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112. DNA force-extension curve under uniaxial stretching

Author

Dalir, Hamid, unknown, unknown, Nisisako, Takasi, YANAGIDA, Yasuko, and HATSUZAWA, TAKESHI

Subjects
Imagination, Chemistry, Base pair, Hydrogen bond, Tension (physics), General Chemical Engineering, media_common.quotation_subject, General Chemistry, Mechanics, Bending, Condensed Matter Physics, chemistry.chemical_compound, Crystallography, Modeling and Simulation, General Materials Science, Point (geometry), Deformation (engineering), DNA, Information Systems, media_common
Abstract

Single-molecule experiments indicate that a double-stranded DNA (ds‐DNA) increases in length if put under tension greater than 10 pN; beyond this point, its conformation can no longer be described using an inextensible worm-like chain model. For this purpose, a general sequence-dependent elastic model for tensions greater than 10 pN and for both single-stranded (ss) and ds‐DNA is proposed, and the effective elastic bending and torsional rigidities are determined from experiments to characterise their deformation. The key to this progress is that the bending and torsional deformations of the DNA backbones, the base-stacking interactions and the hydrogen bond force between the complementary base pairs are quantitatively considered in this model. Moreover, this simple elastic model can be used to globally fit to the abrupt B–S experimental transition data over a wide range of DNA molecule extensions. Based on this robust model, further study may be warranted on the mechanical response of ss- and ds‐DNA molec...

Published
2009

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