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442 results on '"Nakajima, Hiroaki"'

115. Environmental conditions for seed germination and seedling growth of Cinnamomum camphora(Lauraceae): the possibility of regeneration in an abandoned deciduous broad-leaved forest, eastern Japan

Author

Kameyama, Yoshiaki and Nakajima, Hiroaki

Abstract

ABSTRACTCinnamomum camphorais an evergreen broad-leaved tree distributed throughout southeastern China, Taiwan, and southern Japan. This tree has been widely cultivated and utilized by humans since ancient times; therefore, its natural distribution and regeneration are ambiguous. We established a mowing zone and a control zone in an abandoned deciduous broad-leaved forest in eastern Japan. In the mowing zone, an evergreen dwarf bamboo, Pleioblastus chino, and evergreen broad-leaved trees such as Quercus myrsinifoliaand Eurya japonicawere cut at ground level. We set nine study sites (1 × 1 m quadrats) on the forest floor of these zones, and measured the fraction of absorbed photosynthetically active radiation (fAPAR), soil moisture content, and soil temperature. Overall, 120 seeds of C. camphorawere sown at a depth of 1 cm on each site, and seed germination and the survival and growth of seedlings were monitored over 4 years. Seed germination ratios at the sites were negatively affected by fAPAR and soil moisture content and positively affected by daily fluctuation of soil temperature. Seedling survival ratios and heights were negatively affected by fAPAR and positively affected by soil moisture content; no seedlings survived at the control site, and the height of seedlings was significantly higher under the canopy gap. Seeds of C. camphoracould germinate in an abandoned secondary forest in eastern Japan, but the dominance of P. chinolargely prevented the establishment of seedlings; the presence of a canopy gap, along with consecutive mowing, was considered to be indispensable for regeneration.

Published
2018
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116. 上演芸術の経験を分析するための方法 : 花家彩子によるオートエスノグラフィー

Author

中島,裕昭, 花家,彩子, ナカジマ,ヒロアキ, ハナケ,アヤコ, NAKAJIMA,Hiroaki, HANAKE,Ayako, 中島,裕昭(東京学芸大学音楽・演劇講座演劇分野), 花家,彩子(東京学芸大学大学院連合学校教育学研究科), 中島,裕昭, 花家,彩子, ナカジマ,ヒロアキ, ハナケ,アヤコ, NAKAJIMA,Hiroaki, HANAKE,Ayako, 中島,裕昭(東京学芸大学音楽・演劇講座演劇分野), and 花家,彩子(東京学芸大学大学院連合学校教育学研究科)

Published
2012

117. Tiotropium bromide inhibits TGF-ß-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro

Author

Asano,Kazuhito, Shikama,Yusuke, Shoji,Naruo, Hirano,Kojiro, Suzaki,Harumi, Nakajima,Hiroaki, Asano,Kazuhito, Shikama,Yusuke, Shoji,Naruo, Hirano,Kojiro, Suzaki,Harumi, and Nakajima,Hiroaki

Abstract

Kazuhito Asano1, Yusuke Shikama2, Naruo Shoji3, Kojiro Hirano3, Harumi Suzaki3, Hiroaki Nakajima21Division of Physiology, School of Nursing and Rehabilitation Sciences, Showa University, Yokohama, Japan; 2Department of Respiratory Diseases, Showa University Northern Yokohamashi Hospital, Yokohama, Japan; 3Department of Otorhinolaryngology, School of Medicine, Showa University, Tokyo, JapanBackground: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and structural alterations (ie, tissue remodeling) throughout the conducting airways, parenchyma, and pulmonary vasculature. Matrix metalloproteinases (MMPs) are extracellular degrading enzymes that play a critical role in inflammatory cell infiltration and tissue ­remodeling, but the influence of the agents that are used for the treatment of COPD on the production of MMPs is not well understood.Purpose: The present study aimed to examine the influence of tiotropium bromide hydrate (TBH) on the production of MMPs from lung fibroblasts (LFs) induced by transforming growth factor (TGF)-ß in vitro.Methods: LFs, at a concentration of 5 × 105 cells·mL-1, were stimulated with TGF-ß in the presence of various concentrations of TBH. MMP-1 and MMP-2 levels in culture ­supernatants were examined by enzyme-linked immunosorbent assay (ELISA), and MMP messenger ribonucleic acid (mRNA) expression was examined by real-time polymerase chain reaction (RT-PCR). The influence of TBH on TGF-ß signaling pathways was also analyzed by ­examining Smad activation and signaling protein phosphorylation by ELISA.Results: TBH at more than 15 pg·mL-1 inhibited the production of MMP-1 and MMP-2, but not tissue inhibitor of matrix metalloproteinase (TIMP)-1 and TIMP-2, from LFs, after TGF-ß stimulation. TBH also suppressed MMP mRNA expression through the inhibition of Smad activation and signaling protein, extracellular-si

Published
2010

118. Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro

Author

Asano,Kazuhito, Shikama,Yusuke, Shibuya,Yasuhiro, Nakajima,Hiroaki, Kanai,Ken-ichi, Yamada,Naohiro, Suzaki,Harumi, Asano,Kazuhito, Shikama,Yusuke, Shibuya,Yasuhiro, Nakajima,Hiroaki, Kanai,Ken-ichi, Yamada,Naohiro, and Suzaki,Harumi

Abstract

Kazuhito Asano1, Yusuke Shikama2, Yasuhiro Shibuya2, Hiroaki Nakajima2, Ken-ichi Kanai3, Naohiro Yamada3, Harumi Suzaki31Division of Physiology, School of Nursing and Rehabilitation Sciences; 2Respiratory Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan; 3Department of Otolaryngology, School of Medicine, Showa University, Tokyo, JapanBackground: Chronic obstructive pulmonary disease (COPD) is characterized by airway remodeling with an accumulation of inflammatory cells. There is also increasing evidence that metalloproteinases (MMPs) may contribute to the pathogenesis of COPD, but the influence of agents that used for the treatment of COPD is not well understood.Objective: We evaluated whether tiotropium bromide hydrate (TBH), a M3 muscarinic receptor antagonist, could inhibit MMP production from lung fibroblasts (LFs) in response to tumor necrosis factor (TNF)-α stimulation.Methods: LFs were established from normal lung tissues taken from patients with lung tumors. LFs (5 × 105 cells/ml) were stimulated with TNF-α in the presence of various concentrations of TBH. After 24 h, culture supernatants were obtained and assayed for the levels of MMPs and tissue inhibitor of metalloproteinases (TIMPs) by ELISA. The influence of TBH on mRNA expression of MMPs and TIMPs in 4 h-cultured cells was also examined by real-time RT-PCR. Furthermore, nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) in LFs treated with TBH for 4 h was examined by ELISA.Results: TBH at more than 15 pg/ml inhibited the production of MMP-2 from LFs after TNF-α stimulation, whereas TIMP-1 and TIMP-2 production was scarcely affected by TBH through the suppression of both mRNA expression and transcription factor, NF-κB, activation in LFs induced by TNF-α stimulation.Conclusion: These results suggest that the attenuating effect of TBH on MMP-2 production from LFs induced by inflammatory stimul

Published
2008

137. Glycomics of a novel type-2 N-acetyllactosamine-specific lectin purified from the feather star, Oxycomanthus japonicus (Pelmatozoa: Crinoidea)

Author

Matsumoto, Ryo, primary, Shibata, Tomoko F., additional, Kohtsuka, Hisanori, additional, Sekifuji, Mamoru, additional, Sugii, Natsuko, additional, Nakajima, Hiroaki, additional, Kojima, Noriaki, additional, Fujii, Yuki, additional, Kawsar, Sarkar M.A., additional, Yasumitsu, Hidetaro, additional, Hamako, Jiharu, additional, Matsui, Taei, additional, and Ozeki, Yasuhiro, additional

Published
2011
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144. Malignant mediastinal germ cell tumors: Clinical findings and diagnostic and therapeutic problems

Author

Kitami, Akihiko, primary, Kamio, Yoshito, additional, Gen, Ryozo, additional, Suzuki, Kosuke, additional, Uematsu, Shugo, additional, Nakajima, Hiroaki, additional, Yamamoto, Shigeru, additional, Kataoka, Daisuke, additional, Kadokura, Mitsutaka, additional, Usuda, Ryosuke, additional, Nonaka, Makoto, additional, and Suzuki, Takashi, additional

Published
2010
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