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1,226 results on '"Mulcahey, Mary"'

103. Following Anterior Cruciate Ligament Reconstruction With Bone-Patellar Tendon-Bone Autograft, the Incidence of Anterior Knee Pain Ranges From 5.4% to 48.4% and the Incidence of Kneeling Pain Ranges From 4.0% to 75.6%: A Systematic Review of Level I Studies

Author

Peebles, Liam, Akamefula, Ramesses, Aman, Zachary, Verma, Arjun, Scillia, Anthony, Mulcahey, Mary, Kraeutler, Matthew, Peebles, Liam, Akamefula, Ramesses, Aman, Zachary, Verma, Arjun, Scillia, Anthony, Mulcahey, Mary, and Kraeutler, Matthew

Abstract

PURPOSE: To (1) perform a systematic review of level I randomized controlled trials (RCTs) detailing the incidence of anterior knee pain and kneeling pain following anterior cruciate ligament reconstruction (ACLR) with bone-patellar tendon-bone (BPTB) autograft and (2) investigate the effect of bone grafting the patellar harvest site on anterior knee and kneeling pain. METHODS: A systematic review of level I studies from 1980 to 2023 was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The primary outcome evaluated was the presence of donor site morbidity in the form of anterior knee pain or kneeling pain. A secondary subanalysis was performed to assess for differences in the incidence of postoperative pain between patient groups undergoing ACLR with BPTB receiving harvest site bone grafting and those in whom the defect was left untreated. RESULTS: Following full-text review, 15 studies reporting on a total of 696 patients met final inclusion criteria. Patients were followed for an average of 4.78 years (range, 2.0-15.3), and the mean age ranged from 21.7 to 38 years old. The incidence of anterior knee pain, calculated from 354 patients across 10 studies, ranged from 5.4% to 48.4%. The incidence of postoperative pain with kneeling was determined to range from 4.0% to 75.6% in 490 patients from 9 studies. Patients treated with bone grafting of the BPTB harvest site had no significant difference in incidence of any knee pain compared with those who were not grafted, with incidences of 43.3% and 40.2%, respectively. CONCLUSIONS: Based on the current level I RCT data, the incidences of anterior knee pain and kneeling pain following ACLR with BPTB autograft range from 5.4% to 48.4% and 4.0% to 75.6%, respectively. LEVEL OF EVIDENCE: Level I, systematic review of RCTs.

Published
2024

105. What's Important: #OrthoTwitter as an Online Community for Orthopaedic Surgeons.

Author

Bellaire, Christopher P., Ottesen, Taylor D., Gu, Alex, Mulcahey, Mary K., and Levine, William N.

Subjects
SURGEONS, VIRTUAL communities
Abstract

The authors reflect on the impact of the #OrthoTwitter community on the social media platform X, formerly known as Twitter, on the careers of orthopaedic surgery professionals and its use during the COVID-19 pandemic. Topics discussed include the characterization of the extent of the use of the #OrthoTwitter community using Twitter's Academic Research Developer Application Programming Interface, and the opportunity offered by the growth of the community's engagement for orthopaedic surgeons.

Published
2024
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106. Analysis of Graft Types Augmented With an Internal Brace for ACL Reconstruction: A Systematic Review.

Author

Maginnis, Connor, Root, Cooper, Schiavo, Julie H., Ierulli, Victoria K., Vopat, Bryan, and Mulcahey, Mary K.

Subjects
MEDICAL information storage & retrieval systems, QUADRICEPS tendon, BIOMECHANICS, ANTERIOR cruciate ligament injuries, ANTERIOR cruciate ligament surgery, AUTOGRAFTS, HAMSTRING muscle, ORTHOPEDIC apparatus, SYSTEMATIC reviews, MEDLINE, SURGICAL complications, MEDICAL databases, KNEE injuries
Abstract

Background: New techniques are being developed to decrease the failure rate of anterior cruciate ligament (ACL) grafts and prevent revision surgery. One such technique involves high-strength suture tape (ST), also referred to as internal bracing. Recent literature has highlighted the use of ST for ACL reconstruction, but no study has compared ST augmentation between graft types. Purpose: To compare the use of ST augmentation for ACL reconstruction based on the type of graft used (ie, bone–patellar tendon–bone [BPTB], quadriceps, hamstring). Study Design: Systematic review; Level of evidence, 5. Methods: An online search of multiple databases was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was completed April 2022 to identify studies related to ST augmentation of ACL grafts. Results: Of 926 studies identified, 10 met inclusion criteria. Five studies (50%) used hamstring tendon (HT), 3 (30%) used quadriceps tendon (QT), 1 (10%) used BPTB, and 1 (10%) used both HT and QT grafts. HT autografts augmented with ST had decreased dynamic and peak elongation (15%-56%), increased load to failure, and increased initial and final dynamic stiffness compared with controls. There was no significant difference in postoperative physical examination findings (range of motion, Lachman, pivot shift), except that ST-augmented grafts had significantly less laxity after surgery compared with HT alone (0.8 vs 1.9 mm; P <.05). QT allografts with ST augmentation showed increased graft strength. Human QT autograft studies showed higher Knee injury and Osteoarthritis Outcome Score scores compared with controls. BPTB allografts with ST augmentation had decreased cyclic displacement by 31% (P =.015) and increased load (758 ± 128 N; P <.001) and stiffness (156 ± 23 N/mm; P =.003) compared with nonaugmented groups. The complication rate was low or showed no increase in the ST augmentation groups compared with control groups. Conclusion: HT, QT, and BPTB grafts augmented with ST demonstrate an effective method for ACL reconstruction. All graft types with ST augmentation showed no evidence of clinical disadvantage, with some studies indicating significant biomechanical or clinical advantages compared with conventional ACL reconstruction. [ABSTRACT FROM AUTHOR]

Published
2024
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112. Following Anterior Cruciate Ligament Reconstruction with Bone-Patellar Tendon-Bone Autograft, the Incidence of Anterior Knee Pain Ranges From 18.0% to 48.0% and the Incidence of Kneeling Pain Ranges From 10.0% to 62.0%: A Systematic Review of Level I Studies

Author

Peebles, Liam A., primary, Akamefula, Ramesses A., additional, Aman, Zachary S., additional, Verma, Arjun, additional, Scillia, Anthony J., additional, Mulcahey, Mary K., additional, and Kraeutler, Matthew J., additional

Published
2024
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123. Biomimetic Proteoglycans Strengthen the Pericellular Matrix of Normal and Osteoarthritic Human Cartilage

Author

Kahle, Elizabeth R., Fallahi, Hooman, Bergstrom, Annika R., Li, Anita, Trouillot, Colette E., Mulcahey, Mary K., Lu, X. Lucas, Han, Lin, and Marcolongo, Michele S.

Abstract

In osteoarthritis (OA), degradation of cartilage pericellular matrix (PCM), the proteoglycan-rich immediate cell microniche, is a leading event of disease initiation. This study demonstrated that biomimetic proteoglycans (BPGs) can diffuse into human cartilage from both normal and osteoarthritic donors and are preferentially localized within the PCM. Applying immunofluorescence (IF)-guided AFM nanomechanical mapping, we show that this localization of BPGs increases the PCM micromodulus of both normal and OA specimens. These results illustrate the capability of BPGs to integrate with degenerative tissues and support the translational potential of BPGs for treating human OA and other diseases associated with proteoglycan degradation.

Published
2024
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