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518 results on '"Odde, David J."'

106. SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

Author

Smeester, Branden A., primary, Slipek, Nicholas J., additional, Pomeroy, Emily J., additional, Bomberger, Heather E., additional, Shamsan, Ghaidan A., additional, Peterson, Joseph J., additional, Crosby, Margaret R., additional, Draper, Garrett M., additional, Becklin, Kelsie L., additional, Rahrmann, Eric P., additional, McCarthy, James B., additional, Odde, David J., additional, Wood, David K., additional, Largaespada, David A., additional, and Moriarity, Branden S., additional

Published
2019
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107. Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

Author

Beckmann, Pauline J., primary, Larson, Jon D., additional, Larsson, Alex T., additional, Ostergaard, Jason P., additional, Wagner, Sandra, additional, Rahrmann, Eric P., additional, Shamsan, Ghaidan A., additional, Otto, George M., additional, Williams, Rory L., additional, Wang, Jun, additional, Lee, Catherine, additional, Tschida, Barbara R., additional, Das, Paramita, additional, Dubuc, Adrian M., additional, Moriarity, Branden S., additional, Picard, Daniel, additional, Wu, Xiaochong, additional, Rodriguez, Fausto J., additional, Rosemarie, Quincy, additional, Krebs, Ryan D., additional, Molan, Amy M., additional, Demer, Addison M., additional, Frees, Michelle M., additional, Rizzardi, Anthony E., additional, Schmechel, Stephen C., additional, Eberhart, Charles G., additional, Jenkins, Robert B., additional, Wechsler-Reya, Robert J., additional, Odde, David J., additional, Huang, Annie, additional, Taylor, Michael D., additional, Sarver, Aaron L., additional, and Largaespada, David A., additional

Published
2019
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114. mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses.

Author

Karam, Basil S., Morris, Rachel S., Bramante, Carolyn T., Puskarich, Michael, Zolfaghari, Emily J., Lotfi‐Emran, Sahar, Ingraham, Nicholas E., Charles, Anthony, Odde, David J., and Tignanelli, Christopher J.

Subjects
COVID-19, CORONAVIRUS disease treatment, RNA viruses, VIRUS diseases, SARS-CoV-2, RAPAMYCIN
Abstract

In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. We discuss the current literature on mTOR in SARS‐CoV‐2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of coronavirus disease 2019. [ABSTRACT FROM AUTHOR]

Published
2021
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119. An Indole–Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules

Author

Cong, Hui, primary, Zhao, Xinghua, additional, Castle, Brian T., additional, Pomeroy, Emily J., additional, Zhou, Bo, additional, Lee, John, additional, Wang, Yi, additional, Bian, Tengfei, additional, Miao, Zhenyuan, additional, Zhang, Wannian, additional, Sham, Yuk Yin, additional, Odde, David J., additional, Eckfeldt, Craig E., additional, Xing, Chengguo, additional, and Zhuang, Chunlin, additional

Published
2018
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132. Shifting the optimal stiffness for cell migration

Author

Bangasser, Benjamin L., primary, Shamsan, Ghaidan A., additional, Chan, Clarence E., additional, Opoku, Kwaku N., additional, Tüzel, Erkan, additional, Schlichtmann, Benjamin W., additional, Kasim, Jesse A., additional, Fuller, Benjamin J., additional, McCullough, Brannon R., additional, Rosenfeld, Steven S., additional, and Odde, David J., additional

Published
2017
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134. Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level

Author

Klank, Rebecca L., primary, Decker Grunke, Stacy A., additional, Bangasser, Benjamin L., additional, Forster, Colleen L., additional, Price, Matthew A., additional, Odde, Thomas J., additional, SantaCruz, Karen S., additional, Rosenfeld, Steven S., additional, Canoll, Peter, additional, Turley, Eva A., additional, McCarthy, James B., additional, Ohlfest, John R., additional, and Odde, David J., additional

Published
2017
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137. Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma

Author

Marko, Tracy A., primary, Shamsan, Ghaidan A., additional, Edwards, Elizabeth N., additional, Hazelton, Paige E., additional, Rathe, Susan K., additional, Cornax, Ingrid, additional, Overn, Paula R., additional, Varshney, Jyotika, additional, Diessner, Brandon J., additional, Moriarity, Branden S., additional, O’Sullivan, M. Gerard, additional, Odde, David J., additional, and Largaespada, David A., additional

Published
2016
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139. Rapid diffusion-state switching underlies stable cytoplasmic gradients in the Caenorhabditis elegans zygote.

Author

Youjun Wu, Bingjie Han, Younan Li, Munro, Edwin, Odde, David J., and Griffin, Erik E.

Subjects
CAENORHABDITIS elegans, CELL membranes, MOLECULAR biology, MICROTUBULES, CELL proliferation
Abstract

Protein concentration gradients organize cells and tissues and commonly form through diffusion away from a local source of protein. Interestingly, during the asymmetric division of the Caenorhabditis elegans zygote, the RNA-binding proteins MEX- 5 and PIE-1 form opposing concentration gradients in the absence of a local source. In this study, we use near-total internal reflection fluorescence (TIRF) imaging and single-particle tracking to characterize the reaction/diffusion dynamics that maintain the MEX- 5 and PIE-1 gradients. Our findings suggest that both proteins interconvert between fast-diffusing and slow-diffusing states on timescales that are much shorter (seconds) than the timescale of gradient formation (minutes). The kinetics of diffusion-state switching are strongly polarized along the anterior/posterior (A/ P) axis by the PAR polarity system such that fast-diffusing MEX- 5 and PIE-1 particles are approximately symmetrically distributed, whereas slow-diffusing particles are highly enriched in the anterior and posterior cytoplasm, respectively. Using mathematical modeling, we show that local differences in the kinetics of diffusion-state switching can rapidly generate stable concentration gradients over a broad range of spatial and temporal scales. [ABSTRACT FROM AUTHOR]

Published
2018
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140. Kinesin-5 Mediated Chromosome Congression in Insect Spindles.

Author

Tubman, Emily, He, Yungui, Hays, Thomas S., and Odde, David J.

Subjects
MICROTUBULE-associated protein kinase, CHROMOSOMES, RNA interference, DROSOPHILA melanogaster, KINETOCHORE
Abstract

Introduction: The microtubule motor protein kinesin-5 is well known to establish the bipolar spindle by outward sliding of antiparallel interpolar microtubules. In yeast, kinesin-5 also facilitates chromosome alignment 'congression' at the spindle equator by preferentially depolymerizing long kinetochore microtubules (kMTs). The motor protein kinesin-8 has also been linked to chromosome congression. Therefore, we sought to determine whether kinesin-5 or kinesin-8 facilitates chromosome congression in insect spindles. Methods: RNAi of the kinesin-5 Klp61F and kinesin-8 Klp67A were performed separately in Drosophila melanogaster S2 cells to test for inhibited chromosome congression. Klp61F RNAi, Klp67A RNAi, and control metaphase mitotic spindles expressing fluorescent tubulin and fluorescent Cid were imaged, and their fluorescence distributions were compared. Results: RNAi of Klp61F with a weak Klp61F knockdown resulted in longer kMTs and less congressed kinetochores compared to control over a range of conditions, consistent with kinesin-5 length-dependent depolymerase activity. RNAi of the kinesin-8 Klp67A revealed that kMTs relative to the spindle lengths were not longer compared to control, but rather that the spindles were longer, indicating that Klp67A acts preferentially as a length-dependent depolymerase on interpolar microtubules without significantly affecting kMT length and chromosome congression. Conclusions: This study demonstrates that in addition to establishing the bipolar spindle, kinesin-5 regulates kMT length to facilitate chromosome congression in insect spindles. It expands on previous yeast studies, and it expands the role of kinesin-5 to include kMT assembly regulation in eukaryotic mitosis. [ABSTRACT FROM AUTHOR]

Published
2018
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144. Optimal cell traction forces in a generalized motor-clutch model

Author

Alonso-Matilla, Roberto, Provenzano, Paolo P., and Odde, David J.

Abstract

Cells exert forces on mechanically compliant environments to sense stiffness, migrate, and remodel tissue. Cells can sense environmental stiffness via myosin-generated pulling forces acting on F-actin, which is in turn mechanically coupled to the environment via adhesive proteins, akin to a clutch in a drivetrain. In this “motor-clutch” framework, the force transmitted depends on the complex interplay of motor, clutch, and environmental properties. Previous mean-field analysis of the motor-clutch model identified the conditions for optimal stiffness for maximal force transmission via a dimensionless number that combines motor-clutch parameters. However, in this and other previous mean-field analyses, the motor-clutch system is assumed to have balanced motors and clutches and did not consider force-dependent clutch reinforcement and catch bond behavior. Here, we generalize the motor-clutch analytical framework to include imbalanced motor-clutch regimes, with clutch reinforcement and catch bonding, and investigate optimality with respect to all parameters. We found that traction force is strongly influenced by clutch stiffness, and we discovered an optimal clutch stiffness that maximizes traction force, suggesting that cells could tune their clutch mechanical properties to perform a specific function. The results provide guidance for maximizing the accuracy of cell-generated force measurements via molecular tension sensors by designing their mechanosensitive linker peptide to be as stiff as possible. In addition, we found that, on rigid substrates, the mean-field analysis identifies optimal motor properties, suggesting that cells could regulate their myosin repertoire and activity to maximize force transmission. Finally, we found that clutch reinforcement shifts the optimum substrate stiffness to larger values, whereas the optimum substrate stiffness is insensitive to clutch catch bond properties. Overall, our work reveals novel features of the motor-clutch model that can affect the design of molecular tension sensors and provide a generalized analytical framework for predicting and controlling cell adhesion and migration in immunotherapy and cancer.

Published
2024
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