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101. Cerebral abnormalities in cocaine abuser: demonstration by SPECT perfusion brain scintigraphy

Author

Tumeh, Sabah S., Nagel, J. Stevan, English, Robert J., Moore, Matthew, and Holman, B. Leonard

Subjects
Cocaine -- Adverse and side effects, SPECT imaging, Brain -- Abnormalities, Health
Abstract

Cocaine use can cause a number of physiological complications, including abnormalities in the cerebrum of the brain. The number of complications reported compared with the number of users is small, however, indicating that many have no symptoms early on. A noninvasive screening technique is important in early detection of complications arising from cocaine abuse. This study examined the use of single photon emission computed tomography (SPECT) perfusion scans in detecting cerebral abnormalities in 12 patients with histories of cocaine abuse. Five healthy controls were also examined. This technique involves injecting a contrasting agent, in this case iodine-123 isopropyl iodoamphetamine (IMP), into the subjects and then scanning them with a machine that takes many fine X-rays from different layers and positions in the brain and uses a computer to construct final images from the data obtained. Results revealed no abnormalities in the control group. On the other hand, focal defects were seen in the scans of 11 of the 12 patients. Eight of the patients had no symptoms yet seven of these eight had positive findings in the scans. Frontal lobe lesions were seen in seven patients, temporal lesions were seen in six patients, and parietal defects were seen in four patients. Severity of abnormalities as seen on SPECT scans corresponded fairly well with the extent of cocaine abuse. These results indicate that SPECT is sensitive in detecting brain abnormalities in cocaine users that are not symptomatic. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

102. Iofetamine I 123 single photon emission computed tomography is accurate in the diagnosis of Alzheimer's disease

Author

Johnson, Keith A., Holman, Leonard, Rosen, John, Nagel, J. Steven, English, Robert J., and Growdon, John H.

Subjects
Alzheimer's disease -- Diagnosis, PET imaging -- Evaluation, Health
Abstract

Alzheimer's disease (AD) is a chronic, organic mental disorder, or form of presenile dementia, in which the loss of intellectual function results from deterioration of the frontal and occipital lobes of the brain. It usually occurs between the ages of 40 and 60 years, and most commonly affects women. AD is characterized by the progressive, irreversible loss of memory, deterioration of intellectual function, indifference, speech and walking disorders, and disorientation. Within a few months to five years the disease may progress to complete loss of intellectual function. Brain function of patients with AD may be assessed by single photon emission computed tomography (SPECT), an imaging method using radioactive substances that release single photons or units of light energy. The effectiveness of SPECT using the radioactive substance iofetamine hydrochloride I 123 (IMP) in diagnosing AD was assessed in 58 patients with AD and 15 normal subjects. IMP with SPECT was 88 percent sensitive (identified individuals with AD) and 87 percent specific (identified individuals without AD) in diagnosing AD. The technique was 80 percent sensitive in identifying mild cognitive or intellectual abnormalities among 15 subjects without AD. IMP with SPECT showed that the parietal lobes of the brain were the most functionally impaired of all brain regions in patients with AD; this finding correlated with results from a cognitive function test known as the Blessed Dementia Scale. IMP with SPECT may serve as a useful, additional technique for diagnosing AD in the early, mild stage of the disease. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

111. Nachhaltiges Landmanagement im Norddeutschen Tiefland

Author

Spellmann, H., Ahrends, B., Albert, M., Andert, S., Barkmann, T., Böcher, M., Breckling, B., Christen, O., Dvorak, J., Eggers, M., Fleck, S., Fohrer, N., Gauly, M., Gerowitt, B., Gieseke, D., Grocholl, J., Hakes, W., Hammes, V., Hartje, V., Haunert, G., Hoffmann, M., Hufnagel, J., Isselstein, J., Kätzel, R., Kayser, M., Kehr, I., Knauer, H., Krott, M., Lambertz, C., Lange, A., Langer, G., Leefken, G., Löffler, S., Meesenburg, H., Meißner, Ralph, Messal, H., Meyer, P., Möhring, B., Möller, K., Nagel, J., Nuske, R., Oetzmann, A., Ohrmann, S., von Redwitz, C., Riediger, J., Schmidt, M., Schröder, J., Schröder, W., Siebert, R., Spindelndreher, D., Stahlmann, H., Stöck, L., Sutmöller, J., Svoboda, N., Tänzer, D., von Tiedemann, A., Ulber, B., Wegner, K., Werner, P.C., Winter, M., Wüstemann, H., Zander, P., Ziesche, T., Spellmann, H., Ahrends, B., Albert, M., Andert, S., Barkmann, T., Böcher, M., Breckling, B., Christen, O., Dvorak, J., Eggers, M., Fleck, S., Fohrer, N., Gauly, M., Gerowitt, B., Gieseke, D., Grocholl, J., Hakes, W., Hammes, V., Hartje, V., Haunert, G., Hoffmann, M., Hufnagel, J., Isselstein, J., Kätzel, R., Kayser, M., Kehr, I., Knauer, H., Krott, M., Lambertz, C., Lange, A., Langer, G., Leefken, G., Löffler, S., Meesenburg, H., Meißner, Ralph, Messal, H., Meyer, P., Möhring, B., Möller, K., Nagel, J., Nuske, R., Oetzmann, A., Ohrmann, S., von Redwitz, C., Riediger, J., Schmidt, M., Schröder, J., Schröder, W., Siebert, R., Spindelndreher, D., Stahlmann, H., Stöck, L., Sutmöller, J., Svoboda, N., Tänzer, D., von Tiedemann, A., Ulber, B., Wegner, K., Werner, P.C., Winter, M., Wüstemann, H., Zander, P., and Ziesche, T.

Abstract

Der Klimawandel und die Globalisierung der Märkte beeinflussen zunehmend unsere Gesellschaft. Ein zukunftsfähiges, nachhaltiges Landmanagement hat diesen Entwicklungen Rechnung zu tragen. Es muss sich neu ausrichten und dabei seine Ziele und Maßnahmen so konzipieren, dass es flexibel auf sich ändernde Rahmenbedingungen reagieren kann. Im Verbundprojekt „NaLaMa-nT“ wurden für das Norddeutsche Tiefland in den Modellregionen Diepholz, Uelzen, Fläming und Oder-Spree die Zustände analysiert, modellgestützt Entwicklungen abgeschätzt, Anpassungsnotwendigkeiten in der Land-, Forst- und Wasserwirtschaft aufgezeigt und transsektorale Kriterien und Indikatoren eines nachhaltigen Landmanagements identifiziert. Die Ergebnisse bieten Entscheidungshilfen, um potenzielle Interessenskonflikte auszugleichen und Anpassungsmaßnahmen sowie ein transsektorales Nachhaltigkeitsmonitoring zu initiieren. Sie schaffen belastbare Grundlagen für raumbezogene Planungen und Entscheidungen in Betrieben, Verwaltungen und der Politik.

Published
2017

112. Modeling the behavior of elastic materials with stochastic microstructure

Author

Nagel, J., Junker, P., Nagel, J., and Junker, P.

Abstract

Even in the simple linear elastic range, the material behavior is not deterministic, but fluctuates randomly around some expectation values. The knowledge about this characteristic is obviously trivial from an experimentalist’s point of view. However, it is not considered in the vast majority of material models in which “only” deterministic behavior is taken into account. One very promising approach to the inclusion of stochastic effects in modeling of materials is provided by the Karhunen-Lo`eve expansion. It has been used, for example, in the stochastic finite element method, where it yields results of the desired kind, but unfortunately at drastically increased numerical costs. This contribution aims to propose a new ansatz that is based on a stochastic series expansion, but at the Gauß point level. Appropriate energy relaxation allows to derive the distribution of a synthesized stress measure, together with explicit formulas for the expectation and variance. The total procedure only needs negligibly more computation effort than a simple elastic calculation. We also present an outlook on how the original approach in [7] can be applied to inelastic materials

Published
2017

113. Treatment with belimumab in systemic lupus erythematosus does not impair antibody response to 13-valent pneumococcal conjugate vaccine

Author

Nagel, J., Saxne, T., Geborek, P., Bengtsson, A. A., Jacobsen, S., Svaerke Joergensen, C., Nilsson, J. A., Skattum, L., Jönsen, A., Kapetanovic, M. C., Nagel, J., Saxne, T., Geborek, P., Bengtsson, A. A., Jacobsen, S., Svaerke Joergensen, C., Nilsson, J. A., Skattum, L., Jönsen, A., and Kapetanovic, M. C.

Abstract

Background/purpose The objective of this study was to explore the impact of systemic lupus erythematosus and belimumab given in addition to standard of care therapy on 13-valent conjugated pneumococcal vaccine (PCV13) response. Methods Forty-seven systemic lupus erythematosus patients and 21 healthy controls were immunized with a single dose of 13-valent conjugated pneumococcal vaccine. Forty systemic lupus erythematosus patients were treated with traditional disease-modifying anti rheumatic drugs, 11 of those received belimumab in addition, and 32 patients were treated with concomitant prednisolone. Quantification of serotype specific IgG levels to 12 pneumococcal capsular polysaccharides was performed in serum taken before and four to six weeks after vaccination using multiplex fluorescent microsphere immunoassay. IgG levels against serotypes 23F and 6B were also analyzed using standard enzyme-linked immunosorbent assays. Opsonophagocytic assay was performed on serotype 23F to evaluate the functionality of the antibodies. Pre- and post-vaccination log transformed antibody levels were compared to determine the impact of systemic lupus erythematosus diagnosis and different treatments on antibody response. Results Systemic lupus erythematosus patients as a group showed lower post-vaccination antibody levels and lower fold increase of antibody levels after vaccination compared to controls (p = 0.02 and p = 0.009, respectively). Systemic lupus erythematosus patients treated with belimumab in addition to standard of care therapy or with only hydroxychloroquine did not differ compared to controls, whereas the other treatment groups had significantly lower fold increase of post-vaccination antibody levels. Higher age was associated with lower post-vaccination antibody levels among systemic lupus erythematosus patients. Conclusion Belimumab given in addition to traditional disease-modifying anti rheumatic drugs or prednisolone did not further impair antibody response to

Published
2017

118. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and cirrhosis of the liver: A case report and literature review

Author

Kgomo, M K, Elnagar, A A, Jeske, C, and Nagel, J

Abstract

Patients with cirrhosis of the liver usually present with a small, shrunken liver and a large spleen. The presence of an unusually huge liver should prompt the treating doctor to look for another cause, as this may be treatable and improve the patient's outcome. In South Africa tuberculosis and lymphoma in the presence of HIV infection should be excluded. Sinus histiocytosis with massive lymphadenopathy and cirrhosis is a rare combination and has not been reported before in the literature. This case is intended to make clinicians aware of this rare combination of diseases.

Published
2016

119. Extensive Gastric Atrophy in Patients with Squamous Cell Carcinoma of the Oesophagus: A Descriptive Case Series

Author

Nagel J, Kgomo M, Mokoena T, and Elnagar A

Subjects
medicine.medical_specialty, Pathology, biology, business.industry, Gastric Atrophy, digestive, oral, and skin physiology, Cancer, Helicobacter pylori, Omics, medicine.disease, biology.organism_classification, Gastroenterology, digestive system diseases, 03 medical and health sciences, 0302 clinical medicine, Atrophy, 030220 oncology & carcinogenesis, Internal medicine, medicine, 030211 gastroenterology & hepatology, Basal cell, In patient, business, Antrum
Abstract

Recent studies in Sweden and Japan have reported that extensive gastric atrophy is associated with an increased risk for oesophageal squamous cell carcinoma. They also mentioned that this findings need to be confirmed in other ethnic groups due to the wide geographic variation of this cancer. Objectives: To determine the prevalence of extensive gastric atrophy in patients with squamous cell carcinoma of the oesophagus over a two year period. Method: Fifty nine patients with squamous cell carcinoma of the oesophagus referred to gastroenterology division for dilatation or stenting had four additional biopsies taken from the gastric antrum and corpus. This were then evaluated for the presence gastric atrophy and Helicobacter pylori by an experienced histopathologist. Results: Extensive gastric atrophy defined as atrophy of both the antrum and the corpus was found in 15(25%) of the fifty nine patients. Nine (60%) of these patients were also positive for Helicobacter pylori by methylene blue. Conclusion: The prevalence of extensive gastric atrophy in these patients with squamous cell carcinoma of the oesophagus is much lower than that found in Sweden and Japan, i.e. less than half of these two regions and the majority of them were found to be infected by h pylori. . This suggest that even though extensive gastric atrophy is an important factor in certain areas, it may be less important of a factor in South Africa and other geographic areas as shown in other studies. This still need to be investigated further in larger studies to fully understand the role of extensive gastric atrophy in these patients.

Published
2016

125. 68Ga-DATATOC: synthesis, radiolabeling, and first in vivo studies

Author

Waldron, B., Seemann, J., Bergmann, R., Nagel, J., Rösch, F., and Sinnes, J. P.

Abstract

Objectives: 68 Ga-DOTATOC is currently used as standard for diagnostic imaging of neuroendocrine tumors (NETs) and its metastases. Radiolabeling can be performed manually and automated at 95 °C. In order to approach application of 68 Ga following a kit-type procedure, a DATA-based chelator (6-Amino-1,4-diazepine-triacetate) was used as it has shown to radiolabel under very mild conditions. Conjugation with TOC may enable radiolabeling of the peptide at room temperature. Methods: DATATOC was synthesized in a seven step synthesis. Radiolabeling with 68 Ga was performed manually at room temperature and stability was assessed in human serum. An automated setup was also examined, using the Modular-Lab eazy (Eckert & Ziegler, Berlin, Germany). First in vivo studies using MPC-mCherry tumor bearing mice were performed and compared with 68 Ga-DOTATATE. Results: Radiolabeling was performed at room temperature using N2 solution, NaOAc-buffer and 14 nmol DATATOC. Within 3 min a RCY of 96.3 ± 1.2 % was obtained. Stability was tested in human serum over a period of 2 h (Δ = 1.3 %). Automated labeling with 23 nmol precursor achieved quantitative complexation of 68 Ga (> 99 %). In vivo PET/CT-studies with 68Ga-DATATOC indicate a high specific uptake in the tumor region after 10 min (SUV of 3.73 ± 1.49). In a blocking study with OC, the SUV in the tumor was reduced to 0.45 ± 0.15. In addition, 68 Ga-DATATOC showed high stability in mouse plasma with 93.7 % of the tracer remaining intact after 120 min. Compared to 68 Ga-DOTATATE a faster renal excretion of the tracer was observed. Conclusions: DATATOC can be labeled with 68 Ga in a manual or automated setup rapidly at room temperature, offering significant advantages over similar DOTA-based derivatives. Because of quantitative labeling yields, product purification is unnecessary. Furthermore, first in vivo studies confirm excellent targeting and excretion characteristics for the novel tracer. With the perspective towards a kit-type formulation, the superior characteristics of this new compound pave the way for a new generation of 68 Ga radiopharmaceuticals.

Published
2015

127. Risk factors for cefepime nonsusceptible Gram-negative infections in allogeneic hematopoietic cell transplant recipients.

Author

Boyd, A. M., Perissinotti, A. J., Nagel, J. L., Frame, D. G., and Marini, B. L.

Subjects
CROSS infection, GRAM-negative bacterial diseases, ACINETOBACTER infections, AGE distribution, DRUG resistance in microorganisms, GASTROINTESTINAL diseases, GRAFT versus host disease, HEMATOPOIETIC stem cell transplantation, LENGTH of stay in hospitals, MORTALITY, TRANSPLANTATION of organs, tissues, etc., ENVIRONMENTAL exposure, MULTIPLE regression analysis, RECEIVER operating characteristic curves, CEFEPIME, KLEBSIELLA infections, DISEASE risk factors
Abstract

Purpose Allogeneic hematopoietic cell transplant recipients undergo myelosuppressive chemotherapy to allow engraftment of stem cells and are at particularly high risk for bacterial infections and adverse outcomes. Patients undergoing hematopoietic cell transplant are at increased risk for healthcare-associated infections, including infections with multidrug-resistant pathogens. Cefepime is a commonly prescribed antibiotic for empiric therapy in hematopoietic cell transplant patients, but there is minimal data describing cefepime resistance rates, risk factors for resistance, and clinical outcomes associated with cefepime-resistant infections. Methods Adult (≥18 years old) allogeneic hematopoietic cell transplant recipients with a culture positive for a gram-negative rod between January 2010 and January 2016 were spilt into two groups: cefepime susceptible and cefepime nonsusceptible . The primary objective of this study was to identify risk factors for cefepime nonsusceptible through multivariable logistic regression. Results A total of 107 patients were included (27 cefepime nonsusceptible, 80 cefepime-susceptible), yielding a 25.2% nonsusceptibility rate. Multivariable analysis yielded age >60 years old, Klebsiella spp. infection, Acinetobacter spp. infection, healthcare exposures within 90 days, acute gastrointestinal graft-vs-host-disease, and chronic graft-vs-host-disease at multiple locations as significant risk factors for cefepime nonsusceptible. The receiver operating characteristic area under the curve of the model was 0.851. Thirty-day all-cause mortality (29.6% versus 16.3%, p = 0.13) and length of hospitalization (19 versus 12.5 days, p = 0.0650) were numerically higher in the cefepime nonsusceptible group. Conclusions Hematopoietic cell transplant patients with acute gastrointestinal graft versus host disease, extensive chronic graft-vs-host-disease, advanced age, previous healthcare exposures, or infections with Klebsiella and Acinetobacter are at increased risk for cefepime nonsusceptible. Patients infected with cefepime nonsusceptible pathogens may have higher rates of mortality and length of hospitalization. [ABSTRACT FROM AUTHOR]

Published
2019
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129. CHEK2*1100delC and susceptibility to breast cancer: A collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies

Author

Easton, D, McGuffog, L, Thompson, D, Dunning, AJ, Tee, L, Baynes, C, Healey, C, Pharoah, P, Ponder, BAJ, Seal, S, Barfoot, R, Sodha, N, Eeles, R, Stratton, MR, Rahman, N, Peto, J, Spurdle, AB, Chen, X, Chenevix-Trench, G, Hopper, JL, Giles, GG, McCredie, MRE, Syrjakoski, K, Holli, K, Kallioniemi, O-P, Eerola, H, Vahteristo, P, Blomqvist, C, Nevanlinna, H, Kataja, V, Mannermaa, A, Dork, T, Bremer, M, Deviljee, P, de Bock, GH, Krol-Warmerdam, EMM, Kroese-Jansema, K, Wijers-Koster, P, Cornelisse, CJ, Tollenaart, RAEM, Meijers-Heijboer, EJ, Berns, Els, Nagel, J, Foekens, John, Klijn, Jan, Schutte, Mieke, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE), Human Genetics, Clinical Genetics, and Medical Oncology

Subjects
Adult, LI-FRAUMENI-SYNDROME, PENETRANCE, Genotype, Breast Neoplasms, Protein Serine-Threonine Kinases, SDG 3 - Good Health and Well-being, Risk Factors, Odds Ratio, Genetics, Humans, Genetic Predisposition to Disease, BRCA2 MUTATIONS, skin and connective tissue diseases, Genetics (clinical), POPULATION, CHEK2, Aged, Sequence Deletion, RISK, WOMEN, Articles, Middle Aged, SERIES, GENE, Gene Expression Regulation, Neoplastic, Checkpoint Kinase 2, Genetics, Population, Case-Control Studies, Female, CHECKPOINT
Abstract

Previous studies of families with multiple cases of breast cancer have indicated that a frameshift alteration in the CHEK2 gene, 1100delC, is associated with an elevated frequency of breast cancer in such families, but the risk associated with the variant in other situations is uncertain. To evaluate the breast cancer risk associated with this variant, 10,860 breast cancer cases and 9,065 controls from 10 case-control studies in five countries were genotyped. CHEK2*1100delC was found in 201 cases (1.9%) and 64 controls (0.7%) (estimated odds ratio 2.34; 95% CI 1.72–3.20; P=.0000001). There was some evidence of a higher prevalence of CHEK2*1100delC among cases with a first-degree relative affected with breast cancer (odds ratio 1.44; 95% CI 0.93–2.23; P=.10) and of a trend for a higher breast cancer odds ratio at younger ages at diagnosis (P=.002). These results confirm that CHEK2*1100delC confers an increased risk of breast cancer and that this risk is apparent in women unselected for family history. The results are consistent with the hypothesis that CHEK2*1100delC multiplies the risks associated with susceptibility alleles in other genes to increase the risk of breast cancer.

Published
2004

130. Hodge number polynomials for nearby and vanishing cohomology

Author

Peters, C.A.M., Steenbrink, J.H.M., Nagel, J., Peters, C., Institut Fourier (IF ), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Chris Peters, Jan Nagel, Peters, Chris, Nagel, J., Peters, C., Institut Fourier (IF), and Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)

Subjects
14D07, [MATH.MATH-AG] Mathematics [math]/Algebraic Geometry [math.AG], Hodge character, Geometry, 32G20, Mathematics - Algebraic Geometry, Mathematics::Algebraic Geometry, motives, FOS: Mathematics, Hodge theory, [MATH.MATH-AG]Mathematics [math]/Algebraic Geometry [math.AG], Algebraic Cycles and Motives, Algebraic Geometry (math.AG), Mathematical Physics
Abstract

We recall the construction of the Hodge character and we show, using a result due to F. Bittner, that these can be constructed using classical pure Hodge theory only, sideskipping Deligne's construction of functorial mixed Hodge structures on the cohomology of algberaic varieties. We then give a proof, based on the weak factorization theorem, that the nearby fibre is well-defined in the Grothendieck group of varieties. Finally, various formulas for numerical invariants of Hodge-theoretic origin are presented which are associated to one-parameter degenerations of projective manifolds., 15 pages, contribution to Proceedings of "Algebraic cycles and motives", EAGER Conference 2004 Leiden University

Published
2007

137. [Ga-68]Ga-DATATOC imaging, biodistribution and kinetics in a pheochromocytoma model

Author

Bergmann, R., Ullrich, M., Ziegler, C., Waldron, B., Seemann, J., Nagel, J., Roesch, F., Eisenhofer, G., Steinbach, J., Pietzsch, J., Bergmann, R., Ullrich, M., Ziegler, C., Waldron, B., Seemann, J., Nagel, J., Roesch, F., Eisenhofer, G., Steinbach, J., and Pietzsch, J.

Abstract

Objectives The novel DATA (6-Amino-1,4-diazepine-triacetate) based octreotide derivative TOC allows radiolabeling at room temperature in contrast to DOTATOC that needs 95°C for effective labeling. The main goal of this study was to evaluate the potential of [68Ga]Ga-DATATOC for SSTR2 imaging in a syngeneic mouse pheochromocytoma (Pheo) model. Methods Radiolabeling of the DATATOC with 68Ga was performed manually at room temperature. The in vivo studies (PET, metabolic stability, biodistribution and elimination) were carried out in Pheo (MPC-mCherry) bearing mice and Wistar rats. For comparison the pheo were also imaged with [68Ga]Ga-DOTATOC and [68Ga]Ga-DOTATATE. Blocking studies in vivo were performed with octreotide (OC). Results The radiotracer showed high in vivo stability. A faster renal elimination of the radiotracer was observed in comparison to DOTATOC and DOTATATE. [68Ga]Ga-DATATOC showed fast, highly specific uptake in the pheo and the pancreas (SUV at 1 h p.i., tumor 3.7 ± 1.5, pancreas 0.57 ± 0.17), whereas blocking with OC (3.3 mg/kg body weight) reduced the uptake in the tumor to 0.45 ± 0.15 and Patlak analysis showed that both parameters - the influx rate and the distribution volume - were significantly decreased by OC. Conclusions [68Ga]Ga-DATATOC can be radiolabeled with 68Ga rapidly at room temperature with high radiochemical yields. The preclinical in vivo studies confirm the high stability, excellent specific targeting and fast elimination. This pharmacological profile and the perspective towards a kit-type formulation provide a great potential for diagnostic somatostatin receptor imaging. Research Support This work was supported by The Deutsche Forschungsgemeinschaft (Grants ZI-1362/2-1 [to C.G.Z. and G.E.] and BE-2607/1-1 [to R.B. and J.P.]).

Published
2015

138. Energie, water en afval: duurzame opties voor nieuw ziekenhuis Tergooi

Author

Hofman, J., Buijzer, E. de, Nagel, J., Houdt, W. van, Hofman, J., Buijzer, E. de, Nagel, J., and Houdt, W. van

Abstract

In het Park Monnikenberg bij Hilversum wordt een nieuw zorgpark ontwikkeld, waarin door Tergooi een nieuw ziekenhuis wordt gebouwd. Dit ziekenhuis moet zo duurzaam worden dat het een BREEAM®-certificaat ‘Excellent’ krijgt. In het kader van het TKI Watertechnologie is daarom de technische haalbaarheid van verschillende concepten op het raakvlak van water en energie onderzocht. De resultaten van deze studie kunnen worden gebruikt om een energiezuinig en duurzaam ziekenhuis te ontwerpen. De financieel-economische afweging werd gebaseerd op Total Costs of Ownership. Binnenkort wordt besloten welke concepten zullen worden toegepast.

Published
2015

141. De bereiding van vaccins

Author

Van Hemert, P. A., Van Der Marel, P., Nagel, J., Ruitenberg, E. J., Tiesjema, R. H., De Vries, F. A. J., and Van Wezel, A. L.

Published
1981
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144. Abstracts of papers Pharmaceutical and biomedical analysis meeting

Author

Bandhoe, A. U., Paalman, A. C. A., Underberg, W. J. M., Beijnen, J. H., Bekers, O., Otagiri, M., Bult, A., Beuman, Gert, van der Heijden, Jacques, Janss, Jenny, Ceelen, P. R. J., Feenstra-Bielders, G. G. L. M., Groeneveld, D. J., de Boer, D., Rutten, M. J. A., de Jong, E. G., Maes, R. A. A., van Rossum, J. M., de Groot, G., Kopps, R., Savelkoul, T. J. F., van Vloten, P., de Jonag, E. G., van Ooyen, R., Kiffers, J., de Kroon, I. F. I., Langendijk, P. N. J., de Goede, P. N. F. C., De Smet, M., Musch, C., Peeters, A., Buydens, L., Massart, D. L., De Turck, K., Cachet, Th., Hoogmartens, J., Delrue, M., Lannoo, P., Drenth, B. F. H., Beckeringh, F. J., Bosman, J., Feitsma, K. G., van Nijhuisvan Dam, A., Driebergen, R. J., van Gorp, J. A., Ensing, K., Farlam, A., de Jong, G. J., Frel, R. W., Brinkman, U. A. Th., Gerding, T. K., van de Grampel, V. J. M., Niemeijer, N. R., de Zeeuw, R. A., Tepper, P. G., Horn, A. S., Halvax, J. J., Wiese, G., van Bennekom, W. P., Hindriks, Rik, Buydens, Lutgarde, Peeters, Anne, de Smet, Marina, Massart, Luc, Blokland, Aric, Vink, Jan, Keizers, S., de Jong, E. G., Niessen, W. M. A., Verhey, E. R., LaVos, G. F., Tjaden, U. R., van der Greef, J., Ooms, J. A., Haak, G. S. J., Grooten, G., Pattyn, G., Sandra, P., David, F., van Oosterom, A. T., de Bruijn, E. A., Pouwelse, A. V., de Jong, D., Lammers, N. G. F. M., van den Berg, J. H. M., Quintens, I., Roets, E., Reeuwijk, H. J. E. M., Lingeman, H., Keizer, H. J., Rosing, H., Elferink, F., van de Vaart, F. J., Kloeg, P. H. A. M., Sauter, André, Stegehuis, D. S., Reinhoud, N. J., Steijger, O. M., Hilhorst, J. J. L., Holthuis, J. J. M., Underberg-Chitoe, U. K., Meenhorst, P. L., Van den Mooter, G., Hauchecorne, R., Vinckier, C., van der Horst, A., Martens, H. J. M., van der Horst, F. A. L., Post, M. H., van Ginkel, L. A., Zoontjes, P. W., van Blitterswijk, H., Stephany, R. W., van Gijn, R., Bakker, C. H., Koks, C. H. W., Rodenhuis, S., van Opstal, M. A. J., van den Horst, F. A. L., Krabbenborg, P., van Tellingen, O., Woude, H. R. v. d., van Beers, C. J. T., Nooyen, W. J., Varossieau, F. J., Los, G., Nagel, J. D., McVie, J. G., Veen, R. N., Land, J. T. Op 't, Vendrig, D. E. M. M., Teeuwsen, J., Verlaar, F. C. A. M., Trum, T. J. H. M., de Kleijn, J. P., Vervoort, R., Vrieling, M., Maris, F., Hindriks, H., Walhagen, A., Edholm, L. -E., Heeremans, C. E. M., and van der Hoeven, R. A. M.

Published
1989
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147. Onderzoek naar het effect van kinkhoestvaccinatie met twee DKTP-vaccins met verschillende concentraties van de kinkhoestcomponent

Author

Nagel J, Angulo-Laurent MS, Graaf S de, and Rumke HC

Subjects
dktp vaccin van verschillende sterkte, buitenmembraaneiwitten, fimbriae, 02, pertussis toxine, hemagglutinine, kinkhoest-antistofrespons
Abstract

De vorming van antistoffen in zuigelingen na vaccinatie met DKTP vaccins van verschillende sterkte werd onderzocht. Alle bepalingen werden met de zgn. ELISA uitgevoerd, waardoor het mogelijk werd de hoogte van antistofniveau's te bepalen tegen afzonderlijke componenten van de kinkhoestbacterie. Geconcludeerd kan worden dat de concentratie van de K-component in de DKTP-vaccins geen sterke invloed heeft op de hoogte van de antistofspiegels. Opnieuw werd vastgesteld dat na vaccinatie geen IgA antistoffen worden gevormd. De gevormde IgG antistoffen bleken o.a. tegen de buitenmenbraaneiwitten van de bacterie te zijn gericht. Het onderzoek werd uitgevoerd in samenwerking met de dienst Jeugdgezondheidszorg van de Provinciale Utrechtse Kruisvereniging.

Published
2012

148. A monoclonal anti-rat IgA antibody. Detection of IgA antibodies to ovalbumin and antigens of the parasite Trichinella spiralis in the rat

Author

van Loveren H, Osterhaus ADME, Nagel J, Hakkert B, de Klerk A, Drost G, and Vos JG

Subjects
vgz
Abstract

Dit rapport geeft de resultaten weer van de ontwikkeling van een monoclonaal antilichaam dat specifiek ratte IgA immunglobulinen herkent. IgA is een belangrijk immuunglobuline voor de bescherming van muscosale oppervlakken (o.a. op het niveau van de darm en de luchtwegen). Met behulp van het ontwikkelde reagens kunnen effecten van blootstelling aan schadelijke stoffen op de produktie van IgA worden vastgesteld, hetgeen van belang is om tot een nadere normstelling ten aanzien van deze stoffen te komen.

Published
2012

149. Dosis-effect relaties van geisoleerd en gezuiverd LPF (=lymphocytosis promoting factor) ten aanzien van cardiovasculair-farmacologische effecten in de rat

Author

Wildt DJ de, Jong Y de, Nagel J, Kuil A van de, and Blokhuijzen NJP

Subjects
autonome receptor gevoeligheid, vgz, bloeddruk, gezuiverd lpf
Abstract

In een onderzoek bij de rat zijn de effecten van verschillende LPF bevattende produkten op de bloeddruk en cardiovasculaire autonome receptorfuncties onderzocht. Met behulp van een farmacologische methode kon worden aangetoond dat de uit Bordetella pertussis geisoleerde en gezuiverde LPF in de Sepharose voorfracties 23+25/1 en 2/3 en 4/4 en het uiteindelijke produkt LPF 82/1 een dosisafhankelijke bloeddrukverlaging, vasculaire beta2-adrenerge hyporespons en een cardiale cholinerge blokkade gaf. Uit vergelijking van de verschillende dosis-effect relaties voor deze produkten kon worden afgeleid dat de detectielimiet voor LPF bepaald via deze methode tenminste 6-12 ng absoluut bedraagt. Het eindprodukt LPF 82/1 bleek in farmacologische activiteit circa een factor 5-10 keer minder actief te zijn dan de LPF bevattende voorfracties. Tenslotte kon worden aangetoond dat i.v. toediening een meer consistente en gevoeliger bepaling van LPF oplevert dan i.p. toepassing van LPF bevattende produkten.

Published
2012

150. Cardiovasculair-farmacologische effecten van een aantal Tn5 geinduceerde insertie-mutanten van Bordetella pertussis in de rat

Author

Wildt DJ de, Kuil A van de, Blokhuijzen NJP, and Nagel J

Subjects
insertiemutanten, vgz
Abstract

In een blind onderzoek bij de rat zijn de effecten van een zestal Transposon (Tn-5) insertiemutanten en de uitgangsstam van Bordetella pertussis op cardiovasculaire autonome receptoren en hemodynamiek onderzocht. Drie van deze mutanten (BP 347, 356 en 357) missen het vermogen om het toxische bestanddeel pertussis toxine te produceren. Met een cardiovasculair farmacologische methode kon worden aangetoond dat deze deletiemutanten geen of nauwelijks effecten hebben op vasculaire beta-adrenerge receptoren, cardiale cholinerge receptoren en de bloeddruk. De andere mutanten daarentegen hebben een sterke invloed op de autonome receptor functies (beta-adrenoceptor antagonerend en anticholinerg) en bloeddruk (hypotensie). Vergelijking met bestaande assays voor de detectie van pertussis toxine toont aan dat de farmacologische methode een zeer gevoelige, betrouwbare en kwantitatieve methode kan zijn voor de controle van cellulaire en acellulaire B.pertussis vaccins op de aanwezigheid van het toxische bestanddeel pertussis toxine.

Published
2012

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