Search

Abstract Mixtures of 1-acylmethylpyridinium halides with equimolar amounts of pyridinium halides were prepared by the Ortoleva-King reaction. The inhibiting effect of various pyridinium halides and their mixtures on corrosion of steel in sulfuric acid solutions was studied. [ABSTRACT FROM AUTHOR]

Depression is highly prevalent in primary care (PC) settings. While extensive efforts are directed at optimization of depression screening practices, rates remain suboptimal, and barriers continue to be poorly understood. The present study investigated screening-related practices and beliefs. A concurrent mixed-methods approach was utilized to obtain both quantitative and qualitative data. Participants ( N = 36) completed a self-report survey and a brief semistructured interview to assess attitudes toward depression screening, knowledge/beliefs about screening, as well as administration practices and screening-related training. Despite low rates of training (52.8%), participants endorsed understanding of the purpose, scope, and specialty populations targeted for screening. 83.3% of the sample assisted patients with screening completion. Rephrasing and reading the screening items were common and (with exception of reading the paper form) were associated with higher reported screening-related barriers ( p < .05). Perceived importance of screening scores was significantly, positively associated with screening-related competence scores ( r = .50, n = 35, p < .01). Qualitative data analysis revealed that screening may be conducted on a case-by-case basis or deferred based on perception of clinical relevance and time constraints. Finally, participants endorsed multiple screening-related questions and concerns about administration, psychometrics, and overarching screening goals. To improve implementation of universal depression screening, goals of depression screening need to be clearly explained. Screening workflows require optimization balancing employees' feedback and best practice recommendations. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

We present an improved measurement of the carbon-nitrogen-oxygen (CNO) solar neutrino interaction rate at Earth obtained with the complete Borexino Phase-III dataset. The measured rate, R&#95;{CNO}=6.7&#95;{-0.8}^{+2.0}  counts/(day×100  tonnes), allows us to exclude the absence of the CNO signal with about 7σ C.L. The correspondent CNO neutrino flux is 6.6&#95;{-0.9}^{+2.0}×10^{8}  cm^{-2} s^{-1}, taking into account the neutrino flavor conversion. We use the new CNO measurement to evaluate the C and N abundances in the Sun with respect to the H abundance for the first time with solar neutrinos. Our result of N&#95;{CN}=(5.78&#95;{-1.00}^{+1.86})×10^{-4} displays a ∼2σ tension with the "low-metallicity" spectroscopic photospheric measurements. Furthermore, our result used together with the ^{7}Be and ^{8}B solar neutrino fluxes, also measured by Borexino, permits us to disfavor at 3.1σ C.L. the "low-metallicity" standard solar model B16-AGSS09met as an alternative to the "high-metallicity" standard solar model B16-GS98.

The guidance presented here will help you to counsel patients and work with other caregivers in a biopsychosocial approach.

We report the measurement of sub-MeV solar neutrinos through the use of their associated Cherenkov radiation, performed with the Borexino detector at the Laboratori Nazionali del Gran Sasso. The measurement is achieved using a novel technique that correlates individual photon hits of events to the known position of the Sun. In an energy window between 0.54 to 0.74 MeV, selected using the dominant scintillation light, we have measured 10 887&#95;{-2103}^{+2386}(stat)±947(syst) (68% confidence interval) solar neutrinos out of 19 904 total events. This corresponds to a ^{7}Be neutrino interaction rate of 51.6&#95;{-12.5}^{+13.9}  counts/(day·100  ton), which is in agreement with the standard solar model predictions and the previous spectroscopic results of Borexino. The no-neutrino hypothesis can be excluded with >5σ confidence level. For the first time, we have demonstrated the possibility of utilizing the directional Cherenkov information for sub-MeV solar neutrinos, in a large-scale, high light yield liquid scintillator detector. This measurement provides an experimental proof of principle for future hybrid event reconstruction using both Cherenkov and scintillation signatures simultaneously.

Depression is highly prevalent in primary care settings, but screening rates remain sub-optimal and patients' screening perspectives are poorly understood. This study examined depression screening experiences and beliefs among primary care patients (N = 100, M age  = 51.9, SD = 17.03, 49% Spanish speakers). Participants completed a survey regarding screening experiences, stigma concerns, and perceptions of screening-related importance, barriers, and concerns. While 83% of participants were screened for depression, only 44.6% had screening results explained. Levels of depression treatment-related stigma concerns were low, with English speakers endorsing higher levels of such concerns. Importance and barriers of screening scores were significantly, negatively correlated r s  = - .52, p < .001. Patients' self-identification as 'long-standing' to the clinic was associated with greater endorsed screening concerns t(98) =  - 2.08, p < .05. Results suggest that improved understanding of patients' screening-related perceptions and experiences is critical to ensuring delivery of quality care. Communication practices around screening should be studied, reviewed, and revised to ensure the success of screening efforts., (© 2020. Springer Science+Business Media, LLC, part of Springer Nature.)

Alginate-based hydrogels can find uses in a wide range of applications, including in the encapsulation field. This type of hydrogels is usually ionically crosslinked using calcium sources giving rise to products with limited internal crosslinking. In this work, it is hypothesized that the combination of alginate crosslinked by calcium chloride (external crosslinking; ionic mechanism) with gelatin crosslinked by transglutaminase (internal crosslinking; enzymatic induced mechanism) can be used to tailor the swelling behavior of alginate-based hydrogel microspheres. A systematic study was conducted by covering process variables such as gelatin content, TGase concentration, and CaCl 2 contact time, added by statistic tools as central composite rotatable design (CCRD), principal component analysis (PCA) and multiobjective optimization, to map their effect on the resulting water content after production (expressed as swelling ratio), and swelling properties at pH 3 and 7. Among the studied variables, particle's swelling was mostly affected by the gelatin content and transglutaminase concentration., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

This study examined the ability of several human pharmaceuticals to modulate hepatic piscine CYP-mediated monooxygenase activities. Effects of six pharmaceuticals: diclofenac, sulfamethoxazole, tramadol, carbamazepine, venlafaxine and nefazodone, were investigated in vitro in rainbow trout hepatic microsomes. The reactions of 7-ethoxyresorufin-O-deethylase (EROD) and benzyloxy-4-trifluoromethylcoumarin-O-debenzyloxylase (BFCOD), were used as markers for hepatic CYP1A and CYP3A-like activities, respectively. Our results showed that EROD and BFCOD activities were both affected by nefazodone. Nefazodone inhibited EROD in a dose dependent manner and was found to be a potent non-competitive inhibitor of EROD with a K i value of 6.6 μM. BFCOD activity was inhibited non-competitively in the presence of nefazadone with K i value of 30.7 μM. BFCOD activity was slightly reduced only by the highest concentration of carbamazepine. Diclofenac, sulfamethoxazole, tramadol, and venlafaxine did not affect the activity of either EROD or BFCOD. We further exposed microsomal fraction to mixtures of six pharmaceuticals to investigate potential inhibition. The results showed that EROD and BFCOD activity was inhibited on 94% and 80%, respectively at higher tested concentration. To our knowledge, this is the first report to demonstrate an inhibitory effect of nefazodone on hepatic CYP1A and CYP3A-like proteins in rainbow trout., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Warfarin is a commonly used anticoagulant drug and is a derivate of coumarin. Cytochrome P450 2C9 (CYP2C9) plays the key role in transformation of coumarin and thus, influences determination of warfarin dosage. A number of factors including dietary compounds such as sesamin, caffeic acid and ferulic acids can regulate the activity of CYP2C9. The present study tested the hypothesis that sesamin, episesamin, caffeic acid and ferulic acid decreases the rate of warfarin 7-hydroxylation via inhibition of hepatic CYP2C9. The experiments were conducted on hepatic microsomes from human donors. It was demonstrated that the rate of 7-hydroxylation of warfarin was significantly decreased in the presence of sesamin in the range of concentrations from 5 to 500 nM, and was not affected by episesamin, caffeic acid and ferulic acid in the same range of concentrations. The kinetic analysis indicated non-competitive type of inhibition by sesamin with Ki = 202 ± 18 nM. In conclusion, the results of our in vitro study revealed that sesamin was able to inhibit formation of a major metabolite of warfarin, 7-hydroxywarfarin. The potentially negative consequences of the consumption of high amounts of sesamin-containing food or dietary supplements in warfarin-treated patients need to be further studied., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Phytochemicals are widely present in fruits, vegetables and other plants and have great health benefits owing to their antioxidant properties. They are naturally found in the aquatic environment as well as discharged from sewage treatment plants after their large consumption. Little is known about their impact on fish; particularly in light of their interactions with pharmaceuticals. Therefore, this study was designed to determine the effects of diosmin, naringenin, quercetin and idole-3-carbinol on CYP1A-dependent 7-ethoxyresorufin-O-deethylase (EROD) activity on rainbow trout hepatic microsomes in the presence of two pharmaceuticals: clotrimazole and dexamethasone. The interactions between the phytochemicals and pharmaceuticals used in this study were determined using a combination index. Hepatic microsomes were exposed to two concentrations (1-or 50 μM) of phytochemicals and pharmaceuticals separately and in combinations. Singly, clotrimazole inhibited EROD activity 40% and 90% of control, while dexamethasone did not. Naringenin and diosmin inhibited EROD activity alone up to 90% and 55% respectively, but activities were further inhibited in the presence of either pharmaceutical. The preliminary study of combinations of clotrimazole with phytochemicals primarily showed synergistic effects. While EROD activity was not inhibited in the presence of quercetin or indole-3-carbinol, significant and synergistic inhibition was detected when either of these was combined with clotrimazole or dexamethasone., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Background: Inclusion of patient satisfaction scores in setting reimbursements has been suggested by health care policy makers to contain cost and improve outcomes. The Short Form 36 Health Survey (SF-36) score provides a health-related quality of life (HRQoL) measure of arthroplasty outcome. Although previous work identified factors that influence this score for hip and knee arthroplasty patients, they did not focus on how a surgeon might use this information in a clinical setting. The present study examined whether relatively simple criteria might identify patients more likely to experience minimal HRQoL improvement., Methods: "Improvements" in SF-36 composite physical scores and subscales were calculated from the difference between initial (preoperative) and SF-36 scores at 1 year. The rates of achieving a clinically significant improvement were compared between patient groups., Results: After knee arthroplasty, women and younger patients achieved a clinically significant improvement in physical function more frequently than men and older patients (P = .04 and .02, respectively). The largest differences in improvement occurred between the diabetic and nondiabetic groups (P = .001), where the diabetic patients with ≥2 additional comorbidities demonstrated the lowest rate of achieving a clinically significant improvement in physical function and bodily pain. In comparison, in hip patients only age had significant influence on gains in physical function, but this did not alter the rate at which patients achieved a clinically significant improvement., Conclusion: These data indicate simple screening criteria can identify patients where arthroplasty might provide marginal HRQoL improvement. They suggest HRQoL-based reimbursement incentives will favor practices with younger, healthier patient populations., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Cytochrome P450 proteins (CYP450s) are present in most domains of life and play a critical role in the metabolism of endogenous compounds and xenobiotics. The effects of exposure to xenobiotics depend heavily on the expression and activity of drug-metabolizing CYP450s, which is determined by species, genetic background, age, gender, diet, and exposure to environmental pollutants. Numerous reports have investigated the role of different vertebrate CYP450s in xenobiotic metabolism. Model organisms provide powerful experimental tools to investigate Phase I metabolism. The aim of the present review is to compare the existing data on human CYP450 proteins (1-3 families) with those found in pigs, mice, and fish. We will highlight differences and similarities and identify research gaps which need to be addressed in order to use these species as models that mimic human traits. Moreover, we will discuss the roles of nuclear receptors in the cellular regulation of CYP450 expression in select organisms., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

The aim of the present study was to evaluate in vitro effects of dietary phytochemicals naringenin, quercetin, and sesamin on the activities of ethoxy- (EROD; CYP1A) and benzyloxy- (BROD; CYP3A) resorufin O-dealkylases after the exposure to the cocktail of persistent organic pollutants (POPs). CD-1 mice were exposed from weaning, through gestation and lactation to a defined mixture of POPs. Hepatic microsomes were prepared from their female offspring at postnatal day 42. Hepatic EROD and BROD activity were evaluated in the presence of quercetin, naringenin, and sesamin at nine concentrations from 5 to 100000 nM. EROD activity was strongly inhibited by quercetin with Ki values from 1.7 to 2.6  μ M. BROD activity was inhibited by quercetin with Ki values from 64.9 to 75.3  μ M and naringenin with Ki values from 39.3 to 45.8  μ M. The IC 50 and Ki values did not differ between the groups of mice with different levels of POPs exposure in any of the experimental sets. Sesamin did not inhibit either EROD or BROD. We concluded that the interactions of quercetin and naringenin with CYP1A and CYP3A in mice liver were not affected by the levels of POPs exposure.

The impact of psychiatric illnesses upon asthma patients' functioning is not well understood. This study examined the impact of psychiatric comorbidity upon illness management in asthma patients using empirically-derived psychiatric comorbidity groups. Participants were a clinic sample of Greek-speaking asthma patients (N = 212) assessed using the Patient Health Questionnaire (PHQ) Somatoform, Depression, Panic Disorder (PD), Other Anxiety Disorder, Eating Disorder (ED) and Alcohol sub-scales. The associations between sub-scales were examined using multiway frequency analysis. The following groups were derived: Somatoform disorder and/or Any Depressive disorder (n = 63), Somatoform disorder and/or Other Anxiety disorder (n = 51), Somatoform disorder and/or Any ED (n = 60), and Any Anxiety group including PD and/or Other Anxiety disorder (n = 24). Across all groups, psychiatric illness was associated with significantly worse asthma control (p < .01). Participants in Any Anxiety group, OR = 4.61, 95% CI [1.90, 11.15], Somatoform and/or Any Depressive disorder, OR = 2.06, 95% CI [1.04, 4.09] and Somatoform and/or Other Anxiety disorder, OR = 2.75, 95% CI [1.35, 5.60] were at higher risk for asthma-related Emergency Room (ER) visits compared to controls. However only Somatoform and/or Any Depressive disorder, OR = 3.67, 95% CI [1.60, 8.72], Somatoform and/or Other Anxiety disorder, OR = 5.50, 95% CI [2.34, 12.74], and Somatoform and/or Any ED, OR = 4.98, 95% CI [2.14, 11.60] group membership were risk factors for asthma-related hospitalizations. Results suggest that while comorbid psychiatric disorders generally negatively impact asthma illness management, different psychiatric comorbidities appear to have disparate effects upon illness management outcomes.

This study aimed to assess the reliability, validity, and factor structure of the Greek translation of the Patient Health Questionnaire (PHQ) in a sample of Cypriot, Greek-speaking university students. This is the first study to examine PHQ psychometric properties in Greek and to investigate the factor structure of the PHQ subscales. A total of 520 participants (73.9% women; M(Age) = 21.57; SD, 4.94) completed the PHQ and assessment tools used for convergent validity analysis. Patient Health Questionnaire was translated and culturally adapted according to international standards. Overall, PHQ subscales in Greek language demonstrated good internal consistency (mean Cronbach α = .75, P < .001) and convergent validity with the following: Alcohol Use Disorders Identification Test, Beck Depression Inventory, Psychiatric Diagnostic Screening Questionnaire (panic disorder, somatization, bulimia, and binge eating), and Anxiety Sensitivity Index (overall mean, r = 0.52; P < .001). The relation between the PHQ subscale diagnoses and functional impairment, as assessed by the 12-item Health Survey 12, was comparable with the original validation results for all subscales except alcohol. The depression, alcohol, and anxiety subscales exhibited single-factor structures. Subscales assessing eating disorders, panic disorder, and somatization difficulties exhibited 2-, 3-, and 4-factor structures, respectively. Overall, PHQ subscales demonstrated good psychometric properties, with the exception of the subscale examining problematic alcohol use. Overall, PHQ demonstrates good reliability, validity, and appropriate factor structure in a Greek-speaking college population. Psychometric research is needed on the Greek PHQ in primary care settings., (Copyright © 2012 Elsevier Inc. All rights reserved.)