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103. Heart Failure With Preserved Ejection Fraction in the Young

Author

Tromp, Jasper, MacDonald, Michael R., Tay, Wan Ting, Teng, Tiew-Hwa K., Hung, Chung-Lieh, Narasimhan, Calambur, Shimizu, Wataru, Ling, Lieng Hsi, Ng, Tze Pin, Yap, Jonathan, McMurray, John J.V., Zile, Michael R., Richards, A. Mark, Anand, Inder S., and Lam, Carolyn S.P.

Published
2018
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107. Body composition reference values in Singaporean adults using dual-energy X-ray absorptiometry—The Yishun study

Author

Soh, BaoLin Pauline, primary, Lee, Shuen Yee, additional, Wong, Wai Yin, additional, Pang, Benedict Wei Jun, additional, Lau, Lay Khoon, additional, Jabbar, Khalid Abdul, additional, Seah, Wei Ting, additional, Chen, Kexun Kenneth, additional, Srinivasan, Sivasubramanian, additional, Ng, Tze Pin, additional, and Wee, Shiou-Liang, additional

Published
2022
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110. Functional mobility decline and incident mild cognitive impairment and early dementia in community-dwelling older adults: the Singapore Longitudinal Ageing Study

Author

Ng, Tze Pin, primary, Lee, Tih Shih, additional, Lim, Wee Shiong, additional, Chong, Mei Sian, additional, Yap, Philip, additional, Cheong, Chin Yee, additional, Rawtaer, Iris, additional, Liew, Tau Ming, additional, Gwee, Xinyi, additional, Gao, Qi, additional, and Yap, Keng Bee, additional

Published
2022
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111. One-Carbon Metabolism Biomarkers and Risks of Incident Neurocognitive Disorder among Cognitively Normal Older Adults

Author

Przybycien-Gaweda, Paulina Maria, primary, Lee, Tih Shih, additional, Lim, Wee Shiong, additional, Chong, Mei Sian, additional, Yap, Philip, additional, Cheong, Chin Yee, additional, Rawtaer, Iris, additional, Liew, Tau Ming, additional, Gwee, Xinyi, additional, Gao, Qi, additional, Yap, Keng Bee, additional, and Ng, Tze Pin, additional

Published
2022
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112. Adequacy of Psychiatric Training: A Singaporean Perspective

Author

Tor, Phern-Chern, Ng, Tze-Pin, and Kua, Ee-Heok

Abstract

Objective: The specialty training program for psychiatry in Singapore is transitioning to a seamless 5-year training program. It is timely to assess the perceived adequacy of current psychiatric specialty training. Methods: An anonymous survey was sent to all psychiatry trainees and psychiatrists in the public sector to assess the current adequacy and perceived importance of 11 aspects of psychiatric specialist training. Results: Forty-nine percent of those surveyed (54 of 110) replied. The current adequacy of training was rated lower than the perceived importance of training for all 11 aspects of training. Those aspects of training rated most important were disorder and diagnosis, pharmacological treatment, clinical interview, and treatment skills. Psychiatrists rated most aspects of training as being more important than did trainees except for cultural aspects, research, and basic neuroscience. Psychiatrists rated adequacy of training better than did trainees, except in the aspect of research. The difference between psychiatrists' and trainees' ratings for adequacy of psychotherapy treatment knowledge was significant (p less than 0.05). Conclusion: There were perceived deficiencies in all 11 aspects of training. Psychiatrists and trainees have different perceptions of adequacy and importance of training.

Published
2010
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120. Association Between Use of Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitors and Cognitive Function in a Longitudinal Study of Patients with Type 2 Diabetes

Author

Low, Serena, primary, Goh, Kiat Sern, additional, Ng, Tze Pin, additional, Moh, Angela, additional, Ang, Su Fen, additional, Wang, Jiexun, additional, Ang, Keven, additional, Tang, Wern Ee, additional, Lim, Ziliang, additional, Subramaniam, Tavintharan, additional, Sum, Chee Fang, additional, and Lim, Su Chi, additional

Published
2022
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121. Higher ratio of extracellular water to total body water was associated with reduced cognitive function in type 2 diabetes

Author

NG Tze Pin, Su Chi Lim, Tavintharan Subramaniam, Chin Leong Lim, Angela Moh, Keven Ang, Serena Low, Chin Yee Cheong, Jiexun Wang, Kiat Sern Goh, Ziliang Lim, Wern Ee Tang, Chee Fang Sum, Philip Yap, and Su Fen Ang

Subjects
Male, Repeatable Battery for the Assessment of Neuropsychological Status, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Body water, Blood Pressure, 030209 endocrinology & metabolism, Type 2 diabetes, Neuropsychological Tests, 030204 cardiovascular system & hematology, 03 medical and health sciences, Cognition, 0302 clinical medicine, Body Water, Internal medicine, Diabetes mellitus, Edema, medicine, Humans, Aged, Glycated Hemoglobin, business.industry, Water, Middle Aged, medicine.disease, Confidence interval, Pulse pressure, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Linear Models, Cardiology, Female, medicine.symptom, Extracellular Space, business, Bioelectrical impedance analysis
Abstract

Fluid imbalance is associated with various clinical conditions, but the association between elevated extracellular-water to total-body-water (ECW/TBW) ratio, an indicator of fluid balance, and cognitive impairment is unknown. We aimed to investigate relationship between ECW/TBW ratio and cognitive function in type 2 diabetes mellitus.This study was a cross-sectional design, comparing 1233 patients aged 61.4 ± 8.0 years from the Singapore Study of Macro-angiopathy and Micro-vascular Reactivity in Type 2 Diabetes (SMART2D) cohort. ECW/TBW was measured using bioelectrical impedance method. Cognitive function was assessed with Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Multiple linear regression was used to examine association between ECW/TBW and RBANS scores, adjusting for demographics, education, clinical covariates, and apolipoprotein E allele.In unadjusted analyses, there was an inverse dose-dependent association between ECW/TBW and RBANS total score. The associations persisted in fully adjusted model with β = -1.18 (95% confidence interval [CI] -2.19 to -0.17; P = 0.022) for slight edema and -2.33 (-3.99 to -0.67; P = 0.006) for edema. Slight edema and edema were significantly associated with reduced cognitive function in delayed memory and attention. There was significant association between edema but not slight edema, with reduced cognitive function in language. Pulse pressure accounted for 16.8% of association between ECW/TBW and RBANS total score.Our novel finding of an independent association between higher ECW/TBW and poorer cognitive function highlights the potential importance of maintaining body fluid balance in the management of cognitive impairment.背景: 体液失衡与多种临床症状有关, 但作为体液平衡指标的细胞外液/全身水比值(ECW/TBW)升高与认知功能损害之间的关系尚不清楚。本研究旨在探讨2型糖尿病患者ECW/TBW比值与认知功能的关系。 方法: 本研究采用横断面设计, 比较了新加坡2型糖尿病大血管病变和微血管反应性研究(SMART2D)队列的1233例患者, 年龄在61.4±8.0岁。采用生物电阻抗法测量ECW/TBW。认知功能采用可重复使用的神经心理状态评定量表(RBANS)进行评定。在校正了人口统计学、教育程度、临床协变量和载脂蛋白E等位基因后, 采用多元线性回归来检验ECW/TBW和RBANS评分之间的相关性。 结果: 在非校正分析中, ECW/TBW与RBANS总分呈剂量负相关。这种关联持续存在于完全校正轻度水肿β=− 1.18(95% 置信区间 [CI] −2.19 to −0.17; P = 0.022)和水肿β= −2.33 (−3.99 to −0.67; P = 0.006) 的模型中。轻度水肿和水肿与延迟记忆和注意力的认知功能降低显著相关。语言认知功能下降与水肿之间有显著的相关性。脉搏压可解释ECW/TBW与RBANS总分相关性的16.8%。 结论: 我们首次发现较高的ECW/TBW和较差的认知功能之间存在独立的关联, 这突出了在认知障碍的管理中保持体液平衡的潜在重要性。.

Published
2020
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128. Educational Gradients in Disability among Asia’s Future Elderly: Projections for the Republic of Korea and Singapore

Author

CHEN, CYNTHIA, primary, LIM, JUE TAO, additional, CHIA, NGEE CHOON, additional, KIM, DAEJUNG, additional, PARK, HAEMI, additional, WANG, LIJIA, additional, TYSINGER, BRYAN, additional, ZHAO, MICHELLE, additional, COOK, ALEX R., additional, CHONG, MING ZHE, additional, YUAN, JIAN-MIN, additional, MA, STEFAN, additional, TAN, KELVIN BRYAN, additional, NG, TZE PIN, additional, KOH, WOON-PUAY, additional, YOONG, JOANNE, additional, BHATTACHARYA, JAY, additional, and EGGLESTON, KAREN, additional

Published
2022
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130. Additional file 1 of Associations of low handgrip strength and hand laterality with cognitive function and functional mobility – the Yishun Study

Author

Chen, Kexun Kenneth, Lee, Shuen Yee, Pang, Benedict Wei Jun, Lau, Lay Khoon, Jabbar, Khalid Abdul, Seah, Wei Ting, Tou, Nien Xiang, Yap, Philip Lin Kiat, Ng, Tze Pin, and Wee, Shiou-Liang

Abstract

Additional file 1: e-Table 1. Associations between handgrip strength groups and specific RBANS subtests in older adults.

Published
2022
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133. Physiological and Cognitive Determinants of Gait Variability of Asian Population: The Yishun Study.

Author

Lau, Lay Khoon, Abdul Jabbar, Khalid Bin, Pang, Wei Jun Benedict, Chen, Kexun Kenneth, Seah, Wei Ting, Ullal Mallya, Jagadish, Yap, Philip Lin Kiat, Ng, Tze-Pin, and Wee, Shiou Liang

Subjects
ASIANS, CONTRAST sensitivity (Vision), GAIT in humans, MIDDLE-aged persons, RESISTANCE training, WALKING speed, MUSCLE strength, COGNITION
Abstract

Introduction: Gait variability is associated with frailty, dementia, and falls. Studies on the association of physiological and cognitive factors with gait variability have seldom included middle-aged adults, even though these adults already experienced loss of muscular strength and postural stability. This study aimed a) to examine and compare the trend of gait variability in men and women, across the adult age spectrum, and b) to identify and compare the contributions of physiological and cognitive factors to gait variability. Methods: This was a population-based cross-sectional study at a single center. A random sample of 507 community-dwelling, well-functioning adults aged 21–90 years were studied. Cognition was measured using the Repeatable Battery for the Assessment of Neuropsychological Status. Physiological factors examined included visual contrast sensitivity (VCS), postural sway, hand reaction time, handgrip strength (HGS), knee extensor strength, and gait variability (coefficient of variation [CoV]). Multivariable regression models were used to examine the association between physiological and cognitive performance with gait CoV. Results: Women walked with greater stride width CoV (p < 0.01) and double support time (DST) CoV (p < 0.01) than men. The stride width (p = 0.01) and DST variability (p = 0.03) were significantly higher in older men as compared to men in younger age-groups. Gait speed accounted for most of the gait CoV variances and attenuated the effects of physiological performance and/or attention cognition on most gait variability, except for CoV of DST and stride width. Adults with better VCS (β = −0.19), faster hand reaction (β = 0.12), and greater HGS (β = −0.15) had lower variability in step length. Conclusion: The trends of stride width CoV and DST CoV across adult age spectrum were different between men and women. Greater stride width variability was partly attributed to greater HGS, possibly to better control lateral stability during walking. Physiological factors outweigh cognition in regulating most of the gait CoV in this study. They are modifiable and potential targets for healthy aging program. [ABSTRACT FROM AUTHOR]

Published
2023
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145. List of Contributors

Author

Abbatecola, Angela Marie, primary, Abe, Koji, additional, Abisambra, Jose F., additional, Ahmad, Aliya, additional, Alaei, Hojjatollah, additional, Alagiakrishnan, Kannayiram, additional, Aliev, Gjumrakch, additional, Allegri, Ricardo Francisco, additional, Almeida, Osvaldo P., additional, Álvarez-Cervera, Fernando J., additional, Alwi, Nor Amalina Ahmad, additional, Ames, David, additional, Anderson-Mooney, Amelia Jane, additional, Andrade, José Paulo, additional, Anglés, Neus, additional, Armstrong, R.A., additional, Assunção, Marco, additional, Atteia, Hebatallah Husseini, additional, Avila, Marco Fidel, additional, Bair, Ming-Jong, additional, Barbagallo, Mario, additional, Barberger-Gateau, Pascale, additional, Barbieri, Michelangela, additional, Barreto, George E., additional, Bata-García, José L., additional, Begum, Monirun, additional, Bellia, Francesco, additional, Belvedere, Mario, additional, Bennett, Louise E., additional, Białecka, Monika, additional, Bird, Michael, additional, Blundo, Carlo, additional, Boccardi, Virginia, additional, Bolea, Irene, additional, Bosco, Domenico, additional, Brouwer-Brolsma, Elske M., additional, Brust, John C.M., additional, Buffa, Roberto, additional, Bunner, Kendra D., additional, Burri, Lena, additional, Cabezas, Ricardo, additional, Camina, María Alicia, additional, Campbell, Tessa N., additional, Cano, Lourdes Rexach, additional, Chen, Huan-Lin, additional, Chen, Jianmin, additional, Cheung, David Wing-Shing, additional, Choy, Francis Y.M., additional, Chua, J., additional, Colica, Carmen, additional, Corcia, Philippe, additional, Craft, Suzanne, additional, Cristiano, Dario, additional, Cusimano, Michael D., additional, Dalton, Kate, additional, Davidson, Terry L., additional, De Bartolo, Matteo, additional, de Bem, Andreza Fabro, additional, de Castro, Isac, additional, de Groot, Lisette C.P.G.M., additional, de la Cruz Marcos, Sandra, additional, de Oliveira, Jade, additional, del Balzo, Valeria, additional, Deguchi, Kentaro, additional, Deguchi, Shoko, additional, Deth, Richard, additional, Dominguez, Ligia J., additional, Donini, Lorenzo M., additional, Doruk, Huseyin, additional, Dziewas, Rainer, additional, Díes, Rafael Carles, additional, El-Bachá, Ramon Santos, additional, El-Swefy, Sahar Elsayed, additional, Enciso, Laura Carreño, additional, Ermio, Caterina, additional, Escribano, Begoña M., additional, Estrada-Sánchez, Ana María, additional, Etgen, Thorleif, additional, Farina, Marcelo, additional, Fava, Antonietta, additional, Feart, Catherine, additional, Feng, Lei, additional, Fernández-Fernández, Laura, additional, Ferreira, Danilio Alvear Sampaio, additional, Fiala, Milan, additional, Fialdini, Renata Caruso, additional, Fisher, Cheryl, additional, Galimberti, Daniela, additional, Galvin, James E., additional, Gelber, Rebecca P., additional, Gerace, Carmela, additional, Giannakopoulos, Panteleimon, additional, Giannopoulos, Phillip F., additional, Giridharan, Vijayasree V., additional, Giusti, Anna Maria, additional, Gonzalez, Janneth, additional, Góngora-Alfaro, José L., additional, Gordon, Paul H., additional, Greiwe, Jeffrey S., additional, Grima, Natalie A., additional, Guedes, Rubem, additional, Gupta, Susham, additional, Gyengesi, Erika, additional, Haller, Sven, additional, Hanson, Angela J., additional, Harvey, Jenni, additional, Hassan, Ossama Morsi, additional, Henderson, Samuel T., additional, Herrup, Karl, additional, Hickey, M.A., additional, Hoerr, Robert, additional, Hou, Xiaoli, additional, Huang, Chengyu, additional, Hügel, Helmut M., additional, Hwang, Sam-Long, additional, Ikeda, Yoshio, additional, Irie, Kazuhiro, additional, Jack, Alexandria, additional, Jackson, Neale, additional, Jackson, Richard L., additional, Jannise, Brittany, additional, Jiang, Yugang, additional, Johnson, C.Shanthi, additional, Jolliff, James S., additional, Jové, Mariona, additional, Kam, Jonathan S., additional, Kanoski, Scott E., additional, Khan, Khurshid, additional, Kimura, Takemi, additional, Kitagishi, Yasuko, additional, Konishi, Tetsuya, additional, Kovacs, Gabor G., additional, Krause, Debra, additional, Kua, Ee-Heok, additional, Kurata, Tomoko, additional, Kurian, Mini, additional, Kwok, Timothy, additional, Lam, Wai Ping, additional, Lattanzio, Fabrizia, additional, Lawrence, Catherine B., additional, Lee, Tih-Shih, additional, Lee, Yuan-Kai, additional, Leslie, Paula, additional, Leung, Ping Chung, additional, Li, Runping, additional, Liang, Willmann, additional, Lim, Siong-Meng, additional, Lin, Fengwu, additional, Lin, I-Tsung, additional, Loef, Martin, additional, Lovblad, Karl-Olof, additional, Luque, Evelio, additional, Luz, Protásio Lemos da, additional, Macaulay, S.Lance, additional, Madan, Swati, additional, Maetzler, Walter, additional, Mahendran, R., additional, Majeed, Abu Bakar Abdul, additional, Mander, Alastair G., additional, Mani, Vasudevan, additional, Manley, Graham, additional, Manor, Danny, additional, Margetts, Christine, additional, Marini, Elisabetta, additional, Martin-Fernandez, J.Javier, additional, Martínez-Martos, José Manuel, additional, Martínez, Irene Villegas, additional, de Mateo Silleras, Beatriz, additional, Matsuda, Satoru, additional, May, Brian H., additional, McGirr, Alexander, additional, McCormick, Laurie M., additional, Mehta, Jatin, additional, Mereu, Elena, additional, Messina, Antonino, additional, Minami, Akari, additional, Mirowsky, John, additional, Moore, Eileen M., additional, Moreira, Eduardo Luiz Gasnhar, additional, Morelló, José Ramón, additional, Mori, Takashi, additional, Münch, Gerald, additional, Murakami, Kazuma, additional, Mutter, Joachim, additional, Naharci, Mehmet Ilkin, additional, Nakao, Frank Shigeo, additional, Ng, Tze-Pin, additional, Nigro, Julie, additional, Ninomiya, Toshiharu, additional, Nishiyama, Marcelo, additional, Nomani, Erum, additional, Nooyens, Astrid C.J., additional, Oda, Adriana Leico, additional, Okamura, Hitoshi, additional, Oliveira, Acary Souza Bulle, additional, Ono, Yuna, additional, Orsitto, Giuseppe, additional, Ozawa, Mio, additional, Pallet, Véronique, additional, Pamplona, Reinald, additional, Paolisso, Giuseppe, additional, Paradiso, Sergio, additional, Pase, Matthew P., additional, Patki, Gaurav, additional, Piguet, Olivier, additional, Pinto, Alessandro, additional, Pirritano, Domenico, additional, Plastino, Massimiliano, additional, Poggiogalle, Eleonora, additional, Polidori, M.Cristina, additional, Polimanti, Renato, additional, Portero-Otin, Manuel, additional, Power, Brian D., additional, Praticò, Domenico, additional, Prediger, Rui Daniel S., additional, Preedy, Victor R., additional, Prendergast, Mark A., additional, Rae, Daniela, additional, Ramasamy, Kalavathy, additional, Ramli, Muhammad Zaki, additional, Ramirez, Bartolomé, additional, Ramírez-Expósito, María Jesús, additional, Rebec, George V., additional, Reddy, V.Prakash, additional, Redondo del Río, María Paz, additional, Reguant, Jordi, additional, Reisi, Parham, additional, Remington, Ruth, additional, Ricci, Monica, additional, Rizzarelli, Enrico, additional, Robinson, Stephen R., additional, Rogers, Eugene, additional, Rosini, Francesca, additional, Roupas, Peter, additional, Rufa, Alessandra, additional, Russo, María Julieta, additional, Sahathevan, Ramesh, additional, Salim, Samina, additional, Salvioni, Cristina Cleide dos Santos, additional, Sample, Camille H., additional, Santamaría, Abel, additional, Saqqur, Maher, additional, Saragat, Bruno, additional, Sauvant, Julie, additional, Sauvant, Patrick, additional, Scarpini, Elio, additional, Scelza, M.F.Z., additional, Schwen, Richard J., additional, Self, Rachel L., additional, Serrano, José C.E., additional, Shea, Thomas B., additional, Shih, Ping-Hsiao, additional, Shimizu, Takahiko, additional, Shunichiro, Shinagawa, additional, Siahmard, Zahra, additional, Sławek, Jarosław, additional, Smoliner, Christine, additional, Solé, Montse, additional, Sprini, Delia, additional, Squitti, Rosanna, additional, Srulijes, Karin, additional, Stahl, Wilhelm, additional, Stanich, Patricia, additional, Stephens, Brian R., additional, Sun, Mingxue, additional, Takamatsu, Junichi, additional, Tang, Hong Chai, additional, Thandavarayan, Rajarajan A., additional, Torrente, Daniel, additional, Town, Terrence, additional, Túnez, Isaac, additional, Ulatowski, Lynn, additional, Unzeta, Mercedes, additional, Valente, Tony, additional, van Keizerswaard, Jolanda, additional, van de Rest, Ondine, additional, van der Zwaluw, Nikita L., additional, Vecchio, Graziella, additional, Veiga, Judith Jimenez, additional, Vila-Rodriguez, Fidel, additional, Walach, Harald, additional, Warnecke, Tobias, additional, Watters, David A.K., additional, Weber, Wolfgang, additional, Weitzman, Rachel, additional, White, Lon R., additional, Wirth, Rainer, additional, Wu, Chia-Hsien, additional, Xiao, Kai, additional, Xue, Charlie C.L., additional, Yen, Gow-Chin, additional, Yew, David Tai-Wai, additional, Yokoi, Teruo, additional, Zhang, Anthony L., additional, Zhang, Lihong, additional, and Zito, Giancarlo, additional

Published
2015
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146. Tea and Cognitive Health

Author

Feng, Lei, primary, Ng, Tze-Pin, additional, Kua, Ee-Heok, additional, Lee, Tih-Shih, additional, and Preedy, Victor R., additional

Published
2015
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