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This paper aims to measure and compare the occupational stress level of teachers in central, state, and private universities of Assam, a large state located in Northeast India. It also intends to investigate the relative intensity of various stressors among the teachers. Administering a structured questionnaire-based survey, we collected data from 536 university teachers and analyzed it by deploying Kruskal-Wallis H- test. Our findings indicate that teachers in central universities experience a higher level of occupational stress than their counterparts in state and private universities. While teachers’ lack of control and student related issues are the critical stress sources in state and private universities, workload, excessive formalities, and lack of recognition are the major stressors in central universities. While unfolding the relative intensity of various stressors in different types of universities, the paper’s empirical findings contribute to stress research by offering insights into the stress issues encountered by university teachers.

Fenomena yang disebut “paradiplomacy” ini digunakan untuk mempercepat pelibatan kerjasama internasional dengan memberikan akses yang lebih besar di samping pemerintah Negara. Oleh karena itu, negara tidak lagi menjadi satu-satunya aktor, tetapi aktor lokal mulai mengambil alih dan berpartisipasi dalam kegiatan hubungan internasional untuk kepentingan aktor masing-masing. Konsep Sister City atau Twinning atau sering juga disebut kota kembar, merupakan kerjasama antar kota, yang secara formal disepakati dan mengikat sebagai sister city jangka panjang. Dalam konsep ini, isu apapun bisa menjadi tema kerjasama, termasuk isu lingkungan dan bencana. Perdebatan besar tentang paradiplomasi dalam studi IR muncul di sekolah Realis dan Konstruktivisme. Artikel ini mengkaji perspektif lain dalam hubungan internasional, yaitu Paradiplomacy dan Sister city, serta keterkaitan antara konsep-konsep kunci tersebut dengan meninjau artikel-artikel yang telah ditulis sebelumnya. Artikel ini dibagi menjadi beberapa bagian. Pertama, pengenalan bagaimana isu perubahan iklim dan konsep sister city di perkotaan dapat menjadi alternatif tindakan adaptasi dan mitigasi. Kemudian metodologi dan sumber data yang digunakan dalam makalah ini dijelaskan. Selanjutnya temuan-temuan tersebut akan dibahas dengan mengacu pada latar belakang teori. Terakhir, makalah ini menjabarkan beberapa kesimpulan dan implikasi kebijakan untuk peran sister city di AS-Jerman agar menjadi kota yang tahan dan tangguh dalam menghadapi risiko perubahan iklim. Kata Kunci: paradiplomasi; kota kembar; perubahan lingkungan

The purpose of this study was to determine the effect of promotion and ease of use partially andsimultaneously on customer loyalty at shopeefood service in Jakarta. The analytical method in thisstudy uses quantitative primary data, the stages carried out are: data quality test, classical assumptiontest, multiple linear regression analysis, t test (partial), f test (simultaneous), coefficient of determination(R2) using tools spss testing. The data used in this study were obtained by distributing questionnaires to100 respondents. The results of this study indicate that the promotion variable can partially andsignificantly affect customer loyalty at Shopeefood services in Jakarta. The ease of use variable partiallyand significantly can effect customer loyalty at ShopeeFood services in Jakarta. There is a simultaneousand significant influence between the variables of promotion and ease of use on customer loyalty atShopeeFood service in Jakarta.

The bromodomain family member proteins (BRD; BET proteins) are key coregulators for estrogen receptor alpha (ERα)-mediated transcriptional enhancers. The use of BRD-selective inhibitors has gained much attention as a potential treatment for various solid tumors, including ER-positive breast cancers. However, the roles of individual BET family members have largely remained unexplored. Here, we describe the role of BRDs in estrogen (E2)-dependent gene expression in ERα-positive breast cancer cells. We observed that chemical inhibition of BET family proteins with JQ1 impairs E2-regulated gene expression and growth in breast cancer cells. In addition, RNAi-mediated depletion of each BET family member (BRDs 2, 3, and 4) revealed partially redundant roles at ERα enhancers and for target gene transcription. Furthermore, we found a unique role of BRD3 as a molecular sensor of total BET family protein levels and activity through compensatory control of its own protein levels. Finally, we observed that BRD3 is recruited to a subset of ERα-binding sites (ERBS) that are enriched for active enhancer features, located in clusters of ERBSs likely functioning as “super enhancers,” and associated with highly E2-responsive genes. Collectively, our results illustrate a critical and specific role for BET family members in ERα-dependent gene transcription.Implications:BRD3 is recruited to and controls the activity of a subset ERα transcriptional enhancers, providing a therapeutic opportunity to target BRD3 with BET inhibitors in ERα-positive breast cancers.

Figure S1. The activity of BET family members is required for the growth of T-47D cells. Figure S2. BET proteins are required for E2-dependent gene expression in T-47D cells. Figure S3. JQ1 does not affect the expression of ERα, SRC2, and SRC3 in MCF-7 cells. Figure S4. JQ1 inhibits the E2-dependent expression of enhancer RNAs (eRNAs) in MCF-7 cells. Figure S5. E2-dependent Myc upregulation is not affected by JQ1. Figure S6. BET proteins are critical regulators of E2-dependent gene expression in T-47D cells. Figure S7. BRD3 is enriched at a subset of ERBSs. Figure S8. E2-induced genes affected by JQ1 are associated with ERα binding sites enriched with BRD3. Table S1. Gene ontologies associated with E2 up-regulated genes repressed by JQ1.

Supplementary Data from Oncohistone Mutations Occur at Functional Sites of Regulatory ADP-Ribosylation

Recent studies have identified cancer-associated mutations in histone genes that lead to the expression of mutant versions of core histones called oncohistones. Many oncohistone mutations occur at Asp and Glu residues, two amino acids known to be ADP-ribosylated (ADPRylated) by PARP1. We screened 25 Glu or Asp oncohistone mutants for their effects on cell growth in breast and ovarian cancer cells. Ectopic expression of six mutants of three different core histones (H2B, H3, and H4) altered cell growth in at least two different cell lines. Two of these sites, H2B-D51 and H4-D68, were indeed sites of ADPRylation in wild-type (unmutated) histones, and mutation of these sites inhibited ADPRylation. Mutation of H2B-D51 dramatically altered chromatin accessibility at enhancers and promoters, as well as gene expression outcomes, whereas mutation of H4-D68 did not. Additional biochemical, cellular, proteomic, and genomic analyses demonstrated that ADPRylation of H2B-D51 inhibits p300-mediated acetylation of H2B at many Lys residues. In breast cancer cell xenografts in mice, H2B-D51A promoted tumor growth, but did not confer resistance to the cytotoxic effects of PARP inhibition. Collectively, these results demonstrate that functional Asp and Glu ADPRylation sites on histones are mutated in cancers, allowing cancer cells to escape the growth-regulating effects of post-translational modifications via distinct mechanisms.Significance:This study identifies cancer-driving mutations in histones as sites of PARP1–mediated ADP-ribosylation in breast and ovarian cancers, providing a molecular pathway by which cancers may subvert the growth-regulating effects of PARP1.

Recent studies have identified cancer-associated mutations in histone genes that lead to the expression of mutant versions of core histones called oncohistones. Many oncohistone mutations occur at Asp and Glu residues, two amino acids known to be ADP-ribosylated (ADPRylated) by PARP1. We screened 25 Glu or Asp oncohistone mutants for their effects on cell growth in breast and ovarian cancer cells. Ectopic expression of six mutants of three different core histones (H2B, H3, and H4) altered cell growth in at least two different cell lines. Two of these sites, H2B-D51 and H4-D68, were indeed sites of ADPRylation in wild-type (unmutated) histones, and mutation of these sites inhibited ADPRylation. Mutation of H2B-D51 dramatically altered chromatin accessibility at enhancers and promoters, as well as gene expression outcomes, whereas mutation of H4-D68 did not. Additional biochemical, cellular, proteomic, and genomic analyses demonstrated that ADPRylation of H2B-D51 inhibits p300-mediated acetylation of H2B at many Lys residues. In breast cancer cell xenografts in mice, H2B-D51A promoted tumor growth, but did not confer resistance to the cytotoxic effects of PARP inhibition. Collectively, these results demonstrate that functional Asp and Glu ADPRylation sites on histones are mutated in cancers, allowing cancer cells to escape the growth-regulating effects of post-translational modifications via distinct mechanisms. Significance: This study identifies cancer-driving mutations in histones as sites of PARP1–mediated ADP-ribosylation in breast and ovarian cancers, providing a molecular pathway by which cancers may subvert the growth-regulating effects of PARP1.

Assessment is a fundamental aspect of learning and becomes a challenge in online learning in the area of disruption. Besides being able to improve the professional competence of educators, the proper application of e-assessment can help students to have the competencies needed in the 21st century. This study aims to develop an e-assessment design in entrepreneurial learning in Accounting Department Universitas Negeri Malang, Indonesia. This e-assessment, which is designed to assess students' knowledge, attitudes, and skills, becomes more efficient and transparent and is easily accessible to students. The results of this study are not only useful for lecturers in the process of designing e-assessments but also for undergraduate students of Accounting Education as prospective accounting educators so that they know in real-life contexts that can be learned and applied in educational courses. The development of the e-assessment design in this study can be used as a reference for other researchers in developing e-assessments in other subjects, but still must adapt it to the curriculum and learning system that applies at the university.

WA : 0853-1102-5193. Daftar Harga Jual Tempat Pemandian Jenazah Tigo Nagari (III Nagari). Terbukti AWET. Bahan Berkualitas. Full Stainless Steel. Anti Karat . Bisa menahan beban hingga 300 kg Bahan : Full Stainless Steel . KELEBIHAN BELANJA DI KAMI 1. Anti karat 2. Terbukti Awet Bertahun tahun 3. Full Stainless Steel 4. Bahan Berkualitas 5. BERGARANSI . Order Hubungi : WA 0853 1102 5193 https://wa.me/6285311025193 Web Official : Https://PabrikKeranda.co.id . Pabrik Tempat Pemandian Jenazah Tigo Nagari (III Nagari), Tempat Pemandian Mayat Stainless Tigo Nagari (III Nagari), Ukuran tempat pemandian jenazah Tigo Nagari (III Nagari), Tempat Memandikan Jenazah Tigo Nagari (III Nagari), Tempat Memandikan Jenazah Stainless Tigo Nagari (III Nagari), Tempat Pemandian Mayat Stainless Tigo Nagari (III Nagari), Jual Tempat Pemandian Jenazah Tigo Nagari (III Nagari), ukuran tempat memandikan jenazah Tigo Nagari (III Nagari), tempat memandikan jenazah menurut islam Tigo Nagari (III Nagari), tempat pemandian jenazah dari stainless Tigo Nagari (III Nagari), Tempat Memandikan Mayat Tigo Nagari (III Nagari), Tempat Pemandian Jenazah Tigo Nagari (III Nagari), Tempat Untuk Memandikan Mayat Tigo Nagari (III Nagari), Pemandian Mayat Tigo Nagari (III Nagari), Tempat Mandi Mayat Stainless Tigo Nagari (III Nagari), Tempat Mandi Jenazah Tigo Nagari (III Nagari), Tempat Mandi Jenazah Stainless Steel Tigo Nagari (III Nagari), Jual Tempat Mandi Jenazah Tigo Nagari (III Nagari), Tempat Pemandian Mayat Tigo Nagari (III Nagari), Tempat Memandikan Jenazah Tigo Nagari (III Nagari) Tigo Nagari (III Nagari), Tempat Untuk Memandikan Jenazah Tigo Nagari (III Nagari), Jual Tempat Memandikan Jenazah Tigo Nagari (III Nagari), Pemandian Mayat Stainless Tigo Nagari (III Nagari), Pemandian Mayat Stenlis Tigo Nagari (III Nagari), Tempat Mandi Mayat Tigo Nagari (III Nagari), bak pemandian jenazah Tigo Nagari (III Nagari), bak pemandian mayat Tigo Nagari (III Nagari), bak untuk memandikan jenazah Tigo Nagari (III Nagari), gambar tempat memandikan jenazah Tigo Nagari (III Nagari), harga tempat memandikan jenazah stainless Tigo Nagari (III Nagari), berapa harga tempat pemandian jenazah Tigo Nagari (III Nagari), daftar harga tempat pemandian jenazah Tigo Nagari (III Nagari), harga tempa memandikan jenazah Tigo Nagari (III Nagari), tempat pemandian jenazah sesuai ppi Tigo Nagari (III Nagari)

WA : 0853-1102-5193. Daftar Harga Jual Tempat Pemandian Jenazah Ampek Nagari (IV Nagari ). Terbukti AWET. Bahan Berkualitas. Full Stainless Steel. Anti Karat . Bisa menahan beban hingga 300 kg Bahan : Full Stainless Steel . KELEBIHAN BELANJA DI KAMI 1. Anti karat 2. Terbukti Awet Bertahun tahun 3. Full Stainless Steel 4. Bahan Berkualitas 5. BERGARANSI . Order Hubungi : WA 0853 1102 5193 https://wa.me/6285311025193 Web Official : Https://PabrikKeranda.co.id . Pabrik Tempat Pemandian Jenazah Ampek Nagari (IV Nagari ), Tempat Pemandian Mayat Stainless Ampek Nagari (IV Nagari ), Ukuran tempat pemandian jenazah Ampek Nagari (IV Nagari ), Tempat Memandikan Jenazah Ampek Nagari (IV Nagari ), Tempat Memandikan Jenazah Stainless Ampek Nagari (IV Nagari ), Tempat Pemandian Mayat Stainless Ampek Nagari (IV Nagari ), Jual Tempat Pemandian Jenazah Ampek Nagari (IV Nagari ), ukuran tempat memandikan jenazah Ampek Nagari (IV Nagari ), tempat memandikan jenazah menurut islam Ampek Nagari (IV Nagari ), tempat pemandian jenazah dari stainless Ampek Nagari (IV Nagari ), Tempat Memandikan Mayat Ampek Nagari (IV Nagari ), Tempat Pemandian Jenazah Ampek Nagari (IV Nagari ), Tempat Untuk Memandikan Mayat Ampek Nagari (IV Nagari ), Pemandian Mayat Ampek Nagari (IV Nagari ), Tempat Mandi Mayat Stainless Ampek Nagari (IV Nagari ), Tempat Mandi Jenazah Ampek Nagari (IV Nagari ), Tempat Mandi Jenazah Stainless Steel Ampek Nagari (IV Nagari ), Jual Tempat Mandi Jenazah Ampek Nagari (IV Nagari ), Tempat Pemandian Mayat Ampek Nagari (IV Nagari ), Tempat Memandikan Jenazah Ampek Nagari (IV Nagari ) Ampek Nagari (IV Nagari ), Tempat Untuk Memandikan Jenazah Ampek Nagari (IV Nagari ), Jual Tempat Memandikan Jenazah Ampek Nagari (IV Nagari ), Pemandian Mayat Stainless Ampek Nagari (IV Nagari ), Pemandian Mayat Stenlis Ampek Nagari (IV Nagari ), Tempat Mandi Mayat Ampek Nagari (IV Nagari ), bak pemandian jenazah Ampek Nagari (IV Nagari ), bak pemandian mayat Ampek Nagari (IV Nagari ), bak untuk memandikan jenazah Ampek Nagari (IV Nagari ), gambar tempat memandikan jenazah Ampek Nagari (IV Nagari ), harga tempat memandikan jenazah stainless Ampek Nagari (IV Nagari ), berapa harga tempat pemandian jenazah Ampek Nagari (IV Nagari ), daftar harga tempat pemandian jenazah Ampek Nagari (IV Nagari ), harga tempa memandikan jenazah Ampek Nagari (IV Nagari ), tempat pemandian jenazah sesuai ppi Ampek Nagari (IV Nagari )

Shalama Lekasa Nagari,1 Gudina Egata,2 Ame Mehadi,3 Tahir Ahmed Hassen,3 Temam Beshir Raru,3 Mohammed Abdurke,3 Mohammed Yuya,3 Shemsedin Abdulkadir,4 Hiwot Berhanu,3 Kedir Teji Roba3 1College of Health Sciences, Assosa University, Assosa, Ethiopia; 2College of Health and Medical Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 3College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 4College of Health and Medical Sciences, Arsi University, Asella, Oromia, EthiopiaCorrespondence: Ame Mehadi, School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia, Tel +251919118839, Fax +251256668081, Email mehadiame1554@gmail.comBackground: Anemia affects more than a quarter of non-pregnant women over the globe, with Sub-Saharan Africa bearing a disproportionate share. Although the use of family planning is beneficial in reducing anemia, lack of scientific study on anemia among family planning users of reproductive-age women is notable, particularly in the study setting. The purpose of this study was to determine the extent of anemia and associated factors in women who used family planning.Methods: A cross-sectional multi-centered study was conducted from March 3 to 29, 2019, among 443 non-pregnant reproductive age (15 to 49 years) women receiving family planning services in Ambo town. Sample size was calculated using Epi-info version 7 software. Participants were selected by systematic random sampling technique. Trained data collectors collected data using a structured pretested questionnaire, as well as venous blood and stool samples. Epi-Data and SPSS were used to enter and analyze data. The effect of independent variables on the outcome variable was determined by binary logistic regression analysis with adjusted odds ratio at 95% confidence interval and 5% margin of error. P-value < 0.05 was used to declare statistical significance.Results: This study revealed 28% (95% CI:23.9%, 32.3%) magnitude of anemia. Age of 25– 35 years [AOR:2.84, 95% CI:1.74, 4.64], implantable family planning method [AOR: 0.34, 95% CI: 0.12, 0.96], no previous use of family planning [AOR:2.62, 95% CI: 1.62, 4.24], household food insecurity [AOR: 2.04, 95% CI: 1.06, 3.93], parasite infestations [AOR:2.01, 95% CI: 1.12, 3.63], and regular intake of coffee/tea within 30 minutes post meal [AOR:3.85, 95% CI:1.24, 11.92] were independently associated with anemia.Conclusion: Anemia is a moderate public health concern among reproductive-age women receiving family planning services in the study area. There are missed opportunities to address the anemia burden during family planning services. This study emphasizes the importance of nutritional screening for early detection and targeted interventions for healthcare workers in reducing missed opportunities to prevent and control anemia in vulnerable populations.Keywords: anemia, family planning, reproductive age women, Ambo, Ethiopia

The challenge in realizing quality education requires educators to be more creative, innovative, and inspiring in designing learning activities. This is carried out as well as preparation to welcome Indonesia's golden generation in 2045. In addition, in the accounting world, the role of educator accountants is very important to form reliable millennial accountants with high competitiveness. This research is a media development research that raises the incorporation of interactive media using the word square learning model with the aim of facilitating the understanding of accounting material for students so that it can motivate students to be enthusiastic about learning and obtain maximum learning outcomes. Learning activities through interactive media are learning using technology-based tools. Meanwhile, the model in word square learning is a learning model with the same level of similarity as the crossword puzzle learning model. In word square learning, answers are available but they are disguised using the addition of letters or numbers, as well as the addition of boxes as a distraction with the aim of training students' critical and conscientious attitude. The method in this study, namely the research and development method of the ADDIE model. Based on the research results that have been obtained, it can be concluded that the learning process is more interesting if it uses a combination of technology-based interactive media with the word square model. This research reaches the design stage of the application to be developed. This research can be improved later with practical trials in the field on students in the classroom.

Mother’s knowledge about risk factors of stunting are one of many efforts to prevent stunting. Health promotion could contribute to increase level of knowledge about stunting. Commonly used methods are video and speech. This study was conducted to compare effectiveness of health promotion using video and metaphor to level of knowledge of pregnant woman about stunting in Palembang. This sudy was a quasi-experimental nonequivalent control group pretest-posttest. Population are pregnant woman in Palembang. Samples was obtained by purposive sampling. The research data was collected by questionnaire. Pretest and posttest data was analyzed by Wilcoxon. Effectiveness of health promotion method valued by difference of pretest and posttest score between methods using Mann Whitney. Result of the study was significantly increasing knowledge of pregnant woman about stunting after health promotion (p=0,000). The most effective method of health promotion is video with p-value 0,05. Health promotion could increase knowledge of pregnant woman about stunting. Effective method for health promotion was video better than metaphor.

PurposeThe paper presents a structural model to explain the relationship between various gender-role orientations (GROs) and motivational antecedents leading to entrepreneurial intention (EI). It examines the influence of GRO in the formation of EI among educated youths of Northeast India.Design/methodology/approachUsing a structural equation modelling approach, the hypothesized model is tested on a sample of 642 post-graduate students from four different universities in Northeast India, a developing region with unique socio-cultural diversity. The mediating role of EI antecedents on the relationship between GRO and EI was examined after establishing the reliability and validity of the measurement model.FindingsResults from the analysis support the hypothesized structural relationship confirming the influence of GRO on EI. The study also finds that androgynous individuals have a higher EI than their masculine or feminine counterparts.Research limitations/implicationsThe study contributes to the understanding of EI determinants from a GRO perspective, especially in the industrially backward region of an emerging economy. It adds to the existing literature by empirically proving the role of gender orientation. The results have several policy implications for educational institutions and policymakers in emerging economies.Originality/valueThe paper re-examines the predictive value of the theory of planned behaviour (TPB) model from a GRO perspective and compares indirect effects of gender identity through motivational antecedents on EI. Whilst TPB predicted EI in Western and developed countries, using a more diverse sample provides strong empirical evidence in the context of a developing region.

Purpose The study aims to investigate the mediation effect of the Audit Committee’s (AC) effectiveness on the relationship between knowledge intensity and firm performance (FP) by considering the disparate effect of each AC characteristic on its effectiveness. Design/methodology/approach The study uses the partial least squares-structural equation model (PLS-SEM) to weigh the AC characteristics for its effectiveness and analyzes the relationships between the variables included in the models. Data was collected from authentic sources for 133 National Stock Exchange (NSE)-listed companies in six industries covering the period 2016 to 2020. Findings The results indicate that eight out of eleven AC characteristics, namely, nonexecutive directors, independence, expertise, AC-charter, multiple directorships, frequency of AC meetings, attendance of AC meetings and board meetings by AC directors, significantly influence the AC effectiveness while mediating the relationship between knowledge intensity and FP. Further, each characteristic of AC has a disparate effect on AC effectiveness depending on the measurement context. Research limitations/implications Apart from guiding the policymakers, management and stakeholders to effectively use AC characteristics in enhancing FP, this study further contributes to the literature by providing a new way to weight AC characteristics based on their individual contributions; and exploring new path models to analyze the multidimensional effect of various AC characteristics. Originality/value To the best of the authors’ knowledge, the study is the first to examine the mediation role of AC effectiveness on the relationship between the knowledge intensity of the firms and their performance. It demonstrates improvisation in measuring AC effectiveness using the disparate weights for each AC characteristic, computed based on their relative contribution to AC effectiveness.