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Introduction. WHO widely draws the attention of the world community to safety culture as an effective basis for ensuring safety in the hospital environment. However, WHO warns that "changing culture is more difficult than introducing new structural and organizational mechanisms". Therefore, systems for assessing patient safety culture in hospitals are widely used in many countries today. The aim of the study. To analyze and compare the dynamics of patient safety culture in Ukraine and the USA healthcare facilities. Materials and methods. The study utilized bibliographic, statistical, and sociological research methods. The research material consisted of a questionnaire survey of medical personnel on patient safety culture in 2016 (163 surveys from 3 healthcare facilities) and a questionnaire survey conducted in 2023 (174 surveys from 4 healthcare facilities). Results of patient safety culture monitoring in US hospitals for 2014 and 2021 were used for comparison. The survey of medical personnel was conducted using the AHRQ leadership questionnaire. Results. The percentage of positive responses for 5 out of the 12 characteristics of patient safety culture that we investigated in domestic healthcare facilities in 2023 was significantly lower than in 2016. The main reason for this negative trend in patient safety culture within domestic healthcare facilities can be attributed to the COVID-19 pandemic and Russia's military aggression, but the primary cause lies in the absence of a comprehensive strategy for improving this culture. Over the past 8 years, the proportion of respondents willing to disclose errors in their professional activities, as well as the mistakes of their colleagues and other incidents, without fearing that their mistakes and incident reports will harm them, has remained largely unchanged. The slight trend toward improvement in patient safety culture indicators in US hospitals, despite significant attention to it, indicates the challenges we face in the journey towards forming a positive safety culture. Conclusions. The prevailing reactive safety culture in domestic healthcare, along with the lack of positive changes, hinders the implementation of modern safety strategies in the medical field. The data from our own research and scientific literature highlight the urgent need for in-depth examination of the state of patient safety culture in domestic healthcare facilities and the development of a methodological framework adapted to international standards for evaluating safety culture in medical institutions. The formation of a positive national culture in general, and safety culture within healthcare facilities in particular, should be regarded as a crucial prerequisite for the post-war reconstruction of the country and its integration into the civilized, economically developed global community.

Aim. To study the toxic effect of TiO2 and TiO2-Ag nanopowders on the morphology and elemental composition of the laboratory mice liver. Materials and methods. The study used a model of acute intoxication on laboratory animals. Mice were injected intraperitoneally with TiO2 and TiO2-Ag nanopowders at 4000 mg/kg, 7000 mg/kg, or 10000 mg/kg doses. During two weeks, the animals were observed, lethality was assessed, the accumulation of nanopowder in the organ and the morphology of liver tissues were investigated. The content of titanium and silver in liver samples was determined by optical emission spectroscopy with inductively coupled plasma. Liver tissue micropreparations were examined using an Olympus BX51 light microscope. Also, the micropreparations of the liver were examined by scanning electron microscopy (SEM) using the Tescan Mira 3 device, and the elemental composition was determined using an energy dispersive spectrometer Oxford instrument, X-max 80 mm2. Results. The dependence of the mice lethality on the nanopowders dose was revealed; mortality was higher when exposed to nano-TiO2-Ag compared to nano-TiO2. Average lethal doses were calculated using probit analysis. For nano-TiO2, the LD50 is 4783.30 mg/kg; for nano-TiO2-Ag – 724.44 mg/kg. The accumulation of titanium, titanium, and silver in the liver after exposure to nano-TiO2 and nano-TiO2-Ag was established. In general, there was a tendency to increase the content of titanium in the skin tissue with an increase in the administered dose of nanopowders. Morphological changes in the liver were studied by histological methods. The most characteristic morphological signs of the toxic effect of nano-TiO2 on tissue were dystrophic changes at the level of 67.7 % (cytoplasmic vacuolization in hepatocytes), and when exposed to nano-TiO2-Ag – initial necrotic changes at the level of 70 % (hepatocytes with nuclear pyknosis). It is worth noting that the toxic effect of nano-TiO2 and nano-TiO2-Ag is much less often manifested by focal necrosis and inflammatory reactions (focal infiltration), in some cases, there were adaptive changes that provoked an increase in the number of binuclear hepatocytes. In case of detection agglomerates of a foreign object (crystalline inclusions) were obtained, which were examined spectrally and showed a high content of titanium (Ti). SEM morphometry showed that the size of nanoparticles and their agglomerates ranged from 80 nm to 20 μm. Conclusions. The lethality of mice was higher when the composition of nano-TiO2-Ag was introduced compared to nano-TiO2. Based on the calculated average lethal doses, both nanopowders were assigned to the 3rd class (moderately dangerous) of the danger of chemical substances according to the classification of GOST 12.1.007-76. It was established that with an increase in the injected dose in the tissue of the products of laboratory mice, the accumulation of titanium (under the action of nano-TiO2) and titanium and silver (under the action of nano-TiO2-Ag) increases. Characteristic microscopic signs of the toxic effect of TiO2 and TiO2-Ag nanopowders after intraperitoneal injection in laboratory bags are dystrophic changes in hepatocytes, necrosis of parenchymal disease, while inflammatory reactions occur less often. SEM and the method of elemental mapping of titanium confirmed the presence of TiO2 nanoparticles and their agglomerates in skin tissue when TiO2 nanopowder was administered.

Background. The object of the study is an information-measuring and control system for the synthesis of transparent conductive oxides by spray pyrolysis. The subject of the study is the structure of the specified informationmeasuring and control system. The aim of the work is to increase the controllability of the synthesis of transparent conductive oxides by spray pyrolysis, which is achieved through the development of an improved information and measurement control system for the synthesis of transparent conductive oxides, its hardware and software. Materials and methods. The block diagram of the information-measuring and control system for the synthesis of transparent conductive oxides contains hardware and software parts. In particular, the hardware part consists of blocks necessary for the implementation and control of the spray pyrolysis process, channels for measuring the temperature of the substrate (based on the use of a thermocouple) and electrophysical parameters of synthesized transparent conductive oxides (based on the four-probe method). Results. The structure of the information-measuring and control system for the synthesis of transparent conductive oxides has been developed. Studies of the surface resistance of transparent conductive oxides have been carried out. The structure of the channel for measuring the temperature of the substrate during the spray pyrolysis process has been developed. Conclusions. The developed structure of the information-measuring control system for the synthesis of transparent conductive oxides allows us to solve the following tasks: to select the optimal technological parameters of the coatings being formed; to perform the synthesis of coatings by controlling the technological process; to measure the temperature and electrophysical parameters of transparent conductive coatings.

Background. The study is devoted to the issue of improving the accuracy of automated measuring instruments for the electrical parameters of oxide coatings. In measuring instruments, integrating circuits based on an operational amplifier, which is a universal amplifying device, are used to perform linear mathematical operations on analog signals. The disadvantage of the integrating circuit is the use of an operational amplifier, when using which it is necessary to take into account many parameters and factors that can affect the output signal, and hence the accuracy of the measured value. Materials and methods. Methods of indirect measurement of voltage and current on the studied sample with an oxide coating using the proposed structures of measuring channels are presented. It is shown that the parameters of operational amplifiers have a significant influence on the additive and multiplicative errors of measurement results, for the analysis of which a linear model of an operational amplifier is considered. Results. Based on the metrological analysis of the voltage measurement channel on the test sample, formulas for estimating additive, multiplicative and nonlinear error components are obtained. The contribution of multiplicative and additive parameters of the operational amplifier to the error of measurement results is analyzed in detail. Conclusions. Metrological analysis of the equivalent circuit of an operational amplifier with feedback has been performed, which can be used to estimate additive and multiplicative errors of circuits based on operational amplifiers widely used in instruments and measuring systems. It is shown that the total relative error of the developed channels for measuring current and voltage does not exceed 0.5%, which makes it possible to measure these values of the studied oxide coatings with guaranteed accuracy.

Background. The object of the study is an information - measuring and control system for the synthesis of transparent conductive oxides. The subject of the study is the method of functioning of the specified system designed for the synthesis and measurement of parameters of transparent conductive oxides. The purpose of the work is to increase the controllability of the synthesis of transparent conductive oxides by spray pyrolysis, to improve the reproducibility of coatings obtained on the basis of the spray pyrolysis method. Materials and methods. The development of a methodology for the functioning of an information- measuring and control system for the synthesis of transparent conductive oxides is based on the model proposed by the authors of the relationship between the parameters of the synthesized coatings by technological modes, as well as on the creation of the information content of the system. In turn, the information content of the system consists of databases of functional dependencies of the quality parameters of the created coatings on influencing factors. For example, a database of the dependencies of surface resistance on temperature and on the technological modes of synthesis of transparent conductive oxides has been developed. Results. The method of functioning of the information-measuring and control system for the synthesis of transparent conductive oxides has been developed, which selects the technological modes of application of transparent conductive oxides, as well as measurement and control of the temperature regime and surface resistance of transparent conductive oxides. Conclusions. The developed method of functioning of the information- measuring and control system for the synthesis of transparent conductive oxides allows you to effectively control the process of synthesis of transparent conductive oxides by spray pyrolysis, which guarantees the reproducibility of coatings with specified properties and allows you to control the quality of products based on the measurement of surface resistance.

Molecular genetic research has revolutionized the taxonomy and systematics of the Simuliidae family. Simulium noelleri Friederichs, 1920 is a species of blackfly, common in the Holarctic, reported for 33 countries. In 1954, Topchiev recorded it in Ukraine for the first time. Simulium dolini Usova et Sukhomlin, 1989 has been recorded at the borders of Ukraine and Belarus. It was described for the first time by Usova and Sukhomlin in 1989 from the collection from the territory of Volyn region in 1985. Usova and Sukhomlin, Yankovsky, Adler state that S. noelleri and S. dolini are different species by the morphological characteristics that differ in all phases of development. Adults differ in the structure of the genital appendages, palps, the margin and shape of the face and forehead, the colour of the legs; the larva – in the pattern on the frontal capsule, the number of rays in the fans, mandibular teeth and the hypostoma, the structure of the hind organ of attachment; pupae – in the branching way of gills. Molecular data are becoming an increasingly important tool in insect taxonomy. Therefore, we had to check that these two closely related species also have genetic difference. The development of S. noelleri and S. dolini was studied in four small rivers of Volyn region, Ukraine (Chornohuzka, Konopelka, Putylivka, Omelyanivka) in the period from 2017 to 2019. During initial processing of insect samples, we used the standard protocols EPPO PM7/129. We obtained the nucleotide sequence of S. dolini. It was proved that the populations of S. noelleri and S. dolini from medium and small rivers of Volyn differ in biological, morphological, behavioural and genetic characteristics. Comparison of the species S. noelleri with the data of the GenBank confirms the identification of three distinct morphotypes from Volyn, Great Britain and Canada. As a result of the conducted researches, it was confirmed that two close species of S. dolini and S. noelleri from the noelleri species group differ in the structure of mitochondrial DNA, which confirms their independent taxonomic status. Additional studies comprising more individuals from larger areas of Europe are required to verify the taxonomic position of these two species.

Background. The advantages of the spray-pyrolysis method are the ability to produce films with a high area and a high degree of uniformity at acceptable (from 100 to 500 °C) process temperatures. The method does not require the use of vacuum at all stages of the process. The aim of the study is to select the optimal technological parameters for obtaining transparent conductive coatings based on tin dioxide with minimal surface resistance. Materials and methods. Such technological stages of the process of obtaining samples of transparent conducting oxides based on tin dioxide are presented in the research as preparation of the surface of glass substrates; preparation of precursor solutions; deposition of pure and antimony-doped films of tin dioxide on the surface of substrates. Results. A method for the synthesis of transparent conducting oxides samples based on tin dioxide by the spray-pyrolysis method was developed, and the optimal values of technological parameters aimed at achieving the minimum surface resistance of samples with a SnO2 coating were established empirically. Conclusions. The proposed technological modes make it possible to synthesize by spray pyrolysis transparent conducting oxides based on tin dioxide with a surface resistance RS = 27 Ohm/□, which corresponds to the modern world level of industrially produced transparent conducting coatings based on tin-doped indium oxide. The results obtained confirm the feasibility of manufacturing transparent conductive coatings based on tin dioxide by spray-pyrolysis.

In article the role of a communicative component of educational process and feature of management by its quality each of subjects of educational process is defined. Signs and indicators of quality of a communicative component of educational process to which are carried are defined: use level in educational process of active methods of training and modern technologies, and also extent of creation by teachers of the creative atmosphere for self-development of students. On the basis of the analysis of scientific literature the monitoring procedure "communicativeness of educational process" is developed. Results of realization of monitoring procedure and acceptance on their basis of concrete administrative decisions on increase of interpersonal interaction of subjects of educational process are stated. Recommendations about carrying out actions which will promote increase of communicativeness of educational process are made. Efficiency of monitoring as instrument of quality management of this component of educational process in a higher educational institution is confirmed.

Recent evidence indicates that reward value encoding in humans is highly context dependent, leading to suboptimal decisions in some cases, but whether this computational constraint on valuation is a shared feature of human cognition remains unknown. Here we studied the behaviour of n = 561 individuals from 11 countries of markedly different socioeconomic and cultural makeup. Our findings show that context sensitivity was present in all 11 countries. Suboptimal decisions generated by context manipulation were not explained by risk aversion, as estimated through a separate description-based choice task (that is, lotteries) consisting of matched decision offers. Conversely, risk aversion significantly differed across countries. Overall, our findings suggest that context-dependent reward value encoding is a feature of human cognition that remains consistently present across different countries, as opposed to description-based decision-making, which is more permeable to cultural factors., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)

The main aim of this study was to validate 500 true-false general-knowledge questions in Russian. These norms are valuable to researchers in many fields, as is shown by the impact and relevance of similar norms available in other languages. Although the Russian language is widely spoken, there are no norms available in this language for this type of questions. True-false questions are very useful for measuring semantic memory, among other topics, in neurocognitive studies where there is a trade-off between experimental time and the need for many trials. These types of experimental materials are heavily rooted in cultural background knowledge, making the mere translation from one language to another insufficient. The present research aims to fill this gap. One hundred fifty-five participants answered 500 true-false general knowledge questions split over several consecutive days and three topics: Social Sciences, Natural Sciences, and Culture & Sport. The participants' task was to indicate whether the statements were true or not, as well as the confidence they had in the correctness of their answer. Despite obtaining questions on each of the topics covering all difficulty levels, grouped analyses showed that Social Science's accuracy was higher than for Natural Science's or Culture & Sport questions. In relation to confidence, the grouped perceived difficulty was higher for questions about Culture & Sports when compared with the other two topics. Thus, this study reports and makes available a large pool of Russian true-false general knowledge questions covering different levels of difficulty., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Martín-Luengo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Human societies benefit from social norms that increase cooperation and support social order. Hence, the understanding of effective mechanisms enforcing norms is crucial. One of such mechanisms is "third-party punishment" (TPP) - a form of social punishment that could be delivered by a third-party, not directly affected by the actions of the norm violator. Previous electrophysiological studies (ERP) reported that perceived violations of norms evoked the medial frontal negativity in third-parties. The current study further probed the link between the medial frontal negativity (MFN) and actual TPP of norm violation, as it was not shown directly before. Participants played a dictator game as third-parties, being able to select different levels of punishment of an unfair violator's decisions. We replicated previous findings and showed the amplitude of the MFN correlated with the intensity of TPP (Fz, r = -0.516, p = 0.034, FCz, r = -0.509; p = 0.037). Overall, our findings further support the direct link between the MFN and the intensity of TPP., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

More than a decade of neuroimaging and brain stimulation studies point to a crucial role for the right dorsolateral prefrontal cortex (rDLPFC) in prosocial behavior. The intuitive prosociality model postulates that the rDLPFC controls intuitive prosocial behavior, whereas the reflective model assumes that the rDLPFC controls selfish impulses during prosocial behavior. The intuitive prosociality model implies that the transient disruption of the rDLPFC should increase voluntary transfers in both dictator and generosity games. In contrast, the reflective model suggests that the transient disruption of the rDLPFC should decrease transfers in the dictator game, without affecting voluntary transfers in the generosity game, in which selfish motives are minimized. The aim of this paper was to compare predictions of the intuitive and reflective models using the classic dictator game and generosity game and continuous theta burst stimulation (cTBS). In this study, two groups of healthy participants (dictators) received either cTBS over the rDLPFC or right extrastriate visual areas. As shown by the results, the transient disruption of the rDLPFC significantly promoted prosocial motives in the dictator game only, particularly in the trials with the lowest dictator's costs. These findings partially support the notion that the rDLPFC controls intuitive prosocial behavior., (© 2021. The Author(s).)

For over a decade, neuroimaging and brain stimulation studies have investigated neural mechanisms of third-party punishment, a key instrument for social norms enforcement. However, the neural dynamics underlying these mechanisms are still unclear. Previous electroencephalographic studies on third-party punishment have shown that inter-brain connectivity is linked to punishment behavior. However, no clear evidence was provided regarding whether the effect of inter-brain connectivity on third-party punishment is mediated by local neuronal states. In this study, we further investigate whether resting-state neuronal activity in the alpha frequency range can predict individual differences in third-party punishment. More specifically, we show that the global resting-state connectivity between the right dorsolateral prefrontal and right temporo-parietal regions is negatively correlated with the level of third-party punishment. Additionally, individuals with stronger local resting-state long-range temporal correlations in the right temporo-parietal cortices demonstrated a lower level of third-party punishment. Thus, our results further support the idea that global and local neuronal dynamics can contribute to individual differences in third-party punishment., Competing Interests: Conflicts of interest disclosure Declarations of interest: none., (Copyright © 2021 IBRO. Published by Elsevier Ltd. All rights reserved.)

Confidence in our retrieved memories, that is, retrospective confidence, is a metamemory process we perform daily. There is an abundance of applied research focusing on the metamemory judgments and very diverse studies including a wide range of clinical populations. However, the neural correlates that support its functioning are not well defined impeding the implementation of noninvasive neuromodulatory clinical interventions. To address the neural basis of metamemory judgments, we ran a meta-analysis, where we used the activation likelihood estimation method on the 19 eligible functional magnetic resonance imaging studies. The main analysis of retrospective confidence revealed concordant bilateral activation in the parahippocampal gyrus, left middle frontal gyrus, and right amygdala. We also run an analysis between the two extreme levels of confidence, namely, high and low. This additional analysis was exploratory, since the minimum amount of articles reporting these two levels was not reached. Activations for the exploratory high > low confidence subtraction analysis were the same as observed in the main analysis on retrospective confidence, whereas the exploratory low > high subtraction showed distinctive activations of the right precuneus. The involvement of the right precuneus emphasizes its role in the evaluation of low confidence memories, as suggested by previous studies. Overall, our study contributes to a better understanding of the specific brain structures involved in confidence evaluations. Better understanding of the neural basis of metamemory might eventually lead to designing more precise neuromodulatory interventions, significantly improving treatment of patients suffering from metamemory problems., (© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)

Many studies suggest that social punishment is beneficial for cooperation and consequently maintaining the social norms in society. Neuroimaging and brain stimulation studies show that the brain regions which respond to violations of social norms, the understanding of the mind of others and the executive functions, are involved during social punishment. Despite the rising number of studies on social punishment, the concordant map of activations - the set of key regions responsible for the general brain response to social punishment - is still unknown. By using coordinate-based fMRI meta-analysis, the present study examined the concordant map of neural activations associated with various social punishment tasks. A total of 17 articles with 18 contrasts including 383 participants, equalling 191 foci were included in activation likelihood estimation (ALE) analysis. The majority of the studies (61%) employed the widely used neuroeconomic paradigms, such as fairness-related norm tasks (Ultimatum Game, third-party punishment game), while the remaining tasks reported criminal scenarios evaluation and social rejection tasks. The analysis revealed concordant activation in the bilateral claustrum, right interior frontal and left superior frontal gyri. This study provides an integrative view on brain responses to social punishment.

Identifying facial expressions is crucial for social interactions. Functional neuroimaging studies show that a set of brain areas, such as the fusiform gyrus and amygdala, become active when viewing emotional facial expressions. The majority of functional magnetic resonance imaging (fMRI) studies investigating face perception typically employ static images of faces. However, studies that use dynamic facial expressions (e.g., videos) are accumulating and suggest that a dynamic presentation may be more sensitive and ecologically valid for investigating faces. By using quantitative fMRI meta-analysis the present study examined concordance of brain regions associated with viewing dynamic facial expressions. We analyzed data from 216 participants that participated in 14 studies, which reported coordinates for 28 experiments. Our analysis revealed bilateral fusiform and middle temporal gyri, left amygdala, left declive of the cerebellum and the right inferior frontal gyrus. These regions are discussed in terms of their relation to models of face processing.

Social norms have a critical role in everyday decision-making, as frequent interaction with others regulates our behavior. Neuroimaging studies show that social-based and fairness-related decision-making activates an inconsistent set of areas, which sometimes includes the anterior insula, anterior cingulate cortex, and others lateral prefrontal cortices. Social-based decision-making is complex and variability in findings may be driven by socio-cognitive activities related to social norms. To distinguish among social-cognitive activities related to social norms, we identified 36 eligible articles in the functional magnetic resonance imaging (fMRI) literature, which we separate into two categories (a) social norm representation and (b) norm violations. The majority of original articles (>60%) used tasks associated with fairness norms and decision-making, such as ultimatum game, dictator game, or prisoner's dilemma; the rest used tasks associated to violation of moral norms, such as scenarios and sentences of moral depravity ratings. Using quantitative meta-analyses, we report common and distinct brain areas that show concordance as a function of category. Specifically, concordance in ventromedial prefrontal regions is distinct to social norm representation processing, whereas concordance in right insula, dorsolateral prefrontal, and dorsal cingulate cortices is distinct to norm violation processing. We propose a neurocognitive model of social norms for healthy adults, which could help guide future research in social norm compliance and mechanisms of its enforcement., (© 2017 Wiley Periodicals, Inc.)

Objective: Decision-making in the Iowa Gambling Task (IGT) has been intensively studied regarding both the "hot" and "cold" components. The ventromedial prefrontal cortex is a key region involved in processing somatic marker information, though recent findings suggest dorsolateral regions are also important. The dorsolateral prefrontal cortex is also known as a substrate of executive functions-the cold component of decision-making. However, there is contradictory evidence about the role of executive functions, as well as the hot component of decision-making-emotional intelligence. Previous findings suggest that patients with right frontal lobe lesions find decision-making more problematic in IGT. The goal of this study is to replicate previous findings on IGT performance in patients with dorsolateral lesions compared to controls., Methods: We obtained data from patients with right frontal lobe tumors (n = 12), localized in the dorsolateral prefrontal cortex, and healthy controls (n = 21) who undertook the IGT, Wisconsin Card Sorting Test (WCST), Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT), and D-KEFS Color-Word Interference Test., Results: The performance in the IGT, WCST, and EI tests is impaired in the clinical group. At the subgroup level, we found patients had lower EI scores regarding the ability to use "emotions for thinking facilitation". However, we found an interaction between the EI scores regarding the ability "the perception and identification of emotions" and the performance on WCST only in the patient group., Conclusion: This study raises the possibility of identifying components of EI which could be helpful in understanding the impairment of patients with right dorsolateral lesions., (© The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)