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The right to own property is an intrinsic human right that grants ownership and enjoyment to owners. The property right, however, is not absolute because it is subject to the state’s authority to compulsorily acquire land that is in private hands, which is referred to as land acquisition. Land acquisition refers to the power granted to the state government to obtain privately owned land for a public purpose, in exchange for fair compensation (Keith et al., 2008). Land acquisition is an essential strategy for the state to address the limited availability of land when it is necessary to create railways, airports, or any other infrastructure for the benefit of the public (Jonathan, 2012). Nevertheless, the process of acquiring land is a lengthy procedure that has a significant influence on the local community. This is because it involves conflicting interests between the government that is seemingly acting on behalf of the general public, and the very public who are affected by the acquisition itself. Therefore, the land acquisition system is supposed to be designed as a method of reconciling these conflicting interests. Despite this ideal purpose, numerous countries, particularly in emerging nations like Malaysia, face challenges in achieving a harmonious equilibrium between the conflicting public and private interests. These challenges arise from inadequate legislative safeguards and a conventional hierarchical approach adopted by the government branches of the state (Ghimire et al., 2017). The public aspect is usually legally defined, but private perspectives may not always be apparent. In order to achieve the right balance between conflicting public and private interests, this study aims to examine the perspectives of the individuals, i.e., the landowners who are directly affected by the land acquisition. This study examines their perceptions and attitudes towards the whole process and procedures of the land acquisition to which they were subjected, as well as their corresponding responses and willingness to make sacrifices in pursuit of the higher objectives of the state. To achieve this goal, a questionnaire survey has been used as the methodology of collecting data from the landowners and the results are presented using descriptive analysis. The outcome demonstrated that whenever the state exercises the power of land acquisition, the balance tends to side with the interest of the public rather than the private interests of the affected individuals, both in law and in practice. In addition, Malaysia became a member of the United Nations on 17 September 1957. Hence, it is crucial to examine the principles of compulsory land acquisition as delineated by the United Nations study (Keith et al., 2008). The final section of this article provides an analysis of the findings and then make recommendations by referring to Australia’s best practices for adoption in Peninsular Malaysia. The methodologies employed in this study are the data collection method and comparative legal analysis.

The signed pressure force (SPF) function has recently become a popular function for guiding the curve evolution of the active contour model (ACM) for image segmentation. The aim is to extract the boundaries of digital medical images for shape and image analysis. The recent SPF-based ACM demonstrates effectiveness in image segmentation. However, it may fail if the targeted object is close to a neighbouring object. Additionally, the presence of intensity inhomogeneity and noise in medical images degrades segmentation accuracy and local target areas. Thus, we proposed a new SPF-based ACM, namely the Selective Segmentation with Signed Pressure Force 1 (SSPF1) model, by incorporating the ideas of the SPF function and the distance fitting term based on geometrical constraints. Then, the new SSPF1 model was extended by incorporating an image enhancement technique to develop our second new model, termed the Selective Segmentation with Signed Pressure Force 2 (SSPF2). Numerical results indicated that the SSPF2 model was more recommended than SSPF1 as the SSPF2 model was approximately 4.7% more accurate, as indicated by the Jaccard value and was about 112 times faster in segmenting noisy images compared to the existing selective segmentation model.

A monophage herbivorous insect called S. pectinicornis can be utilized to biologically control the weed Pistia stratiotes. Insect mass reproduction followed by release into the target weed area is one technique that can be used. The quality of the feed must be taken into consideration during maintenance in order to increase the fitness of S. pectinicornis insects and enable them to function at their best. The fertilization procedure can improve the nutritional value of P. stratiotes as a feed source. The experiment involved applying NPK fertilizer to P. stratiotes at 6 different levels: 0 g (control); 5 g; 10 g; 15 g; 20 g; and 25 g. The findings demonstrated that when NPK fertilizer was applied to Pistia stratiotes, S. pectiniconis larvae, pupae, and imago had a better chance of surviving than controls. S. pectinicornis showed improved insect growth and development since its lifespan was shorter than controls at every developmental stage. The ideal NPK fertilizer dose for maintaining Pistia stratiotes as feed during S. pectinicornis propagation is 15g/20 L of water.

Abstract: Increase in fatalities among cancer patients is one of untreated facts and today cancer remains one of the main health issues. The most common cause of cancer death is lung cancer. Rhodanine has been recognized as a privileged scaffold in medicinal chemistry due to its well-known ability to demonstrate a broad range of biological activities, and most of its derivatives exhibited remarkable anticancer activity in the (μg/mL) concentration range, while causing negligible cytotoxicity to normal cells. New N- and 5- disubstituted aminorhodanine derivatives were synthesized by Schiff base and Knoevenagel condensation reactions over two consecutive steps. Human cancer cells and Hdfn (human dermal fibroblasts isolated from neonatal foreskin) cells line, were used to evaluate the synthesized compounds’ activity by MTT assay. The new compounds revealed higher anticancer activity against A549 lung cells cancer when compared with reference drug Erlotinib (anticancer drug) and determined no toxicity or safety on normal cell. Among the tested compounds, 2b2 compound show potent anticancer activity which have IC50 about (55.8 μg/mL).

The study showed the repellent effect of three types of plant powders, Mentha, Myrtus and Ocimum basilica, against rice weevil Sitophilus oryzae (L.) (Coleoptera: Curculionidae), the results of the study showed that the Myrtus powder had the highest rate of repellent to insects. It reached the highest percentage of repellent outside the loop within 24 hours 41% at concentration of 6% where it was found that there was a significant difference in percentage compared to other plant powders (Mentha, Ocimum basilica) reached 39.5% and 37.5 %, respectively.

Integrating ceramic and metallic properties in MAX phases makes them highly desirable for diverse technological applications. In this study, through first-principles density functional theory (DFT), we investigated the physical properties of two new 312 MAX compounds, M3GaB2 (M = Ti, Hf). Chemical stability is confirmed via formation energy assessment, while mechanical stability is established by determining elastic stiffness constants. A thorough analysis of mechanical behaviors includes bulk modulus, shear modulus, Young's modulus, and hardness parameters. M3GaB2 demonstrates elastic constants and moduli closely aligned with other 312 carbides. Understanding the electronic band structure and density of states (DOS) sheds light on metallic properties, with anisotropy in electrical conductivity clarified through energy dispersion analysis. Investigation of photon interaction with titled compounds, including dielectric constants (real and imaginary parts), refractive index, absorption coefficient, photoconductivity, reflectivity, and energy loss function, has been carried out. The potential of M3GaB2 borides as a coating to reduce solar is evaluated based on the reflectivity spectra. These findings deepen our understanding of material properties and suggest diverse applications for M3GaB2 in various technological domains.

Background: Molluscum contagiosum virus (MCV) is a viral cutaneous infection that occasionally affects the mucous membrane and skin, mainly among children and young adults, occurring worldwide. MCV is a double-stranded DNA virus that belongs to the poxvirus family. The prevalence of MCV in Iraq and its frequency are mostly unknown, despite the virus being transmissible directly from person to person, with several significant outbreaks reported in recent years. This study represents the first investigation of MCV in the province of Al-Qadisiyah. Utilizing real-time PCR and histopathological examination, the research aimed to validate the clinical diagnosis of MCV. The study involved the histological examination of Molluscum contagiosum and compared it with real-time PCR analysis of MCV. Methods: The study was conducted from October 1, 2022, to March 30, 2023. Lesion samples were taken from 80 patients initially. The disease had spread widely and quickly in the city, affecting individuals aged between 1 and 2 years who had been diagnosed with clinical lesions of MCV on various body areas. Non-random (purposive) samples were collected for the study. Results: Following real-time PCR testing and histological examination (90 %), patients yielded positive results for Molluscum contagiosum virus (MCV), aligning with clinical diagnosis. Histopathological analysis revealed distinctive cytopathic effects and localized hyperplasia in epidermal keratinocytes indicative of Molluscum contagiosum. No significant disparity was observed between MCV infection and sex or age. Additionally, histological examination identified 8 (10 %) patients infected with human papillomaviruses. Conclusion: The present comprehension regarding the epidemiology and prevalence of MCV in Iraq remains limited. The findings highlight a significant rise in MCV infections compared to other infectious skin diseases, underscoring the urgency for further investigation to mitigate the risk of a potential global epidemic.

Geopolymer concept is by using industrial waste materials which is rich in silica and alumina, then activating them with alkaline solution. An appropriate binder combination that achieves high early age strength at ambient temperature using FA is still subject required. Thus, this study has been designed in two stages which involving the paste and mortar studies. The alkaline activator as a blend of sodium hydroxide and sodium silicate solution with SS/SH ratio of 2.5, NaOH molarity of 12 M and L/B ratio of 0.43 are used for geopolymer composite. Compressive strength, water absorption and shrinkage are tested on geopolymer mortar with various level of blended combination. High volume content (60–80 %) gave a promising early age compressive strength at ambient temperature. Metakaolin gave a further strength improvement on geopolymer mortar. Overall, the finding suggested that the geopolymer with high FA content is suitable for cement-based material repair product.

Activated carbon (AC) supported catalysts have been extensively applied as deoxygenation (DO) catalysts. However, the details of in situ experimental investigations that relevant to this catalyst are limited. Hereby, we present a series of operando/in situ spectroscopic experiments for DO of waste sludge palm oil (WSPO) by using atomically dispersed La-W bimetallic supported AC catalysts (La-W/AC) with well-defined structures. The La(5%)-W(2%)/AC catalyst prepared through co-precipitation (CP) process rendered high surface area (741 m2/g) and catalyst’s acidity (13319.16 µmol/g). Besides, the catalyst demonstrated a superior catalytic performance of DO reactivity under optimal reaction conditions of 0.5 % catalyst loading (CL), a one hour reaction time (Rt), and 250 °C reaction temperature (RT), achieving 98 % WSPO conversion to green fuel turnover frequency (TOF) of 0.0153 s-1. The reusability of La(5%)-W(2%)/AC catalyst was positively active for eight runs of DO process with constant of conversion rate at > 87 %. In addition, DO mechanism was of WSPO model compound (palmitic acid) was conducted to gain the clearer insight of reaction pathway catalysed by La-W/C catalyst. In situ FTIR analysis confirms the presence of intermediates (e.g. n-heptadecane, n-pentadecane, n-nonane, n-tridecane, and trimethylcyclopentene) that attributed buy the acid site of the heteropoly acid support. Besides, in situ XAS spectroscopy consolidates the oxidation state of La and W, where the presence of metal centre, support and substrate were confirmed to reflect the occurrence of palmitic acid DO on atomically dispersed La and W active sites. Thus, the present findings identified several key product intermediates during DO process, as well as the stable-state of catalyst structure, which suggest that the atomically dispersed La(5%)-W(2%)/AC catalysed reactions follow an unconventional decarboxylation/decarbonylation reaction pathways with the activation of oxygen (O2) removing is rate limiting.

Kecenderungan inferioritas generasi muda semakin meningkat, ditandai dengan kekurangpercayaan diri terhadap budayanya sendiri. Pergaulan dan life style juga mengarah pada sikap individualis, materialis, hedonis, menggejolaknya politik identitas dan tidak jarang menujukkan pada perilaku yang amoral lainnya. Selain itu juga muncul pada konteks kebangsaan Indonesia yang mengakomodir pluralitas tersebut, tidak jarang memicu konflik dan perpecahan ditandai dengan muncul kelompok-kelompok kontra-Pancasila dengan dalih tidak sesuai dengan paham keagamaan yang dianut. Pesantren menjadi lembaga pendidikan Islam yang dinilai mampu membentuk santri dilandasi dengan nilai moralitas. Kegiatan Pengabdian kepada Masyarakat ini bertujuan untuk memberikan pendampingan dan penguatan nilai-nilai ideologi kebangsaan (Pancasila) kepada santri di Pesantren Mahasiswa An Najah Purwokerto melalui program Sekolah Pancasila. Metode pelaksanaa PkM ini meliputi tahap persiapan yaitu workshop kerja dan studi literatur, tahap pelakansaanya meliputi studi dokumen, workshop, studi meja, FGD dan Sekolah Pancasila dan terakhir adalah tahap pelaporan. Adapun program pengabdian ini adalah untuk menguatkan nilai-nilai ideologi kebangsaan pada santri di Pesantren Mahasiswa An Najah Purwokerto, sehingga memberikan penguatan santri dalam memahami dan menghayati nilai-nilai Pancasila sehingga dapat menjadi dasar dalam pola pikir dan berperilaku di dalam realitas kehidupan masyarakat yang beragam.

Background Physical restraints (PRs) are frequently used in adult critical care units to protect staff and prevent self-harm, despite the fact that they represent significant safety risks. Restraint complications may have an impact on the patient’s long- and short-term outcomes. This integrative review aimed to meticulously evaluate existing evidence pertaining to physical restraint practices in adult critical care settings. The review was specifically geared towards examining the prevalence of PR, identifying influential factors, elucidating the role of nurses in PR implementation, exploring nurses’ experiences in caring for patients under restraint, and scrutinizing the complications associated with PR application Method This integrative review included the studies published between January 2009 and December 2019 and the literature search was conducted in July 2020. The databases searched included EBSCOhost, Ovid, ProQuest, PubMed, Wiley Online Library, SCOPUS, and ScienceDirect. The keywords included in the search were restraint, critical care, intensive care, ICU, mechanical ventilation, intubation, nursing, and experience. A checklist based on the CASP checklist and the JBI Critical Appraisal Tool was used to assess the methodological quality. Results The findings were evaluated and summarized into seven key topics after twenty-one publications were found to be evaluated. i) High prevalence of PR application in adult critical care unit; ii) determinants of PR applications; iii) types of PR in adult critical care units; iv) decision maker of PR; v) moral and ethical dilemma in PR application; vi) awareness and guidelines for PR applications; vii) common complications and use of sedation, analgesics, antipsychotic drugs in PR application. Conclusion The number of days PR is used is related to the risk of an adverse event. In order to standardize nursing practice, ICU nurses require greater training on the ideas of PR use. Evidence-based recommendations will assist critical care nurses in making the best judgments possible concerning the use of PR.

This research offers an extensive study of different machine learning issues for predictive maintenance applications for motor condition ranging from AC motors. The research establishes a scenario that represents the real world to identify which algorithms can be trusted to predict both the time of failure and the actual type of failure in the AC motors. The employed machine learning algorithms include the Random Forest (RFC), Support Vector Classifier (SVC), K-Nearest Neighbor (KNN), Logistic Regression (LR), and XGBoost (XGB) in our work. The assessment includes the comparison of algorithms in terms of the predictive accuracy educated with different size training data. Before the model is developed, thorough data preprocessing methods will be applied that will allow the breaking down of the model assumptions and the optimization of the performance. For preprocessing step the following two steps are made including the removal of unclear samples, label encoding used for categorical columns, and column scaling. Intriguingly, the identification of seemingly outlier data points is revisited, revealing their integral role in capturing the natural variance of the dataset and enhancing classification tasks. These identified features are observed to be pivotal contributors to predictive models. The study shows that in both algorithm failure cases and failure type identification, their performances are comparable. Regarding training time, K-Nearest Neighbors (KNN) algorithm yields the top-performing model for both datasets ( 4 sec and 3 sec) respectively, whereas Random Forest (RFC) performs the worst training time (151 sec) which belong to the binary failure prediction task and XGBoost (XGB) in multi-class failure prediction task (276 sec), which is contributed. Finally, this paper emphasizes that deciding on which machine learning model is appropriate for predictive maintenance can be quite a challenge due to the necessity to balance between accuracy and training time. The findings constitute important tipping point for those companies that aim to implement a solution for predictive maintenance with the KNN model being faster and efficient at the same time.

Solanum nigrum is known locally as the nightshadesamily, and it is considered one of the widespread plants that possess great biochemical potential. This review dealt with providing a comprehensive summary of the biochemistry of this plant, as it contains Solanum nigrum. It contains an important group of biologically active substances, including flavonoids, and some phenolic derivatives. It also contains some alkaloids, epoxy derivatives, and other important compounds. These substances have important biological activity, including significant and powerful antioxidant and anti-inflammatory properties, as well as strong antimicrobial and anti-cancer properties, and other medically important properties. This plant has been used for medicinal purposes for a long time in treating many diseases. Finally, this review indicates the wide biological diversity in biochemistry. The study also touched on some potential applications in various fields, including nutrition and medicine.

This study showed all isolates of bacteria are identified by many testes , such as morphological, biochemical, and API20E testes, as, the results confirmed that the Gram-negative bacteria in Thi-Qar government during the period of June and July 2023-2024. A total of 60 non-duplicate urine samples from patients are collected and examined for detection of Gram-negative bacteria. The results show that out of 60 urine samples 35(58.33%) samples are positive for bacterial growth of Gram negative. The results of bacterial diagnosis depending on testing showed that the frequency of bacterial pathogens thatause UTI as the following 15 (42.85%) are Escherichia coli,7 (20.0%) Enterobacter cloacae, 5 (14.28%) Klebsiella pneumonia, 3 (8.57 %) are from each of Proteus mirabilis and Pseudomonas aeruginosa, and 2 (4.76%) are Citrobacter spp. Antibiotics were divided into three categories that work on (nucleic acid, protein inhibition ,and bacterial cell wall synthesis) and the three groups were compared with each other .It was concluded which of them was more effective and performed better in eliminating bacteria and the results appeared as follows: Gram negative bacteria showed 91.42 % resistance to ampicillin 85.7% resistance to amikacin, 65.71% resistance to levofloxacin, 45.71% resistance to Norfloxacin, 31.42 % resistance to azithromycin and 13.37% resistance to ciprofloxacin.

Beta thalassemia (β-thalassemia) is the most severe kind of β-thalassemia hereditary disease that makes blood transfusion dependent. Patients with β-thalassemia disease experience many physiological abnormalities, including oxidative stress, iron overload, and aggregated β-globin proteins. These abnormalities may also lead to premature RBC mortality. In the present study, 100 patients with β-thalassemia major with an average age of 16.30 ± 6.67 years old and 30 healthy controls with an average age of 14.63 ± 4.17 years old were included in this study. The serum levels of urea, creatinine, serotonin, and cortisol were investigated in the patient and control groups. The results showed a marked increase in the urea levels among the patients compared to the control group (from 14.63 ± 6.05 mg/dl in the control group to 24.98 ± 11.35 mg/dl in patient group) with P

The COVID-19 pandemic has led to a search for effective pharmaceuticals and vitamins to combat the virus. These therapies have antiviral capabilities and can affect both gram-negative and gram-positive bacteria. This study aims to assess the effectiveness of various medications and nutrients in treating bacterial infections linked to COVID-19. In vitro, tests will be conducted to evaluate these therapies' antibacterial efficacy against both gram-negative and gram-positive bacteria. In the current study, we test a group of antibiotics commonly used in treating Coronavirus on different types of Gram-positive and Gram-negative bacteria. They found that Azithromycin was highly effective against both positive and negative bacteria, but its effectiveness decreased when combined with vitamin D. Levofloxacin was the most effective antibiotic, and its efficacy was not affected by the addition of zinc or vitamin D. Acyclovir had a slight effect on bacteria when used alone, but its efficacy improved with zinc. Zinc and Vitamin D had a high degree of effectiveness, but Vitamin D had relatively low efficacy, except against one type of bacteria. The study aims to evaluate the effectiveness of drugs and vitamins against bacterial infections in COVID-19 patients. The results will provide a better understanding of the potential advantages of these medications in controlling bacterial infections. (The abstract should have one paragraph) The study aims to evaluate the effectiveness of drugs and vitamins against bacterial infections in COVID-19 patients. The results will provide a better understanding of the potential advantages of these medications in controlling bacterial infections.

Abstract Introduction Major depressive disorder (MDD) is associated with dysfunctional reward processing, which involves functional circuitry of the habenula (Hb) and nucleus accumbens (NAc). Since ketamine elicits rapid antidepressant and antianhedonic effects in MDD, this study sought to investigate how serial ketamine infusion (SKI) treatment modulates static and dynamic functional connectivity (FC) in Hb and NAc functional networks. Methods MDD participants (n = 58, mean age = 40.7 years, female = 28) received four ketamine infusions (0.5 mg/kg) 2−3 times weekly. Resting‐state functional magnetic resonance imaging (fMRI) scans and clinical assessments were collected at baseline and 24 h post‐SKI. Static FC (sFC) and dynamic FC variability (dFCv) were calculated from left and right Hb and NAc seeds to all other brain regions. Changes in FC pre‐to‐post SKI, and correlations with changes with mood and anhedonia were examined. Comparisons of FC between patients and healthy controls (HC) at baseline (n = 55, mean age = 32.6, female = 31), and between HC assessed twice (n = 16) were conducted as follow‐up analyses. Results Following SKI, significant increases in left Hb‐bilateral visual cortex FC, decreases in left Hb‐left inferior parietal cortex FC, and decreases in left NAc‐right cerebellum FC occurred. Decreased dFCv between left Hb and right precuneus and visual cortex, and decreased dFCv between right NAc and right visual cortex both significantly correlated with improvements in mood ratings. Decreased FC between left Hb and bilateral visual/parietal cortices as well as increased FC between left NAc and right visual/parietal cortices both significantly correlated with improvements in anhedonia. No differences were observed between HC at baseline or over time. Conclusion Subanesthetic ketamine modulates functional pathways linking the Hb and NAc with visual, parietal, and cerebellar regions in MDD. Overlapping effects between Hb and NAc functional systems were associated with ketamine's therapeutic response.

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background: This study aimed to evaluate the effect of bioactive composite (ACTIVA) on enamel demineralisation when used as an orthodontic adhesive, compared to other adhesives. Materials and methods: Human upper premolars (n=64) were randomly divided into two equal groups; the first group stored the bonded teeth in deionised water for 30 days at 37°C, and the second group exposed the bonded teeth to acidic media. Each group was further subdivided into four subgroups, with eight premolars in each subgroup, based on the type of adhesive used to bond metal brackets: non-fluoride-releasing adhesive (Transbond XT), fluoride-releasing adhesive (Light Bond), light-cured, resin-reinforced glass ionomer (GC Fuji ortho LC), and bioactive restorative composite (ACTIVA BioACTIVE-RESTORATIVE). Enamel demineralisation was assessed at baseline and after 30 days with a laser fluorescence device (DIAGNOdent™ Pen). Results: There were significant differences in fluorescence variation values (ΔFV) among all four tested adhesive systems in both water and acid groups after 30 days. Light Bond adhesive showed the highest fluorescence variation value, while glass ionomer showed the lowest, indicating less enamel demineralisation around the bracket. ACTIVA had less enamel demineralisation in acidic media. However, there was no significant difference in enamel demineralisation between water storage and acidic media groups. Conclusion: ACTIVA (RMGIC + composite) exhibited less enamel demineralisation than Light Bond; however, Fuji ortho LC showed the lowest enamel demineralisation.

BackgroundSpinal cord injury (SCI) is a devastating condition that often leads to significant impairments in physical function, leading to disability and mental health disorders. Hence, understanding the prevalence of SCI and the relationship between physical activity and mental health in individuals with SCI is crucial for informing rehabilitation strategies and optimizing outcomes. ObjectiveThis study aims to comprehensively analyze existing research on the link between physical activity and mental health and identify the level of physical activity and mental health status, the barriers to physical activity, and SCI’s impacts on psychological well-being in individuals with SCI. MethodsAn electronic search strategy will be used to identify prevalence studies published since 1993 in health-related databases such as PubMed, MEDLINE, COCHRANE Library, and Wiley Library using the following query: “Spinal Cord Injury” OR “Paraplegia” OR “Tetraplegia” AND “Physical Activity” OR “Exercise” AND “Mental Health” OR “Mental Illness” OR “Mental Disorder.” Bibliographies of primary studies and review articles meeting the inclusion criteria will be searched manually to identify further eligible studies. The risk of bias in the included studies will be appraised using the Joanna Briggs Institute checklist for prevalence studies by 2 review authors. Any disagreement will be resolved by reaching a consensus. ResultsFunding was received in October 2023, data collection will commence in July 2024, and the results are expected by 2025. We will summarize the selection of the eligible studies using a flowchart. The data from the studies will be extracted and tabulated. This scoping review will be published in a peer-reviewed journal in accordance with PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guidelines. ConclusionsThis scoping review underscores the complex relationship between physical activity and mental health among individuals with SCI, highlighting the level of physical activity and mental health status, barriers to physical activity engagement, and psychological implications. Understanding these dynamics is crucial in devising tailored interventions aimed at enhancing mental well-being. This synthesis of evidence emphasizes the need for personalized strategies to promote physical activity, addressing unique challenges faced by this population to foster improved mental health outcomes and overall quality of life. Trial RegistrationOpen Science Framework osf.io/ugx7d; https://osf.io/ugx7d/ International Registered Report Identifier (IRRID)PRR1-10.2196/56081

Garlic (Allium sativum L.) is a widely abundant spice, known for its aroma and pungent flavor. It contains several bioactive compounds and offers a wide range of health benefits to humans, including those pertaining to nutrition, physiology, and medicine. Therefore, garlic is considered as one of the most effective disease-preventive diets. Many in vitro and in vivo studies have reported the sulfur-containing compounds, allicin and ajoene, for their effective anticancer, anti-diabetic, anti-inflammatory, antioxidant, antimicrobial, immune-boosting, and cardioprotective properties. As a rich natural source of bioactive compounds, including polysaccharides, saponins, tannins, linalool, geraniol, phellandrene, β-phellandrene, ajoene, alliin, S-allyl-mercapto cysteine, and β-phellandrene, garlic has many therapeutic applications and may play a role in drug development against various human diseases. In the current review, garlic and its major bioactive components along with their biological function and mechanisms of action for their role in disease prevention and therapy are discussed.

Objective: Substance use disorder is a growing concern in the USA, especially among pregnant women. This study was undertaken to assess the impact of substance use disorder on adverse pregnancy outcomes using a nationwide sample of inpatient pregnancy hospitalizations in the USA, and to elucidate the influence on each type of adverse pregnancy outcome. Study design: A cross-sectional analysis of inpatient pregnancy hospitalizations in the USA from the Healthcare Cost and Utilization Project National Inpatient Sample from 2016 to 2020 was conducted. International Classification of Diseases – 10th revision and diagnosis-related group codes were used to identify inpatient pregnancy-related delivery hospitalizations with a substance use disorder and/or adverse pregnancy outcomes. Propensity score matching and multiple logistic regression analyses were undertaken to predict the likelihood of adverse pregnancy outcomes among pregnancy hospitalizations with and without substance use disorder. Subgroup analyses were performed to estimate the impact of substance use disorder on each adverse pregnancy outcome. Results: From 3,238,558 hospitalizations, the prevalence of adverse pregnancy outcomes was substantially higher among pregnancy hospitalizations with substance use disorder (35.6 %) compared with pregnancy hospitalizations without substance use disorder (25.1 %, p

Background Diphtheria is an acute bacterial infectious disease characterized by serious morbidity and mortality. Outbreaks continue to occur in developing countries despite national vaccination programs. Vaccination, early recognition the disease, and adequate intervention are needed to avoid devastating outcomes. Objective To describe the clinical spectrum of childhood diphtheria and its association to outcomes during the 2019-2020 diphtheria outberak in Yemen. Methods This was a retrospective study to assess the demographic, clinical features, and outcomes of paediatric respiratory diphtheria in patients with diphtheria during the outbreak from September 2019 until May 2020 admitted at Mukalla Maternity and Children Hospital. We used SPSS 22 version for data analysis. Results There were 34 culture-confirmed diphtheria cases included in this study, their age ranged from 13 months to 15 years old. Most of the cases (76.5%) happened to children at more than 5 years old. There was no gender difference. Of these 34-positive diphtheria, 79.4% from Hadramout and 17.6% from Shabwa governorate. Most of the cases (35.3%) were admitted in December. More than half of the patients (52.9%) were unimmunized. Fever, sore throat, and enlarged tonsils were presented in all patients, dysphagia (82.4 %), pseudomembrane (91.7%), bull neck (52.9%), and stridor (8.8%) were also found in some patients. Complications included acute renal failure (20.6%), disseminated intravascular coagulation (DIC), shock (17.6%), and myocarditis (8.8%). Significant poor outcome (P< 0.05) was associated with bull neck, myocarditis, acute renal failure, DIC, and shock. The case fatality rate (CFR) was 20.6%. Conclusion Fever, sore throat, tonsillitis, pseudomembrane, and bull neck are high index suspicion of diphtheria and anticipation of ominous outcome. The shifting of occurrence of diphtheria to older age group indicates the need for booster(s) diphtheria toxoid vaccine in addition to improving and strengthening the current immunization program.

Abstract Introduction Waterpipe smoking (WPS) has been associated with a variety of adverse health effects, consequences, and symptoms of nicotine dependence. This study aims to determine the prevalence of WPS dependence among Palestinian university waterpipe smoking students, their normative beliefs about WPS, and their relationship to dependence. Methods A cross-sectional study of current WPS university students at five major Palestinian universities was conducted from September to December 2022. Participants were recruited using convenient sampling, and data collection was carried out via an interviewer-administered questionnaire. We assessed students’ WPS dependence using the Lebanese Waterpipe Dependence Scale. We used the Poisson regression model with robust variance to analyze factors independently associated with high WPS dependence. Results The study included 746 current WPS university students. Results revealed a high prevalence of WPS dependence, with 69.4% (95%CI: 66.0-72.7%) exhibiting high dependence. Factors contributing to high WPS dependence included dual cigarette smoking (aPR: 1.18; 95%CI: 1.12–1.25), studying medical sciences (aPR: 1.13; 95%CI: 1.10–1.18), friends’ approval of WPS (aPR: 1.25; 95%CI: 1.17–1.34), daily WPS frequency (aPR: 1.98; 95%CI: 1.39–2.23), spending more than 50% of daily allowance on WPS (aPR: 1.37; 95%CI: 1.10–1.64), and morning WPS sessions (aPR: 1.97; 95%CI: 1.31–2.27). The study highlighted the influence of social factors, such as peers’ approval and perceived prevalence, on WPS dependence. Conclusions WPS dependence is prevalent among university students, and it is associated with morning WPS, dual smoking, and increased WPS frequency. Notably, peer and cultural factors are essential primary motivators. As a result, it is critical to incorporate WPS considerations into Palestine’s antismoking health promotion program. Therefore, it is vital to incorporate WPS into the Palestinian antismoking health promotion policy, and the health education of adolescents regarding the dangers of WPS should coincide with antismoking initiatives.

The Gulneri Formation (Early-Middle Turonian) Deep-water depositional model was constructed using detailed microfacies analysis from the northern Iraqi wells of Kirkuk (K-116) and Bai Hassan (BH-81) as well as the Dokan outcropped area. In the outcropped section, the formation consists of 2 m of thin friable marly limestone with high organic matter and thin-bedded black shale in addition to boulder and gravel-like limestone masses in the lower part. In the K-116 and BH-81 wells, the formation is 4.3 m and 9 m thick, respectively. It is composed mainly of black bituminous, pyritic calcareous shale, and shaley limestone with scattered glauconites. Petrographic studies of seventeen thin sections of the Gulneri rocks reveal that the pelagic/deep marine faunas are the dominant skeletal grain in the micritic groundmass. Three main microfacies were recognized in the studied rocks of the Gulneri Formation, namely lime mudstone, lime wackestone, and lime packstone. However, the latter is absent in the Dokan section. According to their environmental interpretation, these microfacies were grouped into two facies associations (basinal deep water and deep shelf). Based on the results of petrographic and microfacies analyses, it is concluded that the Gulneri Formation was deposited in a basinal deep marine environment with quiet and reducing conditions in the Dokan section and a basinal deep marine environment in the K-116 and BH-81 wells which changed at intervals to a shallower deep shelf setting toward the upper part with semi reducing conditions. The euxinic deep basin that formed at the beginning of the Kurdistan foreland basin's formation was quite anoxic and deeper from the northeast to the relatively shallower basin with semi-reduced conditions towards the southwest. This is how the depositional model of the Gulneri Formation in northern Iraq changed.

Android application development for online knowledge dissemination is urgently needed at this time. This study aims to develop an android application for learning social skills of children with social emotional barriers. The research participants consisted of 10 students, 75 respondents including teachers and parents of students in partner schools from Jakarta, Purwokerto, Pekanbaru, and Banjarmasin. The design of the android application was validated by four educational experts from universities. Data were collected through questionnaires and FGDs, and analyzed descriptively. The results obtained are the android application model "Maritirukan Aku Bisa with interactive features developed in the form of films, games, movements and songs as well as recording media of student activities, themes developed from aspects of social skills such as attention/concentration, expression/emotions, effective communication, and independence. The android application "Maritirukan Aku Bisa" with updates developed in this study is in accordance with the needs of parents and teachers. The material provided is in accordance with the needs and characteristics of children with social-emotional barriers, and can be accessed independently with the assistance of parents at home. This answers the needs of parents, especially in remote areas throughout Indonesia.

This study rigorously explores the linguistic strategies employed by Pakistani universities for identity construction on social media platforms, focusing primarily on X (formerly known as Twitter). Utilizing a robust methodology of corpus-assisted discourse analysis, we scrutinized a substantial dataset comprising 2861 tweets. These were collected from the official X accounts of two leading Pakistani universities, National University of Sciences and Technology (NUST) and Lahore University of Management Sciences (LUMS), during the academic year 2021/2022. Our in-depth analysis uncovered distinctive linguistic patterns, particularly in the use of pronouns and specific multi-word key terms that each university employs to construct its identity. Intriguingly, the linguistic choices made by these institutions were found to significantly shape their digital identities, reflecting both individuality and broader cultural themes. The study augments existing research in the field by offering novel and context-specific insights into the dynamics of identity construction via social media. It underscores the pivotal role language plays in the organizational branding landscape. Furthermore, the findings from this research serve as a valuable resource for informing and refining communication strategies, not only for educational institutions but also for organizations at large that aim to construct and effectively manage their digital identities on social media platforms.

The Fifth generation (5G) wireless communication system aims to provide high bandwidth, high sensitivity, high gain and power capability. Millimeter wave technology then proposed for these demands with various range of features such as higher bandwidth, low interference, and frequency reuse. However, millimeter wave technology has a key disadvantage of high path loss due to small wavelength in the channel of high attenuation coming from the atmosphere, in addition to the very small wavelength that produces an unwanted crosstalk between the transmission lines. Thus, beamforming network and waveguide-based structures such as Nolen matrix was proposed to overcome these problems. The objective of this research is to design a low loss and high-performance Nolen beamforming network based on waveguide technology. Taking in consideration is the advantage of flexible number of beam ports in Nolen matrix using single layer technique. This work aims to design a $3\times 3$ Nolen matrix with main beam directions of 0, 30° and −30° at 26 GHz. The $3\times 3$ Nolen matrix is designed using low loss hollow waveguide single layer technique. Then, the proposed Nolen matrix is fed three-waveguide slotted antenna. The proposed $3\times 3$ Nolen matrix has measured phase differences at port 1 (35.40°), port 2 (156.43°) and port 3 (−93.57°) in the x-y plane. Waveguide slotted antenna has designed at 26 GHz with tilted slots at broad wall of the waveguide structure. This tilted technique has the benefit of increasing the bandwidth up to 50% of FBW. A simulation and measurement using CST software is performed for the proposed antenna. A return loss of −15 dB with wideband of 2.08 GHz are obtained. A gain of 14 dB is observed at broad wall respectively. Waveguide antenna has been integrated with Nolen matrix to build Nolen beamforming; the measured beamforming network has a good return loss of less than - 10 dB with phase error of −8 degree at outputs. Three beams are achieved with beam scanning of $\pm ~30$ degree. The beam from port 1 is radiated in the direction of −26°. The beams from port 2 and port 3 are radiated in the directions of +27° and +6° respectively. Therefore, this beamforming has a greater impact on the mm wave beamforming networks and applications.

Smart grid (SG) has evolved as a recent topic of discussion and research globally, due to the integration of communication and internet in its network. It facilitates the bidirectional flow of information and power making it vulnerable to attacks including denial of service, fault injection, man-in-the-middle, etc. An integral part of the SG, is the advanced metering infrastructure (AMI), which in turn embodies within itself a critical component of SG such as smart meter (SM), utility company (UC), etc. The AMI also exchanging data and electricity within itself, is a gold mine for adversaries. In addition, the smart meter, being a hardware entity, is susceptible to hardware oriented attacks. In this work, a novel authentication scheme, ZEBRA, for the AMI is proposed. ZEBRA utilizes a combination of Ring Oscillator Physical Unclonable Functions (ROPUFs) for authentication and blockchain for traceability in a Zero Trust Architecture (ZTA) to enhance the security of the AMI. The architecture entails a design that allows for the smart meters in the AMI network to be retrofitted with the new hardware and does not require any use of onboard memory. The authentication scheme, itself, is built to function using the Hamming code parity bits of the ROPUF’s response, rather than the direct responses from the ROPUFs. This ensures a higher degree of difficulty towards a malicious actor attempting to hack the device. By combining ROPUFs and blockchain technology for ZTA a maximum security, real-time AMI authentication scheme is realized. The investigation aimed at satisfying the tenets of ZTA laid down by National Institute of Standard and Technology. ROPUF and blockchain have been used individually and together to realize these tenets for sucessful implementation of ZEBRA.

The field programmable gate array (FPGA) supply chain is vulnerable to security issues from untrusted participants involved, resulting in the significant research being conducted in this domain. These challenges include, but are not limited to intellectual property theft, counterfeiting, bitstream tampering, etc. Such FPGAs are not reliable and can lead to significant security threats to users. To combat the distrust in the FPGA supply chain and secure its integrity, we propose a zero trust framework to secure the FPGA supply chain by leveraging blockchain and ring oscillator physical unclonable functions (ROPUFs). The policies for architecture draw inspiration from zero trust tenets outlined by the National Institute of Standards and Technology. To evaluate the successful implementation of the proposed technique, a case study of FPGA supply chain is presented. For this case study, a typical FPGA supply chain is considered which includes all the participants. This scenario is successfully simulated on the Ganache framework provided by Truffle suite. The experiment is performed on Artix 7 Xilinx FPGAs mounted on Nexys 4 Digilent boards. Finally, each tenet of the implemented zero trust architecture is evaluated by discussing an attack scenario, thus demonstrating the efficiency of the proposed zero trust framework to mitigate potential security risks. To the best of our knowledge, the work presented in this paper is the first to include zero trust principles for protecting the FPGA supply chain using blockchain and hardware oriented security.

Time-series classification (TSC) has been widely utilized across various domains, including brain-computer interfaces (BCI) for emotion recognition through electroencephalogram (EEG) signals. However, traditional methods often struggle to capture the complex emotional patterns present in EEG data. Recent advancements in encoding techniques have provided promising avenues for improving emotion recognition. This study introduces asymmetric windowing recurrence plots (AWRP) as a novel encoding technique to efficiently encapsulate the dynamic characteristics of EEG signals into texture-rich image representations. This study systematically compares the impact of conventional thresholded and unthresholded recurrence plots (RP) versus the proposed AWRP in emotion recognition tasks. Empirical validations conducted across benchmark datasets, such as DEAP and SEED, demonstrate that the AWRP method achieves classification accuracies of 99.84% and 99.69%, respectively, outperforming existing state-of-the-art methodologies. This study emphasizes the significance of input formulation, highlighting that richer input textures, as provided by AWRP, significantly enhance emotion recognition performance while ensuring computational memory usage efficiency. These findings have significant implications in the domain of EEG-based emotion recognition and offer a novel perspective that can guide future research.

Abstract Objectives Parenteral nutrition (PN) can be associated with several treatment-related problems (TRPs) and complications in neonatal settings. Thus, understanding the extent and type of these problems and related factors is pivotal to prevent negative consequences of these preparations. Thus, the aim of this study is to assess factors affecting TRPs in neonatal patients receiving PN. Methods This was a retrospective chart review of neonates receiving PN in NICU and other wards. We collected their demographics, and laboratory workup. TRPs related to PN preparations as well as their pharmacotherapy were the primary outcomes. Results Medical charts of 96 neonate were reviewed. The most encountered TRPs related to patients’ pharmacotherapy were the lack of frequent monitoring (34.2%) and low dose (17.5%). For PN-related TPRs, a mismatch between patients’ nutritional needs and PN composition was observed in third of the patients. Statistically significant positive correlations between number of medications during hospital stay and number of reported TRPs [(r = 0.275, p

Chronic pain research, with a specific focus on the brain-derived neurotrophic factor (BDNF), has made impressive progress in the past decade, as evident in the improved research quality and increased publications. To better understand this evolving landscape, a quantitative approach is needed. The main aim of this study is to identify the hotspots and trends of BDNF in chronic pain research. We screened relevant publications from 2013 to 2022 in the Scopus database using specific search subject terms. A total of 401 documents were selected for further analysis. We utilized several tools, including Microsoft Excel, Harzing's Publish or Perish, and VOSViewer, to perform a frequency analysis, citation metrics, and visualization, respectively. Key indicators that were examined included publication growth, keyword analyses, topmost influential articles and journals, networking by countries and co-citation of cited references. Notably, there was a persistent publication growth between 2015 and 2021. “Neuropathic pain” emerged as a prominent keyword in 2018, alongside “microglia” and “depression”. The journal Pain® was the most impactful journal that published BDNF and chronic pain research, while the most influential publications came from open-access reviews and original articles. China was the leading contributor, followed by the United States (US), and maintained a leadership position in the total number of publications and collaborations. In conclusion, this study provides a comprehensive list of the most influential publications on BDNF in chronic pain research, thereby aiding in the understanding of academic concerns, research hotspots, and global trends in this specialized field.

The main issue is that photovoltaic (PV) systems have their power output reduced due to partial shading. Less energy is produced by photovoltaic modules when partial shading causes an imbalance in the levels of irradiation. Array reconfigurations, both static and dynamic, are suggested as a strategy to improve power capture and reduce the impact of partial shading. Furthermore, it is recognized that irradiance fluctuations, snow, ice, and dust are environmental elements that impact the efficiency of PV arrays. Using white shark optimization (WSO), this research introduces a new method for optimizing the power reconfiguration of PV arrays. Minimizing the disparity in row currents and maximizing power production are the main goals of this WSO-based technique. Four different types of shade patterns are considered in the research: short wide (SW), long wide (LW), short narrow (SN), and long narrow (LN). In order to confirm that this method works, we ran simulations in MATLAB-Simulink and compared the outcomes to those of other configurations, such as Total Cross Tied (TCT), Butterfly Optimization Algorithm (BOA), Harris Hawks Optimization (HHO), and Flower Pollination Algorithm (FPA). Simulation results show the effectiveness of the WSO method in enhancing power extraction from the PV array, especially under partial shading conditions. Notably, the WSO method significantly increases the Global Maximum Power (GMP) output across different scenarios: by 26.22% in SW, 18.51% in LW, 10.95% in SN, and 10% in LN. This confirms the ability of this method to improve the PV power generation in diverse operating environments.

Electromyography (EMG) is the process of acquiring electrical signals generated through muscle activity (contraction/relaxation). Surface EMG deliberates the amount of electrical activity in the musculoskeletal system in a non-invasive way. Under specific conditions and during certain motor activities, this signal is substantially associated with muscle strength. These Signals are used as Control Inputs by assistive devices. The study aimed to investigate the EMG parameters of lower limb muscles (rectus femoris and biceps femoris) in healthy individuals and transtibial amputees walking on a treadmill at different speeds (0.55 m/s, 0.83 m/s, and 1.11 m/s). Ten non-amputee and two amputee subjects participated. Findings reveal significant reductions in EMG signals at slower speeds, emphasizing foot stability. The right biceps femoris exhibits the highest signals average, while the right rectus femoris has the lowest for amputees. The male participants’ right biceps femoris muscle showed the greatest signals of average treadmill walking activity at 0,55 m/s (0.0014 V) compared to the amputee individuals’ (0.001 V). At (0,83 m/s), male participants (0.0015 V) outperformed amputee subjects (0.0004 V). At (1,11 m/s), male participants (0.0024 V) outperformed amputee subjects (0.001 V). Male participants consistently outperform amputees across speeds. The study suggests the potential application of findings in rehabilitating transtibial amputees on a treadmill, considering distance and maximum speed with a prosthesis. Overall, slow walking pace impacts EMG signals, providing insights for clinicians developing interventions for amputee rehabilitation.

Purpose: This systematic review is aimed to evaluate in fixed prosthodontics treated teeth, the effect of the BOPT on periodontal health compared to the horizontal preparation technique using a chamfer finishing line or to the baseline. Methods: The electronic databases Cochrane Central Library, PubMed, Scopus, and ScienceDirect were searched based on specific MeSH keywords. The Randomized controlled clinical trials (RCTs) and prospective clinical trials on BOPT printed in English up to July 2022 were selected. Screening, selection, and data extraction were done. The studies were assessed for risk of bias, and descriptive and meta-analyses were performed. Results: Eight studies were included in the systematic review and only three RCTs were involved in the meta-analysis. Two RCTs were assessed as low risk while one has some concerns. were grouped as good, fair, and poor based on NOS. Three of the prospective studies were considered to be of good quality and one study was fair. The meta-analysis revealed no statistically significant difference in the effect of BOPT and chamfer preparation on periodontal health status and success rate (P > 0.05). Conclusions: Considering the limitation of this review, the BOPT is comparable to chamfer preparation and it resulted in an acceptable effect to maintain periodontal health with a high success rate. However, more evidence is required to support these findings.

Biostratigraphy of the Sinjar Formation is investigated in two sections (Dokan and Sinjar) from northeastern and northwestern Iraq, respectively. Two hundred samples from all the limestones and marl that form the main lithological components of the studied sections were collected. The studied limestones and marl are rich in microfossils. Through thin sections, we were able to identify thirty species of benthic foraminifera and fifteen species of other microfossils (coral, algae, mollusca, bryozoa, and echinoids) at Dokan section, and fifty-one species of benthic foraminifera and thirty species of other microfossils at Sinjar section. 3 biozones were distinguished from both sections 1-Biozone A: Kathina sp.- Lockhartia hunti Assemblage zone (SBZ 5) (Dokan section); (Kathina pemavuti - Lockhartia hunti Assemblage zone (Sinjar section), 2- Biozone B: Idalina sinjarica Total Range zone (SBZ 6-7) and 3-Biozone C: Alveolina globosa- Alveolina pasitisilata Concurrent Range Zone (SBZ8-10). These zones indicate the Late Paleocene –Early Eocene age of the Sinjar formation. The biostratigraphic correlations in the studied sections are based on benthic foraminiferal zonations. Showed the correlation comparison between the biostratigraphic zones of the commonly used benthic zonal scheme around the Late Paleocene -Early Eocene in and outside of Iraq. paleoecological studies suggest that the carbonate sedimentation of the Sinjar Formation thrived in 18-25oC, with mesophotic to oligophobic light, under an oligotrophic to mesotrophic middle ramp environment with normal marine to slightly saline and at water depths from 40 - 80 m. Stable isotopic carbon (δ13C) and oxygen (δ18O) data revealed generally hot conditions with high productivity during the deposition of the Sinjar Formation accompanied by an abrupt change in paleoenvironmental conditions across the Paleocene-Eocene contact.

Current wireless communications urgently need to provide huge data rates, high gain and high directivity radiation pattern beams. Therefore, beamforming networks (BFNs) are introduced to provide these needs. Butler matrix (BM) is a type of beamforming network, which can be realized using fixed network circuits and feeds the antenna array. BM at high frequency suffers from components loss and phase error for massive network, especially when it is implemented using common microstrip structures. Different transmission lines such as waveguide and substrate integrated waveguide (SIW) are studied and introduced to realize Butler matrix. SIW structures are good candidate for the implementation of BM due to its property of low loss transmission line which comprises of properties of microstrip and waveguide technology. However, SIW antennas and structures at millimeter waves have unwanted radiation loss coming from the vias holes. In addition, the vias separation distance is dependent on waveguide size, which leads to a more massive beamforming network at 26-GHz. Hence, this thesis is proposing a more size-friendly and optimal SIW antenna beamforming structure to reduce the vias loss and provides higher bandwidth and gain at 26 GHz. The BM components such as 3 dB coupler, 0 dB crossover, and 45-degree phase shifter are designed by implementing metallic vias determination method. Size and distance of vias are the most important factors in determining the coupling ratio and phase shifts at output ports. Hence, the coupler is designed with different vias width and distance to obtain the correct phase and coupling at output ports. Then, the designed coupler is cascaded to form a 0-dB crossover. The phase shifter is designed with alerting vias distance inside the coupling area of SIW structure. The last component in beamforming is the design of SIW slot antenna based on longitude slot distributions. All the components are integrated to form a $4\times4$ BM with four slot antennas attached to BM networks. Microtrip separation feedline used to for coupler, crossover, BM and BFN. The proposed designs are simulated using CST software and fabricated by PCB LPKF ProtoMat printer. The outcomes of wide bandwidth with more than 1-GHz and high directive gain of more than 10-dB for the beamforming network are achieved. The output power of the BM is between −6-dB to −8-dB at all four ports with phase difference error less than 5°. Four directive beams are achieved at beam scanning of −14°, −41°, 40°, and −14° at port 1 to port 4 respectively. Hence, this $4\times4$ -BM with four slot antenna theses have introduced a successful design of an antenna beamforming network based on SIW technology with significant characteristics at 26-GHz.

Abstract Background Necrotic enteritis (NE) is a severe intestinal infection that affects both humans and poultry. It is caused by the bacterium Clostridium perfringens (CP), but the precise mechanisms underlying the disease pathogenesis remain elusive. This study aims to develop an NE broiler chicken model, explore the impact of the microbiome on NE pathogenesis, and study the virulence of CP isolates with different toxin gene combinations. Methods This study established an animal disease model for NE in broiler chickens. The methodology encompassed inducing abrupt protein changes and immunosuppression in the first experiment, and in the second, challenging chickens with CP isolates containing various toxin genes. NE was evaluated through gross and histopathological scoring of the jejunum. Subsequently, jejunal contents were collected from these birds for microbiome analysis via 16S rRNA amplicon sequencing, followed by sequence analysis to investigate microbial diversity and abundance, employing different bioinformatic approaches. Results Our findings reveal that CP infection, combined with an abrupt increase in dietary protein concentration and/or infection with the immunosuppressive variant infectious bursal disease virus (vIBDV), predisposed birds to NE development. We observed a significant decrease (p

This study aims to investigate the relationship between service quality and student intention behaviour in Higher Education Institutions. This research used a correlational method with a quantitative approach. The online questionnaire was distributed to 110 State University of Surabaya students following the cluster random sampling. In this research, data gathered was analyzed using the Pearson Product Moment correlation analysis. The results showed a significant positive correlation between higher education service quality and student intention behavior. The better service quality provided linier withlinearnt intention behavior fobehaviourending and their intention to loyal in in the institutton. This study's findings remind us to improve the quality dimension as a key factor in attracting and retaining students to student education Institutions.

Abstract Spinal dural arteriovenous fistulas account for the majority of spinal vascular malformations. They are typically located in the thoracolumbar region and are diagnosed in the middle-aged and elderly populations. Although spinal dural arteriovenous fistulas have been postulated to be acquired, their exact development remains uncertain. Typically, the arteriovenous shunt is situated close to the spinal nerve root, inside the dura mater, where the blood from the radiculomeningeal artery and radicular vein intermix. Throughout history, there have been multiple classification systems of spinal arteriovenous shunts since 1967. Those were mainly based on the evolution of diagnostic studies as well as the treatment of these lesions. Such classification systems have undergone significant changes over the years. Unlike intracranial dural arteriovenous fistula, spinal dural arteriovenous fistula is progressive in nature. The neurological manifestations, due to venous congestion, tend to be insidious as well as non-specific. These include sensory deficits, such as paresthesia, bilateral and/or unilateral radicular pain affecting the lower limbs, and gait disturbances. Spinal dural arteriovenous fistulas can be suspected on magnetic resonance imaging/magnetic resonance angiography and confirmed by digital subtraction angiography (DSA). The management includes surgery, endovascular therapy, and in selected cases, radiotherapy. The treatment goal of spinal dural arteriovenous fistula is to halt the progression of the disease. The prognosis depends on both the duration of symptoms as well as the clinical condition prior to therapy. The present article comprehensively reviews the pathophysiology, changes in classification systems, natural history, clinical manifestations, radiological features, management, and prognosis.

Metal-organic frameworks (MOFs) are a relatively new class of materials of unique porous structures and exceptional properties. Currently, more than 110,000 types of MOFs have been reported among the countless possibilities. In this study, we have synthesised a novel MOF using zirconium chloride as the metal source and 4,4'-dicarboxy-2,2'-biquinoline (bicinchoninic acid disodium salt) as the linker, which reacted in N,N-Dimethylformamide (DMF) solvent. Three preparation methods were employed to prepare five types of the MOF, and they were compared to optimize the synthesis conditions. The resulting MOFs, named Zr-BADS, were characterised using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), microscopy, and X-ray diffraction (XRD). By incorporating methanol into the preparation solvent, the surface area was increased to 396 m2/g. Additionally, the prepared MOFs exhibited amorphous shapes, with variations in size depending on the synthesis method. This research demonstrates the significance of the preparation method in controlling resulting particles’ properties.

The trend toward environmental sustainability is already gaining traction, and it is becoming more common in developed and developing countries. Consumers are becoming more aware of sustainability's importance and making more conscious choices about the products they purchase. The Malaysian Government is also promoting green technology by offering incentives and subsidies to companies producing eco-friendly products, also known as green products. Additionally, the Government is introducing regulations to reduce the carbon footprint of businesses and industries. On the other hand, the Government has signed the SDGs and is struggling to achieve them by 2030. Consumption and production are the primary focus of the 12th Sustainable Development Goal. A limited number of studies have been conducted to investigate the consumers' intentions toward purchasing green products in the Malaysian context, particularly on SDGs. Green products are available in the open markets in Malaysia, but consumers' behaviors and their intentions toward such products are considered low. This study is therefore conducted with the aim to investigate the level of consumers' intention towards purchasing green products. Using a 7-point Likert, 385 valid responses were collected from respondents in Selangor, Perak, and Johor. The study found that Malaysian consumers have a medium level of intentions when it comes to purchasing green products. This could be due to the fact that green products tend to be more expensive than their non-green counterparts, and many people are not willing to pay the extra cost. Also, there could be various factors influencing consumers' intentions to buy green products, which future studies can investigate.

Abstract Nano-to-micron-sized coal dust can cause coal workers’ pneumoconiosis (CWP), and cutting and drilling are the main coal dust-generating processes. Based on a self-developed simulated coal cutting and drilling dust generation system, the effects of cutting parameters (tooth tip cone angle, impact angle, roller rotary speed, cutting speed) and drilling parameters (drill bit diameter, drilling speed) on the mass concentration distribution, number concentration distribution and fractal dimension of 10 nm – 10 μm coal dust were investigated. Results show that the mass concentration of 10 nm – 10 μm coal dust generated by cutting/drilling peak at 5.7 – 7.2 μm, while the number concentrations during cutting and drilling respectively peak at 60 – 90 nm and 20 – 30 nm. During both cutting and drilling processes, the generated coal dust particles in 10 – 300 nm account for > 90% of the total 10 nm – 10 μm coal particles, while PM2.5 in PM10 is generally below 18%. It is also found that smaller tooth tip cone angle, larger impact angle, lower roller rotary speed, smaller drill bit diameter, or lower drilling speed can reduce the generation of 10 nm – 10 μm coal dust with a fractal dimension of 0.94 – 1.92. This study reveals the distribution characteristics of nano- to micron-sized coal dust particles under different cutting and drilling parameters, and the research results can serve as reference for adjusting cutting and drilling parameters to lower down the 10 nm – 10 μm coal dust generation and thus prevent the CWP.

Hipertensi merupakan masalah kesehatan masyarakat dan menjadi penyebab kematian paling tinggi. Hipertensi mengakibatkan kurang lebih 7,5 juta kematian di seluruh dunia dari 12,8% total kematian keseluruhan. Berdasarkan data Dinas Kesehatan Kabupaten Banjar prevalensi beberapa faktor risiko hipertensi pada masyarakat di Kabupaten Banjar khususnya di wilayah Kecamatan Aluh-Aluh yaitu konsumsi gula berlebih (1,5%), garam berlebih (2,5%), lemak berlebih (1,2%), kurang konsumsi buah dan sayur (3%), merokok (1,2%), obesitas sentral (6,3%), dan obesitas (2,9%) dari total penduduk usia > 15 tahun. Penelitian ini bertujuan untuk menganalisis faktor yang berhubungan dengan kejadian hipertensi pada masyarakat di wilayah kerja Puskesmas Aluh-Aluh. Rancangan penelitian menggunakan desain cross sectional berbasis data sekunder yang diambil dari data SIPTM (posbindu PTM periode Januari-April 2021) Dinas Kesehatan Kabupaten Banjar. Populasi dalam penelitian ini adalah seluruh masyarakat di wilayah kerja Puskesmas Aluh-Aluh sebanyak 815 orang. Sampel yang diambil sebanyak 725 orang sesuai dengan kriteria yang ditentukan menggunakan teknik purposive sampling. Analisis data menggunakan uji chi square. Hasil penelitian menunjukan ada hubungan perilaku merokok (p-value=0,026) dengan kejadian hipertensi. Sedangkan jenis kelamin (p-value=0,105), pendidikan terakhir (p-value=0,084), pekerjaan (p-value=0,426), status pernikahan (p-value=0,575), konsumsi buah dan sayur (p-value=0,072) menunjukan tidak ada hubungan dengan kejadian hipertensi. Kesimpulan penelitian ini adalah bahwa perilaku merokok secara bermakna beresiko tinggi menyebabkan kejadian hipertensi.

Background: Particularly developed ingredients that are easily manufactured and utilized for additional exploitation are used in organic synthetic chemistry. Thionyl chloride serves as a significant illustration of such an ingredient. The usefulness of which has been discussed in a huge number of peer-reviewed papers. Aim: The literature that has been released since the previous assessment in 1980, which mainly focused on the responses of active methylene compounds, is where this review places its focus. In the present overview, we also discuss O- and N-nucleophiles. For the most part, patents have been disregarded in this analysis in order to keep it feasible. Conclusion: The authors concluded that SOCl2 has a variety of behaviors, including the ability to function as an initiator or a reactant, which makes it essential for the synthesis of many chemically reactive intermediates and final products. Additionally, SOCl2 can speed up and reduce the duration of traditionally long reactions, thereby raising its importance.

Introduction: Understanding the concept of well-being from the perspective of the elderly and identifying its important factors can play a significant role in increasing the quality and satisfaction of the elderly. The purpose of the current research was "to design and validate a model for promoting the well-being of the elderly based on lived experiences and to examine its effectiveness on the psychological well-being of the elderly". Method: In this study, the descriptive phenomenology method was used to collect data and the Claysey method was used to analyze the data in the qualitative part. The number of participants was based on theoretical saturation of twenty elderly men and women living in Tehran province. Data were collected through semi-structured in-depth interviews. The obtained data were analyzed to explain the well-being factors in old age. The program obtained from the qualitative phase to improve the well-being of the elderly was taught to six elderly volunteers based on the AB single-case plan, and the results were evaluated through the RIF well-being questionnaire. Quantitative data analysis was done during the methods of stable change index, visual analysis and clinical significance using the recovery percentage formula and non-overlapping methods to determine the effectiveness of the program.Results: Five themes were extracted from the findings in the qualitative section, which include vitality, health and dynamism, Personal growth and enrichment, interpersonal relationships, and strength. Data analysis showed that the welfare program obtained for four volunteers of this program is effective. It should be noted that in single-subject designs, when the researcher can talk about the possibility of a functional relationship between the dependent variable and the intervention, this relationship is repeated for at least three participants.Discussion and conclusion: The results of this research can be used by many psychologists, counselors and experts in the field of geriatrics in the field of how to advise and educate the elderly in order to increase the well-being of the elderly. In addition, the officials and trustees of the elderly can expand the welfare in the elderly society by implementing the elderly welfare program, which will reduce the adverse effects of aging among them and make them more cheerful and energetic.