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16,367 results on '"Nawrocki A"'

102. Challenges Related to the Implementation of an EMS-Administered, Large Vessel Occlusion Stroke Score

Author

Lawner, Benjamin J., Szabo, Kelly, Daly, Jonathan, Foster, Krista M., McCoy, Philip, Poliner, David, Poremba, Matthew, Nawrocki, Philip S., and Rahangdale, Rahul

Abstract

Introduction: There is considerable interest in triaging victims of large vessel occlusion (LVO) strokes to comprehensive stroke centers. Timely access to interventional therapy has been linked to improved stroke outcomes. Accurate triage depends upon the use of a validated screening tool in addition to several emergency medical system (EMS)-specific factors. This study examines the integration of a modified Rapid Arterial oCcclusion Evaluation (mRACE) score into an existing stroke treatment protocol.Methods: We performed a retrospective review of EMS and hospital charts of patients transported to a single comprehensive stroke center. Adult patients with an EMS provider impression of “stroke/TIA,” “CVA,” or “neurological problem” were included for analysis. EMS protocols mandated the use of the Cincinnati Prehospital Stroke Score (CPSS). The novel protocol authorized the use of the mRACE score to identify candidates for triage directly to the comprehensive stroke center. We calculated specificity and sensitivity for various stroke screens (CPSS and a mRACE exam) for the detection of LVO stroke. The score’s metrics were evaluated as a surrogate marker for a successful EMS triage protocol.Results: We included 312 prehospital charts in the final analysis. The CPSS score exhibited reliable sensitivity at 85%. Specificity of CPSS for an LVO was calculated at 73%. For an mRACE score of five or greater, the sensitivity was 25%. Specificity for mRACE was calculated at 75%. The positive predictive value of the mRACE score for an LVO was estimated at 12.50%.Conclusion: In this retrospective study of patients triaged to a single comprehensive stroke center, the addition of an LVO-specific screening tool failed to improve accuracy. Reliable triage of LVO strokes in the prehospital setting is a challenging task. In addition to statistical performance of a particular stroke score, a successful EMS protocol should consider system-based factors such as provider education and training. Study limitations can inform future iterations of LVO triage protocols.

Published
2020

108. An Approach to Modeling a Real-Time Updated Environment Based on Messages from Agents

Author

Krótkiewicz, Marek, Wojtkiewicz, Krystian, Jodłowiec, Marcin, Palak, Rafał, Szczerbicki, Mikołaj, Nawrocki, Piotr, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Nguyen, Ngoc Thanh, editor, Manolopoulos, Yannis, editor, Chbeir, Richard, editor, Kozierkiewicz, Adrianna, editor, and Trawiński, Bogdan, editor

Published
2022
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109. Erratum to: Searches for long-lived charged particles in pp collisions at s $$ \sqrt{\textrm{s}} $$ = 7 and 8 TeV

Author

The CMS collaboration, S. Chatrchyan, V. Khachatryan, A. M. Sirunyan, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, C. Fabjan, M. Friedl, R. Frühwirth, V. M. Ghete, N. Hörmann, J. Hrubec, M. Jeitler, W. Kiesenhofer, V. Knünz, M. Krammer, I. Krätschmer, D. Liko, I. Mikulec, D. Rabady, B. Rahbaran, C. Rohringer, H. Rohringer, R. Schöfbeck, J. Strauss, A. Taurok, W. Treberer-Treberspurg, W. Waltenberger, C.-E. Wulz, V. Mossolov, N. Shumeiko, J. Suarez Gonzalez, S. Alderweireldt, M. Bansal, S. Bansal, T. Cornelis, E. A. De Wolf, X. Janssen, A. Knutsson, S. Luyckx, L. Mucibello, S. Ochesanu, B. Roland, R. Rougny, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, A. Van Spilbeeck, F. Blekman, S. Blyweert, J. D’Hondt, A. Kalogeropoulos, J. Keaveney, M. Maes, A. Olbrechts, S. Tavernier, W. Van Doninck, P. Van Mulders, G. P. Van Onsem, I. Villella, B. Clerbaux, G. De Lentdecker, L. Favart, A. P. R. Gay, T. Hreus, A. Léonard, P. E. Marage, A. Mohammadi, L. Perniè, T. Reis, T. Seva, L. Thomas, C. Vander Velde, P. Vanlaer, J. Wang, V. Adler, K. Beernaert, L. Benucci, A. Cimmino, S. Costantini, S. Dildick, G. Garcia, B. Klein, J. Lellouch, A. Marinov, J. Mccartin, A. A. Ocampo Rios, D. Ryckbosch, M. Sigamani, N. Strobbe, F. Thyssen, M. Tytgat, S. Walsh, E. Yazgan, N. Zaganidis, S. Basegmez, C. Beluffi, G. Bruno, R. Castello, A. Caudron, L. Ceard, C. Delaere, T. du Pree, D. Favart, L. Forthomme, A. Giammanco, J. Hollar, P. Jez, V. Lemaitre, J. Liao, O. Militaru, C. Nuttens, D. Pagano, A. Pin, K. Piotrzkowski, A. Popov, M. Selvaggi, J. M. Vizan Garcia, N. Beliy, T. Caebergs, E. Daubie, G. H. Hammad, G. A. Alves, M. Correa Martins Junior, T. Martins, M. E. Pol, M. H. G. Souza, W. L. Aldá Júnior, W. Carvalho, J. Chinellato, A. Custódio, E. M. Da Costa, D. De Jesus Damiao, C. De Oliveira Martins, S. Fonseca De Souza, H. Malbouisson, M. Malek, D. Matos Figueiredo, L. Mundim, H. Nogima, W. L. Prado Da Silva, A. Santoro, A. Sznajder, E. J. Tonelli Manganote, A. Vilela Pereira, C. A. Bernardes, F. A. Dias, T. R. Fernandez Perez Tomei, E. M. Gregores, C. Lagana, F. Marinho, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, V. Genchev, P. Iaydjiev, S. Piperov, M. Rodozov, G. Sultanov, M. Vutova, A. Dimitrov, R. Hadjiiska, V. Kozhuharov, L. Litov, B. Pavlov, P. Petkov, J. G. Bian, G. M. Chen, H. S. Chen, C. H. Jiang, D. Liang, S. Liang, X. Meng, J. Tao, X. Wang, Z. Wang, H. Xiao, M. Xu, C. Asawatangtrakuldee, Y. Ban, Y. Guo, W. Li, S. Liu, Y. Mao, S. J. Qian, H. Teng, D. Wang, L. Zhang, W. Zou, C. Avila, C. A. Carrillo Montoya, J. P. Gomez, B. Gomez Moreno, J. C. Sanabria, N. Godinovic, D. Lelas, R. Plestina, D. Polic, I. Puljak, Z. Antunovic, M. Kovac, V. Brigljevic, S. Duric, K. Kadija, J. Luetic, D. Mekterovic, S. Morovic, L. Tikvica, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, M. Finger, Y. Assran, A. Ellithi Kamel, M. A. Mahmoud, A. Mahrous, A. Radi, M. Kadastik, M. Müntel, M. Murumaa, M. Raidal, L. Rebane, A. Tiko, P. Eerola, G. Fedi, M. Voutilainen, J. Härkönen, V. Karimäki, R. Kinnunen, M. J. Kortelainen, T. Lampén, K. Lassila-Perini, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, T. Peltola, E. Tuominen, J. Tuominiemi, E. Tuovinen, L. Wendland, A. Korpela, T. Tuuva, M. Besancon, S. Choudhury, F. Couderc, M. Dejardin, D. Denegri, B. Fabbro, J. L. Faure, F. Ferri, S. Ganjour, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, E. Locci, J. Malcles, L. Millischer, A. Nayak, J. Rander, A. Rosowsky, M. Titov, S. Baffioni, F. Beaudette, L. Benhabib, L. Bianchini, M. Bluj, P. Busson, C. Charlot, N. Daci, T. Dahms, M. Dalchenko, L. Dobrzynski, A. Florent, R. Granier de Cassagnac, M. Haguenauer, P. Miné, C. Mironov, I. N. Naranjo, M. Nguyen, C. Ochando, P. Paganini, D. Sabes, R. Salerno, Y. Sirois, C. Veelken, A. Zabi, J.-L. Agram, J. Andrea, D. Bloch, D. Bodin, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, C. Goetzmann, P. Juillot, A.-C. Le Bihan, P. Van Hove, S. Gadrat, S. Beauceron, N. Beaupere, G. Boudoul, S. Brochet, J. Chasserat, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, S. Gascon, M. Gouzevitch, B. Ille, T. Kurca, M. Lethuillier, L. Mirabito, S. Perries, L. Sgandurra, V. Sordini, Y. Tschudi, M. Vander Donckt, P. Verdier, S. Viret, Z. Tsamalaidze, C. Autermann, S. Beranek, B. Calpas, M. Edelhoff, L. Feld, N. Heracleous, O. Hindrichs, K. Klein, A. Ostapchuk, A. Perieanu, F. Raupach, J. Sammet, S. Schael, D. Sprenger, H. Weber, B. Wittmer, V. Zhukov, M. Ata, J. Caudron, E. Dietz-Laursonn, D. Duchardt, M. Erdmann, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, D. Klingebiel, P. Kreuzer, M. Merschmeyer, A. Meyer, M. Olschewski, K. Padeken, P. Papacz, H. Pieta, H. Reithler, S. A. Schmitz, L. Sonnenschein, J. Steggemann, D. Teyssier, S. Thüer, M. Weber, V. Cherepanov, Y. Erdogan, G. Flügge, H. Geenen, M. Geisler, W. Haj Ahmad, F. Hoehle, B. Kargoll, T. Kress, Y. Kuessel, J. Lingemann, A. Nowack, I. M. Nugent, L. Perchalla, O. Pooth, A. Stahl, M. Aldaya Martin, I. Asin, N. Bartosik, J. Behr, W. Behrenhoff, U. Behrens, M. Bergholz, A. Bethani, K. Borras, A. Burgmeier, A. Cakir, L. Calligaris, A. Campbell, F. Costanza, C. Diez Pardos, S. Dooling, T. Dorland, G. Eckerlin, D. Eckstein, G. Flucke, A. Geiser, I. Glushkov, P. Gunnellini, S. Habib, J. Hauk, G. Hellwig, H. Jung, M. Kasemann, P. Katsas, C. Kleinwort, H. Kluge, M. Krämer, D. Krücker, E. Kuznetsova, W. Lange, J. Leonard, K. Lipka, W. Lohmann, B. Lutz, R. Mankel, I. Marfin, I.-A. Melzer-Pellmann, A. B. Meyer, J. Mnich, A. Mussgiller, S. Naumann-Emme, O. Novgorodova, F. Nowak, J. Olzem, H. Perrey, A. Petrukhin, D. Pitzl, R. Placakyte, A. Raspereza, P. M. Ribeiro Cipriano, C. Riedl, E. Ron, M. Ö. Sahin, J. Salfeld-Nebgen, R. Schmidt, T. Schoerner-Sadenius, N. Sen, M. Stein, R. Walsh, C. Wissing, V. Blobel, H. Enderle, J. Erfle, U. Gebbert, M. Görner, M. Gosselink, J. Haller, K. Heine, R. S. Höing, G. Kaussen, H. Kirschenmann, R. Klanner, R. Kogler, J. Lange, I. Marchesini, T. Peiffer, N. Pietsch, D. Rathjens, C. Sander, H. Schettler, P. Schleper, E. Schlieckau, A. Schmidt, M. Schröder, T. Schum, M. Seidel, J. Sibille, V. Sola, H. Stadie, G. Steinbrück, J. Thomsen, D. Troendle, L. Vanelderen, C. Barth, C. Baus, J. Berger, C. Böser, T. Chwalek, W. De Boer, A. Descroix, A. Dierlamm, M. Feindt, M. Guthoff, C. Hackstein, F. Hartmann, T. Hauth, M. Heinrich, H. Held, K. H. Hoffmann, U. Husemann, I. Katkov, J. R. Komaragiri, A. Kornmayer, P. Lobelle Pardo, D. Martschei, S. Mueller, Th. Müller, M. Niegel, A. Nürnberg, O. Oberst, J. Ott, G. Quast, K. Rabbertz, F. Ratnikov, S. Röcker, F.-P. Schilling, G. Schott, H. J. Simonis, F. M. Stober, R. Ulrich, J. Wagner-Kuhr, S. Wayand, T. Weiler, M. Zeise, G. Anagnostou, G. Daskalakis, T. Geralis, S. Kesisoglou, A. Kyriakis, D. Loukas, A. Markou, C. Markou, E. Ntomari, L. Gouskos, T. J. Mertzimekis, A. Panagiotou, N. Saoulidou, E. Stiliaris, X. Aslanoglou, I. Evangelou, G. Flouris, C. Foudas, P. Kokkas, N. Manthos, I. Papadopoulos, E. Paradas, G. Bencze, C. Hajdu, P. Hidas, D. Horvath, B. Radics, F. Sikler, V. Veszpremi, G. Vesztergombi, A. J. Zsigmond, N. Beni, S. Czellar, J. Molnar, J. Palinkas, Z. Szillasi, J. Karancsi, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. B. Beri, V. Bhatnagar, N. Dhingra, R. Gupta, M. Kaur, M. Z. Mehta, M. Mittal, N. Nishu, L. K. Saini, A. Sharma, J. B. Singh, Ashok Kumar, Arun Kumar, S. Ahuja, A. Bhardwaj, B. C. Choudhary, S. Malhotra, M. Naimuddin, K. Ranjan, P. Saxena, V. Sharma, R. K. Shivpuri, S. Banerjee, S. Bhattacharya, K. Chatterjee, S. Dutta, B. Gomber, Sa. Jain, Sh. Jain, R. Khurana, A. Modak, S. Mukherjee, D. Roy, S. Sarkar, M. Sharan, A. Abdulsalam, D. Dutta, S. Kailas, V. Kumar, A. K. Mohanty, L. M. Pant, P. Shukla, A. Topkar, T. Aziz, R. M. Chatterjee, S. Ganguly, S. Ghosh, M. Guchait, A. Gurtu, G. Kole, S. Kumar, M. Maity, G. Majumder, K. Mazumdar, G. B. Mohanty, B. Parida, K. Sudhakar, N. Wickramage, S. Dugad, H. Arfaei, H. Bakhshiansohi, S. M. Etesami, A. Fahim, H. Hesari, A. Jafari, M. Khakzad, M. Mohammadi Najafabadi, S. Paktinat Mehdiabadi, B. Safarzadeh, M. Zeinali, M. Grunewald, M. Abbrescia, L. Barbone, C. Calabria, S. S. Chhibra, A. Colaleo, D. Creanza, N. De Filippis, M. De Palma, L. Fiore, G. Iaselli, G. Maggi, M. Maggi, B. Marangelli, S. My, S. Nuzzo, N. Pacifico, A. Pompili, G. Pugliese, G. Selvaggi, L. Silvestris, G. Singh, R. Venditti, P. Verwilligen, G. Zito, G. Abbiendi, A. C. Benvenuti, D. Bonacorsi, S. Braibant-Giacomelli, L. Brigliadori, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, S. Marcellini, G. Masetti, M. Meneghelli, A. Montanari, F. L. Navarria, F. Odorici, A. Perrotta, F. Primavera, A. M. Rossi, T. Rovelli, G. P. Siroli, N. Tosi, R. Travaglini, S. Albergo, M. Chiorboli, S. Costa, F. Giordano, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, S. Frosali, E. Gallo, S. Gonzi, V. Gori, P. Lenzi, M. Meschini, S. Paoletti, G. Sguazzoni, A. Tropiano, L. Benussi, S. Bianco, D. Piccolo, P. Fabbricatore, R. Musenich, S. Tosi, A. Benaglia, F. De Guio, L. Di Matteo, S. Fiorendi, S. Gennai, A. Ghezzi, P. Govoni, M. T. Lucchini, S. Malvezzi, R. A. Manzoni, A. Martelli, D. Menasce, L. Moroni, M. Paganoni, D. Pedrini, S. Ragazzi, N. Redaelli, T. Tabarelli de Fatis, S. Buontempo, N. Cavallo, A. De Cosa, F. Fabozzi, A. O. M. Iorio, L. Lista, S. Meola, M. Merola, P. Paolucci, P. Azzi, N. Bacchetta, D. Bisello, A. Branca, R. Carlin, P. Checchia, T. Dorigo, U. Dosselli, M. Galanti, F. Gasparini, U. Gasparini, P. Giubilato, A. Gozzelino, M. Gulmini, K. Kanishchev, S. Lacaprara, I. Lazzizzera, M. Margoni, G. Maron, A. T. Meneguzzo, J. Pazzini, N. Pozzobon, P. Ronchese, F. Simonetto, E. Torassa, M. Tosi, S. Vanini, P. Zotto, A. Zucchetta, G. Zumerle, M. Gabusi, S. P. Ratti, C. Riccardi, P. Vitulo, M. Biasini, G. M. Bilei, L. Fanò, P. Lariccia, G. Mantovani, M. Menichelli, A. Nappi, F. Romeo, A. Saha, A. Santocchia, A. Spiezia, K. Androsov, P. Azzurri, G. Bagliesi, T. Boccali, G. Broccolo, R. Castaldi, R. T. D’Agnolo, R. Dell’Orso, F. Fiori, L. Foà, A. Giassi, A. Kraan, F. Ligabue, T. Lomtadze, L. Martini, A. Messineo, F. Palla, A. Rizzi, A. T. Serban, P. Spagnolo, P. Squillacioti, R. Tenchini, G. Tonelli, A. Venturi, P. G. Verdini, C. Vernieri, L. Barone, F. Cavallari, D. Del Re, M. Diemoz, M. Grassi, E. Longo, F. Margaroli, P. Meridiani, F. Micheli, S. Nourbakhsh, G. Organtini, R. Paramatti, S. Rahatlou, L. Soffi, N. Amapane, R. Arcidiacono, S. Argiro, M. Arneodo, C. Biino, N. Cartiglia, S. Casasso, M. Costa, N. Demaria, C. Mariotti, S. Maselli, E. Migliore, V. Monaco, M. Musich, M. M. Obertino, G. Ortona, N. Pastrone, M. Pelliccioni, A. Potenza, A. Romero, M. Ruspa, R. Sacchi, A. Solano, A. Staiano, U. Tamponi, S. Belforte, V. Candelise, M. Casarsa, F. Cossutti, G. Della Ricca, B. Gobbo, C. La Licata, M. Marone, D. Montanino, A. Penzo, A. Schizzi, A. Zanetti, T. Y. Kim, S. K. Nam, S. Chang, D. H. Kim, G. N. Kim, J. E. Kim, D. J. Kong, Y. D. Oh, H. Park, D. C. Son, J. Y. Kim, Zero J. Kim, S. Song, S. Choi, D. Gyun, B. Hong, M. Jo, H. Kim, T. J. Kim, K. S. Lee, S. K. Park, Y. Roh, M. Choi, J. H. Kim, C. Park, I. C. Park, S. Park, G. Ryu, Y. Choi, Y. K. Choi, J. Goh, M. S. Kim, E. Kwon, B. Lee, J. Lee, S. Lee, H. Seo, I. Yu, I. Grigelionis, A. Juodagalvis, H. Castilla-Valdez, E. De La Cruz-Burelo, I. Heredia-de La Cruz, R. Lopez-Fernandez, J. Martínez-Ortega, A. Sanchez-Hernandez, L. M. Villasenor-Cendejas, S. Carrillo Moreno, F. Vazquez Valencia, H. A. Salazar Ibarguen, E. Casimiro Linares, A. Morelos Pineda, M. A. Reyes-Santos, D. Krofcheck, A. J. Bell, P. H. Butler, R. Doesburg, S. Reucroft, H. Silverwood, M. Ahmad, M. I. Asghar, J. Butt, H. R. Hoorani, S. Khalid, W. A. Khan, T. Khurshid, S. Qazi, M. A. Shah, M. Shoaib, H. Bialkowska, B. Boimska, T. Frueboes, M. Górski, M. Kazana, K. Nawrocki, K. Romanowska-Rybinska, M. Szleper, G. Wrochna, P. Zalewski, G. Brona, K. Bunkowski, M. Cwiok, W. Dominik, K. Doroba, A. Kalinowski, M. Konecki, J. Krolikowski, M. Misiura, W. Wolszczak, N. Almeida, P. Bargassa, A. David, P. Faccioli, P. G. Ferreira Parracho, M. Gallinaro, J. Rodrigues Antunes, J. Seixas, J. Varela, P. Vischia, P. Bunin, M. Gavrilenko, I. Golutvin, I. Gorbunov, A. Kamenev, V. Karjavin, V. Konoplyanikov, G. Kozlov, A. Lanev, A. Malakhov, V. Matveev, P. Moisenz, V. Palichik, V. Perelygin, S. Shmatov, N. Skatchkov, V. Smirnov, A. Zarubin, S. Evstyukhin, V. Golovtsov, Y. Ivanov, V. Kim, P. Levchenko, V. Murzin, V. Oreshkin, I. Smirnov, V. Sulimov, L. Uvarov, S. Vavilov, A. Vorobyev, An. Vorobyev, Yu. Andreev, A. Dermenev, S. Gninenko, N. Golubev, M. Kirsanov, N. Krasnikov, A. Pashenkov, D. Tlisov, A. Toropin, V. Epshteyn, M. Erofeeva, V. Gavrilov, N. Lychkovskaya, V. Popov, G. Safronov, S. Semenov, A. Spiridonov, V. Stolin, E. Vlasov, A. Zhokin, V. Andreev, M. Azarkin, I. Dremin, M. Kirakosyan, A. Leonidov, G. Mesyats, S. V. Rusakov, A. Vinogradov, A. Belyaev, E. Boos, V. Bunichev, M. Dubinin, L. Dudko, A. Ershov, A. Gribushin, V. Klyukhin, O. Kodolova, I. Lokhtin, A. Markina, S. Obraztsov, V. Savrin, A. Snigirev, I. Azhgirey, I. Bayshev, S. Bitioukov, V. Kachanov, A. Kalinin, D. Konstantinov, V. Krychkine, V. Petrov, R. Ryutin, A. Sobol, L. Tourtchanovitch, S. Troshin, N. Tyurin, A. Uzunian, A. Volkov, P. Adzic, M. Ekmedzic, D. Krpic, J. Milosevic, M. Aguilar-Benitez, J. Alcaraz Maestre, C. Battilana, E. Calvo, M. Cerrada, M. Chamizo Llatas, N. Colino, B. De La Cruz, A. Delgado Peris, D. Domínguez Vázquez, C. Fernandez Bedoya, J. P. Fernández Ramos, A. Ferrando, J. Flix, M. C. Fouz, P. Garcia-Abia, O. Gonzalez Lopez, S. Goy Lopez, J. M. Hernandez, M. I. Josa, G. Merino, E. Navarro De Martino, J. Puerta Pelayo, A. Quintario Olmeda, I. Redondo, L. Romero, J. Santaolalla, M. S. Soares, C. Willmott, C. Albajar, J. F. de Trocóniz, H. Brun, J. Cuevas, J. Fernandez Menendez, S. Folgueras, I. Gonzalez Caballero, L. Lloret Iglesias, J. Piedra Gomez, J. A. Brochero Cifuentes, I. J. Cabrillo, A. Calderon, S. H. Chuang, J. Duarte Campderros, M. Fernandez, G. Gomez, J. Gonzalez Sanchez, A. Graziano, C. Jorda, A. Lopez Virto, J. Marco, R. Marco, C. Martinez Rivero, F. Matorras, F. J. Munoz Sanchez, T. Rodrigo, A. Y. Rodríguez-Marrero, A. Ruiz-Jimeno, L. Scodellaro, I. Vila, R. Vilar Cortabitarte, D. Abbaneo, E. Auffray, G. Auzinger, M. Bachtis, P. Baillon, A. H. Ball, D. Barney, J. Bendavid, J. F. Benitez, C. Bernet, G. Bianchi, P. Bloch, A. Bocci, A. Bonato, O. Bondu, C. Botta, H. Breuker, T. Camporesi, G. Cerminara, T. Christiansen, J. A. Coarasa Perez, S. Colafranceschi, D. d’Enterria, A. Dabrowski, A. De Roeck, S. De Visscher, S. Di Guida, M. Dobson, N. Dupont-Sagorin, A. Elliott-Peisert, J. Eugster, W. Funk, G. Georgiou, M. 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Petrucciani, M. Pieri, M. Sani, S. Simon, E. Sudano, M. Tadel, Y. Tu, A. Vartak, S. Wasserbaech, F. Würthwein, A. Yagil, J. Yoo, D. Barge, R. Bellan, C. Campagnari, M. D’Alfonso, T. Danielson, K. Flowers, P. Geffert, C. George, F. Golf, J. Incandela, C. Justus, P. Kalavase, D. Kovalskyi, V. Krutelyov, S. Lowette, R. Magaña Villalba, N. Mccoll, V. Pavlunin, J. Ribnik, J. Richman, R. Rossin, D. Stuart, W. To, C. West, A. Apresyan, A. Bornheim, J. Bunn, Y. Chen, E. Di Marco, J. Duarte, D. Kcira, Y. Ma, A. Mott, H. B. Newman, C. Rogan, M. Spiropulu, V. Timciuc, J. Veverka, R. Wilkinson, S. Xie, Y. Yang, R. Y. Zhu, V. Azzolini, A. Calamba, R. Carroll, T. Ferguson, Y. Iiyama, D. W. Jang, Y. F. Liu, M. Paulini, J. Russ, H. Vogel, I. Vorobiev, J. P. Cumalat, B. R. Drell, W. T. Ford, A. Gaz, E. Luiggi Lopez, U. Nauenberg, J. G. Smith, K. Stenson, K. A. Ulmer, S. R. Wagner, J. Alexander, A. Chatterjee, N. Eggert, L. K. Gibbons, W. Hopkins, A. Khukhunaishvili, B. Kreis, N. Mirman, G. Nicolas Kaufman, J. R. Patterson, A. Ryd, E. Salvati, W. Sun, W. D. Teo, J. Thom, J. Thompson, J. Tucker, Y. Weng, L. Winstrom, P. Wittich, D. Winn, S. Abdullin, M. Albrow, J. Anderson, G. Apollinari, L. A. T. Bauerdick, A. Beretvas, J. Berryhill, P. C. Bhat, K. Burkett, J. N. Butler, V. Chetluru, H. W. K. Cheung, F. Chlebana, S. Cihangir, V. D. Elvira, I. Fisk, J. Freeman, Y. Gao, E. Gottschalk, L. Gray, D. Green, O. Gutsche, D. Hare, R. M. Harris, J. Hirschauer, B. Hooberman, S. Jindariani, M. Johnson, U. Joshi, B. Klima, S. Kunori, S. Kwan, C. Leonidopoulos, J. Linacre, D. Lincoln, R. Lipton, J. Lykken, K. Maeshima, J. M. Marraffino, V. I. Martinez Outschoorn, S. Maruyama, D. Mason, P. McBride, K. Mishra, S. Mrenna, Y. Musienko, C. Newman-Holmes, V. O’Dell, O. Prokofyev, N. Ratnikova, E. Sexton-Kennedy, S. Sharma, W. J. Spalding, L. Spiegel, L. Taylor, S. Tkaczyk, N. V. Tran, L. Uplegger, E. W. Vaandering, R. Vidal, J. Whitmore, W. Wu, F. Yang, J. C. Yun, D. Acosta, P. Avery, D. Bourilkov, M. Chen, T. Cheng, S. Das, M. De Gruttola, G. P. Di Giovanni, D. Dobur, A. Drozdetskiy, R. D. Field, M. Fisher, Y. Fu, I. K. Furic, J. Hugon, B. Kim, J. Konigsberg, A. Korytov, A. Kropivnitskaya, T. Kypreos, J. F. Low, K. Matchev, P. Milenovic, G. Mitselmakher, L. Muniz, R. Remington, A. Rinkevicius, N. Skhirtladze, M. Snowball, J. Yelton, M. Zakaria, V. Gaultney, S. Hewamanage, L. M. Lebolo, S. Linn, P. Markowitz, G. Martinez, J. L. Rodriguez, T. Adams, A. Askew, J. Bochenek, J. Chen, B. Diamond, S. V. Gleyzer, J. Haas, S. Hagopian, V. Hagopian, K. F. Johnson, H. Prosper, V. Veeraraghavan, M. Weinberg, M. M. Baarmand, B. Dorney, M. Hohlmann, H. Kalakhety, F. Yumiceva, M. R. Adams, L. Apanasevich, V. E. Bazterra, R. R. Betts, I. Bucinskaite, J. Callner, R. Cavanaugh, O. Evdokimov, L. Gauthier, C. E. Gerber, D. J. Hofman, S. Khalatyan, P. Kurt, F. Lacroix, D. H. Moon, C. O’Brien, C. Silkworth, D. Strom, P. Turner, N. Varelas, U. Akgun, E. A. Albayrak, B. Bilki, W. Clarida, K. Dilsiz, F. Duru, S. Griffiths, J.-P. Merlo, H. Mermerkaya, A. Mestvirishvili, A. Moeller, J. Nachtman, C. R. Newsom, H. Ogul, Y. Onel, F. Ozok, S. Sen, P. Tan, E. Tiras, J. Wetzel, T. Yetkin, K. Yi, B. A. Barnett, B. Blumenfeld, S. Bolognesi, D. Fehling, G. Giurgiu, A. V. Gritsan, Z. J. Guo, G. Hu, P. Maksimovic, M. Swartz, A. Whitbeck, P. Baringer, A. Bean, G. Benelli, R. P. Kenny, M. Murray, D. Noonan, S. Sanders, R. Stringer, J. S. Wood, A. F. Barfuss, I. Chakaberia, A. Ivanov, S. Khalil, M. Makouski, Y. Maravin, S. Shrestha, I. Svintradze, J. Gronberg, D. Lange, F. Rebassoo, D. Wright, A. Baden, B. Calvert, S. C. Eno, J. A. Gomez, N. J. Hadley, R. G. Kellogg, T. Kolberg, Y. Lu, M. Marionneau, A. C. Mignerey, K. Pedro, A. Peterman, A. Skuja, J. Temple, M. B. Tonjes, S. C. Tonwar, A. Apyan, G. Bauer, W. Busza, E. Butz, I. A. Cali, M. Chan, V. Dutta, G. Gomez Ceballos, M. Goncharov, Y. Kim, M. Klute, Y. S. Lai, A. Levin, P. D. Luckey, T. Ma, S. Nahn, C. Paus, D. Ralph, C. Roland, G. Roland, G. S. F. Stephans, F. Stöckli, K. Sumorok, K. Sung, D. Velicanu, R. Wolf, B. Wyslouch, M. Yang, Y. Yilmaz, A. S. Yoon, M. Zanetti, V. Zhukova, B. Dahmes, A. De Benedetti, G. Franzoni, A. Gude, J. Haupt, S. C. Kao, K. Klapoetke, Y. Kubota, J. Mans, N. Pastika, R. Rusack, M. Sasseville, A. Singovsky, N. Tambe, J. Turkewitz, L. M. Cremaldi, R. Kroeger, L. Perera, R. Rahmat, D. A. Sanders, D. Summers, E. Avdeeva, K. Bloom, S. Bose, D. R. Claes, A. Dominguez, M. Eads, R. Gonzalez Suarez, J. Keller, I. Kravchenko, J. Lazo-Flores, S. Malik, F. Meier, G. R. Snow, J. Dolen, A. Godshalk, I. Iashvili, S. Jain, A. Kharchilava, A. Kumar, S. Rappoccio, Z. Wan, G. Alverson, E. Barberis, D. Baumgartel, M. Chasco, J. Haley, A. Massironi, D. Nash, T. Orimoto, D. Trocino, D. Wood, J. Zhang, A. Anastassov, K. A. Hahn, A. Kubik, L. Lusito, N. Mucia, N. Odell, B. Pollack, A. Pozdnyakov, M. Schmitt, S. Stoynev, M. Velasco, S. Won, D. Berry, A. Brinkerhoff, K. M. Chan, M. Hildreth, C. Jessop, D. J. Karmgard, J. Kolb, K. Lannon, W. Luo, S. Lynch, N. Marinelli, D. M. Morse, T. Pearson, M. Planer, R. Ruchti, J. Slaunwhite, N. Valls, M. Wayne, M. Wolf, L. Antonelli, B. Bylsma, L. S. Durkin, C. Hill, R. Hughes, K. Kotov, T. Y. Ling, D. Puigh, M. Rodenburg, G. Smith, C. Vuosalo, G. Williams, B. L. Winer, H. Wolfe, E. Berry, P. Elmer, V. Halyo, P. Hebda, J. Hegeman, A. Hunt, P. Jindal, S. A. Koay, D. Lopes Pegna, P. Lujan, D. Marlow, T. Medvedeva, M. Mooney, J. Olsen, P. Piroué, X. Quan, A. Raval, H. Saka, D. Stickland, C. Tully, J. S. Werner, S. C. Zenz, A. Zuranski, E. Brownson, A. Lopez, H. Mendez, J. E. Ramirez Vargas, E. Alagoz, D. Benedetti, G. Bolla, D. Bortoletto, M. De Mattia, A. Everett, Z. Hu, M. Jones, K. Jung, O. Koybasi, M. Kress, N. Leonardo, V. Maroussov, P. Merkel, D. H. Miller, N. Neumeister, I. Shipsey, D. Silvers, A. Svyatkovskiy, M. Vidal Marono, F. Wang, L. Xu, H. D. Yoo, J. Zablocki, Y. Zheng, S. Guragain, N. Parashar, A. Adair, B. Akgun, K. M. Ecklund, F. J. M. Geurts, B. P. Padley, R. Redjimi, J. Roberts, J. Zabel, B. Betchart, A. Bodek, R. Covarelli, P. de Barbaro, R. Demina, Y. Eshaq, T. Ferbel, A. Garcia-Bellido, P. Goldenzweig, J. Han, A. Harel, D. C. Miner, G. Petrillo, D. Vishnevskiy, M. Zielinski, A. Bhatti, R. Ciesielski, L. Demortier, K. Goulianos, G. Lungu, C. Mesropian, S. Arora, A. Barker, J. P. Chou, C. Contreras-Campana, E. Contreras-Campana, D. Duggan, D. Ferencek, Y. Gershtein, R. Gray, E. Halkiadakis, D. Hidas, A. Lath, S. Panwalkar, M. Park, R. Patel, V. Rekovic, J. Robles, K. Rose, S. Salur, S. Schnetzer, C. Seitz, S. Somalwar, R. Stone, S. Thomas, M. Walker, G. Cerizza, M. Hollingsworth, S. Spanier, Z. C. Yang, A. York, R. Eusebi, W. Flanagan, J. Gilmore, T. Kamon, V. Khotilovich, R. Montalvo, I. Osipenkov, Y. Pakhotin, A. Perloff, J. Roe, A. Safonov, T. Sakuma, I. Suarez, A. Tatarinov, D. Toback, N. Akchurin, J. Damgov, C. Dragoiu, P. R. Dudero, C. Jeong, K. Kovitanggoon, S. W. Lee, T. Libeiro, I. Volobouev, E. Appelt, A. G. Delannoy, S. Greene, A. Gurrola, W. Johns, C. Maguire, A. Melo, M. Sharma, P. Sheldon, B. Snook, S. Tuo, J. Velkovska, M. W. Arenton, S. Boutle, B. Cox, B. Francis, J. Goodell, R. Hirosky, A. Ledovskoy, C. Lin, C. Neu, J. Wood, S. Gollapinni, R. Harr, P. E. Karchin, C. Kottachchi Kankanamge Don, P. Lamichhane, A. Sakharov, M. Anderson, D. A. Belknap, L. Borrello, D. Carlsmith, M. Cepeda, S. Dasu, E. Friis, K. S. Grogg, M. Grothe, R. Hall-Wilton, M. Herndon, A. Hervé, K. Kaadze, P. Klabbers, J. Klukas, A. Lanaro, C. Lazaridis, R. Loveless, A. Mohapatra, M. U. Mozer, I. Ojalvo, G. A. Pierro, I. Ross, A. Savin, W. H. Smith, and J. Swanson

Subjects
Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2022
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113. The Effect of Macular Hole Duration on Surgical Outcomes: An Individual Participant Data Study of Randomized Controlled Trials

Author

Qu, Jinfeng, Zhao, Mingwei, Sadda, Srinivas, Manasa, Sreekumar, Agarwal, Divya, Kumar, Atul, Kakkar, Prateek, Bourgault, Serge, Tourville, Eric, Velez-Montoya, Raul, Hernandez-Da Mota, Sergio E., Ramirez-Estudillo, J. Abel, Nawrocki, Jerzy, Nawrocka, Zofia Anna, Lange, Clemens, Bainbridge, James, Yorston, David, Alberti, Mark, Cour, Morten la, Christensen, Ulrik, Ho Alvin, Kwok Kwan, Murphy, Declan C., Al-Zubaidy, Mo, Lois, Noemi, Scott, Neil, and Steel, David H.

Published
2023
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114. Invited review: Sensor technologies for real-time monitoring of the rumen environment

Author

Chan Su Han, Upinder Kaur, Huiwen Bai, Barbara Roqueto dos Reis, Robin White, Robert A. Nawrocki, Richard M. Voyles, Min Gyu Kang, and Shashank Priya

Subjects
biosensor, rumen, precision livestock farming, Dairy processing. Dairy products, SF250.5-275, Dairying, SF221-250
Abstract

ABSTRACT: Quantifying digestive and fermentative processes within the rumen environment has been the subject of decades of research; however, our existing research methodologies preclude time-sensitive and spatially explicit investigation of this system. To better understand the temporal and spatial dynamics of the rumen environment, real-time and in situ monitoring of various chemical and physical parameters in the rumen through implantable microsensor technologies is a practical solution. Moreover, such sensors could contribute to the next generation of precision livestock farming, provided sufficient wireless data networking and computing systems are incorporated. In this review, various microsensor technologies applicable to real-time metabolic monitoring for ruminants are introduced, including the detection of parameters for rumen metabolism, such as pH, temperature, histamine concentrations, and volatile fatty acid concentrations. The working mechanisms and requirements of the sensors are summarized with respect to the selected target parameters. Lastly, future challenges and perspectives of this research field are discussed.

Published
2022
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116. Erratum: Measurement of prompt and nonprompt charmonium suppression in PbPb collisions at 5.02 TeV

Author

Sirunyan, A. M., Tumasyan, A., Adam, W., Ambrogi, F., Asilar, E., Bergauer, T., Brandstetter, J., Brondolin, E., Dragicevic, M., Erö, J., Valle, A. Escalante Del, Flechl, M., Friedl, M., Frühwirth, R., Ghete, V. M., Grossmann, J., Hrubec, J., Jeitler, M., König, A., Krammer, N., Krätschmer, I., Liko, D., Madlener, T., Mikulec, I., Pree, E., Rad, N., Rohringer, H., Schieck, J., Schöfbeck, R., Spanring, M., Spitzbart, D., Waltenberger, W., Wittmann, J., Wulz, C.-E., Zarucki, M., Chekhovsky, V., Mossolov, V., Gonzalez, J. Suarez, De Wolf, E. A., Croce, D. Di, Janssen, X., Lauwers, J., De Klundert, M. Van, Haevermaet, H. Van, Mechelen, P. Van, Remortel, N. Van, Zeid, S. Abu, Blekman, F., D’Hondt, J., De Bruyn, I., De Clercq, J., Deroover, K., Flouris, G., Lontkovskyi, D., Lowette, S., Marchesini, I., Moortgat, S., Moreels, L., Python, Q., Skovpen, K., Tavernier, S., Doninck, W. Van, Mulders, P. Van, Parijs, I. Van, Beghin, D., Bilin, B., Brun, H., Clerbaux, B., De Lentdecker, G., Delannoy, H., Dorney, B., Fasanella, G., Favart, L., Goldouzian, R., Grebenyuk, A., Kalsi, A. K., Lenzi, T., Luetic, J., Maerschalk, T., Marinov, A., Seva, T., Starling, E., Velde, C. Vander, Vanlaer, P., Vannerom, D., Yonamine, R., Zenoni, F., Cornelis, T., Dobur, D., Fagot, A., Gul, M., Khvastunov, I., Poyraz, D., Roskas, C., Salva, S., Tytgat, M., Verbeke, W., Zaganidis, N., Bakhshiansohi, H., Bondu, O., Brochet, S., Bruno, G., Caputo, C., Caudron, A., David, P., De Visscher, S., Delaere, C., Delcourt, M., Francois, B., Giammanco, A., Komm, M., Krintiras, G., Lemaitre, V., Magitteri, A., Mertens, A., Musich, M., Piotrzkowski, K., Quertenmont, L., Saggio, A., Marono, M. Vidal, Wertz, S., Zobec, J., Júnior, W. L. Aldá, Alves, F. L., Alves, G. A., Brito, L., Junior, M. Correa Martins, Hensel, C., Moraes, A., Pol, M. E., Teles, P. Rebello, Chagas, E. Belchior Batista Das, Carvalho, W., Chinellato, J., Coelho, E., Da Costa, E. M., Da Silveira, G. G., De Jesus Damiao, D., De Souza, S. Fonseca, Guativa, L. M. Huertas, Malbouisson, H., De Almeida, M. Melo, Herrera, C. Mora, Mundim, L., Nogima, H., Rosas, L. J. Sanchez, Santoro, A., Sznajder, A., Thiel, M., Manganote, E. J. Tonelli, Da Silva De Araujo, F. Torres, Pereira, A. Vilela, Ahuja, S., Bernardes, C. A., Tomei, T. R. Fernandez Perez, Gregores, E. M., Mercadante, P. G., Novaes, S. F., Padula, Sandra S., Abad, D. Romero, Vargas, J. C. Ruiz, Aleksandrov, A., Hadjiiska, R., Iaydjiev, P., Misheva, M., Rodozov, M., Shopova, M., Sultanov, G., Dimitrov, A., Litov, L., Pavlov, B., Petkov, P., Fang, W., Gao, X., Yuan, L., Ahmad, M., Bian, J. G., Chen, G. M., Chen, H. S., Chen, M., Chen, Y., Jiang, C. H., Leggat, D., Liao, H., Liu, Z., Romeo, F., Shaheen, S. M., Spiezia, A., Tao, J., Wang, C., Wang, Z., Yazgan, E., Zhang, H., Zhang, S., Zhao, J., Ban, Y., Chen, G., Li, J., Li, Q., Liu, S., Mao, Y., Qian, S. J., Wang, D., Xu, Z., Zhang, F., Wang, Y., Avila, C., Cabrera, A., Montoya, C. A. Carrillo, Sierra, L. F. Chaparro, Florez, C., Hernández, C. F. González, Alvarez, J. D. Ruiz, Delgado, M. A. Segura, Courbon, B., Godinovic, N., Lelas, D., Puljak, I., Cipriano, P. M. Ribeiro, Sculac, T., Antunovic, Z., Kovac, M., Brigljevic, V., Ferencek, D., Kadija, K., Mesic, B., Starodumov, A., Susa, T., Ather, M. W., Attikis, A., Mavromanolakis, G., Mousa, J., Nicolaou, C., Ptochos, F., Razis, P. A., Rykaczewski, H., Finger, M., Finger, Jr., M., Jarrin, E. Carrera, Mahmoud, M. A., Mohammed, Y., Salama, E., Dewanjee, R. K., Kadastik, M., Perrini, L., Raidal, M., Tiko, A., Veelken, C., Eerola, P., Kirschenmann, H., Pekkanen, J., Voutilainen, M., Havukainen, J., Heikkilä, J. K., Järvinen, T., Karimäki, V., Kinnunen, R., Lampén, T., Lassila-Perini, K., Laurila, S., Lehti, S., Lindén, T., Luukka, P., Siikonen, H., Tuominen, E., Tuominiemi, J., Tuuva, T., Besancon, M., Couderc, F., Dejardin, M., Denegri, D., Faure, J. L., Ferri, F., Ganjour, S., Ghosh, S., Gras, P., de Monchenault, G. Hamel, Jarry, P., Kucher, I., Leloup, C., Locci, E., Machet, M., Malcles, J., Negro, G., Rander, J., Rosowsky, A., Sahin, M.Ö., Titov, M., Abdulsalam, A., Amendola, C., Antropov, I., Baffioni, S., Beaudette, F., Busson, P., Cadamuro, L., Charlot, C., de Cassagnac, R. Granier, Jo, M., Lisniak, S., Lobanov, A., Blanco, J. Martin, Nguyen, M., Ochando, C., Ortona, G., Paganini, P., Pigard, P., Salerno, R., Sauvan, J. B., Sirois, Y., Leiton, A. G. Stahl, Strebler, T., Yilmaz, Y., Zabi, A., Zghiche, A., Agram, J.-L., Andrea, J., Bloch, D., Brom, J.-M., Buttignol, M., Chabert, E. C., Chanon, N., Collard, C., Conte, E., Coubez, X., Fontaine, J.-C., Gelé, D., Goerlach, U., Jansová, M., Bihan, A.-C. Le, Tonon, N., Hove, P. Van, Gadrat, S., Beauceron, S., Bernet, C., Boudoul, G., Chierici, R., Contardo, D., Depasse, P., Mamouni, H. El, Fay, J., Finco, L., Gascon, S., Gouzevitch, M., Grenier, G., Ille, B., Lagarde, F., Laktineh, I. B., Lethuillier, M., Mirabito, L., Pequegnot, A. L., Perries, S., Popov, A., Sordini, V., Donckt, M. Vander, Viret, S., Toriashvili, T., Tsamalaidze, Z., Autermann, C., Feld, L., Kiesel, M. K., Klein, K., Lipinski, M., Preuten, M., Schomakers, C., Schulz, J., Teroerde, M., Zhukov, V., Albert, A., Dietz-Laursonn, E., Duchardt, D., Endres, M., Erdmann, M., Erdweg, S., Esch, T., Fischer, R., Güth, A., Hamer, M., Hebbeker, T., Heidemann, C., Hoepfner, K., Knutzen, S., Merschmeyer, M., Meyer, A., Millet, P., Mukherjee, S., Pook, T., Radziej, M., Reithler, H., Rieger, M., Scheuch, F., Teyssier, D., Thüer, S., Flügge, G., Kargoll, B., Kress, T., Künsken, A., Müller, T., Nehrkorn, A., Nowack, A., Pistone, C., Pooth, O., Stahl, A., Martin, M. Aldaya, Arndt, T., Asawatangtrakuldee, C., Beernaert, K., Behnke, O., Behrens, U., Martínez, A. Bermúdez, Anuar, A. A. Bin, Borras, K., Botta, V., Campbell, A., Connor, P., Contreras-Campana, C., Costanza, F., Pardos, C. Diez, Eckerlin, G., Eckstein, D., Eichhorn, T., Eren, E., Gallo, E., Garcia, J. Garay, Geiser, A., Luyando, J. M. Grados, Grohsjean, A., Gunnellini, P., Guthoff, M., Harb, A., Hauk, J., Hempel, M., Jung, H., Kasemann, M., Keaveney, J., Kleinwort, C., Korol, I., Krücker, D., Lange, W., Lelek, A., Lenz, T., Leonard, J., Lipka, K., Lohmann, W., Mankel, R., Melzer-Pellmann, I.-A., Meyer, A. B., Mittag, G., Mnich, J., Mussgiller, A., Ntomari, E., Pitzl, D., Raspereza, A., Savitskyi, M., Saxena, P., Shevchenko, R., Stefaniuk, N., Onsem, G. P. Van, Walsh, R., Wen, Y., Wichmann, K., Wissing, C., Zenaiev, O., Aggleton, R., Bein, S., Blobel, V., Vignali, M. Centis, Dreyer, T., Garutti, E., Gonzalez, D., Haller, J., Hinzmann, A., Hoffmann, M., Karavdina, A., Klanner, R., Kogler, R., Kovalchuk, N., Kurz, S., Lapsien, T., Marconi, D., Meyer, M., Niedziela, M., Nowatschin, D., Pantaleo, F., Peiffer, T., Perieanu, A., Scharf, C., Schleper, P., Schmidt, A., Schumann, S., Schwandt, J., Sonneveld, J., Stadie, H., Steinbrück, G., Stober, F. M., Stöver, M., Tholen, H., Troendle, D., Usai, E., Vanhoefer, A., Vormwald, B., Akbiyik, M., Barth, C., Baselga, M., Baur, S., Butz, E., Caspart, R., Chwalek, T., Colombo, F., De Boer, W., Dierlamm, A., Faltermann, N., Freund, B., Friese, R., Giffels, M., Harrendorf, M. A., Hartmann, F., Heindl, S. M., Husemann, U., Kassel, F., Kudella, S., Mildner, H., Mozer, M. U., Müller, Th., Plagge, M., Quast, G., Rabbertz, K., Schröder, M., Shvetsov, I., Sieber, G., Simonis, H. J., Ulrich, R., Wayand, S., Weber, M., Weiler, T., Williamson, S., Wöhrmann, C., Wolf, R., Anagnostou, G., Daskalakis, G., Geralis, T., Kyriakis, A., Loukas, D., Topsis-Giotis, I., Karathanasis, G., Kesisoglou, S., Panagiotou, A., Saoulidou, N., Kousouris, K., Evangelou, I., Foudas, C., Gianneios, P., Katsoulis, P., Kokkas, P., Mallios, S., Manthos, N., Papadopoulos, I., Paradas, E., Strologas, J., Triantis, F. A., Tsitsonis, D., Csanad, M., Filipovic, N., Pasztor, G., Surányi, O., Veres, G. I., Bencze, G., Hajdu, C., Horvath, D., Hunyadi, Á., Sikler, F., Veszpremi, V., Beni, N., Czellar, S., Karancsi, J., Makovec, A., Molnar, J., Szillasi, Z., Bartók, M., Raics, P., Trocsanyi, Z. L., Ujvari, B., Choudhury, S., Komaragiri, J. R., Bahinipati, S., Bhowmik, S., Mal, P., Mandal, K., Nayak, A., Sahoo, D. K., Sahoo, N., Swain, S. K., Bansal, S., Beri, S. B., Bhatnagar, V., Chawla, R., Dhingra, N., Kaur, A., Kaur, M., Kaur, S., Kumar, R., Kumari, P., Mehta, A., Singh, J. B., Walia, G., Kumar, Ashok, Shah, Aashaq, Bhardwaj, A., Chauhan, S., Choudhary, B. C., Garg, R. B., Keshri, S., Kumar, A., Malhotra, S., Naimuddin, M., Ranjan, K., Sharma, R., Bhardwaj, R., Bhattacharya, R., Bhattacharya, S., Bhawandeep, U., Dey, S., Dutt, S., Dutta, S., Ghosh, S., Majumdar, N., Modak, A., Mondal, K., Mukhopadhyay, S., Nandan, S., Purohit, A., Roy, A., Chowdhury, S. Roy, Sarkar, S., Sharan, M., Thakur, S., Behera, P. K., Chudasama, R., Dutta, D., Jha, V., Kumar, V., Mohanty, A. K., Netrakanti, P. K., Pant, L. M., Shukla, P., Topkar, A., Aziz, T., Dugad, S., Mahakud, B., Mitra, S., Mohanty, G. B., Sur, N., Sutar, B., Banerjee, S., Bhattacharya, S., Chatterjee, S., Das, P., Guchait, M., Jain, Sa., Kumar, S., Maity, M., Majumder, G., Mazumdar, K., Sarkar, T., Wickramage, N., Chauhan, S., Dube, S., Hegde, V., Kapoor, A., Kothekar, K., Pandey, S., Rane, A., Sharma, S., Chenarani, S., Tadavani, E. Eskandari, Etesami, S. M., Khakzad, M., Najafabadi, M. Mohammadi, Naseri, M., Mehdiabadi, S. Paktinat, Hosseinabadi, F. Rezaei, Safarzadeh, B., Zeinali, M., Felcini, M., Grunewald, M., Abbrescia, M., Calabria, C., Colaleo, A., Creanza, D., Cristella, L., De Filippis, N., De Palma, M., Errico, F., Fiore, L., Iaselli, G., Lezki, S., Maggi, G., Maggi, M., Miniello, G., My, S., Nuzzo, S., Pompili, A., Pugliese, G., Radogna, R., Ranieri, A., Selvaggi, G., Sharma, A., Silvestris, L., Venditti, R., Verwilligen, P., Abbiendi, G., Battilana, C., Bonacorsi, D., Borgonovi, L., Braibant-Giacomelli, S., Campanini, R., Capiluppi, P., Castro, A., Cavallo, F. R., Chhibra, S. S., Codispoti, G., Cuffiani, M., Dallavalle, G. M., Fabbri, F., Fanfani, A., Fasanella, D., Giacomelli, P., Grandi, C., Guiducci, L., Marcellini, S., Masetti, G., Montanari, A., Navarria, F. L., Perrotta, A., Rossi, A. M., Rovelli, T., Siroli, G. P., Tosi, N., Albergo, S., Costa, S., Mattia, A. Di, Giordano, F., Potenza, R., Tricomi, A., Tuve, C., Barbagli, G., Chatterjee, K., Ciulli, V., Civinini, C., D’Alessandro, R., Focardi, E., Lenzi, P., Meschini, M., Paoletti, S., Russo, L., Sguazzoni, G., Strom, D., Viliani, L., Benussi, L., Bianco, S., Fabbri, F., Piccolo, D., Primavera, F., Calvelli, V., Ferro, F., Ravera, F., Robutti, E., Tosi, S., Benaglia, A., Beschi, A., Brianza, L., Brivio, F., Ciriolo, V., Dinardo, M. E., Fiorendi, S., Gennai, S., Ghezzi, A., Govoni, P., Malberti, M., Malvezzi, S., Manzoni, R. A., Menasce, D., Moroni, L., Paganoni, M., Pauwels, K., Pedrini, D., Pigazzini, S., Ragazzi, S., de Fatis, T. Tabarelli, Buontempo, S., Cavallo, N., Guida, S. Di, Fabozzi, F., Fienga, F., Iorio, A. O. M., Khan, W. A., Lista, L., Meola, S., Paolucci, P., Sciacca, C., Thyssen, F., Azzi, P., Bacchetta, N., Benato, L., Bisello, D., Boletti, A., Carlin, R., De Oliveira, A. Carvalho Antunes, Checchia, P., Dall’Osso, M., De Castro Manzano, P., Dorigo, T., Gasparini, F., Gasparini, U., Gozzelino, A., Lacaprara, S., Lujan, P., Margoni, M., Meneguzzo, A. T., Pozzobon, N., Ronchese, P., Rossin, R., Simonetto, F., Torassa, E., Ventura, S., Zanetti, M., Zotto, P., Braghieri, A., Magnani, A., Montagna, P., Ratti, S. P., Re, V., Ressegotti, M., Riccardi, C., Salvini, P., Vai, I., Vitulo, P., Solestizi, L. Alunni, Biasini, M., Bilei, G. M., Cecchi, C., Ciangottini, D., Fanò, L., Leonardi, R., Manoni, E., Mantovani, G., Mariani, V., Menichelli, M., Rossi, A., Santocchia, A., Spiga, D., Androsov, K., Azzurri, P., Bagliesi, G., Boccali, T., Borrello, L., Castaldi, R., Ciocci, M. A., Dell’Orso, R., Fedi, G., Giannini, L., Giassi, A., Grippo, M. T., Ligabue, F., Lomtadze, T., Manca, E., Mandorli, G., Messineo, A., Palla, F., Rizzi, A., Savoy-Navarro, A., Spagnolo, P., Tenchini, R., Tonelli, G., Venturi, A., Verdini, P. G., Barone, L., Cavallari, F., Cipriani, M., Daci, N., Re, D. Del, Marco, E. Di, Diemoz, M., Gelli, S., Longo, E., Margaroli, F., Marzocchi, B., Meridiani, P., Organtini, G., Paramatti, R., Preiato, F., Rahatlou, S., Rovelli, C., Santanastasio, F., Amapane, N., Arcidiacono, R., Argiro, S., Arneodo, M., Bartosik, N., Bellan, R., Biino, C., Cartiglia, N., Cenna, F., Costa, M., Covarelli, R., Degano, A., Demaria, N., Kiani, B., Mariotti, C., Maselli, S., Migliore, E., Monaco, V., Monteil, E., Monteno, M., Obertino, M. M., Pacher, L., Pastrone, N., Pelliccioni, M., Angioni, G. L. Pinna, Romero, A., Ruspa, M., Sacchi, R., Shchelina, K., Sola, V., Solano, A., Staiano, A., Traczyk, P., Belforte, S., Casarsa, M., Cossutti, F., Ricca, G. Della, Zanetti, A., Kim, D. H., Kim, G. N., Kim, M. S., Lee, J., Lee, S., Lee, S. W., Moon, C. S., Oh, Y. D., Sekmen, S., Son, D. C., Yang, Y. C., Lee, A., Kim, H., Moon, D. H., Oh, G., Cifuentes, J. A. Brochero, Goh, J., Kim, T. J., Cho, S., Choi, S., Go, Y., Gyun, D., Ha, S., Hong, B., Jo, Y., Kim, Y., Lee, K., Lee, K. S., Lee, S., Lim, J., Park, S. K., Roh, Y., Almond, J., Kim, J., Kim, J. S., Lee, H., Lee, K., Nam, K., Oh, S. B., Radburn-Smith, B. C., Seo, S. H., Yang, U. K., Yoo, H. D., Yu, G. B., Kim, H., Kim, J. H., Lee, J. S. H., Park, I. C., Choi, Y., Hwang, C., Lee, J., Yu, I., Dudenas, V., Juodagalvis, A., Vaitkus, J., Ahmed, I., Ibrahim, Z. A., Ali, M. A. B. Md, Idris, F. Mohamad, Abdullah, W. A. T. Wan, Yusli, M. N., Zolkapli, Z., Reyes-Almanza, R., Ramirez-Sanchez, G., Duran-Osuna, M. C., Castilla-Valdez, H., De La Cruz-Burelo, E., La Cruz, I. Heredia-De, Rabadan-Trejo, R. I., Lopez-Fernandez, R., Mejia Guisao, J., Sanchez-Hernandez, A., Moreno, S. Carrillo, Barrera, C. Oropeza, Valencia, F. Vazquez, Eysermans, J., Pedraza, I., Ibarguen, H. A. Salazar, Estrada, C. Uribe, Pineda, A. Morelos, Krofcheck, D., Butler, P. H., Ahmad, A., Ahmad, M., Hassan, Q., Hoorani, H. R., Saddique, A., Shah, M. A., Shoaib, M., Waqas, M., Bialkowska, H., Bluj, M., Boimska, B., Frueboes, T., Górski, M., Kazana, M., Nawrocki, K., Szleper, M., Zalewski, P., Bunkowski, K., Byszuk, A., Doroba, K., Kalinowski, A., Konecki, M., Krolikowski, J., Misiura, M., Olszewski, M., Pyskir, A., Walczak, M., Bargassa, P., Da Cruz E Silva, C. Beirão, Francesco, A. Di, Faccioli, P., Galinhas, B., Gallinaro, M., Hollar, J., Leonardo, N., Iglesias, L. Lloret, Nemallapudi, M. V., Seixas, J., Strong, G., Toldaiev, O., Vadruccio, D., Varela, J., Baginyan, A., Golunov, A., Golutvin, I., Karjavin, V., Korenkov, V., Kozlov, G., Lanev, A., Malakhov, A., Matveev, V., Mitsyn, V. V., Palichik, V., Perelygin, V., Shmatov, S., Skatchkov, N., Smirnov, V., Yuldashev, B. S., Zarubin, A., Zhiltsov, V., Ivanov, Y., Kim, V., Kuznetsova, E., Levchenko, P., Murzin, V., Oreshkin, V., Smirnov, I., Sosnov, D., Sulimov, V., Uvarov, L., Vavilov, S., Vorobyev, A., Andreev, Yu., Dermenev, A., Gninenko, S., Golubev, N., Karneyeu, A., Kirsanov, M., Krasnikov, N., Pashenkov, A., Tlisov, D., Toropin, A., Epshteyn, V., Gavrilov, V., Lychkovskaya, N., Popov, V., Pozdnyakov, I., Safronov, G., Spiridonov, A., Stepennov, A., Toms, M., Vlasov, E., Zhokin, A., Aushev, T., Bylinkin, A., Chadeeva, M., Parygin, P., Philippov, D., Polikarpov, S., Popova, E., Rusinov, V., Andreev, V., Azarkin, M., Dremin, I., Kirakosyan, M., Terkulov, A., Baskakov, A., Belyaev, A., Boos, E., Demiyanov, A., Ershov, A., Gribushin, A., Kodolova, O., Korotkikh, V., Lokhtin, I., Miagkov, I., Obraztsov, S., Petrushanko, S., Savrin, V., Snigirev, A., Vardanyan, I., Blinov, V., Shtol, D., Skovpen, Y., Azhgirey, I., Bayshev, I., Bitioukov, S., Elumakhov, D., Godizov, A., Kachanov, V., Kalinin, A., Konstantinov, D., Mandrik, P., Petrov, V., Ryutin, R., Sobol, A., Troshin, S., Tyurin, N., Uzunian, A., Volkov, A., Adzic, P., Cirkovic, P., Devetak, D., Dordevic, M., Milosevic, J., Rekovic, V., Maestre, J. Alcaraz, Fernández, A. Álvarez, Bachiller, I., Luna, M. Barrio, Cerrada, M., Colino, N., De La Cruz, B., Peris, A. Delgado, Bedoya, C. Fernandez, Ramos, J. P. Fernández, Flix, J., Fouz, M. C., Lopez, O. Gonzalez, Lopez, S. Goy, Hernandez, J. M., Josa, M. I., Moran, D., Yzquierdo, A. Pérez-Calero, Pelayo, J. Puerta, Olmeda, A. Quintario, Redondo, I., Romero, L., Soares, M. S., Albajar, C., de Trocóniz, J. F., Missiroli, M., Cuevas, J., Erice, C., Menendez, J. Fernandez, Caballero, I. Gonzalez, Fernández, J. R. González, Cortezon, E. Palencia, Cruz, S. Sanchez, Vischia, P., Garcia, J. M. Vizan, Cabrillo, I. J., Calderon, A., Quero, B. Chazin, Curras, E., Campderros, J. Duarte, Fernandez, M., Garcia-Ferrero, J., Gomez, G., Virto, A. Lopez, Marco, J., Rivero, C. Martinez, Arbol, P. Martinez Ruiz del, Matorras, F., Gomez, J. Piedra, Rodrigo, T., Ruiz-Jimeno, A., Scodellaro, L., Trevisani, N., Vila, I., Cortabitarte, R. Vilar, Abbaneo, D., Akgun, B., Auffray, E., Baillon, P., Ball, A. H., Barney, D., Bendavid, J., Bianco, M., Bloch, P., Bocci, A., Botta, C., Camporesi, T., Castello, R., Cepeda, M., Cerminara, G., Chapon, E., Chen, Y., d’Enterria, D., Dabrowski, A., Daponte, V., David, A., De Gruttola, M., De Roeck, A., Deelen, N., Dobson, M., Pree, T. du, Dünser, M., Dupont, N., Elliott-Peisert, A., Everaerts, P., Fallavollita, F., Franzoni, G., Fulcher, J., Funk, W., Gigi, D., Gilbert, A., Gill, K., Glege, F., Gulhan, D., Harris, P., Hegeman, J., Innocente, V., Jafari, A., Janot, P., Karacheban, O., Kieseler, J., Knünz, V., Kornmayer, A., Kortelainen, M. J., Krammer, M., Lange, C., Lecoq, P., Lourenço, C., Lucchini, M. T., Malgeri, L., Mannelli, M., Martelli, A., Meijers, F., Merlin, J. A., Mersi, S., Meschi, E., Milenovic, P., Moortgat, F., Mulders, M., Neugebauer, H., Ngadiuba, J., Orfanelli, S., Orsini, L., Pape, L., Perez, E., Peruzzi, M., Petrilli, A., Petrucciani, G., Pfeiffer, A., Pierini, M., Rabady, D., Racz, A., Reis, T., Rolandi, G., Rovere, M., Sakulin, H., Schäfer, C., Schwick, C., Seidel, M., Selvaggi, M., Sharma, A., Silva, P., Sphicas, P., Stakia, A., Steggemann, J., Stoye, M., Tosi, M., Treille, D., Triossi, A., Tsirou, A., Veckalns, V., Verweij, M., Zeuner, W. D., Bertl, W., Caminada, L., Deiters, K., Erdmann, W., Horisberger, R., Ingram, Q., Kaestli, H. C., Kotlinski, D., Langenegger, U., Rohe, T., Wiederkehr, S. A., Backhaus, M., Bäni, L., Berger, P., Bianchini, L., Casal, B., Dissertori, G., Dittmar, M., Donegà, M., Dorfer, C., Grab, C., Heidegger, C., Hits, D., Hoss, J., Kasieczka, G., Klijnsma, T., Lustermann, W., Mangano, B., Marionneau, M., Meinhard, M. 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M., Mason, D., McBride, P., Merkel, P., Mrenna, S., Nahn, S., O’Dell, V., Pedro, K., Prokofyev, O., Rakness, G., Ristori, L., Schneider, B., Sexton-Kennedy, E., Soha, A., Spalding, W. J., Spiegel, L., Stoynev, S., Strait, J., Strobbe, N., Taylor, L., Tkaczyk, S., Tran, N. V., Uplegger, L., Vaandering, E. W., Vernieri, C., Verzocchi, M., Vidal, R., Wang, M., Weber, H. A., Whitbeck, A., Acosta, D., Avery, P., Bortignon, P., Bourilkov, D., Brinkerhoff, A., Carnes, A., Carver, M., Curry, D., Field, R. D., Furic, I. K., Gleyzer, S. V., Joshi, B. M., Konigsberg, J., Korytov, A., Kotov, K., Ma, P., Matchev, K., Mei, H., Mitselmakher, G., Shi, K., Sperka, D., Terentyev, N., Thomas, L., Wang, J., Wang, S., Yelton, J., Joshi, Y. R., Linn, S., Markowitz, P., Rodriguez, J. L., Ackert, A., Adams, T., Askew, A., Hagopian, S., Hagopian, V., Johnson, K. F., Kolberg, T., Martinez, G., Perry, T., Prosper, H., Saha, A., Santra, A., Sharma, V., Yohay, R., Baarmand, M. M., Bhopatkar, V., Colafranceschi, S., Hohlmann, M., Noonan, D., Roy, T., Yumiceva, F., Adams, M. R., Apanasevich, L., Berry, D., Betts, R. R., Cavanaugh, R., Chen, X., Evdokimov, O., Gerber, C. E., Hangal, D. A., Hofman, D. J., Jung, K., Kamin, J., Gonzalez, I. D. Sandoval, Tonjes, M. B., Trauger, H., Varelas, N., Wang, H., Wu, Z., Zhang, J., Bilki, B., Clarida, W., Dilsiz, K., Durgut, S., Gandrajula, R. P., Haytmyradov, M., Khristenko, V., Merlo, J.-P., Mermerkaya, H., Mestvirishvili, A., Moeller, A., Nachtman, J., Ogul, H., Onel, Y., Ozok, F., Penzo, A., Snyder, C., Tiras, E., Wetzel, J., Yi, K., Blumenfeld, B., Cocoros, A., Eminizer, N., Fehling, D., Feng, L., Gritsan, A. V., Maksimovic, P., Roskes, J., Sarica, U., Swartz, M., Xiao, M., You, C., Al-bataineh, A., Baringer, P., Bean, A., Boren, S., Bowen, J., Castle, J., Khalil, S., Kropivnitskaya, A., Majumder, D., Mcbrayer, W., Murray, M., Royon, C., Sanders, S., Schmitz, E., Takaki, J. D. Tapia, Wang, Q., Ivanov, A., Kaadze, K., Maravin, Y., Mohammadi, A., Saini, L. K., Skhirtladze, N., Rebassoo, F., Wright, D., Anelli, C., Baden, A., Baron, O., Belloni, A., Eno, S. C., Feng, Y., Ferraioli, C., Hadley, N. J., Jabeen, S., Jeng, G. Y., Kellogg, R. G., Kunkle, J., Mignerey, A. C., Ricci-Tam, F., Shin, Y. H., Skuja, A., Tonwar, S. C., Abercrombie, D., Allen, B., Azzolini, V., Barbieri, R., Baty, A., Bi, R., Brandt, S., Busza, W., Cali, I. A., D’Alfonso, M., Demiragli, Z., Ceballos, G. Gomez, Goncharov, M., Hsu, D., Hu, M., Iiyama, Y., Innocenti, G. M., Klute, M., Kovalskyi, D., Lee, Y.-J., Levin, A., Luckey, P. D., Maier, B., Marini, A. C., Mcginn, C., Mironov, C., Narayanan, S., Niu, X., Paus, C., Roland, C., Roland, G., Salfeld-Nebgen, J., Stephans, G. S. F., Tatar, K., Velicanu, D., Wang, J., Wang, T. W., Wyslouch, B., Benvenuti, A. C., Chatterjee, R. M., Evans, A., Hansen, P., Hiltbrand, J., Kalafut, S., Kubota, Y., Lesko, Z., Mans, J., Nourbakhsh, S., Ruckstuhl, N., Rusack, R., Turkewitz, J., Wadud, M. A., Acosta, J. G., Oliveros, S., Avdeeva, E., Bloom, K., Claes, D. R., Fangmeier, C., Golf, F., Suarez, R. Gonzalez, Kamalieddin, R., Kravchenko, I., Monroy, J., Siado, J. E., Snow, G. R., Stieger, B., Dolen, J., Godshalk, A., Harrington, C., Iashvili, I., Nguyen, D., Parker, A., Rappoccio, S., Roozbahani, B., Alverson, G., Barberis, E., Freer, C., Hortiangtham, A., Massironi, A., Morse, D. M., Orimoto, T., De Lima, R. Teixeira, Trocino, D., Wamorkar, T., Wang, B., Wisecarver, A., Wood, D., Bhattacharya, S., Charaf, O., Hahn, K. A., Mucia, N., Odell, N., Schmitt, M. H., Sung, K., Trovato, M., Velasco, M., Bucci, R., Dev, N., Hildreth, M., Anampa, K. Hurtado, Jessop, C., Karmgard, D. J., Kellams, N., Lannon, K., Li, W., Loukas, N., Marinelli, N., Meng, F., Mueller, C., Musienko, Y., Planer, M., Reinsvold, A., Ruchti, R., Siddireddy, P., Smith, G., Taroni, S., Wayne, M., Wightman, A., Wolf, M., Woodard, A., Alimena, J., Antonelli, L., Bylsma, B., Durkin, L. S., Flowers, S., Francis, B., Hart, A., Hill, C., Ji, W., Liu, B., Luo, W., Winer, B. L., Wulsin, H. W., Cooperstein, S., Driga, O., Elmer, P., Hardenbrook, J., Hebda, P., Higginbotham, S., Kalogeropoulos, A., Lange, D., Luo, J., Marlow, D., Mei, K., Ojalvo, I., Olsen, J., Palmer, C., Piroué, P., Stickland, D., Tully, C., Malik, S., Norberg, S., Barker, A., Barnes, V. E., Das, S., Folgueras, S., Gutay, L., Jha, M. K., Jones, M., Jung, A. W., Khatiwada, A., Miller, D. H., Neumeister, N., Peng, C. C., Qiu, H., Schulte, J. F., Sun, J., Wang, F., Xiao, R., Xie, W., Cheng, T., Parashar, N., Stupak, J., Chen, Z., Ecklund, K. M., Freed, S., Geurts, F. J. M., Guilbaud, M., Kilpatrick, M., Li, W., Michlin, B., Padley, B. P., Roberts, J., Rorie, J., Shi, W., Tu, Z., Zabel, J., Zhang, A., Bodek, A., de Barbaro, P., Demina, R., Duh, Y. t., Ferbel, T., Galanti, M., Garcia-Bellido, A., Han, J., Hindrichs, O., Khukhunaishvili, A., Lo, K. H., Tan, P., Verzetti, M., Ciesielski, R., Goulianos, K., Mesropian, C., Agapitos, A., Chou, J. P., Gershtein, Y., Espinosa, T. A. Gómez, Halkiadakis, E., Heindl, M., Hughes, E., Kaplan, S., Elayavalli, R. Kunnawalkam, Kyriacou, S., Lath, A., Montalvo, R., Nash, K., Osherson, M., Saka, H., Salur, S., Schnetzer, S., Sheffield, D., Somalwar, S., Stone, R., Thomas, S., Thomassen, P., Walker, M., Delannoy, A. G., Heideman, J., Riley, G., Rose, K., Spanier, S., Thapa, K., Bouhali, O., Hernandez, A. Castaneda, Celik, A., Dalchenko, M., De Mattia, M., Delgado, A., Dildick, S., Eusebi, R., Gilmore, J., Huang, T., Kamon, T., Mueller, R., Pakhotin, Y., Patel, R., Perloff, A., Perniè, L., Rathjens, D., Safonov, A., Tatarinov, A., Ulmer, K. A., Akchurin, N., Damgov, J., De Guio, F., Dudero, P. R., Faulkner, J., Gurpinar, E., Kunori, S., Lamichhane, K., Lee, S. W., Libeiro, T., Mengke, T., Muthumuni, S., Peltola, T., Undleeb, S., Volobouev, I., Wang, Z., Greene, S., Gurrola, A., Janjam, R., Johns, W., Maguire, C., Melo, A., Ni, H., Padeken, K., Sheldon, P., Tuo, S., Velkovska, J., Xu, Q., Arenton, M. W., Barria, P., Cox, B., Hirosky, R., Joyce, M., Ledovskoy, A., Li, H., Neu, C., Sinthuprasith, T., Wang, Y., Wolfe, E., Xia, F., Harr, R., Karchin, P. E., Poudyal, N., Sturdy, J., Thapa, P., Zaleski, S., Brodski, M., Buchanan, J., Caillol, C., Dasu, S., Dodd, L., Duric, S., Gomber, B., Grothe, M., Herndon, M., Hervé, A., Hussain, U., Klabbers, P., Lanaro, A., Levine, A., Long, K., Loveless, R., Ruggles, T., Savin, A., Smith, N., Smith, W. H., Taylor, D., and Woods, N.

Published
2023
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118. Pan AMPK Activation Protects Tubules in Rat Ischemic Acute Kidney Injury

Author

Frikke-Schmidt, Henriette, primary, Albarazanji, Kamal, additional, Qi, Jenson, additional, Frederick, David, additional, Steffen, Janos, additional, Kalyana-Sundaram, Shanker, additional, Meng, Rong, additional, Devine, Zheng Huang, additional, Chen, Tao, additional, Li, Qiu, additional, Du, Fuyong, additional, Ho, George, additional, Liu, Jianying, additional, Riley, Roseann, additional, Gonzalez-Villalobos, Romer A, additional, Camacho, Raul C, additional, Nawrocki, Andrea R, additional, Pryor, Meghan, additional, Lee, Min, additional, Wong, Victoria, additional, Matico, Rosalie, additional, Diaz, Elsie, additional, Krosky, Daniel, additional, Wall, Mark, additional, Gao, Elise, additional, Shah, Akshay A, additional, Leonard, James, additional, Erion, Mark, additional, Pocai, Alessandro, additional, and Player, Mark R, additional

Published
2024
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119. The Determination of Free Energy of Hydration of Water Ions from First Principles

Author

Butin, Oleg, primary, Pereyaslavets, Leonid, additional, Kamath, Ganesh, additional, Illarionov, Alexey, additional, Sakipov, Serzhan, additional, Kurnikov, Igor V., additional, Voronina, Ekaterina, additional, Ivahnenko, Ilya, additional, Leontyev, Igor, additional, Nawrocki, Grzegorz, additional, Darkhovskiy, Mikhail, additional, Olevanov, Michael, additional, Cherniavskyi, Yevhen K., additional, Lock, Christopher, additional, Greenslade, Sean, additional, Kornberg, Roger D., additional, Levitt, Michael, additional, and Fain, Boris, additional

Published
2024
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121. Soluble biomarkers to predict clinical outcomes in non-small cell lung cancer treated by immune checkpoints inhibitors

Author

Julien Ancel, Valérian Dormoy, Béatrice Nawrocki Raby, Véronique Dalstein, Anne Durlach, Maxime Dewolf, Christine Gilles, Myriam Polette, and Gaëtan Deslée

Subjects
liquid biopsy, soluble biomarkers, immunotherapy, non-small cell lung cancer (NSCLC), neutrophil lymphocyte ratio (NLR), circulating tumor (ctDNA), Immunologic diseases. Allergy, RC581-607
Abstract

Lung cancer remains the first cause of cancer-related death despite many therapeutic innovations, including immune checkpoint inhibitors (ICI). ICI are now well used in daily practice at late metastatic stages and locally advanced stages after a chemo-radiation. ICI are also emerging in the peri-operative context. However, all patients do not benefit from ICI and even suffer from additional immune side effects. A current challenge remains to identify patients eligible for ICI and benefiting from these drugs. Currently, the prediction of ICI response is only supported by Programmed death-ligand 1 (PD-L1) tumor expression with perfectible results and limitations inherent to tumor-biopsy specimen analysis. Here, we reviewed alternative markers based on liquid biopsy and focused on the most promising biomarkers to modify clinical practice, including non-tumoral blood cell count such as absolute neutrophil counts, platelet to lymphocyte ratio, neutrophil to lymphocyte ratio, and derived neutrophil to lymphocyte ratio. We also discussed soluble-derived immune checkpoint-related products such as sPD-L1, circulating tumor cells (detection, count, and marker expression), and circulating tumor DNA-related products. Finally, we explored perspectives for liquid biopsies in the immune landscape and discussed how they could be implemented into lung cancer management with a potential biological–driven decision.

Published
2023
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125. Angiotensin-(1-5) is a Potent Endogenous Angiotensin AT2-Receptor Agonist

Author

Souza-Silva, Igor Maciel, primary, Peluso, A Augusto, additional, Elsaafien, Khalid, additional, Nazarova, Antonina L, additional, Assersen, Kasper B, additional, Rodrigues-Ribeiro, Lucas, additional, Mohammed, Mazher, additional, Rodrigues, André F., additional, Nawrocki, Arkadiusz, additional, Johansen, Lene A, additional, Jensen, Pia, additional, de Kloet, Annette D., additional, Krause, Eric G, additional, DelBorgo, Mark, additional, Maslov, Ivan, additional, Widdop, Robert E., additional, Santos, Robson Augusto Souza, additional, Bader, Michael, additional, Larsen, Martin Røssel, additional, Verano-Braga, Thiago, additional, Katritch, Vsevolod, additional, Sumners, Colin, additional, and Steckelings, Ulrike Muscha, additional

Published
2024
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127. Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis

Author

Xinkang Wang, Qiu Li, Fuyong Du, Neetu Shukla, Andrea R. Nawrocki, and Madhu Chintala

Subjects
anticoagulants, factor xi, thrombosis, models, animal, pharmacology, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Factor XIa (FXIa) is an emerging therapeutic target, and FXIa inhibition is a promising mechanism to improve therapeutic index over current anticoagulants. Milvexian (BMS-986177/JNJ-70033093) is an oral small-molecule FXIa inhibitor. Objective Milvexian's antithrombotic efficacy was characterized in a rabbit arteriovenous (AV) shunt model of venous thrombosis and compared with the factor Xa inhibitor apixaban and the direct thrombin inhibitor dabigatran. Methods The AV shunt model of thrombosis was conducted in anesthetized rabbits. Vehicle or drugs were administered as intravenous bolus plus a continuous infusion. Thrombus weight was the primary efficacy endpoint. Ex vivo activated partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin time (TT) were measured as the pharmacodynamic responses. Results Milvexian dose dependently reduced thrombus weights by 34.3 ± 7.9, 51.6 ± 6.8 (p

Published
2023
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130. Current Landscape of Immune Checkpoint Inhibitors for Metastatic Urothelial Carcinoma: Is There a Role for Additional T-Cell Blockade?

Author

Vanessa Ogbuji, Irasema C. Paster, Alejandro Recio-Boiles, Jennifer S. Carew, Steffan T. Nawrocki, and Juan Chipollini

Subjects
urothelial carcinoma, immune checkpoint inhibitor, bladder cancer, PD-1, CTLA-4, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Urothelial carcinoma (UC) is the most common form of bladder cancer (BC) and is the variant with the most immunogenic response. This makes urothelial carcinoma an ideal candidate for immunotherapy with immune checkpoint inhibitors. Key immune checkpoint proteins PD-1 and CTLA-4 are frequently expressed on T-cells in urothelial carcinoma. The blockade of this immune checkpoint can lead to the reactivation of lymphocytes and augment the anti-tumor immune response. The only immune checkpoint inhibitors that are FDA-approved for metastatic urothelial carcinoma target the programmed death-1 receptor and its ligand (PD-1/PD-L1) axis. However, the overall response rate and progression-free survival rates of these agents are limited in this patient population. Therefore, there is a need to find further immune-bolstering treatment combinations that may positively impact survival for patients with advanced UC. In this review, the current immune checkpoint inhibition treatment landscape is explored with an emphasis on combination therapy in the form of PD-1/PD-L1 with CTLA-4 blockade. The investigation of the current literature on immune checkpoint inhibition found that preclinical data show a decrease in tumor volumes and size when PD-1/PD-L1 is blocked, and similar results were observed with CTLA-4 blockade. However, there are limited investigations evaluating the combination of CTLA-4 and PD-1/PD-L1 blockade. We anticipate this review to provide a foundation for a deeper experimental investigation into combination immune checkpoint inhibition therapy in metastatic urothelial carcinoma.

Published
2023
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131. HER2 Alterations in Non-Small Cell Lung Cancer: Biologico-Clinical Consequences and Interest in Therapeutic Strategies

Author

Emma Loeffler, Julien Ancel, Véronique Dalstein, Gaëtan Deslée, Myriam Polette, and Béatrice Nawrocki-Raby

Subjects
non-small cell lung cancer, oncogenic drivers, HER2 alterations, anti-HER2 targeted therapy, Science
Abstract

Lung cancer stands as the first cause of death by cancer in the world. Despite the improvement in patients’ outcomes in the past decades through the development of personalized medicine approaches, a substantial portion of patients remains ineligible for targeted therapies due to the lack of a “druggable” molecular target. HER2, a receptor tyrosine kinase member of the EGFR/ErbB family, is known to show oncogenic properties. In this review, we focus on the different HER2 dysregulation mechanisms that have been observed in non-small cell lung cancer (NSCLC): gene mutation, gene amplification, protein overexpression and protein hyper-phosphorylation, the latter suggesting that HER2 dysregulation can occur independently of any molecular aberration. These HER2 alterations inevitably have consequences on tumor biology. Here, we discuss how they are not only involved in abnormal proliferation and survival of cancer cells but also potentially in increased angiogenic properties, mesenchymal features and tumor immune escape. Finally, we review the impact of these HER2 alterations in various therapeutic approaches. While standard chemotherapy and groundbreaking immunotherapy seem rather ineffective for HER2-altered NSCLCs, the development of HER2-targeted therapies such as tyrosine kinase inhibitors, anti-HER2 antibodies and especially antibody–drug conjugates could provide new hopes for patients.

Published
2023
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132. Morphological Evaluation of the Incisive Canal in the Aspect of the Diagnosis and Planning of Orthodontic Treatment—CBCT Study

Author

Anna Ewa Kuc, Jacek Kotuła, Jakub Nawrocki, Ewa Szeląg, Beata Kawala, Joanna Lis, and Michał Sarul

Subjects
anatomy, CBCT, root resorption, incisive canal, nasopalatine canal, retraction, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Background: Understanding the anatomy of the incisive canal is crucial for effective diagnosis and treatment planning in clinical orthodontics. This is because, during orthodontic tooth movement, there is a risk of contact between the roots of the upper central incisors and the incisive canal. Objective: The aim of this study was to assess the anatomical variability of the incisive canal using cone beam computed tomography (CBCT), as well as to evaluate its correlation with age, sex, and the position of the maxillary central incisors. There are only a few studies on this topic. Materials and methods: We analysed CBCT data from 67 patients aged from 13 to 49 years. This study was conducted at the Wroclaw Medical University. Measurements were performed twice by two independent researchers, and intra-observer error and correlation were calculated. The mean difference between the first and second observations and between observers was also assessed. We examined the dimensions of the incisive canal and its relationship to the roots of the upper central incisors in relation to age and gender. Results: Our study results revealed a significant correlation between the width and length of the incisive canal. Males exhibited a significantly greater canal length at the lowest point of the incisive canal on the palatal wall. Additionally, males had wider canals compared to females. The analysis of canal width and distance between the most mesial point of the root and the line passing through the most anterior point of the incisive canal showed a negative correlation in all age groups of men. The analysis of incisal inclination and incisal canal inclination showed a very strong relationship, especially in the age group of 13 to 20 years. Several potential risk groups of contact between the roots of central incisors and the incisive canal have been identified based on their structure and the planned incisors’ orthodontic movement. Conclusions and implications: Knowledge of the anatomy of the incisive canal and the use of 3D imaging in high-risk patients can prevent resorption of the incisor root by considering the individual anatomical conditions of the patient when planning orthodontic tooth movement. We recommend performing a CBCT scan before starting orthodontic treatment in the case of moderate and significant retraction of the incisors, or a significant change in their inclination due to the wide anatomical diversity of the incisive canal, especially in adult patients.

Published
2023
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133. Spin polarized semimagnetic exciton-polariton condensate in magnetic field

Author

Król, Mateusz, Mirek, Rafał, Lekenta, Katarzyna, Rousset, Jean-Guy, Stephan, Daniel, Nawrocki, Michał, Matuszewski, Michał, Szczytko, Jacek, Pacuski, Wojciech, and Piętka, Barbara

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Owing to their integer spin, exciton-polaritons in microcavities can be used for observation of non-equilibrium Bose-Einstein condensation in solid state. However, spin-related phenomena of such condensates are difficult to explore due to the relatively small Zeeman effect of standard semiconductor microcavity systems and the strong tendency to sustain an equal population of two spin components, which precludes the observation of condensates with a well defined spin projection along the axis of the system. The enhancement of the Zeeman splitting can be achieved by introducing magnetic ions to the quantum wells, and consequently forming semimagnetic polaritons. In this system, increasing magnetic field can induce polariton condensation at constant excitation power. Here we evidence the spin polarization of a semimagnetic polaritons condensate exhibiting a circularly polarized emission over 95% even in a moderate magnetic field of about 3 T. Furthermore, we show that unlike nonmagnetic polaritons, an increase on excitation power results in an increase of the semimagnetic polaritons condensate spin polarization. These properties open new possibilities for testing theoretically predicted phenomena of spin polarized condensate., Comment: 9 pages, 5 figures

Published
2018
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138. Bayard Rustin

Author

Nawrocki, Jim

Subjects
Literature/writing, Women's issues/gender studies
Abstract

DESPITE his admirably active life--more than four decades of protesting, writing, and speaking in support of a wide array of civil rights causes--Bayard Rustin, who died in 1987 at the [...]

Published
2024

139. RNAcentral: a hub of information for non-coding RNA sequences

Author

Sweeney, Blake A, Petrov, Anton I, Burkov, Boris, Finn, Robert D, Bateman, Alex, Szymanski, Maciej, Karlowski, Wojciech M, Gorodkin, Jan, Seemann, Stefan E, Cannone, Jamie J, Gutell, Robin R, Fey, Petra, Basu, Siddhartha, Kay, Simon, Cochrane, Guy, Billis, Kostantinos, Emmert, David, Marygold, Steven J, Huntley, Rachael P, Lovering, Ruth C, Frankish, Adam, Chan, Patricia P, Lowe, Todd M, Bruford, Elspeth, Seal, Ruth, Vandesompele, Jo, Volders, Pieter-Jan, Paraskevopoulou, Maria, Ma, Lina, Zhang, Zhang, Griffiths-Jones, Sam, Bujnicki, Janusz M, Boccaletto, Pietro, Blake, Judith A, Bult, Carol J, Chen, Runsheng, Zhao, Yi, Wood, Valerie, Rutherford, Kim, Rivas, Elena, Cole, James, Laulederkind, Stanley JF, Shimoyama, Mary, Gillespie, Marc E, Orlic-Milacic, Marija, Kalvari, Ioanna, Nawrocki, Eric, Engel, Stacia R, Cherry, J Michael, Team, SILVA, Berardini, Tanya Z, Hatzigeorgiou, Artemis, Karagkouni, Dimitra, Howe, Kevin, Davis, Paul, Dinger, Marcel, He, Shunmin, Yoshihama, Maki, Kenmochi, Naoya, Stadler, Peter F, and Williams, Kelly P

Subjects
Biological Sciences, Environmental Sciences, Chemical Sciences, The RNAcentral Consortium, Information and Computing Sciences, Developmental Biology, Biological sciences, Chemical sciences, Environmental sciences
Published
2019

140. Erratum to: Measurement of the top quark mass with lepton+jets final states using pp collisions at $$\sqrt{s} = 13\,\hbox {TeV}$$ s = 13 TeV

Author

A. M. Sirunyan, A. Tumasyan, W. Adam, F. Ambrogi, E. Asilar, T. Bergauer, J. Brandstetter, E. Brondolin, M. Dragicevic, J. Erö, A. Escalante Del Valle, M. Flechl, M. Friedl, R. Frühwirth, V. M. Ghete, J. Hrubec, M. Jeitler, N. Krammer, I. Krätschmer, D. Liko, T. Madlener, I. Mikulec, N. Rad, H. Rohringer, J. Schieck, R. Schöfbeck, M. Spanring, D. Spitzbart, A. Taurok, W. Waltenberger, J. Wittmann, C.-E. Wulz, M. Zarucki, V. Chekhovsky, V. Mossolov, J. Suarez Gonzalez, E. A. De Wolf, D. Di Croce, X. Janssen, J. Lauwers, M. Pieters, M. Van De Klundert, H. Van Haevermaet, P. Van Mechelen, N. Van Remortel, S. Abu Zeid, F. Blekman, J. D’Hondt, I. De Bruyn, J. De Clercq, K. Deroover, G. Flouris, D. Lontkovskyi, S. Lowette, I. Marchesini, S. Moortgat, L. Moreels, Q. Python, K. Skovpen, S. Tavernier, W. Van Doninck, P. Van Mulders, I. Van Parijs, D. Beghin, B. Bilin, H. Brun, B. Clerbaux, G. De Lentdecker, H. Delannoy, B. Dorney, G. Fasanella, L. Favart, R. Goldouzian, A. Grebenyuk, A. K. Kalsi, T. Lenzi, J. Luetic, T. Seva, E. Starling, C. Vander Velde, P. Vanlaer, D. Vannerom, R. Yonamine, T. Cornelis, D. Dobur, A. Fagot, M. Gul, I. Khvastunov, D. Poyraz, C. Roskas, D. Trocino, M. Tytgat, W. Verbeke, B. Vermassen, M. Vit, N. Zaganidis, H. Bakhshiansohi, O. Bondu, S. Brochet, G. Bruno, C. Caputo, A. Caudron, P. David, S. De Visscher, C. Delaere, M. Delcourt, B. Francois, A. Giammanco, G. Krintiras, V. Lemaitre, A. Magitteri, A. Mertens, M. Musich, K. Piotrzkowski, L. Quertenmont, A. Saggio, M. Vidal Marono, S. Wertz, J. Zobec, W. L. Aldá Júnior, F. L. Alves, G. A. Alves, L. Brito, G. Correia Silva, C. Hensel, A. Moraes, M. E. Pol, P. Rebello Teles, E. Belchior Batista Das Chagas, W. Carvalho, J. Chinellato, E. Coelho, E. M. Da Costa, G. G. Da Silveira, D. De Jesus Damiao, S. Fonseca De Souza, H. Malbouisson, M. Medina Jaime, M. Melo De Almeida, C. Mora Herrera, L. Mundim, H. Nogima, L. J. Sanchez Rosas, A. Santoro, A. Sznajder, M. Thiel, E. J. Tonelli Manganote, F. Torres Da Silva De Araujo, A. Vilela Pereira, S. Ahuja, C. A. Bernardes, Luigi Calligaris, T. R. Fernandez Perez Tomei, E. M. Gregores, P. G. Mercadante, S. F. Novaes, Sandra S. Padula, D. Romero Abad, J. C. Ruiz Vargas, A. Aleksandrov, R. Hadjiiska, P. Iaydjiev, A. Marinov, M. Misheva, M. Rodozov, M. Shopova, G. Sultanov, A. Dimitrov, L. Litov, B. Pavlov, P. Petkov, W. Fang, X. Gao, L. Yuan, M. Ahmad, J. G. Bian, G. M. Chen, H. S. Chen, M. Chen, Y. Chen, C. H. Jiang, D. Leggat, H. Liao, Z. Liu, F. Romeo, S. M. Shaheen, A. Spiezia, J. Tao, C. Wang, Z. Wang, E. Yazgan, H. Zhang, J. Zhao, Y. Ban, G. Chen, J. Li, Q. Li, S. Liu, Y. Mao, S. J. Qian, D. Wang, Z. Xu, Y. Wang, C. Avila, A. Cabrera, C. A. Carrillo Montoya, L. F. Chaparro Sierra, C. Florez, C. F. González Hernández, M. A. Segura Delgado, B. Courbon, N. Godinovic, D. Lelas, I. Puljak, T. Sculac, Z. Antunovic, M. Kovac, V. Brigljevic, D. Ferencek, K. Kadija, B. Mesic, A. Starodumov, T. Susa, M. W. Ather, A. Attikis, G. Mavromanolakis, J. Mousa, C. Nicolaou, F. Ptochos, P. A. Razis, H. Rykaczewski, M. Finger, E. Carrera Jarrin, M. A. Mahmoud, Elgammal A. Mohamed, E. Salama, S. Bhowmik, R. K. Dewanjee, M. Kadastik, L. Perrini, M. Raidal, C. Veelken, P. Eerola, H. Kirschenmann, J. Pekkanen, M. Voutilainen, J. Havukainen, J. K. Heikkilä, T. Järvinen, V. Karimäki, R. Kinnunen, T. Lampén, K. Lassila-Perini, S. Laurila, S. Lehti, T. Lindén, P. Luukka, T. Mäenpää, H. Siikonen, E. Tuominen, J. Tuominiemi, T. Tuuva, M. Besancon, F. Couderc, M. Dejardin, D. Denegri, J. L. Faure, F. Ferri, S. Ganjour, S. Ghosh, A. Givernaud, P. Gras, G. Hamel de Monchenault, P. Jarry, C. Leloup, E. Locci, M. Machet, J. Malcles, G. Negro, J. Rander, A. Rosowsky, M.Ö. Sahin, M. Titov, A. Abdulsalam, C. Amendola, I. Antropov, S. Baffioni, F. Beaudette, P. Busson, L. Cadamuro, C. Charlot, R. Granier de Cassagnac, M. Jo, I. Kucher, S. Lisniak, A. Lobanov, J. Martin Blanco, M. Nguyen, C. Ochando, G. Ortona, P. Paganini, P. Pigard, R. Salerno, J. B. Sauvan, Y. Sirois, A. G. Stahl Leiton, Y. Yilmaz, A. Zabi, A. Zghiche, J.-L. Agram, J. Andrea, D. Bloch, J.-M. Brom, E. C. Chabert, C. Collard, E. Conte, X. Coubez, F. Drouhin, J.-C. Fontaine, D. Gelé, U. Goerlach, M. Jansová, P. Juillot, A.-C. Le Bihan, N. Tonon, P. Van Hove, S. Gadrat, S. Beauceron, C. Bernet, G. Boudoul, N. Chanon, R. Chierici, D. Contardo, P. Depasse, H. El Mamouni, J. Fay, L. Finco, S. Gascon, M. Gouzevitch, G. Grenier, B. Ille, F. Lagarde, I. B. Laktineh, H. Lattaud, M. Lethuillier, L. Mirabito, A. L. Pequegnot, S. Perries, A. Popov, V. Sordini, M. Vander Donckt, S. Viret, S. Zhang, T. Toriashvili, Z. Tsamalaidze, C. Autermann, L. Feld, M. K. Kiesel, K. Klein, M. Lipinski, M. Preuten, M. P. Rauch, C. Schomakers, J. Schulz, M. Teroerde, B. Wittmer, V. Zhukov, A. Albert, D. Duchardt, M. Endres, M. Erdmann, S. Erdweg, T. Esch, R. Fischer, A. Güth, T. Hebbeker, C. Heidemann, K. Hoepfner, S. Knutzen, M. Merschmeyer, A. Meyer, P. Millet, S. Mukherjee, T. Pook, M. Radziej, H. Reithler, M. Rieger, F. Scheuch, D. Teyssier, S. Thüer, G. Flügge, B. Kargoll, T. Kress, A. Künsken, T. Müller, A. Nehrkorn, A. Nowack, C. Pistone, O. Pooth, A. Stahl, M. Aldaya Martin, T. Arndt, C. Asawatangtrakuldee, I. Babounikau, K. Beernaert, O. Behnke, U. Behrens, A. Bermúdez Martínez, D. Bertsche, A. A. Bin Anuar, K. Borras, V. Botta, A. Campbell, P. Connor, C. Contreras-Campana, F. Costanza, V. Danilov, A. De Wit, C. Diez Pardos, D. Domínguez Damiani, G. Eckerlin, D. Eckstein, T. Eichhorn, A. Elwood, E. Eren, E. Gallo, J. Garay Garcia, A. Geiser, J. M. Grados Luyando, A. Grohsjean, P. Gunnellini, M. Guthoff, A. Harb, J. Hauk, H. Jung, M. Kasemann, J. Keaveney, C. Kleinwort, J. Knolle, I. Korol, D. Krücker, W. Lange, A. Lelek, T. Lenz, K. Lipka, W. Lohmann, R. Mankel, I.-A. Melzer-Pellmann, A. B. Meyer, M. Meyer, M. Missiroli, G. Mittag, J. Mnich, A. Mussgiller, S. K. Pflitsch, D. Pitzl, A. Raspereza, M. Savitskyi, P. Saxena, C. Schwanenberger, R. Shevchenko, A. Singh, N. Stefaniuk, H. Tholen, G. P. Van Onsem, R. Walsh, Y. Wen, K. Wichmann, C. Wissing, O. Zenaiev, R. Aggleton, S. Bein, V. Blobel, M. Centis Vignali, T. Dreyer, C. Garbers, E. Garutti, D. Gonzalez, J. Haller, A. Hinzmann, M. Hoffmann, A. Karavdina, G. Kasieczka, R. Klanner, R. Kogler, N. Kovalchuk, S. Kurz, V. Kutzner, J. Lange, D. Marconi, J. Multhaup, M. Niedziela, D. Nowatschin, T. Peiffer, A. Perieanu, A. Reimers, C. Scharf, P. Schleper, A. Schmidt, S. Schumann, J. Schwandt, J. Sonneveld, H. Stadie, G. Steinbrück, F. M. Stober, M. Stöver, D. Troendle, E. Usai, A. Vanhoefer, B. Vormwald, M. Akbiyik, C. Barth, M. Baselga, S. Baur, E. Butz, R. Caspart, T. Chwalek, F. Colombo, W. De Boer, A. Dierlamm, N. Faltermann, B. Freund, R. Friese, M. Giffels, M. A. Harrendorf, F. Hartmann, S. M. Heindl, U. Husemann, F. Kassel, S. Kudella, H. Mildner, M. U. Mozer, Th. Müller, M. Plagge, G. Quast, K. Rabbertz, M. Schröder, I. Shvetsov, G. Sieber, H. J. Simonis, R. Ulrich, S. Wayand, M. Weber, T. Weiler, S. Williamson, C. Wöhrmann, R. Wolf, G. Anagnostou, G. Daskalakis, T. Geralis, A. Kyriakis, D. Loukas, I. Topsis-Giotis, G. Karathanasis, S. Kesisoglou, A. Panagiotou, N. Saoulidou, E. Tziaferi, K. Kousouris, I. Papakrivopoulos, I. Evangelou, C. Foudas, P. Gianneios, P. Katsoulis, P. Kokkas, S. Mallios, N. Manthos, I. Papadopoulos, E. Paradas, J. Strologas, F. A. Triantis, D. Tsitsonis, M. Csanad, N. Filipovic, G. Pasztor, O. Surányi, G. I. Veres, G. Bencze, C. Hajdu, D. Horvath, Á. Hunyadi, F. Sikler, T.Á. Vámi, V. Veszpremi, G. Vesztergombi, N. Beni, S. Czellar, J. Karancsi, A. Makovec, J. Molnar, Z. Szillasi, M. Bartók, P. Raics, Z. L. Trocsanyi, B. Ujvari, S. Choudhury, J. R. Komaragiri, S. Bahinipati, P. Mal, K. Mandal, A. Nayak, D. K. Sahoo, S. K. Swain, S. Bansal, S. B. Beri, V. Bhatnagar, S. Chauhan, R. Chawla, N. Dhingra, R. Gupta, A. Kaur, M. Kaur, S. Kaur, R. Kumar, P. Kumari, M. Lohan, A. Mehta, S. Sharma, J. B. Singh, G. Walia, A. Bhardwaj, B. C. Choudhary, R. B. Garg, S. Keshri, A. Kumar, Ashok Kumar, S. Malhotra, M. Naimuddin, K. Ranjan, Aashaq Shah, R. Sharma, R. Bhardwaj, R. Bhattacharya, S. Bhattacharya, U. Bhawandeep, D. Bhowmik, S. Dey, S. Dutt, S. Dutta, N. Majumdar, K. Mondal, S. Mukhopadhyay, S. Nandan, A. Purohit, P. K. Rout, A. Roy, S. Roy Chowdhury, S. Sarkar, M. Sharan, B. Singh, S. Thakur, P. K. Behera, R. Chudasama, D. Dutta, V. Jha, V. Kumar, A. K. Mohanty, P. K. Netrakanti, L. M. Pant, P. Shukla, A. Topkar, T. Aziz, S. Dugad, B. Mahakud, S. Mitra, G. B. Mohanty, N. Sur, B. Sutar, S. Banerjee, S. Chatterjee, P. Das, M. Guchait, Sa. Jain, S. Kumar, M. Maity, G. Majumder, K. Mazumdar, N. Sahoo, T. Sarkar, N. Wickramage, S. Dube, V. Hegde, A. Kapoor, K. Kothekar, S. Pandey, A. Rane, S. Chenarani, E. Eskandari Tadavani, S. M. Etesami, M. Khakzad, M. Mohammadi Najafabadi, M. Naseri, S. Paktinat Mehdiabadi, F. Rezaei Hosseinabadi, B. Safarzadeh, M. Zeinali, M. Felcini, M. Grunewald, M. Abbrescia, C. Calabria, A. Colaleo, D. Creanza, L. Cristella, N. De Filippis, M. De Palma, A. Di Florio, F. Errico, L. Fiore, A. Gelmi, G. Iaselli, S. Lezki, G. Maggi, M. Maggi, B. Marangelli, G. Miniello, S. My, S. Nuzzo, A. Pompili, G. Pugliese, R. Radogna, A. Ranieri, G. Selvaggi, A. Sharma, L. Silvestris, R. Venditti, P. Verwilligen, G. Zito, G. Abbiendi, C. Battilana, D. Bonacorsi, L. Borgonovi, S. Braibant-Giacomelli, L. Brigliadori, R. Campanini, P. Capiluppi, A. Castro, F. R. Cavallo, S. S. Chhibra, G. Codispoti, M. Cuffiani, G. M. Dallavalle, F. Fabbri, A. Fanfani, D. Fasanella, P. Giacomelli, C. Grandi, L. Guiducci, F. Iemmi, S. Marcellini, G. Masetti, A. Montanari, F. L. Navarria, A. Perrotta, T. Rovelli, G. P. Siroli, N. Tosi, S. Albergo, S. Costa, A. Di Mattia, F. Giordano, R. Potenza, A. Tricomi, C. Tuve, G. Barbagli, K. Chatterjee, V. Ciulli, C. Civinini, R. D’Alessandro, E. Focardi, G. Latino, P. Lenzi, M. Meschini, S. Paoletti, L. Russo, G. Sguazzoni, D. Strom, L. 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Jeng, R. G. Kellogg, J. Kunkle, A. C. Mignerey, F. Ricci-Tam, Y. H. Shin, A. Skuja, S. C. Tonwar, D. Abercrombie, B. Allen, V. Azzolini, R. Barbieri, A. Baty, G. Bauer, R. Bi, S. Brandt, W. Busza, I. A. Cali, M. D’Alfonso, Z. Demiragli, G. Gomez Ceballos, M. Goncharov, P. Harris, D. Hsu, M. Hu, Y. Iiyama, G. M. Innocenti, M. Klute, D. Kovalskyi, Y.-J. Lee, A. Levin, P. D. Luckey, B. Maier, A. C. Marini, C. Mcginn, C. Mironov, S. Narayanan, X. Niu, C. Paus, C. Roland, G. Roland, G. S. F. Stephans, K. Sumorok, K. Tatar, D. Velicanu, T. W. Wang, B. Wyslouch, S. Zhaozhong, A. C. Benvenuti, R. M. Chatterjee, A. Evans, P. Hansen, S. Kalafut, Y. Kubota, Z. Lesko, J. Mans, S. Nourbakhsh, N. Ruckstuhl, R. Rusack, J. Turkewitz, M. A. Wadud, J. G. Acosta, S. Oliveros, E. Avdeeva, K. Bloom, D. R. Claes, C. Fangmeier, F. Golf, R. Gonzalez Suarez, R. Kamalieddin, I. Kravchenko, J. Monroy, J. E. Siado, G. R. Snow, B. Stieger, A. Godshalk, C. Harrington, I. Iashvili, D. Nguyen, A. Parker, S. Rappoccio, B. Roozbahani, G. Alverson, E. Barberis, C. Freer, A. Hortiangtham, A. Massironi, D. M. Morse, T. Orimoto, R. Teixeira De Lima, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, O. Charaf, K. A. Hahn, N. Mucia, N. Odell, M. H. Schmitt, K. Sung, M. Trovato, M. Velasco, R. Bucci, N. Dev, M. Hildreth, K. Hurtado Anampa, C. Jessop, D. J. Karmgard, N. Kellams, K. Lannon, W. Li, N. Loukas, N. Marinelli, F. Meng, C. Mueller, Y. Musienko, M. Planer, A. Reinsvold, R. Ruchti, P. Siddireddy, G. Smith, S. Taroni, M. Wayne, A. Wightman, M. Wolf, A. Woodard, J. Alimena, L. Antonelli, B. Bylsma, L. S. Durkin, S. Flowers, B. Francis, A. Hart, C. Hill, W. Ji, T. Y. Ling, W. Luo, B. L. Winer, H. W. Wulsin, S. Cooperstein, O. Driga, P. Elmer, J. Hardenbrook, P. Hebda, S. Higginbotham, A. Kalogeropoulos, D. Lange, J. Luo, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, C. Palmer, P. Piroué, J. Salfeld-Nebgen, D. Stickland, C. Tully, S. Norberg, A. Barker, V. E. Barnes, S. Das, L. Gutay, M. Jones, A. W. Jung, A. Khatiwada, D. H. Miller, N. Neumeister, C. C. Peng, H. Qiu, J. F. Schulte, J. Sun, F. Wang, R. Xiao, W. Xie, T. Cheng, J. Dolen, N. Parashar, Z. Chen, K. M. Ecklund, S. Freed, F. J. M. Geurts, M. Guilbaud, M. Kilpatrick, B. Michlin, B. P. Padley, J. Roberts, J. Rorie, W. Shi, Z. Tu, J. Zabel, A. Zhang, A. Bodek, P. de Barbaro, R. Demina, Y. t. Duh, T. Ferbel, M. Galanti, A. Garcia-Bellido, J. Han, O. Hindrichs, A. Khukhunaishvili, K. H. Lo, P. Tan, M. Verzetti, R. Ciesielski, K. Goulianos, C. Mesropian, A. Agapitos, J. P. Chou, Y. Gershtein, T. A. Gómez Espinosa, E. Halkiadakis, M. Heindl, E. Hughes, S. Kaplan, R. Kunnawalkam Elayavalli, S. Kyriacou, A. Lath, R. Montalvo, K. Nash, M. Osherson, H. Saka, S. Salur, S. Schnetzer, D. Sheffield, S. Somalwar, R. Stone, S. Thomas, P. Thomassen, M. Walker, A. G. Delannoy, J. Heideman, G. Riley, K. Rose, S. Spanier, K. Thapa, O. Bouhali, A. Castaneda Hernandez, A. Celik, M. Dalchenko, M. De Mattia, A. Delgado, S. Dildick, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, R. Mueller, Y. Pakhotin, R. Patel, A. Perloff, L. Perniè, D. Rathjens, A. Safonov, A. Tatarinov, N. Akchurin, J. Damgov, F. De Guio, P. R. Dudero, J. Faulkner, E. Gurpinar, S. Kunori, K. Lamichhane, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, J. D. Ruiz Alvarez, P. Sheldon, S. Tuo, J. Velkovska, Q. Xu, M. W. Arenton, P. Barria, B. Cox, R. Hirosky, M. Joyce, A. Ledovskoy, H. Li, C. Neu, T. Sinthuprasith, E. Wolfe, F. Xia, R. Harr, P. E. Karchin, N. Poudyal, J. Sturdy, P. Thapa, S. Zaleski, M. Brodski, J. Buchanan, C. Caillol, D. Carlsmith, S. Dasu, L. Dodd, S. Duric, B. Gomber, M. Grothe, M. Herndon, A. Hervé, U. Hussain, P. Klabbers, A. Lanaro, A. Levine, K. Long, R. Loveless, V. Rekovic, T. Ruggles, A. Savin, N. Smith, W. H. Smith, N. Woods, and CMS Collaboration

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Published
2022
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141. Targeted CUL4A inhibition synergizes with cisplatin to yield long-term survival in models of head and neck squamous cell carcinoma through a DDB2-mediated mechanism

Author

Trace M. Jones, Claudia M. Espitia, Aikseng Ooi, Julie E. Bauman, Jennifer S. Carew, and Steffan T. Nawrocki

Subjects
Cytology, QH573-671
Abstract

Abstract Patients with late-stage and human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) continue to have a very poor prognosis. The development of more effective novel therapies that improve overall survival and overcome drug resistance is an urgent priority. Here we report that HNSCC tumors significantly overexpress NEDD8 and exhibit high sensitivity to the first-in-class NEDD8-activating enzyme (NAE) inhibitor pevonedistat. Additional studies established that disruption of NEDD8-mediated protein turnover with pevonedistat dramatically augmented cisplatin-induced DNA damage and apoptosis in HNSCC models. Further analysis revealed that the specific pevonedistat target CUL4A played an essential role in driving the synergy of the pevonedistat and cisplatin combination. Targeted inhibition of CUL4A resulted in significant downregulation in Damage Specific DNA binding protein 2 (DDB2), a DNA-damage recognition protein that promotes nucleotide excision repair and resistance to cisplatin. Silencing of CUL4A or DDB2 enhanced cisplatin-induced DNA damage and apoptosis in a manner similar to that of pevonedistat demonstrating that targeted inhibition of CUL4A may be a novel approach to augment cisplatin therapy. Administration of pevonedistat to mice bearing HNSCC tumors significantly decreased DDB2 expression in tumor cells, increased DNA damage and potently enhanced the activity of cisplatin to yield tumor regression and long-term survival of all animals. Our findings provide strong rationale for clinical investigation of CUL4A inhibition with pevonedistat as a novel strategy to augment the efficacy of cisplatin therapy for patients with HNSCC and identify loss of DDB2 as a key pharmacodynamic mediator controlling sensitivity to this regimen.

Published
2022
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147. Innovativeness in energy companies in developing economies: Determinants, evaluation and comparative analysis using the example of Poland

Author

Tomasz L. Nawrocki and Izabela Jonek-Kowalska

Subjects
Potential and resultant innovativeness, Evaluation of innovativeness in energy companies, Energy in developing economies, Management. Industrial management, HD28-70, Business, HF5001-6182
Abstract

Energy and the energy transition associated with its operation requires the creation and implementation of innovations, without which effective changes in the energy balance and greenhouse gas emissions will not be possible. This is particularly important in emerging and developing economies, which are often unable to meet modern environmental requirements. Various approaches to assessing innovation are proposed in research and literature. Nevertheless, there is a lack of holistic methods (assessing both the potential and the results of innovation), based on publicly available data and taking into account the specificity of the sector. Therefore, the objective of this article is to develop a model for evaluating innovativeness (potential and resultant) of companies in the energy sector. Additional sub-goals are: (a) using the developed model to evaluate innovativeness of seven Polish energy companies; (b) conducting a comparative analysis in terms of resultant and potential innovation for seven Polish energy companies and (c) specifying recommendations for improving the innovativeness of the examined companies and the Polish energy sector operating in a developing economy. The proposed model is based on publicly available financial data and takes into account two areas: 1. Potential innovativeness, allowing to determine the scale and type of resources supporting the creation of innovation; and 2. Resultant innovativeness, including the actual effects of pro-innovation activities. The evaluation of innovativeness in the above dimensions was carried out in 2016–2021 for seven key energy companies listed on the Warsaw Stock Exchange and operating in the Polish energy market. The study found that the best innovativeness performance was achieved by multinationals and companies with a high share of renewable sources in installed capacity and in production. In addition, the identified low degree of involvement of state-owned companies in the energy transition is not conducive to improving innovativeness and strengthening innovativeness at the national level.

Published
2023
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148. TNFα aggravates detrimental effects of SARS-CoV-2 infection in the liver

Author

Jöran Lücke, Mikolaj Nawrocki, Josa Schnell, Nicholas Meins, Fabian Heinrich, Tao Zhang, Franziska Bertram, Morsal Sabihi, Marius Böttcher, Tom Blankenburg, Marie Pfaff, Sara Notz, Jan Kempski, Matthias Reeh, Stefan Wolter, Oliver Mann, Jakob R. Izbicki, Marc Lütgehetmann, Anna Duprée, Anastasios D. Giannou, Benjamin Ondruschka, and Samuel Huber

Subjects
SARS-CoV-2, liver, TNFa, post-mortem, Cxcl3, Cxcl8, Immunologic diseases. Allergy, RC581-607
Abstract

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus does not only lead to pulmonary infection but can also infect other organs such as the gut, the kidney, or the liver. Recent studies confirmed that severe cases of COVID-19 are often associated with liver damage and liver failure, as well as the systemic upregulation of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFα). However, the impact these immune mediators in the liver have on patient survival during SARS-CoV-2 infection is currently unknown. Here, by performing a post-mortem analysis of 45 patients that died from a SARS-CoV-2 infection, we find that an increased expression of TNFA in the liver is associated with elevated mortality. Using publicly available single-cell sequencing datasets, we determined that Kupffer cells and monocytes are the main sources of this TNFα production. Further analysis revealed that TNFα signaling led to the upregulation of pro-inflammatory genes that are associated with an unfavorable outcome. Moreover, high levels of TNFA in the liver were associated with lower levels of interferon alpha and interferon beta. Thus, TNFα signaling in the infected SARS-CoV-2 liver correlates with reduced interferon levels and overall survival time.

Published
2023
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149. Perspectives on dental health and oral hygiene practice from US adolescents and young adults during the COVID-19 pandemic

Author

Long Zhang, Marika Waselewski, Jack Nawrocki, Ian Williams, Margherita Fontana, and Tammy Chang

Subjects
Medicine, Science
Abstract

Background Adolescence is a critical time for adopting health behaviors which continue through adulthood. There is a lack of data regarding perspectives of US adolescents and young adults on their dental health and oral hygiene practice. Methods Adolescents and young adults, age 14–24, from MyVoice, a nationwide text message poll of youth. were asked five open-ended questions on the importance of dental health and impact of the COVID-19 pandemic. Responses were qualitatively analyzed using thematic analysis. Chi-square test was used to examine differences in experiences by demographics. Results Of 1,148 participants, 932 responded to at least one question. The mean age was 19 years. Respondents were largely male (49.5%) and non-Hispanic white (62.4%). Most (92%) respondents perceived dental health as important or somewhat important and emphasized overall dental health and hygiene (38.6%) and aesthetics (18.3%). About half (49.2%) of respondents stated they have had at least one cavity since middle school. Just over half (54.8%) reported brushing and flossing to care for their dentition. 58% visited a dentist at least every 6 months, while 38% visited a dentist less frequently or not at all. Being non-cisgender, non-Hispanic black, Hispanic, and receipt of free or reduced lunch was associated with less frequent dental visits. 44% stated COVID-19 impacted their dental health, with many mentioning scheduling difficulties or worsened dental hygiene. Conclusions Most youth in our study consider dental health important, though their oral hygiene practice may not follow ADA guidelines and self-reported dental caries are high. Dental healthcare among youth has been affected by the COVID-19 pandemic with interruption in regular dental visits and changes in hygiene habits. Re-engagement of adolescents and young adults by dental care providers via greater access to appointments and youth-centered messaging reinforcing hygiene recommendations may help youth improve dental health now and in the future.

Published
2023

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