Search

Your search keyword '"Montecucco, Carlomaurizio"' showing total 1,168 results
Start Over Author "Montecucco, Carlomaurizio"
1,168 results on '"Montecucco, Carlomaurizio"'

102. Health-related quality of life in patients with mixed connective tissue disease: a comparison with matched systemic sclerosis patients

Author

Abouyahya, Imane, primary, Liem, Sophie I.E., additional, Amoura, Zahir, additional, Cabral da Fonseca, João E., additional, Chaigne, Benjamin, additional, Cutolo, Maurizio, additional, Doria, Andrea, additional, Fischer-Betz, Rebecca, additional, Guimaraes, Vera, additional, Huizinga, Thomas W.J., additional, van Laar, Jacob M., additional, Martin, Thierry, additional, Matucci-Cerinic, Marco, additional, Montecucco, Carlomaurizio, additional, Schneider, Matthias, additional, Smith, Vanessa, additional, and de Vries-Bouwstra, Jeska K., additional

Published
2021
Full Text
View/download PDF

103. Impact of immunosuppressive treatment on the immunogenicity of mRNA COVID-19 vaccine in vulnerable patients with giant cell arteritis

Author

Delvino, Paolo, primary, Bartoletti, Alice, additional, Cassaniti, Irene, additional, Bergami, Federica, additional, Lilleri, Daniele, additional, Baldanti, Fausto, additional, Bozzalla Cassione, Emanuele, additional, Biglia, Alessandro, additional, Montecucco, Carlomaurizio, additional, and Monti, Sara, additional

Published
2021
Full Text
View/download PDF

105. Impact of smoking habit on adult-onset Still’s disease prognosis, findings from a multicentre observational study

Author

Ruscitti, Piero, primary, Di Cola, Ilenia, additional, Berardicurti, Onorina, additional, Conforti, Alessandro, additional, Iacono, Daniela, additional, Pantano, Ilenia, additional, Rozza, Gelsomina, additional, Rossi, Silvia, additional, De Stefano, Ludovico, additional, Balduzzi, Silvia, additional, Vitale, Antonio, additional, Caso, Francesco, additional, Costa, Luisa, additional, Prete, Marcella, additional, Navarini, Luca, additional, Atzeni, Fabiola, additional, Guggino, Giuliana, additional, Perosa, Federico, additional, Cantarini, Luca, additional, Frediani, Bruno, additional, Montecucco, Carlomaurizio, additional, Ciccia, Francesco, additional, Giacomelli, Roberto, additional, and Cipriani, Paola, additional

Published
2021
Full Text
View/download PDF

106. Plasma derived-exosome microRNAs in Idiopathic Pulmonary Fibrosis of Anti-synthetase syndrome Disease patients

Author

Bozzini, Sara, primary, Zanframundo, Giovanni, additional, Codullo, Veronica, additional, Frangipane, Vanessa, additional, Pandolfi, Laura, additional, Lettieri, Sara, additional, Atienza-Mateo, Belèn, additional, Remuzgo Martinez, Sara, additional, Montecucco, Carlomaurizio, additional, Gonzalez-Gay, Miguel A., additional, Cavagna, Lorenzo, additional, and Meloni, Federica, additional

Published
2021
Full Text
View/download PDF

107. Cost‐Effectivenessof the Early Arthritis Clinic Organizational Model

Author

Zanetti, Anna, Sakellariou, Garifallia, Zambon, Antonella, Carrara, Greta, Argnani, Lisa, Mantovani, Lorenzo G., Cortesi, Paolo A., Bugatti, Serena, Montecucco, Carlomaurizio, and Scirè, Carlo A.

Abstract

Early diagnosis and tight control improve outcomes of rheumatoid arthritis (RA). However, whether establishing an early arthritis clinic (EAC) is sustainable for national health systems is not known. This analysis aimed to compare effectiveness and costs of an EAC compared to patients followed by the current standard of care. A retrospective study on administrative health databases of patients with a new diagnosis of RA was conducted: 430 patients followed in an EAC were enrolled, and 4 non‐EAC controls were randomly matched for each. During 2 years of follow‐up, the mean health care costs (outpatient, inpatient, pharmaceutical, and global) and 3 effectiveness measures (number and length of hospitalization and quality of care) of the EAC and non‐EAC were estimated. The incremental cost‐effectiveness ratio was calculated as well as the cost‐effectiveness acceptability curve. The cohorts included patients with a mean age of 55.4 years, and 1,506 patients (70%) were female. The mean pharmaceutical (2,602 versus 1,945 euros) and outpatient (2,447 versus 1,778 euros) costs were higher in the EAC cohort. Conversely, a higher rate of non‐EAC patients had a low adherence to quality‐of‐care indicators. The expected number of hospitalizations and the length of stay were statistically significantly higher in the non‐EAC versus EAC. Despite an expected increase in outpatient costs (visits and diagnostic tests) and pharmaceutical costs, the reduction in terms of number and length of hospitalizations and the higher adherence to international quality‐of‐care guidelines support the effectiveness of the EAC model.

Published
2023
Full Text
View/download PDF

108. Validation of EULAR primary Sjögrenʼs syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)

Author

Seror, Raphaèle, Theander, Elke, Brun, Johan G, Ramos-Casals, Manel, Valim, Valeria, Dörner, Thomas, Bootsma, Hendrika, Tzioufas, Athanasios, Solans-Laqué, Roser, Mandl, Thomas, Gottenberg, Jacques-Eric, Hachulla, Eric, Sivils, Kathy L, Ng, Wan-Fai, Fauchais, Anne-Laure, Bombardieri, Stefano, Valesini, Guido, Bartoloni, Elena, Saraux, Alain, Tomsic, Matija, Sumida, Takayuki, Nishiyama, Susumu, Caporali, Roberto, Kruize, Aike A, Vollenweider, Cristina, Ravaud, Philippe, Vitali, Claudio, Mariette, Xavier, Bowman, Simon J, Gerli, Roberto, Kallenberg, Cees, Meiners, Petra, De Vita, Salvatore, Devauchelle, Valerie, Demoulins, Frederic, Montecucco, Carlomaurizio, Praprotnik, Sonja, and Scofield, Hal

Published
2015
Full Text
View/download PDF

113. Methotrexate in Italian patients wiTh Rheumatoid Arthritis (MITRA study): an observational study about the use of methotrexate in early RA patients and the adherence to the EULAR 2013 recommendations. A project of the Italian Society for Rheumatology

Author

Benaglio, Francesca, primary, Fornaro, Marco, additional, Montecucco, Carlomaurizio, additional, Raffeiner, Bernd, additional, Di Franco, Manuela, additional, Iannuccelli, Cristina, additional, Conigliaro, Paola, additional, Lomater, Claudia, additional, Govoni, Marcello, additional, Silvagni, Ettore, additional, Zanetti, Anna, additional, Parisi, Simone, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Iannone, Florenzo, additional, and Caporali, Roberto, additional

Published
2021
Full Text
View/download PDF

114. Adherence of Italian rheumatologists to the EULAR recommendations and outcomes in early rheumatoid arthritis patients after starting conventional DMARDs: Methotrexate in Italian patients wiTh Rheumatoid Arthritis (the MITRA study). A cohort study of the I

Author

Fornaro, Marco, primary, Benaglio, Francesca, additional, Montecucco, Carlomaurizio, additional, Raffeiner, Bernd, additional, Di Franco, Manuela, additional, Iannuccelli, Cristina, additional, Conigliaro, Paola, additional, Lomater, Claudia, additional, Govoni, Marcello, additional, Silvagni, Ettore, additional, Zanetti, Anna, additional, Parisi, Simone, additional, Carrara, Greta, additional, Scirè, Carlo Alberto, additional, Caporali, Roberto, additional, and Iannone, Florenzo, additional

Published
2021
Full Text
View/download PDF

115. Ultrasound halo sign as a potential monitoring tool for patients with giant cell arteritis: a prospective analysis

Author

Ponte, Cristina, primary, Monti, Sara, additional, Scirè, Carlo Alberto, additional, Delvino, Paolo, additional, Khmelinskii, Nikita, additional, Milanesi, Alessandra, additional, Teixeira, Vítor, additional, Brandolino, Fabio, additional, Saraiva, Fernando, additional, Montecucco, Carlomaurizio, additional, Fonseca, João Eurico, additional, Schmidt, Wolfgang A, additional, and Luqmani, Raashid Ahmed, additional

Published
2021
Full Text
View/download PDF

116. Retention rate of IL-1 inhibitors in Schnitzler's syndrome

Author

Crisafulli, Francesca, primary, Vitale, Antonio, additional, Airò, Paolo, additional, Grigis, Marco, additional, Gaggiano, Carla, additional, Dagna, Lorenzo, additional, Cavalli, Giulio, additional, Cimaz, Rolando, additional, Viapiana, Ombretta, additional, Iannone, Florenzo, additional, Lopalco, Giuseppe, additional, Bortolotti, Roberto, additional, Abdel Jaber, Masen, additional, Montecucco, Carlomaurizio, additional, Monti, Sara, additional, Balduzzi, Silvia, additional, Emmi, Giacomo, additional, Mattioli, Irene, additional, Franceschini, Franco, additional, Cantarini, Luca, additional, and Frassi, Micol, additional

Published
2021
Full Text
View/download PDF

118. Methotrexate and glucocorticoids, but not anticytokine therapy, impair the immunogenicity of a single dose of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic inflammatory arthritis

Author

Bugatti, Serena, primary, De Stefano, Ludovico, additional, Balduzzi, Silvia, additional, Greco, Maria Immacolata, additional, Luvaro, Terenzj, additional, Cassaniti, Irene, additional, Bogliolo, Laura, additional, Mazzucchelli, Iolanda, additional, D’Onofrio, Bernardo, additional, di Lernia, Michele, additional, Mauric, Eleonora, additional, Lilleri, Daniele, additional, Baldanti, Fausto, additional, Manzo, Antonio, additional, and Montecucco, Carlomaurizio, additional

Published
2021
Full Text
View/download PDF

122. The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET.

Author

UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Talarico, Rosaria, Aguilera, Silvia, Alexander, Tobias, Amoura, Zahir, Antunes, Ana M, Arnaud, Laurent, Avcin, Tadej, Beretta, Lorenzo, Bombardieri, Stefano, Burmester, Gerd R, Cannizzo, Sara, Cavagna, Lorenzo, Chaigne, Benjamin, Cornet, Alain, Costedoat-Chalumeau, Nathalie, Doria, Andrea, Ferraris, Alessandro, Fischer-Betz, Rebecca, Fonseca, João E, Frank, Charissa, Gaglioti, Andrea, Galetti, Ilaria, Grunert, Jürgen, Guimarães, Vera, Hachulla, Eric, Houssiau, Frédéric, Iaccarino, Luca, Krieg, Thomas, Limper, Marteen, Malfait, Fransiska, Mariette, Xavier, Marinello, Diana, Martin, Thierry, Matthews, Lisa, Matucci-Cerinic, Marco, Meyer, Alain, Montecucco, Carlomaurizio, Mouthon, Luc, Müller-Ladner, Ulf, Rednic, Simona, Romão, Vasco C, Schneider, Matthias, Smith, Vanessa, Sulli, Alberto, Tamirou, Farah, Taruscio, Domenica, Taulaigo, Anna V, Terol, Enrique, Tincani, Angela, Ticciati, Simone, Turchetti, Giuseppe, van Hagen, P Martin, van Laar, Jacob M, Vieira, Ana, de Vries-Bouwstra, Jeska K, Cutolo, Maurizio, Mosca, Marta, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Talarico, Rosaria, Aguilera, Silvia, Alexander, Tobias, Amoura, Zahir, Antunes, Ana M, Arnaud, Laurent, Avcin, Tadej, Beretta, Lorenzo, Bombardieri, Stefano, Burmester, Gerd R, Cannizzo, Sara, Cavagna, Lorenzo, Chaigne, Benjamin, Cornet, Alain, Costedoat-Chalumeau, Nathalie, Doria, Andrea, Ferraris, Alessandro, Fischer-Betz, Rebecca, Fonseca, João E, Frank, Charissa, Gaglioti, Andrea, Galetti, Ilaria, Grunert, Jürgen, Guimarães, Vera, Hachulla, Eric, Houssiau, Frédéric, Iaccarino, Luca, Krieg, Thomas, Limper, Marteen, Malfait, Fransiska, Mariette, Xavier, Marinello, Diana, Martin, Thierry, Matthews, Lisa, Matucci-Cerinic, Marco, Meyer, Alain, Montecucco, Carlomaurizio, Mouthon, Luc, Müller-Ladner, Ulf, Rednic, Simona, Romão, Vasco C, Schneider, Matthias, Smith, Vanessa, Sulli, Alberto, Tamirou, Farah, Taruscio, Domenica, Taulaigo, Anna V, Terol, Enrique, Tincani, Angela, Ticciati, Simone, Turchetti, Giuseppe, van Hagen, P Martin, van Laar, Jacob M, Vieira, Ana, de Vries-Bouwstra, Jeska K, Cutolo, Maurizio, and Mosca, Marta

Abstract

During the COVID-19 pandemic, the need to provide high-level care for a large number of patients with COVID-19 has affected resourcing for, and limited the routine care of, all other conditions. The impact of this health emergency is particularly relevant in the rare connective tissue diseases (rCTDs) communities, as discussed in this Perspective article by the multi-stakeholder European Reference Network on Rare and Complex Connective Tissue and Musculoskeletal Diseases (ERN ReCONNET). The clinical, organizational and health economic challenges faced by health-care providers, institutions, patients and their families during the SARS-CoV-2 outbreak have demonstrated the importance of ensuring continuity of care in the management of rCTDs, including adequate diagnostics and monitoring protocols, and highlighted the need for a structured emergency strategy. The vulnerability of patients with rCTDs needs to be taken into account when planning future health policies, in preparation for not only the post-COVID era, but also any possible new health emergencies.

Published
2021

123. Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial.

Author

UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Humby, Frances, Durez, Patrick, Buch, Maya H, Lewis, Myles J, Rizvi, Hasan, Rivellese, Felice, Nerviani, Alessandra, Giorli, Giovanni, Mahto, Arti, Montecucco, Carlomaurizio, Lauwerys, Bernard, Ng, Nora, Ho, Pauline, Bombardieri, Michele, Romão, Vasco C, Verschueren, Patrick, Kelly, Stephen, Sainaghi, Pier Paolo, Gendi, Nagui, Dasgupta, Bhaskar, Cauli, Alberto, Reynolds, Piero, Cañete, Juan D, Moots, Robert, Taylor, Peter C, Edwards, Christopher J, Isaacs, John, Sasieni, Peter, Choy, Ernest, Pitzalis, Costantino, R4RA collaborative group, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Humby, Frances, Durez, Patrick, Buch, Maya H, Lewis, Myles J, Rizvi, Hasan, Rivellese, Felice, Nerviani, Alessandra, Giorli, Giovanni, Mahto, Arti, Montecucco, Carlomaurizio, Lauwerys, Bernard, Ng, Nora, Ho, Pauline, Bombardieri, Michele, Romão, Vasco C, Verschueren, Patrick, Kelly, Stephen, Sainaghi, Pier Paolo, Gendi, Nagui, Dasgupta, Bhaskar, Cauli, Alberto, Reynolds, Piero, Cañete, Juan D, Moots, Robert, Taylor, Peter C, Edwards, Christopher J, Isaacs, John, Sasieni, Peter, Choy, Ernest, Pitzalis, Costantino, and R4RA collaborative group

Abstract

Although targeted biological treatments have transformed the outlook for patients with rheumatoid arthritis, 40% of patients show poor clinical response, which is mechanistically still unexplained. Because more than 50% of patients with rheumatoid arthritis have low or absent CD20 B cells-the target for rituximab-in the main disease tissue (joint synovium), we hypothesised that, in these patients, the IL-6 receptor inhibitor tocilizumab would be more effective. The aim of this trial was to compare the effect of tocilizumab with rituximab in patients with rheumatoid arthritis who had an inadequate response to anti-tumour necrosis factor (TNF) stratified for synovial B-cell status. This study was a 48-week, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial (rituximab vs tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis; R4RA) done in 19 centres across five European countries (the UK, Belgium, Italy, Portugal, and Spain). Patients aged 18 years or older who fulfilled the 2010 American College of Rheumatology and European League Against Rheumatism classification criteria for rheumatoid arthritis and were eligible for treatment with rituximab therapy according to UK National Institute for Health and Care Excellence guidelines were eligible for inclusion in the trial. To inform balanced stratification, following a baseline synovial biopsy, patients were classified histologically as B-cell poor or rich. Patients were then randomly assigned (1:1) centrally in block sizes of six and four to receive two 1000 mg rituximab infusions at an interval of 2 weeks (rituximab group) or 8 mg/kg tocilizumab infusions at 4-week intervals (tocilizumab group). To enhance the accuracy of the stratification of B-cell poor and B-cell rich patients, baseline synovial biopsies from all participants were subjected to RNA sequencing and reclassified by B-cell molecular signature. The study was powered to test the superiority of tocilizumab o

Published
2021

124. Serum IgG2 antibody multi-composition in systemic lupus erythematosus and in lupus nephritis (Part 2): prospective study

Author

Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, Ghiggeri, Gian Marco, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, and Ghiggeri, Gian Marco

Abstract

Objectives: Circulating anti-ENO1 and anti-H2A IgG2 have been identified as specific signatures of LN in a cross-over approach. We sought to show whether the same antibodies identify selected population of patients with LN with potentially different clinical outcomes. Methods: Here we report the prospective analysis over 36 months of circulating IgG2 levels in patients with newly diagnosed LN (n=91) and SLE (n=31) and in other patients with SLE recruited within 2 years from diagnosis (n=99). Anti-podocyte (ENO1), anti-nucleosome (DNA, histone 2 A, histone 3) and anti-circulating proteins (C1q, AnnexinA1-ANXA1) IgG2 antibodies were determined by home-made techniques. Results: LN patients were the main focus of the study. Anti-ENO1, anti-H2A and anti-ANXA1 IgG2 decreased in parallel to proteinuria and normalized within 12 months in the majority of patients while anti-dsDNA IgG2 remained high over the 36 months. Anti-ENO1 and anti-H2A had the highest association with proteinuria (Heat Map) and identified the highest number of patients with high proteinuria (68% and 71% respectively) and/or with reduced estimated glomerula filtration rate (eGFR) (58% for both antibodies) compared with 23% and 17% of anti-dsDNA (agreement analysis). Anti-ENO1 positive LN patients had higher proteinuria than negative patients at T0 and presented the maximal decrement within 12 months. Conclusions: Anti-ENO1, anti-H2A and anti-ANXA1 antibodies were associated with high proteinuria in LN patients and Anti-ENO1 also presented the maximal reduction within 12 months that paralleled the decrease of proteinuria. Anti-dsDNA were not associated with renal outcome parameters. New IgG2 antibody signatures should be utilized as tracers of personalized therapies in LN. Trial registration: The Zeus study was registered at https://clinicaltrials.gov (study number: NCT02403115).

Published
2021

125. Second wave antibodies in autoimmune renal diseases: The case of lupus nephritis

Author

Angeletti, A, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Ravelli, A, Ghiggeri, G, Angeletti, Andrea, Bruschi, Maurizio, Moroni, Gabriela, Sinico, Renato, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Ravelli, Angelo, Ghiggeri, Gian Marco, Angeletti, A, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, D'Alessandro, M, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Volpi, S, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Verrina, E, Ravelli, A, Ghiggeri, G, Angeletti, Andrea, Bruschi, Maurizio, Moroni, Gabriela, Sinico, Renato, Franceschini, Franco, Fredi, Micaela, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello, Manfredi, Angelo, Ramirez, Giuseppe, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, d'Alessandro, Matteo, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Volpi, Stefano, Mosca, Marta, Tincani, Angela, Candiano, Giovanni, Prunotto, Marco, Verrina, Enrico, Ravelli, Angelo, and Ghiggeri, Gian Marco

Abstract

Clinical Trial registry name and registration number: Zeus study, NCT02403115

Published
2021

126. Risk of acute arterial and venous thromboembolic events in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss syndrome)

Author

Bettiol, A, Sinico, R, Schiavon, F, Monti, S, Bozzolo, E, Franceschini, F, Govoni, M, Lunardi, C, Guida, G, Lopalco, G, Paolazzi, G, Vacca, A, Gregorini, G, Leccese, P, Piga, M, Conti, F, Fraticelli, P, Quartuccio, L, Alberici, F, Salvarani, C, Bettio, S, Negrini, S, Selmi, C, Sciascia, S, Moroni, G, Colla, L, Manno, C, Urban, M, Vannacci, A, Pozzi, M, Fabbrini, P, Polti, S, Felicetti, M, Marchi, M, Padoan, R, Delvino, P, Caporali, R, Montecucco, C, Dagna, L, Cariddi, A, Toniati, P, Tamanini, S, Furini, F, Bortoluzzi, A, Tinazzi, E, Delfino, L, Badiu, I, Rolla, G, Venerito, V, Iannone, F, Berti, A, Bortolotti, R, Racanelli, V, Jeannin, G, Padula, A, Cauli, A, Priori, R, Gabrielli, A, Bond, M, Tedesco, M, Pazzola, G, Tomietto, P, Pellecchio, M, Marvisi, C, Maritati, F, Palmisano, A, Dejaco, C, Willeit, J, Kiechl, S, Olivotto, I, Willeit, P, Prisco, D, Vaglio, A, Emmi, G, Bettiol, Alessandra, Sinico, Renato Alberto, Schiavon, Franco, Monti, Sara, Bozzolo, Enrica Paola, Franceschini, Franco, Govoni, Marcello, Lunardi, Claudio, Guida, Giuseppe, Lopalco, Giuseppe, Paolazzi, Giuseppe, Vacca, Angelo, Gregorini, Gina, Leccese, Pietro, Piga, Matteo, Conti, Fabrizio, Fraticelli, Paolo, Quartuccio, Luca, Alberici, Federico, Salvarani, Carlo, Bettio, Silvano, Negrini, Simone, Selmi, Carlo, Sciascia, Savino, Moroni, Gabriella, Colla, Loredana, Manno, Carlo, Urban, Maria Letizia, Vannacci, Alfredo, Pozzi, Maria Rosa, Fabbrini, Paolo, Polti, Stefano, Felicetti, Mara, Marchi, Maria Rita, Padoan, Roberto, Delvino, Paolo, Caporali, Roberto, Montecucco, Carlomaurizio, Dagna, Lorenzo, Cariddi, Adriana, Toniati, Paola, Tamanini, Silvia, Furini, Federica, Bortoluzzi, Alessandra, Tinazzi, Elisa, Delfino, Lorenzo, Badiu, Iuliana, Rolla, Giovanni, Venerito, Vincenzo, Iannone, Florenzo, Berti, Alvise, Bortolotti, Roberto, Racanelli, Vito, Jeannin, Guido, Padula, Angela, Cauli, Alberto, Priori, Roberta, Gabrielli, Armando, Bond, Milena, Tedesco, Martina, Pazzola, Giulia, Tomietto, Paola, Pellecchio, Marco, Marvisi, Chiara, Maritati, Federica, Palmisano, Alessandra, Dejaco, Christian, Willeit, Johann, Kiechl, Stefan, Olivotto, Iacopo, Willeit, Peter, Prisco, Domenico, Vaglio, Augusto, Emmi, Giacomo, Bettiol, A, Sinico, R, Schiavon, F, Monti, S, Bozzolo, E, Franceschini, F, Govoni, M, Lunardi, C, Guida, G, Lopalco, G, Paolazzi, G, Vacca, A, Gregorini, G, Leccese, P, Piga, M, Conti, F, Fraticelli, P, Quartuccio, L, Alberici, F, Salvarani, C, Bettio, S, Negrini, S, Selmi, C, Sciascia, S, Moroni, G, Colla, L, Manno, C, Urban, M, Vannacci, A, Pozzi, M, Fabbrini, P, Polti, S, Felicetti, M, Marchi, M, Padoan, R, Delvino, P, Caporali, R, Montecucco, C, Dagna, L, Cariddi, A, Toniati, P, Tamanini, S, Furini, F, Bortoluzzi, A, Tinazzi, E, Delfino, L, Badiu, I, Rolla, G, Venerito, V, Iannone, F, Berti, A, Bortolotti, R, Racanelli, V, Jeannin, G, Padula, A, Cauli, A, Priori, R, Gabrielli, A, Bond, M, Tedesco, M, Pazzola, G, Tomietto, P, Pellecchio, M, Marvisi, C, Maritati, F, Palmisano, A, Dejaco, C, Willeit, J, Kiechl, S, Olivotto, I, Willeit, P, Prisco, D, Vaglio, A, Emmi, G, Bettiol, Alessandra, Sinico, Renato Alberto, Schiavon, Franco, Monti, Sara, Bozzolo, Enrica Paola, Franceschini, Franco, Govoni, Marcello, Lunardi, Claudio, Guida, Giuseppe, Lopalco, Giuseppe, Paolazzi, Giuseppe, Vacca, Angelo, Gregorini, Gina, Leccese, Pietro, Piga, Matteo, Conti, Fabrizio, Fraticelli, Paolo, Quartuccio, Luca, Alberici, Federico, Salvarani, Carlo, Bettio, Silvano, Negrini, Simone, Selmi, Carlo, Sciascia, Savino, Moroni, Gabriella, Colla, Loredana, Manno, Carlo, Urban, Maria Letizia, Vannacci, Alfredo, Pozzi, Maria Rosa, Fabbrini, Paolo, Polti, Stefano, Felicetti, Mara, Marchi, Maria Rita, Padoan, Roberto, Delvino, Paolo, Caporali, Roberto, Montecucco, Carlomaurizio, Dagna, Lorenzo, Cariddi, Adriana, Toniati, Paola, Tamanini, Silvia, Furini, Federica, Bortoluzzi, Alessandra, Tinazzi, Elisa, Delfino, Lorenzo, Badiu, Iuliana, Rolla, Giovanni, Venerito, Vincenzo, Iannone, Florenzo, Berti, Alvise, Bortolotti, Roberto, Racanelli, Vito, Jeannin, Guido, Padula, Angela, Cauli, Alberto, Priori, Roberta, Gabrielli, Armando, Bond, Milena, Tedesco, Martina, Pazzola, Giulia, Tomietto, Paola, Pellecchio, Marco, Marvisi, Chiara, Maritati, Federica, Palmisano, Alessandra, Dejaco, Christian, Willeit, Johann, Kiechl, Stefan, Olivotto, Iacopo, Willeit, Peter, Prisco, Domenico, Vaglio, Augusto, and Emmi, Giacomo

Published
2021

127. Significance of PR3-ANCA positivity in eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Author

Papo, M, Sinico, R, Teixeira, V, Venhoff, N, Urban, M, Iudici, M, Mahrhold, J, Locatelli, F, Cassone, G, Schiavon, F, Seeliger, B, Neumann, T, Kroegel, C, Groh, M, Marvisi, C, Samson, M, Barba, T, Jayne, D, Troilo, A, Thiel, J, Hellmich, B, Monti, S, Montecucco, C, Salvarani, C, Kahn, J, Bonnotte, B, Durel, C, Puéchal, X, Mouthon, L, Guillevin, L, Emmi, G, Vaglio, A, Terrier, B, Papo, Matthias, Sinico, Renato A, Teixeira, Vítor, Venhoff, Nils, Urban, Maria-Letizia, Iudici, Michele, Mahrhold, Juliane, Locatelli, Francesco, Cassone, Giulia, Schiavon, Franco, Seeliger, Benjamin, Neumann, Thomas, Kroegel, Claus, Groh, Matthieu, Marvisi, Chiara, Samson, Maxime, Barba, Thomas, Jayne, David, Troilo, Arianna, Thiel, Jens, Hellmich, Bernhard, Monti, Sara, Montecucco, Carlomaurizio, Salvarani, Carlo, Kahn, Jean-Emmanuel, Bonnotte, Bernard, Durel, Cécile-Audrey, Puéchal, Xavier, Mouthon, Luc, Guillevin, Loïc, Emmi, Giacomo, Vaglio, Augusto, Terrier, Benjamin, Papo, M, Sinico, R, Teixeira, V, Venhoff, N, Urban, M, Iudici, M, Mahrhold, J, Locatelli, F, Cassone, G, Schiavon, F, Seeliger, B, Neumann, T, Kroegel, C, Groh, M, Marvisi, C, Samson, M, Barba, T, Jayne, D, Troilo, A, Thiel, J, Hellmich, B, Monti, S, Montecucco, C, Salvarani, C, Kahn, J, Bonnotte, B, Durel, C, Puéchal, X, Mouthon, L, Guillevin, L, Emmi, G, Vaglio, A, Terrier, B, Papo, Matthias, Sinico, Renato A, Teixeira, Vítor, Venhoff, Nils, Urban, Maria-Letizia, Iudici, Michele, Mahrhold, Juliane, Locatelli, Francesco, Cassone, Giulia, Schiavon, Franco, Seeliger, Benjamin, Neumann, Thomas, Kroegel, Claus, Groh, Matthieu, Marvisi, Chiara, Samson, Maxime, Barba, Thomas, Jayne, David, Troilo, Arianna, Thiel, Jens, Hellmich, Bernhard, Monti, Sara, Montecucco, Carlomaurizio, Salvarani, Carlo, Kahn, Jean-Emmanuel, Bonnotte, Bernard, Durel, Cécile-Audrey, Puéchal, Xavier, Mouthon, Luc, Guillevin, Loïc, Emmi, Giacomo, Vaglio, Augusto, and Terrier, Benjamin

Abstract

OBJECTIVES: Only a third of patients with eosinophilic granulomatosis with polyangiitis (EGPA) are ANCA-positive, mainly directed against MPO. ANCA directed against PR3 are rarely found in EGPA. We aimed to examine the significance of PR3-ANCA in EGPA. METHODS: We set up a retrospective European multicentre cohort including 845 patients. Baseline characteristics and outcomes were analysed and compared according to ANCA status. RESULTS: ANCA status was available for 734 patients: 508 (69.2%) ANCA-negative, 210 (28.6%) MPO-ANCA and 16 (2.2%) PR3-ANCA. At baseline, PR3-ANCA patients, compared with those with MPO-ANCA and ANCA-negative, less frequently had active asthma (69% vs 91% and 93%, P = 0.003, respectively) and peripheral neuropathy (31% vs 71% and 47%, P < 0.0001), more frequently had cutaneous manifestations (63% vs 38% and 34%, P = 0.03) and pulmonary nodules (25% vs 10% and 8%, P = 0.046), and lower median eosinophil count (1450 vs 5400 and 3224/mm3, P < 0.0001). Vasculitis relapse-free survival was shorter for PR3-ANCA (hazard ratio 6.05, P = 0.005) and MPO-ANCA patients (hazard ratio 1.88, P = 0.0002) compared with ANCA-negative patients. CONCLUSION: PR3-ANCA EGPA patients differ from those with MPO-ANCA and negative ANCA, and share clinical features with granulomatosis with polyangiitis. This suggests that PR3-ANCA EGPA could be a particular form of PR3-ANCA-associated vasculitis.

Published
2021

128. Serum IgG2 antibody multicomposition in systemic lupus erythematosus and lupus nephritis (Part 1): cross-sectional analysis

Author

Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Volpi, S, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela&nbsp, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello&nbsp, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Mosca, Marta, Tincani, Angela&nbsp, Candiano, Giovanni, Prunotto, Marco, Volpi, Stefano, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, Ghiggeri, Gian Marco, Bruschi, M, Moroni, G, Sinico, R, Franceschini, F, Fredi, M, Vaglio, A, Cavagna, L, Petretto, A, Pratesi, F, Migliorini, P, Locatelli, F, Pazzola, G, Pesce, G, Bagnasco, M, Manfredi, A, Ramirez, G, Esposito, P, Murdaca, G, Negrini, S, Cipriani, L, Trezzi, B, Emmi, G, Cavazzana, I, Binda, V, Fenaroli, P, Pisani, I, Garibotto, G, Montecucco, C, Santoro, D, Scolari, F, Mosca, M, Tincani, A, Candiano, G, Prunotto, M, Volpi, S, Verrina, E, Angeletti, A, Ravelli, A, Ghiggeri, G, Bruschi, Maurizio, Moroni, Gabriella, Sinico, Renato Alberto, Franceschini, Franco, Fredi, Micaela&nbsp, Vaglio, Augusto, Cavagna, Lorenzo, Petretto, Andrea, Pratesi, Federico, Migliorini, Paola, Locatelli, Francesco, Pazzola, Giulia, Pesce, Giampaola, Bagnasco, Marcello&nbsp, Manfredi, Angelo, Ramirez, Giuseppe A, Esposito, Pasquale, Murdaca, Giuseppe, Negrini, Simone, Cipriani, Leda, Trezzi, Barbara, Emmi, Giacomo, Cavazzana, Ilaria, Binda, Valentina, Fenaroli, Paride, Pisani, Isabella, Garibotto, Giacomo, Montecucco, Carlomaurizio, Santoro, Domenico, Scolari, Francesco, Mosca, Marta, Tincani, Angela&nbsp, Candiano, Giovanni, Prunotto, Marco, Volpi, Stefano, Verrina, Enrico, Angeletti, Andrea, Ravelli, Angelo, and Ghiggeri, Gian Marco

Abstract

Objectives: Serum anti-dsDNA and anti-nucleosome IgGs have been proposed as signatures for SLE and LN in limited numbers of patients. We sought to show higher sensitivity and specificity of the same antibodies with the IgG2 isotype and included IgG2 antibodies vs specific intracellular antigens in the analysis. Methods: A total of 1052 SLE patients with (n = 479) and without (n = 573) LN, recruited at different times from the beginning of symptoms, were included in the study. Patients with primary APS (PAPS, n = 24), RA (RA, n = 24) and UCTD (UCTD, n = 96) were analysed for comparison. Anti-nucleosome (dsDNA, Histone2A, Histone3), anti-intracellular antigens (ENO1), anti-annexin A1 and anti-C1q IgG2 were determined by non-commercial techniques. Results: The presence in the serum of the IgG2 panel was highly discriminatory for SLE/LN vs healthy subjects. Serum levels of anti-dsDNA and anti-C1q IgG2 were more sensitive than those of IgGs (Farr radioimmunoassay/commercial assays) in identifying SLE patients at low-medium increments. Of more importance, serum positivity for anti-ENO1 and anti-H2A IgG2 discriminated between LN and SLE (ROC T0-12 months), and high levels at T0-1 month were detected in 63% and 67%, respectively, of LN, vs 3% and 3%, respectively, of SLE patients; serum positivity for each of these was correlated with high SLEDAI values. Minor differences existed between LN/SLE and the other rheumatologic conditions. Conclusion: Nephritogenic IgG2 antibodies represent a specific signature of SLE/LN, with a few overlaps with other rheumatologic conditions. High levels of anti-ENO1 and anti-H2A IgG2 correlated with SLE activity indexes and were discriminatory between SLE patients limited to the renal complication and other SLE patients. Trial registration: The Zeus study was registered at https://clinicaltrials.gov, NCT02403115.

Published
2021

129. The impact of COVID-19 on rare and complex connective tissue diseases: the experience of ERN ReCONNET

Author

Infection & Immunity, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, Talarico, Rosaria, Aguilera, Silvia, Alexander, Tobias, Amoura, Zahir, Antunes, Ana M, Arnaud, Laurent, Avcin, Tadej, Beretta, Lorenzo, Bombardieri, Stefano, Burmester, Gerd R, Cannizzo, Sara, Cavagna, Lorenzo, Chaigne, Benjamin, Cornet, Alain, Costedoat-Chalumeau, Nathalie, Doria, Andrea, Ferraris, Alessandro, Fischer-Betz, Rebecca, Fonseca, João E, Frank, Charissa, Gaglioti, Andrea, Galetti, Ilaria, Grunert, Jürgen, Guimarães, Vera, Hachulla, Eric, Houssiau, Frederic, Iaccarino, Luca, Krieg, Thomas, Limper, Marteen, Malfait, Fransiska, Mariette, Xavier, Marinello, Diana, Martin, Thierry, Matthews, Lisa, Matucci-Cerinic, Marco, Meyer, Alain, Montecucco, Carlomaurizio, Mouthon, Luc, Müller-Ladner, Ulf, Rednic, Simona, Romão, Vasco C, Schneider, Matthias, Smith, Vanessa, Sulli, Alberto, Tamirou, Farah, Taruscio, Domenica, Taulaigo, Anna V, Terol, Enrique, Tincani, Angela, van Laar, Jacob M, ERN ReCONNET investigators, Infection & Immunity, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, Talarico, Rosaria, Aguilera, Silvia, Alexander, Tobias, Amoura, Zahir, Antunes, Ana M, Arnaud, Laurent, Avcin, Tadej, Beretta, Lorenzo, Bombardieri, Stefano, Burmester, Gerd R, Cannizzo, Sara, Cavagna, Lorenzo, Chaigne, Benjamin, Cornet, Alain, Costedoat-Chalumeau, Nathalie, Doria, Andrea, Ferraris, Alessandro, Fischer-Betz, Rebecca, Fonseca, João E, Frank, Charissa, Gaglioti, Andrea, Galetti, Ilaria, Grunert, Jürgen, Guimarães, Vera, Hachulla, Eric, Houssiau, Frederic, Iaccarino, Luca, Krieg, Thomas, Limper, Marteen, Malfait, Fransiska, Mariette, Xavier, Marinello, Diana, Martin, Thierry, Matthews, Lisa, Matucci-Cerinic, Marco, Meyer, Alain, Montecucco, Carlomaurizio, Mouthon, Luc, Müller-Ladner, Ulf, Rednic, Simona, Romão, Vasco C, Schneider, Matthias, Smith, Vanessa, Sulli, Alberto, Tamirou, Farah, Taruscio, Domenica, Taulaigo, Anna V, Terol, Enrique, Tincani, Angela, van Laar, Jacob M, and ERN ReCONNET investigators

Published
2021

134. Multinational evidence-based recommendations for the diagnosis and management of gout: integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative

Author

Sivera, Francisca, Andrés, Mariano, Carmona, Loreto, Kydd, Alison S R, Moi, John, Seth, Rakhi, Sriranganathan, Melonie, van Durme, Caroline, van Echteld, Irene, Vinik, Ophir, Wechalekar, Mihir D, Aletaha, Daniel, Bombardier, Claire, Buchbinder, Rachelle, Edwards, Christopher J, Landewé, Robert B, Bijlsma, Johannes W, Branco, Jaime C, Burgos-Vargas, Rubén, Catrina, Anca I, Elewaut, Dirk, Ferrari, Antonio J L, Kiely, Patrick, Leeb, Burkhard F, Montecucco, Carlomaurizio, Müller-Ladner, Ulf, Østergaard, Mikkel, Zochling, Jane, Falzon, Louise, and van der Heijde, Désirée M

Published
2014
Full Text
View/download PDF

135. Nailfold capillaroscopy characteristics of antisynthetase syndrome and possible clinical associations : Results of a multicenter international study

Author

Sebastiani, Marco, Triantafyllias, Konstantinos, Manfredi, Andreina, González-Gay, Miguel Angel, Palmou-Fontana, Natalia, Cassone, Giulia, Drott, Ulrich, Delbrück, Christiane, Rojas-Serrano, Jorge, Bertolazzi, Chiara, Nuño, Laura, Giannini, Margherita, Iannone, Florenzo, Vicente, Esther F., Castañeda, Santos, Selva-O'Callaghan, Albert, Araguas, Ernesto Trallero, Emmi, Giacomo, Iuliano, Annamaria, Bauhammer, Jutta, Miehle, Nikolaus, Parisi, Simone, Cavagna, Lorenzo, Codullo, Veronica, Montecucco, Carlomaurizio, Lopez-Longo, Francisco Javier, Martínez-Barrio, Julia, Nieto-González, Juan Carlos, Vichi, Silvia, Confalonieri, Marco, Tomietto, Paola, Bergner, Raoul, Sulli, Alberto, Bonella, Francesco, Furini, Federica, Scirè, Carlo Alberto, Bortoluzzi, Alessandra, Specker, Christof, Barsotti, Simone, Neri, Rossella, Mosca, Marta, Caproni, Marzia, Weinmann-Menke, Julia, Schwarting, Andreas, Smith, Vanessa, Cutolo, Maurizio, Selva-O’Callaghan, Albert, Sebastiani, M, Triantafyllias, K, Manfredi, A, Gonzalez-Gay, M, Palmou-Fontana, N, Cassone, G, Drott, U, Delbruck, C, Rojas-Serrano, J, Bertolazzi, C, Nuno, L, Giannini, M, Iannone, F, Vicente, E, Castaneda, S, Selva-O'Callaghan, A, Araguas, E, Emmi, G, Iuliano, A, Bauhammer, J, Miehle, N, Parisi, S, Cavagna, L, Codullo, V, Montecucco, C, Lopez-Longo, F, Martinez-Barrio, J, Nieto-Gonzalez, J, Vichi, S, Confalonieri, M, Tomietto, P, Bergner, R, Sulli, A, Bonella, F, Furini, F, Scire, C, Bortoluzzi, A, Specker, C, Barsotti, S, Neri, R, Mosca, M, Caproni, M, Weinmann-Menke, J, Schwarting, A, Smith, V, Cutolo, M, Sebastiani, Marco, Triantafyllias, Konstantino, Manfredi, Andreina, Angel González-Gay, Miguel, Palmou-Fontana, Natalia, Cassone, Giulia, Drott, Ulrich, Delbrück, Christiane, Rojas-Serrano, Jorge, Bertolazzi, Chiara, Nuño, Laura, Giannini, Margherita, Iannone, Florenzo, Vicente, Esther F., Castañeda, Santo, Selva-O’Callaghan, Albert, Trallero Araguas, Ernesto, Emmi, Giacomo, Iuliano, Annamaria, Bauhammer, Jutta, Miehle, Nikolau, Parisi, Simone, Cavagna, Lorenzo, Codullo, Veronica, Montecucco, Carlomaurizio, Javier Lopez-Longo, Francisco, Martínez-Barrio, Julia, Carlos Nieto-González, Juan, Vichi, Silvia, Confalonieri, Marco, Tomietto, Paola, Bergner, Raoul, Sulli, Alberto, Bonella, Francesco, Furini, Federica, Alberto Scirè, Carlo, Bortoluzzi, Alessandra, Specker, Christof, Barsotti, Simone, Neri, Rossella, Mosca, Marta, Caproni, Marzia, Weinmann-Menke, Julia, Schwarting, Andrea, Smith, Vanessa, and Cutolo, Maurizio

Subjects
Male, Medizin, Antisynthetase syndrome, ANTISYNTHETASE ANTIBODIES, Disease, Serology, Microscopic Angioscopy, 0302 clinical medicine, Interquartile range, Capillaroscopy, Anti-synthetase syndrome, Immunology and Allergy, 030212 general & internal medicine, Raynaud phenomenon, Prospective cohort study, Myositis, Nailfold Capillaroscopy, Middle Aged, ANTISYNTHETASE SYNDROME, NAILFOLD VIDEOCAPILLAROSCOPY, RAYNAUD PHENOMENON, SYSTEMIC SCLEROSIS PATTERN, Antibodies, Antinuclear, Female, Adult, medicine.medical_specialty, Nailfold capillaroscopy, anti-synthetase syndrome, myositis, Immunology, Systemic sclerosis pattern, NO, Amino Acyl-tRNA Synthetases, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, Humans, Aged, Retrospective Studies, 030203 arthritis & rheumatology, Antisynthetase antibodie, business.industry, Nailfold videocapillaroscopy, Raynaud Disease, Antisynthetase antibodies, Antisynthetase syndrome, Nailfold videocapillaroscopy, Raynaud phenomenon, Systemic sclerosis pattern, medicine.disease, Capillaries, Nails, business, Follow-Up Studies
Abstract

Objective.To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease.Methods.We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non–anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern. Finally, we correlated NVC features with clinical and serological findings of patients with AS. Concomitantly, a historical cohort of 75 patients with antinuclear antibody–negative primary Raynaud phenomenon (RP) and longterm followup was used as a control group (female/male ratio 4.13/1, mean age 53.9 ± 17.6 yrs) for NVC measures.Results.NVC abnormalities were observed in 62.1% of AS patients compared with 29.3% of primary RP group (p < 0.001). An SSc-like pattern was detected in 67 patients (35.3%) and it was associated with anti-Jo1 antibodies (p = 0.002) and also with a longer disease duration (p = 0.004). Interestingly, there was no significant correlation between the presence of SSc-like pattern and RP, and only 47% of patients with SSc-like pattern had RP.Conclusion.NVC abnormalities are commonly observed in AS, independently from the occurrence of RP. The presence of an SSc-like pattern could allow identification of a more defined AS subtype, and prospective studies could confirm the association with clinical and serological features of AS.

Published
2019

140. Risk of acute arterial and venous thromboembolic events in eosinophilic granulomatosis with polyangiitis (Churg–Strauss syndrome)

Author

Bettiol, Alessandra, primary, Sinico, Renato Alberto, additional, Schiavon, Franco, additional, Monti, Sara, additional, Bozzolo, Enrica Paola, additional, Franceschini, Franco, additional, Govoni, Marcello, additional, Lunardi, Claudio, additional, Guida, Giuseppe, additional, Lopalco, Giuseppe, additional, Paolazzi, Giuseppe, additional, Vacca, Angelo, additional, Gregorini, Gina, additional, Leccese, Pietro, additional, Piga, Matteo, additional, Conti, Fabrizio, additional, Fraticelli, Paolo, additional, Quartuccio, Luca, additional, Alberici, Federico, additional, Salvarani, Carlo, additional, Bettio, Silvano, additional, Negrini, Simone, additional, Selmi, Carlo, additional, Sciascia, Savino, additional, Moroni, Gabriella, additional, Colla, Loredana, additional, Manno, Carlo, additional, Urban, Maria Letizia, additional, Vannacci, Alfredo, additional, Pozzi, Maria Rosa, additional, Fabbrini, Paolo, additional, Polti, Stefano, additional, Felicetti, Mara, additional, Marchi, Maria Rita, additional, Padoan, Roberto, additional, Delvino, Paolo, additional, Caporali, Roberto, additional, Montecucco, Carlomaurizio, additional, Dagna, Lorenzo, additional, Cariddi, Adriana, additional, Toniati, Paola, additional, Tamanini, Silvia, additional, Furini, Federica, additional, Bortoluzzi, Alessandra, additional, Tinazzi, Elisa, additional, Delfino, Lorenzo, additional, Badiu, Iuliana, additional, Rolla, Giovanni, additional, Venerito, Vincenzo, additional, Iannone, Florenzo, additional, Berti, Alvise, additional, Bortolotti, Roberto, additional, Racanelli, Vito, additional, Jeannin, Guido, additional, Padula, Angela, additional, Cauli, Alberto, additional, Priori, Roberta, additional, Gabrielli, Armando, additional, Bond, Milena, additional, Tedesco, Martina, additional, Pazzola, Giulia, additional, Tomietto, Paola, additional, Pellecchio, Marco, additional, Marvisi, Chiara, additional, Maritati, Federica, additional, Palmisano, Alessandra, additional, Dejaco, Christian, additional, Willeit, Johann, additional, Kiechl, Stefan, additional, Olivotto, Iacopo, additional, Willeit, Peter, additional, Prisco, Domenico, additional, Vaglio, Augusto, additional, and Emmi, Giacomo, additional

Published
2021
Full Text
View/download PDF

141. Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital

Author

Cereda, Emanuele, primary, Bogliolo, Laura, additional, Klersy, Catherine, additional, Lobascio, Federica, additional, Masi, Sara, additional, Crotti, Silvia, additional, De Stefano, Ludovico, additional, Bruno, Raffaele, additional, Corsico, Angelo Guido, additional, Di Sabatino, Antonio, additional, Perlini, Stefano, additional, Montecucco, Carlomaurizio, additional, Caccialanza, Riccardo, additional, Belliato, Mirko, additional, Ludovisi, Serena, additional, Mariani, Francesca, additional, Ferrari, Alessandra, additional, Musella, Valeria, additional, Muggia, Chiara, additional, Croce, Gabriele, additional, Barteselli, Chiara, additional, Mambella, Jacopo, additional, and Di Terlizzi, Francesco, additional

Published
2021
Full Text
View/download PDF

143. Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals

Author

Andreoli, Laura, primary, Nalli, Cecilia, additional, Lazzaroni, Maria Grazia, additional, Carini, Chiara, additional, Dall’Ara, Francesca, additional, Reggia, Rossella, additional, Rodrigues, Marília, additional, Benigno, Carolina, additional, Baldissera, Elena, additional, Bartoloni, Elena, additional, Basta, Fabio, additional, Bellisai, Francesca, additional, Bortoluzzi, Alessandra, additional, Campochiaro, Corrado, additional, Cantatore, Francesco Paolo, additional, Caporali, Roberto, additional, Ceribelli, Angela, additional, Chighizola, Cecilia B., additional, Conigliaro, Paola, additional, Corrado, Addolorata, additional, Cutolo, Maurizio, additional, D’Angelo, Salvatore, additional, De Stefani, Elena, additional, Doria, Andrea, additional, Favaro, Maria, additional, Fischetti, Colomba, additional, Foti, Rosario, additional, Gabrielli, Armando, additional, Generali, Elena, additional, Gerli, Roberto, additional, Gerosa, Maria, additional, Larosa, Maddalena, additional, Maier, Armin, additional, Malavolta, Nazzarena, additional, Meroni, Marianna, additional, Meroni, Pier Luigi, additional, Montecucco, Carlomaurizio, additional, Mosca, Marta, additional, Padovan, Melissa, additional, Paolazzi, Giuseppe, additional, Pazzola, Giulia, additional, Peccatori, Susanna, additional, Perricone, Roberto, additional, Pettiti, Giorgio, additional, Picerno, Valentina, additional, Prevete, Immacolata, additional, Ramoni, Véronique, additional, Romeo, Nicoletta, additional, Ruffatti, Amelia, additional, Salvarani, Carlo, additional, Sebastiani, Gian Domenico, additional, Selmi, Carlo, additional, Serale, Francesca, additional, Sinigaglia, Luigi, additional, Tani, Chiara, additional, Trevisani, Marica, additional, Vadacca, Marta, additional, Valentini, Eleonora, additional, Valesini, Guido, additional, Visalli, Elisa, additional, Vivaldelli, Ester, additional, Zuliani, Lucia, additional, and Tincani, Angela, additional

Published
2021
Full Text
View/download PDF

146. Evolving the comprehensive management of rheumatoid arthritis: identification of unmet needs and development of practical and educational tools.

Author

UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Burmester, Gerd-Rüdiger, Álvaro-Gracia, José María, Betteridge, Neil, Calvo Alén, Jaime, Combe, Bernard, Durez, Patrick, Fautrel, Bruno, Ferreira, Ricardo J O, Gabay, Cem, Iagnocco, Annamaria, Montecucco, Carlomaurizio, Østergaard, Mikkel, Ramiro, Sofia, Rubbert-Roth, Andrea, Stamm, Tanja, Szekanecz, Zoltán, Taylor, Peter C, van de Laar, Mart, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie, Burmester, Gerd-Rüdiger, Álvaro-Gracia, José María, Betteridge, Neil, Calvo Alén, Jaime, Combe, Bernard, Durez, Patrick, Fautrel, Bruno, Ferreira, Ricardo J O, Gabay, Cem, Iagnocco, Annamaria, Montecucco, Carlomaurizio, Østergaard, Mikkel, Ramiro, Sofia, Rubbert-Roth, Andrea, Stamm, Tanja, Szekanecz, Zoltán, Taylor, Peter C, and van de Laar, Mart

Abstract

OBJECTIVES: Despite availability of efficacious treatments, unmet needs still exist, preventing optimal and comprehensive management of rheumatoid arthritis (RA). Evolving the management of RA (eRA) is a European-wide educational initiative aiming to support improved patient care through practical and educational tools addressing specific unmet needs. METHODS: A multidisciplinary Steering Committee (17 members, 12 countries) identified unmet needs within the management of RA and prioritised those with the greatest impact on patient outcomes. Practical educational tools addressing priority needs were then developed for dissemination and implementation by the rheumatology community across Europe. RESULTS: Five areas of priority need were identified: increasing early recognition of RA and treatment initiation; treating RA to target; optimal, holistic approach to selection of treatment strategy, including shared decision-making; improving identification and management of comorbidities; and non-pharmacological patient management. A suite of 14 eRA tools included educational slides, best-practice guidance, self assessment questionnaires, clinical checklists, a multidisciplinary team training exercise, an interactive patient infographic, and case scenarios. By April 2020, rheumatology professionals in 17 countries had been actively engaged in the eRA programme; in 11 countries, eRA tools were selected by national leaders in rheumatology and translated for local dissemination. A web platform, with country-specific pages, was developed to support access to the translated tools (https://www.evolvingthemanagementofra.com/). CONCLUSIONS: The eRA programme supports comprehensive management of RA across Europe through development and dissemination of practical educational tools. The eRA tools address priority needs and are available free of charge to the rheumatology community.

Published
2020

147. Evolving the comprehensive management of rheumatoid arthritis:identification of unmet needs and development of practical and educational tools

Author

Burmester, Gerd Rüdiger, Álvaro-Gracia, José María, Betteridge, Neil, Calvo Alén, Jaime, Combe, Bernard, Durez, Patrick, Fautrel, Bruno, Ferreira, Ricardo J.O., Gabay, Cem, Iagnocco, Annamaria, Montecucco, Carlomaurizio, Østergaard, Mikkel, Ramiro, Sofia, Rubbert-Roth, Andrea, Stamm, Tanja, Szekanecz, Zoltán, Taylor, Peter C., van de Laar, Mart, Burmester, Gerd Rüdiger, Álvaro-Gracia, José María, Betteridge, Neil, Calvo Alén, Jaime, Combe, Bernard, Durez, Patrick, Fautrel, Bruno, Ferreira, Ricardo J.O., Gabay, Cem, Iagnocco, Annamaria, Montecucco, Carlomaurizio, Østergaard, Mikkel, Ramiro, Sofia, Rubbert-Roth, Andrea, Stamm, Tanja, Szekanecz, Zoltán, Taylor, Peter C., and van de Laar, Mart

Abstract

OBJECTIVES: Despite availability of efficacious treatments, unmet needs still exist, preventing optimal and comprehensive management of rheumatoid arthritis (RA). Evolving the management of RA (eRA) is a European-wide educational initiative aiming to support improved patient care through practical and educational tools addressing specific unmet needs. METHODS: A multidisciplinary Steering Committee (17 members, 12 countries) identified unmet needs within the management of RA and prioritised those with the greatest impact on patient outcomes. Practical educational tools addressing priority needs were then developed for dissemination and implementation by the rheumatology community across Europe. RESULTS: Five areas of priority need were identified: increasing early recognition of RA and treatment initiation; treating RA to target; optimal, holistic approach to selection of treatment strategy, including shared decision-making; improving identification and management of comorbidities; and non-pharmacological patient management. A suite of 14 eRA tools included educational slides, best-practice guidance, self‑assessment questionnaires, clinical checklists, a multidisciplinary team training exercise, an interactive patient infographic, and case scenarios. By April 2020, rheumatology professionals in 17 countries had been actively engaged in the eRA programme; in 11 countries, eRA tools were selected by national leaders in rheumatology and translated for local dissemination. A web platform, with country-specific pages, was developed to support access to the translated tools (https://www.evolvingthemanagementofra.com/). CONCLUSIONS: The eRA programme supports comprehensive management of RA across Europe through development and dissemination of practical educational tools. The eRA tools address priority needs and are available free of charge to the rheumatology community.

Published
2020

149. Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial

Author

Humby, Frances, primary, Durez, Patrick, additional, Buch, Maya H, additional, Lewis, Myles J, additional, Rizvi, Hasan, additional, Rivellese, Felice, additional, Nerviani, Alessandra, additional, Giorli, Giovanni, additional, Mahto, Arti, additional, Montecucco, Carlomaurizio, additional, Lauwerys, Bernard, additional, Ng, Nora, additional, Ho, Pauline, additional, Bombardieri, Michele, additional, Romão, Vasco C, additional, Verschueren, Patrick, additional, Kelly, Stephen, additional, Sainaghi, Pier Paolo, additional, Gendi, Nagui, additional, Dasgupta, Bhaskar, additional, Cauli, Alberto, additional, Reynolds, Piero, additional, Cañete, Juan D, additional, Moots, Robert, additional, Taylor, Peter C, additional, Edwards, Christopher J, additional, Isaacs, John, additional, Sasieni, Peter, additional, Choy, Ernest, additional, Pitzalis, Costantino, additional, Thompson, Charlotte, additional, Bugatti, Serena, additional, Bellan, Mattia, additional, Congia, Mattia, additional, Holroyd, Christopher, additional, Pratt, Arthur, additional, Cabral da Fonseca, João Eurico, additional, White, Laura, additional, Warren, Louise, additional, Peel, Joanna, additional, Hands, Rebecca, additional, Fossati-Jimack, Liliane, additional, Hadfield, Gaye, additional, Thorborn, Georgina, additional, Ramirez, Julio, additional, and Celis, Raquel, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results