higher incidence of NEC in the maltodextrin group was associated with significantly lower activities of lactase, maltase, and aminopeptidase; reduced villus height; transiently reduced in vivo aldohexose uptake; and reduced ex vivo aldohexose uptake capacity in the middle region of the small intestine. Bacterial diversity was low for both diets, but alterations in bacterial composition and luminal concentrations of short-chain fatty acids were observed in the maltodextrin group. In a second study, we quantified net portal absorption of aldohexoses (glucose and galactose) during acute jejunal infusion of a maltodextrin- or a lactose-based formula (n = 8) into preterm pigs. We found lower net portal aldohexose absorption (4% vs. 42%) and greater intestinal recovery of undigested carbohydrate (68% vs. 27%) in pigs acutely perfused with the maltodextrin-based formula than those perfused with the lactose-based formula. The higher digestibility of the lactose than the maltodextrin in the formulas can be attributed to a 5- to 20-fold higher hydrolytic activity of tissue-specific lactase than maltases. We conclude that carbohydrate maldigestion is sufficient to increase the incidence and severity of NEC in preterm pigs. lactose; maltodextrin; premature; enteral nutrition doi: 10.1152/ajpgi.00261.2009

Published
2009

136. Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs

Author

Rudar, Marko, primary, Naberhuis, Jane K., additional, Suryawan, Agus, additional, Nguyen, Hanh V., additional, Stoll, Barbara, additional, Style, Candace C., additional, Verla, Mariatu A., additional, Olutoye, Oluyinka O., additional, Burrin, Douglas G., additional, Fiorotto, Marta L., additional, and Davis, Teresa A., additional

Published
2021
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142. Academic Advancement in Global Surgery: Appointment, Promotion, and Tenure

Author

Wren, Sherry M., primary, Balch, Charles M., additional, Doherty, Gerard M., additional, Finlayson, Samuel R., additional, Kauffman, Gordon L., additional, Kibbe, Melina R., additional, Haider, Adil H., additional, Minter, Rebecca M., additional, Mock, Charles, additional, Muguti, Godfrey I., additional, Numann, Patricia J., additional, Olutoye, Oluyinka O., additional, Roy, Nobhojit, additional, and Weigel, Ronald J., additional

Published
2020
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144. Prenatal Imaging Features and Postnatal Factors Associated with Gastrointestinal Morbidity in Congenital Diaphragmatic Hernia.

Author

Verla, Mariatu A., Style, Candace C., Mehollin-Ray, Amy R., Fallon, Sara C., Vogel, Adam M., Fernandes, Caraciolo J., Ikedionwu, Chioma A., Lee, Timothy C., Keswani, Sundeep G., Olutoye, Oluyinka O., Verla, Mariatu A, Style, Candace C, Mehollin-Ray, Amy R, Fallon, Sara C, Vogel, Adam M, Fernandes, Caraciolo J, Ikedionwu, Chioma A, Lee, Timothy C, Keswani, Sundeep G, and Olutoye, Oluyinka O

Subjects
DIAPHRAGMATIC hernia, FUNDOPLICATION, MANN Whitney U Test, EXTRACORPOREAL membrane oxygenation, DISEASES, GASTROESOPHAGEAL reflux, KRUSKAL-Wallis Test, GASTROPARESIS
Abstract

Background: To perform a comprehensive assessment of postnatal gastrointestinal (GI) morbidity and determine the prenatal imaging features and postnatal factors associated with its development in patients with congenital diaphragmatic hernia (CDH).Materials and Methods: A retrospective review was conducted of all infants evaluated for CDH at a quaternary fetal center from February 2004 to May 2017. Prenatal imaging features and postnatal variables were analyzed. GI morbidity was the primary outcome. The Mann-Whitney U test, the Kruskal-Wallis test with Dunnett's T3 post hoc analysis and logistic regression, and the χ2 test were performed when appropriate.Results: We evaluated 256 infants; 191 (75%) underwent CDH repair and had at least 6 months of follow-up. Of this cohort, 60% had gastroesophageal reflux disease (GERD), 13% had gastroparesis, 32% received a gastrostomy tube (G-tube), and 17% needed a fundoplication. Large defect, patch repair, extracorporeal membrane oxygenation (ECMO), and prolonged use of mechanical ventilation were significantly associated with having GERD, gastroparesis, G-tube placement, and fundoplication (p < 0.05). Fetuses with stomach grades 3 and 4 were most likely to have GERD, a G-tube, and a long-term need for supplemental nutrition than fetuses with stomach grades 1 and 2 (p < 0.05).Conclusion: Survivors of CDH with large defects, prolonged use of mechanical ventilation, or that have received ECMO may be at an increased risk for having GERD, gastroparesis, and major GI surgery. Marked stomach displacement on prenatal imaging is significantly associated with GI morbidity in left-sided CDH. [ABSTRACT FROM AUTHOR]

Published
2020
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145. Timing of Prenatal Magnetic Resonance Imaging in the Assessment of Congenital Diaphragmatic Hernia.

Author

Style, Candace C., Mehollin-Ray, Amy R., Verla, Mariatu A., Lau, Patricio E., Cruz, Stephanie M., Espinoza, Jimmy, Lee, Timothy C., Fernandes, Caraciolo J., Keswani, Sundeep G., Olutoye, Oluyinka O., Style, Candace C, Mehollin-Ray, Amy R, Verla, Mariatu A, Lau, Patricio E, Cruz, Stephanie M, Lee, Timothy C, Fernandes, Caraciolo J, Keswani, Sundeep G, and Olutoye, Oluyinka O

Subjects
DIAPHRAGMATIC hernia, MAGNETIC resonance imaging, FETAL MRI, LUNG volume, EXTRACORPOREAL membrane oxygenation
Abstract

Introduction: Fetal magnetic resonance imaging (MRI) has been used to stratify severity of congenital diaphragmatic hernia (CDH) after ultrasound diagnosis. The purpose of this study was to determine if timing of MRI influenced prediction of severity of outcome in CDH.Methods: A single institution retrospective review of all CDH referred to our institution from February 2004 to May 2017 was performed. Patients were included if they underwent at least 2 fetal MRIs prior to delivery. Prenatal MRI indices including observed-to-expected total fetal lung volume (o/e TFLV) were evaluated. Indices were categorized by trimester, either 2nd (20-27 weeks gestation) or 3rd trimester (>28 weeks gestation) and further analyzed for outcome predictability. Primary outcomes were survival, extracorporeal membrane oxygenation (ECMO), and pulmonary hypertension (PAH). Student t test and logistic and linear regression were used for data analyses.Results: Of 256 fetuses evaluated for CDH, 197 were further characterized by MRI with 57 having both an MRI in the 2nd and 3rd trimesters. There was an average of 9.95 weeks (±4.3) between the 1st and 2nd MRI. Second trimester o/e TFLV was the only independent predictor of survival by logistic regression (OR 0.890, p < 0.01). Third trimester MRI derived lung volumes were associated with, and independent predictors of, severity of PAH and need for ECMO. Interval TFLV growth was a strong predictor of PAH postnatally (OR 0.361, p < 0.01). Overall cohort survival was 79%.Conclusion: Accuracy of MRI lung volumes to predict outcomes is dependent on the -gestational age at the time of exam. While MRI lung volumes at either the 2nd or 3rd trimester are predictive of morbidity, 2nd trimester lung volumes strongly correlated with mortality. [ABSTRACT FROM AUTHOR]

Published
2020
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